NFE2L3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)9.01864434
2polyketide metabolic process (GO:0030638)9.01864434
3doxorubicin metabolic process (GO:0044598)9.01864434
4nuclear pore complex assembly (GO:0051292)6.67706617
5maintenance of protein location in nucleus (GO:0051457)6.25782979
6regulation of response to osmotic stress (GO:0047484)6.17676092
7somite rostral/caudal axis specification (GO:0032525)6.06476192
8negative regulation of epidermis development (GO:0045683)5.95276914
9nuclear pore organization (GO:0006999)5.84853672
10regulation of MHC class I biosynthetic process (GO:0045343)5.71235870
11aminoglycoside antibiotic metabolic process (GO:0030647)5.67547940
12regulation of mammary gland epithelial cell proliferation (GO:0033599)5.24812370
13muscle organ morphogenesis (GO:0048644)5.21053825
14regulation of telomere maintenance via telomerase (GO:0032210)5.10355000
15regulation of posttranscriptional gene silencing (GO:0060147)5.08386025
16regulation of gene silencing by miRNA (GO:0060964)5.08386025
17regulation of gene silencing by RNA (GO:0060966)5.08386025
18pore complex assembly (GO:0046931)5.07179829
19DNA unwinding involved in DNA replication (GO:0006268)5.00106844
20negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.95268901
21ribosome assembly (GO:0042255)4.87813701
22branching involved in mammary gland duct morphogenesis (GO:0060444)4.78413537
23response to dietary excess (GO:0002021)4.61464801
24mitotic sister chromatid cohesion (GO:0007064)4.49952636
25negative regulation of epidermal cell differentiation (GO:0045605)4.48611938
26notochord development (GO:0030903)4.44055925
27hormone catabolic process (GO:0042447)4.43952544
28histone H4-K5 acetylation (GO:0043981)4.42906547
29histone H4-K8 acetylation (GO:0043982)4.42906547
30cytidine deamination (GO:0009972)4.39571695
31cytidine metabolic process (GO:0046087)4.39571695
32cytidine catabolic process (GO:0006216)4.39571695
33establishment of integrated proviral latency (GO:0075713)4.39180429
34nucleoside transmembrane transport (GO:1901642)4.38645098
35transepithelial transport (GO:0070633)4.35612152
36regulation of cilium movement (GO:0003352)4.31235513
37negative regulation of cell cycle G2/M phase transition (GO:1902750)4.28241192
38negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)4.27888309
39regulation of odontogenesis of dentin-containing tooth (GO:0042487)4.20691793
40phenol-containing compound catabolic process (GO:0019336)4.20625536
41regulation of histone H3-K9 methylation (GO:0051570)4.15827071
42protein localization to chromosome, centromeric region (GO:0071459)4.13790968
43pre-miRNA processing (GO:0031054)4.10219055
44DNA duplex unwinding (GO:0032508)4.03917701
45negative regulation of telomerase activity (GO:0051974)4.01698941
46regulation of nuclear cell cycle DNA replication (GO:0033262)3.98591461
47cell fate commitment involved in formation of primary germ layer (GO:0060795)3.97553179
48histone H4-K12 acetylation (GO:0043983)3.93999225
49negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.89340115
50DNA geometric change (GO:0032392)3.88393246
51intestinal epithelial cell development (GO:0060576)3.86858407
52primitive streak formation (GO:0090009)3.79417141
53rRNA transcription (GO:0009303)3.77227865
54cardiovascular system development (GO:0072358)3.76442791
55coenzyme catabolic process (GO:0009109)3.75854673
56bone trabecula formation (GO:0060346)3.73174765
57mitotic chromosome condensation (GO:0007076)3.72109830
58regulation of apoptotic process involved in morphogenesis (GO:1902337)3.66331200
59protein polyglutamylation (GO:0018095)3.64854816
60protein localization to kinetochore (GO:0034501)3.58468441
61DNA replication checkpoint (GO:0000076)3.54966297
62intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.54048721
63positive regulation of SMAD protein import into nucleus (GO:0060391)3.52096609
64protein complex localization (GO:0031503)3.49923182
65mitotic metaphase plate congression (GO:0007080)3.49668773
66hypotonic response (GO:0006971)3.49075134
67icosanoid secretion (GO:0032309)3.47555813
68arachidonic acid secretion (GO:0050482)3.47555813
69DNA replication initiation (GO:0006270)3.45076466
70phosphatidylinositol 3-kinase signaling (GO:0014065)3.42928818
71central nervous system myelination (GO:0022010)3.42921980
72axon ensheathment in central nervous system (GO:0032291)3.42921980
73mitochondrion distribution (GO:0048311)3.42760633
74histone H4-K16 acetylation (GO:0043984)3.41963193
75mitotic sister chromatid segregation (GO:0000070)3.41366536
76establishment of skin barrier (GO:0061436)3.39184265
77positive regulation of chromosome segregation (GO:0051984)3.39016009
78regulation of helicase activity (GO:0051095)3.38494261
79negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.37465863
80microtubule severing (GO:0051013)3.37418533
81negative regulation of DNA repair (GO:0045738)3.37276321
82mitotic nuclear envelope disassembly (GO:0007077)3.33313800
83paraxial mesoderm development (GO:0048339)3.31752752
84detection of temperature stimulus (GO:0016048)3.31747487
85nucleoside transport (GO:0015858)3.31263610
86branching involved in labyrinthine layer morphogenesis (GO:0060670)3.31099360
87establishment of viral latency (GO:0019043)3.29714532
88sister chromatid segregation (GO:0000819)3.29155906
89regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.29045679
90interferon-gamma production (GO:0032609)3.28412395
91negative regulation of histone methylation (GO:0031061)3.26657863
92regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.25533919
93positive regulation of macrophage cytokine production (GO:0060907)3.24749602
94proline transport (GO:0015824)3.21853958
95folic acid-containing compound biosynthetic process (GO:0009396)3.21115101
96anterior/posterior axis specification (GO:0009948)3.18716083
97maintenance of protein localization in organelle (GO:0072595)3.18525438
98DNA strand elongation involved in DNA replication (GO:0006271)3.18047809
99cellular protein complex localization (GO:0034629)3.17748029
100DNA strand renaturation (GO:0000733)3.17659765
101regulation of water loss via skin (GO:0033561)3.15379659
102negative regulation of cell fate commitment (GO:0010454)3.15323314
103regulation of sister chromatid cohesion (GO:0007063)3.14268106
104negative regulation of chromosome segregation (GO:0051985)3.13876564
105positive regulation of DNA-dependent DNA replication (GO:2000105)3.12766471
106membrane disassembly (GO:0030397)3.12058084
107nuclear envelope disassembly (GO:0051081)3.12058084
108regulation of gene silencing (GO:0060968)3.11327034
109positive regulation of catenin import into nucleus (GO:0035413)3.11293777
110regulation of telomere maintenance (GO:0032204)3.11134771
111vitamin A metabolic process (GO:0006776)3.08817515
112quinone metabolic process (GO:1901661)3.08063919
113nucleotide-sugar biosynthetic process (GO:0009226)3.08025992
114negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.07934237
115negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.07934237
116negative regulation of mitotic sister chromatid segregation (GO:0033048)3.07934237
117negative regulation of mitotic sister chromatid separation (GO:2000816)3.07934237
118negative regulation of sister chromatid segregation (GO:0033046)3.07934237
119IMP biosynthetic process (GO:0006188)3.07265489
120ventricular system development (GO:0021591)3.07094547
121regulation of chromosome segregation (GO:0051983)3.06837406
122regulation of cell fate specification (GO:0042659)3.06483015
123negative regulation of viral release from host cell (GO:1902187)3.06465047
124regulation of mitotic metaphase/anaphase transition (GO:0030071)3.04696021
125regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.04696021
126DNA strand elongation (GO:0022616)3.03372332
127regulation of odontogenesis (GO:0042481)3.02887502
128L-serine metabolic process (GO:0006563)3.02792162
129regulation of translational fidelity (GO:0006450)3.02426543
130negative regulation of peptidyl-serine phosphorylation (GO:0033137)3.02101555
131monoubiquitinated protein deubiquitination (GO:0035520)3.00390014
132DNA conformation change (GO:0071103)2.99135657
133regulation of centriole replication (GO:0046599)2.97143250
134regulation of RNA export from nucleus (GO:0046831)2.96140877
135positive regulation of odontogenesis (GO:0042482)2.94991331
136regulation of mitotic sister chromatid separation (GO:0010965)2.94166301
137regulation of mitotic sister chromatid segregation (GO:0033047)2.94166301
138regulation of sister chromatid segregation (GO:0033045)2.94166301
139regulation of microtubule-based movement (GO:0060632)2.92303280
140rRNA methylation (GO:0031167)2.92078061
141L-alpha-amino acid transmembrane transport (GO:1902475)2.91929251
142pyrimidine ribonucleoside catabolic process (GO:0046133)2.91782201
143meiotic chromosome segregation (GO:0045132)2.91582041
144lateral sprouting from an epithelium (GO:0060601)2.91560227
145intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.90817215
146heterochromatin organization (GO:0070828)2.90128016
147regulation of cell fate commitment (GO:0010453)2.89366065
148embryonic axis specification (GO:0000578)2.88639420
149IMP metabolic process (GO:0046040)2.88587673
150omega-hydroxylase P450 pathway (GO:0097267)2.87612367
151hair follicle morphogenesis (GO:0031069)2.87598550
152chromatin assembly (GO:0031497)2.86419488
153myelin maintenance (GO:0043217)2.85965109
154retinoic acid receptor signaling pathway (GO:0048384)2.85939963
155regulation of DNA endoreduplication (GO:0032875)2.84497600
156mitotic spindle checkpoint (GO:0071174)2.84381529
157ovulation cycle (GO:0042698)2.84002222
158regulation of chromatin silencing (GO:0031935)2.83366276
159epoxygenase P450 pathway (GO:0019373)2.82968108
160ncRNA catabolic process (GO:0034661)2.81435459
161tachykinin receptor signaling pathway (GO:0007217)2.81167808
162establishment of endothelial barrier (GO:0061028)2.80487245
163regulation of centrosome cycle (GO:0046605)2.80294794
164epithelial cell differentiation involved in prostate gland development (GO:0060742)2.78955762
165negative regulation of potassium ion transmembrane transport (GO:1901380)2.78901890
166positive regulation of protein deacetylation (GO:0090312)2.78321074
167spindle checkpoint (GO:0031577)2.77455727
168mitotic spindle assembly checkpoint (GO:0007094)2.77246814
169fatty acid derivative transport (GO:1901571)2.76453551
170icosanoid transport (GO:0071715)2.76453551
171regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.75865628
172response to X-ray (GO:0010165)2.75863810
173cellular modified amino acid catabolic process (GO:0042219)2.75521592
174regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.75315718
175regulation of stem cell maintenance (GO:2000036)2.72709755
176metaphase plate congression (GO:0051310)2.72583719
177nucleobase biosynthetic process (GO:0046112)2.70910006
178establishment of apical/basal cell polarity (GO:0035089)2.70736950
179hippo signaling (GO:0035329)2.70299145
180inner cell mass cell proliferation (GO:0001833)2.69776235
181spindle assembly checkpoint (GO:0071173)2.69462562
182histone phosphorylation (GO:0016572)2.68775350
183UDP-N-acetylglucosamine metabolic process (GO:0006047)2.67432103
184nuclear envelope organization (GO:0006998)2.67204217
185double-strand break repair via nonhomologous end joining (GO:0006303)2.66897263
186non-recombinational repair (GO:0000726)2.66897263
187regulation of centrosome duplication (GO:0010824)2.66181665
188embryonic process involved in female pregnancy (GO:0060136)2.64985506
189regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.63026589
190histone-serine phosphorylation (GO:0035404)2.62234275
191DNA synthesis involved in DNA repair (GO:0000731)2.61002249
192lung-associated mesenchyme development (GO:0060484)2.60621565
193telomere maintenance via semi-conservative replication (GO:0032201)2.60513371
194mesodermal cell differentiation (GO:0048333)2.60494230
195CENP-A containing nucleosome assembly (GO:0034080)2.59201695
196positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.57179295
197positive regulation of mitotic sister chromatid separation (GO:1901970)2.57179295

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.55794860
2KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.93684591
3KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.93684591
4KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.93684591
5BP1_19119308_ChIP-ChIP_Hs578T_Human6.81436660
6FOXM1_23109430_ChIP-Seq_U2OS_Human4.52802680
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.39447557
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.31739531
9NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.19453172
10SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.15532352
11SOX2_18358816_ChIP-ChIP_MESCs_Mouse3.02522927
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.95753687
13SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.68446914
14AR_21909140_ChIP-Seq_LNCAP_Human2.59663718
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.58397491
16TCF3_18692474_ChIP-Seq_MESCs_Mouse2.56438260
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.54023811
18KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.52361591
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.49146517
20TP63_19390658_ChIP-ChIP_HaCaT_Human2.44028686
21NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.39383499
22NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.26488266
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.20320012
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.18859403
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.18312517
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.18037336
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.17052930
28POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.11774941
29TCF3_18692474_ChIP-Seq_MEFs_Mouse2.09261452
30SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.02452234
31RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01103621
32EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.99311076
33CDX2_20551321_ChIP-Seq_CACO-2_Human1.92101778
34MYC_22102868_ChIP-Seq_BL_Human1.90875365
35IRF1_19129219_ChIP-ChIP_H3396_Human1.86530171
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.86269964
37TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.85499387
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.81219304
39FOXO3_23340844_ChIP-Seq_DLD1_Human1.80027457
40SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.78218750
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78051884
42HIF1A_21447827_ChIP-Seq_MCF-7_Human1.76554818
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.73864900
44* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.73293663
45* NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.72189249
46ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.67808413
47* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67771515
48NANOG_18692474_ChIP-Seq_MESCs_Mouse1.66085648
49DCP1A_22483619_ChIP-Seq_HELA_Human1.64984185
50* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.64292264
51ZFX_18555785_ChIP-Seq_MESCs_Mouse1.64151460
52ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.62212810
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.61458136
54MYC_18358816_ChIP-ChIP_MESCs_Mouse1.60132192
55XRN2_22483619_ChIP-Seq_HELA_Human1.59273697
56ZFP281_27345836_Chip-Seq_ESCs_Mouse1.55832539
57NOTCH1_21737748_ChIP-Seq_TLL_Human1.54309174
58POU5F1_16518401_ChIP-PET_MESCs_Mouse1.54142090
59STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.52611765
60TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.52323399
61PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.48102086
62ESR1_21235772_ChIP-Seq_MCF-7_Human1.46955827
63TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.45290610
64KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.45233700
65NANOG_18692474_ChIP-Seq_MEFs_Mouse1.43829123
66RING1B_27294783_Chip-Seq_NPCs_Mouse1.43637389
67WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.41210514
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40909555
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39629071
70E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39452400
71STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37354319
72ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31577428
73MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.31553595
74SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.30393627
75SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.30393627
76AHR_22903824_ChIP-Seq_MCF-7_Human1.29454744
77RNF2_27304074_Chip-Seq_NSC_Mouse1.28940087
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28386625
79CREB1_15753290_ChIP-ChIP_HEK293T_Human1.28097730
80ELK1_19687146_ChIP-ChIP_HELA_Human1.27991382
81SOX2_18555785_ChIP-Seq_MESCs_Mouse1.27367914
82CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.25466295
83ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24440350
84ATF3_27146783_Chip-Seq_COLON_Human1.24292552
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23672168
86TFEB_21752829_ChIP-Seq_HELA_Human1.23219575
87SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.23069201
88CHD1_26751641_Chip-Seq_LNCaP_Human1.22565083
89CLOCK_20551151_ChIP-Seq_293T_Human1.22457238
90E2F1_17053090_ChIP-ChIP_MCF-7_Human1.21639885
91KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.20493651
92CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20115326
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19500808
94FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18954581
95TTF2_22483619_ChIP-Seq_HELA_Human1.18764551
96YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18050710
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17819002
98NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.17043533
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16058075
100POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.14986012
101STAT3_18555785_ChIP-Seq_MESCs_Mouse1.14945137
102SOX2_18692474_ChIP-Seq_MESCs_Mouse1.14873181
103* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13922985
104TRIM28_21343339_ChIP-Seq_HEK293_Human1.11767823
105TP53_22127205_ChIP-Seq_IMR90_Human1.11204212
106PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.09140733
107POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.09107830
108* KDM2B_26808549_Chip-Seq_K562_Human1.08292882
109ZNF263_19887448_ChIP-Seq_K562_Human1.08169852
110FOXP3_21729870_ChIP-Seq_TREG_Human1.08148216
111SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07529595
112TBX3_20139965_ChIP-Seq_MESCs_Mouse1.07521569
113EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.06933031
114KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06827436
115TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06055274
116POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05862255
117KLF5_25053715_ChIP-Seq_YYC3_Human1.05093307
118* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04934735
119ARNT_22903824_ChIP-Seq_MCF-7_Human1.04357121
120CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.03195913
121DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02545546
122NANOG_21062744_ChIP-ChIP_HESCs_Human1.01972924
123SMAD3_21741376_ChIP-Seq_HESCs_Human1.01306252
124TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.01289248
125MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00642523
126BMI1_23680149_ChIP-Seq_NPCS_Mouse1.00306027
127SALL1_21062744_ChIP-ChIP_HESCs_Human1.00078218
128TP53_20018659_ChIP-ChIP_R1E_Mouse0.99602510
129CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98790997
130ERG_20887958_ChIP-Seq_HPC-7_Mouse0.98687693
131NANOG_16518401_ChIP-PET_MESCs_Mouse0.98638699
132SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97957716
133* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97697651
134WT1_19549856_ChIP-ChIP_CCG9911_Human0.97400430
135EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97049498
136EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95535728
137JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.95423650
138IKZF1_21737484_ChIP-ChIP_HCT116_Human0.94685850
139KDM2B_26808549_Chip-Seq_SUP-B15_Human0.94504199
140EOMES_21245162_ChIP-Seq_HESCs_Human0.94405070
141GABP_19822575_ChIP-Seq_HepG2_Human0.94351244
142VDR_21846776_ChIP-Seq_THP-1_Human0.94267091
143HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94109176
144SOX17_20123909_ChIP-Seq_XEN_Mouse0.91588286
145PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91562082
146HOXB4_20404135_ChIP-ChIP_EML_Mouse0.91288465
147THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90959058
148TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.90956584
149UBF1/2_26484160_Chip-Seq_HMECs_Human0.90762332
150RNF2_27304074_Chip-Seq_ESCs_Mouse0.90633186
151EZH2_18974828_ChIP-Seq_MESCs_Mouse0.90477812
152RNF2_18974828_ChIP-Seq_MESCs_Mouse0.90477812
153NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.89617107
154P63_26484246_Chip-Seq_KERATINOCYTES_Human0.89505497
155TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89115011
156* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.88479975
157HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.88256558
158KDM5A_27292631_Chip-Seq_BREAST_Human0.87454923
159WT1_25993318_ChIP-Seq_PODOCYTE_Human0.86395589
160GATA1_26923725_Chip-Seq_HPCs_Mouse0.85338737
161VDR_23849224_ChIP-Seq_CD4+_Human0.85049601
162STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81323550
163FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.80955433
164SOX2_18692474_ChIP-Seq_MEFs_Mouse0.80041263
165* NANOG_16153702_ChIP-ChIP_HESCs_Human0.79167169
166ESR1_20079471_ChIP-ChIP_T-47D_Human0.78426404
167TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.77564311
168RUNX1_27514584_Chip-Seq_MCF-7_Human0.76312354
169SOX9_24532713_ChIP-Seq_HFSC_Mouse0.75643878
170ELK4_26923725_Chip-Seq_MESODERM_Mouse0.74576492
171RING1B_27294783_Chip-Seq_ESCs_Mouse0.74385140
172RACK7_27058665_Chip-Seq_MCF-7_Human0.72993352
173ERG_21242973_ChIP-ChIP_JURKAT_Human0.72654607
174POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.71826441
175TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.71826441
176GATA6_25053715_ChIP-Seq_YYC3_Human0.71713938
177GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.71445515
178CTNNB1_20460455_ChIP-Seq_HCT116_Human0.71160234
179CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.70608803

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002254_reproductive_system_inflammat7.42045666
2MP0004264_abnormal_extraembryonic_tissu4.34959905
3MP0003011_delayed_dark_adaptation3.85032331
4MP0003693_abnormal_embryo_hatching3.84818792
5MP0005499_abnormal_olfactory_system3.39441806
6MP0005394_taste/olfaction_phenotype3.39441806
7MP0006292_abnormal_olfactory_placode3.34605181
8MP0010094_abnormal_chromosome_stability3.23245877
9MP0003111_abnormal_nucleus_morphology3.18786700
10MP0003941_abnormal_skin_development3.16111922
11MP0003890_abnormal_embryonic-extraembry3.05254182
12MP0005075_abnormal_melanosome_morpholog2.85358908
13MP0004858_abnormal_nervous_system2.71373078
14MP0003077_abnormal_cell_cycle2.68064366
15MP0008007_abnormal_cellular_replicative2.50935927
16MP0010678_abnormal_skin_adnexa2.47621639
17MP0000383_abnormal_hair_follicle2.46156391
18MP0000762_abnormal_tongue_morphology2.28516747
19MP0001849_ear_inflammation2.25574435
20MP0002098_abnormal_vibrissa_morphology2.24312983
21MP0001730_embryonic_growth_arrest2.22826895
22MP0004381_abnormal_hair_follicle2.17560586
23MP0002796_impaired_skin_barrier2.16123306
24MP0003566_abnormal_cell_adhesion2.13019287
25MP0003718_maternal_effect2.12085356
26MP0010234_abnormal_vibrissa_follicle2.05325235
27MP0003122_maternal_imprinting2.05243372
28MP0003938_abnormal_ear_development2.03125629
29MP0002332_abnormal_exercise_endurance2.03111274
30MP0005076_abnormal_cell_differentiation2.01757985
31MP0010307_abnormal_tumor_latency1.99951094
32MP0002277_abnormal_respiratory_mucosa1.97002970
33MP0000678_abnormal_parathyroid_gland1.92607907
34MP0008057_abnormal_DNA_replication1.90927914
35MP0008932_abnormal_embryonic_tissue1.89803428
36MP0001348_abnormal_lacrimal_gland1.83078524
37MP0008789_abnormal_olfactory_epithelium1.77656067
38MP0008058_abnormal_DNA_repair1.74946130
39MP0010030_abnormal_orbit_morphology1.66264666
40MP0005257_abnormal_intraocular_pressure1.62925219
41MP0002233_abnormal_nose_morphology1.61148908
42MP0000647_abnormal_sebaceous_gland1.61020759
43MP0001346_abnormal_lacrimal_gland1.60419417
44MP0001697_abnormal_embryo_size1.60132100
45MP0003950_abnormal_plasma_membrane1.57674103
46MP0002877_abnormal_melanocyte_morpholog1.54524860
47MP0000049_abnormal_middle_ear1.52967657
48MP0009672_abnormal_birth_weight1.52112168
49MP0002009_preneoplasia1.48467592
50MP0003705_abnormal_hypodermis_morpholog1.47412558
51MP0002932_abnormal_joint_morphology1.46700112
52MP0002006_tumorigenesis1.45687685
53MP0002080_prenatal_lethality1.44742318
54MP0000377_abnormal_hair_follicle1.44703457
55MP0000579_abnormal_nail_morphology1.42125466
56MP0000537_abnormal_urethra_morphology1.40367254
57MP0003121_genomic_imprinting1.39235458
58MP0010352_gastrointestinal_tract_polyps1.38703599
59MP0000490_abnormal_crypts_of1.37849674
60MP0002092_abnormal_eye_morphology1.37780011
61MP0009697_abnormal_copulation1.35803837
62MP0004197_abnormal_fetal_growth/weight/1.35162779
63MP0003183_abnormal_peptide_metabolism1.31683445
64MP0003755_abnormal_palate_morphology1.30344949
65MP0005248_abnormal_Harderian_gland1.30039714
66MP0001293_anophthalmia1.29008692
67MP0002653_abnormal_ependyma_morphology1.24926024
68MP0004885_abnormal_endolymph1.20851340
69MP0004808_abnormal_hematopoietic_stem1.20237281
70MP0003937_abnormal_limbs/digits/tail_de1.19322068
71MP0008961_abnormal_basal_metabolism1.18280559
72MP0005174_abnormal_tail_pigmentation1.18051217
73MP0000432_abnormal_head_morphology1.16761138
74MP0003453_abnormal_keratinocyte_physiol1.15910173
75MP0002396_abnormal_hematopoietic_system1.13528855
76MP0000313_abnormal_cell_death1.10808239
77MP0003448_altered_tumor_morphology1.08023122
78MP0005621_abnormal_cell_physiology1.07496739
79MP0003935_abnormal_craniofacial_develop1.05831677
80MP0003091_abnormal_cell_migration1.03383726
81MP0002019_abnormal_tumor_incidence1.02601234
82MP0004233_abnormal_muscle_weight1.02434014
83MP0006035_abnormal_mitochondrial_morpho1.02150181
84MP0002127_abnormal_cardiovascular_syste1.01613656
85MP0006082_CNS_inflammation1.00782216
86MP0000428_abnormal_craniofacial_morphol1.00386783
87MP0003045_fibrosis1.00216062
88MP0002697_abnormal_eye_size1.00180010
89MP0000920_abnormal_myelination0.99722280
90MP0005501_abnormal_skin_physiology0.99390948
91MP0002114_abnormal_axial_skeleton0.98446653
92MP0004272_abnormal_basement_membrane0.97705974
93MP0003315_abnormal_perineum_morphology0.96365017
94MP0002249_abnormal_larynx_morphology0.94835227
95MP0001661_extended_life_span0.94659668
96MP0000467_abnormal_esophagus_morphology0.94313069
97MP0001188_hyperpigmentation0.94287890
98MP0002060_abnormal_skin_morphology0.93893610
99MP0001672_abnormal_embryogenesis/_devel0.93892673
100MP0005380_embryogenesis_phenotype0.93892673
101MP0002166_altered_tumor_susceptibility0.93769715
102MP0001915_intracranial_hemorrhage0.93733193
103MP0000613_abnormal_salivary_gland0.92607441
104MP0003806_abnormal_nucleotide_metabolis0.92401959
105MP0005666_abnormal_adipose_tissue0.92256642
106MP0005310_abnormal_salivary_gland0.92195410
107MP0004133_heterotaxia0.91177730
108MP0004043_abnormal_pH_regulation0.90936700
109MP0009703_decreased_birth_body0.88124084
110MP0003137_abnormal_impulse_conducting0.88062166
111MP0005508_abnormal_skeleton_morphology0.88045144
112MP0000858_altered_metastatic_potential0.87758141
113MP0005391_vision/eye_phenotype0.85769612
114MP0002088_abnormal_embryonic_growth/wei0.85255875
115MP0001216_abnormal_epidermal_layer0.84261435
116MP0005384_cellular_phenotype0.83389889
117MP0003984_embryonic_growth_retardation0.82205457
118MP0002116_abnormal_craniofacial_bone0.81550850
119MP0005395_other_phenotype0.80645475
120MP0008877_abnormal_DNA_methylation0.80362358
121MP0009333_abnormal_splenocyte_physiolog0.80220342
122MP0005623_abnormal_meninges_morphology0.79676489
123MP0000778_abnormal_nervous_system0.79583565
124MP0004947_skin_inflammation0.79430647
125MP0005083_abnormal_biliary_tract0.79249153
126MP0000358_abnormal_cell_content/0.78871714
127MP0003221_abnormal_cardiomyocyte_apopto0.78480864
128MP0000477_abnormal_intestine_morphology0.78016437
129MP0009250_abnormal_appendicular_skeleto0.77230951
130MP0001191_abnormal_skin_condition0.77167911
131MP0003763_abnormal_thymus_physiology0.77142398
132MP0000427_abnormal_hair_cycle0.76995905
133MP0002085_abnormal_embryonic_tissue0.73964405
134MP0003136_yellow_coat_color0.73783369
135MP0002751_abnormal_autonomic_nervous0.73196854
136MP0010771_integument_phenotype0.71201106
137MP0000627_abnormal_mammary_gland0.70117448
138MP0003119_abnormal_digestive_system0.68811806
139MP0002752_abnormal_somatic_nervous0.67878578
140MP0000462_abnormal_digestive_system0.67540327
141MP0008770_decreased_survivor_rate0.67246051
142MP0005023_abnormal_wound_healing0.67138922
143MP0002925_abnormal_cardiovascular_devel0.64778757
144MP0001486_abnormal_startle_reflex0.64171382
145MP0004957_abnormal_blastocyst_morpholog0.62787618
146MP0005409_darkened_coat_color0.62215248
147MP0009278_abnormal_bone_marrow0.61746727
148MP0002084_abnormal_developmental_patter0.61516908
149MP0002086_abnormal_extraembryonic_tissu0.59616504
150MP0001270_distended_abdomen0.59603015
151MP0004782_abnormal_surfactant_physiolog0.59591298
152MP0004185_abnormal_adipocyte_glucose0.58865206
153MP0005275_abnormal_skin_tensile0.58848345
154MP0003828_pulmonary_edema0.58280615
155MP0003699_abnormal_female_reproductive0.58192533
156MP0002081_perinatal_lethality0.57794329
157MP0005197_abnormal_uvea_morphology0.55965966
158MP0002111_abnormal_tail_morphology0.55813336
159MP0000350_abnormal_cell_proliferation0.55812896
160MP0003861_abnormal_nervous_system0.55735743

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)7.24616763
2Hypochromic microcytic anemia (HP:0004840)5.67469876
3Hepatoblastoma (HP:0002884)5.19807945
4Poikiloderma (HP:0001029)4.62807238
5Abnormality of the intrinsic pathway (HP:0010989)4.07900768
6Rib fusion (HP:0000902)4.04888900
7Sensory axonal neuropathy (HP:0003390)3.58639502
8Ependymoma (HP:0002888)3.57806404
9Abnormality of the salivary glands (HP:0010286)3.54454203
10Hypoplasia of the fovea (HP:0007750)3.53722223
11Aplasia/Hypoplasia of the fovea (HP:0008060)3.53722223
12Nasolacrimal duct obstruction (HP:0000579)3.53205525
13Preauricular pit (HP:0004467)3.48849124
14Periauricular skin pits (HP:0100277)3.48849124
15Abnormality of the astrocytes (HP:0100707)3.46591803
16Astrocytoma (HP:0009592)3.46591803
17Anomalous pulmonary venous return (HP:0010772)3.44961722
18Abnormality of the lower motor neuron (HP:0002366)3.42139654
19Partial duplication of thumb phalanx (HP:0009944)3.40808848
20Birth length less than 3rd percentile (HP:0003561)3.40019850
21Multiple enchondromatosis (HP:0005701)3.38209967
22Neoplasm of striated muscle (HP:0009728)3.33985385
23Reduced antithrombin III activity (HP:0001976)3.17386072
24Fused cervical vertebrae (HP:0002949)3.17215303
25Gastrointestinal carcinoma (HP:0002672)3.09229649
26Malignant gastrointestinal tract tumors (HP:0006749)3.09229649
27Rectovaginal fistula (HP:0000143)2.98460440
28Rectal fistula (HP:0100590)2.98460440
29Rhabdomyosarcoma (HP:0002859)2.97869798
30Selective tooth agenesis (HP:0001592)2.95652689
31Abnormality of the pulmonary veins (HP:0011718)2.91670870
32Partial duplication of the phalanx of hand (HP:0009999)2.90129364
33Absent radius (HP:0003974)2.90053231
34Skin pits (HP:0100276)2.87995031
35Bifid tongue (HP:0010297)2.84780247
36Nephroblastoma (Wilms tumor) (HP:0002667)2.82382017
37Capillary hemangiomas (HP:0005306)2.81942294
38Lip pit (HP:0100267)2.81813882
39Ankyloglossia (HP:0010296)2.80253385
40Biliary tract neoplasm (HP:0100574)2.79817062
41Spastic diplegia (HP:0001264)2.79638854
42Intestinal fistula (HP:0100819)2.78828129
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.77014158
44Dyschromatopsia (HP:0007641)2.73756809
45Progressive external ophthalmoplegia (HP:0000590)2.71753134
46Abnormality of the lacrimal duct (HP:0011481)2.71581855
47Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.71358163
48Villous atrophy (HP:0011473)2.63428534
49Abnormality of small intestinal villus morphology (HP:0011472)2.63428534
50Aplasia involving forearm bones (HP:0009822)2.63150992
51Absent forearm bone (HP:0003953)2.63150992
52Abnormality of the fovea (HP:0000493)2.63147854
53Abnormality of the corticospinal tract (HP:0002492)2.62789744
54Large earlobe (HP:0009748)2.61742624
55Embryonal renal neoplasm (HP:0011794)2.60496867
56Squamous cell carcinoma (HP:0002860)2.60063422
57Vaginal fistula (HP:0004320)2.55296495
58Glioma (HP:0009733)2.49587145
59Ulnar bowing (HP:0003031)2.47714953
60Abnormality of oral frenula (HP:0000190)2.47034399
61Basal cell carcinoma (HP:0002671)2.46778609
62Abnormality of the preputium (HP:0100587)2.46328732
63Uterine neoplasm (HP:0010784)2.45740181
64Deviation of the thumb (HP:0009603)2.45705236
65Preauricular skin tag (HP:0000384)2.45112291
66Aplasia/Hypoplasia of the macula (HP:0008059)2.41833556
67Abnormality of the distal phalanx of the thumb (HP:0009617)2.41562453
68Uterine leiomyosarcoma (HP:0002891)2.39798649
69Leiomyosarcoma (HP:0100243)2.39798649
70Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.38956430
71Short humerus (HP:0005792)2.38878102
72Abnormality of chromosome stability (HP:0003220)2.37828310
73Generalized hypotonia (HP:0001290)2.36702436
74Transitional cell carcinoma of the bladder (HP:0006740)2.36472405
75Abnormality of chromosome segregation (HP:0002916)2.36176484
76Difficulty running (HP:0009046)2.35875698
77Type I transferrin isoform profile (HP:0003642)2.35540216
78Abnormality of the pubic bones (HP:0003172)2.34393101
79Aplasia/hypoplasia of the humerus (HP:0006507)2.31409914
80Trismus (HP:0000211)2.30841693
81Skull defect (HP:0001362)2.30693753
82Abnormal lung lobation (HP:0002101)2.30667806
83Abnormality of the nasolacrimal system (HP:0000614)2.29336275
84Testicular atrophy (HP:0000029)2.29108675
85Aplasia/Hypoplasia affecting the retina (HP:0008061)2.28260005
86Turricephaly (HP:0000262)2.28024561
87Hyperventilation (HP:0002883)2.27490373
88Neoplasm of the heart (HP:0100544)2.27241646
89Amyotrophic lateral sclerosis (HP:0007354)2.22801152
90Abnormal auditory evoked potentials (HP:0006958)2.20213046
91Choanal stenosis (HP:0000452)2.19439977
92Upper limb muscle weakness (HP:0003484)2.18767539
93Chromsome breakage (HP:0040012)2.18553063
94Abnormality of the phalanges of the hallux (HP:0010057)2.18479699
95Stenosis of the external auditory canal (HP:0000402)2.17650453
96Skin tags (HP:0010609)2.17099403
97Abnormality of cochlea (HP:0000375)2.16807630
98Short chin (HP:0000331)2.16142179
99Prominent occiput (HP:0000269)2.14438651
100IgA deficiency (HP:0002720)2.13766392
101Horizontal nystagmus (HP:0000666)2.13495414
102Bladder carcinoma (HP:0002862)2.10907360
103Bladder neoplasm (HP:0009725)2.10907360
104Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.10220808
105Difficulty walking (HP:0002355)2.09128304
106Curly hair (HP:0002212)2.07859019
107Hyperinsulinemic hypoglycemia (HP:0000825)2.06370282
108Hypopigmentation of the fundus (HP:0007894)2.05337615
109Progressive muscle weakness (HP:0003323)2.04095024
110Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.03879919
111Abnormal protein N-linked glycosylation (HP:0012347)2.03879919
112Abnormal protein glycosylation (HP:0012346)2.03879919
113Abnormal glycosylation (HP:0012345)2.03879919
114Abnormality of the musculature of the hand (HP:0001421)2.02925593
115Aplasia/Hypoplasia of the scapulae (HP:0006713)2.02191844
116Hypoplastic scapulae (HP:0000882)2.02191844
117Increased nuchal translucency (HP:0010880)2.02032926
118Proximal placement of thumb (HP:0009623)1.99325801
119Neoplasm of the small intestine (HP:0100833)1.97214812
120Spastic tetraparesis (HP:0001285)1.96494327
121Morphological abnormality of the inner ear (HP:0011390)1.96439881
122Hypoplasia of the pons (HP:0012110)1.96294862
123Myelodysplasia (HP:0002863)1.95874686
124Supernumerary nipples (HP:0002558)1.95597221
125Deep philtrum (HP:0002002)1.95505523
126Entropion (HP:0000621)1.95024847
127Neoplasm of the colon (HP:0100273)1.93776065
128Prominent nose (HP:0000448)1.91379748
129Duplication of thumb phalanx (HP:0009942)1.90143657
130Hypotrichosis (HP:0001006)1.90115328
131Facial hemangioma (HP:0000329)1.90060020
132Wide nose (HP:0000445)1.89867982
133Osteolytic defects of the phalanges of the hand (HP:0009771)1.89351465
134Osteolytic defects of the hand bones (HP:0009699)1.89351465
135Tracheal stenosis (HP:0002777)1.88556099
136Broad face (HP:0000283)1.87343424
137Vertebral fusion (HP:0002948)1.86881438
138Supernumerary ribs (HP:0005815)1.86334708
139Open mouth (HP:0000194)1.85252135
140Premature loss of primary teeth (HP:0006323)1.84660551
141Breast aplasia (HP:0100783)1.84257361
142Shawl scrotum (HP:0000049)1.83831965
143Aplasia cutis congenita (HP:0001057)1.83579152
144Breast hypoplasia (HP:0003187)1.83088378
145Short 5th finger (HP:0009237)1.82876074
146Preaxial foot polydactyly (HP:0001841)1.82420915
147Abnormality of nail color (HP:0100643)1.82137866
148Ragged-red muscle fibers (HP:0003200)1.82086023
149Abnormal biliary tract morphology (HP:0012440)1.81887040
150Meckel diverticulum (HP:0002245)1.80002673
151Abnormality of the pons (HP:0007361)1.79686787
152Neoplasm of the rectum (HP:0100743)1.79131986
153Colon cancer (HP:0003003)1.78733290
154Tongue fasciculations (HP:0001308)1.78471084
155Amniotic constriction ring (HP:0009775)1.78290258
156Abnormality of placental membranes (HP:0011409)1.78290258
157Malignant neoplasm of the central nervous system (HP:0100836)1.78075264
158Right ventricular cardiomyopathy (HP:0011663)1.77975911
159Periodontitis (HP:0000704)1.77810382
160Acute myeloid leukemia (HP:0004808)1.77801560
161Small intestinal stenosis (HP:0012848)1.77308526
162Duodenal stenosis (HP:0100867)1.77308526
163Abnormal cartilage morphology (HP:0002763)1.76957132
164Neoplasm of the oral cavity (HP:0100649)1.76784005
165Abnormality of homocysteine metabolism (HP:0010919)1.75671111
166Homocystinuria (HP:0002156)1.75671111
167Glossoptosis (HP:0000162)1.75495734
168Ventricular tachycardia (HP:0004756)1.74404167
169Subacute progressive viral hepatitis (HP:0006572)1.74386319
170Neoplasm of the pancreas (HP:0002894)1.73860850
171Cheilitis (HP:0100825)1.73474626
172Mildly elevated creatine phosphokinase (HP:0008180)1.73403750
173Coronal craniosynostosis (HP:0004440)1.72064544
174Diastasis recti (HP:0001540)1.72063663
175Pseudobulbar signs (HP:0002200)1.71469178
176Tented upper lip vermilion (HP:0010804)1.70716289
177Aplasia/Hypoplasia of the breasts (HP:0010311)1.70125541
178Abnormality of glycolipid metabolism (HP:0010969)1.69652669
179Abnormality of glycosphingolipid metabolism (HP:0004343)1.69652669
180Abnormality of the common coagulation pathway (HP:0010990)1.69228656
181Renal cell carcinoma (HP:0005584)1.68345954

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.56879207
2GRK54.89156035
3ERN13.62391320
4GRK63.43737482
5GRK13.01178222
6MST1R2.96974764
7TYRO32.87062914
8ADRBK22.78211781
9PBK2.76678448
10BUB12.70963064
11WNK12.50361263
12GRK72.48736719
13SMG12.46760893
14CSF1R2.45305399
15BRD42.40622564
16ERBB42.39360873
17CDC72.37292316
18EPHA22.36481047
19BRSK22.27709522
20TGFBR22.21166825
21TSSK62.13315224
22MAPK72.11809463
23MKNK22.03010167
24NTRK12.02639776
25TAF11.98124703
26MATK1.94700638
27EPHB11.81018012
28ACVR1B1.80655603
29STK101.78803717
30MOS1.73851998
31LATS11.71683563
32SRPK11.71469152
33MARK21.69457714
34STK391.66809268
35TTK1.60302998
36STK31.55382917
37NME21.52188095
38STK38L1.47625237
39PLK31.44509112
40MKNK11.42398742
41EIF2AK31.33455701
42MELK1.33101297
43CAMK41.32564768
44FGFR41.30459527
45PRPF4B1.30159214
46SCYL21.29960532
47HIPK21.29142931
48PLK41.25974876
49IRAK31.25627677
50FGFR31.23996049
51PRKG21.23150049
52WEE11.22764590
53BCR1.21314058
54NEK21.16845283
55CDK61.14388245
56MAP3K141.14269250
57STK241.13052393
58MST41.10347175
59VRK21.09215602
60TRIM281.08922341
61ZAK1.07946050
62PKN11.05088629
63ADRBK11.04927827
64CAMK1D1.00155475
65BMX0.97762272
66PDGFRA0.97574066
67CDK40.96436964
68FGFR10.91076221
69TTN0.89458675
70MAP3K70.89377917
71ATR0.86202759
72PTK20.85980450
73CDK70.83673927
74DDR20.82257536
75PAK40.81923198
76OXSR10.81806074
77CDK90.81691769
78MAP3K90.81649002
79ERBB20.80876872
80PDK20.79564374
81AURKB0.78812026
82EEF2K0.76626455
83CDK80.76144611
84STK40.74299588
85PAK30.73624424
86EIF2AK10.73028718
87CHEK20.71170965
88ATM0.70290270
89MAP3K130.67919440
90MAPK120.66231471
91AKT30.65693522
92CSNK1A1L0.65238333
93YES10.64205099
94CSK0.64165086
95NEK10.63002443
96DYRK20.62519723
97NUAK10.62111461
98MAP3K80.61699462
99LMTK20.61047457
100EIF2AK20.59277019
101RPS6KB20.59013318
102MAPKAPK30.58708110
103BRSK10.57633186
104VRK10.56896989
105PAK60.56702844
106MAP2K40.56386056
107MET0.55164679
108SIK30.54312469
109AKT20.53308123
110SIK10.52645916
111PIM10.51369362
112IRAK20.50652824
113CLK10.50412305
114MTOR0.50022972
115FLT30.48757688
116NLK0.48460918
117DMPK0.47019383
118CDK10.46429696
119ITK0.46385834
120FGFR20.46137698
121ALK0.45745010
122TIE10.45339182
123CDK20.44959380
124MAP2K60.44262660
125GSK3A0.43609220
126CSNK1G30.42548417
127FER0.42281843
128DYRK1A0.41927901
129ICK0.41587115
130TGFBR10.40948850
131EPHA30.40649535
132CHUK0.40271312
133PRKCI0.38623056
134INSR0.38181362
135CHEK10.37934043
136IGF1R0.35924807
137MAP3K100.35246078
138IKBKB0.34608491
139EPHB20.33793828
140MAPK100.33314626
141LATS20.33182284
142MAP2K30.32741611
143EGFR0.31704732
144CSNK1E0.31588319
145TESK20.31579371
146NEK60.31537335
147AURKA0.31021561
148JAK30.30833832
149DYRK30.30761012
150CAMK1G0.30485006
151UHMK10.30448617
152TRPM70.30180017
153RIPK10.29562333
154CSNK1D0.27999046
155CSNK1G20.27640396
156PRKACB0.27198538
157MAPKAPK20.27013607
158MAPKAPK50.26380839
159CSNK1G10.26332377
160GSK3B0.24056835
161PRKD10.23702818
162PRKCD0.22481420
163NTRK20.22246963
164PRKD20.22077018
165PLK10.21509781
166MAPK10.20305287
167ROCK20.20254623
168MARK10.19877447
169WNK40.19398542
170DYRK1B0.19132555

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.97566300
2Vitamin B6 metabolism_Homo sapiens_hsa007505.67279328
3DNA replication_Homo sapiens_hsa030303.14810476
4Arachidonic acid metabolism_Homo sapiens_hsa005902.87382275
5Mismatch repair_Homo sapiens_hsa034302.78615639
6Non-homologous end-joining_Homo sapiens_hsa034502.76228314
7Linoleic acid metabolism_Homo sapiens_hsa005912.69300818
8Cell cycle_Homo sapiens_hsa041102.68294765
9alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.67504280
10Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.55949248
11RNA transport_Homo sapiens_hsa030132.35971438
12Ether lipid metabolism_Homo sapiens_hsa005652.25122552
13Selenocompound metabolism_Homo sapiens_hsa004502.18905733
14Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.15192272
15Fructose and mannose metabolism_Homo sapiens_hsa000512.07654341
16Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.92342536
17Basal cell carcinoma_Homo sapiens_hsa052171.91146926
18Nucleotide excision repair_Homo sapiens_hsa034201.82575225
19p53 signaling pathway_Homo sapiens_hsa041151.79333858
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.73150268
21Spliceosome_Homo sapiens_hsa030401.71321478
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.66656927
23Fanconi anemia pathway_Homo sapiens_hsa034601.65338819
24Basal transcription factors_Homo sapiens_hsa030221.54820468
25Homologous recombination_Homo sapiens_hsa034401.54758098
26Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.53087869
27One carbon pool by folate_Homo sapiens_hsa006701.51099606
28Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.50488699
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.50310853
30Axon guidance_Homo sapiens_hsa043601.50014056
31N-Glycan biosynthesis_Homo sapiens_hsa005101.47302642
32Base excision repair_Homo sapiens_hsa034101.45475168
33Hippo signaling pathway_Homo sapiens_hsa043901.41159088
34Tight junction_Homo sapiens_hsa045301.37250397
35Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.36618266
36Hedgehog signaling pathway_Homo sapiens_hsa043401.36507401
37RNA degradation_Homo sapiens_hsa030181.34916118
38Proteasome_Homo sapiens_hsa030501.32359713
39Regulation of actin cytoskeleton_Homo sapiens_hsa048101.31814658
40Phospholipase D signaling pathway_Homo sapiens_hsa040721.31749057
41Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.31489579
42Cysteine and methionine metabolism_Homo sapiens_hsa002701.31269151
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.27330127
44Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.25633030
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25285315
46Ovarian steroidogenesis_Homo sapiens_hsa049131.24566285
47Biosynthesis of amino acids_Homo sapiens_hsa012301.23335746
48mTOR signaling pathway_Homo sapiens_hsa041501.15549083
49Viral carcinogenesis_Homo sapiens_hsa052031.14190862
50RNA polymerase_Homo sapiens_hsa030201.13081480
51Pathways in cancer_Homo sapiens_hsa052001.11801114
52Wnt signaling pathway_Homo sapiens_hsa043101.10932381
53Transcriptional misregulation in cancer_Homo sapiens_hsa052021.10829656
54Choline metabolism in cancer_Homo sapiens_hsa052311.10015692
55Chronic myeloid leukemia_Homo sapiens_hsa052201.09272778
56Central carbon metabolism in cancer_Homo sapiens_hsa052301.09254023
57Inositol phosphate metabolism_Homo sapiens_hsa005621.08496280
58Pyrimidine metabolism_Homo sapiens_hsa002401.07244947
59Steroid biosynthesis_Homo sapiens_hsa001001.06171325
60MicroRNAs in cancer_Homo sapiens_hsa052061.05397934
61Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.04588450
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.04327642
63Thyroid cancer_Homo sapiens_hsa052161.02550611
64Galactose metabolism_Homo sapiens_hsa000521.00693012
65Vitamin digestion and absorption_Homo sapiens_hsa049770.98021011
66Lysine degradation_Homo sapiens_hsa003100.97096538
67Herpes simplex infection_Homo sapiens_hsa051680.96150361
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.95184795
69Rap1 signaling pathway_Homo sapiens_hsa040150.93866085
70Chemical carcinogenesis_Homo sapiens_hsa052040.93662997
71Adherens junction_Homo sapiens_hsa045200.93393693
72Pentose and glucuronate interconversions_Homo sapiens_hsa000400.92836288
73Apoptosis_Homo sapiens_hsa042100.92281351
74Serotonergic synapse_Homo sapiens_hsa047260.92089543
75Taste transduction_Homo sapiens_hsa047420.90960689
76ECM-receptor interaction_Homo sapiens_hsa045120.90909871
77Notch signaling pathway_Homo sapiens_hsa043300.90451743
78Ras signaling pathway_Homo sapiens_hsa040140.89890706
79Pentose phosphate pathway_Homo sapiens_hsa000300.89276376
80Proteoglycans in cancer_Homo sapiens_hsa052050.87220896
81Dorso-ventral axis formation_Homo sapiens_hsa043200.86834705
82Glutamatergic synapse_Homo sapiens_hsa047240.86098927
83Leukocyte transendothelial migration_Homo sapiens_hsa046700.85403265
84Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.84258777
85Systemic lupus erythematosus_Homo sapiens_hsa053220.82324063
86Epstein-Barr virus infection_Homo sapiens_hsa051690.79800846
87Prostate cancer_Homo sapiens_hsa052150.79738755
88Influenza A_Homo sapiens_hsa051640.75837240
89Sphingolipid signaling pathway_Homo sapiens_hsa040710.75237678
90Measles_Homo sapiens_hsa051620.75073632
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.75002959
92Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73953943
93Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.72969434
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71026550
95Vascular smooth muscle contraction_Homo sapiens_hsa042700.70627252
96RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.70453683
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.70219425
98African trypanosomiasis_Homo sapiens_hsa051430.69035336
99Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68927047
100Pancreatic cancer_Homo sapiens_hsa052120.68843619
101Other glycan degradation_Homo sapiens_hsa005110.68267761
102HTLV-I infection_Homo sapiens_hsa051660.65396281
103Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63733280
104Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62920585
105Hepatitis B_Homo sapiens_hsa051610.62887899
106Shigellosis_Homo sapiens_hsa051310.62784325
107Bladder cancer_Homo sapiens_hsa052190.62737317
108Long-term depression_Homo sapiens_hsa047300.61647641
109Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60522764
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60169131
111GABAergic synapse_Homo sapiens_hsa047270.59934479
112cAMP signaling pathway_Homo sapiens_hsa040240.58773270
113Dilated cardiomyopathy_Homo sapiens_hsa054140.58548012
114PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58347217
115Sphingolipid metabolism_Homo sapiens_hsa006000.57571395
116Sulfur relay system_Homo sapiens_hsa041220.56444711
117ErbB signaling pathway_Homo sapiens_hsa040120.56192421
118Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.55660328
119MAPK signaling pathway_Homo sapiens_hsa040100.55339075
120Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.54313296
121Oocyte meiosis_Homo sapiens_hsa041140.53388932
122Purine metabolism_Homo sapiens_hsa002300.52429464
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52084528
124Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52072934
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.51139222
126Focal adhesion_Homo sapiens_hsa045100.50988398
127Protein digestion and absorption_Homo sapiens_hsa049740.50345393
128Small cell lung cancer_Homo sapiens_hsa052220.50244997
129Glycosaminoglycan degradation_Homo sapiens_hsa005310.49910907
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.49375786
131Fatty acid elongation_Homo sapiens_hsa000620.48659280
132Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48510714
133VEGF signaling pathway_Homo sapiens_hsa043700.47743657
134Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.47429783
135Acute myeloid leukemia_Homo sapiens_hsa052210.46501425
136Renal cell carcinoma_Homo sapiens_hsa052110.46384981
137Histidine metabolism_Homo sapiens_hsa003400.45845423
138GnRH signaling pathway_Homo sapiens_hsa049120.45688490
139NF-kappa B signaling pathway_Homo sapiens_hsa040640.44869854
140Hepatitis C_Homo sapiens_hsa051600.43422061
141Melanogenesis_Homo sapiens_hsa049160.41858172
142NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41382400
143Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.39846034
144Legionellosis_Homo sapiens_hsa051340.39065286
145TNF signaling pathway_Homo sapiens_hsa046680.38439681
146Carbon metabolism_Homo sapiens_hsa012000.37160180
147Endometrial cancer_Homo sapiens_hsa052130.37128952
148TGF-beta signaling pathway_Homo sapiens_hsa043500.36925923
149Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.36643361
150Toxoplasmosis_Homo sapiens_hsa051450.36624897
151Colorectal cancer_Homo sapiens_hsa052100.35775213
152Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.35575312
1532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35448471
154mRNA surveillance pathway_Homo sapiens_hsa030150.33730709
155Regulation of autophagy_Homo sapiens_hsa041400.33326378
156Non-small cell lung cancer_Homo sapiens_hsa052230.33123228
157Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32996996
158Renin-angiotensin system_Homo sapiens_hsa046140.32944441
159Endocytosis_Homo sapiens_hsa041440.32747587
160Salivary secretion_Homo sapiens_hsa049700.32354307
161Retinol metabolism_Homo sapiens_hsa008300.32163650
162Melanoma_Homo sapiens_hsa052180.30354366

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