NFATC3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Several transcript variants encoding distinct isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.69875426
2regulation of gamma-delta T cell differentiation (GO:0045586)5.31668519
3positive regulation of granulocyte differentiation (GO:0030854)5.11249072
4regulation of gamma-delta T cell activation (GO:0046643)4.79028823
5negative T cell selection (GO:0043383)4.73349708
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.54718001
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.54718001
8histone H3-K36 demethylation (GO:0070544)4.27764425
9positive thymic T cell selection (GO:0045059)4.26006886
10positive T cell selection (GO:0043368)4.24851556
11negative thymic T cell selection (GO:0045060)4.18758127
12antigen processing and presentation of endogenous antigen (GO:0019883)4.15133338
13T cell selection (GO:0045058)3.98310005
14thymic T cell selection (GO:0045061)3.82761914
15regulation of granulocyte differentiation (GO:0030852)3.80711133
16mast cell degranulation (GO:0043303)3.80690575
17mast cell activation involved in immune response (GO:0002279)3.80690575
18nuclear pore complex assembly (GO:0051292)3.76602387
19V(D)J recombination (GO:0033151)3.71684833
20mitotic sister chromatid cohesion (GO:0007064)3.71539287
21negative regulation of T cell mediated immunity (GO:0002710)3.60287055
22positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.58944935
23negative regulation of T cell apoptotic process (GO:0070233)3.57372694
24positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.57065939
25mast cell activation (GO:0045576)3.55730649
26negative regulation of cell killing (GO:0031342)3.48689365
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.48689365
28positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.41805235
29response to interleukin-15 (GO:0070672)3.40513873
30CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)3.40107567
31T-helper cell differentiation (GO:0042093)3.40107567
32nuclear pore organization (GO:0006999)3.36462206
33interferon-gamma production (GO:0032609)3.35667984
34negative regulation of thymocyte apoptotic process (GO:0070244)3.35450540
35positive regulation of histone deacetylation (GO:0031065)3.31991280
36negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.31203270
37regulation of natural killer cell mediated immunity (GO:0002715)3.26082678
38regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.26082678
39negative regulation of lymphocyte mediated immunity (GO:0002707)3.25118503
40positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.24424682
41positive regulation of natural killer cell mediated immunity (GO:0002717)3.23745263
42tolerance induction (GO:0002507)3.21552784
43antigen processing and presentation via MHC class Ib (GO:0002475)3.18157804
44positive regulation of T cell mediated cytotoxicity (GO:0001916)3.17975179
45DNA unwinding involved in DNA replication (GO:0006268)3.07915825
46regulation of T cell mediated cytotoxicity (GO:0001914)3.03743787
47regulation of RNA export from nucleus (GO:0046831)3.03568813
48positive regulation of alpha-beta T cell proliferation (GO:0046641)3.03280318
49regulation of leukocyte mediated cytotoxicity (GO:0001910)3.01398552
50regulation of B cell differentiation (GO:0045577)3.00969092
51T cell costimulation (GO:0031295)3.00521992
52positive regulation of B cell differentiation (GO:0045579)2.99873712
53T cell receptor signaling pathway (GO:0050852)2.97044216
54T cell differentiation involved in immune response (GO:0002292)2.96424072
55alpha-beta T cell differentiation involved in immune response (GO:0002293)2.96424072
56alpha-beta T cell activation involved in immune response (GO:0002287)2.96424072
57regulation of interleukin-12 biosynthetic process (GO:0045075)2.95612278
58regulation of T cell tolerance induction (GO:0002664)2.94550656
59lymphocyte costimulation (GO:0031294)2.93606697
60leukocyte degranulation (GO:0043299)2.92769877
61positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.92056367
62cellular extravasation (GO:0045123)2.89276556
63positive regulation of cell killing (GO:0031343)2.87958272
64negative regulation of histone methylation (GO:0031061)2.84641289
65cytoplasmic mRNA processing body assembly (GO:0033962)2.83472936
66pore complex assembly (GO:0046931)2.82688261
67activated T cell proliferation (GO:0050798)2.82285173
68regulation of histone H3-K9 methylation (GO:0051570)2.80382048
69negative regulation of T-helper cell differentiation (GO:0045623)2.79822511
70negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.79822511
71antigen receptor-mediated signaling pathway (GO:0050851)2.79404356
72regulation of regulatory T cell differentiation (GO:0045589)2.78386391
73regulation of necroptotic process (GO:0060544)2.78379915
74CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.78182425
75B cell receptor signaling pathway (GO:0050853)2.77927360
76positive regulation by host of viral transcription (GO:0043923)2.76905740
77cellular response to interleukin-15 (GO:0071350)2.76822027
78monoubiquitinated protein deubiquitination (GO:0035520)2.74030844
79regulation of B cell receptor signaling pathway (GO:0050855)2.73876811
80leukocyte aggregation (GO:0070486)2.73767016
81antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.73749818
82pre-miRNA processing (GO:0031054)2.72667283
83T cell homeostasis (GO:0043029)2.72616639
84negative regulation of leukocyte mediated immunity (GO:0002704)2.72033724
85CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.71462900
86mRNA cleavage (GO:0006379)2.70316337
87regulation of cell killing (GO:0031341)2.68822403
88positive regulation of interleukin-2 production (GO:0032743)2.67374765
89mitotic chromosome condensation (GO:0007076)2.66284121
90natural killer cell differentiation (GO:0001779)2.65957428
91definitive hemopoiesis (GO:0060216)2.65897026
92regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.65663156
93negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.65200667
94lymph node development (GO:0048535)2.64893647
95T cell differentiation (GO:0030217)2.64598166
96positive regulation of T cell chemotaxis (GO:0010820)2.64569344
97regulation of T cell chemotaxis (GO:0010819)2.64569344
98positive regulation of alpha-beta T cell activation (GO:0046635)2.63833341
99hepatocyte apoptotic process (GO:0097284)2.62612382
100TOR signaling (GO:0031929)2.62228950
101JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.61755369
102regulation of alpha-beta T cell activation (GO:0046634)2.58235638
103negative regulation of erythrocyte differentiation (GO:0045647)2.57842730
104positive regulation of tolerance induction (GO:0002645)2.57523742
105T cell proliferation (GO:0042098)2.57493390
106regulation of histone H3-K27 methylation (GO:0061085)2.55383110
107positive regulation of protein deacetylation (GO:0090312)2.55341112
108T cell migration (GO:0072678)2.52794378
109mucosal-associated lymphoid tissue development (GO:0048537)2.50952762
110Peyers patch development (GO:0048541)2.50952762
111mitotic nuclear envelope disassembly (GO:0007077)2.50599996
112RNA stabilization (GO:0043489)2.50597236
113mRNA stabilization (GO:0048255)2.50597236
114DNA duplex unwinding (GO:0032508)2.49765730
115heterochromatin organization (GO:0070828)2.48974043
116regulation of thymocyte apoptotic process (GO:0070243)2.48368629
117dosage compensation (GO:0007549)2.48229844
118regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.46547003
119protein localization to kinetochore (GO:0034501)2.46196917
120lymphocyte homeostasis (GO:0002260)2.46049856
121histone mRNA catabolic process (GO:0071044)2.45983458
122DNA geometric change (GO:0032392)2.45874415
123glucocorticoid receptor signaling pathway (GO:0042921)2.44420918
124alpha-beta T cell activation (GO:0046631)2.44128204
125regulation of nucleobase-containing compound transport (GO:0032239)2.41850043
126positive regulation of isotype switching (GO:0045830)2.40584111
127regulation of interleukin-2 biosynthetic process (GO:0045076)2.40168710
128alternative mRNA splicing, via spliceosome (GO:0000380)2.40155378
129cellular hyperosmotic response (GO:0071474)2.39533452
130somatic cell DNA recombination (GO:0016444)2.36426471
131somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.36426471
132alpha-beta T cell differentiation (GO:0046632)2.36391901
133negative regulation of phagocytosis (GO:0050765)2.36334616
134regulation of T cell receptor signaling pathway (GO:0050856)2.31814412
135regulation of alpha-beta T cell proliferation (GO:0046640)2.31356051
136nuclear envelope disassembly (GO:0051081)2.31077212
137membrane disassembly (GO:0030397)2.31077212
138NLS-bearing protein import into nucleus (GO:0006607)2.30878213
139regulation of DNA endoreduplication (GO:0032875)2.30766461
140negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.30730260
141response to UV-C (GO:0010225)2.30234575
142protein localization to chromosome, centromeric region (GO:0071459)2.28737362
143negative regulation of RNA splicing (GO:0033119)2.28719720
144regulation of translational fidelity (GO:0006450)2.28419890
145chromatin assembly (GO:0031497)2.27904788
146regulation of response to interferon-gamma (GO:0060330)2.27641769
147Arp2/3 complex-mediated actin nucleation (GO:0034314)2.27583531
148regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.26095453
149T cell differentiation in thymus (GO:0033077)2.25998124
150germ cell migration (GO:0008354)2.24847121

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.14798365
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.53954006
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.07116420
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.92941479
5* MYC_22102868_ChIP-Seq_BL_Human3.70318623
6* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.44449459
7* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.25293597
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.95475393
9CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.90696485
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.70489587
11* VDR_21846776_ChIP-Seq_THP-1_Human2.43443388
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.41471110
13* MYB_26560356_Chip-Seq_TH2_Human2.31940414
14* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.30859934
15MAF_26560356_Chip-Seq_TH1_Human2.26084765
16STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.20594484
17RUNX_20019798_ChIP-Seq_JUKART_Human2.15965827
18TCF7_22412390_ChIP-Seq_EML_Mouse2.15930655
19* UTX_26944678_Chip-Seq_JUKART_Human2.12187432
20MYB_26560356_Chip-Seq_TH1_Human2.10614073
21MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.09629222
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.04497845
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.02590908
24KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.98767391
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96744302
26VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.92600997
27ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.86104760
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.86054899
29SCL_19346495_ChIP-Seq_HPC-7_Human1.83312154
30VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.80471545
31GATA3_26560356_Chip-Seq_TH2_Human1.79532376
32STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.79071308
33EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.75785390
34KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.73645892
35MYB_21317192_ChIP-Seq_ERMYB_Mouse1.69969655
36CIITA_25753668_ChIP-Seq_RAJI_Human1.66980139
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63953266
38* KDM2B_26808549_Chip-Seq_DND41_Human1.63240393
39* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.62242234
40VDR_24763502_ChIP-Seq_THP-1_Human1.59876591
41NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.59863042
42IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.58077286
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55003807
44* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54774481
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.52377446
46* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.48368830
47EGR1_23403033_ChIP-Seq_LIVER_Mouse1.48021044
48RUNX1_22412390_ChIP-Seq_EML_Mouse1.46911243
49MAF_26560356_Chip-Seq_TH2_Human1.44885132
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.44150165
51SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.42671232
52ELK3_25401928_ChIP-Seq_HUVEC_Human1.39993401
53TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37667525
54SPI1_23547873_ChIP-Seq_NB4_Human1.35691064
55IRF8_27001747_Chip-Seq_BMDM_Mouse1.33991562
56* GATA3_27048872_Chip-Seq_THYMUS_Human1.33234271
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.33012749
58TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30578188
59AR_21909140_ChIP-Seq_LNCAP_Human1.28984818
60GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28411062
61GATA2_19941826_ChIP-Seq_K562_Human1.27944604
62MYC_18555785_ChIP-Seq_MESCs_Mouse1.26144846
63GATA1_19941826_ChIP-Seq_K562_Human1.24946526
64* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.24091408
65RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.23694535
66VDR_24787735_ChIP-Seq_THP-1_Human1.21217737
67AR_21572438_ChIP-Seq_LNCaP_Human1.21208447
68* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.20826878
69CLOCK_20551151_ChIP-Seq_293T_Human1.20330484
70ESR1_20079471_ChIP-ChIP_T-47D_Human1.19684040
71TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19427394
72* NCOR1_26117541_ChIP-Seq_K562_Human1.15507251
73TP63_17297297_ChIP-ChIP_HaCaT_Human1.14954896
74LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.12428296
75ER_23166858_ChIP-Seq_MCF-7_Human1.12289053
76IRF8_21731497_ChIP-ChIP_J774_Mouse1.11808621
77MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10573631
78* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10570795
79RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10351354
80GATA1_22025678_ChIP-Seq_K562_Human1.10001393
81* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09956472
82MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08555156
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.08142128
84KDM5A_27292631_Chip-Seq_BREAST_Human1.06038073
85ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05595169
86KDM2B_26808549_Chip-Seq_JURKAT_Human1.04606214
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04579919
88TP63_19390658_ChIP-ChIP_HaCaT_Human1.04439444
89LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04361343
90SPI1_23127762_ChIP-Seq_K562_Human1.03982342
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.00827679
92KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00164352
93PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.99761497
94NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.97836126
95TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.97398609
96PU_27001747_Chip-Seq_BMDM_Mouse0.96805710
97PPARA_22158963_ChIP-Seq_LIVER_Mouse0.96663460
98ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.95809085
99STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95728373
100GATA1_22383799_ChIP-Seq_G1ME_Mouse0.95391940
101NELFA_20434984_ChIP-Seq_ESCs_Mouse0.94511363
102CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.94493739
103* FOXO3_23340844_ChIP-Seq_DLD1_Human0.93749803
104CHD1_26751641_Chip-Seq_LNCaP_Human0.93660216
105GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.91648911
106FOXP3_21729870_ChIP-Seq_TREG_Human0.91099480
107* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.90899065
108* GATA3_26560356_Chip-Seq_TH1_Human0.90783965
109ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89773971
110FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.89370415
111GATA6_25053715_ChIP-Seq_YYC3_Human0.88795555
112PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88286514
113XRN2_22483619_ChIP-Seq_HELA_Human0.88181621
114RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.87473311
115PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86234371
116IRF1_19129219_ChIP-ChIP_H3396_Human0.85953983
117* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85659417
118SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85020637
119ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.84736619
120Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.84718002
121CTCF_21964334_ChIP-Seq_BJAB-B_Human0.84463037
122RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.84155798
123HOXB4_20404135_ChIP-ChIP_EML_Mouse0.83744112
124CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.83536267
125TFEB_21752829_ChIP-Seq_HELA_Human0.83467709
126VDR_23849224_ChIP-Seq_CD4+_Human0.83465690
127* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.82878238
128HIF1A_21447827_ChIP-Seq_MCF-7_Human0.82509352
129FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.81711977
130STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.81439058
131* MYC_19030024_ChIP-ChIP_MESCs_Mouse0.81310347
132P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81159306
133FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80142458
134ATF3_27146783_Chip-Seq_COLON_Human0.79385548
135PKCTHETA_26484144_Chip-Seq_BREAST_Human0.79179879
136SMRT_27268052_Chip-Seq_Bcells_Human0.78975675
137SMAD_19615063_ChIP-ChIP_OVARY_Human0.78819054
138TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.77910949
139GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77261217
140* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75115304
141CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.75061450
142TDRD3_21172665_ChIP-Seq_MCF-7_Human0.72962036

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004381_abnormal_hair_follicle3.14554630
2MP0005075_abnormal_melanosome_morpholog3.13277638
3MP0003763_abnormal_thymus_physiology3.13213053
4MP0002166_altered_tumor_susceptibility2.70887490
5MP0003300_gastrointestinal_ulcer2.61095360
6MP0010352_gastrointestinal_tract_polyps2.58878965
7MP0003724_increased_susceptibility_to2.48428064
8MP0002396_abnormal_hematopoietic_system2.45784537
9MP0000685_abnormal_immune_system2.42792843
10MP0001800_abnormal_humoral_immune2.27200653
11MP0005671_abnormal_response_to2.24284165
12MP0004808_abnormal_hematopoietic_stem2.07974866
13* MP0002398_abnormal_bone_marrow2.07442412
14* MP0000703_abnormal_thymus_morphology2.06996791
15MP0001835_abnormal_antigen_presentation2.05410041
16MP0002006_tumorigenesis2.03579250
17MP0005387_immune_system_phenotype2.01611267
18MP0001790_abnormal_immune_system2.01611267
19MP0005076_abnormal_cell_differentiation1.97363037
20MP0002138_abnormal_hepatobiliary_system1.89672098
21MP0003705_abnormal_hypodermis_morpholog1.85897791
22MP0009333_abnormal_splenocyte_physiolog1.82033290
23MP0004947_skin_inflammation1.81532699
24MP0010094_abnormal_chromosome_stability1.79869870
25* MP0002722_abnormal_immune_system1.76935527
26MP0002452_abnormal_antigen_presenting1.76849617
27MP0010155_abnormal_intestine_physiology1.75646366
28MP0001873_stomach_inflammation1.75143471
29* MP0002420_abnormal_adaptive_immunity1.73193426
30MP0009278_abnormal_bone_marrow1.73086641
31MP0000689_abnormal_spleen_morphology1.72637573
32* MP0001819_abnormal_immune_cell1.69789069
33* MP0000716_abnormal_immune_system1.69443555
34MP0008057_abnormal_DNA_replication1.69356066
35MP0002723_abnormal_immune_serum1.67960613
36MP0002405_respiratory_system_inflammati1.62205096
37MP0003172_abnormal_lysosome_physiology1.61685094
38MP0000569_abnormal_digit_pigmentation1.61080870
39MP0005000_abnormal_immune_tolerance1.59841524
40MP0003077_abnormal_cell_cycle1.56007508
41MP0010307_abnormal_tumor_latency1.55800752
42MP0003303_peritoneal_inflammation1.55499586
43MP0000015_abnormal_ear_pigmentation1.54869182
44MP0001545_abnormal_hematopoietic_system1.48648646
45MP0005397_hematopoietic_system_phenotyp1.48648646
46* MP0002429_abnormal_blood_cell1.47682093
47MP0003693_abnormal_embryo_hatching1.46334098
48MP0005451_abnormal_body_composition1.45636459
49MP0006054_spinal_hemorrhage1.43572262
50MP0004957_abnormal_blastocyst_morpholog1.37367745
51MP0003436_decreased_susceptibility_to1.36118061
52MP0003111_abnormal_nucleus_morphology1.35215451
53MP0000490_abnormal_crypts_of1.33010465
54MP0003566_abnormal_cell_adhesion1.32157773
55MP0002933_joint_inflammation1.31066260
56MP0003828_pulmonary_edema1.28240428
57MP0005025_abnormal_response_to1.28219303
58MP0005023_abnormal_wound_healing1.24797820
59MP0004185_abnormal_adipocyte_glucose1.23993251
60MP0010234_abnormal_vibrissa_follicle1.22888092
61MP0002019_abnormal_tumor_incidence1.21165867
62MP0000350_abnormal_cell_proliferation1.20387257
63MP0002148_abnormal_hypersensitivity_rea1.20212464
64MP0009785_altered_susceptibility_to1.18978191
65MP0005310_abnormal_salivary_gland1.17731819
66MP0001730_embryonic_growth_arrest1.16837034
67MP0001661_extended_life_span1.15042210
68MP0005464_abnormal_platelet_physiology1.12960762
69MP0001845_abnormal_inflammatory_respons1.12444928
70MP0000733_abnormal_muscle_development1.11575252
71MP0001849_ear_inflammation1.10917262
72MP0004197_abnormal_fetal_growth/weight/1.10323311
73MP0000858_altered_metastatic_potential1.08330957
74MP0000465_gastrointestinal_hemorrhage1.08178752
75MP0003806_abnormal_nucleotide_metabolis1.05903083
76MP0005408_hypopigmentation1.05379455
77MP0002877_abnormal_melanocyte_morpholog1.05101100
78MP0003866_abnormal_defecation1.04921900
79MP0001853_heart_inflammation1.04423173
80MP0006082_CNS_inflammation1.03679388
81* MP0002086_abnormal_extraembryonic_tissu1.03270494
82MP0002009_preneoplasia0.99951260
83MP0004264_abnormal_extraembryonic_tissu0.99365848
84MP0002419_abnormal_innate_immunity0.98713851
85MP0003448_altered_tumor_morphology0.97569517
86MP0009697_abnormal_copulation0.97325001
87MP0003656_abnormal_erythrocyte_physiolo0.96349145
88MP0003646_muscle_fatigue0.96254058
89* MP0002088_abnormal_embryonic_growth/wei0.95289492
90* MP0003984_embryonic_growth_retardation0.95167356
91MP0003453_abnormal_keratinocyte_physiol0.94974213
92MP0008007_abnormal_cellular_replicative0.94448447
93MP0002132_abnormal_respiratory_system0.92928019
94MP0001243_abnormal_dermal_layer0.92226651
95MP0008469_abnormal_protein_level0.91920622
96* MP0001672_abnormal_embryogenesis/_devel0.90390668
97* MP0005380_embryogenesis_phenotype0.90390668
98MP0004130_abnormal_muscle_cell0.88943661
99MP0003252_abnormal_bile_duct0.88453303
100MP0000371_diluted_coat_color0.88145255
101MP0003567_abnormal_fetal_cardiomyocyte0.86585552
102MP0000609_abnormal_liver_physiology0.86331343
103MP0001915_intracranial_hemorrhage0.85443037
104MP0003091_abnormal_cell_migration0.84464822
105MP0008995_early_reproductive_senescence0.83528468
106MP0003045_fibrosis0.83283361
107MP0008961_abnormal_basal_metabolism0.83280530
108* MP0001697_abnormal_embryo_size0.83225910
109MP0001919_abnormal_reproductive_system0.82703725
110MP0005410_abnormal_fertilization0.82267262
111MP0009115_abnormal_fat_cell0.82017144
112MP0008004_abnormal_stomach_pH0.81750220
113MP0001216_abnormal_epidermal_layer0.80260045
114MP0000383_abnormal_hair_follicle0.79758095
115MP0005389_reproductive_system_phenotype0.79254073
116MP0002693_abnormal_pancreas_physiology0.77994401
117* MP0002080_prenatal_lethality0.77094705
118* MP0000477_abnormal_intestine_morphology0.73864331
119MP0009840_abnormal_foam_cell0.73681889
120MP0000377_abnormal_hair_follicle0.72785452
121MP0010678_abnormal_skin_adnexa0.71982877
122MP0002060_abnormal_skin_morphology0.71693231
123MP0005058_abnormal_lysosome_morphology0.71376130
124MP0002084_abnormal_developmental_patter0.70793395
125MP0000313_abnormal_cell_death0.70720168
126MP0009053_abnormal_anal_canal0.69998758
127MP0001851_eye_inflammation0.69957422
128MP0001879_abnormal_lymphatic_vessel0.68937286
129MP0005360_urolithiasis0.68798134
130MP0005666_abnormal_adipose_tissue0.68694664
131MP0002998_abnormal_bone_remodeling0.68534289
132MP0009931_abnormal_skin_appearance0.68416086
133MP0000598_abnormal_liver_morphology0.68411050
134MP0005174_abnormal_tail_pigmentation0.68233624
135MP0001929_abnormal_gametogenesis0.68158048
136* MP0002925_abnormal_cardiovascular_devel0.66607210
137MP0002160_abnormal_reproductive_system0.65495785
138MP0004883_abnormal_blood_vessel0.64051879
139MP0002970_abnormal_white_adipose0.61795421
140MP0005647_abnormal_sex_gland0.61232910
141MP0009763_increased_sensitivity_to0.60465219
142MP0002876_abnormal_thyroid_physiology0.59916032
143MP0005319_abnormal_enzyme/_coenzyme0.57448294

Predicted human phenotypes

RankGene SetZ-score
1T lymphocytopenia (HP:0005403)5.41838093
2Abnormality of T cell number (HP:0011839)5.09707057
3Abnormality of B cell number (HP:0010975)4.45045445
4B lymphocytopenia (HP:0010976)4.45045445
5Recurrent viral infections (HP:0004429)4.12228977
6Abnormality of the fingertips (HP:0001211)3.92859302
7Panhypogammaglobulinemia (HP:0003139)3.92369908
8Autoimmune hemolytic anemia (HP:0001890)3.85715093
9Thyroiditis (HP:0100646)3.76641922
10Severe combined immunodeficiency (HP:0004430)3.76057707
11Combined immunodeficiency (HP:0005387)3.65139940
12Abnormality of T cells (HP:0002843)3.55744450
13Stomatitis (HP:0010280)3.29439274
14IgM deficiency (HP:0002850)3.29259442
15Hypoplasia of the thymus (HP:0000778)3.25359753
16Eosinophilia (HP:0001880)3.21753611
17Recurrent fungal infections (HP:0002841)3.21215784
18Recurrent bronchitis (HP:0002837)3.18273065
19Abnormality of the columella (HP:0009929)3.12695129
20Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.07777718
21Elevated erythrocyte sedimentation rate (HP:0003565)2.95155922
22Mediastinal lymphadenopathy (HP:0100721)2.95130691
23Verrucae (HP:0200043)2.85387029
24Papilloma (HP:0012740)2.85387029
25Granulocytopenia (HP:0001913)2.72364687
26Abnormality of eosinophils (HP:0001879)2.63782399
27Recurrent bacterial skin infections (HP:0005406)2.63507816
28IgG deficiency (HP:0004315)2.56298045
29Recurrent abscess formation (HP:0002722)2.52019304
30Pustule (HP:0200039)2.51205563
31Agammaglobulinemia (HP:0004432)2.47660401
32Prolonged bleeding time (HP:0003010)2.47509970
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.46768489
34Volvulus (HP:0002580)2.43901541
35Gastrointestinal inflammation (HP:0004386)2.43334185
36Basal cell carcinoma (HP:0002671)2.43278905
37Inflammation of the large intestine (HP:0002037)2.42707024
38Cellulitis (HP:0100658)2.42409593
39Gastrointestinal infarctions (HP:0005244)2.42251674
40Long eyelashes (HP:0000527)2.41223371
41Recurrent skin infections (HP:0001581)2.41123360
42Optic neuritis (HP:0100653)2.40537988
43Retrobulbar optic neuritis (HP:0100654)2.40537988
44Lymphopenia (HP:0001888)2.35414042
45Acute lymphatic leukemia (HP:0006721)2.33211957
46Increased density of long bones (HP:0006392)2.32829728
47Chronic otitis media (HP:0000389)2.32749767
48Meningitis (HP:0001287)2.32402072
49Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.30979489
50Short 4th metacarpal (HP:0010044)2.30979489
51Abnormality of cells of the lymphoid lineage (HP:0012140)2.30219823
52Encephalitis (HP:0002383)2.28438789
53Chromosomal breakage induced by crosslinking agents (HP:0003221)2.26106521
54Aortic aneurysm (HP:0004942)2.25093357
55Leukocytosis (HP:0001974)2.24891580
56Nasal polyposis (HP:0100582)2.23132126
57Chromsome breakage (HP:0040012)2.22078567
58Autoimmune thrombocytopenia (HP:0001973)2.21367937
59Spontaneous hematomas (HP:0007420)2.20906223
60Abnormal platelet volume (HP:0011876)2.18783659
61IgA deficiency (HP:0002720)2.17629748
62Orchitis (HP:0100796)2.17007088
63Colitis (HP:0002583)2.16875223
64Abnormality of T cell physiology (HP:0011840)2.12593628
65Gingival bleeding (HP:0000225)2.11467421
66Chronic obstructive pulmonary disease (HP:0006510)2.08932969
67Obstructive lung disease (HP:0006536)2.08932969
68Lymphoma (HP:0002665)2.08686308
69Albinism (HP:0001022)2.08324669
70Bicuspid aortic valve (HP:0001647)2.07450970
71Clumsiness (HP:0002312)2.06061211
72Abnormality of DNA repair (HP:0003254)2.05019245
73Osteolytic defects of the hand bones (HP:0009699)2.04657476
74Osteolytic defects of the phalanges of the hand (HP:0009771)2.04657476
75Thrombocytosis (HP:0001894)2.04122681
76Deviation of the thumb (HP:0009603)2.03202538
77Hematochezia (HP:0002573)2.01818031
78Abnormality of macrophages (HP:0004311)2.00919273
79Epistaxis (HP:0000421)2.00442867
80Thoracic kyphosis (HP:0002942)1.98262681
81Proximal placement of thumb (HP:0009623)1.97227641
82Pulmonary infiltrates (HP:0002113)1.96129896
83Ulnar bowing (HP:0003031)1.95481014
84Chronic mucocutaneous candidiasis (HP:0002728)1.95355691
85Recurrent cutaneous fungal infections (HP:0011370)1.95355691
86Prominent nose (HP:0000448)1.94952998
87Subacute progressive viral hepatitis (HP:0006572)1.94098884
88Chest pain (HP:0100749)1.93300665
89Increased mean platelet volume (HP:0011877)1.92961185
90Macroorchidism (HP:0000053)1.90717734
91Abnormality of the nasal mucosa (HP:0000433)1.90236874
92Slow saccadic eye movements (HP:0000514)1.89906344
93Cerebral aneurysm (HP:0004944)1.89377458
94Acute myeloid leukemia (HP:0004808)1.88210832
95Hypochromic anemia (HP:0001931)1.88176642
96Keratoconjunctivitis (HP:0001096)1.87045275
97Severe visual impairment (HP:0001141)1.86653253
98Hypoproteinemia (HP:0003075)1.86445779
99Myositis (HP:0100614)1.85126285
100Deep philtrum (HP:0002002)1.83672912
101Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.83395262
102Gastrointestinal stroma tumor (HP:0100723)1.83209524
103Cutis marmorata (HP:0000965)1.83111563
104Chronic diarrhea (HP:0002028)1.83027035
105Aplasia/Hypoplasia of the thymus (HP:0010515)1.82096578
106Hyperacusis (HP:0010780)1.81526321
107Pulmonary embolism (HP:0002204)1.81346026
108Syringomyelia (HP:0003396)1.80856354
109Spinal cord lesions (HP:0100561)1.80856354
110Bronchitis (HP:0012387)1.80614463
111Keratoconjunctivitis sicca (HP:0001097)1.80282037
112Periodontitis (HP:0000704)1.78946119
113Persistence of primary teeth (HP:0006335)1.78779157
114Acute hepatic failure (HP:0006554)1.78627431
115Recurrent sinusitis (HP:0011108)1.78134090
116Increased nuchal translucency (HP:0010880)1.77875279
117Arterial thrombosis (HP:0004420)1.77847721
118Mitral valve prolapse (HP:0001634)1.77111655
119Abnormality of the 4th metacarpal (HP:0010012)1.76813808
120Self-mutilation (HP:0000742)1.75345756
121Increased IgE level (HP:0003212)1.75212165
122Eczematoid dermatitis (HP:0000976)1.74674802
123Vasculitis (HP:0002633)1.74557674
124Recurrent gram-negative bacterial infections (HP:0005420)1.74222766
125Narrow palate (HP:0000189)1.73799840
126Joint swelling (HP:0001386)1.73596627
127Emphysema (HP:0002097)1.73478222
128Clubbing of toes (HP:0100760)1.73075933
129Abnormality of the prostate (HP:0008775)1.72779130
130Hemoptysis (HP:0002105)1.72434851
131Bronchiectasis (HP:0002110)1.70812347
132Acanthocytosis (HP:0001927)1.70731134
133Ectopic kidney (HP:0000086)1.70034387
134Limited elbow extension (HP:0001377)1.68971012
135Spondylolisthesis (HP:0003302)1.68916686
136Abnormality of the thymus (HP:0000777)1.67996444
137Ureteral stenosis (HP:0000071)1.67944608
138Trigonocephaly (HP:0000243)1.67656967
139Rectal prolapse (HP:0002035)1.67502896
140Abnormality of the renal collecting system (HP:0004742)1.67005551
141Dislocated radial head (HP:0003083)1.66045854
142Duplicated collecting system (HP:0000081)1.65961647
143Dilatation of the ascending aorta (HP:0005111)1.65813414
144Abnormal foot bone ossification (HP:0010675)1.65151523
145Myocardial infarction (HP:0001658)1.63817604
146Disproportionate tall stature (HP:0001519)1.63219581
147Viral hepatitis (HP:0006562)1.62689372
148Genetic anticipation (HP:0003743)1.62577676
149High pitched voice (HP:0001620)1.61991526
150Abnormality of oral frenula (HP:0000190)1.60910474

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.01210415
2MAP3K133.49345507
3CDK123.39799136
4MAP3K103.19472076
5EEF2K3.04752761
6STK102.72527888
7PINK12.62482405
8TXK2.58162345
9PKN22.49292283
10TRIB32.37438191
11RIPK42.24148480
12JAK32.15671448
13FES2.05590990
14GRK61.93345752
15ITK1.92171524
16FGFR41.82707072
17CDC71.80095689
18ZAP701.75011974
19LRRK21.74755652
20FGFR31.67336919
21NEK21.64998875
22TYK21.60801428
23ERN11.51685412
24MAP3K11.49626507
25CDK41.47119900
26BTK1.44755146
27SIK11.44373743
28CDK61.44304604
29BRD41.43012646
30CAMK1D1.33340179
31PTK61.32507653
32RPS6KA41.32376145
33SGK21.30764759
34JAK11.28989403
35TTN1.26199903
36TLK11.24542758
37PIM11.20125436
38KSR21.18890408
39CSK1.13089404
40RPS6KB21.11892016
41ZAK1.09404171
42SYK1.08317556
43WNK11.05192483
44OBSCN1.04780515
45LCK1.04506737
46LATS11.04471702
47STK41.03507954
48HCK1.03383188
49NLK1.02940884
50STK31.02039471
51MARK31.02023417
52MAP3K21.02001528
53CSF1R1.01924125
54SGK31.01578990
55EPHB11.01320660
56FLT30.99224560
57TGFBR20.99069282
58PDGFRB0.98711051
59FGFR20.98701851
60MAPKAPK30.98128200
61CAMK1G0.97330304
62CDK90.96666828
63MAP3K80.96157734
64PIK3CG0.95496768
65SGK2230.95154499
66SGK4940.95154499
67MELK0.94847456
68MAP3K70.92868468
69TEC0.90511027
70MTOR0.90499222
71TNK20.89453743
72PDK10.87950560
73MAP3K30.86753329
74PRPF4B0.84240031
75ALK0.81483575
76PASK0.80838396
77MAPK120.79509419
78MAP3K90.79114970
79NUAK10.77719718
80EPHA30.77570143
81MST40.76931818
82MAP2K30.75015835
83ACVR1B0.74795023
84CHUK0.74118547
85RPS6KB10.73547147
86JAK20.70955239
87IKBKE0.70744494
88ATR0.69925742
89TESK20.67121460
90PDGFRA0.66739781
91MAP3K140.66359563
92CHEK10.66300433
93PRKCQ0.65556132
94TBK10.65098955
95SIK20.65028138
96TRPM70.64842691
97TGFBR10.64689355
98CDK30.64260262
99RET0.63758489
100CLK10.63265017
101NEK90.63214639
102DMPK0.62135542
103RIPK10.62100734
104SCYL20.60912972
105PDPK10.60349205
106FGFR10.60006640
107MAPK110.59377087
108CAMKK20.59293879
109KDR0.59173953
110FRK0.58336401
111CDK70.56635845
112TAOK30.55994171
113AURKB0.53745685
114HIPK20.53239084
115IRAK40.52224213
116GRK10.51796838
117KIT0.51541266
118RAF10.50263401
119ATM0.50127865
120PRKCH0.49532058
121EIF2AK30.49156573
122TAOK10.48537834
123BLK0.47972367
124NME20.47113153
125IKBKB0.46973031
126ICK0.46480173
127PAK20.45509806
128BMPR1B0.44861561
129LYN0.44815209
130PTK2B0.43704225
131BMX0.42078341
132PRKAA20.41518755
133MARK20.41395437
134TTK0.41226007
135MOS0.41169273
136DYRK1B0.40649026
137* CDK20.40414977
138PAK40.39759252
139MAPK70.38513033
140EGFR0.37913481
141SGK10.36939720
142BRSK20.36085785
143ADRBK20.36035230
144MATK0.35512106
145TYRO30.35274374

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.35698425
2Antigen processing and presentation_Homo sapiens_hsa046122.30720838
3* T cell receptor signaling pathway_Homo sapiens_hsa046602.28728508
4Autoimmune thyroid disease_Homo sapiens_hsa053202.18947446
5NF-kappa B signaling pathway_Homo sapiens_hsa040641.97293701
6* B cell receptor signaling pathway_Homo sapiens_hsa046621.95796571
7Intestinal immune network for IgA production_Homo sapiens_hsa046721.92808766
8Measles_Homo sapiens_hsa051621.81639005
9Chronic myeloid leukemia_Homo sapiens_hsa052201.80208492
10Non-homologous end-joining_Homo sapiens_hsa034501.79731338
11Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.73982862
12Hematopoietic cell lineage_Homo sapiens_hsa046401.63783011
13Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.61066446
14Lysine degradation_Homo sapiens_hsa003101.60184062
15Acute myeloid leukemia_Homo sapiens_hsa052211.53649732
16Type I diabetes mellitus_Homo sapiens_hsa049401.53033004
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.51974083
18Osteoclast differentiation_Homo sapiens_hsa043801.51578479
19DNA replication_Homo sapiens_hsa030301.50426202
20Leishmaniasis_Homo sapiens_hsa051401.49105148
21Herpes simplex infection_Homo sapiens_hsa051681.46303875
22Viral myocarditis_Homo sapiens_hsa054161.45767542
23Small cell lung cancer_Homo sapiens_hsa052221.40293266
24Cell cycle_Homo sapiens_hsa041101.39309007
25Viral carcinogenesis_Homo sapiens_hsa052031.34445815
26Jak-STAT signaling pathway_Homo sapiens_hsa046301.30120502
27MicroRNAs in cancer_Homo sapiens_hsa052061.26389064
28* HTLV-I infection_Homo sapiens_hsa051661.26237083
29Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.24992282
30Toxoplasmosis_Homo sapiens_hsa051451.24844863
31Pancreatic cancer_Homo sapiens_hsa052121.24541705
32One carbon pool by folate_Homo sapiens_hsa006701.20446386
33Non-small cell lung cancer_Homo sapiens_hsa052231.18813133
34Mismatch repair_Homo sapiens_hsa034301.18437203
35* Hepatitis B_Homo sapiens_hsa051611.17883543
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.16833740
37Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16616740
38Spliceosome_Homo sapiens_hsa030401.16234082
39Adherens junction_Homo sapiens_hsa045201.15558672
40p53 signaling pathway_Homo sapiens_hsa041151.15384944
41Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.13665081
42Olfactory transduction_Homo sapiens_hsa047401.10108256
43RNA transport_Homo sapiens_hsa030131.07281966
44Colorectal cancer_Homo sapiens_hsa052101.07035345
45Thyroid cancer_Homo sapiens_hsa052161.04613484
46Prostate cancer_Homo sapiens_hsa052151.02334328
47mRNA surveillance pathway_Homo sapiens_hsa030151.01671398
48Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00964236
49Apoptosis_Homo sapiens_hsa042101.00147404
50Base excision repair_Homo sapiens_hsa034100.99743430
51Notch signaling pathway_Homo sapiens_hsa043300.96051452
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.95836698
53Platelet activation_Homo sapiens_hsa046110.94904605
54Epstein-Barr virus infection_Homo sapiens_hsa051690.93860183
55AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.92484155
56Proteoglycans in cancer_Homo sapiens_hsa052050.90582387
57mTOR signaling pathway_Homo sapiens_hsa041500.89362272
58FoxO signaling pathway_Homo sapiens_hsa040680.86820948
59Insulin resistance_Homo sapiens_hsa049310.86150715
60NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85772196
61Influenza A_Homo sapiens_hsa051640.85295822
62Endometrial cancer_Homo sapiens_hsa052130.84974818
63Shigellosis_Homo sapiens_hsa051310.84776456
64Fanconi anemia pathway_Homo sapiens_hsa034600.84241059
65Asthma_Homo sapiens_hsa053100.83416244
66Glioma_Homo sapiens_hsa052140.82349847
67Chemokine signaling pathway_Homo sapiens_hsa040620.79231158
68RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78811067
69Graft-versus-host disease_Homo sapiens_hsa053320.76682247
70Staphylococcus aureus infection_Homo sapiens_hsa051500.75886327
71Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.75853289
72TNF signaling pathway_Homo sapiens_hsa046680.75663472
73Allograft rejection_Homo sapiens_hsa053300.74800609
74Systemic lupus erythematosus_Homo sapiens_hsa053220.73617316
75Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.71305631
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.70220890
77Focal adhesion_Homo sapiens_hsa045100.69308081
78Toll-like receptor signaling pathway_Homo sapiens_hsa046200.69098727
79Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.68167630
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.67649141
81Renin secretion_Homo sapiens_hsa049240.67261758
82RNA degradation_Homo sapiens_hsa030180.67198917
83Renal cell carcinoma_Homo sapiens_hsa052110.65987610
84Pathways in cancer_Homo sapiens_hsa052000.65590091
85Caffeine metabolism_Homo sapiens_hsa002320.65290627
86Hepatitis C_Homo sapiens_hsa051600.63849192
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63775560
88Choline metabolism in cancer_Homo sapiens_hsa052310.63772728
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.63548243
90VEGF signaling pathway_Homo sapiens_hsa043700.61794231
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61309989
92Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.61202745
93Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.60899232
94Prolactin signaling pathway_Homo sapiens_hsa049170.60650624
95Circadian rhythm_Homo sapiens_hsa047100.60559076
96Selenocompound metabolism_Homo sapiens_hsa004500.59880500
97Ribosome_Homo sapiens_hsa030100.59397070
98ABC transporters_Homo sapiens_hsa020100.58942550
99Legionellosis_Homo sapiens_hsa051340.58081232
100Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56686699
101Glycerophospholipid metabolism_Homo sapiens_hsa005640.55813178
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53461648
103Malaria_Homo sapiens_hsa051440.52914344
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.52541706
105Insulin signaling pathway_Homo sapiens_hsa049100.51042617
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.49974931
107Phototransduction_Homo sapiens_hsa047440.49648882
108Type II diabetes mellitus_Homo sapiens_hsa049300.49624036
109Regulation of autophagy_Homo sapiens_hsa041400.49522642
110Central carbon metabolism in cancer_Homo sapiens_hsa052300.49389047
111Tuberculosis_Homo sapiens_hsa051520.48682210
112Homologous recombination_Homo sapiens_hsa034400.47951958
113HIF-1 signaling pathway_Homo sapiens_hsa040660.47535860
114Inositol phosphate metabolism_Homo sapiens_hsa005620.47203407
115Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46582517
116Nitrogen metabolism_Homo sapiens_hsa009100.45595640
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45379547
118TGF-beta signaling pathway_Homo sapiens_hsa043500.45375923
119Dorso-ventral axis formation_Homo sapiens_hsa043200.45109625
120Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44091734
121Chemical carcinogenesis_Homo sapiens_hsa052040.43909808
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43698060
123Alcoholism_Homo sapiens_hsa050340.43540182
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.43167614
125Nucleotide excision repair_Homo sapiens_hsa034200.43133870
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.42803835
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.41811466
128GnRH signaling pathway_Homo sapiens_hsa049120.41800877
129Basal cell carcinoma_Homo sapiens_hsa052170.41678897
130Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40458317
131Long-term potentiation_Homo sapiens_hsa047200.39813931
132Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34855790
133Glucagon signaling pathway_Homo sapiens_hsa049220.30015463

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