NFIX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transcription factor that binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3 in viral and cellular promoters. The encoded protein can also stimulate adenovirus replication in vitro. Three transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1layer formation in cerebral cortex (GO:0021819)4.21988381
2pyrimidine nucleobase catabolic process (GO:0006208)4.16141531
3vocalization behavior (GO:0071625)4.09285726
4locomotory exploration behavior (GO:0035641)4.04155822
5cellular potassium ion homeostasis (GO:0030007)3.87466552
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.83474378
7positive regulation of synapse maturation (GO:0090129)3.74026558
8nucleobase catabolic process (GO:0046113)3.60508637
9central nervous system projection neuron axonogenesis (GO:0021952)3.60179387
10synaptic vesicle maturation (GO:0016188)3.52177325
11dendritic spine morphogenesis (GO:0060997)3.52034875
12plasma membrane repair (GO:0001778)3.51730662
13positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.48880089
14axonal fasciculation (GO:0007413)3.48128343
15dendrite morphogenesis (GO:0048813)3.47650528
16regulation of glutamate receptor signaling pathway (GO:1900449)3.32002473
17regulation of synapse structural plasticity (GO:0051823)3.29402737
18synaptic vesicle docking involved in exocytosis (GO:0016081)3.28709180
19regulation of short-term neuronal synaptic plasticity (GO:0048172)3.26440188
20exploration behavior (GO:0035640)3.23001475
21glutamate secretion (GO:0014047)3.21450903
22neuron recognition (GO:0008038)3.20012754
23postsynaptic membrane organization (GO:0001941)3.19832841
24cerebral cortex radially oriented cell migration (GO:0021799)3.18222477
25neurotransmitter-gated ion channel clustering (GO:0072578)3.17068362
26cell migration in hindbrain (GO:0021535)3.13629256
27protein localization to synapse (GO:0035418)3.13447534
28neuron cell-cell adhesion (GO:0007158)3.06230158
29dermatan sulfate metabolic process (GO:0030205)3.04770374
30dermatan sulfate biosynthetic process (GO:0030208)3.01724234
31axon extension (GO:0048675)3.01548042
32positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.97180637
33import into cell (GO:0098657)2.91833683
34extracellular matrix assembly (GO:0085029)2.90011849
35synaptic vesicle exocytosis (GO:0016079)2.88903803
36peripheral nervous system axon ensheathment (GO:0032292)2.88227287
37myelination in peripheral nervous system (GO:0022011)2.88227287
38positive regulation of axon extension (GO:0045773)2.87334909
39sarcoplasmic reticulum calcium ion transport (GO:0070296)2.86717823
40negative regulation of catenin import into nucleus (GO:0035414)2.85024353
41peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.81846535
42regulation of synapse maturation (GO:0090128)2.80390831
43regulation of ARF protein signal transduction (GO:0032012)2.79666276
44positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.77357702
45central nervous system neuron axonogenesis (GO:0021955)2.77189173
46cardiac myofibril assembly (GO:0055003)2.76209657
47establishment of nucleus localization (GO:0040023)2.75666272
48muscle filament sliding (GO:0030049)2.74880909
49actin-myosin filament sliding (GO:0033275)2.74880909
50cytoskeletal anchoring at plasma membrane (GO:0007016)2.73693938
51regulation of dendritic spine morphogenesis (GO:0061001)2.72941753
52protein heterotrimerization (GO:0070208)2.71524143
53regulation of axon extension involved in axon guidance (GO:0048841)2.71211845
54amino acid import (GO:0043090)2.70330664
55potassium ion homeostasis (GO:0055075)2.68388894
56cell communication by electrical coupling (GO:0010644)2.67955250
57adherens junction assembly (GO:0034333)2.66907835
58neuron projection extension (GO:1990138)2.61809058
59regulation of long-term neuronal synaptic plasticity (GO:0048169)2.61178322
60chondroitin sulfate catabolic process (GO:0030207)2.61025006
61L-amino acid import (GO:0043092)2.60965091
62regulation of neuronal synaptic plasticity (GO:0048168)2.60103957
63regulation of synaptic vesicle exocytosis (GO:2000300)2.59962227
64vascular endothelial growth factor signaling pathway (GO:0038084)2.59539178
65focal adhesion assembly (GO:0048041)2.56395542
66cell-substrate adherens junction assembly (GO:0007045)2.56395542
67positive regulation of fibroblast migration (GO:0010763)2.55248967
68cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.54143654
69potassium ion import (GO:0010107)2.54052367
70ionotropic glutamate receptor signaling pathway (GO:0035235)2.53925154
71axon extension involved in axon guidance (GO:0048846)2.52943586
72neuron projection extension involved in neuron projection guidance (GO:1902284)2.52943586
73cell communication involved in cardiac conduction (GO:0086065)2.49448459
74positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.48318240
75regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.47960546
76regulation of dendritic spine development (GO:0060998)2.45760953
77endothelial cell chemotaxis (GO:0035767)2.45613466
78gamma-aminobutyric acid transport (GO:0015812)2.44119481
79proline transport (GO:0015824)2.43679337
80regulation of axon guidance (GO:1902667)2.43487188
81sodium ion export (GO:0071436)2.43460469
82neuronal action potential propagation (GO:0019227)2.43350475
83cell migration involved in heart development (GO:0060973)2.43122327
84creatine metabolic process (GO:0006600)2.42925399
85presynaptic membrane organization (GO:0097090)2.42835647
86dendritic spine organization (GO:0097061)2.41936763
87activation of protein kinase A activity (GO:0034199)2.41382387
88camera-type eye morphogenesis (GO:0048593)2.41331853
89regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.41196444
90protein targeting to plasma membrane (GO:0072661)2.40679560
91cell-substrate junction assembly (GO:0007044)2.40486749
92neuronal ion channel clustering (GO:0045161)2.38927289
93regulation of axon extension (GO:0030516)2.38896041
94regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.38746523
95insulin-like growth factor receptor signaling pathway (GO:0048009)2.38260375
96presynaptic membrane assembly (GO:0097105)2.37625192
97positive regulation of glycogen biosynthetic process (GO:0045725)2.36240235
98glutamate receptor signaling pathway (GO:0007215)2.36189965
99regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.35416813
100semaphorin-plexin signaling pathway (GO:0071526)2.35143463
101actin-mediated cell contraction (GO:0070252)2.34076795
102astrocyte development (GO:0014002)2.32932040
103neurotransmitter secretion (GO:0007269)2.31918263
104regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.31784760
105neuromuscular junction development (GO:0007528)2.31306289
106cellular sodium ion homeostasis (GO:0006883)2.30687759
107myotube differentiation (GO:0014902)2.30541105
108membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.30387978
109* cerebellar granule cell differentiation (GO:0021707)2.30338143
110cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.30238713
111negative regulation of protein localization to cell surface (GO:2000009)2.29662666
112regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.29216513
113regulation of excitatory postsynaptic membrane potential (GO:0060079)2.28759829
114glial cell proliferation (GO:0014009)2.27881664
115extracellular fibril organization (GO:0043206)2.27089712
116synaptic transmission, glutamatergic (GO:0035249)2.26765222
117regulation of neuron migration (GO:2001222)2.26455192
118regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.26343412
119positive regulation of dendritic spine development (GO:0060999)2.26128126
120kidney mesenchyme development (GO:0072074)2.25874205
121cellular response to catecholamine stimulus (GO:0071870)2.25612919
122cellular response to monoamine stimulus (GO:0071868)2.25612919
123regulation of synaptic vesicle transport (GO:1902803)2.25491438
124myofibril assembly (GO:0030239)2.24560024
125synapse organization (GO:0050808)2.24306505
126axon ensheathment in central nervous system (GO:0032291)2.24087452
127central nervous system myelination (GO:0022010)2.24087452
128regulation of early endosome to late endosome transport (GO:2000641)2.24083744
129planar cell polarity pathway involved in neural tube closure (GO:0090179)2.23178583
130barbed-end actin filament capping (GO:0051016)2.22577981
131regulation of glucose import in response to insulin stimulus (GO:2001273)2.22463236
132negative regulation of axon extension (GO:0030517)2.22311939
133positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.21256046
134long-term memory (GO:0007616)2.21231474
135skeletal muscle fiber development (GO:0048741)2.20724422
136neuromuscular process controlling balance (GO:0050885)2.20405398
137regulation of synaptic plasticity (GO:0048167)2.19893912
138positive regulation of dendrite development (GO:1900006)2.19559730
139metanephric mesenchyme development (GO:0072075)2.19543362
140positive regulation of myotube differentiation (GO:0010831)2.19187659
141neuron projection morphogenesis (GO:0048812)2.19005229
142positive regulation of fatty acid beta-oxidation (GO:0032000)2.18841323
143regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.18211724
144myoblast fusion (GO:0007520)2.17955476
145collagen fibril organization (GO:0030199)2.17903586
146cerebral cortex cell migration (GO:0021795)2.17371812
147positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.16760246
148negative regulation of axon extension involved in axon guidance (GO:0048843)2.16631727
149regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.14686143
150regulation of cell communication by electrical coupling (GO:0010649)2.14027846
151regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.13853444
152vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.11528012
153stress fiber assembly (GO:0043149)2.11138386
154skin morphogenesis (GO:0043589)2.10655128
155striated muscle contraction (GO:0006941)2.10653587

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.03942422
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.67775447
3* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.60133551
4* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.60133551
5* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.55390101
6* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.51941356
7* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.33018029
8* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.31973045
9* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.27299218
10* EZH2_27304074_Chip-Seq_ESCs_Mouse2.27179190
11* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25564554
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.23108933
13DROSHA_22980978_ChIP-Seq_HELA_Human2.22189353
14* EED_16625203_ChIP-ChIP_MESCs_Mouse2.18167995
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.10727824
16* EZH2_27294783_Chip-Seq_ESCs_Mouse2.08633948
17* RNF2_27304074_Chip-Seq_ESCs_Mouse2.07653167
18GBX2_23144817_ChIP-Seq_PC3_Human2.07187894
19AR_21572438_ChIP-Seq_LNCaP_Human2.01355631
20SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99342769
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.94611177
22* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75049264
23WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.73622073
24RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.66775969
25CLOCK_20551151_ChIP-Seq_293T_Human1.62336338
26NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.60140872
27TP63_17297297_ChIP-ChIP_HaCaT_Human1.59600947
28EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.56084861
29ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.55571298
30RARB_27405468_Chip-Seq_BRAIN_Mouse1.54311545
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.53386729
32GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47546065
33ZNF217_24962896_ChIP-Seq_MCF-7_Human1.47493111
34* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47269954
35EP300_21415370_ChIP-Seq_HL-1_Mouse1.46813449
36* KDM2B_26808549_Chip-Seq_K562_Human1.46763316
37* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.44138678
38TBX20_22328084_ChIP-Seq_HEART_Mouse1.41156482
39TBX20_22080862_ChIP-Seq_HEART_Mouse1.41156482
40RING1B_27294783_Chip-Seq_ESCs_Mouse1.38897746
41ERG_21242973_ChIP-ChIP_JURKAT_Human1.37883418
42REST_21632747_ChIP-Seq_MESCs_Mouse1.37399303
43WT1_25993318_ChIP-Seq_PODOCYTE_Human1.36914302
44TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.36874360
45* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.36327665
46ZFP281_18757296_ChIP-ChIP_E14_Mouse1.36292362
47KDM2B_26808549_Chip-Seq_DND41_Human1.35649757
48NFIB_24661679_ChIP-Seq_LUNG_Mouse1.35075283
49RACK7_27058665_Chip-Seq_MCF-7_Human1.33690726
50TP53_20018659_ChIP-ChIP_R1E_Mouse1.30631369
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30469936
52* RING1B_27294783_Chip-Seq_NPCs_Mouse1.28450178
53CDX2_19796622_ChIP-Seq_MESCs_Mouse1.27878705
54ELK3_25401928_ChIP-Seq_HUVEC_Human1.27501181
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.24560927
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.24342518
57P300_27058665_Chip-Seq_ZR-75-30cells_Human1.23466597
58ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.23251611
59CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21646450
60* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.21448487
61SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.20496348
62AHR_22903824_ChIP-Seq_MCF-7_Human1.20264338
63ESR2_21235772_ChIP-Seq_MCF-7_Human1.20211886
64ESR1_20079471_ChIP-ChIP_T-47D_Human1.19746751
65* TET1_21490601_ChIP-Seq_MESCs_Mouse1.19352414
66* TP53_23651856_ChIP-Seq_MEFs_Mouse1.19071165
67DNAJC2_21179169_ChIP-ChIP_NT2_Human1.18208875
68THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.17634202
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.17331956
70IKZF1_21737484_ChIP-ChIP_HCT116_Human1.16890428
71UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.16576927
72KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15944614
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.15877803
74TP53_16413492_ChIP-PET_HCT116_Human1.15726454
75ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.15721373
76CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14299620
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.13432240
78NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13374827
79TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.12904863
80ESR1_21235772_ChIP-Seq_MCF-7_Human1.12591099
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12426670
82TCF7_22412390_ChIP-Seq_EML_Mouse1.12157313
83CREB1_26743006_Chip-Seq_LNCaP_Human1.11956090
84PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.10282561
85CTBP2_25329375_ChIP-Seq_LNCAP_Human1.09867234
86TP53_18474530_ChIP-ChIP_U2OS_Human1.09760286
87* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.08815199
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.08244260
89SMC1_22415368_ChIP-Seq_MEFs_Mouse1.07938194
90SOX2_21211035_ChIP-Seq_LN229_Gbm1.07278898
91AR_19668381_ChIP-Seq_PC3_Human1.06576781
92CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05125539
93ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05099806
94PIAS1_25552417_ChIP-Seq_VCAP_Human1.04830685
95DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.04636775
96VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.03520706
97SMAD4_21799915_ChIP-Seq_A2780_Human1.02488433
98SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.02464348
99* SMC4_20622854_ChIP-Seq_HELA_Human1.02326711
100* CBX2_27304074_Chip-Seq_ESCs_Mouse1.02204966
101* SMAD4_21741376_ChIP-Seq_HESCs_Human1.01422576
102ISL1_27105846_Chip-Seq_CPCs_Mouse1.00982865
103* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.00210070
104CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99933398
105NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.99573653
106KDM2B_26808549_Chip-Seq_JURKAT_Human0.98190141
107SMC3_22415368_ChIP-Seq_MEFs_Mouse0.97794065
108RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97062230
109SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96234767
110ZNF274_21170338_ChIP-Seq_K562_Hela0.95621731
111TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94985444
112* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.94848531
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.94821655
114RXR_22108803_ChIP-Seq_LS180_Human0.94645297
115PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94496177
116SMAD3_21741376_ChIP-Seq_HESCs_Human0.94430784
117BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93518625
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.93155325
119NRF2_20460467_ChIP-Seq_MEFs_Mouse0.93155325
120SMAD_19615063_ChIP-ChIP_OVARY_Human0.93037039
121* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.92850967
122CTNNB1_20460455_ChIP-Seq_HCT116_Human0.92508581
123* LXR_22292898_ChIP-Seq_THP-1_Human0.90951800
124SMAD3_21741376_ChIP-Seq_EPCs_Human0.90168168
125OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.89851443
126AR_25329375_ChIP-Seq_VCAP_Human0.89650417
127CTCF_27219007_Chip-Seq_Bcells_Human0.88662654
128* CJUN_26792858_Chip-Seq_BT549_Human0.88008728
129TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.87939220
130TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.87816444
131* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.87675047
132CTCF_27219007_Chip-Seq_ERYTHROID_Human0.87369661
133* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87361874
134SA1_27219007_Chip-Seq_ERYTHROID_Human0.83586009

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.58460862
2MP0008438_abnormal_cutaneous_collagen3.51116168
3MP0005275_abnormal_skin_tensile2.94491133
4MP0000751_myopathy2.93178553
5MP0003705_abnormal_hypodermis_morpholog2.88698771
6MP0009780_abnormal_chondrocyte_physiolo2.85187716
7MP0002837_dystrophic_cardiac_calcinosis2.49591212
8MP0003635_abnormal_synaptic_transmissio2.47768581
9MP0004270_analgesia2.46242786
10MP0005503_abnormal_tendon_morphology2.38851176
11MP0004858_abnormal_nervous_system2.16673346
12MP0002063_abnormal_learning/memory/cond1.94432127
13* MP0000778_abnormal_nervous_system1.91737613
14MP0005623_abnormal_meninges_morphology1.84593145
15MP0003879_abnormal_hair_cell1.73199905
16MP0002234_abnormal_pharynx_morphology1.72643022
17MP0004130_abnormal_muscle_cell1.65425700
18MP0003329_amyloid_beta_deposits1.63281844
19MP0003880_abnormal_central_pattern1.61596784
20MP0009745_abnormal_behavioral_response1.58584603
21MP0005670_abnormal_white_adipose1.57029418
22MP0004145_abnormal_muscle_electrophysio1.55346020
23MP0004885_abnormal_endolymph1.51400655
24MP0003690_abnormal_glial_cell1.47460415
25MP0005409_darkened_coat_color1.46607393
26MP0002064_seizures1.45828675
27MP0001958_emphysema1.42951552
28MP0000579_abnormal_nail_morphology1.42755941
29MP0005423_abnormal_somatic_nervous1.40317300
30MP0009384_cardiac_valve_regurgitation1.40265999
31MP0001299_abnormal_eye_distance/1.39063838
32MP0000749_muscle_degeneration1.38778247
33MP0002734_abnormal_mechanical_nocicepti1.37509726
34MP0003091_abnormal_cell_migration1.36186893
35MP0004087_abnormal_muscle_fiber1.34585843
36MP0002184_abnormal_innervation1.34047085
37MP0002108_abnormal_muscle_morphology1.32578038
38MP0003279_aneurysm1.32393112
39MP0002572_abnormal_emotion/affect_behav1.32176079
40MP0003566_abnormal_cell_adhesion1.31476833
41MP0001502_abnormal_circadian_rhythm1.26127163
42MP0000920_abnormal_myelination1.24149270
43* MP0008569_lethality_at_weaning1.23441326
44MP0009046_muscle_twitch1.20830461
45MP0003385_abnormal_body_wall1.20373640
46MP0004215_abnormal_myocardial_fiber1.20139597
47MP0001177_atelectasis1.19751586
48MP0004811_abnormal_neuron_physiology1.19546698
49MP0003137_abnormal_impulse_conducting1.17583619
50MP0000759_abnormal_skeletal_muscle1.16571091
51MP0005187_abnormal_penis_morphology1.16003075
52MP0000955_abnormal_spinal_cord1.14284398
53MP0003634_abnormal_glial_cell1.14278463
54MP0009250_abnormal_appendicular_skeleto1.13175119
55MP0001486_abnormal_startle_reflex1.12604671
56MP0001968_abnormal_touch/_nociception1.11856601
57MP0000537_abnormal_urethra_morphology1.10016866
58MP0005620_abnormal_muscle_contractility1.09580243
59MP0001440_abnormal_grooming_behavior1.08985570
60MP0004233_abnormal_muscle_weight1.08074960
61MP0002269_muscular_atrophy1.07746702
62* MP0002896_abnormal_bone_mineralization1.07512272
63MP0001348_abnormal_lacrimal_gland1.07094080
64MP0000733_abnormal_muscle_development1.06343147
65MP0002249_abnormal_larynx_morphology1.04352163
66MP0000747_muscle_weakness1.03916899
67MP0005330_cardiomyopathy1.02660604
68MP0004484_altered_response_of1.01789551
69MP0002060_abnormal_skin_morphology1.01517013
70MP0010368_abnormal_lymphatic_system1.01445223
71MP0005369_muscle_phenotype0.98579351
72MP0006138_congestive_heart_failure0.96964184
73MP0002909_abnormal_adrenal_gland0.96847014
74MP0003646_muscle_fatigue0.96068350
75MP0004272_abnormal_basement_membrane0.95675954
76MP0002295_abnormal_pulmonary_circulatio0.95636875
77MP0002557_abnormal_social/conspecific_i0.95348892
78MP0005257_abnormal_intraocular_pressure0.94614471
79MP0005508_abnormal_skeleton_morphology0.94390726
80MP0004134_abnormal_chest_morphology0.94219727
81MP0002735_abnormal_chemical_nociception0.94213404
82MP0004084_abnormal_cardiac_muscle0.93388035
83MP0005595_abnormal_vascular_smooth0.92926516
84MP0002106_abnormal_muscle_physiology0.92687699
85MP0004085_abnormal_heartbeat0.92611558
86MP0000013_abnormal_adipose_tissue0.92417730
87MP0002882_abnormal_neuron_morphology0.92394779
88MP0002972_abnormal_cardiac_muscle0.91948897
89MP0000534_abnormal_ureter_morphology0.91911090
90MP0002272_abnormal_nervous_system0.90884450
91MP0004036_abnormal_muscle_relaxation0.89701092
92MP0002736_abnormal_nociception_after0.89237018
93MP0000750_abnormal_muscle_regeneration0.87526193
94MP0000767_abnormal_smooth_muscle0.87158432
95MP0003755_abnormal_palate_morphology0.87044658
96* MP0002067_abnormal_sensory_capabilities0.85760445
97MP0004185_abnormal_adipocyte_glucose0.85670398
98MP0001849_ear_inflammation0.85407817
99MP0005248_abnormal_Harderian_gland0.84833373
100MP0001501_abnormal_sleep_pattern0.84682096
101MP0005076_abnormal_cell_differentiation0.83376534
102MP0002089_abnormal_postnatal_growth/wei0.82694217
103* MP0002152_abnormal_brain_morphology0.82394266
104MP0003633_abnormal_nervous_system0.82280511
105MP0000049_abnormal_middle_ear0.81907674
106MP0005451_abnormal_body_composition0.80998063
107MP0002971_abnormal_brown_adipose0.80750646
108MP0005375_adipose_tissue_phenotype0.79894574
109MP0002733_abnormal_thermal_nociception0.79867562
110MP0000762_abnormal_tongue_morphology0.79794585
111* MP0002066_abnormal_motor_capabilities/c0.79270548
112MP0005023_abnormal_wound_healing0.78526385
113MP0003115_abnormal_respiratory_system0.78362091
114MP0003045_fibrosis0.77455233
115MP0003075_altered_response_to0.77382751
116MP0005666_abnormal_adipose_tissue0.76981684
117MP0000003_abnormal_adipose_tissue0.76452835
118MP0010234_abnormal_vibrissa_follicle0.76197706
119MP0005171_absent_coat_pigmentation0.75039204
120MP0004510_myositis0.74714587
121MP0002822_catalepsy0.73777039
122MP0001542_abnormal_bone_strength0.73116639
123MP0010630_abnormal_cardiac_muscle0.72184360
124MP0009379_abnormal_foot_pigmentation0.72034963
125MP0003283_abnormal_digestive_organ0.71599846
126MP0001970_abnormal_pain_threshold0.70436906
127MP0005388_respiratory_system_phenotype0.69543273
128MP0002133_abnormal_respiratory_system0.69543273
129MP0003942_abnormal_urinary_system0.69298247

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.18586958
2Muscle fiber inclusion bodies (HP:0100299)3.89860767
3Nemaline bodies (HP:0003798)3.79461240
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.79280887
5Premature rupture of membranes (HP:0001788)3.73370809
6Broad metatarsal (HP:0001783)3.54424994
7* Shallow orbits (HP:0000586)3.46159257
8Type 1 muscle fiber predominance (HP:0003803)3.43388855
9Aortic aneurysm (HP:0004942)3.28892312
10Increased variability in muscle fiber diameter (HP:0003557)3.15030437
11* Obstructive sleep apnea (HP:0002870)3.01924747
12Vascular tortuosity (HP:0004948)2.91659639
13Increased connective tissue (HP:0009025)2.88615122
14Atrophic scars (HP:0001075)2.87766622
15Exercise-induced myalgia (HP:0003738)2.84004809
16Sudden death (HP:0001699)2.77813851
17Ankle contracture (HP:0006466)2.72529030
18Abnormality of skeletal muscle fiber size (HP:0012084)2.70623705
19Hyporeflexia of lower limbs (HP:0002600)2.63903938
20Myokymia (HP:0002411)2.62624495
21Bladder diverticulum (HP:0000015)2.61783588
22Myopathic facies (HP:0002058)2.60740517
23Megalencephaly (HP:0001355)2.59717538
24Focal motor seizures (HP:0011153)2.59402248
25Difficulty running (HP:0009046)2.55438016
26Centrally nucleated skeletal muscle fibers (HP:0003687)2.55377539
27Arterial tortuosity (HP:0005116)2.54321325
28Fragile skin (HP:0001030)2.52953276
29Mildly elevated creatine phosphokinase (HP:0008180)2.47622471
30Focal seizures (HP:0007359)2.46675965
31Genetic anticipation (HP:0003743)2.44920231
32Ulnar deviation of the wrist (HP:0003049)2.43743239
33Hyperventilation (HP:0002883)2.41634105
34Distal arthrogryposis (HP:0005684)2.40856724
35Wormian bones (HP:0002645)2.40142596
36Abnormality of the calf musculature (HP:0001430)2.37827863
37Distal lower limb muscle weakness (HP:0009053)2.37437301
38Right ventricular cardiomyopathy (HP:0011663)2.35489135
39Spinal rigidity (HP:0003306)2.35359990
40Muscle fiber splitting (HP:0003555)2.35074844
41Cerebral inclusion bodies (HP:0100314)2.33442118
42Mitral regurgitation (HP:0001653)2.28372194
43Visual hallucinations (HP:0002367)2.28309459
44Calcaneovalgus deformity (HP:0001848)2.26169292
45Lower limb amyotrophy (HP:0007210)2.26058317
46Action tremor (HP:0002345)2.25646145
47Myotonia (HP:0002486)2.21207511
48Bronchomalacia (HP:0002780)2.21144072
49Turricephaly (HP:0000262)2.18288321
50Coronal craniosynostosis (HP:0004440)2.17828381
51Neurofibrillary tangles (HP:0002185)2.15602200
52Asymmetric septal hypertrophy (HP:0001670)2.14782852
53Achilles tendon contracture (HP:0001771)2.13440736
54Aortic dissection (HP:0002647)2.13171643
55Epileptic encephalopathy (HP:0200134)2.13166976
56Buphthalmos (HP:0000557)2.12785233
57Broad face (HP:0000283)2.12127745
58Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.10277982
59Aplasia involving bones of the extremities (HP:0009825)2.09649119
60Aplasia involving bones of the upper limbs (HP:0009823)2.09649119
61Aplasia of the phalanges of the hand (HP:0009802)2.09649119
62Dysmetric saccades (HP:0000641)2.09242388
63Broad-based gait (HP:0002136)2.08478567
64Distal lower limb amyotrophy (HP:0008944)2.08431125
65Neck muscle weakness (HP:0000467)2.08142776
66Cervical subluxation (HP:0003308)2.07292323
67Deformed tarsal bones (HP:0008119)2.07291562
68Follicular hyperkeratosis (HP:0007502)2.07249706
69Poor eye contact (HP:0000817)2.05799486
70Slender build (HP:0001533)2.05732057
71Mitral valve prolapse (HP:0001634)2.05023693
72Genu recurvatum (HP:0002816)2.03459329
73Progressive cerebellar ataxia (HP:0002073)2.03141891
74Round ear (HP:0100830)2.02116960
75Peritonitis (HP:0002586)2.01601701
76Excessive salivation (HP:0003781)2.01062777
77Drooling (HP:0002307)2.01062777
78Abnormality of the Achilles tendon (HP:0005109)2.00327047
79Torticollis (HP:0000473)1.99327715
80Foot dorsiflexor weakness (HP:0009027)1.98711786
81Abnormal social behavior (HP:0012433)1.98503572
82Impaired social interactions (HP:0000735)1.98503572
83Supranuclear gaze palsy (HP:0000605)1.98336783
84EMG: myopathic abnormalities (HP:0003458)1.97957122
85Wrist flexion contracture (HP:0001239)1.96417267
86Biconcave vertebral bodies (HP:0004586)1.96065599
87Infantile muscular hypotonia (HP:0008947)1.95108930
88Dilatation of the ascending aorta (HP:0005111)1.95006217
89Deviation of the hallux (HP:0010051)1.94959360
90Aneurysm (HP:0002617)1.94767646
91Neonatal short-limb short stature (HP:0008921)1.94434810
92Vertebral compression fractures (HP:0002953)1.92578131
93Subaortic stenosis (HP:0001682)1.92381287
94Abnormality of the left ventricular outflow tract (HP:0011103)1.92381287
95Hepatoblastoma (HP:0002884)1.92198111
96Limb-girdle muscle weakness (HP:0003325)1.91234365
97Mild short stature (HP:0003502)1.91233995
98Hallux valgus (HP:0001822)1.88832150
99Bundle branch block (HP:0011710)1.88724234
100Cerebral aneurysm (HP:0004944)1.87963415
101Calf muscle hypertrophy (HP:0008981)1.87010669
102Lymphangioma (HP:0100764)1.86776695
103Muscle hypertrophy of the lower extremities (HP:0008968)1.85356742
104Abnormality of the foot musculature (HP:0001436)1.84409476
105Wide anterior fontanel (HP:0000260)1.84323484
106Insomnia (HP:0100785)1.84287594
107Flat cornea (HP:0007720)1.83801189
108Abnormality of binocular vision (HP:0011514)1.83691452
109Diplopia (HP:0000651)1.83691452
110Short 4th metacarpal (HP:0010044)1.83690629
111Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.83690629
112Hypoplasia of the iris (HP:0007676)1.83321325
113Bowel diverticulosis (HP:0005222)1.82764225
114* Hyperextensible skin (HP:0000974)1.81341083
115Limb-girdle muscle atrophy (HP:0003797)1.80349343
116Scapular winging (HP:0003691)1.80162410
117Aortic regurgitation (HP:0001659)1.79848075
118Insidious onset (HP:0003587)1.76817999
119Termporal pattern (HP:0011008)1.76817999
120Joint laxity (HP:0001388)1.76236664
121Abnormality of the lower motor neuron (HP:0002366)1.76062704
122Abnormality of the 4th metacarpal (HP:0010012)1.75809630
123Exercise-induced muscle cramps (HP:0003710)1.75174872
124Ankle clonus (HP:0011448)1.75168222
125Difficulty climbing stairs (HP:0003551)1.74961621
126Ventricular tachycardia (HP:0004756)1.74613114
127Muscle stiffness (HP:0003552)1.73862744
128Ulnar bowing (HP:0003031)1.73003398
129Hyperacusis (HP:0010780)1.72837289
130Soft skin (HP:0000977)1.72361135
131Generalized amyotrophy (HP:0003700)1.71876807
132Atrial fibrillation (HP:0005110)1.71491021
133Renovascular hypertension (HP:0100817)1.71142948
134Abnormal atrioventricular conduction (HP:0005150)1.70963045
135Primary atrial arrhythmia (HP:0001692)1.70627579
136Macroorchidism (HP:0000053)1.70503603
137Abnormality of dentin (HP:0010299)1.70349632
138Hip contracture (HP:0003273)1.70107958
139Hypoventilation (HP:0002791)1.69782743
140Stridor (HP:0010307)1.69010627
141Enlarged penis (HP:0000040)1.68663548
142Bulbar palsy (HP:0001283)1.68341443

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.59299866
2TRIB33.26851846
3PHKG22.60708627
4PHKG12.60708627
5EPHA42.24103499
6SIK12.16913710
7DAPK22.03018273
8LATS22.02510372
9TTN1.99822738
10AKT31.98500999
11PAK61.94422638
12EPHB21.86855093
13DDR21.85670999
14NTRK31.84058229
15MAP3K41.84008249
16RIPK11.79126724
17DMPK1.77686592
18MAP3K91.68860674
19NTRK21.65580792
20PKN21.65402640
21MINK11.54947983
22CAMKK11.52442369
23PDGFRA1.45636623
24CASK1.41258931
25PRKD31.40634155
26PRKD21.39572032
27LMTK21.32481639
28FGFR21.32189017
29MAP2K41.30354480
30TNK21.28956813
31SIK21.28421458
32ERN11.25327346
33TESK11.24503779
34MAP2K71.23362074
35PAK31.22444061
36CDK121.19961992
37LATS11.19313662
38FER1.17718433
39SMG11.16056657
40TAOK11.13530540
41PRPF4B1.13467655
42NTRK11.08871922
43MAPK131.08748439
44CDK51.08352564
45MYLK1.07182015
46DYRK21.07058838
47PIK3CA1.06215782
48MARK21.04341564
49RET1.03248445
50CAMK1G1.02646447
51WNK11.01591294
52MTOR0.99951527
53MOS0.99294510
54KSR10.98718301
55ILK0.94355373
56PKN10.94311680
57PLK20.94004702
58TYRO30.92580929
59CAMK2G0.91128628
60ARAF0.90714686
61MAP3K70.90304405
62MAPK120.90103661
63NEK90.89098618
64EEF2K0.88908075
65PTK2B0.87317678
66STK110.86082053
67EPHA30.84276374
68MAPK70.84267992
69ERBB30.81909367
70CAMK2B0.81088149
71PRKCH0.80270893
72ROCK10.80034822
73PTK60.79172226
74ROCK20.78995672
75KSR20.78456750
76STK380.77907879
77MAP3K130.76673025
78BMX0.74628219
79RPS6KA20.72983395
80TRPM70.71485174
81MAPKAPK30.70129827
82ICK0.69982147
83GRK50.69899733
84CDK150.68056266
85PRKCG0.67847741
86PRKD10.66880854
87MAPK100.65708453
88HIPK20.65230372
89CDK180.65023467
90CAMK2A0.64831257
91SGK4940.64450770
92SGK2230.64450770
93CAMK10.64196989
94UHMK10.64174385
95SGK30.63750687
96CDK140.62579750
97PRKCZ0.60769467
98PAK20.60392453
99MAPK150.60131478
100EPHB10.60066091
101MAP3K20.59883729
102CAMK40.59878882
103MAP3K60.59131430
104PTK20.58077279
105CDK11A0.56650921
106FGFR10.55594881
107OBSCN0.54979399
108CSNK1G20.54474841
109PDGFRB0.54285059
110FGFR40.53385660
111PIK3CG0.52914478
112CAMK1D0.52686238
113CDK190.52398170
114CAMKK20.52281547
115PRKCE0.51980512
116DAPK10.51629727
117MAP2K10.50997451
118DAPK30.49713311
119MAPK40.48303951
120SGK20.47855095
121PRKAA10.45894613
122ERBB20.45536006
123CAMK2D0.43979699
124DYRK1A0.43962461
125FYN0.43817524
126SGK10.42890852
127CDC42BPA0.42711380
128PDPK10.41412612
129LIMK10.41161824
130MAP3K10.40934648
131NEK60.39788487
132MAP2K30.39491749
133PRKAA20.39043529
134DYRK1B0.38328693
135RPS6KA30.36985407

Predicted pathways (KEGG)

RankGene SetZ-score
1Circadian entrainment_Homo sapiens_hsa047131.84562065
2Axon guidance_Homo sapiens_hsa043601.77399589
3Nitrogen metabolism_Homo sapiens_hsa009101.72362625
4Glutamatergic synapse_Homo sapiens_hsa047241.69378439
5Nicotine addiction_Homo sapiens_hsa050331.66464336
6Dilated cardiomyopathy_Homo sapiens_hsa054141.64725704
7Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.59851576
8Long-term potentiation_Homo sapiens_hsa047201.59418941
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.55548960
10Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.53626821
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.53169815
12GABAergic synapse_Homo sapiens_hsa047271.52881288
13Gastric acid secretion_Homo sapiens_hsa049711.50622322
14Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48831362
15Salivary secretion_Homo sapiens_hsa049701.48062732
16Synaptic vesicle cycle_Homo sapiens_hsa047211.46689976
17Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.43863578
18Olfactory transduction_Homo sapiens_hsa047401.39390715
19Oxytocin signaling pathway_Homo sapiens_hsa049211.38128316
20Cholinergic synapse_Homo sapiens_hsa047251.37852724
21Dopaminergic synapse_Homo sapiens_hsa047281.37229661
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.34813523
23Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.33344599
24Glioma_Homo sapiens_hsa052141.33228943
25Amphetamine addiction_Homo sapiens_hsa050311.32673462
26Renin secretion_Homo sapiens_hsa049241.32054820
27Prion diseases_Homo sapiens_hsa050201.31870211
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31372384
29Morphine addiction_Homo sapiens_hsa050321.27952224
30GnRH signaling pathway_Homo sapiens_hsa049121.26484120
31Gap junction_Homo sapiens_hsa045401.22796345
32Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.22443040
33Estrogen signaling pathway_Homo sapiens_hsa049151.20831022
34Long-term depression_Homo sapiens_hsa047301.20432550
35Insulin secretion_Homo sapiens_hsa049111.19687872
36Melanogenesis_Homo sapiens_hsa049161.17539500
37Focal adhesion_Homo sapiens_hsa045101.16994684
38ECM-receptor interaction_Homo sapiens_hsa045121.16930961
39Type II diabetes mellitus_Homo sapiens_hsa049301.13239494
40ErbB signaling pathway_Homo sapiens_hsa040121.10724785
41Notch signaling pathway_Homo sapiens_hsa043301.06829325
42Circadian rhythm_Homo sapiens_hsa047101.05727945
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.05548446
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.03825911
45Calcium signaling pathway_Homo sapiens_hsa040201.03804422
46cAMP signaling pathway_Homo sapiens_hsa040241.01839164
47Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.00807868
48Endometrial cancer_Homo sapiens_hsa052131.00165867
49Basal cell carcinoma_Homo sapiens_hsa052171.00138853
50Cocaine addiction_Homo sapiens_hsa050300.95941939
51Amoebiasis_Homo sapiens_hsa051460.91678043
52Taste transduction_Homo sapiens_hsa047420.90259971
53Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88212618
54Renal cell carcinoma_Homo sapiens_hsa052110.87551602
55Proteoglycans in cancer_Homo sapiens_hsa052050.87501154
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85068203
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.84355440
58Wnt signaling pathway_Homo sapiens_hsa043100.83975004
59Arginine and proline metabolism_Homo sapiens_hsa003300.83803764
60Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83537285
61Hedgehog signaling pathway_Homo sapiens_hsa043400.83069201
62Serotonergic synapse_Homo sapiens_hsa047260.82535088
63Histidine metabolism_Homo sapiens_hsa003400.81708551
64Chronic myeloid leukemia_Homo sapiens_hsa052200.80774452
65Vascular smooth muscle contraction_Homo sapiens_hsa042700.80711308
66Insulin signaling pathway_Homo sapiens_hsa049100.80355332
67Hippo signaling pathway_Homo sapiens_hsa043900.80048471
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79596430
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79440783
70Butanoate metabolism_Homo sapiens_hsa006500.79402660
71Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.78475770
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77827454
73VEGF signaling pathway_Homo sapiens_hsa043700.77307506
74Longevity regulating pathway - mammal_Homo sapiens_hsa042110.76497004
75Phospholipase D signaling pathway_Homo sapiens_hsa040720.76075349
76Neurotrophin signaling pathway_Homo sapiens_hsa047220.75971146
77Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.75518654
78Insulin resistance_Homo sapiens_hsa049310.74797282
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74793634
80Dorso-ventral axis formation_Homo sapiens_hsa043200.74572270
81Rap1 signaling pathway_Homo sapiens_hsa040150.73406912
82Bile secretion_Homo sapiens_hsa049760.73208350
83AMPK signaling pathway_Homo sapiens_hsa041520.71902375
84Cardiac muscle contraction_Homo sapiens_hsa042600.71572819
85Pancreatic secretion_Homo sapiens_hsa049720.71421868
86Colorectal cancer_Homo sapiens_hsa052100.71043764
87Tight junction_Homo sapiens_hsa045300.70935382
88Glucagon signaling pathway_Homo sapiens_hsa049220.70869317
89Protein digestion and absorption_Homo sapiens_hsa049740.67379411
90MAPK signaling pathway_Homo sapiens_hsa040100.67018918
91Choline metabolism in cancer_Homo sapiens_hsa052310.65895113
92Prostate cancer_Homo sapiens_hsa052150.65396254
93Ras signaling pathway_Homo sapiens_hsa040140.65245946
942-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.65116053
95Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.64853775
96mTOR signaling pathway_Homo sapiens_hsa041500.64812730
97Melanoma_Homo sapiens_hsa052180.63789186
98Fatty acid biosynthesis_Homo sapiens_hsa000610.63547099
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62774347
100Adherens junction_Homo sapiens_hsa045200.61736952
101Viral myocarditis_Homo sapiens_hsa054160.60649537
102Endocytosis_Homo sapiens_hsa041440.60520982
103Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60020085
104Fatty acid metabolism_Homo sapiens_hsa012120.59679974
105Inositol phosphate metabolism_Homo sapiens_hsa005620.58979482
106Lysine degradation_Homo sapiens_hsa003100.58467303
107Bladder cancer_Homo sapiens_hsa052190.57658505
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57568225
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.57000927
110MicroRNAs in cancer_Homo sapiens_hsa052060.56798766
111Non-small cell lung cancer_Homo sapiens_hsa052230.55350395
112Central carbon metabolism in cancer_Homo sapiens_hsa052300.55162610
113Arginine biosynthesis_Homo sapiens_hsa002200.55067003
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.55043158
115Phenylalanine metabolism_Homo sapiens_hsa003600.54771752
116Vitamin B6 metabolism_Homo sapiens_hsa007500.54715601
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.53949859
118Thyroid hormone synthesis_Homo sapiens_hsa049180.52339557

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