NFKB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)6.11875483
2positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.03694288
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.85350614
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.85350614
5* regulation of interleukin-12 biosynthetic process (GO:0045075)4.80764506
6antigen processing and presentation of endogenous antigen (GO:0019883)4.72694944
7regulation of gamma-delta T cell differentiation (GO:0045586)4.67403712
8NIK/NF-kappaB signaling (GO:0038061)4.60203073
9positive thymic T cell selection (GO:0045059)4.58800333
10regulation of gamma-delta T cell activation (GO:0046643)4.57947977
11* regulation of vitamin D biosynthetic process (GO:0060556)4.41372909
12myeloid dendritic cell differentiation (GO:0043011)4.21325113
13negative thymic T cell selection (GO:0045060)4.20662763
14regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.16779938
15negative T cell selection (GO:0043383)4.09667147
16regulation of T-helper 1 cell differentiation (GO:0045625)4.06798888
17myeloid dendritic cell activation (GO:0001773)3.97118936
18CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.90630758
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.88581403
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.87491779
21negative regulation of cell killing (GO:0031342)3.87491779
22positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.86771002
23positive regulation of isotype switching (GO:0045830)3.86514782
24response to muramyl dipeptide (GO:0032495)3.86191524
25leukocyte aggregation (GO:0070486)3.84688561
26defense response to protozoan (GO:0042832)3.82491232
27positive regulation of chemokine biosynthetic process (GO:0045080)3.79148340
28macrophage activation involved in immune response (GO:0002281)3.73866308
29regulation of fever generation (GO:0031620)3.73094699
30positive regulation of natural killer cell differentiation (GO:0032825)3.72662774
31response to protozoan (GO:0001562)3.72241903
32positive regulation of interleukin-2 production (GO:0032743)3.71941730
33regulation of interleukin-2 biosynthetic process (GO:0045076)3.71206990
34positive regulation by symbiont of host defense response (GO:0052509)3.69641065
35modulation by symbiont of host defense response (GO:0052031)3.69641065
36modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.69641065
37modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.69641065
38positive regulation by organism of defense response of other organism involved in symbiotic interact3.69641065
39modulation by symbiont of host immune response (GO:0052553)3.69641065
40regulation of alpha-beta T cell proliferation (GO:0046640)3.66134112
41regulation of B cell receptor signaling pathway (GO:0050855)3.61717591
42regulation of podosome assembly (GO:0071801)3.61717373
43tolerance induction (GO:0002507)3.61366725
44positive regulation of B cell differentiation (GO:0045579)3.59309817
45JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.59095197
46positive T cell selection (GO:0043368)3.57037317
47positive regulation of humoral immune response (GO:0002922)3.56759364
48regulation of chemokine biosynthetic process (GO:0045073)3.55739906
49positive regulation of immunoglobulin mediated immune response (GO:0002891)3.53548218
50positive regulation of B cell mediated immunity (GO:0002714)3.53548218
51positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.52155744
52regulation of dendritic cell antigen processing and presentation (GO:0002604)3.51000961
53positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.48796975
54regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.48023967
55thymic T cell selection (GO:0045061)3.47210674
56T-helper 1 type immune response (GO:0042088)3.46311636
57* regulation of vitamin metabolic process (GO:0030656)3.44000025
58regulation of immunoglobulin secretion (GO:0051023)3.43260094
59regulation of isotype switching to IgG isotypes (GO:0048302)3.43151485
60response to interleukin-15 (GO:0070672)3.38036992
61response to type I interferon (GO:0034340)3.36538719
62interferon-gamma-mediated signaling pathway (GO:0060333)3.33827675
63regulation of interferon-beta biosynthetic process (GO:0045357)3.33448453
64negative regulation of cytokine production involved in immune response (GO:0002719)3.32553702
65cellular response to type I interferon (GO:0071357)3.31137203
66type I interferon signaling pathway (GO:0060337)3.31137203
67positive regulation of type 2 immune response (GO:0002830)3.29895317
68tyrosine phosphorylation of STAT protein (GO:0007260)3.29538351
69positive regulation of NF-kappaB import into nucleus (GO:0042346)3.28929579
70positive regulation of alpha-beta T cell proliferation (GO:0046641)3.26793128
71positive regulation of T-helper cell differentiation (GO:0045624)3.26466195
72positive regulation of DNA recombination (GO:0045911)3.26073230
73regulation of cytokine secretion involved in immune response (GO:0002739)3.25557805
74regulation of B cell differentiation (GO:0045577)3.22690252
75regulation of regulatory T cell differentiation (GO:0045589)3.22539299
76T cell migration (GO:0072678)3.22038957
77T cell selection (GO:0045058)3.20127211
78regulation of interferon-alpha production (GO:0032647)3.17390100
79positive regulation of interleukin-12 production (GO:0032735)3.16172876
80positive regulation of interferon-alpha production (GO:0032727)3.14773537
81positive regulation of interleukin-17 production (GO:0032740)3.13436489
82interferon-gamma production (GO:0032609)3.12328712
83response to peptidoglycan (GO:0032494)3.11757564
84positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.11464823
85positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.06996632
86positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.06891217
87germinal center formation (GO:0002467)3.03558767
88dendritic cell differentiation (GO:0097028)3.02419541
89positive regulation of cytokine biosynthetic process (GO:0042108)3.01388761
90immunoglobulin mediated immune response (GO:0016064)3.01225276
91regulation of T cell tolerance induction (GO:0002664)3.01201061
92regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.98733011
93mature B cell differentiation (GO:0002335)2.97591646
94T cell lineage commitment (GO:0002360)2.96555059
95* regulation of interleukin-12 production (GO:0032655)2.93942477
96negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.93780032
97regulation of chronic inflammatory response (GO:0002676)2.92866921
98positive regulation of T cell cytokine production (GO:0002726)2.92753738
99regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.91227212
100positive regulation of immunoglobulin production (GO:0002639)2.89893883
101detection of other organism (GO:0098543)2.89201403
102regulation of T-helper 2 cell differentiation (GO:0045628)2.89144686
103regulation of interleukin-2 production (GO:0032663)2.87972217
104regulation of immunoglobulin mediated immune response (GO:0002889)2.87909061
105regulation of B cell mediated immunity (GO:0002712)2.87627282
106natural killer cell differentiation (GO:0001779)2.87344040
107positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.87321299
108regulation of T-helper cell differentiation (GO:0045622)2.86654035
109regulation of isotype switching (GO:0045191)2.86186146
110* negative regulation of interleukin-12 production (GO:0032695)2.83160252
111cellular response to interleukin-15 (GO:0071350)2.83052945
112positive regulation of defense response to virus by host (GO:0002230)2.82448859
113neutrophil activation involved in immune response (GO:0002283)2.82438250
114regulation of antigen processing and presentation (GO:0002577)2.81222919
115positive regulation of interleukin-10 production (GO:0032733)2.80947611
116regulation of type 2 immune response (GO:0002828)2.80880641
117T cell homeostasis (GO:0043029)2.80021897
118positive regulation of interferon-beta production (GO:0032728)2.79512778
119regulation of tolerance induction (GO:0002643)2.78106060
120cellular response to interferon-gamma (GO:0071346)2.77627093
121natural killer cell activation (GO:0030101)2.77110450
122T cell proliferation (GO:0042098)2.75811351
123regulation of NF-kappaB import into nucleus (GO:0042345)2.75779274
124T-helper cell differentiation (GO:0042093)2.74977318
125CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.74977318
126regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.73846027
127regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.73412950
128positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.73068153
129B cell mediated immunity (GO:0019724)2.72962515
130regulation of heat generation (GO:0031650)2.72625216
131regulation of membrane protein ectodomain proteolysis (GO:0051043)2.72472716
132positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.72341519
133positive regulation of heat generation (GO:0031652)2.71879754
134modulation by symbiont of host cellular process (GO:0044068)2.71810949
135positive regulation of acute inflammatory response (GO:0002675)2.71737634
136regulation of type I interferon-mediated signaling pathway (GO:0060338)2.70475666
137leukocyte cell-cell adhesion (GO:0007159)2.70063643
138positive regulation of B cell activation (GO:0050871)2.69268224
139positive regulation of lymphocyte mediated immunity (GO:0002708)2.68953339
140lipopolysaccharide-mediated signaling pathway (GO:0031663)2.68517705
141growth hormone receptor signaling pathway (GO:0060396)2.67143889
142negative regulation of T cell mediated immunity (GO:0002710)2.66252887

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.77041873
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.93443846
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.91915267
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.80286349
5EGR1_19374776_ChIP-ChIP_THP-1_Human3.74206975
6* IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.61968197
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.60269641
8* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.38967690
9E2F7_22180533_ChIP-Seq_HELA_Human3.37410178
10IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.33530854
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.28424584
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.11225075
13MYC_22102868_ChIP-Seq_BL_Human3.06469553
14STAT4_19710469_ChIP-ChIP_TH1__Mouse2.99811151
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.91944225
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.89832252
17* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.77336641
18* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.71495630
19* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.68569587
20* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.59323577
21MYB_26560356_Chip-Seq_TH2_Human2.55960845
22MAF_26560356_Chip-Seq_TH1_Human2.47377812
23* RUNX_20019798_ChIP-Seq_JUKART_Human2.47149501
24FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.44080700
25NOTCH1_21737748_ChIP-Seq_TLL_Human2.43126253
26VDR_21846776_ChIP-Seq_THP-1_Human2.33595352
27MYB_26560356_Chip-Seq_TH1_Human2.22651169
28SCL_19346495_ChIP-Seq_HPC-7_Human2.19707290
29ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.14080696
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.07570664
31VDR_24763502_ChIP-Seq_THP-1_Human2.04524850
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.99558459
33* SPI1_23547873_ChIP-Seq_NB4_Human1.93511181
34UTX_26944678_Chip-Seq_JUKART_Human1.93260852
35* TCF7_22412390_ChIP-Seq_EML_Mouse1.93129072
36RUNX1_22412390_ChIP-Seq_EML_Mouse1.84219202
37NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.80567934
38* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.79596166
39RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76789402
40KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.71709091
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.59793734
42GATA3_27048872_Chip-Seq_THYMUS_Human1.59483355
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.57873025
44MAF_26560356_Chip-Seq_TH2_Human1.57774653
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.57020850
46* SPI1_23127762_ChIP-Seq_K562_Human1.53758802
47PU_27001747_Chip-Seq_BMDM_Mouse1.53505573
48TP63_17297297_ChIP-ChIP_HaCaT_Human1.44777660
49KDM2B_26808549_Chip-Seq_DND41_Human1.43681285
50KDM2B_26808549_Chip-Seq_SUP-B15_Human1.38789762
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.35001150
52PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34559241
53VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.30652939
54TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.30537728
55GATA2_22383799_ChIP-Seq_G1ME_Mouse1.29248266
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26829088
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25763718
58SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24705574
59CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.23363711
60STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.21815952
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.21776731
62GATA1_22025678_ChIP-Seq_K562_Human1.21520627
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.19028389
64* GATA3_26560356_Chip-Seq_TH2_Human1.10663679
65VDR_24787735_ChIP-Seq_THP-1_Human1.10191399
66CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08409899
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.01205192
68* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00499799
69NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.00124646
70GATA1_19941826_ChIP-Seq_K562_Human0.99724881
71TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.99283504
72GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.96381732
73KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96072680
74NCOR1_26117541_ChIP-Seq_K562_Human0.92892164
75PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91954325
76LXR_22292898_ChIP-Seq_THP-1_Human0.91464485
77EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.91263291
78SMAD_19615063_ChIP-ChIP_OVARY_Human0.91226895
79* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91193959
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.89059625
81ESR2_21235772_ChIP-Seq_MCF-7_Human0.88651258
82PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88086575
83PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.87337938
84ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85651440
85GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.85407938
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83729679
87HIF1A_21447827_ChIP-Seq_MCF-7_Human0.83394351
88* KDM2B_26808549_Chip-Seq_JURKAT_Human0.82241745
89GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81308527
90RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.80701325
91FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.79801985
92SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.79682177
93TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79645832
94* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.79377930
95* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.79377930
96CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79377524
97FOXM1_23109430_ChIP-Seq_U2OS_Human0.79291701
98THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.78955594
99TFEB_21752829_ChIP-Seq_HELA_Human0.78761250
100* GATA1_19941827_ChIP-Seq_MEL_Mouse0.78558475
101CIITA_25753668_ChIP-Seq_RAJI_Human0.78071965
102PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77696038
103* GATA2_21666600_ChIP-Seq_HMVEC_Human0.77281544
104SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76348094
105RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.75879233
106ELF1_17652178_ChIP-ChIP_JURKAT_Human0.75408365
107VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.74922963
108HOXB4_20404135_ChIP-ChIP_EML_Mouse0.74586993
109* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.74525608
110JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74141629
111GATA2_19941826_ChIP-Seq_K562_Human0.74029439
112LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.73712938
113TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.72210247

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.99567894
2MP0003436_decreased_susceptibility_to3.63409213
3MP0000685_abnormal_immune_system3.46035535
4MP0003300_gastrointestinal_ulcer3.25232387
5MP0005671_abnormal_response_to3.21409929
6* MP0005387_immune_system_phenotype3.09868727
7* MP0001790_abnormal_immune_system3.09868727
8MP0003763_abnormal_thymus_physiology3.07509260
9* MP0001800_abnormal_humoral_immune2.97597686
10* MP0005000_abnormal_immune_tolerance2.93754638
11* MP0009785_altered_susceptibility_to2.88287844
12MP0004510_myositis2.69287525
13* MP0002452_abnormal_antigen_presenting2.64540363
14* MP0002723_abnormal_immune_serum2.64240179
15* MP0005025_abnormal_response_to2.60606556
16MP0003724_increased_susceptibility_to2.60185618
17MP0002148_abnormal_hypersensitivity_rea2.57538022
18MP0001853_heart_inflammation2.46705984
19MP0002166_altered_tumor_susceptibility2.41936546
20* MP0002420_abnormal_adaptive_immunity2.40974687
21* MP0001819_abnormal_immune_cell2.40613418
22* MP0003303_peritoneal_inflammation2.35118629
23* MP0002419_abnormal_innate_immunity2.32991242
24* MP0002405_respiratory_system_inflammati2.29794806
25* MP0002398_abnormal_bone_marrow2.22762545
26MP0002396_abnormal_hematopoietic_system2.22478084
27MP0002006_tumorigenesis2.20602244
28MP0006082_CNS_inflammation2.07656062
29MP0005451_abnormal_body_composition2.05292289
30* MP0010155_abnormal_intestine_physiology2.03488108
31* MP0000716_abnormal_immune_system2.01733131
32MP0001873_stomach_inflammation1.99290613
33MP0009333_abnormal_splenocyte_physiolog1.99130259
34MP0004947_skin_inflammation1.94625389
35MP0005464_abnormal_platelet_physiology1.81407271
36MP0004808_abnormal_hematopoietic_stem1.81293539
37* MP0000689_abnormal_spleen_morphology1.77936590
38* MP0001845_abnormal_inflammatory_respons1.76663976
39MP0009840_abnormal_foam_cell1.73848196
40MP0001533_abnormal_skeleton_physiology1.73776046
41* MP0002722_abnormal_immune_system1.72850503
42* MP0002429_abnormal_blood_cell1.67215572
43MP0008004_abnormal_stomach_pH1.61332275
44* MP0000703_abnormal_thymus_morphology1.57116934
45MP0001545_abnormal_hematopoietic_system1.57115614
46MP0005397_hematopoietic_system_phenotyp1.57115614
47MP0000465_gastrointestinal_hemorrhage1.55855510
48* MP0003866_abnormal_defecation1.53655839
49MP0002933_joint_inflammation1.50104596
50MP0009278_abnormal_bone_marrow1.48342552
51MP0002138_abnormal_hepatobiliary_system1.48283973
52MP0002139_abnormal_hepatobiliary_system1.40435065
53MP0010352_gastrointestinal_tract_polyps1.38970574
54MP0005076_abnormal_cell_differentiation1.33779001
55MP0003448_altered_tumor_morphology1.33568556
56MP0002332_abnormal_exercise_endurance1.31285716
57MP0005310_abnormal_salivary_gland1.29014965
58MP0008057_abnormal_DNA_replication1.28016288
59MP0000490_abnormal_crypts_of1.26780215
60MP0003656_abnormal_erythrocyte_physiolo1.26343856
61MP0000858_altered_metastatic_potential1.23324790
62* MP0008469_abnormal_protein_level1.23156356
63MP0002998_abnormal_bone_remodeling1.19164828
64MP0009764_decreased_sensitivity_to1.17444997
65MP0002877_abnormal_melanocyte_morpholog1.03016450
66MP0005164_abnormal_response_to0.99960724
67MP0006054_spinal_hemorrhage0.99913344
68MP0002254_reproductive_system_inflammat0.99166864
69MP0010307_abnormal_tumor_latency0.97876086
70MP0001851_eye_inflammation0.97552039
71MP0000343_altered_response_to0.92876505
72MP0003195_calcinosis0.92039665
73MP0003566_abnormal_cell_adhesion0.90706840
74MP0003045_fibrosis0.88843725
75MP0008260_abnormal_autophagy0.87692257
76MP0005390_skeleton_phenotype0.87309024
77MP0002019_abnormal_tumor_incidence0.87079129
78MP0003690_abnormal_glial_cell0.86874768
79MP0003828_pulmonary_edema0.86131903
80MP0003091_abnormal_cell_migration0.85037989
81MP0000604_amyloidosis0.84746033
82MP0009763_increased_sensitivity_to0.84421167
83MP0003453_abnormal_keratinocyte_physiol0.84108530
84MP0005058_abnormal_lysosome_morphology0.83894739
85MP0005023_abnormal_wound_healing0.83370886
86MP0000371_diluted_coat_color0.76880853
87MP0003172_abnormal_lysosome_physiology0.75306171
88MP0005165_increased_susceptibility_to0.75247535
89* MP0003795_abnormal_bone_structure0.74540478
90MP0003075_altered_response_to0.74508289
91MP0003806_abnormal_nucleotide_metabolis0.73153650
92MP0001881_abnormal_mammary_gland0.71573621
93MP0000249_abnormal_blood_vessel0.70013285
94MP0008961_abnormal_basal_metabolism0.69473520
95MP0005166_decreased_susceptibility_to0.67080082
96MP0003183_abnormal_peptide_metabolism0.66347829
97MP0000733_abnormal_muscle_development0.61249744
98MP0000767_abnormal_smooth_muscle0.61101865
99MP0003221_abnormal_cardiomyocyte_apopto0.60806342
100MP0004883_abnormal_blood_vessel0.60645686
101MP0005174_abnormal_tail_pigmentation0.60298237
102MP0008874_decreased_physiological_sensi0.58722913
103MP0001348_abnormal_lacrimal_gland0.58500270
104MP0002136_abnormal_kidney_physiology0.54776799
105MP0003191_abnormal_cellular_cholesterol0.54527571
106MP0003943_abnormal_hepatobiliary_system0.54135534
107MP0008007_abnormal_cellular_replicative0.53648413
108MP0005535_abnormal_body_temperature0.53221057
109MP0005167_abnormal_blood-brain_barrier0.52769903
110* MP0000609_abnormal_liver_physiology0.52652830
111MP0000627_abnormal_mammary_gland0.52476799
112* MP0001663_abnormal_digestive_system0.52238993
113MP0000569_abnormal_digit_pigmentation0.52194193
114MP0001243_abnormal_dermal_layer0.52098607
115MP0004782_abnormal_surfactant_physiolog0.50652897
116MP0001191_abnormal_skin_condition0.49878598
117* MP0001216_abnormal_epidermal_layer0.49745180
118MP0009765_abnormal_xenobiotic_induced0.49394644

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.82478970
2Elevated erythrocyte sedimentation rate (HP:0003565)5.02572954
3Stomatitis (HP:0010280)4.90467387
4Recurrent fungal infections (HP:0002841)4.48152762
5Myositis (HP:0100614)4.38511070
6Abnormality of glycolipid metabolism (HP:0010969)4.25499510
7Abnormality of liposaccharide metabolism (HP:0010968)4.25499510
8Abnormality of glycosphingolipid metabolism (HP:0004343)4.25499510
9Recurrent viral infections (HP:0004429)4.17245735
10Recurrent abscess formation (HP:0002722)4.14827944
11Gastrointestinal infarctions (HP:0005244)4.13082206
12Mediastinal lymphadenopathy (HP:0100721)4.06881426
13Retrobulbar optic neuritis (HP:0100654)4.02826759
14Optic neuritis (HP:0100653)4.02826759
15Panhypogammaglobulinemia (HP:0003139)3.99999100
16Orchitis (HP:0100796)3.93521377
17Recurrent bacterial skin infections (HP:0005406)3.81402407
18T lymphocytopenia (HP:0005403)3.70722639
19Abnormality of T cell number (HP:0011839)3.68371711
20Thrombocytosis (HP:0001894)3.68354478
21Arterial thrombosis (HP:0004420)3.66814012
22Abnormal delayed hypersensitivity skin test (HP:0002963)3.63563642
23Vasculitis (HP:0002633)3.59490782
24Increased density of long bones (HP:0006392)3.55829051
25Chronic mucocutaneous candidiasis (HP:0002728)3.53146568
26Recurrent cutaneous fungal infections (HP:0011370)3.53146568
27Pulmonary infiltrates (HP:0002113)3.44357841
28Abnormality of T cells (HP:0002843)3.42757111
29Chronic otitis media (HP:0000389)3.29552989
30Abnormality of T cell physiology (HP:0011840)3.13852267
31Recurrent bronchitis (HP:0002837)3.12963357
32Recurrent skin infections (HP:0001581)3.08914368
33Chest pain (HP:0100749)3.08799478
34Severe combined immunodeficiency (HP:0004430)3.04494213
35Loss of speech (HP:0002371)3.02831047
36Autoimmune thrombocytopenia (HP:0001973)3.01566597
37Meningitis (HP:0001287)2.99557772
38Autoimmune hemolytic anemia (HP:0001890)2.97083032
39Vacuolated lymphocytes (HP:0001922)2.92505277
40Inflammation of the large intestine (HP:0002037)2.90390712
41Dysostosis multiplex (HP:0000943)2.88535344
42Myocardial infarction (HP:0001658)2.86471703
43Fatigue (HP:0012378)2.86394311
44IgA deficiency (HP:0002720)2.83963963
45IgM deficiency (HP:0002850)2.83565258
46Systemic lupus erythematosus (HP:0002725)2.83515939
47Gastrointestinal inflammation (HP:0004386)2.81600718
48Hemoptysis (HP:0002105)2.76495378
49Chronic obstructive pulmonary disease (HP:0006510)2.76091046
50Obstructive lung disease (HP:0006536)2.76091046
51Colitis (HP:0002583)2.75902385
52Recurrent gram-negative bacterial infections (HP:0005420)2.74417248
53Combined immunodeficiency (HP:0005387)2.73507535
54Peritonitis (HP:0002586)2.71642893
55Increased cerebral lipofuscin (HP:0011813)2.71534567
56Nasal polyposis (HP:0100582)2.70737427
57Agammaglobulinemia (HP:0004432)2.70106803
58Abnormality of macrophages (HP:0004311)2.69514090
59Cellulitis (HP:0100658)2.69046372
60Leukocytosis (HP:0001974)2.68813942
61Gastrointestinal stroma tumor (HP:0100723)2.68449788
62Persistence of primary teeth (HP:0006335)2.66805012
63Pustule (HP:0200039)2.65890400
64Increased IgM level (HP:0003496)2.64674234
65Abnormality of B cell number (HP:0010975)2.62986588
66B lymphocytopenia (HP:0010976)2.62986588
67Gingivitis (HP:0000230)2.62177844
68Keratoconjunctivitis sicca (HP:0001097)2.62172858
69Interstitial pulmonary disease (HP:0006530)2.61837041
70Periodontitis (HP:0000704)2.60886928
71Disinhibition (HP:0000734)2.59176899
72Amaurosis fugax (HP:0100576)2.59040638
73Gingival bleeding (HP:0000225)2.56729803
74Chronic diarrhea (HP:0002028)2.56038769
75Urticaria (HP:0001025)2.50520130
76Spontaneous hematomas (HP:0007420)2.49876195
77Polyneuropathy (HP:0001271)2.48706857
78Abnormality of the nasal mucosa (HP:0000433)2.45737272
79Lymphopenia (HP:0001888)2.45564689
80Abnormality of cells of the lymphoid lineage (HP:0012140)2.44614654
81Keratoconjunctivitis (HP:0001096)2.42737316
82Anorexia (HP:0002039)2.42700655
83IgG deficiency (HP:0004315)2.39453112
84Acute myeloid leukemia (HP:0004808)2.39013928
85Abnormality of the fingertips (HP:0001211)2.38239624
86Increased IgE level (HP:0003212)2.37648874
87Osteomyelitis (HP:0002754)2.35973866
88Basal ganglia calcification (HP:0002135)2.25179418
89Emphysema (HP:0002097)2.24798062
90Encephalitis (HP:0002383)2.23662842
91Epistaxis (HP:0000421)2.23498724
92Increased serum ferritin (HP:0003281)2.21720100
93Osteolytic defects of the hand bones (HP:0009699)2.19905364
94Osteolytic defects of the phalanges of the hand (HP:0009771)2.19905364
95Hypergammaglobulinemia (HP:0010702)2.18950948
96Glomerulopathy (HP:0100820)2.18818193
97Amyloidosis (HP:0011034)2.17919809
98Abnormality of the prostate (HP:0008775)2.16859466
99Abnormality of polysaccharide metabolism (HP:0011012)2.13353033
100Abnormality of glycosaminoglycan metabolism (HP:0004371)2.13353033
101Abnormality of mucopolysaccharide metabolism (HP:0011020)2.13353033
102Lymphoma (HP:0002665)2.12331412
103Granulocytopenia (HP:0001913)2.12009931
104Eosinophilia (HP:0001880)2.11294146
105Abnormality of the peritoneum (HP:0002585)2.10869953
106Vertigo (HP:0002321)2.10470073
107Joint swelling (HP:0001386)2.10450324
108Increased neuronal autofluorescent lipopigment (HP:0002074)2.09684124
109Keratitis (HP:0000491)2.09637303
110Abnormality of the endocardium (HP:0004306)2.09411839
111Abnormality of the pericardium (HP:0001697)2.08396965
112Arthralgia (HP:0002829)2.05526512
113Hematochezia (HP:0002573)2.05379176
114Mucopolysacchariduria (HP:0008155)2.04536333
115Urinary glycosaminoglycan excretion (HP:0003541)2.04536333
116Skin ulcer (HP:0200042)2.03434219
117Restrictive lung disease (HP:0002091)2.01415602
118Pulmonary embolism (HP:0002204)2.00673240
119Premature loss of primary teeth (HP:0006323)1.98833436
120Frequent falls (HP:0002359)1.95509559
121Petechiae (HP:0000967)1.94939836
122Polycythemia (HP:0001901)1.94828601
123Thyroiditis (HP:0100646)1.94725598
124Thrombophlebitis (HP:0004418)1.92412763
125Acne (HP:0001061)1.91873119
126Abnormality of eosinophils (HP:0001879)1.91586295
127Abnormality of the pleura (HP:0002103)1.90327734
128Gangrene (HP:0100758)1.90025318
129Episodic fever (HP:0001954)1.89711430
130Segmental peripheral demyelination/remyelination (HP:0003481)1.89372653
131Purpura (HP:0000979)1.87753599

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.55418718
2MAP3K144.02984677
3TXK3.94774782
4JAK33.50987732
5PRPF4B3.02413839
6ZAP702.94887825
7TBK12.60592086
8TYK22.55072283
9IKBKE2.27323389
10MATK2.23552346
11MAP2K32.22475685
12EEF2K2.20713823
13IRAK32.13972652
14* IKBKB2.07971924
15BMPR22.02339885
16PIM21.96011055
17DDR21.85359364
18GRK71.84425875
19RPS6KA41.83585893
20IRAK41.79161207
21JAK11.77690239
22* CHUK1.70430570
23BLK1.70429516
24RIPK41.68291647
25TEC1.65345496
26BTK1.64089292
27KIT1.58881989
28ITK1.58051567
29CSK1.55104866
30FGR1.53167756
31MAP3K101.50222690
32MAP3K111.48798335
33FGFR41.46737948
34RIPK11.44139971
35TRIB31.43701247
36CDK121.43312948
37STK101.43040453
38MAP3K31.41812425
39ERN11.40422822
40TAOK11.37686801
41EPHB11.36087431
42LCK1.34306164
43SYK1.34070549
44HCK1.30255257
45PIM11.29760350
46CDC42BPA1.24224628
47MAP3K131.22604580
48FGFR31.19070471
49NLK1.16761481
50IRAK21.12804641
51TAOK21.09937626
52MOS1.09845269
53TGFBR21.09344079
54JAK21.06639645
55PKN20.99056545
56EPHA30.96912784
57TAOK30.96737083
58CSF1R0.95650360
59LRRK20.95000772
60LYN0.93777925
61SMG10.87440446
62MAP3K70.86270804
63FES0.84359435
64NME20.83783546
65PTK60.83721567
66MAP3K50.78995911
67TRPM70.75142616
68TSSK60.71899134
69TTN0.70830309
70MST40.70041637
71GRK60.68267967
72TYRO30.67829562
73ALK0.67120901
74SIK10.66859743
75TGFBR10.64495304
76FLT30.64405509
77MARK30.62993584
78NEK90.61198880
79CLK10.58824004
80SIK20.58615014
81PRKCQ0.58454549
82MAPK110.58021307
83MAPKAPK20.57096083
84RAF10.56556018
85CDK40.55188395
86MAP3K80.54039072
87CDK60.53939170
88MAP3K10.53818017
89SIK30.51975767
90PDGFRB0.51534506
91IRAK10.51353152
92ARAF0.49095718
93PASK0.48041658
94PDGFRA0.48023689
95EGFR0.46543632
96ABL10.46520700
97PDK10.45914849
98DMPK0.45905102
99STK40.45881514
100BMX0.44739128
101RPS6KA10.42748656
102BRD40.41715472
103RPS6KA50.40991978
104HIPK20.40967607
105STK240.39635911
106PRKCH0.39346177
107ICK0.39263345
108MAPK70.37231115
109STK30.36889523
110CDK90.35698078
111KSR20.34100244
112PAK20.33975490
113MELK0.33804729
114PDPK10.32995542
115NUAK10.32293435
116MAPK40.32142731
117ADRBK20.30215278
118RPS6KL10.29297766
119RPS6KC10.29297766
120MTOR0.28964031
121INSR0.28397104
122KDR0.28380104
123RPS6KA60.27709032
124GSK3A0.26793893
125IGF1R0.25167099
126MARK20.25081891
127MAP2K60.24954323
128TESK20.22188350

Predicted pathways (KEGG)

RankGene SetZ-score
1* NF-kappa B signaling pathway_Homo sapiens_hsa040643.15033722
2Allograft rejection_Homo sapiens_hsa053303.11044769
3Primary immunodeficiency_Homo sapiens_hsa053402.99004121
4* Leishmaniasis_Homo sapiens_hsa051402.89316777
5* Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.70008638
6Graft-versus-host disease_Homo sapiens_hsa053322.61373560
7* Measles_Homo sapiens_hsa051622.53838205
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.45826612
9* Osteoclast differentiation_Homo sapiens_hsa043802.34943796
10Asthma_Homo sapiens_hsa053102.32291893
11* T cell receptor signaling pathway_Homo sapiens_hsa046602.16638624
12* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.08403626
13* NOD-like receptor signaling pathway_Homo sapiens_hsa046212.02710847
14* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.98120003
15Type I diabetes mellitus_Homo sapiens_hsa049401.93425232
16* B cell receptor signaling pathway_Homo sapiens_hsa046621.92172748
17Jak-STAT signaling pathway_Homo sapiens_hsa046301.91894046
18Antigen processing and presentation_Homo sapiens_hsa046121.90479111
19* Legionellosis_Homo sapiens_hsa051341.88730401
20* TNF signaling pathway_Homo sapiens_hsa046681.88472773
21Hematopoietic cell lineage_Homo sapiens_hsa046401.88212445
22Autoimmune thyroid disease_Homo sapiens_hsa053201.86884394
23* Toxoplasmosis_Homo sapiens_hsa051451.81589857
24* Herpes simplex infection_Homo sapiens_hsa051681.78426565
25Malaria_Homo sapiens_hsa051441.74693556
26* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.71261957
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.68219450
28* Influenza A_Homo sapiens_hsa051641.67000889
29* Tuberculosis_Homo sapiens_hsa051521.50280517
30Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49187885
31Viral myocarditis_Homo sapiens_hsa054161.46808881
32Staphylococcus aureus infection_Homo sapiens_hsa051501.45306748
33* Pertussis_Homo sapiens_hsa051331.44331622
34* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.37945875
35Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.35785777
36* Acute myeloid leukemia_Homo sapiens_hsa052211.35653541
37* Hepatitis B_Homo sapiens_hsa051611.31129453
38* Apoptosis_Homo sapiens_hsa042101.30341263
39* Chronic myeloid leukemia_Homo sapiens_hsa052201.27447182
40* AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25508909
41Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.21013289
42* Chemokine signaling pathway_Homo sapiens_hsa040621.18917786
43* Shigellosis_Homo sapiens_hsa051311.10100256
44Rheumatoid arthritis_Homo sapiens_hsa053231.07925023
45African trypanosomiasis_Homo sapiens_hsa051431.05674802
46* Prolactin signaling pathway_Homo sapiens_hsa049171.05357970
47Prion diseases_Homo sapiens_hsa050201.00103261
48Leukocyte transendothelial migration_Homo sapiens_hsa046700.98253057
49* Epstein-Barr virus infection_Homo sapiens_hsa051690.97681150
50* Salmonella infection_Homo sapiens_hsa051320.97034984
51* Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96055465
52* Hepatitis C_Homo sapiens_hsa051600.94516748
53* HTLV-I infection_Homo sapiens_hsa051660.93973687
54* Small cell lung cancer_Homo sapiens_hsa052220.93496584
55* Viral carcinogenesis_Homo sapiens_hsa052030.87332259
56Bladder cancer_Homo sapiens_hsa052190.84989924
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81989739
58One carbon pool by folate_Homo sapiens_hsa006700.78984502
59Platelet activation_Homo sapiens_hsa046110.77686314
60* Neurotrophin signaling pathway_Homo sapiens_hsa047220.76450635
61* Pancreatic cancer_Homo sapiens_hsa052120.73902588
62* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68244636
63* Adipocytokine signaling pathway_Homo sapiens_hsa049200.63983197
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62030463
65* Amoebiasis_Homo sapiens_hsa051460.58205912
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57761933
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56200584
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55558716
69* MicroRNAs in cancer_Homo sapiens_hsa052060.54939547
70VEGF signaling pathway_Homo sapiens_hsa043700.53457695
71Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.51048327
72Notch signaling pathway_Homo sapiens_hsa043300.49049735
73p53 signaling pathway_Homo sapiens_hsa041150.48289410
74* Insulin resistance_Homo sapiens_hsa049310.44909936
75* MAPK signaling pathway_Homo sapiens_hsa040100.43504501
76Systemic lupus erythematosus_Homo sapiens_hsa053220.42916290
77Colorectal cancer_Homo sapiens_hsa052100.42627642
78Proteoglycans in cancer_Homo sapiens_hsa052050.42010467
79Dorso-ventral axis formation_Homo sapiens_hsa043200.41221440
80Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.39020559
81FoxO signaling pathway_Homo sapiens_hsa040680.38310516
82Glycosaminoglycan degradation_Homo sapiens_hsa005310.38118578
83* HIF-1 signaling pathway_Homo sapiens_hsa040660.35759495
84Phagosome_Homo sapiens_hsa041450.35756715
85Sphingolipid metabolism_Homo sapiens_hsa006000.35406256
86Non-small cell lung cancer_Homo sapiens_hsa052230.34799047
87Lysosome_Homo sapiens_hsa041420.34669543
88Other glycan degradation_Homo sapiens_hsa005110.33953620
89Complement and coagulation cascades_Homo sapiens_hsa046100.32104918
90Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.29961633
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.28117601
92Thyroid cancer_Homo sapiens_hsa052160.26840460
93Endometrial cancer_Homo sapiens_hsa052130.26782405
94Central carbon metabolism in cancer_Homo sapiens_hsa052300.26692392
95Base excision repair_Homo sapiens_hsa034100.26341768
96* Prostate cancer_Homo sapiens_hsa052150.25191614
97mTOR signaling pathway_Homo sapiens_hsa041500.24811686
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.24493044
99Focal adhesion_Homo sapiens_hsa045100.24251367
100ErbB signaling pathway_Homo sapiens_hsa040120.23820097
101* Pathways in cancer_Homo sapiens_hsa052000.23698493
102SNARE interactions in vesicular transport_Homo sapiens_hsa041300.23631747
103Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.23252181
104Renal cell carcinoma_Homo sapiens_hsa052110.21968961
105* Sphingolipid signaling pathway_Homo sapiens_hsa040710.21699731
106GnRH signaling pathway_Homo sapiens_hsa049120.21452723
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.21354358
108Lysine degradation_Homo sapiens_hsa003100.20778984
109Endocytosis_Homo sapiens_hsa041440.20597691
110Spliceosome_Homo sapiens_hsa030400.20006632
111Type II diabetes mellitus_Homo sapiens_hsa049300.19432025
112* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19404328
113Carbohydrate digestion and absorption_Homo sapiens_hsa049730.18668535
114Adherens junction_Homo sapiens_hsa045200.18281577
115Glioma_Homo sapiens_hsa052140.12368601
116Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.11095476

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