NFIC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the CTF/NF-I family. These are dimeric DNA-binding proteins, and function as cellular transcription factors and as replication factors for adenovirus DNA replication. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane repair (GO:0001778)4.60854201
2endothelial cell chemotaxis (GO:0035767)3.62196585
3sarcomere organization (GO:0045214)3.58964276
4muscle filament sliding (GO:0030049)3.58937562
5actin-myosin filament sliding (GO:0033275)3.58937562
6positive regulation of fatty acid beta-oxidation (GO:0032000)3.49362090
7carnitine shuttle (GO:0006853)3.48616726
8synaptic vesicle docking involved in exocytosis (GO:0016081)3.48575268
9regulation of skeletal muscle contraction (GO:0014819)3.34140380
10fatty acid transmembrane transport (GO:1902001)3.28715938
11lysine catabolic process (GO:0006554)3.26916801
12lysine metabolic process (GO:0006553)3.26916801
13L-phenylalanine metabolic process (GO:0006558)3.26856096
14erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.26856096
15L-phenylalanine catabolic process (GO:0006559)3.22986610
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.22986610
17alpha-linolenic acid metabolic process (GO:0036109)3.22912994
18cardiac myofibril assembly (GO:0055003)3.22631682
19positive regulation of fatty acid oxidation (GO:0046321)3.16485097
20myofibril assembly (GO:0030239)3.11942934
21adherens junction assembly (GO:0034333)3.09637202
22insulin-like growth factor receptor signaling pathway (GO:0048009)3.08530545
23regulation of fatty acid beta-oxidation (GO:0031998)3.08438925
24regulation of fatty acid oxidation (GO:0046320)3.07131479
25positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.03157346
262-oxoglutarate metabolic process (GO:0006103)3.02364447
27cell-substrate junction assembly (GO:0007044)3.00801495
28cell-substrate adherens junction assembly (GO:0007045)3.00601816
29focal adhesion assembly (GO:0048041)3.00601816
30actin-mediated cell contraction (GO:0070252)3.00531278
31cell migration involved in heart development (GO:0060973)2.98430816
32extracellular matrix assembly (GO:0085029)2.93742873
33fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.91120096
34regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.86429349
35myelination in peripheral nervous system (GO:0022011)2.82875685
36peripheral nervous system axon ensheathment (GO:0032292)2.82875685
37aspartate family amino acid catabolic process (GO:0009068)2.82455478
38fatty acid beta-oxidation (GO:0006635)2.82372379
39regulation of cholesterol homeostasis (GO:2000188)2.81952307
40cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.80571149
41protein carboxylation (GO:0018214)2.77932828
42peptidyl-glutamic acid carboxylation (GO:0017187)2.77932828
43creatine metabolic process (GO:0006600)2.77831813
44negative regulation of fatty acid transport (GO:2000192)2.75093548
45atrioventricular valve morphogenesis (GO:0003181)2.74798762
46cellular potassium ion homeostasis (GO:0030007)2.74342500
47desmosome organization (GO:0002934)2.72607476
48regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.71905609
49sodium ion export (GO:0071436)2.71004809
50negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.70977919
51basement membrane organization (GO:0071711)2.69161226
52negative regulation of potassium ion transmembrane transport (GO:1901380)2.69100324
53sarcoplasmic reticulum calcium ion transport (GO:0070296)2.68812294
54regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.67631406
55semaphorin-plexin signaling pathway (GO:0071526)2.67223545
56regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.65627193
57negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.65138412
58carnitine transmembrane transport (GO:1902603)2.63165139
59regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.62157971
60glyoxylate metabolic process (GO:0046487)2.62035368
61protein heterotrimerization (GO:0070208)2.61886835
62regulation of tight junction assembly (GO:2000810)2.61879470
63actomyosin structure organization (GO:0031032)2.61803443
64cardiac muscle contraction (GO:0060048)2.61249386
65negative regulation of cell size (GO:0045792)2.57114685
66fatty acid oxidation (GO:0019395)2.56406228
67vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.55974915
68positive regulation of synapse maturation (GO:0090129)2.55750387
69fatty acid catabolic process (GO:0009062)2.54652713
70carnitine transport (GO:0015879)2.53719811
71amino-acid betaine transport (GO:0015838)2.53719811
72cell volume homeostasis (GO:0006884)2.53602714
73negative regulation of fibrinolysis (GO:0051918)2.52115203
74lipid oxidation (GO:0034440)2.52061119
75response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.51748286
76regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.51637549
77cerebellar granule cell differentiation (GO:0021707)2.51221605
78skin morphogenesis (GO:0043589)2.50976785
79amino-acid betaine metabolic process (GO:0006577)2.50696421
80positive regulation of glycogen biosynthetic process (GO:0045725)2.50530864
81positive regulation of blood vessel endothelial cell migration (GO:0043536)2.49376526
82regulation of the force of heart contraction (GO:0002026)2.49282953
83triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.47880882
84positive regulation of triglyceride biosynthetic process (GO:0010867)2.47220293
85complement activation, alternative pathway (GO:0006957)2.47110311
86glycogen catabolic process (GO:0005980)2.47062442
87cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.46913176
88actin filament-based movement (GO:0030048)2.46232574
89kynurenine metabolic process (GO:0070189)2.45932219
90positive regulation of lipid catabolic process (GO:0050996)2.45450430
91tricarboxylic acid metabolic process (GO:0072350)2.45395404
92venous blood vessel morphogenesis (GO:0048845)2.43998632
93positive regulation of receptor recycling (GO:0001921)2.43856778
94heart trabecula formation (GO:0060347)2.43766748
95membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.43560735
96aromatic amino acid family catabolic process (GO:0009074)2.43390712
97regulation of p38MAPK cascade (GO:1900744)2.43309471
98peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.43259633
99bundle of His cell to Purkinje myocyte communication (GO:0086069)2.42029484
100regulation of sequestering of triglyceride (GO:0010889)2.41830451
101carnitine metabolic process (GO:0009437)2.39505309
102valine metabolic process (GO:0006573)2.39219173
103monocarboxylic acid catabolic process (GO:0072329)2.38965764
104protein targeting to plasma membrane (GO:0072661)2.38856601
105cellular ketone body metabolic process (GO:0046950)2.38544037
106planar cell polarity pathway involved in neural tube closure (GO:0090179)2.38457477
107regulation of actin filament-based movement (GO:1903115)2.38312898
108dicarboxylic acid biosynthetic process (GO:0043650)2.37811210
109regulation of triglyceride catabolic process (GO:0010896)2.37401426
110response to mercury ion (GO:0046689)2.37260252
111short-chain fatty acid metabolic process (GO:0046459)2.37245359
112positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.37087832
113barbed-end actin filament capping (GO:0051016)2.36922921
114apoptotic cell clearance (GO:0043277)2.35512637
115negative regulation of protein localization to cell surface (GO:2000009)2.34742174
116positive regulation of glycogen metabolic process (GO:0070875)2.34609050
117stress fiber assembly (GO:0043149)2.34583461
118sulfur amino acid catabolic process (GO:0000098)2.34166791
119tooth mineralization (GO:0034505)2.34099267
120kidney mesenchyme development (GO:0072074)2.34021902
121positive regulation of triglyceride metabolic process (GO:0090208)2.32784606
122positive regulation of fatty acid metabolic process (GO:0045923)2.32769154
123cellular modified amino acid catabolic process (GO:0042219)2.31827483
124striated muscle contraction (GO:0006941)2.31697220
125glucan catabolic process (GO:0009251)2.31576857
126cell communication involved in cardiac conduction (GO:0086065)2.30237901
127bile acid biosynthetic process (GO:0006699)2.29953824
128acetyl-CoA metabolic process (GO:0006084)2.28698789
129regulation of protein activation cascade (GO:2000257)2.28695881
1304-hydroxyproline metabolic process (GO:0019471)2.28285301
131regulation of triglyceride biosynthetic process (GO:0010866)2.28060511
132endothelial cell morphogenesis (GO:0001886)2.27197168
133regulation of glucose import in response to insulin stimulus (GO:2001273)2.26110524
134positive regulation of histone deacetylation (GO:0031065)2.26037939
135positive regulation of myotube differentiation (GO:0010831)2.26019594
136vascular endothelial growth factor signaling pathway (GO:0038084)2.25647210
137regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.24445421
138negative regulation of catenin import into nucleus (GO:0035414)2.24256259
139quaternary ammonium group transport (GO:0015697)2.23216563
140cell communication by electrical coupling (GO:0010644)2.22875750
141regulation of complement activation (GO:0030449)2.22821473
142adhesion of symbiont to host (GO:0044406)2.22646085
143glutamate secretion (GO:0014047)2.22497616
144regulation of early endosome to late endosome transport (GO:2000641)2.22454901
145cytoskeletal anchoring at plasma membrane (GO:0007016)2.22333069
146regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.22052334
147activation of protein kinase A activity (GO:0034199)2.21204482
148ethanol oxidation (GO:0006069)2.20798972
149ventricular cardiac muscle cell action potential (GO:0086005)2.20200015
150regulation of fibrinolysis (GO:0051917)2.20139203
151oxaloacetate metabolic process (GO:0006107)2.20113266
152hemidesmosome assembly (GO:0031581)2.19193842
153camera-type eye morphogenesis (GO:0048593)2.18949417
154protein localization to endosome (GO:0036010)2.18635921
155actin filament depolymerization (GO:0030042)2.18317578
156skeletal muscle fiber development (GO:0048741)2.17009566
157regulation of integrin-mediated signaling pathway (GO:2001044)2.16500795
158metanephric nephron epithelium development (GO:0072243)2.16161330
159regulation of synapse maturation (GO:0090128)2.15972495
160extracellular fibril organization (GO:0043206)2.15542556
161neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.15288215
162positive regulation of extracellular matrix organization (GO:1903055)2.14831320
163regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.14376023
164metanephric mesenchyme development (GO:0072075)2.13734118
165collagen fibril organization (GO:0030199)2.12463942
166cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.11772482
167cellular response to epinephrine stimulus (GO:0071872)2.11324085
168metanephric nephron tubule development (GO:0072234)2.08893933
169metanephric tubule development (GO:0072170)2.08893933
170muscle contraction (GO:0006936)2.05751691
171regulation of endothelial cell chemotaxis (GO:2001026)2.03541675
172cell-cell junction maintenance (GO:0045217)2.03416775
173endocardial cushion development (GO:0003197)2.02703675

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.46047170
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.91277215
3* RXR_22158963_ChIP-Seq_LIVER_Mouse3.34703516
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.00177103
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.92294816
6LXR_22158963_ChIP-Seq_LIVER_Mouse2.79198896
7NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.39543727
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.32983129
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.27235525
10TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13554831
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.08861562
12CLOCK_20551151_ChIP-Seq_293T_Human2.03521742
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.02469439
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.01285304
15* ESR2_21235772_ChIP-Seq_MCF-7_Human1.92557637
16TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.84886311
17EP300_21415370_ChIP-Seq_HL-1_Mouse1.84011286
18ESR1_20079471_ChIP-ChIP_T-47D_Human1.78726136
19PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.77169165
20ZNF263_19887448_ChIP-Seq_K562_Human1.76049401
21* TBX20_22080862_ChIP-Seq_HEART_Mouse1.75409498
22* TBX20_22328084_ChIP-Seq_HEART_Mouse1.75409498
23LXR_22292898_ChIP-Seq_THP-1_Human1.73822344
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.63145089
25* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.60249554
26TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.59946672
27TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.59310638
28RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.45596496
29DROSHA_22980978_ChIP-Seq_HELA_Human1.45248099
30* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41383177
31ELK3_25401928_ChIP-Seq_HUVEC_Human1.40433239
32* KDM2B_26808549_Chip-Seq_K562_Human1.39917831
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.37814972
34* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.36654389
35NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34725534
36GATA2_21666600_ChIP-Seq_HMVEC_Human1.34409876
37RACK7_27058665_Chip-Seq_MCF-7_Human1.34396010
38ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.33646002
39* TP53_23651856_ChIP-Seq_MEFs_Mouse1.33592717
40MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33505111
41EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.33442805
42FOXA2_19822575_ChIP-Seq_HepG2_Human1.33396268
43EZH2_22144423_ChIP-Seq_EOC_Human1.32428964
44RNF2_27304074_Chip-Seq_ESCs_Mouse1.32345472
45* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.31889998
46* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.31889998
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30732215
48MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30142921
49* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.29594562
50TET1_21490601_ChIP-Seq_MESCs_Mouse1.27753170
51* KDM2B_26808549_Chip-Seq_DND41_Human1.25942224
52BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.24008801
53* P68_20966046_ChIP-Seq_HELA_Human1.21125303
54ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.20538939
55* ESR1_21235772_ChIP-Seq_MCF-7_Human1.19832370
56CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19577705
57SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.19410434
58SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18314340
59RARB_27405468_Chip-Seq_BRAIN_Mouse1.17998411
60DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16032982
61CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14909190
62SMC3_22415368_ChIP-Seq_MEFs_Mouse1.14637540
63SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.14040754
64* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.13656832
65TET1_21451524_ChIP-Seq_MESCs_Mouse1.12794478
66P300_27058665_Chip-Seq_ZR-75-30cells_Human1.12330423
67* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.11736154
68VDR_21846776_ChIP-Seq_THP-1_Human1.11689193
69JARID2_20075857_ChIP-Seq_MESCs_Mouse1.11130311
70TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.09758165
71* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09709006
72TP53_22127205_ChIP-Seq_IMR90_Human1.09604640
73* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09425959
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.09022500
75* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08031972
76CJUN_26792858_Chip-Seq_BT549_Human1.06698884
77KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.06686227
78SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.06640221
79JARID2_20064375_ChIP-Seq_MESCs_Mouse1.06230775
80CTCF_27219007_Chip-Seq_Bcells_Human1.05737961
81EZH2_27294783_Chip-Seq_ESCs_Mouse1.05708942
82SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05114827
83EZH2_27304074_Chip-Seq_ESCs_Mouse1.05067512
84HIF1A_21447827_ChIP-Seq_MCF-7_Human1.05059385
85PPAR_26484153_Chip-Seq_NCI-H1993_Human1.04785585
86* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03707959
87SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.03156909
88ERG_21242973_ChIP-ChIP_JURKAT_Human1.02518397
89* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02422304
90NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02271993
91NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02271993
92GATA1_19941826_ChIP-Seq_K562_Human1.01320644
93NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99297068
94* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.98751500
95TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.98342391
96* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.96633236
97KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96399734
98SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.96325609
99CREB1_26743006_Chip-Seq_LNCaP_Human0.95654252
100* KDM2B_26808549_Chip-Seq_JURKAT_Human0.94784370
101SMC1_22415368_ChIP-Seq_MEFs_Mouse0.93990591
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.93931661
103SUZ12_27294783_Chip-Seq_ESCs_Mouse0.93835797
104P63_26484246_Chip-Seq_KERATINOCYTES_Human0.92795015
105FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.91310095
106EGR1_23403033_ChIP-Seq_LIVER_Mouse0.90615174
107ZNF217_24962896_ChIP-Seq_MCF-7_Human0.90499823
108* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.90343295
109TP63_22573176_ChIP-Seq_HFKS_Human0.89497951
110* EED_16625203_ChIP-ChIP_MESCs_Mouse0.89135919
111FOXO3_23340844_ChIP-Seq_DLD1_Human0.88409372
112ATF3_27146783_Chip-Seq_COLON_Human0.86891977
113* TCF7_22412390_ChIP-Seq_EML_Mouse0.86351667
114RUNX1_27514584_Chip-Seq_MCF-7_Human0.85432505
115* TP53_20018659_ChIP-ChIP_R1E_Mouse0.85348685
116* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.83790399
117* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82991609
118SA1_27219007_Chip-Seq_ERYTHROID_Human0.81272907
119SMC4_20622854_ChIP-Seq_HELA_Human0.80050979
120* GATA2_19941826_ChIP-Seq_K562_Human0.79983540
121* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.79971777

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis4.00259986
2MP0000751_myopathy3.84207435
3MP0008438_abnormal_cutaneous_collagen3.54734245
4MP0000749_muscle_degeneration3.05648683
5MP0003705_abnormal_hypodermis_morpholog2.89515221
6MP0002139_abnormal_hepatobiliary_system2.72912479
7MP0004084_abnormal_cardiac_muscle2.52912783
8MP0004036_abnormal_muscle_relaxation2.46768357
9MP0004145_abnormal_muscle_electrophysio2.45447413
10MP0005275_abnormal_skin_tensile2.44598845
11MP0003646_muscle_fatigue2.41999252
12MP0005360_urolithiasis2.38697729
13MP0004130_abnormal_muscle_cell2.20586115
14MP0003279_aneurysm2.19202935
15MP0004087_abnormal_muscle_fiber2.17952540
16MP0005409_darkened_coat_color2.16962666
17MP0005503_abnormal_tendon_morphology2.16146966
18MP0005365_abnormal_bile_salt2.11763502
19MP0005085_abnormal_gallbladder_physiolo2.11133415
20MP0000747_muscle_weakness2.09310053
21MP0010368_abnormal_lymphatic_system1.99758710
22MP0005330_cardiomyopathy1.98273308
23MP0000750_abnormal_muscle_regeneration1.91828946
24MP0005083_abnormal_biliary_tract1.89433043
25MP0003252_abnormal_bile_duct1.88118197
26MP0000759_abnormal_skeletal_muscle1.82544135
27MP0002269_muscular_atrophy1.79289849
28MP0002249_abnormal_larynx_morphology1.72836764
29MP0002106_abnormal_muscle_physiology1.70741435
30MP0005670_abnormal_white_adipose1.66702900
31MP0004215_abnormal_myocardial_fiber1.63169418
32MP0002108_abnormal_muscle_morphology1.62972736
33MP0005369_muscle_phenotype1.62222300
34MP0005620_abnormal_muscle_contractility1.61628416
35MP0009840_abnormal_foam_cell1.58761478
36MP0001958_emphysema1.56217785
37MP0003879_abnormal_hair_cell1.56025065
38MP0008875_abnormal_xenobiotic_pharmacok1.53745761
39MP0004510_myositis1.53122801
40MP0005257_abnormal_intraocular_pressure1.53106454
41MP0005076_abnormal_cell_differentiation1.52187995
42MP0003195_calcinosis1.51939200
43MP0010329_abnormal_lipoprotein_level1.49087981
44MP0006138_congestive_heart_failure1.49053889
45MP0001849_ear_inflammation1.49032895
46MP0004272_abnormal_basement_membrane1.48395716
47MP0002972_abnormal_cardiac_muscle1.47218927
48MP0004859_abnormal_synaptic_plasticity1.44656891
49MP0010630_abnormal_cardiac_muscle1.44448414
50MP0000678_abnormal_parathyroid_gland1.43978554
51MP0005623_abnormal_meninges_morphology1.43481372
52MP0005666_abnormal_adipose_tissue1.42987807
53MP0001348_abnormal_lacrimal_gland1.42152632
54MP0000013_abnormal_adipose_tissue1.38096854
55MP0001544_abnormal_cardiovascular_syste1.33837002
56MP0005385_cardiovascular_system_phenoty1.33837002
57MP0005375_adipose_tissue_phenotype1.28160928
58MP0004233_abnormal_muscle_weight1.27597269
59MP0000733_abnormal_muscle_development1.26133435
60MP0003566_abnormal_cell_adhesion1.24731040
61MP0005332_abnormal_amino_acid1.24089909
62MP0003950_abnormal_plasma_membrane1.22339452
63MP0005451_abnormal_body_composition1.20280737
64MP0002118_abnormal_lipid_homeostasis1.17161265
65MP0009384_cardiac_valve_regurgitation1.14124663
66MP0003806_abnormal_nucleotide_metabolis1.11457537
67MP0003300_gastrointestinal_ulcer1.11014709
68MP0008775_abnormal_heart_ventricle1.10644719
69MP0004185_abnormal_adipocyte_glucose1.10285880
70MP0003137_abnormal_impulse_conducting1.10039760
71MP0003045_fibrosis1.09785764
72MP0000003_abnormal_adipose_tissue1.07299089
73MP0009780_abnormal_chondrocyte_physiolo1.06633150
74MP0000534_abnormal_ureter_morphology1.06199397
75MP0002060_abnormal_skin_morphology1.03146199
76MP0002896_abnormal_bone_mineralization0.99989093
77MP0004484_altered_response_of0.99048170
78MP0002971_abnormal_brown_adipose0.96992834
79MP0001502_abnormal_circadian_rhythm0.96490056
80MP0003191_abnormal_cellular_cholesterol0.96233036
81MP0005319_abnormal_enzyme/_coenzyme0.95431145
82MP0004085_abnormal_heartbeat0.94353946
83MP0004858_abnormal_nervous_system0.94063930
84MP0002877_abnormal_melanocyte_morpholog0.92120679
85MP0000767_abnormal_smooth_muscle0.90873951
86MP0003828_pulmonary_edema0.89807656
87MP0001542_abnormal_bone_strength0.88539016
88MP0001879_abnormal_lymphatic_vessel0.87224773
89MP0008961_abnormal_basal_metabolism0.86242880
90MP0008569_lethality_at_weaning0.86016623
91MP0002128_abnormal_blood_circulation0.85872683
92MP0005058_abnormal_lysosome_morphology0.85107851
93MP0002332_abnormal_exercise_endurance0.84873251
94MP0009250_abnormal_appendicular_skeleto0.83463063
95MP0002909_abnormal_adrenal_gland0.82682833
96MP0005584_abnormal_enzyme/coenzyme_acti0.82612714
97MP0002168_other_aberrant_phenotype0.81591939
98MP0001661_extended_life_span0.81522684
99MP0010030_abnormal_orbit_morphology0.80490556
100MP0002234_abnormal_pharynx_morphology0.80343069
101MP0000467_abnormal_esophagus_morphology0.78988160
102MP0002933_joint_inflammation0.78525935
103MP0000230_abnormal_systemic_arterial0.77120328
104MP0000163_abnormal_cartilage_morphology0.76742160
105MP0001666_abnormal_nutrient_absorption0.76686130
106MP0005023_abnormal_wound_healing0.76605054
107MP0000609_abnormal_liver_physiology0.76231745
108MP0002295_abnormal_pulmonary_circulatio0.75097119
109MP0000762_abnormal_tongue_morphology0.74481597
110MP0005508_abnormal_skeleton_morphology0.74233255
111MP0001299_abnormal_eye_distance/0.73363910
112MP0003329_amyloid_beta_deposits0.72991081
113MP0000681_abnormal_thyroid_gland0.72837053
114MP0005165_increased_susceptibility_to0.71193721
115MP0001270_distended_abdomen0.71097180
116MP0009643_abnormal_urine_homeostasis0.70316781
117MP0000343_altered_response_to0.70127827
118MP0003091_abnormal_cell_migration0.69492269
119MP0006036_abnormal_mitochondrial_physio0.69452345
120MP0004270_analgesia0.67666202
121MP0000579_abnormal_nail_morphology0.67322431
122MP0002078_abnormal_glucose_homeostasis0.66081365
123MP0003075_altered_response_to0.65919415
124MP0003453_abnormal_keratinocyte_physiol0.63454501
125MP0005334_abnormal_fat_pad0.63166158
126MP0003011_delayed_dark_adaptation0.63044582
127MP0000266_abnormal_heart_morphology0.62450864
128MP0003172_abnormal_lysosome_physiology0.62443761
129MP0002998_abnormal_bone_remodeling0.61887229
130MP0004043_abnormal_pH_regulation0.61654474
131MP0005595_abnormal_vascular_smooth0.61181002
132MP0003283_abnormal_digestive_organ0.61144460
133MP0003942_abnormal_urinary_system0.60953025
134MP0004134_abnormal_chest_morphology0.60203756
135MP0002970_abnormal_white_adipose0.58790844
136MP0000462_abnormal_digestive_system0.57632878

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)4.71089794
2Type 1 muscle fiber predominance (HP:0003803)4.47344217
3Increased connective tissue (HP:0009025)4.24532579
4Protrusio acetabuli (HP:0003179)4.18899686
5Hyporeflexia of lower limbs (HP:0002600)4.11327394
6Exercise-induced myalgia (HP:0003738)4.06668093
7Muscle fiber splitting (HP:0003555)4.03586357
8Sudden death (HP:0001699)3.72539098
9Exercise-induced muscle cramps (HP:0003710)3.66891907
10Broad metatarsal (HP:0001783)3.64751315
11Premature rupture of membranes (HP:0001788)3.57947131
12Calf muscle hypertrophy (HP:0008981)3.41717040
13Increased variability in muscle fiber diameter (HP:0003557)3.35641337
14Difficulty running (HP:0009046)3.33920575
15Muscle hypertrophy of the lower extremities (HP:0008968)3.33707674
16Abnormality of the calf musculature (HP:0001430)3.21736340
17Muscle fiber inclusion bodies (HP:0100299)3.19173442
18Deep venous thrombosis (HP:0002625)3.17116198
19Myoglobinuria (HP:0002913)3.15059748
20Abnormality of skeletal muscle fiber size (HP:0012084)3.13685322
21Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.13548117
22EMG: myopathic abnormalities (HP:0003458)3.11245734
23Myotonia (HP:0002486)3.03318409
24Ventricular tachycardia (HP:0004756)2.97679111
25Asymmetric septal hypertrophy (HP:0001670)2.97205522
26Right ventricular cardiomyopathy (HP:0011663)2.96401022
27Spinal rigidity (HP:0003306)2.80356083
28Difficulty climbing stairs (HP:0003551)2.79831310
29Xanthomatosis (HP:0000991)2.79600991
30Round ear (HP:0100830)2.79076429
31Mildly elevated creatine phosphokinase (HP:0008180)2.74606695
32Centrally nucleated skeletal muscle fibers (HP:0003687)2.72031041
33Shallow orbits (HP:0000586)2.69379855
34Ankle contracture (HP:0006466)2.63323510
35Distal arthrogryposis (HP:0005684)2.61694397
36Abnormality of the left ventricular outflow tract (HP:0011103)2.59017106
37Subaortic stenosis (HP:0001682)2.59017106
38Muscle stiffness (HP:0003552)2.57167499
39Broad face (HP:0000283)2.51156216
40Lipoatrophy (HP:0100578)2.50935915
41Nemaline bodies (HP:0003798)2.50452899
42Ketosis (HP:0001946)2.44572195
43Vascular tortuosity (HP:0004948)2.43348821
44Ketoacidosis (HP:0001993)2.42621907
45Cerebral aneurysm (HP:0004944)2.41898281
46Abnormality of aromatic amino acid family metabolism (HP:0004338)2.41504509
47Abnormality of the Achilles tendon (HP:0005109)2.41473660
48Atrial fibrillation (HP:0005110)2.40799920
49Fragile skin (HP:0001030)2.38917109
50Cervical subluxation (HP:0003308)2.35575231
51Hypoglycemic coma (HP:0001325)2.34522071
52Wormian bones (HP:0002645)2.33338137
53Hyperacusis (HP:0010780)2.31293226
54Achilles tendon contracture (HP:0001771)2.31095983
55Bundle branch block (HP:0011710)2.27400199
56Atrophic scars (HP:0001075)2.24460420
57Peritonitis (HP:0002586)2.24140608
58Overgrowth (HP:0001548)2.23849657
59Lower limb amyotrophy (HP:0007210)2.22008370
60Primary atrial arrhythmia (HP:0001692)2.20169314
61Complement deficiency (HP:0004431)2.19121508
62Vertebral compression fractures (HP:0002953)2.15664698
63Arterial tortuosity (HP:0005116)2.14763469
64Dilated cardiomyopathy (HP:0001644)2.14549707
65Ulnar bowing (HP:0003031)2.13939675
66Abnormal atrioventricular conduction (HP:0005150)2.13581182
67Mitral regurgitation (HP:0001653)2.13337268
68Advanced eruption of teeth (HP:0006288)2.13198616
69Hypoalphalipoproteinemia (HP:0003233)2.12749263
70Slender build (HP:0001533)2.11221876
71Limb-girdle muscle atrophy (HP:0003797)2.11088498
72Scapular winging (HP:0003691)2.11049935
73Stridor (HP:0010307)2.10653109
74Aortic dissection (HP:0002647)2.08098873
75Supraventricular arrhythmia (HP:0005115)2.06488910
76Follicular hyperkeratosis (HP:0007502)2.06330553
77Distal lower limb muscle weakness (HP:0009053)2.06036131
78Supraventricular tachycardia (HP:0004755)2.05720330
79Atrioventricular block (HP:0001678)2.05694632
80Rhabdomyolysis (HP:0003201)2.04998634
81Blue sclerae (HP:0000592)2.04298849
82Lymphangioma (HP:0100764)2.04298554
83Intrahepatic cholestasis (HP:0001406)2.03242464
84Prolonged QT interval (HP:0001657)2.00985629
85Hyperlipoproteinemia (HP:0010980)2.00094134
86Distal lower limb amyotrophy (HP:0008944)1.99841629
87Myopathic facies (HP:0002058)1.99706349
88Heart block (HP:0012722)1.99312489
89Bladder diverticulum (HP:0000015)1.98462363
90Wrist flexion contracture (HP:0001239)1.97825316
91Joint stiffness (HP:0001387)1.97504504
92Generalized amyotrophy (HP:0003700)1.95573615
93Aortic regurgitation (HP:0001659)1.95534303
94Distal upper limb amyotrophy (HP:0007149)1.94797656
95Upper limb amyotrophy (HP:0009129)1.94797656
96Hyperammonemia (HP:0001987)1.93723398
97Abnormality of fatty-acid metabolism (HP:0004359)1.92704879
98Ventricular arrhythmia (HP:0004308)1.92427803
99Neonatal short-limb short stature (HP:0008921)1.92361520
100Aneurysm (HP:0002617)1.92354320
101Bulbar palsy (HP:0001283)1.91373410
102Mitral valve prolapse (HP:0001634)1.90794375
103Natal tooth (HP:0000695)1.90735677
104Skin nodule (HP:0200036)1.86666889
105Palpitations (HP:0001962)1.85034509
106Sparse lateral eyebrow (HP:0005338)1.81558073
107Syncope (HP:0001279)1.81552208
108Reduced subcutaneous adipose tissue (HP:0003758)1.80437440
109Joint laxity (HP:0001388)1.79842129
110Venous abnormality (HP:0002624)1.79623809
111Abnormality of complement system (HP:0005339)1.79543804
112Hip contracture (HP:0003273)1.79184315
113Osteolytic defects of the hand bones (HP:0009699)1.78182663
114Osteolytic defects of the phalanges of the hand (HP:0009771)1.78182663
115Ulnar deviation of the wrist (HP:0003049)1.77402195
116Acanthosis nigricans (HP:0000956)1.77328827
117Axonal loss (HP:0003447)1.75807862
118Soft skin (HP:0000977)1.75475603
119Biconcave vertebral bodies (HP:0004586)1.75329746
120Late onset (HP:0003584)1.75181531
121Turricephaly (HP:0000262)1.74813847
122Aortic aneurysm (HP:0004942)1.74765127
123Ventricular fibrillation (HP:0001663)1.74660135
124Cholelithiasis (HP:0001081)1.74550744
125Dilatation of the ascending aorta (HP:0005111)1.74109810
126EMG: neuropathic changes (HP:0003445)1.73913313
127Hypoventilation (HP:0002791)1.73884665
128Hyperextensible skin (HP:0000974)1.73293932
129Genu recurvatum (HP:0002816)1.73257638
130Mitral stenosis (HP:0001718)1.72808583
131Bradycardia (HP:0001662)1.72430585
132Abnormality of monocarboxylic acid metabolism (HP:0010996)1.71705295
133Hypoplastic ischia (HP:0003175)1.71061226
134Gout (HP:0001997)1.70488927
135Dysmetric saccades (HP:0000641)1.69787333
136Gowers sign (HP:0003391)1.69372723
137Abnormality of the ischium (HP:0003174)1.68764079
138Elbow flexion contracture (HP:0002987)1.67975885
139Neck muscle weakness (HP:0000467)1.66948643
140Abnormality of the common coagulation pathway (HP:0010990)1.65899435
141Infantile muscular hypotonia (HP:0008947)1.62767503
142Bronchomalacia (HP:0002780)1.62204570
143Limited hip movement (HP:0008800)1.62182552
144Disproportionate tall stature (HP:0001519)1.61826543
145Foot dorsiflexor weakness (HP:0009027)1.61662980

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.59495750
2TTN4.00941980
3SIK12.82751053
4ERN12.79296397
5PKN22.74764587
6TIE12.54772398
7BCKDK2.48893345
8PHKG22.34926543
9PHKG12.34926543
10RIPK12.24882220
11EPHB12.11155925
12OBSCN2.04555064
13LMTK22.03969086
14DMPK1.77627450
15TESK11.71142778
16PRPF4B1.69433282
17PDGFRA1.59797878
18CDK121.58377052
19AKT31.50328630
20PTK61.43328565
21MYLK1.41311288
22MAP3K71.39160388
23EPHA21.38749706
24SMG11.37695027
25DDR21.36858209
26MAP2K31.36755682
27PIK3CG1.34886637
28TGFBR21.30499768
29BMX1.28094408
30FGFR41.26832526
31CAMK1G1.26353892
32PIK3CA1.23041370
33CAMK1D1.21724999
34PINK11.20733718
35NTRK11.19889951
36EPHA31.17968928
37LATS21.16081983
38WNK11.13049038
39EEF2K1.10467266
40FER1.08302684
41WNK41.08211218
42MAPKAPK31.07878416
43PRKD31.06794089
44PRKD11.05804269
45MAP3K61.05458980
46INSRR1.01701309
47TRPM70.99578369
48RET0.96499215
49LATS10.93040558
50PTK20.92637684
51LIMK10.92012182
52MAPK70.90060663
53MUSK0.89521574
54CAMKK10.89338116
55MAPK120.89318740
56STK380.89032697
57MARK10.88767374
58EPHB20.88732833
59FLT30.88669580
60PRKCH0.88020863
61IRAK30.87449893
62ILK0.86203548
63PAK30.84855859
64ICK0.82328555
65MAP3K10.81234887
66MAP2K40.81103718
67NTRK30.81032929
68LRRK20.80069605
69TAOK10.78687030
70ROCK10.77685685
71PAK60.76716963
72PTK2B0.73192579
73NEK90.70793060
74PRKD20.69591651
75PRKAA20.69286271
76PAK20.68611456
77RPS6KL10.67888387
78RPS6KC10.67888387
79MAP2K10.67413536
80TNK20.67208636
81MTOR0.66375972
82PDPK10.65812488
83MOS0.65572791
84MET0.65488158
85PDK40.65266000
86PDK30.65266000
87PRKG20.64269719
88MAP3K130.62595943
89MST1R0.59883215
90ROCK20.59588522
91MAPK40.58719402
92TAOK20.58173694
93ABL20.58071420
94CAMKK20.57024921
95KDR0.56678088
96CAMK2D0.56398254
97CAMK40.56060341
98JAK10.55847378
99CAMK2B0.55043145
100RPS6KA60.54608640
101DYRK1B0.53389044
102DAPK20.53251915
103SGK2230.52814655
104SGK4940.52814655
105CDC42BPA0.52181752
106NEK10.51210085
107MAP3K30.51114700
108CAMK10.50321242
109ARAF0.48995311
110MAPK150.48649022
111PRKAA10.48515708
112SGK30.48478357
113MARK20.47919984
114CAMK2G0.47684448
115DAPK30.47633620
116HIPK20.46579426
117RPS6KA20.46240559
118MAPK110.45602347
119SGK20.45425940
120MAPK100.43946383
121MAP3K20.43687743
122PDGFRB0.43224226
123MAP2K20.41913484
124MAPKAPK50.40421666
125KSR20.38413241
126PAK40.38370472
127MAP3K100.34736828

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.04912013
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.81800683
3Fatty acid degradation_Homo sapiens_hsa000712.50092655
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.23425370
52-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.22178539
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.18817774
7Arginine biosynthesis_Homo sapiens_hsa002202.09473617
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.09308428
9Propanoate metabolism_Homo sapiens_hsa006402.02708018
10Fatty acid metabolism_Homo sapiens_hsa012121.94322462
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.82398338
12Dilated cardiomyopathy_Homo sapiens_hsa054141.80840568
13PPAR signaling pathway_Homo sapiens_hsa033201.79860821
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.77181589
15Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.77114009
16Tryptophan metabolism_Homo sapiens_hsa003801.76270459
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.69653023
18Butanoate metabolism_Homo sapiens_hsa006501.63406402
19Complement and coagulation cascades_Homo sapiens_hsa046101.53717402
20Bile secretion_Homo sapiens_hsa049761.47662027
21Starch and sucrose metabolism_Homo sapiens_hsa005001.42337260
22Long-term potentiation_Homo sapiens_hsa047201.40612745
23Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.36877132
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.35741719
25Notch signaling pathway_Homo sapiens_hsa043301.28333764
26Glycosaminoglycan degradation_Homo sapiens_hsa005311.28149777
27Pyruvate metabolism_Homo sapiens_hsa006201.23176662
28ECM-receptor interaction_Homo sapiens_hsa045121.21517890
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.20892324
30Carbon metabolism_Homo sapiens_hsa012001.18849125
31Glioma_Homo sapiens_hsa052141.18384385
32Fatty acid elongation_Homo sapiens_hsa000621.16271665
33Thyroid hormone signaling pathway_Homo sapiens_hsa049191.14309988
34Circadian rhythm_Homo sapiens_hsa047101.12874411
35Insulin resistance_Homo sapiens_hsa049311.12663186
36Peroxisome_Homo sapiens_hsa041461.09478266
37Phospholipase D signaling pathway_Homo sapiens_hsa040721.08867723
38beta-Alanine metabolism_Homo sapiens_hsa004101.07474921
39Lysine degradation_Homo sapiens_hsa003101.07132117
40Calcium signaling pathway_Homo sapiens_hsa040201.07019802
41Circadian entrainment_Homo sapiens_hsa047131.06557240
42Focal adhesion_Homo sapiens_hsa045101.04167558
43Caffeine metabolism_Homo sapiens_hsa002321.02225912
44Cardiac muscle contraction_Homo sapiens_hsa042601.01608599
45Melanogenesis_Homo sapiens_hsa049161.01383688
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.01042413
47Amphetamine addiction_Homo sapiens_hsa050311.00495637
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.99900090
49VEGF signaling pathway_Homo sapiens_hsa043700.99032324
50Adipocytokine signaling pathway_Homo sapiens_hsa049200.97255523
51Pentose and glucuronate interconversions_Homo sapiens_hsa000400.97161243
52mTOR signaling pathway_Homo sapiens_hsa041500.96252435
53Phenylalanine metabolism_Homo sapiens_hsa003600.94732967
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94243147
55Amoebiasis_Homo sapiens_hsa051460.89516522
56Cocaine addiction_Homo sapiens_hsa050300.89359260
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.88084053
58Staphylococcus aureus infection_Homo sapiens_hsa051500.88035487
59Histidine metabolism_Homo sapiens_hsa003400.87102426
60Cholinergic synapse_Homo sapiens_hsa047250.86544406
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86242835
62Glucagon signaling pathway_Homo sapiens_hsa049220.85969835
63Protein digestion and absorption_Homo sapiens_hsa049740.84796234
64Synaptic vesicle cycle_Homo sapiens_hsa047210.83906239
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.82752588
66Insulin signaling pathway_Homo sapiens_hsa049100.81925435
67Renal cell carcinoma_Homo sapiens_hsa052110.81897392
68Biosynthesis of amino acids_Homo sapiens_hsa012300.80081607
69Glutamatergic synapse_Homo sapiens_hsa047240.79288693
70Chronic myeloid leukemia_Homo sapiens_hsa052200.78822208
71Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78809240
72Gap junction_Homo sapiens_hsa045400.78557772
73ABC transporters_Homo sapiens_hsa020100.78537062
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.76939952
75Arginine and proline metabolism_Homo sapiens_hsa003300.76406606
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.75946972
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75820170
78Aldosterone synthesis and secretion_Homo sapiens_hsa049250.75540645
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.74523126
80Tyrosine metabolism_Homo sapiens_hsa003500.74399433
81Tight junction_Homo sapiens_hsa045300.73937481
82Chemical carcinogenesis_Homo sapiens_hsa052040.72737473
83Vitamin B6 metabolism_Homo sapiens_hsa007500.72588996
84Bladder cancer_Homo sapiens_hsa052190.70683957
85AMPK signaling pathway_Homo sapiens_hsa041520.70217513
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69291643
87Fructose and mannose metabolism_Homo sapiens_hsa000510.69177735
88Phosphatidylinositol signaling system_Homo sapiens_hsa040700.68737016
89Fat digestion and absorption_Homo sapiens_hsa049750.68500909
90Other glycan degradation_Homo sapiens_hsa005110.68072083
91Sulfur metabolism_Homo sapiens_hsa009200.68008234
92MAPK signaling pathway_Homo sapiens_hsa040100.67234242
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.67210089
94ErbB signaling pathway_Homo sapiens_hsa040120.67175083
95Choline metabolism in cancer_Homo sapiens_hsa052310.66621621
96Fatty acid biosynthesis_Homo sapiens_hsa000610.65289870
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64878418
98Dopaminergic synapse_Homo sapiens_hsa047280.64294882
99Acute myeloid leukemia_Homo sapiens_hsa052210.63238721
100Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.63164045
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62468356
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.62342207
103Gastric acid secretion_Homo sapiens_hsa049710.60055268
104Proteoglycans in cancer_Homo sapiens_hsa052050.59000729
105Rap1 signaling pathway_Homo sapiens_hsa040150.58509889
106Axon guidance_Homo sapiens_hsa043600.58467981
107Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57503592
108Endocytosis_Homo sapiens_hsa041440.56048119
109Insulin secretion_Homo sapiens_hsa049110.56022830
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.54968376
111Melanoma_Homo sapiens_hsa052180.54689893
112cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54621940
113GABAergic synapse_Homo sapiens_hsa047270.54250658
114Endometrial cancer_Homo sapiens_hsa052130.53341870
115Glycerolipid metabolism_Homo sapiens_hsa005610.53081730
116Inositol phosphate metabolism_Homo sapiens_hsa005620.52970343
117Prostate cancer_Homo sapiens_hsa052150.52584104
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.52325472
119Cyanoamino acid metabolism_Homo sapiens_hsa004600.52040561
120Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50624376
121Central carbon metabolism in cancer_Homo sapiens_hsa052300.50480709
122Type II diabetes mellitus_Homo sapiens_hsa049300.47804029
123Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47679166
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.45863917
125AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45118386
126Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44930488
127Platelet activation_Homo sapiens_hsa046110.44670659
128Ovarian steroidogenesis_Homo sapiens_hsa049130.44375177
129Retinol metabolism_Homo sapiens_hsa008300.44010784
130Prion diseases_Homo sapiens_hsa050200.43539298
131Oxytocin signaling pathway_Homo sapiens_hsa049210.43164939
132Renin secretion_Homo sapiens_hsa049240.42214633
133Galactose metabolism_Homo sapiens_hsa000520.41375674
134Pancreatic secretion_Homo sapiens_hsa049720.40714525
135GnRH signaling pathway_Homo sapiens_hsa049120.38750294
136Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37721819
137Thyroid hormone synthesis_Homo sapiens_hsa049180.37145739
138Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36839909
139Estrogen signaling pathway_Homo sapiens_hsa049150.33695556
140Viral myocarditis_Homo sapiens_hsa054160.32392816
141Dorso-ventral axis formation_Homo sapiens_hsa043200.31494054
142cAMP signaling pathway_Homo sapiens_hsa040240.30645028
143Salivary secretion_Homo sapiens_hsa049700.30566393
144Adherens junction_Homo sapiens_hsa045200.29453039
145Selenocompound metabolism_Homo sapiens_hsa004500.28130196

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