NFATC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the nuclear factor of activated T cells (NFAT) protein family. The encoded protein is part of a DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor stimulation and an inducible nuclear component. NFAT proteins are activated by the calmodulin-dependent phosphatase, calcineurin. The encoded protein plays a role in the inducible expression of cytokine genes in T cells, especially in the induction of interleukin-2 and interleukin-4. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1bone trabecula formation (GO:0060346)7.71486720
2protein heterotrimerization (GO:0070208)5.94650768
3cardiac right ventricle morphogenesis (GO:0003215)5.70908188
4embryonic camera-type eye development (GO:0031076)5.45014201
5planar cell polarity pathway involved in neural tube closure (GO:0090179)4.88406087
6lateral sprouting from an epithelium (GO:0060601)4.78913073
7tooth mineralization (GO:0034505)4.76544524
8collagen fibril organization (GO:0030199)4.74549931
9mesenchymal-epithelial cell signaling (GO:0060638)4.65002191
10regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.55534979
11chondrocyte proliferation (GO:0035988)4.47501728
12craniofacial suture morphogenesis (GO:0097094)4.28888838
13paraxial mesoderm development (GO:0048339)4.12590780
14neuron projection extension involved in neuron projection guidance (GO:1902284)4.00283571
15axon extension involved in axon guidance (GO:0048846)4.00283571
16outer ear morphogenesis (GO:0042473)3.96752494
17endodermal cell differentiation (GO:0035987)3.87858858
18cytoskeletal anchoring at plasma membrane (GO:0007016)3.80207670
19glomerular basement membrane development (GO:0032836)3.76720721
20polarized epithelial cell differentiation (GO:0030859)3.73158933
21sequestering of extracellular ligand from receptor (GO:0035581)3.72957652
22negative regulation of chondrocyte differentiation (GO:0032331)3.71584014
23skin morphogenesis (GO:0043589)3.64009168
24extracellular matrix assembly (GO:0085029)3.62291948
25middle ear morphogenesis (GO:0042474)3.60189722
26cell migration involved in heart development (GO:0060973)3.58329037
27cell proliferation involved in metanephros development (GO:0072203)3.54317354
28regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.51054875
29dermatan sulfate metabolic process (GO:0030205)3.46348751
30G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.41028348
31embryonic cranial skeleton morphogenesis (GO:0048701)3.40443622
32extracellular fibril organization (GO:0043206)3.39580351
33regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.39412543
34vascular endothelial growth factor signaling pathway (GO:0038084)3.38786321
35metanephric mesenchyme development (GO:0072075)3.32823838
36hippo signaling (GO:0035329)3.32388255
37eyelid development in camera-type eye (GO:0061029)3.30863818
38cranial suture morphogenesis (GO:0060363)3.30436195
39Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.28957958
40hematopoietic stem cell proliferation (GO:0071425)3.27868410
41mesenchymal cell proliferation (GO:0010463)3.27363640
42negative regulation of fatty acid transport (GO:2000192)3.27306303
43negative regulation of embryonic development (GO:0045992)3.26397729
44collagen metabolic process (GO:0032963)3.23657106
45collagen catabolic process (GO:0030574)3.17308654
46dermatan sulfate biosynthetic process (GO:0030208)3.16929067
47convergent extension (GO:0060026)3.16907598
48wound healing, spreading of epidermal cells (GO:0035313)3.16432262
49regulation of establishment of planar polarity (GO:0090175)3.15881985
50negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.14566396
51positive regulation of smoothened signaling pathway (GO:0045880)3.14473684
52kidney mesenchyme development (GO:0072074)3.14297556
53negative regulation of cartilage development (GO:0061037)3.14153623
54peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.13723580
55extracellular matrix disassembly (GO:0022617)3.12558892
56positive regulation of bone mineralization (GO:0030501)3.12486258
57non-canonical Wnt signaling pathway (GO:0035567)3.11941247
58cardiac ventricle morphogenesis (GO:0003208)3.11403175
59camera-type eye morphogenesis (GO:0048593)3.11364996
60embryonic skeletal joint morphogenesis (GO:0060272)3.09478121
61secondary heart field specification (GO:0003139)3.06205920
62heart field specification (GO:0003128)3.06205920
63trabecula formation (GO:0060343)3.05993892
64negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.05531183
65type B pancreatic cell proliferation (GO:0044342)3.05513189
66radial glial cell differentiation (GO:0060019)3.05398377
67cochlea morphogenesis (GO:0090103)3.04153235
68endocardial cushion development (GO:0003197)3.03883033
69blood vessel maturation (GO:0001955)3.03329852
70anatomical structure regression (GO:0060033)3.02615018
71mesodermal cell differentiation (GO:0048333)3.02471759
72cell migration involved in sprouting angiogenesis (GO:0002042)3.02277419
73regulation of heart morphogenesis (GO:2000826)3.02273229
74basement membrane organization (GO:0071711)3.02195491
75molting cycle (GO:0042303)3.01374682
76hair cycle (GO:0042633)3.01374682
77aorta morphogenesis (GO:0035909)3.00833474
78multicellular organismal macromolecule metabolic process (GO:0044259)3.00372078
79epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.00272251
80regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.00238884
81regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.00187686
82head development (GO:0060322)3.00122281
83positive regulation of biomineral tissue development (GO:0070169)2.98749449
84embryonic forelimb morphogenesis (GO:0035115)2.98733849
85endothelial cell chemotaxis (GO:0035767)2.97492294
86establishment of planar polarity (GO:0001736)2.97378823
87establishment of tissue polarity (GO:0007164)2.97378823
88negative regulation of axon extension involved in axon guidance (GO:0048843)2.95766962
89positive regulation of endothelial cell apoptotic process (GO:2000353)2.95439351
90embryonic hindlimb morphogenesis (GO:0035116)2.94658182
91nodal signaling pathway (GO:0038092)2.94605966
92axis elongation (GO:0003401)2.92132579
93cardiac chamber morphogenesis (GO:0003206)2.91543264
94cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.91181685
95chondrocyte development (GO:0002063)2.90958972
96establishment of apical/basal cell polarity (GO:0035089)2.90917783
97virion attachment to host cell (GO:0019062)2.90590991
98adhesion of symbiont to host cell (GO:0044650)2.90590991
99mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.90298708
100hindlimb morphogenesis (GO:0035137)2.88833592
101positive regulation of gastrulation (GO:2000543)2.88617498
102multicellular organismal catabolic process (GO:0044243)2.86830061
103midgut development (GO:0007494)2.86075290
104glial cell migration (GO:0008347)2.86064589
105cell proliferation involved in kidney development (GO:0072111)2.85179020
106positive regulation of mesenchymal cell proliferation (GO:0002053)2.84793601
107regulation of hair follicle development (GO:0051797)2.84362572
108proximal/distal pattern formation (GO:0009954)2.84034016
109eye morphogenesis (GO:0048592)2.83873178
110fibril organization (GO:0097435)2.83227696
111multicellular organismal metabolic process (GO:0044236)2.80987542
112organ induction (GO:0001759)2.80507364
113regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.79549687
114endothelial cell morphogenesis (GO:0001886)2.78782974
115axon extension (GO:0048675)2.78772323
116positive regulation of epithelial to mesenchymal transition (GO:0010718)2.76830136
117regulation of axon extension involved in axon guidance (GO:0048841)2.76786907
118positive regulation of SMAD protein import into nucleus (GO:0060391)2.75643865
119regulation of gastrulation (GO:0010470)2.75251842
120negative regulation of osteoblast proliferation (GO:0033689)2.75243638
121mesenchyme morphogenesis (GO:0072132)2.74444550
122cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.72952734
123peptidyl-proline hydroxylation (GO:0019511)2.72932172
124bone morphogenesis (GO:0060349)2.72758767
125positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.72512237
126cartilage morphogenesis (GO:0060536)2.72104493
127muscle cell migration (GO:0014812)2.71578673
128regulation of cartilage development (GO:0061035)2.68650091
129extracellular matrix organization (GO:0030198)2.68416166
130epithelial to mesenchymal transition (GO:0001837)2.68348848
131negative regulation of smooth muscle cell migration (GO:0014912)2.67919606
132positive regulation of extracellular matrix organization (GO:1903055)2.67634746
133negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.67574296
134negative regulation of catenin import into nucleus (GO:0035414)2.67446612
135extracellular structure organization (GO:0043062)2.67434156
136lymph vessel development (GO:0001945)2.66612943
137negative regulation of axon guidance (GO:1902668)2.66597097
138regulation of chondrocyte differentiation (GO:0032330)2.66316259
139venous blood vessel morphogenesis (GO:0048845)2.65750739
140artery morphogenesis (GO:0048844)2.63682429
141adherens junction assembly (GO:0034333)2.62169408
142adhesion of symbiont to host (GO:0044406)2.61886808
143regulation of mesenchymal cell proliferation (GO:0010464)2.61373422
144positive regulation of cartilage development (GO:0061036)2.60178820
145regulation of axon guidance (GO:1902667)2.60145236
146negative regulation of BMP signaling pathway (GO:0030514)2.60088078
147branching involved in salivary gland morphogenesis (GO:0060445)2.59488599
148atrial septum morphogenesis (GO:0060413)2.58301878
149regulation of organ formation (GO:0003156)2.58228831
150vasculature development (GO:0001944)2.57773751
151notochord development (GO:0030903)2.57524498
152lung-associated mesenchyme development (GO:0060484)2.57252030

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.97224839
2RARG_19884340_ChIP-ChIP_MEFs_Mouse3.56069838
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.49078144
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.01822645
5EGR1_19374776_ChIP-ChIP_THP-1_Human2.94520530
6TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.76896473
7EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.67082769
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.60650027
9NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.47897369
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.45283750
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.45138002
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.44936638
13ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.44778707
14* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.38862786
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.38514606
16TP53_20018659_ChIP-ChIP_R1E_Mouse2.35020135
17* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.27993802
18CLOCK_20551151_ChIP-Seq_293T_Human2.25986421
19* SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.24183979
20HIF1A_21447827_ChIP-Seq_MCF-7_Human2.09185759
21* TP63_19390658_ChIP-ChIP_HaCaT_Human2.04108298
22WT1_19549856_ChIP-ChIP_CCG9911_Human2.03619974
23ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.00371833
24EZH2_22144423_ChIP-Seq_EOC_Human2.00181484
25CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.99943747
26FOXM1_23109430_ChIP-Seq_U2OS_Human1.99841136
27PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.96857946
28* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.95538112
29* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.95114581
30RNF2_18974828_ChIP-Seq_MESCs_Mouse1.92190562
31EZH2_18974828_ChIP-Seq_MESCs_Mouse1.92190562
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91432243
33SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.89835842
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.88412731
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.87489582
36EZH2_27294783_Chip-Seq_ESCs_Mouse1.80519078
37E2F7_22180533_ChIP-Seq_HELA_Human1.77127119
38EP300_21415370_ChIP-Seq_HL-1_Mouse1.75884329
39* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.74997704
40EZH2_27304074_Chip-Seq_ESCs_Mouse1.74431933
41TCF3_18692474_ChIP-Seq_MEFs_Mouse1.73463781
42KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.72492150
43KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.72492150
44KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.72492150
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.71162490
46* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.70573511
47SOX2_18555785_ChIP-Seq_MESCs_Mouse1.68082721
48* BRD4_25478319_ChIP-Seq_HGPS_Human1.66004169
49ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.65741343
50ESR1_21235772_ChIP-Seq_MCF-7_Human1.63295836
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.61098853
52* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.58149895
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.57680436
54* ISL1_27105846_Chip-Seq_CPCs_Mouse1.56337110
55* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.55929691
56* ELK3_25401928_ChIP-Seq_HUVEC_Human1.54134439
57RING1B_27294783_Chip-Seq_NPCs_Mouse1.52821445
58* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.51967115
59TCF3_18692474_ChIP-Seq_MESCs_Mouse1.51642175
60MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51366340
61* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.48800045
62HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.46518721
63SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.45665471
64TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.44980020
65SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.43484243
66RNF2_27304074_Chip-Seq_ESCs_Mouse1.42780207
67SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.42530479
68CBX2_27304074_Chip-Seq_ESCs_Mouse1.41890773
69* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.41164054
70JARID2_20075857_ChIP-Seq_MESCs_Mouse1.40777962
71KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40338768
72SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.37305088
73SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.37305088
74* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.35204808
75JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34690797
76LXR_22292898_ChIP-Seq_THP-1_Human1.33830959
77SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.33667123
78ESR2_21235772_ChIP-Seq_MCF-7_Human1.32954433
79SA1_22415368_ChIP-Seq_MEFs_Mouse1.32781110
80SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.31756164
81CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29040270
82* RACK7_27058665_Chip-Seq_MCF-7_Human1.27819181
83* CTCF_27219007_Chip-Seq_Bcells_Human1.26210732
84CJUN_26792858_Chip-Seq_BT549_Human1.25499891
85TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25490584
86EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.24951951
87SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.24382416
88DROSHA_22980978_ChIP-Seq_HELA_Human1.22525714
89SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.21960664
90ESR1_15608294_ChIP-ChIP_MCF-7_Human1.21921015
91* KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.21311419
92NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.21188939
93* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21062328
94* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.20490666
95ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.18706789
96* ATF3_27146783_Chip-Seq_COLON_Human1.14463695
97TP53_22127205_ChIP-Seq_IMR90_Human1.13713578
98* RING1B_27294783_Chip-Seq_ESCs_Mouse1.13532935
99TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.13372623
100NANOG_16153702_ChIP-ChIP_HESCs_Human1.12194054
101TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.10670564
102STAT3_19079543_ChIP-ChIP_MESCs_Mouse1.10633951
103OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.10495582
104* KDM2B_26808549_Chip-Seq_JURKAT_Human1.10264445
105NRF2_20460467_ChIP-Seq_MEFs_Mouse1.09081545
106NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.09081545
107KDM2B_26808549_Chip-Seq_DND41_Human1.08827593
108NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08174404
109UBF1/2_26484160_Chip-Seq_HMECs_Human1.08131281
110* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.07947555
111SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07165369
112* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.05166542
113RBPJ_22232070_ChIP-Seq_NCS_Mouse1.03102651
114SOX9_24532713_ChIP-Seq_HFSC_Mouse1.03087170
115* SA1_27219007_Chip-Seq_ERYTHROID_Human1.02224354
116SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02137348
117POU5F1_16153702_ChIP-ChIP_HESCs_Human1.01483091
118GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.00478438
119POU5F1_16518401_ChIP-PET_MESCs_Mouse1.00257520
120* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99967650
121RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99653836
122POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.98857104
123TP53_23651856_ChIP-Seq_MEFs_Mouse0.98634688
124TBX20_22328084_ChIP-Seq_HEART_Mouse0.98539332
125TBX20_22080862_ChIP-Seq_HEART_Mouse0.98539332
126ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.97838492
127TP53_18474530_ChIP-ChIP_U2OS_Human0.97043914
128TET1_21490601_ChIP-Seq_MESCs_Mouse0.96319124
129EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95875521
130KDM2B_26808549_Chip-Seq_K562_Human0.95226810
131* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94716324
132MYC_27129775_Chip-Seq_CORNEA_Mouse0.93224492

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.52747092
2MP0005503_abnormal_tendon_morphology4.28918795
3MP0003705_abnormal_hypodermis_morpholog4.03524878
4MP0005275_abnormal_skin_tensile3.49197970
5MP0010030_abnormal_orbit_morphology3.17780387
6MP0009053_abnormal_anal_canal2.99582627
7MP0003279_aneurysm2.82170471
8MP0003385_abnormal_body_wall2.72669518
9MP0005257_abnormal_intraocular_pressure2.64862469
10MP0000537_abnormal_urethra_morphology2.47848785
11MP0009250_abnormal_appendicular_skeleto2.45920164
12MP0004272_abnormal_basement_membrane2.43217187
13MP0001299_abnormal_eye_distance/2.19612879
14MP0003122_maternal_imprinting2.17323387
15MP0005508_abnormal_skeleton_morphology2.15111126
16MP0003123_paternal_imprinting2.07013753
17MP0003942_abnormal_urinary_system1.99611501
18MP0001958_emphysema1.98159678
19MP0000049_abnormal_middle_ear1.94857007
20MP0000733_abnormal_muscle_development1.87986545
21MP0009384_cardiac_valve_regurgitation1.86510252
22MP0000751_myopathy1.85705337
23MP0000428_abnormal_craniofacial_morphol1.84087896
24MP0003937_abnormal_limbs/digits/tail_de1.84015010
25MP0005187_abnormal_penis_morphology1.83454442
26MP0003941_abnormal_skin_development1.80792056
27MP0002249_abnormal_larynx_morphology1.79467731
28MP0002282_abnormal_trachea_morphology1.76785972
29MP0006054_spinal_hemorrhage1.76561083
30MP0005623_abnormal_meninges_morphology1.76309652
31MP0002932_abnormal_joint_morphology1.74750272
32MP0000534_abnormal_ureter_morphology1.74657244
33MP0003755_abnormal_palate_morphology1.73837478
34MP0003121_genomic_imprinting1.56026252
35MP0005076_abnormal_cell_differentiation1.51549867
36MP0003935_abnormal_craniofacial_develop1.49278900
37MP0002896_abnormal_bone_mineralization1.47390795
38MP0002108_abnormal_muscle_morphology1.46793218
39MP0000762_abnormal_tongue_morphology1.42572645
40MP0002116_abnormal_craniofacial_bone1.40191497
41MP0000163_abnormal_cartilage_morphology1.37480176
42MP0003283_abnormal_digestive_organ1.37291567
43MP0002115_abnormal_skeleton_extremities1.36163334
44MP0003566_abnormal_cell_adhesion1.36008179
45MP0005248_abnormal_Harderian_gland1.35089640
46MP0003115_abnormal_respiratory_system1.31739486
47MP0000432_abnormal_head_morphology1.30305341
48MP0010352_gastrointestinal_tract_polyps1.29743695
49MP0005023_abnormal_wound_healing1.27031325
50MP0002060_abnormal_skin_morphology1.26718228
51MP0005367_renal/urinary_system_phenotyp1.26519861
52MP0000516_abnormal_urinary_system1.26519861
53MP0002109_abnormal_limb_morphology1.26182141
54MP0000013_abnormal_adipose_tissue1.26141055
55MP0002111_abnormal_tail_morphology1.25840907
56MP0000750_abnormal_muscle_regeneration1.25111521
57MP0002938_white_spotting1.24320835
58MP0010368_abnormal_lymphatic_system1.23781763
59MP0009379_abnormal_foot_pigmentation1.19314125
60MP0006138_congestive_heart_failure1.19048235
61MP0002233_abnormal_nose_morphology1.17550622
62MP0001340_abnormal_eyelid_morphology1.15500289
63MP0002113_abnormal_skeleton_development1.14954922
64MP0000566_synostosis1.13998195
65MP0004133_heterotaxia1.13383797
66MP0003878_abnormal_ear_physiology1.13251795
67MP0005377_hearing/vestibular/ear_phenot1.13251795
68MP0002295_abnormal_pulmonary_circulatio1.09881596
69MP0004134_abnormal_chest_morphology1.09566564
70MP0002114_abnormal_axial_skeleton1.08280637
71MP0002089_abnormal_postnatal_growth/wei1.08063177
72MP0004197_abnormal_fetal_growth/weight/1.06184088
73MP0001879_abnormal_lymphatic_vessel1.03582503
74MP0002102_abnormal_ear_morphology1.02441878
75MP0005390_skeleton_phenotype1.02253766
76MP0003119_abnormal_digestive_system1.00913078
77MP0005595_abnormal_vascular_smooth1.00590634
78MP0000767_abnormal_smooth_muscle0.99584815
79MP0002177_abnormal_outer_ear0.99402859
80MP0000579_abnormal_nail_morphology0.97073706
81MP0001243_abnormal_dermal_layer0.96573652
82MP0001348_abnormal_lacrimal_gland0.96183002
83MP0003890_abnormal_embryonic-extraembry0.95162418
84MP0000778_abnormal_nervous_system0.90383739
85MP0002697_abnormal_eye_size0.89587488
86MP0002085_abnormal_embryonic_tissue0.87905840
87MP0001293_anophthalmia0.87509050
88MP0000462_abnormal_digestive_system0.84589036
89MP0003938_abnormal_ear_development0.84508743
90MP0002925_abnormal_cardiovascular_devel0.83441235
91MP0006292_abnormal_olfactory_placode0.82163298
92MP0008789_abnormal_olfactory_epithelium0.80975826
93MP0003091_abnormal_cell_migration0.80817903
94MP0000003_abnormal_adipose_tissue0.80466503
95MP0002084_abnormal_developmental_patter0.79677242
96MP0001270_distended_abdomen0.79187551
97MP0001915_intracranial_hemorrhage0.79007510
98MP0000759_abnormal_skeletal_muscle0.78361000
99MP0002092_abnormal_eye_morphology0.77858920
100MP0001175_abnormal_lung_morphology0.77517992
101MP0009703_decreased_birth_body0.76681092
102MP0001849_ear_inflammation0.76390225
103MP0004858_abnormal_nervous_system0.75166063
104MP0005197_abnormal_uvea_morphology0.75127256
105MP0001542_abnormal_bone_strength0.74833217
106MP0001614_abnormal_blood_vessel0.74408664
107MP0003315_abnormal_perineum_morphology0.72416626
108MP0005193_abnormal_anterior_eye0.71971667
109MP0001346_abnormal_lacrimal_gland0.68983868
110MP0002933_joint_inflammation0.67030014
111MP0000026_abnormal_inner_ear0.66124041
112MP0000613_abnormal_salivary_gland0.66081652
113MP0002254_reproductive_system_inflammat0.65587053
114MP0003448_altered_tumor_morphology0.65403213
115MP0005171_absent_coat_pigmentation0.64878654
116MP0009780_abnormal_chondrocyte_physiolo0.64712658
117MP0002128_abnormal_blood_circulation0.63032362
118MP0002081_perinatal_lethality0.62680476
119MP0003567_abnormal_fetal_cardiomyocyte0.62136333
120MP0001286_abnormal_eye_development0.61893388
121MP0005369_muscle_phenotype0.61767920
122MP0003861_abnormal_nervous_system0.60712461
123MP0005394_taste/olfaction_phenotype0.56318904

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.56730659
2Premature rupture of membranes (HP:0001788)5.37923240
3Shallow orbits (HP:0000586)4.57504184
4Short 4th metacarpal (HP:0010044)4.19128977
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)4.19128977
6Turricephaly (HP:0000262)3.98425321
7Ankle contracture (HP:0006466)3.84308663
8Abnormality of the 4th metacarpal (HP:0010012)3.59988147
9Broad metatarsal (HP:0001783)3.56329917
10Aortic dissection (HP:0002647)3.45754007
11Bladder diverticulum (HP:0000015)3.38574756
12Soft skin (HP:0000977)3.34135358
13Fragile skin (HP:0001030)3.32693860
14Atrophic scars (HP:0001075)3.19088332
15Peritonitis (HP:0002586)3.17979145
16Neonatal short-limb short stature (HP:0008921)3.10701969
17Mesomelia (HP:0003027)3.00996195
18Aortic regurgitation (HP:0001659)2.78433523
19Blue sclerae (HP:0000592)2.74525828
20Abnormality of the parietal bone (HP:0002696)2.74023761
21Natal tooth (HP:0000695)2.71292656
22Dilatation of the ascending aorta (HP:0005111)2.71083099
23Mitral regurgitation (HP:0001653)2.70935933
24Cerebral aneurysm (HP:0004944)2.70032591
25Coronal craniosynostosis (HP:0004440)2.69890529
26Aortic aneurysm (HP:0004942)2.68567680
27Type 1 muscle fiber predominance (HP:0003803)2.68469364
28Follicular hyperkeratosis (HP:0007502)2.67317376
29Wormian bones (HP:0002645)2.65905932
30Abnormality of dentin (HP:0010299)2.65690547
31Broad toe (HP:0001837)2.61341642
32Cervical subluxation (HP:0003308)2.58677794
33Wrist flexion contracture (HP:0001239)2.58673166
34Genu recurvatum (HP:0002816)2.56612013
35Deviation of the hallux (HP:0010051)2.54435040
36Mitral valve prolapse (HP:0001634)2.52469623
37Increased variability in muscle fiber diameter (HP:0003557)2.50333804
38Hypoventilation (HP:0002791)2.49561255
39Renal duplication (HP:0000075)2.47801208
40Wide anterior fontanel (HP:0000260)2.47519974
41Mildly elevated creatine phosphokinase (HP:0008180)2.44262906
42Midline defect of the nose (HP:0004122)2.40943048
43Long toe (HP:0010511)2.40733210
44Bowel diverticulosis (HP:0005222)2.37319420
45Oligodactyly (HP:0012165)2.37055001
46Vertebral compression fractures (HP:0002953)2.35959105
47Calcaneovalgus deformity (HP:0001848)2.35887085
48Hallux valgus (HP:0001822)2.35450975
49Deformed tarsal bones (HP:0008119)2.32980120
50Broad hallux (HP:0010055)2.28005978
51Hyperextensible skin (HP:0000974)2.27814322
52Round ear (HP:0100830)2.26360560
53Biconcave vertebral bodies (HP:0004586)2.24986748
54Mild short stature (HP:0003502)2.24163976
55Aortic valve stenosis (HP:0001650)2.23456916
56Choanal stenosis (HP:0000452)2.20612686
57Short middle phalanx of the 5th finger (HP:0004220)2.20533953
58Vascular tortuosity (HP:0004948)2.17910818
59Broad long bones (HP:0005622)2.16433218
60Protruding ear (HP:0000411)2.15953754
61Breech presentation (HP:0001623)2.15663735
62Short 5th finger (HP:0009237)2.14143022
63Spinal rigidity (HP:0003306)2.10587079
64Broad thumb (HP:0011304)2.10563036
65Ulnar bowing (HP:0003031)2.09219148
66Elbow flexion contracture (HP:0002987)2.07673252
67Disproportionate tall stature (HP:0001519)2.05720405
68Spondylolisthesis (HP:0003302)2.03973212
69Partial duplication of thumb phalanx (HP:0009944)2.02667139
70Abnormality of the distal phalanx of the thumb (HP:0009617)2.02596278
71Inguinal hernia (HP:0000023)2.00840859
72Morphological abnormality of the middle ear (HP:0008609)2.00380706
73Arterial tortuosity (HP:0005116)2.00191953
74Limited elbow extension (HP:0001377)2.00159547
75Narrow nasal bridge (HP:0000446)1.97859110
76Joint stiffness (HP:0001387)1.97805653
77Obstructive sleep apnea (HP:0002870)1.96945301
78Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.96071406
79Slender build (HP:0001533)1.95715199
80Broad ribs (HP:0000885)1.95487241
81Pulmonary artery stenosis (HP:0004415)1.95204488
82Asymmetry of the thorax (HP:0001555)1.95174221
83Flat cornea (HP:0007720)1.94705765
84Joint laxity (HP:0001388)1.92873518
85Abnormality of the calcaneus (HP:0008364)1.92318303
86Abnormality of skeletal muscle fiber size (HP:0012084)1.92061889
87Selective tooth agenesis (HP:0001592)1.91239595
88Partial duplication of the phalanx of hand (HP:0009999)1.91052453
89Abnormal delivery (HP:0001787)1.90356852
90Increased connective tissue (HP:0009025)1.89951486
91Exostoses (HP:0100777)1.88392077
92Broad phalanx (HP:0006009)1.88316172
93Camptodactyly of toe (HP:0001836)1.87353258
94Buphthalmos (HP:0000557)1.86732848
95Hyperacusis (HP:0010780)1.85946516
96Abnormality of the peritoneum (HP:0002585)1.84569510
97Ectopia lentis (HP:0001083)1.83838416
98Delayed cranial suture closure (HP:0000270)1.83268863
99Abnormality of the 2nd finger (HP:0004100)1.83244862
100Broad phalanges of the hand (HP:0009768)1.82189509
101Mixed hearing impairment (HP:0000410)1.81873172
102Thin bony cortex (HP:0002753)1.81466577
103Osteoarthritis (HP:0002758)1.80872567
104Tarsal synostosis (HP:0008368)1.80869978
105Hypoplasia of the iris (HP:0007676)1.80169801
106Abnormality of the acetabulum (HP:0003170)1.79645822
107Midface retrusion (HP:0011800)1.79538796
108Aneurysm (HP:0002617)1.79429019
109Broad finger (HP:0001500)1.78816622
110Limited hip movement (HP:0008800)1.78532839
111Bell-shaped thorax (HP:0001591)1.78165448
112Infantile muscular hypotonia (HP:0008947)1.77625792
113Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.74131532
114Syringomyelia (HP:0003396)1.72590064
115Spinal cord lesions (HP:0100561)1.72590064
116Neonatal death (HP:0003811)1.72498759
117Striae distensae (HP:0001065)1.72435135
118Vitreoretinal degeneration (HP:0000655)1.71182125
119Homocystinuria (HP:0002156)1.70911668
120Abnormality of homocysteine metabolism (HP:0010919)1.70911668
121Venous insufficiency (HP:0005293)1.70292790
122Advanced eruption of teeth (HP:0006288)1.69753043
123Hip contracture (HP:0003273)1.69533710
124Abnormality of the phalanges of the hallux (HP:0010057)1.68703245
125Knee flexion contracture (HP:0006380)1.68695106
126Short nail (HP:0001799)1.67614672
127Aplasia involving bones of the extremities (HP:0009825)1.67525875
128Aplasia involving bones of the upper limbs (HP:0009823)1.67525875
129Aplasia of the phalanges of the hand (HP:0009802)1.67525875
130Overgrowth (HP:0001548)1.67481401
131Split foot (HP:0001839)1.67034325
132Microglossia (HP:0000171)1.66986016
133Congenital glaucoma (HP:0001087)1.66681891

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PINK14.33877978
2DDR24.12476960
3EPHB24.11661953
4TRIB33.22314931
5TTN3.15475080
6NTRK13.15089715
7PRPF4B3.13676211
8DAPK23.11448784
9LATS13.09189391
10LATS22.93084879
11PDGFRA2.91283098
12PKN22.38636808
13TAOK22.30583114
14ERN12.27199040
15CDK122.10898339
16ICK2.02729530
17CLK12.00897708
18RIPK11.99547528
19BMX1.99475997
20NEK91.87915086
21SIK11.85211232
22MET1.79063958
23MAP3K101.71326886
24EPHA31.58166973
25PRKD21.54478229
26DAPK31.52498988
27PAK21.51411391
28SMG11.40304227
29FGFR41.35871270
30MARK21.24494310
31RPS6KA21.23535900
32PAK41.20802363
33PTK61.19925089
34MAPK151.19616695
35MST1R1.17832541
36MOS1.17171821
37NUAK11.15311548
38FGFR11.15296536
39EEF2K1.14102699
40MAP3K61.12615712
41TYRO31.10728973
42* MTOR1.08493456
43RPS6KA41.03170182
44PTK20.98742677
45STK30.95918640
46LRRK20.93609679
47DMPK0.91261220
48AKT30.91139665
49DAPK10.90809422
50MKNK10.90671356
51PDGFRB0.88905162
52CDK60.87267462
53LIMK10.85391601
54PRKD30.82223004
55STK38L0.81981088
56CAMK1D0.77284892
57DYRK1B0.77230245
58KIT0.75843341
59CDK70.75831955
60STK380.75503691
61ERBB30.73283601
62FER0.72511854
63TGFBR20.71121976
64TGFBR10.67481721
65MARK10.65947110
66PAK30.62668094
67INSR0.62440913
68EPHB10.62091493
69PAK60.61616647
70PASK0.60870980
71NEK20.60776895
72EPHA40.60733816
73EPHA20.60512020
74ERBB20.60232775
75GRK50.59092473
76BRD40.58546140
77FGFR20.58337724
78TIE10.56336548
79RPS6KB20.55720960
80ILK0.54219166
81ROCK10.54139250
82YES10.53909320
83CDK80.53327766
84PNCK0.53125806
85MAP3K80.50995494
86NTRK20.50498972
87CDC70.49753076
88TESK10.48192037
89CDK11A0.48060950
90PRKCH0.47559883
91HIPK20.47069353
92DYRK20.46969271
93MELK0.46286988
94AKT20.46207795
95TTK0.44545458
96CDK150.43018816
97CSNK1A1L0.42913132
98CAMK1G0.41499223
99RET0.41214675
100WNK10.41158352
101CDC42BPA0.40120258
102* RPS6KC10.38855403
103* RPS6KL10.38855403
104PTK2B0.37592431
105CDK40.36114000
106SRC0.35517852
107PAK10.34997570
108MKNK20.34864533
109* MAPK10.34504390
110PLK30.34492866
111FLT30.34196496
112MAP2K10.34001613
113CDK180.33773013
114ROCK20.33707061
115ADRBK10.33147168
116TRPM70.30919490
117AKT10.30811157
118PIK3CG0.30227145
119MAP2K20.29978893
120LMTK20.29123839
121CAMK2G0.28774284
122PLK20.28430419
123CDK90.28112524
124MAPK40.27788111
125UHMK10.27562014
126MYLK0.27443222
127ABL20.27366514
128CAMK40.26636496
129CAMK2B0.26533732
130PRKD10.26493434
131* RPS6KA60.26442342
132KSR10.26178668
133ERBB40.26137126
134PRKDC0.24772652
135* MAPK140.24119298
136SRPK10.24074118
137MAP3K70.23716665
138CAMK10.23314396
139GSK3A0.23015433
140CHUK0.22836411
141IGF1R0.22691718
142CSNK1E0.21385378

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052174.24206809
2Hedgehog signaling pathway_Homo sapiens_hsa043403.50948564
3ECM-receptor interaction_Homo sapiens_hsa045123.32949328
4One carbon pool by folate_Homo sapiens_hsa006703.01127415
5Hippo signaling pathway_Homo sapiens_hsa043902.79581862
6Focal adhesion_Homo sapiens_hsa045102.74599826
7Proteoglycans in cancer_Homo sapiens_hsa052052.54233317
8Adherens junction_Homo sapiens_hsa045202.46530357
9Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.31769055
10TGF-beta signaling pathway_Homo sapiens_hsa043502.29194633
11Protein digestion and absorption_Homo sapiens_hsa049742.17736753
12MicroRNAs in cancer_Homo sapiens_hsa052061.95236952
13Melanoma_Homo sapiens_hsa052181.87141444
14Amoebiasis_Homo sapiens_hsa051461.84027953
15* Wnt signaling pathway_Homo sapiens_hsa043101.83412094
16Small cell lung cancer_Homo sapiens_hsa052221.74710779
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.74430263
18* HTLV-I infection_Homo sapiens_hsa051661.65778638
19Melanogenesis_Homo sapiens_hsa049161.64210980
20* Axon guidance_Homo sapiens_hsa043601.63631160
21Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.52824517
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.51924662
23Malaria_Homo sapiens_hsa051441.51733291
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.51531941
25Pathways in cancer_Homo sapiens_hsa052001.50705563
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.47988754
27Bladder cancer_Homo sapiens_hsa052191.46620217
28PI3K-Akt signaling pathway_Homo sapiens_hsa041511.46371892
29Chronic myeloid leukemia_Homo sapiens_hsa052201.43214351
30Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.42346267
31Rap1 signaling pathway_Homo sapiens_hsa040151.36546505
32Notch signaling pathway_Homo sapiens_hsa043301.32256608
33Prostate cancer_Homo sapiens_hsa052151.31847708
34Dilated cardiomyopathy_Homo sapiens_hsa054141.29444712
35Colorectal cancer_Homo sapiens_hsa052101.28065869
36Platelet activation_Homo sapiens_hsa046111.24734774
37Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.24542940
38Tight junction_Homo sapiens_hsa045301.22207365
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.18927252
40Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.13953152
41Regulation of actin cytoskeleton_Homo sapiens_hsa048101.08950181
42Other glycan degradation_Homo sapiens_hsa005111.08885343
43p53 signaling pathway_Homo sapiens_hsa041151.05636916
44Vascular smooth muscle contraction_Homo sapiens_hsa042701.05520926
45Endometrial cancer_Homo sapiens_hsa052131.02222478
46Lysine degradation_Homo sapiens_hsa003100.97518762
47TNF signaling pathway_Homo sapiens_hsa046680.96005375
48Ribosome_Homo sapiens_hsa030100.95974605
49Cell cycle_Homo sapiens_hsa041100.92728644
50Leukocyte transendothelial migration_Homo sapiens_hsa046700.89906167
51Pancreatic cancer_Homo sapiens_hsa052120.89716909
52Cocaine addiction_Homo sapiens_hsa050300.88403869
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.86720750
54Leishmaniasis_Homo sapiens_hsa051400.85361270
55Sulfur relay system_Homo sapiens_hsa041220.85255556
56Glioma_Homo sapiens_hsa052140.84001165
57Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83361595
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80515169
59GnRH signaling pathway_Homo sapiens_hsa049120.78695263
60Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77495817
61Viral carcinogenesis_Homo sapiens_hsa052030.77048293
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77040598
63Viral myocarditis_Homo sapiens_hsa054160.72056935
64AMPK signaling pathway_Homo sapiens_hsa041520.71898503
65Renal cell carcinoma_Homo sapiens_hsa052110.71337997
66* Hepatitis B_Homo sapiens_hsa051610.67009139
67Adipocytokine signaling pathway_Homo sapiens_hsa049200.66646113
68Thyroid hormone synthesis_Homo sapiens_hsa049180.66518636
69Shigellosis_Homo sapiens_hsa051310.65314065
70Spliceosome_Homo sapiens_hsa030400.64721125
71HIF-1 signaling pathway_Homo sapiens_hsa040660.64640533
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64638654
73Choline metabolism in cancer_Homo sapiens_hsa052310.64608778
74cAMP signaling pathway_Homo sapiens_hsa040240.64230100
75Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.63841974
76Toxoplasmosis_Homo sapiens_hsa051450.63433464
77Thyroid cancer_Homo sapiens_hsa052160.62599949
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62204071
79Insulin resistance_Homo sapiens_hsa049310.61722275
80mTOR signaling pathway_Homo sapiens_hsa041500.61024507
81Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.60031598
82Prion diseases_Homo sapiens_hsa050200.56849783
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55020830
84Estrogen signaling pathway_Homo sapiens_hsa049150.54244145
85Cholinergic synapse_Homo sapiens_hsa047250.53856842
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.53302504
87Gap junction_Homo sapiens_hsa045400.51256469
88Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51065868
89Neurotrophin signaling pathway_Homo sapiens_hsa047220.50972886
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50797159
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49756987
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.49649505
93Ras signaling pathway_Homo sapiens_hsa040140.49484729
94Non-homologous end-joining_Homo sapiens_hsa034500.49463200
95FoxO signaling pathway_Homo sapiens_hsa040680.48288934
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.47850371
97Insulin secretion_Homo sapiens_hsa049110.47610017
98Alcoholism_Homo sapiens_hsa050340.46440276
99* cGMP-PKG signaling pathway_Homo sapiens_hsa040220.45903548
100Type II diabetes mellitus_Homo sapiens_hsa049300.45324343
101Gastric acid secretion_Homo sapiens_hsa049710.43482568
102* Oxytocin signaling pathway_Homo sapiens_hsa049210.43412414
103MAPK signaling pathway_Homo sapiens_hsa040100.43306140
104Salmonella infection_Homo sapiens_hsa051320.42840533
105Calcium signaling pathway_Homo sapiens_hsa040200.42619866
106Prolactin signaling pathway_Homo sapiens_hsa049170.42185902
107Dorso-ventral axis formation_Homo sapiens_hsa043200.41182831
108Apoptosis_Homo sapiens_hsa042100.41072907
109Systemic lupus erythematosus_Homo sapiens_hsa053220.40817602
110Galactose metabolism_Homo sapiens_hsa000520.38823632
111VEGF signaling pathway_Homo sapiens_hsa043700.38596168
112Ovarian steroidogenesis_Homo sapiens_hsa049130.38422022
113mRNA surveillance pathway_Homo sapiens_hsa030150.37593285
114Insulin signaling pathway_Homo sapiens_hsa049100.36495529
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36308966
116Circadian entrainment_Homo sapiens_hsa047130.36013848
117Phospholipase D signaling pathway_Homo sapiens_hsa040720.35606063
118Glutamatergic synapse_Homo sapiens_hsa047240.34441607
119Phagosome_Homo sapiens_hsa041450.34205771
120Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.34061038
121Non-small cell lung cancer_Homo sapiens_hsa052230.33734672
122RNA transport_Homo sapiens_hsa030130.32934138
123ErbB signaling pathway_Homo sapiens_hsa040120.32211191
124Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31370992
125N-Glycan biosynthesis_Homo sapiens_hsa005100.30376498
126Endocytosis_Homo sapiens_hsa041440.29854469
127Cardiac muscle contraction_Homo sapiens_hsa042600.29772062
128Glucagon signaling pathway_Homo sapiens_hsa049220.28631141
129Renin secretion_Homo sapiens_hsa049240.28574394
130Inositol phosphate metabolism_Homo sapiens_hsa005620.25096039

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