NFIA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the NF1 (nuclear factor 1) family of transcription factors. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of pigment cell differentiation (GO:0050932)5.24204867
2glial cell proliferation (GO:0014009)5.18989838
3presynaptic membrane assembly (GO:0097105)4.80456019
4neural tube formation (GO:0001841)4.74751790
5negative regulation of dendrite development (GO:2000171)4.52837090
6limb bud formation (GO:0060174)4.50277773
7glomerulus development (GO:0032835)4.48816352
8postsynaptic membrane organization (GO:0001941)4.45949888
9facial nerve structural organization (GO:0021612)4.41124361
10pyrimidine nucleobase catabolic process (GO:0006208)4.37914487
11neurotransmitter-gated ion channel clustering (GO:0072578)4.36175940
12presynaptic membrane organization (GO:0097090)4.21184125
13cerebral cortex radially oriented cell migration (GO:0021799)4.17916585
14cranial nerve structural organization (GO:0021604)4.00879851
15negative regulation of astrocyte differentiation (GO:0048712)3.97367637
16cell differentiation involved in metanephros development (GO:0072202)3.85530419
17cardiac ventricle formation (GO:0003211)3.82130182
18hindbrain development (GO:0030902)3.76706358
19regulation of collateral sprouting (GO:0048670)3.75697137
20mesenchymal cell differentiation involved in renal system development (GO:2001012)3.69671539
21mesenchymal cell differentiation involved in kidney development (GO:0072161)3.69671539
22sympathetic nervous system development (GO:0048485)3.66377486
23negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.61302848
24positive regulation of male gonad development (GO:2000020)3.60485292
25olfactory bulb development (GO:0021772)3.58833425
26nucleobase catabolic process (GO:0046113)3.51661290
27cornea development in camera-type eye (GO:0061303)3.51071504
28cardiac chamber formation (GO:0003207)3.49479368
29transmission of nerve impulse (GO:0019226)3.42849562
30regulation of non-canonical Wnt signaling pathway (GO:2000050)3.40684275
31short-term memory (GO:0007614)3.39960007
32metanephric nephron tubule development (GO:0072234)3.39762248
33metanephric tubule development (GO:0072170)3.39762248
34negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.39475484
35negative regulation of translation, ncRNA-mediated (GO:0040033)3.39475484
36regulation of translation, ncRNA-mediated (GO:0045974)3.39475484
37endocardial cushion morphogenesis (GO:0003203)3.32272810
38central nervous system projection neuron axonogenesis (GO:0021952)3.31824668
39negative regulation of keratinocyte proliferation (GO:0010839)3.29174027
40forebrain neuron differentiation (GO:0021879)3.28555149
41DNA double-strand break processing (GO:0000729)3.28205571
42mesenchymal cell development (GO:0014031)3.27206198
43regulation of timing of cell differentiation (GO:0048505)3.25123811
44keratinocyte development (GO:0003334)3.24650868
45ionotropic glutamate receptor signaling pathway (GO:0035235)3.22098726
46inner ear receptor stereocilium organization (GO:0060122)3.17751058
47photoreceptor cell differentiation (GO:0046530)3.15009248
48eye photoreceptor cell differentiation (GO:0001754)3.15009248
49mesenchyme morphogenesis (GO:0072132)3.13738696
50anatomical structure arrangement (GO:0048532)3.13093711
51cranial nerve morphogenesis (GO:0021602)3.11928257
52negative regulation of axon extension (GO:0030517)3.11142765
53negative regulation of DNA binding (GO:0043392)3.10849864
54sequestering of extracellular ligand from receptor (GO:0035581)3.08833429
55central nervous system neuron axonogenesis (GO:0021955)3.07197273
56peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.02704101
57negative regulation of osteoblast proliferation (GO:0033689)3.00829811
58central nervous system myelination (GO:0022010)3.00153043
59axon ensheathment in central nervous system (GO:0032291)3.00153043
60ventricular septum morphogenesis (GO:0060412)2.99718724
61lung secretory cell differentiation (GO:0061140)2.98252720
62omega-hydroxylase P450 pathway (GO:0097267)2.97867611
63neuron cell-cell adhesion (GO:0007158)2.97820999
64metanephric nephron epithelium development (GO:0072243)2.95277918
65glutamate receptor signaling pathway (GO:0007215)2.94368370
66regulation of development, heterochronic (GO:0040034)2.91632336
67atrial cardiac muscle cell action potential (GO:0086014)2.88884167
68metanephric epithelium development (GO:0072207)2.87456148
69oligodendrocyte differentiation (GO:0048709)2.85109576
70somite development (GO:0061053)2.83580108
71negative regulation of protein localization to cell surface (GO:2000009)2.82648142
72regulation of hippo signaling (GO:0035330)2.82633328
73regulation of keratinocyte proliferation (GO:0010837)2.81115941
74nephron epithelium development (GO:0072009)2.79493343
75cerebral cortex cell migration (GO:0021795)2.79471176
76dermatan sulfate biosynthetic process (GO:0030208)2.77841047
77nephron tubule development (GO:0072080)2.77784051
78mesonephros development (GO:0001823)2.77394583
79extracellular regulation of signal transduction (GO:1900115)2.77328708
80extracellular negative regulation of signal transduction (GO:1900116)2.77328708
81stem cell development (GO:0048864)2.74876588
82neural crest cell development (GO:0014032)2.73917532
83regulation of mesenchymal cell apoptotic process (GO:2001053)2.72934666
84negative regulation of stem cell proliferation (GO:2000647)2.71977918
85pattern specification involved in kidney development (GO:0061004)2.71443002
86righting reflex (GO:0060013)2.71313706
87kidney morphogenesis (GO:0060993)2.70142818
88cell differentiation involved in kidney development (GO:0061005)2.68743925
89positive regulation of protein kinase C signaling (GO:0090037)2.68484120
90dermatan sulfate metabolic process (GO:0030205)2.68202373
91substrate-independent telencephalic tangential migration (GO:0021826)2.67919841
92substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.67919841
93spinal cord development (GO:0021510)2.67141524
94negative regulation of protein oligomerization (GO:0032460)2.66702445
95detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.66620953
96cellular response to sterol (GO:0036315)2.66193358
97retinal rod cell development (GO:0046548)2.65937968
98positive regulation of synapse assembly (GO:0051965)2.65604266
99lateral sprouting from an epithelium (GO:0060601)2.64999269
100embryonic epithelial tube formation (GO:0001838)2.63913911
101vocalization behavior (GO:0071625)2.61689522
102regulation of axon extension involved in axon guidance (GO:0048841)2.61174141
103relaxation of smooth muscle (GO:0044557)2.60930214
104protein localization to synapse (GO:0035418)2.59585194
105cochlea development (GO:0090102)2.59192897
106startle response (GO:0001964)2.56505194
107dendrite morphogenesis (GO:0048813)2.56346772
108response to auditory stimulus (GO:0010996)2.56311984
109regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.56283258
110regulation of male gonad development (GO:2000018)2.55272407
111enteric nervous system development (GO:0048484)2.55022185
112androgen biosynthetic process (GO:0006702)2.54968347
113G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.54387859
114renal tubule development (GO:0061326)2.53487717
115behavioral response to ethanol (GO:0048149)2.53254177
116dentate gyrus development (GO:0021542)2.53245391
117C4-dicarboxylate transport (GO:0015740)2.52975473
118retina layer formation (GO:0010842)2.52649787
119microtubule depolymerization (GO:0007019)2.52601882
120axonal fasciculation (GO:0007413)2.52593247
121neuron fate determination (GO:0048664)2.52547594
122cellular response to cholesterol (GO:0071397)2.52282321
123cilium morphogenesis (GO:0060271)2.52194194
124melanin metabolic process (GO:0006582)2.51779207
125embryonic digestive tract morphogenesis (GO:0048557)2.51250419
126positive regulation of amino acid transport (GO:0051957)2.50838264
127negative regulation of axon guidance (GO:1902668)2.49758178
128epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.49462084
129retinal ganglion cell axon guidance (GO:0031290)2.48306579
130negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.47883277
131dendritic spine morphogenesis (GO:0060997)2.47210523
132negative chemotaxis (GO:0050919)2.47064103
133otic vesicle formation (GO:0030916)2.46503645
134metanephric mesenchyme development (GO:0072075)2.46390083
135cell proliferation in forebrain (GO:0021846)2.46355853
136negative regulation of axon extension involved in axon guidance (GO:0048843)2.46011290
137tachykinin receptor signaling pathway (GO:0007217)2.45729180
138epithelial tube formation (GO:0072175)2.45522921
139fibroblast migration (GO:0010761)2.44850019
140limb development (GO:0060173)2.44760252
141appendage development (GO:0048736)2.44760252
142forebrain neuron development (GO:0021884)2.44547404
143chondroitin sulfate catabolic process (GO:0030207)2.44403229
144membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.44100370
145microtubule anchoring (GO:0034453)2.42939002
146positive regulation of sodium ion transmembrane transport (GO:1902307)2.42938282
147regulation of neurotransmitter uptake (GO:0051580)2.42222331
148regulation of somitogenesis (GO:0014807)2.42082310
149negative regulation of cytosolic calcium ion concentration (GO:0051481)2.41438375
150epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.41185994
151glial cell differentiation (GO:0010001)2.41030843
152heart valve formation (GO:0003188)2.40887071
153epithelial cilium movement (GO:0003351)2.40531129
154mechanosensory behavior (GO:0007638)2.40431182
155positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.40399503
156negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.39759304
157regulation of axon guidance (GO:1902667)2.39305622
158positive regulation of vascular permeability (GO:0043117)2.39293488
159detection of light stimulus involved in sensory perception (GO:0050962)2.39262050
160detection of light stimulus involved in visual perception (GO:0050908)2.39262050
161synapse assembly (GO:0007416)2.39232691
162neuronal action potential propagation (GO:0019227)2.38809350
163protein heterotetramerization (GO:0051290)2.38780061
164regulation of dendritic spine development (GO:0060998)2.38305310
165neuron recognition (GO:0008038)2.38118966
166negative regulation of transcription regulatory region DNA binding (GO:2000678)2.38022021
167regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.37981430

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.97512344
2GBX2_23144817_ChIP-Seq_PC3_Human3.63815368
3AR_21572438_ChIP-Seq_LNCaP_Human3.04779250
4EED_16625203_ChIP-ChIP_MESCs_Mouse2.83363166
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.82670578
6SALL1_21062744_ChIP-ChIP_HESCs_Human2.82293101
7* EZH2_27304074_Chip-Seq_ESCs_Mouse2.75673750
8* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.71374530
9* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.68717184
10* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.66406492
11* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60911056
12* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60911056
13ZNF274_21170338_ChIP-Seq_K562_Hela2.54468761
14* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.54100221
15* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.46355773
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36868494
17* CBX2_27304074_Chip-Seq_ESCs_Mouse2.34330408
18* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.33265512
19* RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.29089127
20HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.20404718
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18401118
22BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.13836793
23* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11927443
24GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.11590376
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11052665
26* EZH2_27294783_Chip-Seq_ESCs_Mouse2.06805696
27* RNF2_27304074_Chip-Seq_ESCs_Mouse2.06354665
28PIAS1_25552417_ChIP-Seq_VCAP_Human2.04601840
29BMI1_23680149_ChIP-Seq_NPCS_Mouse2.03852164
30* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.00821110
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.94407927
32* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.91768950
33IGF1R_20145208_ChIP-Seq_DFB_Human1.90303318
34* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87164089
35TAF15_26573619_Chip-Seq_HEK293_Human1.84629102
36* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82079627
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80289405
38POU3F2_20337985_ChIP-ChIP_501MEL_Human1.75205674
39* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.74253429
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.71272996
41FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69792446
42* P300_19829295_ChIP-Seq_ESCs_Human1.68305396
43RNF2_27304074_Chip-Seq_NSC_Mouse1.66431377
44NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.66148867
45TRIM28_21343339_ChIP-Seq_HEK293_Human1.59917277
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.56799500
47* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52251020
48FUS_26573619_Chip-Seq_HEK293_Human1.51426601
49TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50955776
50* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.50653286
51SMAD3_21741376_ChIP-Seq_EPCs_Human1.50144418
52* SMAD4_21799915_ChIP-Seq_A2780_Human1.47971148
53SMAD_19615063_ChIP-ChIP_OVARY_Human1.44859598
54REST_21632747_ChIP-Seq_MESCs_Mouse1.44660237
55CBP_20019798_ChIP-Seq_JUKART_Human1.39956387
56IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39956387
57* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39926229
58EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.32602397
59PCGF2_27294783_Chip-Seq_ESCs_Mouse1.32181944
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.31855285
61* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.31700916
62CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.31154409
63ER_23166858_ChIP-Seq_MCF-7_Human1.31077631
64ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.30781930
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29967949
66TP53_18474530_ChIP-ChIP_U2OS_Human1.29940090
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29535653
68* TP53_20018659_ChIP-ChIP_R1E_Mouse1.29439524
69TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28634823
70* RING1B_27294783_Chip-Seq_NPCs_Mouse1.28581439
71* SOX9_26525672_Chip-Seq_HEART_Mouse1.27104167
72* NANOG_18555785_Chip-Seq_ESCs_Mouse1.25015250
73SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.24453902
74NR3C1_21868756_ChIP-Seq_MCF10A_Human1.24237113
75SOX2_21211035_ChIP-Seq_LN229_Gbm1.23699211
76FLI1_27457419_Chip-Seq_LIVER_Mouse1.21631268
77TCF4_22108803_ChIP-Seq_LS180_Human1.21581634
78PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19584773
79TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18065894
80E2F1_18555785_Chip-Seq_ESCs_Mouse1.17658030
81* AR_25329375_ChIP-Seq_VCAP_Human1.16769237
82* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.16735759
83* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.16540027
84FLI1_21867929_ChIP-Seq_TH2_Mouse1.16418995
85P53_22387025_ChIP-Seq_ESCs_Mouse1.15647315
86* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15498912
87NFE2_27457419_Chip-Seq_LIVER_Mouse1.15104341
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15002412
89* RING1B_27294783_Chip-Seq_ESCs_Mouse1.14956653
90WT1_19549856_ChIP-ChIP_CCG9911_Human1.14482835
91* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.14321425
92* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13577297
93KLF5_20875108_ChIP-Seq_MESCs_Mouse1.13386071
94TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.13114597
95SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12772279
96VDR_22108803_ChIP-Seq_LS180_Human1.12686597
97AHR_22903824_ChIP-Seq_MCF-7_Human1.12066635
98* RUNX2_22187159_ChIP-Seq_PCA_Human1.09948285
99CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09891375
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09676450
101* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09480035
102* BCAT_22108803_ChIP-Seq_LS180_Human1.09368046
103RBPJ_22232070_ChIP-Seq_NCS_Mouse1.08895752
104ARNT_22903824_ChIP-Seq_MCF-7_Human1.07498517
105EZH2_27294783_Chip-Seq_NPCs_Mouse1.07308312
106CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07291873
107DROSHA_22980978_ChIP-Seq_HELA_Human1.06857723
108EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.06740628
109CMYC_18555785_Chip-Seq_ESCs_Mouse1.04970501
110VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.04107161
111P300_18555785_Chip-Seq_ESCs_Mouse1.03326475
112CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03212190
113GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03182502
114TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02713175
115POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02713175
116* STAT3_23295773_ChIP-Seq_U87_Human1.02478762
117* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01590542
118EP300_21415370_ChIP-Seq_HL-1_Mouse1.00462951
119ESR1_20079471_ChIP-ChIP_T-47D_Human1.00334566
120TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00238730
121TCF4_23295773_ChIP-Seq_U87_Human0.99408956
122KDM2B_26808549_Chip-Seq_REH_Human0.98261258
123CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98260820
124EWS_26573619_Chip-Seq_HEK293_Human0.96702154

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color4.32006988
2MP0001188_hyperpigmentation3.51278730
3MP0009379_abnormal_foot_pigmentation3.31355239
4MP0005409_darkened_coat_color3.22298130
5MP0000566_synostosis2.67725737
6MP0005503_abnormal_tendon_morphology2.65090059
7MP0006292_abnormal_olfactory_placode2.57738784
8MP0004381_abnormal_hair_follicle2.53305715
9MP0000049_abnormal_middle_ear2.48355469
10MP0003880_abnormal_central_pattern2.43171587
11MP0002234_abnormal_pharynx_morphology2.30985573
12MP0005171_absent_coat_pigmentation2.29582507
13MP0005367_renal/urinary_system_phenotyp2.27964320
14MP0000516_abnormal_urinary_system2.27964320
15MP0009384_cardiac_valve_regurgitation1.99701924
16MP0000569_abnormal_digit_pigmentation1.99520386
17MP0002249_abnormal_larynx_morphology1.99137837
18MP0009250_abnormal_appendicular_skeleto1.93009589
19MP0004859_abnormal_synaptic_plasticity1.92396105
20MP0001529_abnormal_vocalization1.90631828
21MP0003385_abnormal_body_wall1.87313740
22MP0005187_abnormal_penis_morphology1.82221994
23MP0001486_abnormal_startle_reflex1.77708840
24MP0008438_abnormal_cutaneous_collagen1.77322705
25* MP0000778_abnormal_nervous_system1.71691368
26MP0000015_abnormal_ear_pigmentation1.69690442
27MP0003011_delayed_dark_adaptation1.64949380
28MP0008789_abnormal_olfactory_epithelium1.64504998
29MP0000372_irregular_coat_pigmentation1.57083527
30MP0003787_abnormal_imprinting1.52325361
31MP0001984_abnormal_olfaction1.51597616
32MP0002751_abnormal_autonomic_nervous1.51593496
33MP0002063_abnormal_learning/memory/cond1.49395648
34MP0005551_abnormal_eye_electrophysiolog1.48752608
35MP0010368_abnormal_lymphatic_system1.48171520
36MP0000631_abnormal_neuroendocrine_gland1.46385389
37MP0001346_abnormal_lacrimal_gland1.45943707
38MP0002177_abnormal_outer_ear1.45856396
39MP0002009_preneoplasia1.45767446
40MP0000026_abnormal_inner_ear1.37548298
41MP0004145_abnormal_muscle_electrophysio1.37134894
42MP0006276_abnormal_autonomic_nervous1.36609650
43MP0004885_abnormal_endolymph1.36596010
44MP0004924_abnormal_behavior1.35556408
45MP0005386_behavior/neurological_phenoty1.35556408
46MP0008877_abnormal_DNA_methylation1.34845833
47MP0000647_abnormal_sebaceous_gland1.34219275
48MP0008872_abnormal_physiological_respon1.30534037
49MP0002067_abnormal_sensory_capabilities1.30337998
50MP0000751_myopathy1.28894854
51MP0003755_abnormal_palate_morphology1.28802988
52MP0002876_abnormal_thyroid_physiology1.28012094
53MP0002184_abnormal_innervation1.27815821
54MP0002938_white_spotting1.26616254
55MP0001968_abnormal_touch/_nociception1.24357903
56MP0004272_abnormal_basement_membrane1.21868364
57MP0001879_abnormal_lymphatic_vessel1.21833416
58MP0005595_abnormal_vascular_smooth1.20940153
59MP0001501_abnormal_sleep_pattern1.20276525
60MP0000428_abnormal_craniofacial_morphol1.19968837
61MP0002272_abnormal_nervous_system1.18983159
62MP0002752_abnormal_somatic_nervous1.18974442
63MP0002233_abnormal_nose_morphology1.18880414
64MP0003938_abnormal_ear_development1.18783723
65MP0010030_abnormal_orbit_morphology1.18741930
66MP0002734_abnormal_mechanical_nocicepti1.16592439
67MP0004142_abnormal_muscle_tone1.15451103
68MP0001177_atelectasis1.15026409
69MP0000762_abnormal_tongue_morphology1.14154508
70MP0002735_abnormal_chemical_nociception1.13378505
71MP0009046_muscle_twitch1.13260701
72MP0001970_abnormal_pain_threshold1.13109559
73MP0005499_abnormal_olfactory_system1.12124774
74MP0005394_taste/olfaction_phenotype1.12124774
75MP0002653_abnormal_ependyma_morphology1.11382358
76MP0001502_abnormal_circadian_rhythm1.10794398
77* MP0003861_abnormal_nervous_system1.10747020
78MP0002736_abnormal_nociception_after1.10268190
79MP0004043_abnormal_pH_regulation1.09765749
80MP0005275_abnormal_skin_tensile1.06694937
81MP0003121_genomic_imprinting1.05805590
82MP0001963_abnormal_hearing_physiology1.05798229
83MP0000538_abnormal_urinary_bladder1.04809086
84MP0001270_distended_abdomen1.03826344
85MP0002557_abnormal_social/conspecific_i1.03689345
86* MP0002152_abnormal_brain_morphology1.03089715
87MP0005646_abnormal_pituitary_gland1.02610021
88MP0002116_abnormal_craniofacial_bone1.02055652
89MP0003937_abnormal_limbs/digits/tail_de1.01170597
90MP0002108_abnormal_muscle_morphology1.00625935
91MP0009053_abnormal_anal_canal1.00190626
92MP0003137_abnormal_impulse_conducting0.99786994
93* MP0000955_abnormal_spinal_cord0.98367815
94MP0005195_abnormal_posterior_eye0.97725126
95MP0001986_abnormal_taste_sensitivity0.97009351
96MP0001485_abnormal_pinna_reflex0.95280706
97MP0003935_abnormal_craniofacial_develop0.95185760
98MP0003635_abnormal_synaptic_transmissio0.94943464
99MP0004811_abnormal_neuron_physiology0.93399682
100MP0005391_vision/eye_phenotype0.92840673
101MP0004270_analgesia0.92111928
102MP0005257_abnormal_intraocular_pressure0.91543585
103MP0002282_abnormal_trachea_morphology0.90846287
104MP0005248_abnormal_Harderian_gland0.90547097
105MP0004134_abnormal_chest_morphology0.90058156
106MP0004742_abnormal_vestibular_system0.89971922
107MP0000537_abnormal_urethra_morphology0.89156955
108MP0008569_lethality_at_weaning0.88068333
109MP0002733_abnormal_thermal_nociception0.87858362
110MP0002102_abnormal_ear_morphology0.87053996
111MP0005253_abnormal_eye_physiology0.86435577
112* MP0000534_abnormal_ureter_morphology0.86335639
113MP0009745_abnormal_behavioral_response0.85860871
114MP0001299_abnormal_eye_distance/0.85066962
115MP0001286_abnormal_eye_development0.84859532
116MP0002932_abnormal_joint_morphology0.84651247
117* MP0002882_abnormal_neuron_morphology0.84330149
118MP0001340_abnormal_eyelid_morphology0.83526389
119MP0000579_abnormal_nail_morphology0.83206421
120MP0005174_abnormal_tail_pigmentation0.83156412
121MP0005423_abnormal_somatic_nervous0.83153886
122MP0000613_abnormal_salivary_gland0.83013832
123MP0000749_muscle_degeneration0.82424537
124MP0002638_abnormal_pupillary_reflex0.81726945
125* MP0003942_abnormal_urinary_system0.81706180
126MP0003119_abnormal_digestive_system0.81162310
127MP0000163_abnormal_cartilage_morphology0.80887864
128MP0004215_abnormal_myocardial_fiber0.79639310
129MP0002064_seizures0.79241308
130MP0002572_abnormal_emotion/affect_behav0.79009443
131MP0006072_abnormal_retinal_apoptosis0.78166721
132MP0003633_abnormal_nervous_system0.77832341
133MP0002081_perinatal_lethality0.75027611
134* MP0002066_abnormal_motor_capabilities/c0.74756035
135MP0002111_abnormal_tail_morphology0.71620613
136MP0004085_abnormal_heartbeat0.70049506
137MP0002837_dystrophic_cardiac_calcinosis0.69821375
138MP0003122_maternal_imprinting0.68983101

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the axillary hair (HP:0100134)3.95720480
2Abnormality of secondary sexual hair (HP:0009888)3.95720480
3Abnormality of the labia minora (HP:0012880)3.93459579
4Septo-optic dysplasia (HP:0100842)3.82792211
5Focal seizures (HP:0007359)3.69276567
6Sex reversal (HP:0012245)3.43667229
7Abnormal sex determination (HP:0012244)3.43667229
8Optic nerve hypoplasia (HP:0000609)3.35306007
9Short 4th metacarpal (HP:0010044)3.33168901
10Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.33168901
11Obstructive sleep apnea (HP:0002870)3.29904202
12Pancreatic cysts (HP:0001737)3.20975730
13Drooling (HP:0002307)3.17328319
14Febrile seizures (HP:0002373)2.97233965
15Congenital stationary night blindness (HP:0007642)2.94611605
16Hemiparesis (HP:0001269)2.89816640
17Excessive salivation (HP:0003781)2.87944187
18Renal hypoplasia (HP:0000089)2.85097490
19Hypothermia (HP:0002045)2.83504600
20Abnormality of midbrain morphology (HP:0002418)2.79028640
21Molar tooth sign on MRI (HP:0002419)2.79028640
22Absent septum pellucidum (HP:0001331)2.74614235
23Increased corneal curvature (HP:0100692)2.73929670
24Keratoconus (HP:0000563)2.73929670
25Pulmonary artery stenosis (HP:0004415)2.72234898
26Aplasia/Hypoplasia of the sternum (HP:0006714)2.70760330
27True hermaphroditism (HP:0010459)2.70031136
28Hepatoblastoma (HP:0002884)2.68616652
29Hypoplastic left heart (HP:0004383)2.63344943
30Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.58770473
31Abnormality of the septum pellucidum (HP:0007375)2.58572183
32Tented upper lip vermilion (HP:0010804)2.58076397
33Volvulus (HP:0002580)2.56612987
34Chronic hepatic failure (HP:0100626)2.55388857
35Intestinal atresia (HP:0011100)2.52554694
36Abnormality of the 4th metacarpal (HP:0010012)2.51552907
37Short tibia (HP:0005736)2.46814313
38Split foot (HP:0001839)2.45976297
39Cystic liver disease (HP:0006706)2.45893872
40Long clavicles (HP:0000890)2.45638479
41Aplasia/Hypoplasia of the tibia (HP:0005772)2.43820129
42Abnormality of the phalanges of the hallux (HP:0010057)2.43312823
43Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.41220550
44Narrow forehead (HP:0000341)2.39991990
45Aplasia involving bones of the extremities (HP:0009825)2.38549575
46Aplasia involving bones of the upper limbs (HP:0009823)2.38549575
47Aplasia of the phalanges of the hand (HP:0009802)2.38549575
48Nonprogressive disorder (HP:0003680)2.36855311
49Astrocytoma (HP:0009592)2.36347203
50Abnormality of the astrocytes (HP:0100707)2.36347203
51Tubulointerstitial nephritis (HP:0001970)2.36314268
52Abnormal ciliary motility (HP:0012262)2.36123885
53Nephronophthisis (HP:0000090)2.34421760
54Agitation (HP:0000713)2.34298676
55Sleep apnea (HP:0010535)2.32480040
56Fair hair (HP:0002286)2.32229627
57Nasolacrimal duct obstruction (HP:0000579)2.31122487
58Severe visual impairment (HP:0001141)2.31085846
59Broad-based gait (HP:0002136)2.30999799
60Absent speech (HP:0001344)2.27296277
61Synostosis involving the elbow (HP:0003938)2.26233995
62Humeroradial synostosis (HP:0003041)2.26233995
63Cutaneous finger syndactyly (HP:0010554)2.25077179
64Ulnar claw (HP:0001178)2.24431091
65Thyroid-stimulating hormone excess (HP:0002925)2.23831746
66Oligodactyly (hands) (HP:0001180)2.23464379
67Concave nail (HP:0001598)2.21582910
68Glioma (HP:0009733)2.20500122
69Decreased central vision (HP:0007663)2.19807366
70Hyperventilation (HP:0002883)2.19644516
71Exotropia (HP:0000577)2.18560064
72White forelock (HP:0002211)2.17789088
73Abnormality of incisor morphology (HP:0011063)2.17471590
74Focal motor seizures (HP:0011153)2.17170415
75Bradycardia (HP:0001662)2.16659881
76Hypoplastic heart (HP:0001961)2.16563725
77Abnormality of the renal medulla (HP:0100957)2.11751477
78Atonic seizures (HP:0010819)2.10090425
79Cupped ear (HP:0000378)2.09943217
80Lissencephaly (HP:0001339)2.09703566
81Alacrima (HP:0000522)2.09693031
82Generalized tonic-clonic seizures (HP:0002069)2.09504895
83Type I transferrin isoform profile (HP:0003642)2.09003540
84Widely spaced teeth (HP:0000687)2.08575194
85Patchy hypopigmentation of hair (HP:0011365)2.07613218
86Postaxial hand polydactyly (HP:0001162)2.06370542
87Cutaneous syndactyly (HP:0012725)2.06226038
88Sclerocornea (HP:0000647)2.05888079
89Laryngomalacia (HP:0001601)2.04943640
90Anencephaly (HP:0002323)2.04189123
91Renal Fanconi syndrome (HP:0001994)2.03548536
92Impaired social interactions (HP:0000735)2.02889259
93Abnormal social behavior (HP:0012433)2.02889259
94Coronal craniosynostosis (HP:0004440)2.02696721
95Protruding tongue (HP:0010808)2.00618600
96Progressive cerebellar ataxia (HP:0002073)1.99921790
97Bifid scrotum (HP:0000048)1.98835465
98Retinal dysplasia (HP:0007973)1.98788633
99Abnormality of the antihelix (HP:0009738)1.98727994
100Limited hip movement (HP:0008800)1.98471197
101Hypoplasia of the fovea (HP:0007750)1.97245155
102Aplasia/Hypoplasia of the fovea (HP:0008060)1.97245155
103Abnormality of the nasolacrimal system (HP:0000614)1.96951559
104Medial flaring of the eyebrow (HP:0010747)1.96493130
105Midline defect of the nose (HP:0004122)1.96469367
106Dialeptic seizures (HP:0011146)1.95682837
107Reduced antithrombin III activity (HP:0001976)1.95559191
108Abnormality of renal resorption (HP:0011038)1.94726900
109Pachygyria (HP:0001302)1.94434771
110Patellar aplasia (HP:0006443)1.94207240
111Fibular hypoplasia (HP:0003038)1.94204398
112Tracheomalacia (HP:0002779)1.93960234
113Occipital encephalocele (HP:0002085)1.93678449
114Genital tract atresia (HP:0001827)1.93541710
115Lymphangioma (HP:0100764)1.93239328
116Action tremor (HP:0002345)1.92910275
117Gastroesophageal reflux (HP:0002020)1.92906726
118Neoplasm of the oral cavity (HP:0100649)1.92821214
119Megalencephaly (HP:0001355)1.92359226
120Abnormal respiratory motile cilium physiology (HP:0012261)1.91765423
121Corneal dystrophy (HP:0001131)1.91603208
122Dynein arm defect of respiratory motile cilia (HP:0012255)1.91302340
123Absent/shortened dynein arms (HP:0200106)1.91302340
124Gait imbalance (HP:0002141)1.90974987
125Optic disc pallor (HP:0000543)1.90754693
126Abnormality of the lacrimal duct (HP:0011481)1.90579510
127Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.89229153
128Steppage gait (HP:0003376)1.88858077
129Congenital hepatic fibrosis (HP:0002612)1.88140668
130Postaxial foot polydactyly (HP:0001830)1.87800996
131Abnormality of the renal cortex (HP:0011035)1.86217141
132Congenital sensorineural hearing impairment (HP:0008527)1.86181358
133Stage 5 chronic kidney disease (HP:0003774)1.85797464
134Facial hemangioma (HP:0000329)1.85111329
135Abnormal biliary tract physiology (HP:0012439)1.85063287
136Bile duct proliferation (HP:0001408)1.85063287
137Abnormality of the pubic bones (HP:0003172)1.84880330
138Narrow nasal bridge (HP:0000446)1.84584817
139Adrenal hypoplasia (HP:0000835)1.84446226
140Abnormality of the ischium (HP:0003174)1.84350910
141Renal dysplasia (HP:0000110)1.83857849
142Myelomeningocele (HP:0002475)1.83841070
143Poor eye contact (HP:0000817)1.83502184
144Intellectual disability, moderate (HP:0002342)1.83271027
145Gastrointestinal atresia (HP:0002589)1.83182428
146Atrial fibrillation (HP:0005110)1.82252700
147Overgrowth (HP:0001548)1.81944521
148Broad metatarsal (HP:0001783)1.81583347
149Abnormality of the heme biosynthetic pathway (HP:0010472)1.81025975
150Abnormality of the metopic suture (HP:0005556)1.80925014
151Dandy-Walker malformation (HP:0001305)1.80511722
152Aplasia/Hypoplasia of the lens (HP:0008063)1.79442527
153Vaginal atresia (HP:0000148)1.79045370
154Pancreatic fibrosis (HP:0100732)1.78671103
155Submucous cleft hard palate (HP:0000176)1.78237254
156Attenuation of retinal blood vessels (HP:0007843)1.76972349
157Aplasia/Hypoplasia of the patella (HP:0006498)1.76640765
158Epileptic encephalopathy (HP:0200134)1.75669270
159Ependymoma (HP:0002888)1.75075570
160Type II lissencephaly (HP:0007260)1.73770289
161Gaze-evoked nystagmus (HP:0000640)1.73708516
162Limb dystonia (HP:0002451)1.73616485
163Aplasia/Hypoplasia of the tongue (HP:0010295)1.73234654
164Morphological abnormality of the middle ear (HP:0008609)1.72973886
165Pendular nystagmus (HP:0012043)1.72368881
166Microglossia (HP:0000171)1.72345755
167Abnormal rod and cone electroretinograms (HP:0008323)1.70837846
168Wide anterior fontanel (HP:0000260)1.70530981
169Decreased lacrimation (HP:0000633)1.69554118
170Dyskinesia (HP:0100660)1.69069244
171Small hand (HP:0200055)1.68706141
172Hypoplastic ischia (HP:0003175)1.67346942
173Preaxial hand polydactyly (HP:0001177)1.67303366
174Intellectual disability, progressive (HP:0006887)1.66264151
175Oligodactyly (HP:0012165)1.65979311

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK7.27951379
2MKNK24.40361228
3TNIK3.85022154
4FRK3.71984730
5WNK33.65987140
6MUSK3.47979888
7PRPF4B3.02505906
8EPHA32.69742673
9PNCK2.55114798
10MKNK12.54541482
11TLK12.48183344
12YES12.12702943
13PHKG21.85536934
14PHKG11.85536934
15MAPK131.81108734
16MAP2K71.66413873
17CCNB11.64802418
18TRIM281.64328022
19EPHA41.48842019
20INSRR1.48228274
21MAP4K21.42457231
22WEE11.34729457
23IRAK11.31051506
24SGK21.30923368
25FGFR21.29773744
26STK161.27909799
27NLK1.25943291
28EPHB21.25865019
29MARK11.22155320
30LATS11.18867423
31ZAK1.17752880
32EIF2AK21.15321316
33PAK31.13933714
34PKN11.13222529
35SGK2231.11842952
36SGK4941.11842952
37NTRK31.06107902
38IRAK21.04918516
39BRSK21.04808099
40FER1.01365103
41DYRK1A0.99622674
42STK390.93196935
43CDK30.93112089
44UHMK10.92371662
45AKT30.92299655
46CSNK1G20.92278940
47LMTK20.91188128
48DYRK20.90869059
49SIK20.90777413
50CAMK1G0.90679578
51SRPK10.89359257
52PLK40.89312622
53NEK60.87589375
54FES0.85415039
55GRK70.84197882
56BMPR20.77440156
57CAMKK20.77304668
58PRKCZ0.76619785
59PRKCE0.76377046
60CAMK40.76302046
61PRKD30.76275142
62MAPK150.75447599
63CDK80.74924073
64ROCK10.74456860
65PLK30.73133081
66BMPR1B0.72594847
67ERBB30.72177313
68PLK20.72081756
69TIE10.71508374
70PRKD20.71268383
71CSNK1G30.70573057
72ADRBK20.67689664
73PIK3CA0.66782536
74CSNK1A1L0.66590105
75CAMK2A0.65995866
76TAOK10.65258577
77CAMK10.64302150
78BUB10.64068855
79CDK190.63868566
80OXSR10.62234342
81TAOK20.61914507
82NUAK10.61668441
83CAMK2B0.60051404
84ROCK20.59903606
85CSNK1D0.59495861
86STK38L0.58866645
87MYLK0.56962360
88CAMK2D0.55023855
89SGK30.54895830
90ILK0.54577786
91WNK10.54406217
92PRKG10.53704265
93NTRK20.51113132
94CAMK2G0.50544392
95CLK10.49888421
96MAP3K40.49711853
97PINK10.49643825
98IRAK40.48451236
99PRKCG0.46628567
100GRK10.45403311
101VRK10.45344542
102ADRBK10.45061961
103BCR0.44019344
104NEK90.43650948
105OBSCN0.43578653
106DMPK0.43042367
107MARK20.42690727
108STK240.42621278
109PTK2B0.41387727
110MINK10.41317067
111PAK60.41201198
112STK110.39833748
113CSNK1G10.39615608
114PRKACA0.38649749
115MAPK40.37803253
116SIK30.37791328
117ATM0.37479767
118TNK20.37205308
119WNK40.36877038
120* MAPK80.36819198
121PRKAA20.36465344
122CDK50.35296700
123TGFBR10.34617232
124STK30.34030298
125RPS6KB10.33592150
126HIPK20.32527920
127ERBB20.32150334
128PLK10.32124429
129RAF10.32042057
130KSR10.31599201
131PRKAA10.31278249
132TGFBR20.31244688
133EIF2AK30.29785098
134GSK3A0.29240313
135IRAK30.28909776
136MAP3K70.28694633
137ERBB40.27397824
138SGK10.26398617
139CSNK1A10.26143450

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005333.67480386
2Nicotine addiction_Homo sapiens_hsa050333.48617086
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.17905126
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.63603356
5Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.61884849
6Fatty acid elongation_Homo sapiens_hsa000622.42546354
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.13287547
8Axon guidance_Homo sapiens_hsa043602.02706534
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.98825751
10Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.93267713
11Phototransduction_Homo sapiens_hsa047441.88812688
12Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.85632124
13Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.85256698
14Morphine addiction_Homo sapiens_hsa050321.78519575
15GABAergic synapse_Homo sapiens_hsa047271.74174360
16Nitrogen metabolism_Homo sapiens_hsa009101.71867005
17Glutamatergic synapse_Homo sapiens_hsa047241.70948032
18Basal cell carcinoma_Homo sapiens_hsa052171.68797874
19Taste transduction_Homo sapiens_hsa047421.58335179
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.49718643
21Circadian entrainment_Homo sapiens_hsa047131.45583110
22Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.44765431
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.43980694
24Wnt signaling pathway_Homo sapiens_hsa043101.42431362
25Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.38518564
26Arachidonic acid metabolism_Homo sapiens_hsa005901.37295626
27Serotonergic synapse_Homo sapiens_hsa047261.35704777
28Hedgehog signaling pathway_Homo sapiens_hsa043401.31891773
29Circadian rhythm_Homo sapiens_hsa047101.31804565
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.30020921
31Basal transcription factors_Homo sapiens_hsa030221.28226500
32Calcium signaling pathway_Homo sapiens_hsa040201.25979340
33Renin secretion_Homo sapiens_hsa049241.24039470
34Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.23771845
35Long-term depression_Homo sapiens_hsa047301.22748403
36Sphingolipid metabolism_Homo sapiens_hsa006001.20312528
37Olfactory transduction_Homo sapiens_hsa047401.17752193
38Ovarian steroidogenesis_Homo sapiens_hsa049131.17543255
39Cholinergic synapse_Homo sapiens_hsa047251.15749837
40Melanogenesis_Homo sapiens_hsa049161.15000570
41Tryptophan metabolism_Homo sapiens_hsa003801.12339558
42Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.10402987
43Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.10192196
44Dilated cardiomyopathy_Homo sapiens_hsa054141.09490556
45ABC transporters_Homo sapiens_hsa020101.05546498
46Melanoma_Homo sapiens_hsa052181.03843147
47Retinol metabolism_Homo sapiens_hsa008301.03665040
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.03522262
49Ether lipid metabolism_Homo sapiens_hsa005651.03398182
50Caffeine metabolism_Homo sapiens_hsa002321.03245807
51Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99881745
52Dorso-ventral axis formation_Homo sapiens_hsa043200.98745806
53Cardiac muscle contraction_Homo sapiens_hsa042600.97560662
54Steroid biosynthesis_Homo sapiens_hsa001000.97557249
55cAMP signaling pathway_Homo sapiens_hsa040240.95923514
56Butanoate metabolism_Homo sapiens_hsa006500.94133912
57Oxidative phosphorylation_Homo sapiens_hsa001900.91992732
58ECM-receptor interaction_Homo sapiens_hsa045120.89407160
59Alzheimers disease_Homo sapiens_hsa050100.88971825
60Protein export_Homo sapiens_hsa030600.88093212
61Salivary secretion_Homo sapiens_hsa049700.85845568
62Lysine degradation_Homo sapiens_hsa003100.85625726
63Non-homologous end-joining_Homo sapiens_hsa034500.85327644
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.82305782
65Fanconi anemia pathway_Homo sapiens_hsa034600.82048895
66Fatty acid biosynthesis_Homo sapiens_hsa000610.81639467
67Aldosterone synthesis and secretion_Homo sapiens_hsa049250.79178702
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78413277
69Insulin secretion_Homo sapiens_hsa049110.77818245
70Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.77449828
71Glycerolipid metabolism_Homo sapiens_hsa005610.77039303
72Chemical carcinogenesis_Homo sapiens_hsa052040.75021722
73Notch signaling pathway_Homo sapiens_hsa043300.74127963
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.73932906
75Prostate cancer_Homo sapiens_hsa052150.73179473
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.73029664
77Vitamin digestion and absorption_Homo sapiens_hsa049770.70471613
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.69686255
79Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.68228607
80Fatty acid metabolism_Homo sapiens_hsa012120.67801453
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.67406764
82Oocyte meiosis_Homo sapiens_hsa041140.66509509
83Homologous recombination_Homo sapiens_hsa034400.64082393
84Maturity onset diabetes of the young_Homo sapiens_hsa049500.62134811
85Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61516385
86Protein digestion and absorption_Homo sapiens_hsa049740.61448825
87Gap junction_Homo sapiens_hsa045400.59891363
88Ras signaling pathway_Homo sapiens_hsa040140.59575609
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.59319477
90PI3K-Akt signaling pathway_Homo sapiens_hsa041510.58430439
91Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.58071641
92Malaria_Homo sapiens_hsa051440.57746669
93Long-term potentiation_Homo sapiens_hsa047200.55937076
94Hippo signaling pathway_Homo sapiens_hsa043900.55439681
95beta-Alanine metabolism_Homo sapiens_hsa004100.53317673
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.53028862
97Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52476416
98Dopaminergic synapse_Homo sapiens_hsa047280.51534165
99Fatty acid degradation_Homo sapiens_hsa000710.51208640
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50913916
101SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50856002
102Parkinsons disease_Homo sapiens_hsa050120.50832195
103Oxytocin signaling pathway_Homo sapiens_hsa049210.50752979
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50101496
105Cocaine addiction_Homo sapiens_hsa050300.50036969
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49638462
107ErbB signaling pathway_Homo sapiens_hsa040120.48000452
108Peroxisome_Homo sapiens_hsa041460.47367986
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46901727
110Histidine metabolism_Homo sapiens_hsa003400.45867265
111Pancreatic secretion_Homo sapiens_hsa049720.45865204
112Amphetamine addiction_Homo sapiens_hsa050310.45683469
113MicroRNAs in cancer_Homo sapiens_hsa052060.45603435
114Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45521058
115Other glycan degradation_Homo sapiens_hsa005110.45231114
116Huntingtons disease_Homo sapiens_hsa050160.44977127
117Thyroid hormone synthesis_Homo sapiens_hsa049180.44890169
118PPAR signaling pathway_Homo sapiens_hsa033200.43738504
119Pathways in cancer_Homo sapiens_hsa052000.42645477
120Gastric acid secretion_Homo sapiens_hsa049710.42526251
121Propanoate metabolism_Homo sapiens_hsa006400.42474298
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41953047
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41659486
124TGF-beta signaling pathway_Homo sapiens_hsa043500.41170585
125Collecting duct acid secretion_Homo sapiens_hsa049660.39914651
126Linoleic acid metabolism_Homo sapiens_hsa005910.39878407
127Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39875984
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38428154
129Mineral absorption_Homo sapiens_hsa049780.38265824

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