ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	water-soluble vitamin biosynthetic process (GO:0042364)	6.63878687
2	positive regulation of chemokine secretion (GO:0090197)	5.79072648
3	regulation of chemokine secretion (GO:0090196)	5.01115780
4	dopamine transport (GO:0015872)	4.95356294
5	regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:1902235	4.76284675
6	glycerophospholipid catabolic process (GO:0046475)	4.55752758
7	positive regulation of macrophage activation (GO:0043032)	4.51075452
8	cellular response to follicle-stimulating hormone stimulus (GO:0071372)	4.43486650
9	regulation of gonadotropin secretion (GO:0032276)	4.27766312
10	astrocyte differentiation (GO:0048708)	4.20278051
11	endocrine hormone secretion (GO:0060986)	4.14461024
12	axoneme assembly (GO:0035082)	4.11456224
13	lactate metabolic process (GO:0006089)	4.05131778
14	aldehyde catabolic process (GO:0046185)	3.99408425
15	L-ascorbic acid metabolic process (GO:0019852)	3.98518817
16	regulation of cytokine production involved in inflammatory response (GO:1900015)	3.84922241
17	ubiquinone metabolic process (GO:0006743)	3.82233818
18	positive regulation of mitotic metaphase/anaphase transition (GO:0045842)	3.77003708
19	positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)	3.77003708
20	positive regulation of mitotic sister chromatid separation (GO:1901970)	3.77003708
21	epithelial cell fate commitment (GO:0072148)	3.63225179
22	negative regulation of macrophage differentiation (GO:0045650)	3.59657813
23	cell wall macromolecule catabolic process (GO:0016998)	3.58301651
24	early endosome to late endosome transport (GO:0045022)	3.56796401
25	photoreceptor cell differentiation (GO:0046530)	3.49507902
26	eye photoreceptor cell differentiation (GO:0001754)	3.49507902
27	kidney morphogenesis (GO:0060993)	3.46578503
28	nonmotile primary cilium assembly (GO:0035058)	3.45518887
29	insulin secretion (GO:0030073)	3.38137776
30	ubiquinone biosynthetic process (GO:0006744)	3.37079148
31	cellular ketone body metabolic process (GO:0046950)	3.32294481
32	catecholamine transport (GO:0051937)	3.31317692
33	regulation of interleukin-5 production (GO:0032674)	3.28688948
34	indolalkylamine metabolic process (GO:0006586)	3.26644691
35	estrogen biosynthetic process (GO:0006703)	3.23856208
36	cell wall macromolecule metabolic process (GO:0044036)	3.21048866
37	vitamin biosynthetic process (GO:0009110)	3.20345545
38	triglyceride homeostasis (GO:0070328)	3.13729670
39	acylglycerol homeostasis (GO:0055090)	3.13729670
40	response to follicle-stimulating hormone (GO:0032354)	3.13437411
41	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	3.11524141
42	DNA damage induced protein phosphorylation (GO:0006975)	3.08798525
43	dorsal/ventral axis specification (GO:0009950)	3.06002116
44	UDP-N-acetylglucosamine metabolic process (GO:0006047)	3.04760924
45	regulation of acrosome reaction (GO:0060046)	3.04473441
46	Golgi to endosome transport (GO:0006895)	3.04425918
47	L-fucose catabolic process (GO:0042355)	3.03549237
48	fucose catabolic process (GO:0019317)	3.03549237
49	L-fucose metabolic process (GO:0042354)	3.03549237
50	behavioral response to nicotine (GO:0035095)	3.03406629
51	regulation of glucocorticoid secretion (GO:2000849)	3.02238556
52	photoreceptor cell maintenance (GO:0045494)	2.99863113
53	ketone body metabolic process (GO:1902224)	2.98312801
54	nephron epithelium morphogenesis (GO:0072088)	2.94889591
55	nephron tubule morphogenesis (GO:0072078)	2.94889591
56	retinal rod cell development (GO:0046548)	2.94244410
57	protein-chromophore linkage (GO:0018298)	2.84853838
58	cellular biogenic amine catabolic process (GO:0042402)	2.84648462
59	amine catabolic process (GO:0009310)	2.84648462
60	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.83967115
61	negative regulation of neurotransmitter transport (GO:0051589)	2.83518988
62	epithelial cilium movement (GO:0003351)	2.80464691
63	regulation of hexokinase activity (GO:1903299)	2.80370732
64	regulation of glucokinase activity (GO:0033131)	2.80370732
65	negative regulation of complement activation (GO:0045916)	2.78641902
66	brain morphogenesis (GO:0048854)	2.76729416
67	negative regulation of protein activation cascade (GO:2000258)	2.75988983
68	quinone metabolic process (GO:1901661)	2.75490881
69	detection of calcium ion (GO:0005513)	2.75087849
70	quinone biosynthetic process (GO:1901663)	2.73202973
71	intra-Golgi vesicle-mediated transport (GO:0006891)	2.73028042
72	establishment of protein localization to Golgi (GO:0072600)	2.72669947
73	cilium movement (GO:0003341)	2.71655997
74	intraciliary transport (GO:0042073)	2.71250980
75	cellular response to sterol (GO:0036315)	2.70100810
76	cornea development in camera-type eye (GO:0061303)	2.68449283
77	phospholipid catabolic process (GO:0009395)	2.68136815
78	positive regulation of actin filament depolymerization (GO:0030836)	2.66282777
79	piRNA metabolic process (GO:0034587)	2.63751923
80	male meiosis (GO:0007140)	2.63710849
81	chemosensory behavior (GO:0007635)	2.63054423
82	regulation of endothelial cell differentiation (GO:0045601)	2.61560845
83	macroautophagy (GO:0016236)	2.59912574
84	regulation of cilium movement (GO:0003352)	2.59577026
85	cellular response to cholesterol (GO:0071397)	2.58984363
86	protein targeting to Golgi (GO:0000042)	2.57591635
87	endocrine pancreas development (GO:0031018)	2.56424627
88	toxin metabolic process (GO:0009404)	2.56421869
89	regulation of macrophage activation (GO:0043030)	2.55049364
90	cilium or flagellum-dependent cell motility (GO:0001539)	2.54045832
91	regulation of ER to Golgi vesicle-mediated transport (GO:0060628)	2.53869156
92	short-chain fatty acid metabolic process (GO:0046459)	2.50756845
93	thyroid hormone metabolic process (GO:0042403)	2.50119366
94	cellular response to gonadotropin stimulus (GO:0071371)	2.49486293
95	negative regulation of circadian rhythm (GO:0042754)	2.49280787
96	uronic acid metabolic process (GO:0006063)	2.44734905
97	glucuronate metabolic process (GO:0019585)	2.44734905
98	alanine transport (GO:0032328)	2.43421784
99	calcium ion import (GO:0070509)	2.43394740
100	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.41542563

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	4.97115409
2	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	3.32212906
3	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	3.30497131
4	ZNF274_21170338_ChIP-Seq_K562_Hela	2.95329069
5	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.65649759
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.53413096
7	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.50779536
8	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.44222790
9	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.29603468
10	VDR_22108803_ChIP-Seq_LS180_Human	2.26790470
11	TAF15_26573619_Chip-Seq_HEK293_Human	2.25439271
12	RBPJ_22232070_ChIP-Seq_NCS_Mouse	2.24689903
13	GBX2_23144817_ChIP-Seq_PC3_Human	2.12770514
14	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.10974350
15	PCGF2_27294783_Chip-Seq_ESCs_Mouse	2.07596556
16	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.89315069
17	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.85995171
18	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.84536146
19	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.84337486
20	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.84264734
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.82998029
22	FUS_26573619_Chip-Seq_HEK293_Human	1.82882716
23	SMAD4_21799915_ChIP-Seq_A2780_Human	1.75309411
24	EWS_26573619_Chip-Seq_HEK293_Human	1.64415860
25	P300_19829295_ChIP-Seq_ESCs_Human	1.60606091
26	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.58712740
27	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.58100473
28	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.55627573
29	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.55199035
30	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.55034745
31	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.54196704
32	STAT3_23295773_ChIP-Seq_U87_Human	1.54140339
33	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.51427641
34	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.49999912
35	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.49830416
36	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.48190455
37	TCF4_23295773_ChIP-Seq_U87_Human	1.45672617
38	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.44868096
39	BCAT_22108803_ChIP-Seq_LS180_Human	1.44613902
40	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.43992590
41	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.42728779
42	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.41861280
43	AR_25329375_ChIP-Seq_VCAP_Human	1.41790510
44	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.41014374
45	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.39870410
46	CBP_20019798_ChIP-Seq_JUKART_Human	1.39870410
47	ELK1_19687146_ChIP-ChIP_HELA_Human	1.38729274
48	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.38159528
49	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.37297971
50	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.37248233
51	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.36328384
52	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.34955438
53	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.33400416
54	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.33242960
55	CDX2_22108803_ChIP-Seq_LS180_Human	1.29841461
56	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.29712782
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.26113728
58	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.23957881
59	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.22982811
60	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.22982811
61	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.22643129
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.22455761
63	NANOG_19829295_ChIP-Seq_ESCs_Human	1.22455761
64	SOX2_18555785_Chip-Seq_ESCs_Mouse	1.22450216
65	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.22075701
66	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.21663254
67	TCF4_22108803_ChIP-Seq_LS180_Human	1.19743410
68	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.19403527
69	CMYC_18555785_Chip-Seq_ESCs_Mouse	1.17791573
70	SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse	1.17518917
71	P53_22387025_ChIP-Seq_ESCs_Mouse	1.15895631
72	RUNX2_22187159_ChIP-Seq_PCA_Human	1.14031093
73	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.13828220
74	TP53_22573176_ChIP-Seq_HFKS_Human	1.13021548
75	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12494424
76	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.12431753
77	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.11767230
78	AR_20517297_ChIP-Seq_VCAP_Human	1.11521541
79	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.10542758
80	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.10348995
81	OCT4_21477851_ChIP-Seq_ESCs_Mouse	1.09778207
82	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	1.09579428
83	NMYC_18555785_Chip-Seq_ESCs_Mouse	1.09044242
84	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.08633660
85	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.07236708
86	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.06943417
87	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.06156342
88	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.05286351
89	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.04289632
90	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.03497010
91	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.03320002
92	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.03292525
93	P300_18555785_Chip-Seq_ESCs_Mouse	1.02991155
94	OCT4_18555785_Chip-Seq_ESCs_Mouse	1.01022742
95	ESR1_21235772_ChIP-Seq_MCF-7_Human	1.01013437
96	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.00925241
97	AHR_22903824_ChIP-Seq_MCF-7_Human	1.00597062
98	CJUN_26792858_Chip-Seq_BT549_Human	0.98173803
99	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.98055389
100	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.97513444

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003787_abnormal_imprinting	4.25652165
2	MP0003195_calcinosis	4.19766904
3	MP0002638_abnormal_pupillary_reflex	4.00127330
4	MP0008877_abnormal_DNA_methylation	3.45585058
5	MP0005187_abnormal_penis_morphology	3.17073824
6	MP0009046_muscle_twitch	2.76689061
7	MP0002837_dystrophic_cardiac_calcinosis	2.71758204
8	MP0006072_abnormal_retinal_apoptosis	2.69526929
9	MP0005670_abnormal_white_adipose	2.67227363
10	MP0002909_abnormal_adrenal_gland	2.59303431
11	MP0009780_abnormal_chondrocyte_physiolo	2.51575106
12	MP0005645_abnormal_hypothalamus_physiol	2.42996648
13	MP0003136_yellow_coat_color	2.36437907
14	MP0005379_endocrine/exocrine_gland_phen	1.99694497
15	MP0005253_abnormal_eye_physiology	1.91928365
16	MP0002876_abnormal_thyroid_physiology	1.90129300
17	MP0002163_abnormal_gland_morphology	1.82431877
18	MP0001944_abnormal_pancreas_morphology	1.75796642
19	MP0003122_maternal_imprinting	1.70968765
20	MP0006276_abnormal_autonomic_nervous	1.69163882
21	MP0010329_abnormal_lipoprotein_level	1.69048136
22	MP0005551_abnormal_eye_electrophysiolog	1.66266502
23	MP0002254_reproductive_system_inflammat	1.65923231
24	MP0003121_genomic_imprinting	1.65460978
25	MP0001501_abnormal_sleep_pattern	1.58203829
26	MP0001986_abnormal_taste_sensitivity	1.57285081
27	MP0001502_abnormal_circadian_rhythm	1.56748700
28	MP0002693_abnormal_pancreas_physiology	1.52385763
29	MP0009745_abnormal_behavioral_response	1.51692787
30	MP0000569_abnormal_digit_pigmentation	1.49953219
31	MP0005646_abnormal_pituitary_gland	1.49519052
32	MP0005085_abnormal_gallbladder_physiolo	1.47201737
33	MP0010234_abnormal_vibrissa_follicle	1.42878355
34	MP0000427_abnormal_hair_cycle	1.42352586
35	MP0002090_abnormal_vision	1.37286025
36	MP0005365_abnormal_bile_salt	1.37191001
37	MP0006292_abnormal_olfactory_placode	1.34609904
38	MP0001970_abnormal_pain_threshold	1.33687917
39	MP0001984_abnormal_olfaction	1.32902080
40	MP0004019_abnormal_vitamin_homeostasis	1.32816773
41	MP0002736_abnormal_nociception_after	1.32758159
42	MP0002139_abnormal_hepatobiliary_system	1.27935151
43	MP0010386_abnormal_urinary_bladder	1.24683484
44	MP0000372_irregular_coat_pigmentation	1.22112408
45	MP0003890_abnormal_embryonic-extraembry	1.19772403
46	MP0001905_abnormal_dopamine_level	1.17603452
47	MP0008872_abnormal_physiological_respon	1.16317209
48	MP0005084_abnormal_gallbladder_morpholo	1.14982679
49	MP0002078_abnormal_glucose_homeostasis	1.13796293
50	MP0001968_abnormal_touch/_nociception	1.12942168
51	MP0005535_abnormal_body_temperature	1.09465742
52	MP0004215_abnormal_myocardial_fiber	1.07433318
53	MP0003123_paternal_imprinting	1.07323599
54	MP0000013_abnormal_adipose_tissue	1.06936553
55	MP0001485_abnormal_pinna_reflex	1.04672216
56	MP0003172_abnormal_lysosome_physiology	1.04335060
57	MP0002733_abnormal_thermal_nociception	1.03529804
58	MP0001299_abnormal_eye_distance/	1.03094404
59	MP0003252_abnormal_bile_duct	1.02722851
60	MP0002734_abnormal_mechanical_nocicepti	1.02350147
61	MP0008995_early_reproductive_senescence	1.02136848
62	MP0004085_abnormal_heartbeat	1.02112359
63	MP0000538_abnormal_urinary_bladder	1.02086507
64	MP0002572_abnormal_emotion/affect_behav	1.01203166
65	MP0002064_seizures	1.00092633
66	MP0003953_abnormal_hormone_level	0.99262038
67	MP0002229_neurodegeneration	0.96112466
68	MP0000516_abnormal_urinary_system	0.96064042
69	MP0005367_renal/urinary_system_phenotyp	0.96064042
70	MP0005332_abnormal_amino_acid	0.96035558
71	MP0003718_maternal_effect	0.94876716
72	MP0004043_abnormal_pH_regulation	0.93103587
73	MP0001661_extended_life_span	0.92264573
74	MP0000647_abnormal_sebaceous_gland	0.91779059
75	MP0001756_abnormal_urination	0.90402081
76	MP0002102_abnormal_ear_morphology	0.90005851
77	MP0000631_abnormal_neuroendocrine_gland	0.89791640
78	MP0002272_abnormal_nervous_system	0.89338854
79	MP0005174_abnormal_tail_pigmentation	0.87669345
80	MP0010352_gastrointestinal_tract_polyps	0.86348424
81	MP0008775_abnormal_heart_ventricle	0.85994095
82	MP0003880_abnormal_central_pattern	0.85843296
83	MP0003868_abnormal_feces_composition	0.84873646
84	MP0000639_abnormal_adrenal_gland	0.84654542
85	MP0003045_fibrosis	0.84314823
86	MP0002557_abnormal_social/conspecific_i	0.84260485
87	MP0002009_preneoplasia	0.84193335
88	MP0002735_abnormal_chemical_nociception	0.82196409
89	MP0010678_abnormal_skin_adnexa	0.82129423
90	MP0002160_abnormal_reproductive_system	0.81942754
91	MP0002928_abnormal_bile_duct	0.81885027
92	MP0002168_other_aberrant_phenotype	0.81398423
93	MP0005195_abnormal_posterior_eye	0.80470387
94	MP0003633_abnormal_nervous_system	0.79974521
95	MP0005395_other_phenotype	0.78591361
96	MP0005220_abnormal_exocrine_pancreas	0.78575915
97	MP0005448_abnormal_energy_balance	0.77621561
98	MP0003300_gastrointestinal_ulcer	0.77055424
99	MP0005408_hypopigmentation	0.76898131
100	MP0005636_abnormal_mineral_homeostasis	0.76159992

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal rod and cone electroretinograms (HP:0008323)	4.01806179
2	Diastasis recti (HP:0001540)	3.95377666
3	Hypothermia (HP:0002045)	3.90618113
4	Hyperventilation (HP:0002883)	3.78581152
5	Intestinal atresia (HP:0011100)	3.46099453
6	Limb dystonia (HP:0002451)	3.42465093
7	Medial flaring of the eyebrow (HP:0010747)	3.38905475
8	Decreased central vision (HP:0007663)	3.36038032
9	Bony spicule pigmentary retinopathy (HP:0007737)	3.21791346
10	Chronic hepatic failure (HP:0100626)	3.16566301
11	Large for gestational age (HP:0001520)	3.04691275
12	Distal arthrogryposis (HP:0005684)	2.91141653
13	Nephronophthisis (HP:0000090)	2.90745097
14	Hemiparesis (HP:0001269)	2.88737094
15	Congenital primary aphakia (HP:0007707)	2.78388200
16	Gait imbalance (HP:0002141)	2.78004419
17	Molar tooth sign on MRI (HP:0002419)	2.76999685
18	Abnormality of midbrain morphology (HP:0002418)	2.76999685
19	Cone-rod dystrophy (HP:0000548)	2.73415134
20	Generalized myoclonic seizures (HP:0002123)	2.72975023
21	Mesangial abnormality (HP:0001966)	2.70087777
22	Nephrogenic diabetes insipidus (HP:0009806)	2.69060985
23	Pancreatic fibrosis (HP:0100732)	2.65811199
24	Hypomagnesemia (HP:0002917)	2.63960832
25	Attenuation of retinal blood vessels (HP:0007843)	2.57855198
26	Absent/shortened dynein arms (HP:0200106)	2.55169613
27	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.55169613
28	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.53105266
29	Abnormality of the renal cortex (HP:0011035)	2.53077034
30	Abolished electroretinogram (ERG) (HP:0000550)	2.51864959
31	Abnormality of the renal medulla (HP:0100957)	2.47820305
32	Progressive macrocephaly (HP:0004481)	2.41480873
33	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.38132432
34	Hypoplasia of the fovea (HP:0007750)	2.38132432
35	Microretrognathia (HP:0000308)	2.36786531
36	Neoplasm of the adrenal cortex (HP:0100641)	2.36584674
37	Renal cortical cysts (HP:0000803)	2.34868295
38	Pancreatic cysts (HP:0001737)	2.28624925
39	Abnormality of vitamin B metabolism (HP:0004340)	2.28348565
40	Bifid tongue (HP:0010297)	2.28100846
41	Difficulty running (HP:0009046)	2.27269615
42	Tubulointerstitial nephritis (HP:0001970)	2.26224953
43	Aqueductal stenosis (HP:0002410)	2.26110091
44	Genital tract atresia (HP:0001827)	2.25720743
45	Polydipsia (HP:0001959)	2.21770005
46	Abnormal drinking behavior (HP:0030082)	2.21770005
47	Follicular hyperkeratosis (HP:0007502)	2.21580130
48	Ketoacidosis (HP:0001993)	2.19306826
49	True hermaphroditism (HP:0010459)	2.15719916
50	Decreased circulating renin level (HP:0003351)	2.14244576
51	Methylmalonic acidemia (HP:0002912)	2.11228301
52	Vaginal atresia (HP:0000148)	2.11067690
53	Abnormality of the fovea (HP:0000493)	2.10830518
54	Abnormality of magnesium homeostasis (HP:0004921)	2.09529431
55	Acute necrotizing encephalopathy (HP:0006965)	2.07864300
56	Hyperinsulinemic hypoglycemia (HP:0000825)	2.06722046
57	Abnormality of calcium-phosphate metabolism (HP:0100530)	2.06419196
58	Abnormal respiratory motile cilium morphology (HP:0005938)	2.05050756
59	Abnormal respiratory epithelium morphology (HP:0012253)	2.05050756
60	Limb hypertonia (HP:0002509)	2.03402707
61	Muscular hypotonia of the trunk (HP:0008936)	2.00020223
62	Acute encephalopathy (HP:0006846)	1.99716047
63	Type II lissencephaly (HP:0007260)	1.98297127
64	Pendular nystagmus (HP:0012043)	1.98109508
65	Abnormal protein glycosylation (HP:0012346)	1.97944618
66	Abnormal glycosylation (HP:0012345)	1.97944618
67	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.97944618
68	Abnormal protein N-linked glycosylation (HP:0012347)	1.97944618
69	Abnormality of aspartate family amino acid metabolism (HP:0010899)	1.97772674
70	Increased corneal curvature (HP:0100692)	1.96421460
71	Keratoconus (HP:0000563)	1.96421460
72	Enlarged penis (HP:0000040)	1.95980337
73	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.95514136
74	Hyperglycemia (HP:0003074)	1.94939559
75	Tubular atrophy (HP:0000092)	1.93013008
76	Neoplasm of the adrenal gland (HP:0100631)	1.93004900
77	Concave nail (HP:0001598)	1.91715598
78	Poor coordination (HP:0002370)	1.90963041
79	Agitation (HP:0000713)	1.90260357
80	Focal seizures (HP:0007359)	1.89927618
81	Abnormality of vitamin metabolism (HP:0100508)	1.88477279
82	Decreased testicular size (HP:0008734)	1.87291423
83	Proximal tubulopathy (HP:0000114)	1.85790874
84	Nephrotic syndrome (HP:0000100)	1.84817422
85	Abnormal ciliary motility (HP:0012262)	1.84478561
86	Abnormality of renin-angiotensin system (HP:0000847)	1.83860820
87	Congenital stationary night blindness (HP:0007642)	1.83802633
88	Lissencephaly (HP:0001339)	1.82796657
89	Metaphyseal dysplasia (HP:0100255)	1.81605576
90	Hypoglycemic seizures (HP:0002173)	1.81535872
91	Hamartoma of the eye (HP:0010568)	1.81122402
92	Increased CSF lactate (HP:0002490)	1.80906016
93	Oculomotor apraxia (HP:0000657)	1.80307510
94	Abnormality of the pancreatic islet cells (HP:0006476)	1.79831117
95	Abnormality of endocrine pancreas physiology (HP:0012093)	1.79831117
96	Gastrointestinal atresia (HP:0002589)	1.74151187
97	Increased circulating renin level (HP:0000848)	1.72444950
98	Hypolipoproteinemia (HP:0010981)	1.72397625
99	EEG with generalized epileptiform discharges (HP:0011198)	1.70849340
100	Hypoalphalipoproteinemia (HP:0003233)	1.70571563

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	7.26503450
2	FGFR2	2.93012318
3	TRIM28	2.72648994
4	WNK3	2.70785581
5	CSNK1G1	2.46066390
6	CSNK1G3	2.40237044
7	CLK1	2.39765055
8	ACVR1B	2.37310393
9	PIK3CG	2.33658269
10	MST4	2.30134199
11	CSNK1G2	2.26530468
12	PHKG2	2.04154181
13	PHKG1	2.04154181
14	MAP3K12	2.01946225
15	CASK	2.00036455
16	NTRK3	1.79428584
17	FER	1.78779405
18	EPHA3	1.66972396
19	NUAK1	1.65183558
20	PDK2	1.64878069
21	GRK1	1.63148365
22	ADRBK2	1.57374011
23	INSRR	1.56735826
24	EIF2AK3	1.53135616
25	OXSR1	1.52858955
26	NLK	1.50050996
27	CDK12	1.48534028
28	AKT3	1.46617479
29	PAK3	1.45176835
30	ERN1	1.36086114
31	PLK2	1.35271376
32	FGFR3	1.33720053
33	STK39	1.25732645
34	STK3	1.25379517
35	MAP3K2	1.16644258
36	PRKCE	1.14229485
37	SGK2	1.13651905
38	STK38L	1.12446194
39	PRKCI	1.10639828
40	IRAK1	1.02441979
41	BMPR1B	0.99389607
42	MAP4K2	0.94230247
43	TLK1	0.93416770
44	TAOK3	0.88682574
45	CSNK1A1	0.87837021
46	TNIK	0.82372556
47	MKNK2	0.78438413
48	NME1	0.77869846
49	PINK1	0.76295635
50	MAPK13	0.75906946
51	MAP2K6	0.74799941
52	PRKCG	0.74776120
53	TRPM7	0.74128623
54	WNK4	0.69885919
55	EIF2AK1	0.68993781
56	MAP3K4	0.68968424
57	BMPR2	0.65774839
58	JAK1	0.64475928
59	FGFR1	0.63427867
60	PIK3CA	0.62024482
61	CSNK1A1L	0.61673959
62	STK24	0.61193863
63	MYLK	0.59404303
64	FLT3	0.57983578
65	SGK494	0.57655532
66	SGK223	0.57655532
67	DYRK2	0.56268692
68	CSNK1E	0.55965856
69	PLK3	0.54861168
70	SGK3	0.53418063
71	STK16	0.51964610
72	MAP2K7	0.51844284
73	ERBB3	0.51495722
74	CSNK1D	0.47377422
75	STK38	0.46236176
76	ADRBK1	0.45087265
77	PRKAA1	0.45062960
78	PTK2B	0.44163803
79	CDK9	0.43204707
80	EPHA4	0.42971903
81	BRD4	0.41711007
82	ZAK	0.41258516
83	STK11	0.40690795
84	ROCK1	0.36950523
85	STK4	0.36911197
86	TIE1	0.36506308
87	IKBKB	0.36243771
88	CDK3	0.35717726
89	MAP2K1	0.34856882
90	MAP3K1	0.31427627
91	DAPK2	0.30604606
92	EPHB1	0.29049080
93	FGFR4	0.28416359
94	PRKG1	0.27694874
95	CAMK2D	0.26433272
96	HIPK2	0.25440916
97	GSK3A	0.25253091
98	PRKCA	0.23891340
99	RPS6KB1	0.23598866
100	PNCK	0.23348733

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	4.15842353
2	Maturity onset diabetes of the young_Homo sapiens_hsa04950	3.88383839
3	Nitrogen metabolism_Homo sapiens_hsa00910	2.61767185
4	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	2.55815754
5	Sulfur metabolism_Homo sapiens_hsa00920	2.39233629
6	Vitamin B6 metabolism_Homo sapiens_hsa00750	2.39107441
7	Protein export_Homo sapiens_hsa03060	2.35040734
8	Circadian rhythm_Homo sapiens_hsa04710	2.15460512
9	Butanoate metabolism_Homo sapiens_hsa00650	2.10692616
10	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.04980980
11	Primary bile acid biosynthesis_Homo sapiens_hsa00120	2.00957566
12	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.99216187
13	Phototransduction_Homo sapiens_hsa04744	1.98132317
14	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	1.78810675
15	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.74066338
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.67164388
17	Amphetamine addiction_Homo sapiens_hsa05031	1.53554836
18	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.51572670
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.46805370
20	Cocaine addiction_Homo sapiens_hsa05030	1.46614781
21	Ether lipid metabolism_Homo sapiens_hsa00565	1.38898267
22	Fatty acid elongation_Homo sapiens_hsa00062	1.38406620
23	Propanoate metabolism_Homo sapiens_hsa00640	1.36516914
24	Oxidative phosphorylation_Homo sapiens_hsa00190	1.36159993
25	Linoleic acid metabolism_Homo sapiens_hsa00591	1.29546664
26	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.28432248
27	Nicotine addiction_Homo sapiens_hsa05033	1.26941080
28	Collecting duct acid secretion_Homo sapiens_hsa04966	1.25659056
29	Basal transcription factors_Homo sapiens_hsa03022	1.25148801
30	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.25085621
31	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.24837609
32	Insulin secretion_Homo sapiens_hsa04911	1.23186167
33	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.21608456
34	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.20142669
35	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.18421158
36	Sphingolipid metabolism_Homo sapiens_hsa00600	1.18411098
37	Selenocompound metabolism_Homo sapiens_hsa00450	1.12936391
38	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.12185682
39	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.08603913
40	Peroxisome_Homo sapiens_hsa04146	1.05393865
41	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.05123861
42	Caffeine metabolism_Homo sapiens_hsa00232	1.02981619
43	Retinol metabolism_Homo sapiens_hsa00830	1.01894099
44	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.00555840
45	Chemical carcinogenesis_Homo sapiens_hsa05204	0.99443089
46	Fat digestion and absorption_Homo sapiens_hsa04975	0.97321548
47	ABC transporters_Homo sapiens_hsa02010	0.96128200
48	Fatty acid metabolism_Homo sapiens_hsa01212	0.96093826
49	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.93618588
50	Serotonergic synapse_Homo sapiens_hsa04726	0.91474502
51	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.90663727
52	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.89857096
53	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.89092730
54	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.88940002
55	Parkinsons disease_Homo sapiens_hsa05012	0.88663488
56	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.84907621
57	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.84860032
58	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.84186100
59	Dopaminergic synapse_Homo sapiens_hsa04728	0.83938735
60	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.80637474
61	Metabolic pathways_Homo sapiens_hsa01100	0.79685921
62	Steroid biosynthesis_Homo sapiens_hsa00100	0.79242154
63	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.77843577
64	Non-homologous end-joining_Homo sapiens_hsa03450	0.76523233
65	Taste transduction_Homo sapiens_hsa04742	0.75085197
66	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.74734314
67	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.74201869
68	Mineral absorption_Homo sapiens_hsa04978	0.73901074
69	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.72838426
70	Proteasome_Homo sapiens_hsa03050	0.70151397
71	Glutathione metabolism_Homo sapiens_hsa00480	0.69781262
72	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.68826809
73	Folate biosynthesis_Homo sapiens_hsa00790	0.66261195
74	Huntingtons disease_Homo sapiens_hsa05016	0.64596470
75	Other glycan degradation_Homo sapiens_hsa00511	0.64335385
76	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.63549259
77	One carbon pool by folate_Homo sapiens_hsa00670	0.62784009
78	Lysosome_Homo sapiens_hsa04142	0.62782360
79	Arginine and proline metabolism_Homo sapiens_hsa00330	0.62085017
80	beta-Alanine metabolism_Homo sapiens_hsa00410	0.61916603
81	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.59554629
82	Type II diabetes mellitus_Homo sapiens_hsa04930	0.59419320
83	RNA degradation_Homo sapiens_hsa03018	0.59216797
84	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.53288409
85	Circadian entrainment_Homo sapiens_hsa04713	0.53286560
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.52910778
87	Glutamatergic synapse_Homo sapiens_hsa04724	0.52368825
88	Complement and coagulation cascades_Homo sapiens_hsa04610	0.52359334
89	Fatty acid degradation_Homo sapiens_hsa00071	0.49882503
90	Calcium signaling pathway_Homo sapiens_hsa04020	0.48384172
91	Cardiac muscle contraction_Homo sapiens_hsa04260	0.48106832
92	Alzheimers disease_Homo sapiens_hsa05010	0.47419371
93	GABAergic synapse_Homo sapiens_hsa04727	0.46228832
94	Histidine metabolism_Homo sapiens_hsa00340	0.46035879
95	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.44946966
96	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.44735219
97	RNA polymerase_Homo sapiens_hsa03020	0.43659614
98	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.41914359
99	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.41470466
100	Arginine biosynthesis_Homo sapiens_hsa00220	0.39222098

NFE2L3P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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