NFE2L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is involved in globin gene expression in erythrocytes. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene, NFE2L1, and for 'nuclear respiratory factor 1' which has an official symbol of NRF1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane repair (GO:0001778)5.22927668
2negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.65465600
3negative regulation of potassium ion transmembrane transport (GO:1901380)4.28162478
4desmosome organization (GO:0002934)3.70318603
5sarcomere organization (GO:0045214)3.55895349
6cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.55614808
7carnitine shuttle (GO:0006853)3.53538246
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.44585408
9NADH metabolic process (GO:0006734)3.40013788
10planar cell polarity pathway involved in neural tube closure (GO:0090179)3.38118677
11COPI coating of Golgi vesicle (GO:0048205)3.37829461
12Golgi transport vesicle coating (GO:0048200)3.37829461
13cardiac myofibril assembly (GO:0055003)3.36318827
14skin morphogenesis (GO:0043589)3.33537261
15negative regulation of cell size (GO:0045792)3.27201150
16muscle filament sliding (GO:0030049)3.26677108
17actin-myosin filament sliding (GO:0033275)3.26677108
18fatty acid transmembrane transport (GO:1902001)3.25484710
19cytoskeletal anchoring at plasma membrane (GO:0007016)3.24620301
20cell communication involved in cardiac conduction (GO:0086065)3.17885800
21maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.16947207
22cell communication by electrical coupling (GO:0010644)3.13679760
23regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.10321642
24myofibril assembly (GO:0030239)3.09061802
25protein retention in ER lumen (GO:0006621)3.05013944
26basement membrane organization (GO:0071711)3.04419811
27proline transport (GO:0015824)3.04024263
28skeletal muscle contraction (GO:0003009)2.99505790
29regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.98181095
30response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.98016100
31sodium ion export (GO:0071436)2.97543463
32regulation of early endosome to late endosome transport (GO:2000641)2.95438104
33synaptic vesicle maturation (GO:0016188)2.95376317
34regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.92325745
35regulation of skeletal muscle contraction (GO:0014819)2.91904461
36regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.90469258
37endodermal cell differentiation (GO:0035987)2.89851868
38barbed-end actin filament capping (GO:0051016)2.89762216
39cell adhesion mediated by integrin (GO:0033627)2.88998625
40cardiac muscle contraction (GO:0060048)2.88318188
41activation of protein kinase A activity (GO:0034199)2.88163909
42regulation of p38MAPK cascade (GO:1900744)2.87969668
43regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.85895403
44sarcoplasmic reticulum calcium ion transport (GO:0070296)2.85272080
45apoptotic cell clearance (GO:0043277)2.79587115
46dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.76092314
47retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.75258128
48positive regulation of histone deacetylation (GO:0031065)2.74167166
49protein localization to endosome (GO:0036010)2.72309758
50semaphorin-plexin signaling pathway (GO:0071526)2.70360881
51stress fiber assembly (GO:0043149)2.70260832
52actin-mediated cell contraction (GO:0070252)2.68709501
53ventricular cardiac muscle cell action potential (GO:0086005)2.67358183
54regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.66068846
55actomyosin structure organization (GO:0031032)2.64689527
56regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.64166140
57adherens junction assembly (GO:0034333)2.63812261
58surfactant homeostasis (GO:0043129)2.63554154
59regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.62265525
60positive regulation of fatty acid beta-oxidation (GO:0032000)2.60467427
61tricarboxylic acid cycle (GO:0006099)2.59586870
62creatine metabolic process (GO:0006600)2.59496247
63low-density lipoprotein particle clearance (GO:0034383)2.59413574
64carnitine transmembrane transport (GO:1902603)2.57359857
65regulation of fatty acid oxidation (GO:0046320)2.56970293
66regulation of glucose import in response to insulin stimulus (GO:2001273)2.56908316
67cell-substrate junction assembly (GO:0007044)2.56477146
68regulation of cholesterol homeostasis (GO:2000188)2.55308203
69striated muscle contraction (GO:0006941)2.54651508
70regulation of the force of heart contraction (GO:0002026)2.54302536
71negative regulation of potassium ion transport (GO:0043267)2.53017629
72bundle of His cell to Purkinje myocyte communication (GO:0086069)2.52509479
73positive regulation of p38MAPK cascade (GO:1900745)2.50278241
74endothelial cell chemotaxis (GO:0035767)2.49641473
75focal adhesion assembly (GO:0048041)2.49388228
76cell-substrate adherens junction assembly (GO:0007045)2.49388228
77regulation of fatty acid beta-oxidation (GO:0031998)2.48694267
78peptidyl-proline hydroxylation (GO:0019511)2.48578554
79epithelial cell-cell adhesion (GO:0090136)2.47727316
80regulation of membrane repolarization (GO:0060306)2.44626386
81regulation of sequestering of triglyceride (GO:0010889)2.42299251
822-oxoglutarate metabolic process (GO:0006103)2.40743832
83positive regulation of fatty acid oxidation (GO:0046321)2.39605455
84insulin-like growth factor receptor signaling pathway (GO:0048009)2.39597474
85actin filament-based movement (GO:0030048)2.39502383
86response to muscle activity (GO:0014850)2.39281838
87amino-acid betaine transport (GO:0015838)2.38609816
88carnitine transport (GO:0015879)2.38609816
89growth hormone secretion (GO:0030252)2.38037422
90vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.37896596
91positive regulation of receptor recycling (GO:0001921)2.37226390
92potassium ion import (GO:0010107)2.36831612
93regulation of NFAT protein import into nucleus (GO:0051532)2.36627127
94positive regulation of glycogen biosynthetic process (GO:0045725)2.36516172
95regulation of tight junction assembly (GO:2000810)2.36270422
96hemidesmosome assembly (GO:0031581)2.36160651
97cardiac muscle cell development (GO:0055013)2.36102684
984-hydroxyproline metabolic process (GO:0019471)2.35694554
99paraxial mesoderm development (GO:0048339)2.33290053
100gap junction assembly (GO:0016264)2.32460516
101vascular endothelial growth factor signaling pathway (GO:0038084)2.31705984
102positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.30368273
103neuromuscular junction development (GO:0007528)2.27961294
104cardiac muscle cell proliferation (GO:0060038)2.27876214
105atrioventricular valve morphogenesis (GO:0003181)2.23856863
106Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.23700437
107positive regulation of myotube differentiation (GO:0010831)2.23623742
108regulation of calcium ion transmembrane transport (GO:1903169)2.23548156
109regulation of calcium ion transmembrane transporter activity (GO:1901019)2.23548156
110cardiac cell development (GO:0055006)2.22391097
111regulation of synapse structural plasticity (GO:0051823)2.22336142
112negative regulation of fatty acid transport (GO:2000192)2.22125279
113NLS-bearing protein import into nucleus (GO:0006607)2.22014476
114positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.21830544
115macroautophagy (GO:0016236)2.21611758
116negative regulation of chondrocyte differentiation (GO:0032331)2.21597977
117skeletal muscle adaptation (GO:0043501)2.21533030
118regulation of extracellular matrix disassembly (GO:0010715)2.20637053
119myoblast fusion (GO:0007520)2.20058032
120layer formation in cerebral cortex (GO:0021819)2.19886481
121activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.19688132
122adherens junction organization (GO:0034332)2.19109278
123protein heterotrimerization (GO:0070208)2.18964739
124negative regulation of cardiac muscle tissue growth (GO:0055022)2.18344021
125negative regulation of heart growth (GO:0061117)2.18344021
126alanine transport (GO:0032328)2.18036576
127chemical homeostasis within a tissue (GO:0048875)2.17562935
128endothelial cell morphogenesis (GO:0001886)2.17554944
129locomotory exploration behavior (GO:0035641)2.17424921
130apoptotic process involved in morphogenesis (GO:0060561)2.17276753
131intracellular lipid transport (GO:0032365)2.17248609
132positive regulation of blood vessel endothelial cell migration (GO:0043536)2.17114752
133regulation of hippo signaling (GO:0035330)2.16663400
134positive regulation of macrophage cytokine production (GO:0060907)2.16511387
135protein hydroxylation (GO:0018126)2.16496006
136cellular potassium ion homeostasis (GO:0030007)2.16483378
137regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.16445909
138protein targeting to plasma membrane (GO:0072661)2.15883095
139negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.15786431
140biotin metabolic process (GO:0006768)2.15767651
141muscle contraction (GO:0006936)2.15553368
142cell volume homeostasis (GO:0006884)2.15216050
143regulation of actin filament-based movement (GO:1903115)2.15095657
144cardiac muscle hypertrophy (GO:0003300)2.14511081
145syncytium formation by plasma membrane fusion (GO:0000768)2.13973785
146glycogen catabolic process (GO:0005980)2.13803992
147maternal placenta development (GO:0001893)2.13486468
148pyrimidine ribonucleoside catabolic process (GO:0046133)2.13467825
149membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.13251249
150actin filament depolymerization (GO:0030042)2.12967247
151positive regulation of axon extension (GO:0045773)2.12885074
152positive regulation of nuclease activity (GO:0032075)2.12003321
153regulation of establishment of planar polarity (GO:0090175)2.11755209
154retina vasculature morphogenesis in camera-type eye (GO:0061299)2.11652043
155cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.11417670
156striated muscle hypertrophy (GO:0014897)2.10175522

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.56942150
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.76302925
3RARG_19884340_ChIP-ChIP_MEFs_Mouse2.28604976
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.26833033
5ESR2_21235772_ChIP-Seq_MCF-7_Human2.24740745
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.04418428
7CLOCK_20551151_ChIP-Seq_293T_Human2.01198852
8ZNF263_19887448_ChIP-Seq_K562_Human2.01179349
9EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.99919190
10PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.99851993
11SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.99181257
12TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.98684147
13ZFP281_18757296_ChIP-ChIP_E14_Mouse1.96838233
14KDM2B_26808549_Chip-Seq_K562_Human1.91652358
15KDM2B_26808549_Chip-Seq_SUP-B15_Human1.91362266
16WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.86393862
17ESR1_20079471_ChIP-ChIP_T-47D_Human1.82630444
18* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78580901
19TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.68510062
20LXR_22292898_ChIP-Seq_THP-1_Human1.64251360
21* NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.62799878
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.61962073
23TBX20_22080862_ChIP-Seq_HEART_Mouse1.61051214
24TBX20_22328084_ChIP-Seq_HEART_Mouse1.61051214
25ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.60615413
26STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60107464
27EP300_21415370_ChIP-Seq_HL-1_Mouse1.56512925
28KDM2B_26808549_Chip-Seq_DND41_Human1.54277173
29ESR1_21235772_ChIP-Seq_MCF-7_Human1.52754807
30RACK7_27058665_Chip-Seq_MCF-7_Human1.50114239
31ZFP281_27345836_Chip-Seq_ESCs_Mouse1.49152320
32* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.48467441
33ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.44908360
34P300_27058665_Chip-Seq_ZR-75-30cells_Human1.44568650
35MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44498345
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.43811487
37* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43791505
38FOXO3_23340844_ChIP-Seq_DLD1_Human1.41944355
39* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.40933410
40RNF2_18974828_ChIP-Seq_MESCs_Mouse1.40151502
41EZH2_18974828_ChIP-Seq_MESCs_Mouse1.40151502
42DROSHA_22980978_ChIP-Seq_HELA_Human1.39618138
43NFIB_24661679_ChIP-Seq_LUNG_Mouse1.38833080
44RARB_27405468_Chip-Seq_BRAIN_Mouse1.37864037
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.37551520
46ELK3_25401928_ChIP-Seq_HUVEC_Human1.35779520
47TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.34616863
48HIF1A_21447827_ChIP-Seq_MCF-7_Human1.34363799
49* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.34178248
50* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33937361
51SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.31108758
52LXR_22158963_ChIP-Seq_LIVER_Mouse1.30552074
53CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.30292897
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29369363
55* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.27407820
56* ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.26492102
57KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26138422
58TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.25198669
59SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.24767450
60* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24102825
61* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.24059013
62MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23611480
63STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.23222750
64CREB1_26743006_Chip-Seq_LNCaP_Human1.21908077
65PPARA_22158963_ChIP-Seq_LIVER_Mouse1.21711930
66* RXR_22158963_ChIP-Seq_LIVER_Mouse1.21272646
67SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21088931
68BP1_19119308_ChIP-ChIP_Hs578T_Human1.20937012
69* UBF1/2_26484160_Chip-Seq_HMECs_Human1.20915609
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20872354
71KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.20272060
72ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.20105249
73SOX2_27498859_Chip-Seq_STOMACH_Mouse1.19582516
74ATF3_27146783_Chip-Seq_COLON_Human1.18733250
75PPAR_26484153_Chip-Seq_NCI-H1993_Human1.18122160
76* RUNX1_27514584_Chip-Seq_MCF-7_Human1.16682324
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.16425831
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15165648
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.14477608
80SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14477564
81KDM2B_26808549_Chip-Seq_JURKAT_Human1.14362424
82NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.13182468
83NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.11739818
84FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.11278172
85SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.11034838
86* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10017708
87SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.08718978
88NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.07917542
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07791858
90* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07363942
91MYC_22102868_ChIP-Seq_BL_Human1.07243098
92P63_26484246_Chip-Seq_KERATINOCYTES_Human1.07141556
93* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.07122784
94* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.07122784
95SOX9_24532713_ChIP-Seq_HFSC_Mouse1.06961142
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06272650
97CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06243220
98* TCF7_22412390_ChIP-Seq_EML_Mouse1.05116729
99* TET1_21490601_ChIP-Seq_MESCs_Mouse1.04971113
100* SMC4_20622854_ChIP-Seq_HELA_Human1.04868336
101* FOXA2_19822575_ChIP-Seq_HepG2_Human1.04698753
102JARID2_20075857_ChIP-Seq_MESCs_Mouse1.02762743
103KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01804319
104* AHR_22903824_ChIP-Seq_MCF-7_Human1.01257969
105CTCF_27219007_Chip-Seq_ERYTHROID_Human1.01010166
106KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00703713
107EGR1_19374776_ChIP-ChIP_THP-1_Human1.00426366
108TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.00211174
109KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99935126
110KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99935126
111KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99935126
112TP53_23651856_ChIP-Seq_MEFs_Mouse0.99725575
113SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99577616
114* TP63_22573176_ChIP-Seq_HFKS_Human0.99169599
115WT1_19549856_ChIP-ChIP_CCG9911_Human0.98744324
116EZH2_22144423_ChIP-Seq_EOC_Human0.98560312
117GATA2_21666600_ChIP-Seq_HMVEC_Human0.98454727
118SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.98024932
119SMC1_22415368_ChIP-Seq_MEFs_Mouse0.97212189
120FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.97165898
121ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97152194
122SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96516123
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95637568
124CTCF_27219007_Chip-Seq_Bcells_Human0.95182146
125TP53_22127205_ChIP-Seq_IMR90_Human0.94929880
126ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.94383666
127TP53_20018659_ChIP-ChIP_R1E_Mouse0.94087695
128GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.93896289
129VDR_21846776_ChIP-Seq_THP-1_Human0.93750187
130RNF2_27304074_Chip-Seq_ESCs_Mouse0.92807936
131ESR1_15608294_ChIP-ChIP_MCF-7_Human0.92631026

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis3.84129918
2MP0000751_myopathy3.68207471
3MP0003705_abnormal_hypodermis_morpholog3.59915049
4MP0004084_abnormal_cardiac_muscle3.06854753
5MP0000749_muscle_degeneration2.71097177
6MP0004130_abnormal_muscle_cell2.65739555
7MP0003646_muscle_fatigue2.59803970
8MP0004858_abnormal_nervous_system2.58566967
9MP0004036_abnormal_muscle_relaxation2.44440169
10MP0004087_abnormal_muscle_fiber2.43425577
11MP0005451_abnormal_body_composition2.41671088
12MP0008438_abnormal_cutaneous_collagen2.38776550
13MP0005409_darkened_coat_color2.21146004
14MP0000750_abnormal_muscle_regeneration2.18018224
15MP0005275_abnormal_skin_tensile2.15231553
16MP0008961_abnormal_basal_metabolism2.13105450
17MP0004145_abnormal_muscle_electrophysio2.11801371
18MP0002909_abnormal_adrenal_gland2.10437557
19MP0002269_muscular_atrophy2.10191466
20MP0005623_abnormal_meninges_morphology2.08465721
21MP0005330_cardiomyopathy2.08090340
22MP0004185_abnormal_adipocyte_glucose2.06219381
23MP0004215_abnormal_myocardial_fiber2.03367102
24MP0000747_muscle_weakness2.02276662
25MP0000579_abnormal_nail_morphology1.99770945
26MP0005666_abnormal_adipose_tissue1.96287268
27MP0003283_abnormal_digestive_organ1.93170758
28MP0005670_abnormal_white_adipose1.92364042
29MP0009780_abnormal_chondrocyte_physiolo1.88703333
30MP0000759_abnormal_skeletal_muscle1.86725180
31MP0000013_abnormal_adipose_tissue1.84273479
32MP0004859_abnormal_synaptic_plasticity1.84063783
33MP0005620_abnormal_muscle_contractility1.81539770
34MP0004272_abnormal_basement_membrane1.76085968
35MP0003566_abnormal_cell_adhesion1.74990740
36MP0002106_abnormal_muscle_physiology1.74960983
37MP0002254_reproductive_system_inflammat1.73856110
38MP0003941_abnormal_skin_development1.67744262
39MP0005375_adipose_tissue_phenotype1.67529188
40MP0002972_abnormal_cardiac_muscle1.67038055
41MP0010234_abnormal_vibrissa_follicle1.66888279
42MP0008775_abnormal_heart_ventricle1.63008162
43MP0010630_abnormal_cardiac_muscle1.62408608
44MP0004233_abnormal_muscle_weight1.58611100
45MP0003045_fibrosis1.58203306
46MP0002877_abnormal_melanocyte_morpholog1.53431591
47MP0005369_muscle_phenotype1.52643518
48MP0006138_congestive_heart_failure1.49509988
49MP0000003_abnormal_adipose_tissue1.48795595
50MP0000762_abnormal_tongue_morphology1.44806258
51MP0002060_abnormal_skin_morphology1.42067346
52MP0003137_abnormal_impulse_conducting1.42051610
53MP0002332_abnormal_exercise_endurance1.38716122
54MP0001544_abnormal_cardiovascular_syste1.38396799
55MP0005385_cardiovascular_system_phenoty1.38396799
56MP0009840_abnormal_foam_cell1.37469179
57MP0010352_gastrointestinal_tract_polyps1.34497374
58MP0005058_abnormal_lysosome_morphology1.32463309
59MP0003453_abnormal_keratinocyte_physiol1.30733713
60MP0000733_abnormal_muscle_development1.28239991
61MP0002108_abnormal_muscle_morphology1.24389178
62MP0004270_analgesia1.24109784
63MP0004484_altered_response_of1.22543398
64MP0004085_abnormal_heartbeat1.17357192
65MP0010030_abnormal_orbit_morphology1.16105117
66MP0000467_abnormal_esophagus_morphology1.14850552
67MP0000537_abnormal_urethra_morphology1.14174796
68MP0001849_ear_inflammation1.12791507
69MP0003279_aneurysm1.12003971
70MP0009384_cardiac_valve_regurgitation1.10698239
71MP0003950_abnormal_plasma_membrane1.10155435
72MP0003300_gastrointestinal_ulcer1.09708716
73MP0002089_abnormal_postnatal_growth/wei1.09654408
74MP0001348_abnormal_lacrimal_gland1.09358420
75MP0000678_abnormal_parathyroid_gland1.09096428
76MP0005076_abnormal_cell_differentiation1.08421443
77MP0005167_abnormal_blood-brain_barrier1.05908299
78MP0003091_abnormal_cell_migration1.05737622
79MP0000566_synostosis1.04331817
80MP0004510_myositis1.03834336
81MP0004043_abnormal_pH_regulation1.03818457
82MP0002234_abnormal_pharynx_morphology1.01083468
83MP0002971_abnormal_brown_adipose0.98782770
84MP0003221_abnormal_cardiomyocyte_apopto0.96389080
85MP0010368_abnormal_lymphatic_system0.93309259
86MP0001661_extended_life_span0.92956204
87MP0003329_amyloid_beta_deposits0.91569449
88MP0002896_abnormal_bone_mineralization0.90129561
89MP0003828_pulmonary_edema0.89662078
90MP0001958_emphysema0.87242967
91MP0001299_abnormal_eye_distance/0.86712301
92MP0009672_abnormal_birth_weight0.86063408
93MP0001915_intracranial_hemorrhage0.84409567
94MP0004264_abnormal_extraembryonic_tissu0.83471572
95MP0008260_abnormal_autophagy0.83290299
96MP0002796_impaired_skin_barrier0.80940349
97MP0000462_abnormal_digestive_system0.80448934
98MP0000266_abnormal_heart_morphology0.79932205
99MP0005508_abnormal_skeleton_morphology0.79740305
100MP0003634_abnormal_glial_cell0.76001187
101MP0003385_abnormal_body_wall0.74955396
102MP0002078_abnormal_glucose_homeostasis0.74396457
103MP0005501_abnormal_skin_physiology0.73429226
104MP0009053_abnormal_anal_canal0.72255645
105MP0009115_abnormal_fat_cell0.71831944
106MP0002249_abnormal_larynx_morphology0.71263126
107MP0005023_abnormal_wound_healing0.69959142
108MP0000534_abnormal_ureter_morphology0.69463281
109MP0003075_altered_response_to0.67532206
110MP0002970_abnormal_white_adipose0.66680524
111MP0005503_abnormal_tendon_morphology0.66641542
112MP0003115_abnormal_respiratory_system0.66372149
113MP0002127_abnormal_cardiovascular_syste0.65944036
114MP0003635_abnormal_synaptic_transmissio0.65645620
115MP0001614_abnormal_blood_vessel0.65497460
116MP0002295_abnormal_pulmonary_circulatio0.64965078
117MP0005257_abnormal_intraocular_pressure0.64785398
118MP0002168_other_aberrant_phenotype0.62951219
119MP0002925_abnormal_cardiovascular_devel0.62686263
120MP0002128_abnormal_blood_circulation0.61316978
121MP0010329_abnormal_lipoprotein_level0.61315579
122MP0005535_abnormal_body_temperature0.61114656
123MP0000343_altered_response_to0.59263956
124MP0002118_abnormal_lipid_homeostasis0.59009080
125MP0005334_abnormal_fat_pad0.58504498
126MP0000767_abnormal_smooth_muscle0.58447984
127MP0005165_increased_susceptibility_to0.56199916
128MP0003191_abnormal_cellular_cholesterol0.55426870
129MP0003252_abnormal_bile_duct0.54255552
130MP0003122_maternal_imprinting0.53868180

Predicted human phenotypes

RankGene SetZ-score
1Difficulty running (HP:0009046)4.41812808
2Increased connective tissue (HP:0009025)4.31317464
3Hyporeflexia of lower limbs (HP:0002600)4.21433704
4Exercise-induced muscle cramps (HP:0003710)4.18001980
5Exercise-induced myalgia (HP:0003738)4.14735016
6Sudden death (HP:0001699)3.84811096
7Type 1 muscle fiber predominance (HP:0003803)3.82919523
8Muscle fiber splitting (HP:0003555)3.72534471
9Myoglobinuria (HP:0002913)3.40197148
10Increased variability in muscle fiber diameter (HP:0003557)3.38997448
11Right ventricular cardiomyopathy (HP:0011663)3.38765274
12Centrally nucleated skeletal muscle fibers (HP:0003687)3.31703937
13Difficulty climbing stairs (HP:0003551)3.21937244
14Ventricular tachycardia (HP:0004756)3.18105813
15Abnormality of skeletal muscle fiber size (HP:0012084)3.10918223
16Mildly elevated creatine phosphokinase (HP:0008180)3.10275156
17Calf muscle hypertrophy (HP:0008981)3.09934588
18EMG: myopathic abnormalities (HP:0003458)3.00102429
19Cerebral aneurysm (HP:0004944)2.96752546
20Bundle branch block (HP:0011710)2.90687310
21Distal upper limb amyotrophy (HP:0007149)2.90685099
22Upper limb amyotrophy (HP:0009129)2.90685099
23Abnormality of the calf musculature (HP:0001430)2.89537155
24Muscle hypertrophy of the lower extremities (HP:0008968)2.88946851
25Abnormality of the lower motor neuron (HP:0002366)2.85005696
26Muscle fiber inclusion bodies (HP:0100299)2.83443166
27Myotonia (HP:0002486)2.76658883
28Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.74828287
29Arterial tortuosity (HP:0005116)2.73819871
30Protrusio acetabuli (HP:0003179)2.72422811
31Vascular tortuosity (HP:0004948)2.70203957
32Asymmetric septal hypertrophy (HP:0001670)2.64036368
33Achilles tendon contracture (HP:0001771)2.63048554
34Broad metatarsal (HP:0001783)2.56739876
35EMG: neuropathic changes (HP:0003445)2.54298566
36Fragile skin (HP:0001030)2.52608336
37Hand muscle atrophy (HP:0009130)2.48490820
38Round ear (HP:0100830)2.45707551
39Abnormality of the Achilles tendon (HP:0005109)2.45329723
40Atrial fibrillation (HP:0005110)2.41483797
41Primary atrial arrhythmia (HP:0001692)2.34918425
42Lymphangioma (HP:0100764)2.34548060
43Ventricular fibrillation (HP:0001663)2.34150989
44Abnormality of the left ventricular outflow tract (HP:0011103)2.34057637
45Subaortic stenosis (HP:0001682)2.34057637
46Distal arthrogryposis (HP:0005684)2.32208846
47Vertebral compression fractures (HP:0002953)2.31922699
48Scapular winging (HP:0003691)2.31119554
49Muscle stiffness (HP:0003552)2.29498406
50Frequent falls (HP:0002359)2.28815355
51Ventricular arrhythmia (HP:0004308)2.28741782
52Atrioventricular block (HP:0001678)2.28211919
53Premature rupture of membranes (HP:0001788)2.27714823
54Aneurysm (HP:0002617)2.25789067
55Calcaneovalgus deformity (HP:0001848)2.20276310
56Abnormal atrioventricular conduction (HP:0005150)2.19903640
57Supraventricular arrhythmia (HP:0005115)2.19466010
58Resting tremor (HP:0002322)2.17585692
59Heart block (HP:0012722)2.17459440
60Testicular atrophy (HP:0000029)2.16879819
61Supraventricular tachycardia (HP:0004755)2.16028209
62Back pain (HP:0003418)2.15624624
63Nemaline bodies (HP:0003798)2.15348694
64Ankle contracture (HP:0006466)2.15331367
65Ulnar bowing (HP:0003031)2.14522742
66Rapidly progressive (HP:0003678)2.13924750
67Distal lower limb amyotrophy (HP:0008944)2.12375729
68Myopathic facies (HP:0002058)2.11479214
69Aortic dissection (HP:0002647)2.10804236
70Spinal rigidity (HP:0003306)2.08238153
71Shallow orbits (HP:0000586)2.06479937
72Dysmetric saccades (HP:0000641)2.06457765
73Lipoatrophy (HP:0100578)2.06106468
74Lower limb amyotrophy (HP:0007210)2.05638119
75Hamartoma of the eye (HP:0010568)2.04588646
76Wormian bones (HP:0002645)2.04188072
77Hypoplastic ischia (HP:0003175)2.02573476
78Syncope (HP:0001279)2.02086720
79Abnormality of the calcaneus (HP:0008364)2.01597626
80Ketoacidosis (HP:0001993)2.01420917
81Hyperinsulinemic hypoglycemia (HP:0000825)2.00122158
82Cerebral inclusion bodies (HP:0100314)1.98476119
83Pterygium (HP:0001059)1.98468886
84Flat acetabular roof (HP:0003180)1.97319329
85Limb-girdle muscle atrophy (HP:0003797)1.95653701
86Foot dorsiflexor weakness (HP:0009027)1.94656976
87Deep venous thrombosis (HP:0002625)1.94189038
88Advanced eruption of teeth (HP:0006288)1.93546082
89Neurofibrillary tangles (HP:0002185)1.93458260
90Obstructive sleep apnea (HP:0002870)1.93231054
91Prolonged QT interval (HP:0001657)1.92808947
92Cervical subluxation (HP:0003308)1.92741746
93Neonatal short-limb short stature (HP:0008921)1.90588504
94Skin nodule (HP:0200036)1.90331585
95Ulnar deviation of the wrist (HP:0003049)1.89293380
96Hypercortisolism (HP:0001578)1.88996384
97Rhabdomyolysis (HP:0003201)1.88406589
98Deformed tarsal bones (HP:0008119)1.87633940
99Abnormality of the foot musculature (HP:0001436)1.87189581
100Mitral valve prolapse (HP:0001634)1.86997464
101Slender build (HP:0001533)1.85660719
102Abnormality of the ischium (HP:0003174)1.81780351
103Mitral regurgitation (HP:0001653)1.81011728
104Vertebral arch anomaly (HP:0008438)1.79738178
105Broad face (HP:0000283)1.79233599
106Proximal amyotrophy (HP:0007126)1.78990109
107Facial diplegia (HP:0001349)1.78223071
108Distal lower limb muscle weakness (HP:0009053)1.77555727
109Neoplasm of the heart (HP:0100544)1.76444296
110Blue sclerae (HP:0000592)1.75661244
111Bulbar palsy (HP:0001283)1.73395210
112Natal tooth (HP:0000695)1.69451194
113Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.68756352
114Atrophic scars (HP:0001075)1.68463019
115Long toe (HP:0010511)1.67512337
116Dilated cardiomyopathy (HP:0001644)1.67277942
117Breech presentation (HP:0001623)1.66975691
118Macroorchidism (HP:0000053)1.66961308
119Enlarged penis (HP:0000040)1.66929125
120Neck muscle weakness (HP:0000467)1.66770290
121Asymmetry of the thorax (HP:0001555)1.66761026
122Insomnia (HP:0100785)1.66514284
123Osteolytic defects of the phalanges of the hand (HP:0009771)1.66457275
124Osteolytic defects of the hand bones (HP:0009699)1.66457275
125Bladder diverticulum (HP:0000015)1.66013947
126Generalized amyotrophy (HP:0003700)1.65613395
127Multiple enchondromatosis (HP:0005701)1.65225073
128Turricephaly (HP:0000262)1.64845951
129Milia (HP:0001056)1.62263757
130Palpitations (HP:0001962)1.61273147
131Hyperextensible skin (HP:0000974)1.60938019
132Hip contracture (HP:0003273)1.60842661
133Abnormal EKG (HP:0003115)1.59282268
134Generalized muscle weakness (HP:0003324)1.58519282
135Limb-girdle muscle weakness (HP:0003325)1.56576635
136Aortic aneurysm (HP:0004942)1.55866660
137Hyperacusis (HP:0010780)1.53606262
138Peritonitis (HP:0002586)1.52736530

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.09697394
2TTN3.32873690
3ERN12.68924025
4PKN22.52775657
5RIPK12.42564633
6CDK122.22802677
7PHKG12.14326212
8PHKG22.14326212
9SMG12.14102307
10PDGFRA2.08607960
11LMTK22.03600824
12PRPF4B1.98248968
13MAP3K91.91588754
14NTRK11.89237155
15LATS21.88014538
16PRKD31.85370825
17KSR21.80032585
18SIK11.70239578
19OBSCN1.70169163
20MST1R1.70036331
21DMPK1.52383219
22NEK11.51327164
23DDR21.50507243
24PAK61.47827254
25LATS11.43017601
26GRK51.42971461
27TYRO31.42217283
28PDK31.40574444
29PDK41.40574444
30STK381.30243268
31ARAF1.28839274
32MAP3K71.27937769
33MAP2K41.25203361
34WNK11.24511043
35TAOK11.22462802
36CAMK1D1.21493928
37PAK31.20616849
38RET1.18719828
39CAMK1G1.16504025
40PTK61.16371252
41FER1.15566748
42MAP3K21.12253213
43NTRK31.10486272
44NEK91.06697947
45BMX1.04729480
46TESK11.03012357
47PTK21.01473082
48MAP3K131.01421315
49CAMKK11.01260122
50IRAK31.01161943
51TGFBR21.01015073
52DAPK20.99810227
53ALK0.98338508
54ICK0.95143090
55PRKCH0.94434682
56TRPM70.90526931
57FGFR30.88584398
58MTOR0.87225692
59EEF2K0.86637507
60MAPKAPK30.81075870
61ROCK20.81056767
62BCKDK0.78638042
63CDC42BPA0.77630044
64EPHB10.76311828
65LIMK10.76092628
66MAP3K10.74904330
67MAP3K60.73736871
68PDK20.73618377
69MAP3K40.73057205
70PRKD10.72618414
71MARK20.72479222
72MOS0.71049581
73MAP2K10.70737005
74PINK10.70035196
75MAP3K100.69259091
76EPHB20.69236131
77PRKAA10.68642350
78PAK40.67890463
79WNK40.67577476
80CAMK40.66231336
81MARK10.64380379
82PDGFRB0.63882938
83FGFR40.62131858
84ROCK10.61892780
85CAMK2G0.61371057
86MINK10.61276903
87SCYL20.60971857
88MAP3K30.58581146
89PRKG20.57249397
90PAK20.56286917
91LRRK20.55534480
92PDPK10.55225761
93MAPK120.55114838
94JAK10.54019756
95PTK2B0.53083323
96SGK30.52774905
97EPHA20.52027210
98MAP2K30.50109598
99PRKAA20.49997925
100RPS6KC10.49851160
101RPS6KL10.49851160
102MAPK110.48982412
103EPHA40.48220557
104PDK10.46716396
105STK110.46650059
106JAK20.45873187
107PRKD20.44937426
108MUSK0.44809018
109TAOK20.44679348
110MYLK0.44640610
111CAMK2B0.43328500
112CDK50.42518911
113INSRR0.42435863
114MAPK100.42033165
115MET0.41815461
116TIE10.41670751
117RPS6KA20.40672125
118MAPK70.40578102
119PIK3CG0.40423223
120AKT20.39980570
121BRAF0.39954988
122CAMK2D0.39728308
123PIK3CA0.39585327
124HIPK20.39459974
125DYRK1B0.38304968
126ERBB40.38223904
127RPS6KA30.37594971
128MATK0.37578055
129RPS6KB20.37434543
130MAP3K80.32674113
131CDK60.30089441
132STK240.29415077
133SGK4940.29248359
134SGK2230.29248359

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.56140053
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.17943192
3Dilated cardiomyopathy_Homo sapiens_hsa054142.13671314
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.13582154
5Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.01147688
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.90736535
7Nitrogen metabolism_Homo sapiens_hsa009101.89830396
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.83117346
9Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.73019120
10Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58829914
11Prion diseases_Homo sapiens_hsa050201.55156989
12Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.39746002
13Insulin resistance_Homo sapiens_hsa049311.38949753
14Fatty acid degradation_Homo sapiens_hsa000711.36235871
15mTOR signaling pathway_Homo sapiens_hsa041501.35786917
16Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.34979215
17Adipocytokine signaling pathway_Homo sapiens_hsa049201.31410431
18Type II diabetes mellitus_Homo sapiens_hsa049301.30276691
19Focal adhesion_Homo sapiens_hsa045101.29224649
20PPAR signaling pathway_Homo sapiens_hsa033201.26903516
21Pentose phosphate pathway_Homo sapiens_hsa000301.26040714
22Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.25086928
23Other glycan degradation_Homo sapiens_hsa005111.21866045
24Insulin signaling pathway_Homo sapiens_hsa049101.20982449
25Propanoate metabolism_Homo sapiens_hsa006401.20521612
26Biosynthesis of amino acids_Homo sapiens_hsa012301.20202228
27Fatty acid metabolism_Homo sapiens_hsa012121.19566483
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.18657648
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.16568371
30Phenylalanine metabolism_Homo sapiens_hsa003601.16292696
31Cardiac muscle contraction_Homo sapiens_hsa042601.15534009
32ECM-receptor interaction_Homo sapiens_hsa045121.15485218
33Thyroid cancer_Homo sapiens_hsa052161.14655496
34Small cell lung cancer_Homo sapiens_hsa052221.11882010
35Glucagon signaling pathway_Homo sapiens_hsa049221.10334381
36Fatty acid biosynthesis_Homo sapiens_hsa000611.09040194
37Insulin secretion_Homo sapiens_hsa049111.08622440
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08585020
39AMPK signaling pathway_Homo sapiens_hsa041521.08136547
40Central carbon metabolism in cancer_Homo sapiens_hsa052301.07842420
41Gastric acid secretion_Homo sapiens_hsa049711.07590952
42Oxytocin signaling pathway_Homo sapiens_hsa049211.07280191
43Arginine biosynthesis_Homo sapiens_hsa002201.05169949
44Cyanoamino acid metabolism_Homo sapiens_hsa004601.03674844
45Carbon metabolism_Homo sapiens_hsa012001.03081866
46Notch signaling pathway_Homo sapiens_hsa043301.02789380
47Arginine and proline metabolism_Homo sapiens_hsa003301.02459876
48Dorso-ventral axis formation_Homo sapiens_hsa043201.02346389
49Aldosterone synthesis and secretion_Homo sapiens_hsa049251.01560133
50Renin secretion_Homo sapiens_hsa049241.01227524
51Bile secretion_Homo sapiens_hsa049761.00588546
52GnRH signaling pathway_Homo sapiens_hsa049120.99718096
53Proteoglycans in cancer_Homo sapiens_hsa052050.98612596
54cGMP-PKG signaling pathway_Homo sapiens_hsa040220.97790937
55Glioma_Homo sapiens_hsa052140.96832046
56Longevity regulating pathway - mammal_Homo sapiens_hsa042110.95619153
57Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.95412032
58Amoebiasis_Homo sapiens_hsa051460.95390470
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95094332
60Salivary secretion_Homo sapiens_hsa049700.93738700
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.92829727
62Long-term potentiation_Homo sapiens_hsa047200.90625978
63Estrogen signaling pathway_Homo sapiens_hsa049150.90321919
64Adherens junction_Homo sapiens_hsa045200.85960559
65Pancreatic cancer_Homo sapiens_hsa052120.84890112
66VEGF signaling pathway_Homo sapiens_hsa043700.83788458
67Tight junction_Homo sapiens_hsa045300.82554298
68Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.82360399
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.81173525
70Circadian entrainment_Homo sapiens_hsa047130.80693951
71Synaptic vesicle cycle_Homo sapiens_hsa047210.79292864
72Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.79087602
73Bladder cancer_Homo sapiens_hsa052190.77957830
74Glycosaminoglycan degradation_Homo sapiens_hsa005310.77273695
75MicroRNAs in cancer_Homo sapiens_hsa052060.75705586
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75657845
77cAMP signaling pathway_Homo sapiens_hsa040240.75109853
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.74238881
79Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73376356
80Gap junction_Homo sapiens_hsa045400.73121096
81Neurotrophin signaling pathway_Homo sapiens_hsa047220.72583186
82Protein digestion and absorption_Homo sapiens_hsa049740.72368315
83Axon guidance_Homo sapiens_hsa043600.72338059
84Cholinergic synapse_Homo sapiens_hsa047250.72255962
85Leukocyte transendothelial migration_Homo sapiens_hsa046700.72183175
86Calcium signaling pathway_Homo sapiens_hsa040200.71694620
87Olfactory transduction_Homo sapiens_hsa047400.70358872
88GABAergic synapse_Homo sapiens_hsa047270.70279687
89AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70226243
90Fructose and mannose metabolism_Homo sapiens_hsa000510.69553373
91Circadian rhythm_Homo sapiens_hsa047100.68970762
92Starch and sucrose metabolism_Homo sapiens_hsa005000.68325596
93Acute myeloid leukemia_Homo sapiens_hsa052210.67201853
94Complement and coagulation cascades_Homo sapiens_hsa046100.67062023
95Hippo signaling pathway_Homo sapiens_hsa043900.65684764
96Prostate cancer_Homo sapiens_hsa052150.65399568
97Butanoate metabolism_Homo sapiens_hsa006500.64642414
98Viral myocarditis_Homo sapiens_hsa054160.64582990
99Endometrial cancer_Homo sapiens_hsa052130.64453897
100Lysine degradation_Homo sapiens_hsa003100.64201000
101Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63599510
102Renal cell carcinoma_Homo sapiens_hsa052110.63572563
103Melanogenesis_Homo sapiens_hsa049160.63325266
104Dopaminergic synapse_Homo sapiens_hsa047280.61895292
105Phosphatidylinositol signaling system_Homo sapiens_hsa040700.61853194
106Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61602955
107Tryptophan metabolism_Homo sapiens_hsa003800.61302967
108HIF-1 signaling pathway_Homo sapiens_hsa040660.61158368
109Galactose metabolism_Homo sapiens_hsa000520.60315326
110Rap1 signaling pathway_Homo sapiens_hsa040150.59784767
111Pyruvate metabolism_Homo sapiens_hsa006200.59526488
112Chronic myeloid leukemia_Homo sapiens_hsa052200.58392695
113PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58312573
114Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57724184
115Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.57554564
116Thyroid hormone synthesis_Homo sapiens_hsa049180.57428675
117Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.56517338
118Histidine metabolism_Homo sapiens_hsa003400.56004390
119Non-small cell lung cancer_Homo sapiens_hsa052230.55680343
120ErbB signaling pathway_Homo sapiens_hsa040120.54340020
121Glycerolipid metabolism_Homo sapiens_hsa005610.54240778
122Inositol phosphate metabolism_Homo sapiens_hsa005620.53391794
123Ovarian steroidogenesis_Homo sapiens_hsa049130.52740547
124Amphetamine addiction_Homo sapiens_hsa050310.52676892
125Glutamatergic synapse_Homo sapiens_hsa047240.51883559
126Choline metabolism in cancer_Homo sapiens_hsa052310.51681478
127Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51247253
128Pathways in cancer_Homo sapiens_hsa052000.50559753
129Vitamin B6 metabolism_Homo sapiens_hsa007500.47176322
130Prolactin signaling pathway_Homo sapiens_hsa049170.46608457

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