NFIB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1limb bud formation (GO:0060174)6.12346326
2regulation of collateral sprouting (GO:0048670)6.09946168
3axonal fasciculation (GO:0007413)5.10458394
4glial cell proliferation (GO:0014009)5.03861835
5cerebral cortex radially oriented cell migration (GO:0021799)5.01861157
6dentate gyrus development (GO:0021542)4.84729521
7positive regulation of male gonad development (GO:2000020)4.78374349
8cornea development in camera-type eye (GO:0061303)4.61431743
9neural tube formation (GO:0001841)4.53559623
10pyrimidine nucleobase catabolic process (GO:0006208)4.53453301
11negative regulation of protein oligomerization (GO:0032460)4.50139420
12keratinocyte development (GO:0003334)4.48849296
13tachykinin receptor signaling pathway (GO:0007217)4.48550388
14neuron cell-cell adhesion (GO:0007158)4.35992749
15neuron recognition (GO:0008038)4.16094125
16regulation of hippo signaling (GO:0035330)4.14147407
17* central nervous system projection neuron axonogenesis (GO:0021952)4.13026687
18negative regulation of astrocyte differentiation (GO:0048712)4.02189750
19positive regulation of action potential (GO:0045760)4.02101312
20negative regulation of axon extension involved in axon guidance (GO:0048843)3.93772734
21spinal cord development (GO:0021510)3.91687153
22regulation of male gonad development (GO:2000018)3.83816532
23long term synaptic depression (GO:0060292)3.81604857
24lateral sprouting from an epithelium (GO:0060601)3.78620527
25presynaptic membrane assembly (GO:0097105)3.72515973
26sympathetic nervous system development (GO:0048485)3.68904679
27serotonin receptor signaling pathway (GO:0007210)3.66638827
28nucleobase catabolic process (GO:0046113)3.65151804
29negative regulation of translation, ncRNA-mediated (GO:0040033)3.62097693
30regulation of translation, ncRNA-mediated (GO:0045974)3.62097693
31negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.62097693
32forebrain neuron differentiation (GO:0021879)3.60547645
33cerebral cortex cell migration (GO:0021795)3.58784101
34positive regulation of vascular permeability (GO:0043117)3.57517878
35inositol phosphate catabolic process (GO:0071545)3.53054576
36G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.51487574
37cardiac ventricle formation (GO:0003211)3.47770940
38DNA double-strand break processing (GO:0000729)3.46200802
39vocalization behavior (GO:0071625)3.44672037
40regulation of axon extension involved in axon guidance (GO:0048841)3.43878109
41negative regulation of axon guidance (GO:1902668)3.41344542
42postsynaptic membrane organization (GO:0001941)3.40972573
43negative regulation of axonogenesis (GO:0050771)3.36728281
44presynaptic membrane organization (GO:0097090)3.35907791
45cardiac chamber formation (GO:0003207)3.34487274
46cell migration in hindbrain (GO:0021535)3.33057381
47neurotransmitter-gated ion channel clustering (GO:0072578)3.32397763
48transmission of nerve impulse (GO:0019226)3.30187957
49cerebellar granule cell differentiation (GO:0021707)3.27511714
50somite development (GO:0061053)3.27453140
51positive regulation of synaptic transmission, GABAergic (GO:0032230)3.18989824
52* central nervous system neuron axonogenesis (GO:0021955)3.17492820
53negative regulation of dendrite development (GO:2000171)3.17322349
54regulation of axon guidance (GO:1902667)3.15823940
55urinary tract smooth muscle contraction (GO:0014848)3.15710800
56negative regulation of keratinocyte proliferation (GO:0010839)3.15626388
57ectoderm development (GO:0007398)3.13604290
58axon extension (GO:0048675)3.11034154
59negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.09251117
60ventricular septum morphogenesis (GO:0060412)3.07686451
61neural crest cell development (GO:0014032)3.07587758
62response to auditory stimulus (GO:0010996)3.07323788
63opioid receptor signaling pathway (GO:0038003)3.03865519
64dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.03728453
65regulation of action potential (GO:0098900)2.98766731
66righting reflex (GO:0060013)2.97843695
67dendrite morphogenesis (GO:0048813)2.94052194
68retinal ganglion cell axon guidance (GO:0031290)2.93358740
69positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.92599876
70olfactory bulb development (GO:0021772)2.92296697
71mitochondrial genome maintenance (GO:0000002)2.91546619
72regulation of axon extension (GO:0030516)2.90526272
73kidney morphogenesis (GO:0060993)2.90350572
74acrosome reaction (GO:0007340)2.88077455
75establishment of mitochondrion localization (GO:0051654)2.87818781
76planar cell polarity pathway involved in neural tube closure (GO:0090179)2.86487074
77lens morphogenesis in camera-type eye (GO:0002089)2.85683681
78behavioral response to ethanol (GO:0048149)2.85279025
79regulation of synapse maturation (GO:0090128)2.85187543
80facial nerve structural organization (GO:0021612)2.85014217
81regulation of keratinocyte proliferation (GO:0010837)2.83953668
82positive regulation of cardiac muscle cell differentiation (GO:2000727)2.83661789
83telencephalon cell migration (GO:0022029)2.82773028
84positive regulation of amino acid transport (GO:0051957)2.81812123
85negative regulation of protein localization to cell surface (GO:2000009)2.81797867
86regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.80614920
87aggressive behavior (GO:0002118)2.78306033
88regulation of glutamate secretion (GO:0014048)2.78284923
89calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.76867554
90regulation of extent of cell growth (GO:0061387)2.76231560
91regulation of short-term neuronal synaptic plasticity (GO:0048172)2.75996601
92protein K11-linked deubiquitination (GO:0035871)2.75557466
93regulation of protein homooligomerization (GO:0032462)2.75063263
94positive regulation of digestive system process (GO:0060456)2.74329789
95ganglion development (GO:0061548)2.74024262
96regulation of telomere maintenance (GO:0032204)2.73619725
97hippocampus development (GO:0021766)2.69617793
98glycosphingolipid biosynthetic process (GO:0006688)2.69551617
99positive regulation of uterine smooth muscle contraction (GO:0070474)2.67835473
100adaptation of signaling pathway (GO:0023058)2.66492157
101positive regulation of synapse assembly (GO:0051965)2.65977342
102negative regulation of transcription regulatory region DNA binding (GO:2000678)2.64934418
103dendrite development (GO:0016358)2.63966019
104forebrain cell migration (GO:0021885)2.63269494
105mitotic sister chromatid cohesion (GO:0007064)2.62624882
106neuronal ion channel clustering (GO:0045161)2.62599793
107axon extension involved in axon guidance (GO:0048846)2.62360186
108neuron projection extension involved in neuron projection guidance (GO:1902284)2.62360186
109lymph vessel development (GO:0001945)2.61952487
110dendritic spine morphogenesis (GO:0060997)2.61704879
111cell differentiation involved in metanephros development (GO:0072202)2.60784688
112glomerulus development (GO:0032835)2.60086456
113regulation of dendritic spine development (GO:0060998)2.59570536
114ionotropic glutamate receptor signaling pathway (GO:0035235)2.59393556
115establishment of planar polarity (GO:0001736)2.59025770
116establishment of tissue polarity (GO:0007164)2.59025770
117neuronal stem cell maintenance (GO:0097150)2.58865237
118positive regulation of sodium ion transmembrane transport (GO:1902307)2.58845316
119proline transport (GO:0015824)2.58473944
120positive regulation of synapse maturation (GO:0090129)2.58266429
121neuron-neuron synaptic transmission (GO:0007270)2.58129144
122neuronal action potential propagation (GO:0019227)2.57776541
123regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.56992146
124anatomical structure arrangement (GO:0048532)2.56392795
125neuron projection extension (GO:1990138)2.55064636
126cranial nerve structural organization (GO:0021604)2.53841600
127regulation of glycogen (starch) synthase activity (GO:2000465)2.53427212
128negative regulation of oligodendrocyte differentiation (GO:0048715)2.53401214
129proximal/distal pattern formation (GO:0009954)2.53119546
130regulation of timing of cell differentiation (GO:0048505)2.52549149
131mesenchymal cell development (GO:0014031)2.51404357
132regulation of NFAT protein import into nucleus (GO:0051532)2.51042425
133startle response (GO:0001964)2.51019228
134morphogenesis of an epithelial sheet (GO:0002011)2.50917432
135regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.49632914
136eyelid development in camera-type eye (GO:0061029)2.48776003
137sequestering of extracellular ligand from receptor (GO:0035581)2.47502983
138negative regulation of glycogen metabolic process (GO:0070874)2.46988741
139cell differentiation involved in kidney development (GO:0061005)2.46929749
140layer formation in cerebral cortex (GO:0021819)2.46727666
141regulation of dendritic spine morphogenesis (GO:0061001)2.44287420
142regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.43543306
143substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.42010637
144substrate-independent telencephalic tangential migration (GO:0021826)2.42010637
145negative regulation of axon extension (GO:0030517)2.41372081
146cochlea morphogenesis (GO:0090103)2.39959863
147cellular response to prostaglandin stimulus (GO:0071379)2.37428908
148negative regulation of glycogen biosynthetic process (GO:0045719)2.37034244
149regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.33231943
150inner ear receptor stereocilium organization (GO:0060122)2.32295059
151regulation of glutamate receptor signaling pathway (GO:1900449)2.31997938
152positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.31668580
153gamma-aminobutyric acid transport (GO:0015812)2.31586095
154glutamate receptor signaling pathway (GO:0007215)2.31149439
155neuron migration (GO:0001764)2.30973451
156regulation of development, heterochronic (GO:0040034)2.30757363
157negative chemotaxis (GO:0050919)2.30705950
158synaptic transmission, glutamatergic (GO:0035249)2.28574502
159regulation of synapse assembly (GO:0051963)2.28169299

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.35946990
2BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.40877012
3GBX2_23144817_ChIP-Seq_PC3_Human3.23172752
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.99280917
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.90047046
6RBPJ_22232070_ChIP-Seq_NCS_Mouse2.47840818
7* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.45599497
8SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.43479100
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.33246941
10RNF2_18974828_ChIP-Seq_MESCs_Mouse2.33246941
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.32186925
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.29989804
13* EZH2_27304074_Chip-Seq_ESCs_Mouse2.27160892
14* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.24523434
15* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.18916191
16* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.17678909
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.15913417
18* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.07860123
19AR_21572438_ChIP-Seq_LNCaP_Human2.05082461
20IGF1R_20145208_ChIP-Seq_DFB_Human2.02156568
21* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.01321425
22* CBX2_27304074_Chip-Seq_ESCs_Mouse1.95530350
23PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.92566110
24* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.91011992
25* RNF2_27304074_Chip-Seq_ESCs_Mouse1.90228784
26PIAS1_25552417_ChIP-Seq_VCAP_Human1.87873803
27* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.81174082
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.80926989
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.75060790
30* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.72807264
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.72543038
32NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.69097975
33* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.68552131
34TAF15_26573619_Chip-Seq_HEK293_Human1.66424548
35* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.65526896
36* P300_19829295_ChIP-Seq_ESCs_Human1.63489351
37TP53_18474530_ChIP-ChIP_U2OS_Human1.61952827
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.60805542
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60317891
40* SMAD4_21799915_ChIP-Seq_A2780_Human1.59209880
41CDX2_19796622_ChIP-Seq_MESCs_Mouse1.59018259
42* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57429120
43OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55785642
44AHR_22903824_ChIP-Seq_MCF-7_Human1.55431321
45IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.54974665
46CBP_20019798_ChIP-Seq_JUKART_Human1.54974665
47* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54159933
48GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.52420004
49SMAD3_21741376_ChIP-Seq_EPCs_Human1.51137463
50ARNT_22903824_ChIP-Seq_MCF-7_Human1.50737302
51POU5F1_16153702_ChIP-ChIP_HESCs_Human1.49219419
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.47501620
53CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.47138991
54* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.46990472
55CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.46903793
56TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.43111813
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.42705859
58TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42042987
59ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41177088
60* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40509972
61BMI1_23680149_ChIP-Seq_NPCS_Mouse1.40484453
62* TP63_19390658_ChIP-ChIP_HaCaT_Human1.39350129
63ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.38656072
64CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38495817
65AR_25329375_ChIP-Seq_VCAP_Human1.37417064
66AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.37215292
67DROSHA_22980978_ChIP-Seq_HELA_Human1.31709810
68RNF2_27304074_Chip-Seq_NSC_Mouse1.31453260
69* NR3C1_21868756_ChIP-Seq_MCF10A_Human1.30621476
70TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.30096047
71POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.30096047
72PRDM14_20953172_ChIP-Seq_ESCs_Human1.29511422
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.29170614
74FUS_26573619_Chip-Seq_HEK293_Human1.27207988
75TP53_16413492_ChIP-PET_HCT116_Human1.27146076
76* RING1B_27294783_Chip-Seq_NPCs_Mouse1.22067332
77* EP300_21415370_ChIP-Seq_HL-1_Mouse1.21887698
78TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.19105742
79* TCF4_22108803_ChIP-Seq_LS180_Human1.18587316
80FLI1_21867929_ChIP-Seq_TH2_Mouse1.18321868
81* SOX2_21211035_ChIP-Seq_LN229_Gbm1.17512507
82WT1_19549856_ChIP-ChIP_CCG9911_Human1.17468979
83STAT3_23295773_ChIP-Seq_U87_Human1.16507799
84TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16223721
85* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16072103
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16047701
87* RUNX2_22187159_ChIP-Seq_PCA_Human1.15911272
88* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.15520967
89* KDM2B_26808549_Chip-Seq_REH_Human1.14473754
90NANOG_18555785_Chip-Seq_ESCs_Mouse1.14323770
91FLI1_27457419_Chip-Seq_LIVER_Mouse1.13899054
92RING1B_27294783_Chip-Seq_ESCs_Mouse1.13602660
93MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.13014338
94* ISL1_27105846_Chip-Seq_CPCs_Mouse1.12500593
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.12110673
96RXR_22108803_ChIP-Seq_LS180_Human1.11734752
97TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.11689345
98TCF4_23295773_ChIP-Seq_U87_Human1.11424556
99* BCAT_22108803_ChIP-Seq_LS180_Human1.10703535
100REST_21632747_ChIP-Seq_MESCs_Mouse1.09911142
101* AR_19668381_ChIP-Seq_PC3_Human1.09134808
102* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08528033
103* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.08315789
104TCF4_18268006_ChIP-ChIP_LS174T_Human1.07211485
105SMAD3_21741376_ChIP-Seq_HESCs_Human1.06913999
106TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.06790024
107EWS_26573619_Chip-Seq_HEK293_Human1.06662833
108ER_23166858_ChIP-Seq_MCF-7_Human1.06078459
109VDR_22108803_ChIP-Seq_LS180_Human1.05864411
110* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.05789804
111KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05499958
112ZNF274_21170338_ChIP-Seq_K562_Hela1.05052982
113* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04556597
114ERG_21242973_ChIP-ChIP_JURKAT_Human1.04511347
115P53_22387025_ChIP-Seq_ESCs_Mouse1.04006924
116TP53_20018659_ChIP-ChIP_R1E_Mouse1.03362013
117PCGF2_27294783_Chip-Seq_ESCs_Mouse1.03282941
118SMAD4_21741376_ChIP-Seq_HESCs_Human1.03196094
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03029518
120* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02983588
121* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02727185
122ESR1_20079471_ChIP-ChIP_T-47D_Human1.02640606
123NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02538421
124NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02538421
125EZH2_27294783_Chip-Seq_NPCs_Mouse1.02389508
126* SOX9_26525672_Chip-Seq_HEART_Mouse1.01842765
127E2F1_18555785_Chip-Seq_ESCs_Mouse0.98832340

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000537_abnormal_urethra_morphology3.00297148
2* MP0000778_abnormal_nervous_system2.89641203
3MP0001529_abnormal_vocalization2.80289429
4MP0003787_abnormal_imprinting2.78092236
5MP0006292_abnormal_olfactory_placode2.36561849
6MP0000566_synostosis2.26842537
7MP0001984_abnormal_olfaction2.25849904
8MP0008789_abnormal_olfactory_epithelium2.17528002
9MP0002837_dystrophic_cardiac_calcinosis2.15458573
10MP0003385_abnormal_body_wall2.13629894
11MP0005171_absent_coat_pigmentation2.08960104
12MP0005394_taste/olfaction_phenotype2.00787103
13MP0005499_abnormal_olfactory_system2.00787103
14MP0004859_abnormal_synaptic_plasticity1.96836606
15MP0002735_abnormal_chemical_nociception1.91601637
16MP0003718_maternal_effect1.89822018
17MP0003755_abnormal_palate_morphology1.89109097
18MP0003880_abnormal_central_pattern1.88158369
19MP0010368_abnormal_lymphatic_system1.87849200
20MP0005551_abnormal_eye_electrophysiolog1.85547454
21MP0000049_abnormal_middle_ear1.80615080
22MP0005257_abnormal_intraocular_pressure1.78779057
23MP0009384_cardiac_valve_regurgitation1.76955368
24MP0002249_abnormal_larynx_morphology1.75941466
25MP0010386_abnormal_urinary_bladder1.75631554
26MP0001188_hyperpigmentation1.75588522
27MP0005503_abnormal_tendon_morphology1.71577414
28MP0002272_abnormal_nervous_system1.68291379
29MP0002233_abnormal_nose_morphology1.65554932
30MP0009250_abnormal_appendicular_skeleto1.65390792
31MP0004885_abnormal_endolymph1.64321964
32MP0002184_abnormal_innervation1.62556003
33MP0008877_abnormal_DNA_methylation1.54042555
34MP0003941_abnormal_skin_development1.53121833
35MP0008872_abnormal_physiological_respon1.48604625
36MP0002234_abnormal_pharynx_morphology1.44424276
37MP0002938_white_spotting1.44082311
38MP0003935_abnormal_craniofacial_develop1.43962325
39MP0001879_abnormal_lymphatic_vessel1.41388732
40MP0002063_abnormal_learning/memory/cond1.40822921
41MP0004134_abnormal_chest_morphology1.37866212
42MP0003635_abnormal_synaptic_transmissio1.37526687
43MP0005646_abnormal_pituitary_gland1.34040090
44MP0003136_yellow_coat_color1.33175221
45MP0009046_muscle_twitch1.32851811
46MP0004043_abnormal_pH_regulation1.32743079
47MP0000762_abnormal_tongue_morphology1.30911474
48MP0008438_abnormal_cutaneous_collagen1.30683318
49MP0009379_abnormal_foot_pigmentation1.30000891
50MP0000534_abnormal_ureter_morphology1.28661816
51MP0001970_abnormal_pain_threshold1.28537920
52MP0009053_abnormal_anal_canal1.26841450
53MP0002116_abnormal_craniofacial_bone1.25789663
54MP0003137_abnormal_impulse_conducting1.23716050
55MP0005275_abnormal_skin_tensile1.23045394
56MP0002572_abnormal_emotion/affect_behav1.22327085
57MP0001486_abnormal_startle_reflex1.21669964
58MP0009745_abnormal_behavioral_response1.20952097
59MP0003121_genomic_imprinting1.20857781
60MP0009780_abnormal_chondrocyte_physiolo1.19168300
61MP0003937_abnormal_limbs/digits/tail_de1.18759456
62MP0003938_abnormal_ear_development1.18737450
63MP0006072_abnormal_retinal_apoptosis1.17717972
64MP0004858_abnormal_nervous_system1.16649789
65MP0005367_renal/urinary_system_phenotyp1.14487388
66MP0000516_abnormal_urinary_system1.14487388
67MP0003942_abnormal_urinary_system1.14333454
68MP0004272_abnormal_basement_membrane1.13740773
69MP0002177_abnormal_outer_ear1.12880722
70MP0002557_abnormal_social/conspecific_i1.11826851
71MP0001501_abnormal_sleep_pattern1.11478034
72MP0002108_abnormal_muscle_morphology1.10047927
73MP0005248_abnormal_Harderian_gland1.08404117
74MP0000631_abnormal_neuroendocrine_gland1.08266786
75MP0000751_myopathy1.07340529
76MP0000647_abnormal_sebaceous_gland1.06267923
77MP0002752_abnormal_somatic_nervous1.05976787
78* MP0001177_atelectasis1.04908123
79MP0002733_abnormal_thermal_nociception1.04818969
80MP0005253_abnormal_eye_physiology1.04081956
81MP0000538_abnormal_urinary_bladder1.03977348
82* MP0003861_abnormal_nervous_system1.03856505
83MP0002736_abnormal_nociception_after1.02709163
84MP0000569_abnormal_digit_pigmentation1.01904039
85MP0006276_abnormal_autonomic_nervous1.01152380
86MP0002822_catalepsy1.00774956
87MP0000955_abnormal_spinal_cord0.99786850
88MP0000428_abnormal_craniofacial_morphol0.99353936
89MP0004270_analgesia0.98931592
90MP0010030_abnormal_orbit_morphology0.98170884
91MP0004215_abnormal_myocardial_fiber0.97821527
92MP0000579_abnormal_nail_morphology0.97661363
93MP0000015_abnormal_ear_pigmentation0.97458103
94MP0000678_abnormal_parathyroid_gland0.96828127
95MP0005395_other_phenotype0.95843444
96MP0005409_darkened_coat_color0.94217113
97MP0000432_abnormal_head_morphology0.92467250
98MP0000026_abnormal_inner_ear0.91955618
99MP0005195_abnormal_posterior_eye0.91560282
100MP0010234_abnormal_vibrissa_follicle0.91434879
101MP0003567_abnormal_fetal_cardiomyocyte0.90116818
102* MP0002152_abnormal_brain_morphology0.89922570
103MP0002653_abnormal_ependyma_morphology0.89314234
104MP0002067_abnormal_sensory_capabilities0.88947401
105MP0001968_abnormal_touch/_nociception0.88725300
106MP0004085_abnormal_heartbeat0.88510704
107MP0002277_abnormal_respiratory_mucosa0.88436942
108MP0003633_abnormal_nervous_system0.87750589
109MP0004742_abnormal_vestibular_system0.87540522
110MP0002066_abnormal_motor_capabilities/c0.86972420
111MP0005386_behavior/neurological_phenoty0.86945446
112MP0004924_abnormal_behavior0.86945446
113MP0002734_abnormal_mechanical_nocicepti0.86479590
114MP0003119_abnormal_digestive_system0.85557761
115MP0006138_congestive_heart_failure0.85487496
116MP0002882_abnormal_neuron_morphology0.85020352
117MP0002064_seizures0.84107841
118MP0004811_abnormal_neuron_physiology0.83425137
119* MP0002081_perinatal_lethality0.82744886
120MP0005620_abnormal_muscle_contractility0.81150716
121MP0001485_abnormal_pinna_reflex0.80641616
122MP0000427_abnormal_hair_cycle0.79883707
123MP0003631_nervous_system_phenotype0.79822392
124MP0001299_abnormal_eye_distance/0.79477038
125MP0005187_abnormal_penis_morphology0.78599154
126MP0002751_abnormal_autonomic_nervous0.78454500
127MP0008770_decreased_survivor_rate0.78434887
128MP0000372_irregular_coat_pigmentation0.77895663
129MP0002102_abnormal_ear_morphology0.75646534
130MP0002932_abnormal_joint_morphology0.75079600
131MP0003698_abnormal_male_reproductive0.74317198
132MP0003122_maternal_imprinting0.73603591
133MP0008569_lethality_at_weaning0.72542386
134MP0002282_abnormal_trachea_morphology0.70880071
135MP0002928_abnormal_bile_duct0.67804841
136MP0003632_abnormal_nervous_system0.65820495
137MP0002069_abnormal_eating/drinking_beha0.65288477
138MP0009703_decreased_birth_body0.60882132

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)5.09253042
2Focal seizures (HP:0007359)4.44741939
3Megalencephaly (HP:0001355)3.52220960
4Shallow orbits (HP:0000586)3.50398348
5Abnormality of the labia minora (HP:0012880)3.26946587
6Obstructive sleep apnea (HP:0002870)3.24072176
7Abnormality of the heme biosynthetic pathway (HP:0010472)3.19671874
8Hepatoblastoma (HP:0002884)3.01555687
9Retinal dysplasia (HP:0007973)2.98792159
10Overgrowth (HP:0001548)2.88079989
11Chronic hepatic failure (HP:0100626)2.86607573
12Long clavicles (HP:0000890)2.84116301
13Astrocytoma (HP:0009592)2.83765852
14Abnormality of the astrocytes (HP:0100707)2.83765852
15Abnormal social behavior (HP:0012433)2.82027244
16Impaired social interactions (HP:0000735)2.82027244
17Amyotrophic lateral sclerosis (HP:0007354)2.77085736
18Ependymoma (HP:0002888)2.76192701
19Lymphangioma (HP:0100764)2.68043361
20Protruding tongue (HP:0010808)2.67836432
21Hemiparesis (HP:0001269)2.59962609
22Thickened helices (HP:0000391)2.57035212
23Poor eye contact (HP:0000817)2.54300139
24Action tremor (HP:0002345)2.51384125
25True hermaphroditism (HP:0010459)2.50650013
26Morphological abnormality of the middle ear (HP:0008609)2.49295160
27Volvulus (HP:0002580)2.47458792
28Glioma (HP:0009733)2.45196026
29Nephronophthisis (HP:0000090)2.45089551
30Pancreatic cysts (HP:0001737)2.45049626
31Pancreatic fibrosis (HP:0100732)2.42933453
32Germ cell neoplasia (HP:0100728)2.41973770
33Fair hair (HP:0002286)2.40908223
34Absent speech (HP:0001344)2.40273015
35Abnormality of the nasal septum (HP:0000419)2.39392204
36Generalized tonic-clonic seizures (HP:0002069)2.36095152
37Dialeptic seizures (HP:0011146)2.35944800
38Shoulder girdle muscle weakness (HP:0003547)2.32136449
39Febrile seizures (HP:0002373)2.30367360
40Focal motor seizures (HP:0011153)2.29542640
41Abnormality of midbrain morphology (HP:0002418)2.27280954
42Molar tooth sign on MRI (HP:0002419)2.27280954
43Neoplasm of the adrenal cortex (HP:0100641)2.27229776
44Tubulointerstitial nephritis (HP:0001970)2.26628301
45Progressive cerebellar ataxia (HP:0002073)2.26233304
46Bell-shaped thorax (HP:0001591)2.24565589
47Abnormality of the intervertebral disk (HP:0005108)2.24463579
48Broad-based gait (HP:0002136)2.24140698
49Sleep apnea (HP:0010535)2.23422051
50Aplasia/Hypoplasia of the sternum (HP:0006714)2.23063705
51Blue irides (HP:0000635)2.21897196
52Cutaneous finger syndactyly (HP:0010554)2.20914943
53Inappropriate behavior (HP:0000719)2.20898962
54Intestinal atresia (HP:0011100)2.19977518
55Short chin (HP:0000331)2.17539343
56Abnormality of the antihelix (HP:0009738)2.17015924
57Abnormality of incisor morphology (HP:0011063)2.16686298
58Lissencephaly (HP:0001339)2.16570388
59Exotropia (HP:0000577)2.15505954
60Abnormality of the renal medulla (HP:0100957)2.15256700
61Advanced eruption of teeth (HP:0006288)2.14206685
62Cupped ear (HP:0000378)2.13148435
63Aplasia cutis congenita (HP:0001057)2.10613343
64Inability to walk (HP:0002540)2.09497507
65Abnormality of the nasolacrimal system (HP:0000614)2.08493013
66Abnormality of the pubic bones (HP:0003172)2.06575493
67Narrow forehead (HP:0000341)2.05050741
68Short 4th metacarpal (HP:0010044)2.04626634
69Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.04626634
70Genital tract atresia (HP:0001827)2.04248144
71Hamartoma of the eye (HP:0010568)2.03830718
72Drooling (HP:0002307)2.02690264
73Excessive salivation (HP:0003781)2.02690264
74Midline defect of the nose (HP:0004122)2.00291744
75Atonic seizures (HP:0010819)1.99845869
76Prolonged QT interval (HP:0001657)1.99731046
77Asymmetry of the thorax (HP:0001555)1.99669595
78Gastroesophageal reflux (HP:0002020)1.99645058
79Aqueductal stenosis (HP:0002410)1.99499434
80Pachygyria (HP:0001302)1.97462334
81Congenital stationary night blindness (HP:0007642)1.96700859
82Abnormal hair whorl (HP:0010721)1.96642641
83Wide cranial sutures (HP:0010537)1.95053371
84Cutaneous syndactyly (HP:0012725)1.94314987
85Fibular hypoplasia (HP:0003038)1.94100394
86Rimmed vacuoles (HP:0003805)1.93585943
87Coronal craniosynostosis (HP:0004440)1.93351009
88Tented upper lip vermilion (HP:0010804)1.92852122
89Thyroiditis (HP:0100646)1.92221088
90Aplasia/Hypoplasia of the uvula (HP:0010293)1.91523024
91Bronchomalacia (HP:0002780)1.89631582
92Skull defect (HP:0001362)1.89534316
93Aplasia involving bones of the upper limbs (HP:0009823)1.89287049
94Aplasia of the phalanges of the hand (HP:0009802)1.89287049
95Aplasia involving bones of the extremities (HP:0009825)1.89287049
96Abnormality of the 4th metacarpal (HP:0010012)1.88669420
97Gait imbalance (HP:0002141)1.88133881
98Vaginal atresia (HP:0000148)1.87690221
99Intellectual disability, severe (HP:0010864)1.87347881
100Palpebral edema (HP:0100540)1.85572582
101Intellectual disability, moderate (HP:0002342)1.85505988
102Optic nerve hypoplasia (HP:0000609)1.84705002
103Abnormality of the lacrimal duct (HP:0011481)1.84691747
104Hypoproteinemia (HP:0003075)1.83502471
105Type II lissencephaly (HP:0007260)1.81920522
106Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.81540940
107Hypoplastic nipples (HP:0002557)1.80940167
108Progressive sensorineural hearing impairment (HP:0000408)1.80195105
109Absent eyebrow (HP:0002223)1.80091649
110Abnormality of the calf musculature (HP:0001430)1.79915163
111Cutis marmorata (HP:0000965)1.79517546
112Anencephaly (HP:0002323)1.78376704
113Alacrima (HP:0000522)1.77471856
114Nasolacrimal duct obstruction (HP:0000579)1.77126502
115Neoplasm of the heart (HP:0100544)1.76439164
116Hypoplastic labia majora (HP:0000059)1.76278245
117Intellectual disability, progressive (HP:0006887)1.75254858
118Abnormality of hair growth rate (HP:0011363)1.74770734
119Slow-growing hair (HP:0002217)1.74770734
120Open mouth (HP:0000194)1.74664150
121Postaxial hand polydactyly (HP:0001162)1.73790020
122Anophthalmia (HP:0000528)1.71881383
123Shawl scrotum (HP:0000049)1.71200544
124Widely spaced teeth (HP:0000687)1.71198668
125Submucous cleft hard palate (HP:0000176)1.71146670
126Generalized hypopigmentation of hair (HP:0011358)1.70986713
127Myelomeningocele (HP:0002475)1.70945012
128Laryngomalacia (HP:0001601)1.70482906
129Polymicrogyria (HP:0002126)1.69339610
130Cystic liver disease (HP:0006706)1.68999495
131Wide anterior fontanel (HP:0000260)1.68716926
132Choanal stenosis (HP:0000452)1.68601127
133Epileptic encephalopathy (HP:0200134)1.68574026
134Abnormality of the right ventricle (HP:0001707)1.68125927
135Hypochromic microcytic anemia (HP:0004840)1.67926417
136Stomach cancer (HP:0012126)1.67620969
137Facial hemangioma (HP:0000329)1.67487813
138Sclerocornea (HP:0000647)1.67133120
139Accelerated skeletal maturation (HP:0005616)1.66101229
140Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.65826491
141Short 1st metacarpal (HP:0010034)1.65826491
142Keratoconus (HP:0000563)1.64722769
143Increased corneal curvature (HP:0100692)1.64722769
144Widely patent fontanelles and sutures (HP:0004492)1.64636630
145Labial hypoplasia (HP:0000066)1.64114128
146Amblyopia (HP:0000646)1.62242203
147Abnormality of the aortic arch (HP:0012303)1.61572989
148Meningioma (HP:0002858)1.60409897
149Renal hypoplasia (HP:0000089)1.60155956
150Preauricular pit (HP:0004467)1.59615785
151Periauricular skin pits (HP:0100277)1.59615785
152Right ventricular cardiomyopathy (HP:0011663)1.58075485
153Abnormality of the axillary hair (HP:0100134)1.57872993
154Abnormality of secondary sexual hair (HP:0009888)1.57872993
155Abnormality of salivation (HP:0100755)1.57821863
156Tracheomalacia (HP:0002779)1.57258142
157Omphalocele (HP:0001539)1.57068925
158Double outlet right ventricle (HP:0001719)1.55598419
159Congenital malformation of the right heart (HP:0011723)1.55598419
160Gaze-evoked nystagmus (HP:0000640)1.55499740
161Neonatal hypoglycemia (HP:0001998)1.54902569
162Narrow nasal bridge (HP:0000446)1.54582243
163Exercise-induced myalgia (HP:0003738)1.54444112
164Insulin-resistant diabetes mellitus (HP:0000831)1.54274270
165Overfolded helix (HP:0000396)1.52131835
166Abnormality of the labia majora (HP:0012881)1.51869752
167Papillary thyroid carcinoma (HP:0002895)1.50866636

Predicted kinase interactions (KEA)

RankGene SetZ-score
1WNK35.00426503
2CASK4.17924281
3MARK13.75392838
4EPHA43.67680333
5EPHB22.87051862
6EPHA32.65244038
7SGK22.60535107
8MAP3K42.55345066
9MAP2K72.47746340
10CCNB12.45152343
11PRPF4B2.44359905
12YES12.27682840
13SGK4942.02252039
14SGK2232.02252039
15TAOK21.85376716
16SGK31.79796491
17AKT31.74166293
18ERBB31.71645803
19MAPK131.69522061
20TNIK1.64074539
21FGFR21.63282979
22NTRK31.61007623
23PLK21.56494467
24MAP4K21.55639328
25DYRK21.52220442
26ZAK1.50439786
27LATS11.49610591
28STK38L1.46387484
29TAOK11.41614218
30BCR1.38691857
31BMPR1B1.33768248
32TRIM281.33493092
33NTRK21.33143109
34MKNK21.24744147
35PAK61.22345410
36INSRR1.22273257
37KSR11.21076457
38PIK3CA1.15248585
39PHKG21.12458366
40PHKG11.12458366
41ERBB41.11995681
42STK241.10916302
43MAP2K41.07764434
44ROCK11.02236308
45FRK0.98159336
46DMPK0.97151331
47PRKCH0.97111757
48PKN10.97091124
49CAMK1G0.96324252
50SIK10.93003699
51DAPK20.91100968
52PRKCE0.91073244
53FER0.90049560
54PINK10.87042346
55IRAK20.83854247
56PDGFRA0.82223208
57CAMK40.82209718
58TIE10.81227103
59SIK30.80450950
60CSNK1G20.76051313
61ROCK20.73707559
62PLK40.73680403
63ADRBK20.72945726
64SGK10.72133551
65PRKCG0.71584451
66CAMK2A0.69999706
67MINK10.68765496
68CSNK1D0.68730321
69IRAK10.68624831
70CAMKK20.67741374
71DYRK1A0.66409195
72MKNK10.66064551
73PNCK0.65698783
74EIF2AK20.65430547
75MAP2K10.65234976
76CSNK1G30.64916524
77CDK50.64176720
78VRK10.63395210
79CSNK1A1L0.61607385
80BMPR20.61040111
81EIF2AK30.59631199
82PAK30.59601149
83GRK10.58637311
84CSNK1A10.57917792
85PTK2B0.57240690
86CDK30.56620077
87BRSK20.56405243
88NUAK10.55661707
89CSNK1G10.54762700
90DDR20.53606648
91ILK0.53244686
92CAMK2B0.52139957
93RPS6KA20.51509325
94PLK30.50935092
95LMTK20.50110046
96CAMK10.49787373
97NEK60.48893790
98* MAPK80.47513098
99GRK50.47136309
100WEE10.47080513
101PRKCZ0.46066240
102WNK10.44997651
103MYLK0.44656566
104CAMK1D0.42578738
105OBSCN0.42537745
106GSK3A0.41958129
107SRPK10.40974034
108RPS6KB10.40236685
109CDK180.39354149
110FGFR10.39264091
111RPS6KA30.38637128
112ADRBK10.37867435
113LATS20.36027815
114SIK20.35489732
115CDK150.35269095
116TTN0.34889775
117PRKG10.33550160
118CAMK2G0.33090815
119BRD40.32660005
120TYRO30.32543049
121ERBB20.32533118
122STK390.31513302
123CAMK2D0.31270961
124PRKCB0.31153642
125PRKAA10.30636023
126MAPK40.30589320
127PRKACA0.30527141
128MAPK100.30303179
129MARK20.30073110
130TGFBR20.29883164
131GSK3B0.29867799
132UHMK10.29841424
133MAP3K60.29153294
134CDK140.29142719
135STK110.28160484

Predicted pathways (KEGG)

RankGene SetZ-score
1Axon guidance_Homo sapiens_hsa043602.78205663
2Taste transduction_Homo sapiens_hsa047422.50800760
3Nicotine addiction_Homo sapiens_hsa050332.50565552
4Steroid biosynthesis_Homo sapiens_hsa001002.31203053
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.28490816
6Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.22106032
7Non-homologous end-joining_Homo sapiens_hsa034502.17244842
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.92777571
9Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.90282781
10Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.88480809
11Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.88081898
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.86214083
13Circadian entrainment_Homo sapiens_hsa047131.73403761
14Glutamatergic synapse_Homo sapiens_hsa047241.72671474
15Basal cell carcinoma_Homo sapiens_hsa052171.65765206
16Serotonergic synapse_Homo sapiens_hsa047261.64472596
17Fanconi anemia pathway_Homo sapiens_hsa034601.64427738
18Olfactory transduction_Homo sapiens_hsa047401.62222384
19Morphine addiction_Homo sapiens_hsa050321.56283209
20GABAergic synapse_Homo sapiens_hsa047271.51871737
21Butanoate metabolism_Homo sapiens_hsa006501.46367082
22Dilated cardiomyopathy_Homo sapiens_hsa054141.42909541
23Renin secretion_Homo sapiens_hsa049241.40434632
24Wnt signaling pathway_Homo sapiens_hsa043101.36499296
25Dopaminergic synapse_Homo sapiens_hsa047281.36104115
26Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.32519399
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.32490917
28Adherens junction_Homo sapiens_hsa045201.32039261
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.30177516
30Amphetamine addiction_Homo sapiens_hsa050311.28336728
31Hippo signaling pathway_Homo sapiens_hsa043901.25717079
32ErbB signaling pathway_Homo sapiens_hsa040121.25141192
33Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.24863210
34Hedgehog signaling pathway_Homo sapiens_hsa043401.24320777
35Endometrial cancer_Homo sapiens_hsa052131.23854127
36Melanogenesis_Homo sapiens_hsa049161.21178012
37Long-term depression_Homo sapiens_hsa047301.18338898
38Fatty acid metabolism_Homo sapiens_hsa012121.17510811
39Calcium signaling pathway_Homo sapiens_hsa040201.17076866
40Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.14915589
41Cholinergic synapse_Homo sapiens_hsa047251.13677573
42Long-term potentiation_Homo sapiens_hsa047201.12810683
43cAMP signaling pathway_Homo sapiens_hsa040241.09821257
44Melanoma_Homo sapiens_hsa052181.09379582
45ABC transporters_Homo sapiens_hsa020101.08193896
46Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.07265129
47Ether lipid metabolism_Homo sapiens_hsa005651.06174587
48Tight junction_Homo sapiens_hsa045301.04803195
49Linoleic acid metabolism_Homo sapiens_hsa005911.04675761
50ECM-receptor interaction_Homo sapiens_hsa045121.04554749
51Colorectal cancer_Homo sapiens_hsa052101.01020560
52Lysine degradation_Homo sapiens_hsa003101.00360118
53Caffeine metabolism_Homo sapiens_hsa002321.00177564
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98648248
55Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.98454871
56Steroid hormone biosynthesis_Homo sapiens_hsa001400.96307584
57Aldosterone synthesis and secretion_Homo sapiens_hsa049250.96197449
58Gastric acid secretion_Homo sapiens_hsa049710.95591576
59Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.95158867
60Propanoate metabolism_Homo sapiens_hsa006400.93744321
61Fatty acid degradation_Homo sapiens_hsa000710.92842673
62mTOR signaling pathway_Homo sapiens_hsa041500.92808915
63PPAR signaling pathway_Homo sapiens_hsa033200.91876535
64beta-Alanine metabolism_Homo sapiens_hsa004100.90850361
65Rap1 signaling pathway_Homo sapiens_hsa040150.90807173
66Basal transcription factors_Homo sapiens_hsa030220.90028783
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89223038
68GnRH signaling pathway_Homo sapiens_hsa049120.89121416
69Focal adhesion_Homo sapiens_hsa045100.88979087
70Cocaine addiction_Homo sapiens_hsa050300.88371120
71Insulin secretion_Homo sapiens_hsa049110.83923212
72Fatty acid biosynthesis_Homo sapiens_hsa000610.83659607
73Salivary secretion_Homo sapiens_hsa049700.83438667
74Notch signaling pathway_Homo sapiens_hsa043300.82596745
75Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.82491112
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82266147
77Prostate cancer_Homo sapiens_hsa052150.80602334
78Ovarian steroidogenesis_Homo sapiens_hsa049130.79024863
79Gap junction_Homo sapiens_hsa045400.78754474
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76922077
81Retinol metabolism_Homo sapiens_hsa008300.76416402
82Oxytocin signaling pathway_Homo sapiens_hsa049210.76410345
83Ras signaling pathway_Homo sapiens_hsa040140.74604290
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73653681
85Glioma_Homo sapiens_hsa052140.72637284
86TGF-beta signaling pathway_Homo sapiens_hsa043500.71110594
87alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.70764095
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.70448618
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.68326968
90Phototransduction_Homo sapiens_hsa047440.67698166
91Type II diabetes mellitus_Homo sapiens_hsa049300.67615622
92Choline metabolism in cancer_Homo sapiens_hsa052310.66069014
93Tryptophan metabolism_Homo sapiens_hsa003800.64702128
94MAPK signaling pathway_Homo sapiens_hsa040100.64480778
95Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.59639175
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.59551321
97Fatty acid elongation_Homo sapiens_hsa000620.58361008
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.57620386
99Viral myocarditis_Homo sapiens_hsa054160.56216320
100AMPK signaling pathway_Homo sapiens_hsa041520.55756368
101Chemical carcinogenesis_Homo sapiens_hsa052040.54472216
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.53893571
103Nitrogen metabolism_Homo sapiens_hsa009100.53796316
104Insulin resistance_Homo sapiens_hsa049310.53175685
105Thyroid hormone signaling pathway_Homo sapiens_hsa049190.52254128
106Pathways in cancer_Homo sapiens_hsa052000.52105737
107PI3K-Akt signaling pathway_Homo sapiens_hsa041510.51895734
108Oocyte meiosis_Homo sapiens_hsa041140.50915323
109Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.50542240
110MicroRNAs in cancer_Homo sapiens_hsa052060.50069368
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49020956
112Estrogen signaling pathway_Homo sapiens_hsa049150.48664768
113Dorso-ventral axis formation_Homo sapiens_hsa043200.47846390
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47172129
115Primary bile acid biosynthesis_Homo sapiens_hsa001200.47076266
116Homologous recombination_Homo sapiens_hsa034400.47068384
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46802613
118Protein digestion and absorption_Homo sapiens_hsa049740.46243132
119Synaptic vesicle cycle_Homo sapiens_hsa047210.46104598
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46090157
121FoxO signaling pathway_Homo sapiens_hsa040680.43483344
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43428737
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43129889
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.42487398
125Insulin signaling pathway_Homo sapiens_hsa049100.42449788
126African trypanosomiasis_Homo sapiens_hsa051430.42128190
127Pancreatic secretion_Homo sapiens_hsa049720.39783767
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.39552383
129Glucagon signaling pathway_Homo sapiens_hsa049220.38157375

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