NFE2L2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.87127036
2positive regulation by organism of defense response of other organism involved in symbiotic interact4.87127036
3modulation by symbiont of host immune response (GO:0052553)4.87127036
4positive regulation by symbiont of host defense response (GO:0052509)4.87127036
5modulation by symbiont of host defense response (GO:0052031)4.87127036
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.87127036
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.83725409
8neutrophil activation involved in immune response (GO:0002283)4.58703858
9response to peptidoglycan (GO:0032494)4.29940374
10regulation of vitamin D biosynthetic process (GO:0060556)3.92200258
11positive regulation of interferon-alpha production (GO:0032727)3.88548018
12regulation of interferon-beta biosynthetic process (GO:0045357)3.79030487
13macrophage activation involved in immune response (GO:0002281)3.72805326
14regulation of interferon-alpha production (GO:0032647)3.67068013
15immunoglobulin mediated immune response (GO:0016064)3.62229947
16regulation of vitamin metabolic process (GO:0030656)3.55986131
17lipopolysaccharide-mediated signaling pathway (GO:0031663)3.53771993
18positive regulation of chemokine biosynthetic process (GO:0045080)3.51603843
19negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.41404936
20hydrogen peroxide biosynthetic process (GO:0050665)3.33465280
21positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.32697107
22positive regulation of cellular amide metabolic process (GO:0034250)3.31202116
23positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.27281175
24response to host immune response (GO:0052572)3.19329599
25response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.19329599
26granulocyte activation (GO:0036230)3.16727082
27microglial cell activation (GO:0001774)3.16576468
28positive regulation of extracellular matrix organization (GO:1903055)3.15630011
29regulation of chemokine biosynthetic process (GO:0045073)3.11347974
30neutrophil activation (GO:0042119)3.10008304
31response to muramyl dipeptide (GO:0032495)3.05051540
32respiratory burst (GO:0045730)3.03470434
33detection of molecule of bacterial origin (GO:0032490)3.00454631
34response to host (GO:0075136)2.97255247
35response to host defenses (GO:0052200)2.97255247
36response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.97255247
37reactive oxygen species biosynthetic process (GO:1903409)2.96486369
38negative regulation of lipid storage (GO:0010888)2.95857760
39positive regulation of interferon-beta production (GO:0032728)2.93488302
40cellular response to thyroid hormone stimulus (GO:0097067)2.91166851
41natural killer cell mediated cytotoxicity (GO:0042267)2.90045989
42natural killer cell mediated immunity (GO:0002228)2.90045989
43positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.89235685
44regulation of cholesterol storage (GO:0010885)2.87620922
45regulation of cytokine secretion involved in immune response (GO:0002739)2.86820887
46response to interferon-alpha (GO:0035455)2.83989144
47positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.83339586
48T-helper 1 type immune response (GO:0042088)2.81952197
49production of molecular mediator involved in inflammatory response (GO:0002532)2.81012064
50positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.79944287
51macrophage activation (GO:0042116)2.79159038
52germinal center formation (GO:0002467)2.78626817
53cell adhesion mediated by integrin (GO:0033627)2.78081588
54regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.77495736
55skin morphogenesis (GO:0043589)2.77280939
56B cell mediated immunity (GO:0019724)2.75819619
57antigen processing and presentation of endogenous antigen (GO:0019883)2.72612720
58response to type I interferon (GO:0034340)2.72271095
59positive regulation of NF-kappaB import into nucleus (GO:0042346)2.71162940
60cellular response to type I interferon (GO:0071357)2.70036465
61type I interferon signaling pathway (GO:0060337)2.70036465
62response to interferon-beta (GO:0035456)2.69797353
63hypotonic response (GO:0006971)2.69023179
64low-density lipoprotein particle clearance (GO:0034383)2.68436353
65myeloid cell activation involved in immune response (GO:0002275)2.67964567
66regulation of heterotypic cell-cell adhesion (GO:0034114)2.67369968
67regulation of mononuclear cell migration (GO:0071675)2.67108146
68antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.64849416
69antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.64849416
70cytokine secretion (GO:0050663)2.62870750
71superoxide anion generation (GO:0042554)2.62765516
72positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.62088427
73positive regulation of type 2 immune response (GO:0002830)2.61839847
74regulation of T-helper 1 cell differentiation (GO:0045625)2.61611326
75I-kappaB phosphorylation (GO:0007252)2.61492161
76positive regulation of heat generation (GO:0031652)2.60477246
77positive regulation of chemokine production (GO:0032722)2.58927440
78regulation of interleukin-12 biosynthetic process (GO:0045075)2.57851635
79positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.57623573
80regulation of podosome assembly (GO:0071801)2.57438495
81regulation of T-helper 2 cell differentiation (GO:0045628)2.55803053
82glycosphingolipid catabolic process (GO:0046479)2.55084308
83response to thyroid hormone (GO:0097066)2.53727008
84leukocyte aggregation (GO:0070486)2.53441759
85regulation of macrophage chemotaxis (GO:0010758)2.52679821
86interferon-gamma-mediated signaling pathway (GO:0060333)2.51606443
87leukocyte mediated cytotoxicity (GO:0001909)2.49978929
88NIK/NF-kappaB signaling (GO:0038061)2.49965529
89positive regulation of tumor necrosis factor production (GO:0032760)2.49735561
90positive regulation of toll-like receptor signaling pathway (GO:0034123)2.49453128
91regulation of dendritic cell antigen processing and presentation (GO:0002604)2.47896254
92wound healing, spreading of epidermal cells (GO:0035313)2.47879644
93negative regulation of complement activation (GO:0045916)2.47313864
94adhesion of symbiont to host cell (GO:0044650)2.46590481
95virion attachment to host cell (GO:0019062)2.46590481
96pinocytosis (GO:0006907)2.46436148
97negative regulation of humoral immune response (GO:0002921)2.46204239
98oligosaccharide catabolic process (GO:0009313)2.45730477
99regulation of interleukin-8 biosynthetic process (GO:0045414)2.45514614
100positive regulation of interleukin-6 production (GO:0032755)2.45356801
101defense response to protozoan (GO:0042832)2.44743819
102negative regulation of interleukin-12 production (GO:0032695)2.44440120
103regulation of fever generation (GO:0031620)2.44382544
104negative regulation of nitric oxide biosynthetic process (GO:0045019)2.42666517
105response to protozoan (GO:0001562)2.42583713
106cellular extravasation (GO:0045123)2.42550296
107regulation of mast cell degranulation (GO:0043304)2.42545615
108monocyte chemotaxis (GO:0002548)2.41568659
109cellular response to virus (GO:0098586)2.41436512
110positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.40997951
111apoptotic cell clearance (GO:0043277)2.40488037
112detection of external biotic stimulus (GO:0098581)2.39291960
113positive regulation of antigen processing and presentation (GO:0002579)2.39269866
114regulation of membrane protein ectodomain proteolysis (GO:0051043)2.38789593
115cellular response to exogenous dsRNA (GO:0071360)2.37942807
116cellular response to interferon-alpha (GO:0035457)2.36362357
117positive regulation of natural killer cell differentiation (GO:0032825)2.35105657
118glycolipid catabolic process (GO:0019377)2.34942833
119neutrophil mediated immunity (GO:0002446)2.33721461
120cellular response to interferon-beta (GO:0035458)2.33141059
121positive regulation of interleukin-12 production (GO:0032735)2.32577432
122regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.32225175
123negative regulation of protein activation cascade (GO:2000258)2.30676991
124desmosome organization (GO:0002934)2.30599409
125peptide catabolic process (GO:0043171)2.30549317
126positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.30470017
127negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.30273216
128myeloid dendritic cell differentiation (GO:0043011)2.29878374
129protein localization to endosome (GO:0036010)2.29722343
130positive regulation of leukocyte degranulation (GO:0043302)2.29474550
131adhesion of symbiont to host (GO:0044406)2.29339578
132regulation of chronic inflammatory response (GO:0002676)2.28951100
133cellular response to lipopolysaccharide (GO:0071222)2.27689232
134negative regulation of cytokine production involved in immune response (GO:0002719)2.24999584
135cellular response to ethanol (GO:0071361)2.23232081
136regulation of type 2 immune response (GO:0002828)2.23178948
137regulation of nitric oxide biosynthetic process (GO:0045428)2.22831819
138iron ion import (GO:0097286)2.22279521
139positive regulation of nitric oxide biosynthetic process (GO:0045429)2.21952860
140detection of other organism (GO:0098543)2.21377285
141positive regulation of natural killer cell activation (GO:0032816)2.17416157
142decidualization (GO:0046697)2.16465661
143regulation of vascular endothelial growth factor production (GO:0010574)2.15061176
144negative regulation of interleukin-17 production (GO:0032700)2.14850654
145positive regulation of Cdc42 GTPase activity (GO:0043089)2.13927931
146positive regulation of acute inflammatory response (GO:0002675)2.12608131
147keratan sulfate catabolic process (GO:0042340)2.12410887
148surfactant homeostasis (GO:0043129)2.11921939
149negative regulation of myeloid cell apoptotic process (GO:0033033)2.11635528
150regulation of tolerance induction (GO:0002643)2.11053474
151barbed-end actin filament capping (GO:0051016)2.10210669
152positive regulation of gamma-delta T cell activation (GO:0046645)2.10053353

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.01193787
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.75477294
3IRF8_21731497_ChIP-ChIP_J774_Mouse4.56577360
4TP63_17297297_ChIP-ChIP_HaCaT_Human3.35474328
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.25884822
6IRF8_27001747_Chip-Seq_BMDM_Mouse3.14187462
7SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.09609746
8* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.96892238
9* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.89641053
10Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.88205072
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.79752702
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.73329376
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.68295537
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.68180193
15FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.60591599
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.60093407
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.58743819
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.45146813
19NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.44078334
20STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.24763334
21STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.24378942
22NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.18486685
23* RXR_22158963_ChIP-Seq_LIVER_Mouse2.07995015
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.06818928
25RARG_19884340_ChIP-ChIP_MEFs_Mouse2.03944025
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.00600366
27* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.99531171
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.98390798
29SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.94379709
30BRD4_27068464_Chip-Seq_AML-cells_Mouse1.92860778
31STAT4_19710469_ChIP-ChIP_TH1__Mouse1.86776204
32GATA1_22025678_ChIP-Seq_K562_Human1.81940753
33* LXR_22158963_ChIP-Seq_LIVER_Mouse1.81108607
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.76628354
35SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.70960843
36* SPI1_23547873_ChIP-Seq_NB4_Human1.68086149
37TRIM28_21343339_ChIP-Seq_HEK293_Human1.58254657
38* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.57751874
39SCL_19346495_ChIP-Seq_HPC-7_Human1.51706526
40CLOCK_20551151_ChIP-Seq_293T_Human1.51130704
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.48676487
42* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.47654199
43VDR_24763502_ChIP-Seq_THP-1_Human1.46345535
44CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.44399205
45ZNF217_24962896_ChIP-Seq_MCF-7_Human1.40233263
46RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.38531789
47PU_27001747_Chip-Seq_BMDM_Mouse1.37065551
48* MYB_26560356_Chip-Seq_TH2_Human1.36343080
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.36164415
50CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35834051
51ESR1_21235772_ChIP-Seq_MCF-7_Human1.34034055
52PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32954520
53ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32469056
54CDX2_19796622_ChIP-Seq_MESCs_Mouse1.32118600
55SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.31567355
56SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.31567355
57MAF_26560356_Chip-Seq_TH1_Human1.29493542
58NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.27962735
59CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.27097727
60JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.26710055
61SOX2_20726797_ChIP-Seq_SW620_Human1.25834616
62HIF1A_21447827_ChIP-Seq_MCF-7_Human1.25595774
63RUNX_20019798_ChIP-Seq_JUKART_Human1.25488159
64GATA1_19941826_ChIP-Seq_K562_Human1.25373495
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.23257397
66VDR_24787735_ChIP-Seq_THP-1_Human1.22224459
67* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.20785626
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19725992
69ESR1_20079471_ChIP-ChIP_T-47D_Human1.18443898
70* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.18028397
71TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17644406
72* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.17223112
73* SPI1_23127762_ChIP-Seq_K562_Human1.13986991
74SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13454994
75NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.12531348
76* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12408889
77* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12347034
78FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.12093378
79MYB_26560356_Chip-Seq_TH1_Human1.11952926
80PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11182264
81ELK3_25401928_ChIP-Seq_HUVEC_Human1.10211886
82* GATA4_25053715_ChIP-Seq_YYC3_Human1.10155169
83* TP63_23658742_ChIP-Seq_EP156T_Human1.09020548
84* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.07063192
85PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06797699
86NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06630155
87FOXO3_23340844_ChIP-Seq_DLD1_Human1.06446155
88FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05953030
89FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.05035656
90TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.05011793
91* FOXA2_19822575_ChIP-Seq_HepG2_Human1.04628214
92VDR_21846776_ChIP-Seq_THP-1_Human1.04573428
93* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.04238742
94* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03670204
95GATA2_19941826_ChIP-Seq_K562_Human1.03607010
96GATA2_22383799_ChIP-Seq_G1ME_Mouse1.03308462
97STAT6_21828071_ChIP-Seq_BEAS2B_Human1.02649224
98CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01506358
99SALL4_18804426_ChIP-ChIP_XEN_Mouse1.01293311
100CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00793067
101JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00770734
102CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.00733750
103VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00525156
104* TBX20_22328084_ChIP-Seq_HEART_Mouse0.98842169
105* TBX20_22080862_ChIP-Seq_HEART_Mouse0.98842169
106BRD4_25478319_ChIP-Seq_HGPS_Human0.98836278
107HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.98028286
108P63_26484246_Chip-Seq_KERATINOCYTES_Human0.97902346
109RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.97591951
110* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95224536
111MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95032890
112TP53_16413492_ChIP-PET_HCT116_Human0.94737630
113* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92611114
114* CJUN_26792858_Chip-Seq_BT549_Human0.92288071
115ESR2_21235772_ChIP-Seq_MCF-7_Human0.92116092
116STAT3_1855785_ChIP-Seq_MESCs_Mouse0.91806148
117CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91001140
118LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.90795002
119* GATA6_25053715_ChIP-Seq_YYC3_Human0.90783739
120GATA3_27048872_Chip-Seq_THYMUS_Human0.89607387
121* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.88624777
122PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88546963
123FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.88145269
124NRF2_20460467_ChIP-Seq_MEFs_Mouse0.87748583
125NFIB_24661679_ChIP-Seq_LUNG_Mouse0.87687079
126BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.87442408

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.16361311
2MP0009785_altered_susceptibility_to3.09200088
3MP0003436_decreased_susceptibility_to3.03192655
4MP0003724_increased_susceptibility_to2.84372911
5MP0002148_abnormal_hypersensitivity_rea2.53512906
6* MP0002419_abnormal_innate_immunity2.41808912
7MP0006082_CNS_inflammation2.41342930
8MP0005058_abnormal_lysosome_morphology2.39258472
9MP0005025_abnormal_response_to2.24627418
10MP0003191_abnormal_cellular_cholesterol2.18026119
11MP0003303_peritoneal_inflammation2.16656617
12* MP0005000_abnormal_immune_tolerance2.13809539
13MP0009840_abnormal_foam_cell2.07412236
14MP0005451_abnormal_body_composition1.93734926
15* MP0002452_abnormal_antigen_presenting1.87751444
16MP0009764_decreased_sensitivity_to1.87584520
17MP0000685_abnormal_immune_system1.86976596
18MP0001853_heart_inflammation1.86046121
19MP0005387_immune_system_phenotype1.81007666
20MP0001790_abnormal_immune_system1.81007666
21MP0004947_skin_inflammation1.80288167
22MP0001533_abnormal_skeleton_physiology1.78175228
23MP0003300_gastrointestinal_ulcer1.77222820
24MP0005464_abnormal_platelet_physiology1.76657052
25MP0000343_altered_response_to1.73320186
26* MP0002723_abnormal_immune_serum1.70034688
27MP0010234_abnormal_vibrissa_follicle1.69214602
28* MP0001800_abnormal_humoral_immune1.66340796
29MP0003950_abnormal_plasma_membrane1.61869031
30* MP0001845_abnormal_inflammatory_respons1.55396033
31MP0002877_abnormal_melanocyte_morpholog1.55264336
32* MP0010155_abnormal_intestine_physiology1.54787856
33MP0005671_abnormal_response_to1.53016326
34MP0008438_abnormal_cutaneous_collagen1.52655198
35* MP0001819_abnormal_immune_cell1.51426090
36MP0004782_abnormal_surfactant_physiolog1.51342272
37MP0006054_spinal_hemorrhage1.51143614
38* MP0002420_abnormal_adaptive_immunity1.49126605
39MP0003448_altered_tumor_morphology1.49060186
40MP0003705_abnormal_hypodermis_morpholog1.48599386
41MP0005167_abnormal_blood-brain_barrier1.47891310
42* MP0008469_abnormal_protein_level1.46721842
43MP0010352_gastrointestinal_tract_polyps1.46671717
44* MP0002405_respiratory_system_inflammati1.46132976
45MP0002139_abnormal_hepatobiliary_system1.44756367
46MP0002006_tumorigenesis1.44146430
47MP0009278_abnormal_bone_marrow1.44126353
48* MP0003186_abnormal_redox_activity1.43073582
49MP0000858_altered_metastatic_potential1.42672090
50* MP0003656_abnormal_erythrocyte_physiolo1.39197351
51MP0003806_abnormal_nucleotide_metabolis1.38787556
52MP0005397_hematopoietic_system_phenotyp1.38150333
53MP0001545_abnormal_hematopoietic_system1.38150333
54MP0005360_urolithiasis1.37688162
55MP0002138_abnormal_hepatobiliary_system1.35384154
56MP0002254_reproductive_system_inflammat1.35232939
57MP0003566_abnormal_cell_adhesion1.33415050
58MP0000465_gastrointestinal_hemorrhage1.27985161
59MP0005023_abnormal_wound_healing1.27162811
60MP0001958_emphysema1.26849566
61MP0003828_pulmonary_edema1.26148185
62MP0004510_myositis1.25140094
63MP0008004_abnormal_stomach_pH1.22811174
64MP0003453_abnormal_keratinocyte_physiol1.22577074
65MP0003195_calcinosis1.22532807
66MP0002166_altered_tumor_susceptibility1.19262340
67MP0002998_abnormal_bone_remodeling1.18002065
68MP0005164_abnormal_response_to1.16780623
69MP0005166_decreased_susceptibility_to1.16493890
70MP0003252_abnormal_bile_duct1.09441496
71MP0008875_abnormal_xenobiotic_pharmacok1.08350950
72MP0003172_abnormal_lysosome_physiology1.08171873
73* MP0003075_altered_response_to1.07833810
74MP0005083_abnormal_biliary_tract1.05524712
75MP0001542_abnormal_bone_strength1.05335039
76* MP0000716_abnormal_immune_system1.05242326
77MP0002060_abnormal_skin_morphology1.04161268
78MP0003279_aneurysm1.02926631
79MP0001216_abnormal_epidermal_layer1.00021390
80MP0002796_impaired_skin_barrier0.99206847
81* MP0009333_abnormal_splenocyte_physiolog0.98848277
82* MP0009763_increased_sensitivity_to0.98836028
83MP0005390_skeleton_phenotype0.97770407
84MP0000249_abnormal_blood_vessel0.94819914
85MP0005076_abnormal_cell_differentiation0.93756402
86* MP0002398_abnormal_bone_marrow0.93243808
87MP0010307_abnormal_tumor_latency0.92514244
88MP0005085_abnormal_gallbladder_physiolo0.92383413
89MP0003183_abnormal_peptide_metabolism0.92066593
90MP0000490_abnormal_crypts_of0.91884714
91* MP0000609_abnormal_liver_physiology0.90848502
92MP0002933_joint_inflammation0.90126555
93MP0002896_abnormal_bone_mineralization0.89814651
94* MP0002429_abnormal_blood_cell0.89741291
95MP0008260_abnormal_autophagy0.89396409
96MP0003795_abnormal_bone_structure0.89363171
97* MP0005165_increased_susceptibility_to0.89165146
98MP0005365_abnormal_bile_salt0.88634804
99MP0005310_abnormal_salivary_gland0.88633212
100MP0010678_abnormal_skin_adnexa0.88544570
101MP0002332_abnormal_exercise_endurance0.88512894
102* MP0000689_abnormal_spleen_morphology0.88386171
103MP0005257_abnormal_intraocular_pressure0.86683779
104MP0003045_fibrosis0.86356606
105MP0000604_amyloidosis0.85962667
106MP0005275_abnormal_skin_tensile0.84794402
107MP0001873_stomach_inflammation0.84161271
108* MP0002136_abnormal_kidney_physiology0.83488761
109MP0003690_abnormal_glial_cell0.83218284
110MP0002168_other_aberrant_phenotype0.82052338
111MP0001666_abnormal_nutrient_absorption0.82018321
112MP0000920_abnormal_myelination0.81626935
113MP0004883_abnormal_blood_vessel0.81079176
114* MP0002722_abnormal_immune_system0.81029443
115* MP0005319_abnormal_enzyme/_coenzyme0.80947189
116MP0000767_abnormal_smooth_muscle0.80199623
117MP0010368_abnormal_lymphatic_system0.79968308
118MP0001851_eye_inflammation0.79439784
119MP0004272_abnormal_basement_membrane0.78023094
120MP0003091_abnormal_cell_migration0.77587221
121* MP0009643_abnormal_urine_homeostasis0.76370076
122MP0002132_abnormal_respiratory_system0.76274721
123MP0000371_diluted_coat_color0.75636157
124MP0003763_abnormal_thymus_physiology0.74547600
125MP0010329_abnormal_lipoprotein_level0.73773101

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)5.75188783
2Eczematoid dermatitis (HP:0000976)5.56687672
3Recurrent bacterial skin infections (HP:0005406)5.26422258
4Recurrent gram-negative bacterial infections (HP:0005420)4.82617232
5Abnormality of macrophages (HP:0004311)4.14633319
6Systemic lupus erythematosus (HP:0002725)3.98524876
7Vacuolated lymphocytes (HP:0001922)3.94287129
8Interstitial pulmonary disease (HP:0006530)3.86952284
9Elevated erythrocyte sedimentation rate (HP:0003565)3.81157949
10Autoimmune thrombocytopenia (HP:0001973)3.77766509
11Mediastinal lymphadenopathy (HP:0100721)3.62916704
12Gingivitis (HP:0000230)3.44874647
13Orchitis (HP:0100796)3.44015939
14Myositis (HP:0100614)3.39406043
15Increased cerebral lipofuscin (HP:0011813)3.38225633
16Pustule (HP:0200039)3.35125136
17Increased neuronal autofluorescent lipopigment (HP:0002074)3.28699091
18Recurrent skin infections (HP:0001581)3.14283918
19Axonal loss (HP:0003447)3.14211580
20Stomatitis (HP:0010280)3.00265688
21Osteolytic defects of the hand bones (HP:0009699)2.93962389
22Osteolytic defects of the phalanges of the hand (HP:0009771)2.93962389
23Myocardial infarction (HP:0001658)2.91457230
24Periodontitis (HP:0000704)2.90782638
25Glomerulonephritis (HP:0000099)2.89065094
26Spondylolisthesis (HP:0003302)2.82564928
27Thick nail (HP:0001805)2.81436146
28Retrobulbar optic neuritis (HP:0100654)2.79989323
29Optic neuritis (HP:0100653)2.79989323
30Hematochezia (HP:0002573)2.76696892
31Recurrent fungal infections (HP:0002841)2.73621821
32Protrusio acetabuli (HP:0003179)2.66208828
33Esophageal varix (HP:0002040)2.62431838
34Vasculitis (HP:0002633)2.57319144
35Urticaria (HP:0001025)2.54401569
36Dysostosis multiplex (HP:0000943)2.53796519
37Nephritis (HP:0000123)2.51528412
38Nausea (HP:0002018)2.48982361
39Tetraparesis (HP:0002273)2.48678127
40Vascular tortuosity (HP:0004948)2.40563742
41Basal ganglia calcification (HP:0002135)2.39795027
42Alopecia of scalp (HP:0002293)2.36653903
43Arterial tortuosity (HP:0005116)2.35069174
44Urinary glycosaminoglycan excretion (HP:0003541)2.35021993
45Mucopolysacchariduria (HP:0008155)2.35021993
46Neurofibrillary tangles (HP:0002185)2.33793634
47Cellulitis (HP:0100658)2.30368263
48Osteomyelitis (HP:0002754)2.29477980
49Recurrent viral infections (HP:0004429)2.28130680
50Peritonitis (HP:0002586)2.26101500
51Aortic aneurysm (HP:0004942)2.26049802
52Nuclear cataract (HP:0100018)2.24809960
53Gingival bleeding (HP:0000225)2.24777280
54Disinhibition (HP:0000734)2.24461723
55Abnormality of complement system (HP:0005339)2.19247444
56Prostate neoplasm (HP:0100787)2.19171590
57Chronic obstructive pulmonary disease (HP:0006510)2.18710955
58Obstructive lung disease (HP:0006536)2.18710955
59Purpura (HP:0000979)2.18092580
60Abnormality of the nasal mucosa (HP:0000433)2.17896412
61Increased CSF protein (HP:0002922)2.16496301
62Vertebral compression fractures (HP:0002953)2.15745513
63Joint hemorrhage (HP:0005261)2.14859244
64Hepatosplenomegaly (HP:0001433)2.13035811
65Abnormality of mucopolysaccharide metabolism (HP:0011020)2.13003356
66Abnormality of polysaccharide metabolism (HP:0011012)2.13003356
67Abnormality of glycosaminoglycan metabolism (HP:0004371)2.13003356
68Complement deficiency (HP:0004431)2.12850223
69Anorexia (HP:0002039)2.11186603
70Petechiae (HP:0000967)2.10878661
71Gangrene (HP:0100758)2.10134381
72Malnutrition (HP:0004395)2.09658737
73Increased serum ferritin (HP:0003281)2.09400102
74Gastrointestinal infarctions (HP:0005244)2.08996430
75Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.08100408
76Aortic dissection (HP:0002647)2.07897736
77Arterial thrombosis (HP:0004420)2.07822298
78Spontaneous hematomas (HP:0007420)2.07814428
79Pulmonary infiltrates (HP:0002113)2.05138274
80Abnormality of the vasculature of the conjunctiva (HP:0008054)2.04838044
81Amyloidosis (HP:0011034)2.00364846
82Deep venous thrombosis (HP:0002625)2.00283877
83Increased IgE level (HP:0003212)1.99993749
84Mitral stenosis (HP:0001718)1.99482444
85Leukocytosis (HP:0001974)1.98489067
86Abnormality of proline metabolism (HP:0010907)1.97352387
87Hydroxyprolinuria (HP:0003080)1.97352387
88Nasal polyposis (HP:0100582)1.97145095
89Abnormality of iron homeostasis (HP:0011031)1.93324688
90Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.92827133
91Cervical subluxation (HP:0003308)1.92326867
92Bone pain (HP:0002653)1.90641589
93Premature loss of primary teeth (HP:0006323)1.90314689
94Asymmetric septal hypertrophy (HP:0001670)1.89436054
95Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.87559781
96Hemoptysis (HP:0002105)1.87515578
97Coarse hair (HP:0002208)1.87032923
98Abnormality of monocarboxylic acid metabolism (HP:0010996)1.85421092
99Abnormality of glutamine family amino acid metabolism (HP:0010902)1.85232335
100Xanthomatosis (HP:0000991)1.84255277
101Skin ulcer (HP:0200042)1.82791927
102Keratoconjunctivitis (HP:0001096)1.80217049
103Epistaxis (HP:0000421)1.79460448
104Aneurysm (HP:0002617)1.79204242
105Metaphyseal irregularity (HP:0003025)1.79110005
106Pathologic fracture (HP:0002756)1.79071118
107Loss of speech (HP:0002371)1.78074560
108Abnormality of glycosphingolipid metabolism (HP:0004343)1.77026913
109Abnormality of glycolipid metabolism (HP:0010969)1.77026913
110Abnormality of liposaccharide metabolism (HP:0010968)1.77026913
111Recurrent pneumonia (HP:0006532)1.75711174
112Keratoconjunctivitis sicca (HP:0001097)1.75295035
113Premature rupture of membranes (HP:0001788)1.74409395
114Abnormality of the pericardium (HP:0001697)1.74377563
115Absent frontal sinuses (HP:0002688)1.73919585
116Polycythemia (HP:0001901)1.73762507
117Follicular hyperkeratosis (HP:0007502)1.73459019
118Agnosia (HP:0010524)1.72678344
119Cerebral inclusion bodies (HP:0100314)1.71113609
120Autoimmune hemolytic anemia (HP:0001890)1.70959232
121Micronodular cirrhosis (HP:0001413)1.70591304
122Increased IgM level (HP:0003496)1.70291699
123Chronic mucocutaneous candidiasis (HP:0002728)1.68867807
124Recurrent cutaneous fungal infections (HP:0011370)1.68867807
125Steatorrhea (HP:0002570)1.68564432
126Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.67956343
127Cardiovascular calcification (HP:0011915)1.67496996
128Abnormality of transition element cation homeostasis (HP:0011030)1.67360224
129Fat malabsorption (HP:0002630)1.67116180
130Abnormality of the common coagulation pathway (HP:0010990)1.66684874
131Cerebral aneurysm (HP:0004944)1.66446725
132Ovoid vertebral bodies (HP:0003300)1.66097859
133Colitis (HP:0002583)1.65827871
134Flat acetabular roof (HP:0003180)1.64894735
135Hemorrhage of the eye (HP:0011885)1.64421236
136Poor head control (HP:0002421)1.63841723
137Diaphragmatic weakness (HP:0009113)1.63707630
138Vascular calcification (HP:0004934)1.62935614
139Dilatation of the ascending aorta (HP:0005111)1.61812817
140Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.60713557
141Progressive neurologic deterioration (HP:0002344)1.59578497

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.32074246
2IRAK32.95053063
3TBK12.91661573
4ERN12.84976175
5DDR22.51709713
6BLK2.45704872
7TYK22.45622921
8TGFBR22.32978330
9PIM22.29741292
10IRAK42.17883199
11PBK2.12791071
12IKBKE2.12020188
13IKBKB2.04697907
14RIPK12.02566591
15RIPK42.01337451
16NEK91.97847172
17GRK71.95892622
18BMPR21.89189283
19MAP4K11.85738741
20MST41.82378316
21JAK31.75271875
22STK101.74762033
23RPS6KA41.73217678
24PRPF4B1.69572145
25EPHA21.59322448
26EPHB11.56986763
27MAP3K31.56608541
28KIT1.56547511
29MAP3K21.55635725
30PDGFRA1.54346133
31TAOK21.53871427
32ZAP701.53011216
33TXK1.50727103
34CHUK1.49509799
35NME21.47808651
36JAK11.46138850
37CSK1.45608663
38CDC42BPA1.44482684
39AKT31.43010990
40MST1R1.38049353
41SIK31.31900525
42MAP2K31.30865419
43LRRK21.26605674
44MAP3K131.20008518
45MAP3K11.18322241
46MATK1.18276506
47FGFR41.17709380
48TRIB31.16725014
49PAK41.13905228
50PTK61.13520575
51TTN1.13124451
52PIM11.11219112
53TAOK31.05890814
54TEC1.04876348
55TRPM71.03024420
56CSF1R1.02262726
57CDK61.00413085
58STK31.00260809
59BMX0.99266399
60FER0.92373933
61TAOK10.91464077
62BTK0.91355535
63FLT30.90514372
64MAP3K120.88323834
65MAP2K20.87756874
66ABL20.87571005
67PKN20.85852635
68JAK20.84702750
69NUAK10.84412133
70MAP3K100.83432143
71FRK0.83388926
72STK40.82972897
73KDR0.81772929
74LYN0.80884563
75SIK10.78711279
76HCK0.76397793
77MAPKAPK30.75159027
78EPHA30.74410594
79TGFBR10.71844933
80PRKG20.70627290
81TESK10.67479004
82LCK0.66581144
83FGFR30.65610273
84MAP3K60.64747758
85DMPK0.63751632
86STK240.63124755
87MET0.63041884
88MAPK70.62354670
89MELK0.61850863
90MOS0.61209820
91LMTK20.60368894
92EGFR0.59324645
93EIF2AK20.59161455
94ABL10.58968781
95LATS10.58768723
96LATS20.58543399
97SGK30.58102875
98ERBB40.57451377
99PIK3CG0.57317561
100CDK120.56122168
101SYK0.55349214
102PDK20.54499552
103PDPK10.54356875
104FGR0.53379601
105NEK60.53219178
106MAP3K110.52899088
107MAPKAPK20.52770520
108CAMK1D0.52721547
109ITK0.52037506
110TIE10.51867730
111MARK30.51637447
112ACVR1B0.51614030
113PRKAA20.50048549
114MAP3K80.47840736
115CDK90.47809250
116MAP3K50.47582717
117NLK0.47489946
118* PRKCD0.47276832
119HIPK20.47120391
120PDGFRB0.46905428
121GRK60.46645021
122STK380.46334702
123DYRK1B0.42769761
124MAPK110.42734425
125GSK3A0.42636907
126MAP3K70.41467250
127ERBB30.41429874
128ZAK0.40893542
129PTK20.40542514
130ADRBK20.39669263
131MYLK0.39314393
132EIF2AK30.37993469
133RPS6KB20.35220326
134RPS6KA60.35004136
135IRAK10.31377539

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.04401840
2Leishmaniasis_Homo sapiens_hsa051402.89752072
3Legionellosis_Homo sapiens_hsa051342.53121851
4Graft-versus-host disease_Homo sapiens_hsa053322.40826342
5Malaria_Homo sapiens_hsa051442.35968253
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.33617722
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.23182810
8Pertussis_Homo sapiens_hsa051332.06900459
9Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.99846904
10NOD-like receptor signaling pathway_Homo sapiens_hsa046211.92386320
11Osteoclast differentiation_Homo sapiens_hsa043801.83796821
12Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.82611199
13Caffeine metabolism_Homo sapiens_hsa002321.74363024
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.73718345
15TNF signaling pathway_Homo sapiens_hsa046681.72908948
16Tuberculosis_Homo sapiens_hsa051521.72373807
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.70528794
18Lysosome_Homo sapiens_hsa041421.66047283
19Measles_Homo sapiens_hsa051621.60432805
20Allograft rejection_Homo sapiens_hsa053301.58608268
21Complement and coagulation cascades_Homo sapiens_hsa046101.56904014
22Rheumatoid arthritis_Homo sapiens_hsa053231.53938641
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.50949322
24Influenza A_Homo sapiens_hsa051641.44747117
25Hematopoietic cell lineage_Homo sapiens_hsa046401.43712241
26Toxoplasmosis_Homo sapiens_hsa051451.43507683
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.43147566
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.42176388
29Salmonella infection_Homo sapiens_hsa051321.37461406
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.32453146
31African trypanosomiasis_Homo sapiens_hsa051431.30723633
32Other glycan degradation_Homo sapiens_hsa005111.28643611
33Sphingolipid metabolism_Homo sapiens_hsa006001.27867879
34Herpes simplex infection_Homo sapiens_hsa051681.27405937
35Apoptosis_Homo sapiens_hsa042101.25347109
36Antigen processing and presentation_Homo sapiens_hsa046121.22995646
37Asthma_Homo sapiens_hsa053101.22900276
38Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.20985494
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.20590558
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.18169196
41Chemical carcinogenesis_Homo sapiens_hsa052041.17703059
42Phagosome_Homo sapiens_hsa041451.17608146
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.13936594
44Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13563053
45Leukocyte transendothelial migration_Homo sapiens_hsa046701.09116982
46Amoebiasis_Homo sapiens_hsa051461.06140573
47Jak-STAT signaling pathway_Homo sapiens_hsa046301.02651781
48AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.99139311
49Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98919656
50Shigellosis_Homo sapiens_hsa051310.97921059
51Viral myocarditis_Homo sapiens_hsa054160.97778845
52Bladder cancer_Homo sapiens_hsa052190.96597149
53Hepatitis C_Homo sapiens_hsa051600.96020112
54Primary bile acid biosynthesis_Homo sapiens_hsa001200.93324276
55Glutathione metabolism_Homo sapiens_hsa004800.92832525
56B cell receptor signaling pathway_Homo sapiens_hsa046620.92418584
57Histidine metabolism_Homo sapiens_hsa003400.84355607
58Fatty acid degradation_Homo sapiens_hsa000710.83026423
59Hepatitis B_Homo sapiens_hsa051610.82868164
60Type I diabetes mellitus_Homo sapiens_hsa049400.81215770
61Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80934782
62Small cell lung cancer_Homo sapiens_hsa052220.79664209
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.78263645
64Mineral absorption_Homo sapiens_hsa049780.75491163
65Starch and sucrose metabolism_Homo sapiens_hsa005000.75275885
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75068268
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.71406034
68PPAR signaling pathway_Homo sapiens_hsa033200.70440396
69Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66541732
70Sulfur metabolism_Homo sapiens_hsa009200.64031366
71Peroxisome_Homo sapiens_hsa041460.63339112
72Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63218093
73Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63196872
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.62777883
75Chemokine signaling pathway_Homo sapiens_hsa040620.61409019
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.61363751
77Prolactin signaling pathway_Homo sapiens_hsa049170.60519136
78Renin-angiotensin system_Homo sapiens_hsa046140.59908109
79Vitamin digestion and absorption_Homo sapiens_hsa049770.59021584
80Nitrogen metabolism_Homo sapiens_hsa009100.55433833
81Folate biosynthesis_Homo sapiens_hsa007900.55396491
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.55329301
83Chronic myeloid leukemia_Homo sapiens_hsa052200.54783302
84Steroid hormone biosynthesis_Homo sapiens_hsa001400.54431704
85Autoimmune thyroid disease_Homo sapiens_hsa053200.53935044
86Selenocompound metabolism_Homo sapiens_hsa004500.53456241
87Retinol metabolism_Homo sapiens_hsa008300.53390649
88Galactose metabolism_Homo sapiens_hsa000520.52754795
89ECM-receptor interaction_Homo sapiens_hsa045120.52724038
90Focal adhesion_Homo sapiens_hsa045100.52482092
91T cell receptor signaling pathway_Homo sapiens_hsa046600.52164054
92Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.51256536
93Tryptophan metabolism_Homo sapiens_hsa003800.50784943
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50185132
95Steroid biosynthesis_Homo sapiens_hsa001000.49925764
96Prostate cancer_Homo sapiens_hsa052150.49484020
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49418552
98Dorso-ventral axis formation_Homo sapiens_hsa043200.49339938
99ABC transporters_Homo sapiens_hsa020100.48682799
100Fat digestion and absorption_Homo sapiens_hsa049750.48396501
101Endocytosis_Homo sapiens_hsa041440.48176622
102Pentose phosphate pathway_Homo sapiens_hsa000300.47748295
103Acute myeloid leukemia_Homo sapiens_hsa052210.47348712
104Prion diseases_Homo sapiens_hsa050200.47242303
105Circadian rhythm_Homo sapiens_hsa047100.47183423
106Adherens junction_Homo sapiens_hsa045200.46278477
107Phenylalanine metabolism_Homo sapiens_hsa003600.44699253
108Proteoglycans in cancer_Homo sapiens_hsa052050.44488986
109Renal cell carcinoma_Homo sapiens_hsa052110.44223050
110beta-Alanine metabolism_Homo sapiens_hsa004100.44071265
111One carbon pool by folate_Homo sapiens_hsa006700.43640972
112FoxO signaling pathway_Homo sapiens_hsa040680.43485817
113Platelet activation_Homo sapiens_hsa046110.43266999
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.42963561
115Pancreatic cancer_Homo sapiens_hsa052120.42635386
116mTOR signaling pathway_Homo sapiens_hsa041500.42566196
117Neurotrophin signaling pathway_Homo sapiens_hsa047220.42312391
118Fructose and mannose metabolism_Homo sapiens_hsa000510.40672823
119Arginine biosynthesis_Homo sapiens_hsa002200.39115726
120VEGF signaling pathway_Homo sapiens_hsa043700.38885189
121Vibrio cholerae infection_Homo sapiens_hsa051100.38135778
122Insulin resistance_Homo sapiens_hsa049310.37308301
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.37213232
124p53 signaling pathway_Homo sapiens_hsa041150.35505651
125* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34703619

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