NFKB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous antigen (GO:0019883)5.63999542
2positive regulation of gamma-delta T cell activation (GO:0046645)5.37248850
3regulation of interleukin-12 biosynthetic process (GO:0045075)5.33095233
4antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.25461974
5antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.25461974
6regulation of vitamin D biosynthetic process (GO:0060556)4.56914356
7* NIK/NF-kappaB signaling (GO:0038061)4.53983657
8response to muramyl dipeptide (GO:0032495)4.15718913
9regulation of gamma-delta T cell activation (GO:0046643)4.15196179
10regulation of gamma-delta T cell differentiation (GO:0045586)4.13802508
11positive regulation of interleukin-2 biosynthetic process (GO:0045086)4.10165885
12regulation of dendritic cell antigen processing and presentation (GO:0002604)4.07755785
13positive regulation of natural killer cell differentiation (GO:0032825)3.95639670
14myeloid dendritic cell differentiation (GO:0043011)3.89684338
15JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.84314477
16positive thymic T cell selection (GO:0045059)3.81633679
17negative thymic T cell selection (GO:0045060)3.77772915
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.77765872
19T-helper 1 type immune response (GO:0042088)3.75267245
20negative T cell selection (GO:0043383)3.62106531
21regulation of vitamin metabolic process (GO:0030656)3.61012507
22modulation by symbiont of host immune response (GO:0052553)3.59566767
23positive regulation by symbiont of host defense response (GO:0052509)3.59566767
24modulation by symbiont of host defense response (GO:0052031)3.59566767
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.59566767
26modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.59566767
27positive regulation by organism of defense response of other organism involved in symbiotic interact3.59566767
28regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.55499138
29response to type I interferon (GO:0034340)3.54651156
30positive regulation of antigen processing and presentation (GO:0002579)3.52413154
31positive regulation of humoral immune response (GO:0002922)3.51346938
32myeloid dendritic cell activation (GO:0001773)3.51313099
33cellular response to type I interferon (GO:0071357)3.51031655
34type I interferon signaling pathway (GO:0060337)3.51031655
35interferon-gamma-mediated signaling pathway (GO:0060333)3.50828406
36CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.46580115
37regulation of cytokine secretion involved in immune response (GO:0002739)3.45354055
38immunoglobulin mediated immune response (GO:0016064)3.42183764
39positive regulation of interferon-alpha production (GO:0032727)3.41901499
40positive regulation of interleukin-12 production (GO:0032735)3.37686593
41negative regulation of cytokine production involved in immune response (GO:0002719)3.36975346
42tolerance induction (GO:0002507)3.36193242
43regulation of interferon-alpha production (GO:0032647)3.31491609
44regulation of podosome assembly (GO:0071801)3.30614584
45detection of other organism (GO:0098543)3.27417353
46regulation of T-helper 1 cell differentiation (GO:0045625)3.25224968
47positive regulation of interleukin-2 production (GO:0032743)3.23687870
48thymic T cell selection (GO:0045061)3.23297443
49neutrophil activation involved in immune response (GO:0002283)3.23253875
50detection of bacterium (GO:0016045)3.21545910
51T cell migration (GO:0072678)3.19592565
52negative regulation of interleukin-12 production (GO:0032695)3.19489590
53regulation of interleukin-12 production (GO:0032655)3.19296674
54regulation of type I interferon-mediated signaling pathway (GO:0060338)3.17913876
55leukocyte aggregation (GO:0070486)3.15390834
56regulation of alpha-beta T cell proliferation (GO:0046640)3.13979151
57response to interleukin-15 (GO:0070672)3.12088461
58positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.11296318
59regulation of antigen processing and presentation (GO:0002577)3.11120698
60growth hormone receptor signaling pathway (GO:0060396)3.11104492
61dendritic cell differentiation (GO:0097028)3.11077039
62positive regulation of type 2 immune response (GO:0002830)3.07558446
63positive regulation of B cell differentiation (GO:0045579)3.07363784
64regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.03754461
65modulation by symbiont of host cellular process (GO:0044068)3.01908212
66defense response to protozoan (GO:0042832)3.01140132
67response to peptidoglycan (GO:0032494)3.01075121
68regulation of chemokine biosynthetic process (GO:0045073)2.99111854
69negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.97904401
70regulation of interleukin-2 biosynthetic process (GO:0045076)2.97765207
71activation of MAPKKK activity (GO:0000185)2.97533548
72T cell selection (GO:0045058)2.97366949
73natural killer cell mediated immunity (GO:0002228)2.95754910
74natural killer cell mediated cytotoxicity (GO:0042267)2.95754910
75negative regulation of erythrocyte differentiation (GO:0045647)2.95107744
76positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.93808943
77regulation of response to interferon-gamma (GO:0060330)2.93577915
78regulation of T-helper 2 cell differentiation (GO:0045628)2.92495930
79positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.92249358
80negative regulation of cell killing (GO:0031342)2.92198181
81negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.92198181
82negative regulation of myeloid cell apoptotic process (GO:0033033)2.91648945
83regulation of B cell receptor signaling pathway (GO:0050855)2.89513591
84positive regulation of cytokine biosynthetic process (GO:0042108)2.89440907
85positive regulation of heat generation (GO:0031652)2.89156080
86positive regulation of isotype switching (GO:0045830)2.87856915
87* germinal center formation (GO:0002467)2.87756403
88regulation of interferon-beta biosynthetic process (GO:0045357)2.87288568
89mature B cell differentiation (GO:0002335)2.87095238
90positive regulation of NF-kappaB import into nucleus (GO:0042346)2.86127800
91response to protozoan (GO:0001562)2.83571618
92granulocyte activation (GO:0036230)2.82396748
93hepatocyte apoptotic process (GO:0097284)2.82279422
94positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.80434044
95neutrophil activation (GO:0042119)2.80225397
96positive T cell selection (GO:0043368)2.79654083
97regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.79024824
98positive regulation of immunoglobulin mediated immune response (GO:0002891)2.78556016
99positive regulation of B cell mediated immunity (GO:0002714)2.78556016
100detection of external biotic stimulus (GO:0098581)2.78147823
101regulation of interferon-gamma-mediated signaling pathway (GO:0060334)2.77393311
102positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.77333169
103B cell mediated immunity (GO:0019724)2.77265124
104lipopolysaccharide-mediated signaling pathway (GO:0031663)2.77057499
105regulation of B cell differentiation (GO:0045577)2.76460891
106regulation of RIG-I signaling pathway (GO:0039535)2.76141772
107detection of molecule of bacterial origin (GO:0032490)2.75697880
108negative regulation of T cell mediated immunity (GO:0002710)2.74549210
109regulation of chronic inflammatory response (GO:0002676)2.73496885
110positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.73335091
111regulation of T cell tolerance induction (GO:0002664)2.73332946
112natural killer cell differentiation (GO:0001779)2.72750620
113macrophage activation involved in immune response (GO:0002281)2.72687403
114cellular response to interferon-gamma (GO:0071346)2.72341368
115positive regulation of interleukin-17 production (GO:0032740)2.71734689
116leukocyte cell-cell adhesion (GO:0007159)2.71646124
117regulation of necroptotic process (GO:0060544)2.70582379
118regulation of membrane protein ectodomain proteolysis (GO:0051043)2.70531147
119regulation of immunoglobulin secretion (GO:0051023)2.70184878
120regulation of fever generation (GO:0031620)2.69761302
121regulation of T-helper cell differentiation (GO:0045622)2.69571854
122response to host immune response (GO:0052572)2.69183924
123response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.69183924
124cellular response to lipopolysaccharide (GO:0071222)2.68471102
125regulation of type 2 immune response (GO:0002828)2.67396940
126response to interferon-gamma (GO:0034341)2.66765363
127cellular response to zinc ion (GO:0071294)2.65430947
128regulation of interferon-gamma biosynthetic process (GO:0045072)2.65291048
129regulation of natural killer cell differentiation (GO:0032823)2.65151788
130cytokine secretion (GO:0050663)2.64716245
131positive regulation of chemokine biosynthetic process (GO:0045080)2.63933149
132cellular response to interleukin-15 (GO:0071350)2.63812766
133respiratory burst (GO:0045730)2.63783000
134cellular response to molecule of bacterial origin (GO:0071219)2.63516043
135positive regulation of interferon-beta production (GO:0032728)2.63455539
136negative regulation of production of molecular mediator of immune response (GO:0002701)2.62429703

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.26509516
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.88025224
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.16575954
4EGR1_19374776_ChIP-ChIP_THP-1_Human4.14567879
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.99761611
6* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.76707199
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.61234328
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.48019239
9* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.07939798
10IRF8_27001747_Chip-Seq_BMDM_Mouse2.92048120
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.91270231
12BP1_19119308_ChIP-ChIP_Hs578T_Human2.86898553
13TP63_17297297_ChIP-ChIP_HaCaT_Human2.84597300
14* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.81722981
15STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.77576436
16NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.71732581
17* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.69873690
18* MYC_22102868_ChIP-Seq_BL_Human2.68651083
19* STAT4_19710469_ChIP-ChIP_TH1__Mouse2.68574434
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.56796366
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.44066463
22VDR_21846776_ChIP-Seq_THP-1_Human2.39297286
23* MAF_26560356_Chip-Seq_TH1_Human2.34968821
24MYB_26560356_Chip-Seq_TH2_Human2.22184611
25RUNX_20019798_ChIP-Seq_JUKART_Human2.13676779
26FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.13521699
27MYB_26560356_Chip-Seq_TH1_Human2.00606210
28BRD4_27068464_Chip-Seq_AML-cells_Mouse1.99588657
29VDR_24763502_ChIP-Seq_THP-1_Human1.97157719
30* TCF7_22412390_ChIP-Seq_EML_Mouse1.96346721
31NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.95270532
32Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.81639917
33* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.79761068
34* UTX_26944678_Chip-Seq_JUKART_Human1.78436262
35* ELK3_25401928_ChIP-Seq_HUVEC_Human1.75786497
36E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.70465276
37* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.68796372
38E2F7_22180533_ChIP-Seq_HELA_Human1.68735491
39* SPI1_23547873_ChIP-Seq_NB4_Human1.68368264
40* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.66815618
41STAT6_21828071_ChIP-Seq_BEAS2B_Human1.66711990
42* RUNX1_22412390_ChIP-Seq_EML_Mouse1.64321443
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.61831397
44* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59235006
45* KDM2B_26808549_Chip-Seq_DND41_Human1.57798256
46SCL_19346495_ChIP-Seq_HPC-7_Human1.51950057
47MAF_26560356_Chip-Seq_TH2_Human1.49921689
48SPI1_23127762_ChIP-Seq_K562_Human1.49020314
49RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.46714268
50THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41976816
51SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.41345039
52PU_27001747_Chip-Seq_BMDM_Mouse1.36800705
53GATA3_27048872_Chip-Seq_THYMUS_Human1.35734514
54PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32997448
55VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.32078420
56TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30938788
57STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22849852
58NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.22408853
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.21345456
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.15350092
61VDR_24787735_ChIP-Seq_THP-1_Human1.14427714
62CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13587791
63CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13403074
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.13400322
65* GATA1_19941827_ChIP-Seq_MEL_Mouse1.12951022
66* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.12836179
67GATA1_22025678_ChIP-Seq_K562_Human1.12791314
68PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11058409
69TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10864309
70TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.10721094
71CLOCK_20551151_ChIP-Seq_293T_Human1.10715300
72RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10653168
73RARG_19884340_ChIP-ChIP_MEFs_Mouse1.07279152
74FOXO3_23340844_ChIP-Seq_DLD1_Human1.06224432
75* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.05865158
76MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.05372719
77LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05019077
78* BCOR_27268052_Chip-Seq_Bcells_Human1.03893366
79SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.03482440
80SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.03482440
81NCOR1_26117541_ChIP-Seq_K562_Human1.03107083
82KDM2B_26808549_Chip-Seq_K562_Human1.02312059
83SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02036129
84GATA2_21666600_ChIP-Seq_HMVEC_Human1.01927445
85GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00853955
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98844649
87TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98521974
88ATF3_27146783_Chip-Seq_COLON_Human0.96690831
89ELF1_20517297_ChIP-Seq_JURKAT_Human0.96509130
90GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.96307377
91* BCL6_27268052_Chip-Seq_Bcells_Human0.95787218
92GATA1_19941826_ChIP-Seq_K562_Human0.95764882
93SA1_27219007_Chip-Seq_ERYTHROID_Human0.94892387
94GATA3_26560356_Chip-Seq_TH2_Human0.94073358
95* FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93491044
96PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.92666070
97RACK7_27058665_Chip-Seq_MCF-7_Human0.92165601
98* KDM2B_26808549_Chip-Seq_JURKAT_Human0.92053739
99GATA1_22383799_ChIP-Seq_G1ME_Mouse0.91665785
100LXR_22292898_ChIP-Seq_THP-1_Human0.91588470
101SMAD_19615063_ChIP-ChIP_OVARY_Human0.90109395
102ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.89580595
103TFEB_21752829_ChIP-Seq_HELA_Human0.89417509
104CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88994222
105SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88293877
106STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86978321
107* HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86255435
108TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.85625986
109CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85051481
110PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.84667125
111KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.83745023
112JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82911910
113FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.82425628
114* UBF1/2_26484160_Chip-Seq_HMECs_Human0.81659981
115SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81314817
116PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79287504

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.02237063
2MP0000685_abnormal_immune_system3.79894391
3MP0003303_peritoneal_inflammation3.42549994
4MP0001790_abnormal_immune_system3.30305366
5MP0005387_immune_system_phenotype3.30305366
6MP0003436_decreased_susceptibility_to3.29583079
7MP0004510_myositis3.23800926
8MP0009785_altered_susceptibility_to2.97089500
9* MP0001800_abnormal_humoral_immune2.88961398
10* MP0005000_abnormal_immune_tolerance2.84162634
11MP0005671_abnormal_response_to2.77907569
12* MP0002452_abnormal_antigen_presenting2.57277230
13MP0002254_reproductive_system_inflammat2.53354277
14MP0003300_gastrointestinal_ulcer2.48212874
15* MP0002723_abnormal_immune_serum2.45431662
16MP0002148_abnormal_hypersensitivity_rea2.44389157
17MP0005451_abnormal_body_composition2.41682932
18* MP0005025_abnormal_response_to2.38838931
19MP0002419_abnormal_innate_immunity2.27007956
20* MP0001819_abnormal_immune_cell2.22871373
21* MP0002420_abnormal_adaptive_immunity2.22469712
22MP0004947_skin_inflammation2.19144892
23MP0006082_CNS_inflammation2.12707134
24MP0002166_altered_tumor_susceptibility2.07191334
25* MP0002405_respiratory_system_inflammati2.03034905
26* MP0003763_abnormal_thymus_physiology2.00935540
27MP0002138_abnormal_hepatobiliary_system1.99580642
28MP0010155_abnormal_intestine_physiology1.99101803
29MP0010352_gastrointestinal_tract_polyps1.95995405
30MP0001853_heart_inflammation1.95248418
31* MP0002398_abnormal_bone_marrow1.93184212
32MP0001873_stomach_inflammation1.89819898
33MP0002006_tumorigenesis1.87893350
34MP0003724_increased_susceptibility_to1.86798955
35MP0009278_abnormal_bone_marrow1.84134168
36* MP0000716_abnormal_immune_system1.82017514
37MP0001348_abnormal_lacrimal_gland1.69724058
38* MP0001845_abnormal_inflammatory_respons1.67703786
39MP0005310_abnormal_salivary_gland1.67115302
40MP0005076_abnormal_cell_differentiation1.66516585
41MP0001533_abnormal_skeleton_physiology1.65234173
42MP0005464_abnormal_platelet_physiology1.55878704
43* MP0000689_abnormal_spleen_morphology1.54602509
44MP0003448_altered_tumor_morphology1.52802578
45* MP0002722_abnormal_immune_system1.50749127
46* MP0002429_abnormal_blood_cell1.49770741
47MP0002139_abnormal_hepatobiliary_system1.42124819
48MP0001545_abnormal_hematopoietic_system1.41513485
49MP0005397_hematopoietic_system_phenotyp1.41513485
50MP0003705_abnormal_hypodermis_morpholog1.39798883
51MP0002396_abnormal_hematopoietic_system1.36700321
52MP0004808_abnormal_hematopoietic_stem1.35520787
53MP0002933_joint_inflammation1.35308898
54* MP0009333_abnormal_splenocyte_physiolog1.35133293
55MP0003453_abnormal_keratinocyte_physiol1.32913603
56MP0008260_abnormal_autophagy1.31302770
57MP0003566_abnormal_cell_adhesion1.30918149
58MP0000858_altered_metastatic_potential1.30404907
59* MP0000703_abnormal_thymus_morphology1.28797020
60MP0002877_abnormal_melanocyte_morpholog1.28221022
61MP0008004_abnormal_stomach_pH1.27560511
62MP0003866_abnormal_defecation1.25624052
63MP0008469_abnormal_protein_level1.24502377
64MP0002332_abnormal_exercise_endurance1.15445771
65MP0002998_abnormal_bone_remodeling1.14467820
66* MP0003091_abnormal_cell_migration1.11357838
67MP0005023_abnormal_wound_healing1.11104544
68MP0009764_decreased_sensitivity_to1.10509640
69MP0010307_abnormal_tumor_latency1.09322038
70MP0009840_abnormal_foam_cell1.08961074
71MP0005058_abnormal_lysosome_morphology1.03126456
72MP0005167_abnormal_blood-brain_barrier0.98742549
73MP0000343_altered_response_to0.97857772
74MP0003656_abnormal_erythrocyte_physiolo0.96014624
75MP0000569_abnormal_digit_pigmentation0.94825440
76MP0003045_fibrosis0.90969666
77MP0001851_eye_inflammation0.90843974
78MP0003806_abnormal_nucleotide_metabolis0.90678259
79MP0003172_abnormal_lysosome_physiology0.89350341
80MP0000604_amyloidosis0.84148189
81MP0000733_abnormal_muscle_development0.83868532
82MP0005390_skeleton_phenotype0.83753569
83MP0000490_abnormal_crypts_of0.81693401
84MP0005164_abnormal_response_to0.80783210
85MP0003183_abnormal_peptide_metabolism0.78918902
86MP0003828_pulmonary_edema0.78159373
87MP0002277_abnormal_respiratory_mucosa0.77790652
88MP0000767_abnormal_smooth_muscle0.74955906
89MP0003690_abnormal_glial_cell0.74435606
90MP0009765_abnormal_xenobiotic_induced0.74280501
91MP0001849_ear_inflammation0.73826365
92MP0001881_abnormal_mammary_gland0.73063405
93MP0000249_abnormal_blood_vessel0.72550892
94* MP0009763_increased_sensitivity_to0.72546600
95MP0000465_gastrointestinal_hemorrhage0.72152499
96MP0002019_abnormal_tumor_incidence0.71849918
97MP0003075_altered_response_to0.71718155
98MP0008874_decreased_physiological_sensi0.71100979
99MP0008057_abnormal_DNA_replication0.69308344
100MP0001958_emphysema0.66531179
101MP0006054_spinal_hemorrhage0.66464994
102MP0003191_abnormal_cellular_cholesterol0.65921142
103MP0003221_abnormal_cardiomyocyte_apopto0.65510512
104MP0008438_abnormal_cutaneous_collagen0.65341745
105MP0001216_abnormal_epidermal_layer0.63604366
106MP0001243_abnormal_dermal_layer0.62027736
107* MP0003795_abnormal_bone_structure0.61834881
108MP0005666_abnormal_adipose_tissue0.61327488
109* MP0002136_abnormal_kidney_physiology0.59863467
110MP0004883_abnormal_blood_vessel0.59157674
111* MP0000609_abnormal_liver_physiology0.58844933
112MP0003279_aneurysm0.58173018
113MP0001663_abnormal_digestive_system0.57845395
114MP0005165_increased_susceptibility_to0.57800188
115MP0005166_decreased_susceptibility_to0.57778342
116MP0001346_abnormal_lacrimal_gland0.56685065
117MP0000371_diluted_coat_color0.56126275
118MP0001191_abnormal_skin_condition0.56083953
119MP0000627_abnormal_mammary_gland0.55563809

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.50680660
2Elevated erythrocyte sedimentation rate (HP:0003565)4.97596286
3Recurrent fungal infections (HP:0002841)4.45974732
4Abnormality of glycolipid metabolism (HP:0010969)4.40584720
5Abnormality of liposaccharide metabolism (HP:0010968)4.40584720
6Abnormality of glycosphingolipid metabolism (HP:0004343)4.40584720
7Recurrent abscess formation (HP:0002722)4.38086805
8Stomatitis (HP:0010280)4.32159720
9Myositis (HP:0100614)4.13706623
10Recurrent bacterial skin infections (HP:0005406)4.04161587
11Mediastinal lymphadenopathy (HP:0100721)3.98824687
12Recurrent viral infections (HP:0004429)3.92649905
13Orchitis (HP:0100796)3.92410757
14Optic neuritis (HP:0100653)3.82823162
15Retrobulbar optic neuritis (HP:0100654)3.82823162
16Recurrent cutaneous fungal infections (HP:0011370)3.81387780
17Chronic mucocutaneous candidiasis (HP:0002728)3.81387780
18Chronic otitis media (HP:0000389)3.63685490
19Recurrent bronchitis (HP:0002837)3.41543414
20Abnormal delayed hypersensitivity skin test (HP:0002963)3.40297728
21Autoimmune thrombocytopenia (HP:0001973)3.40245959
22Nasal polyposis (HP:0100582)3.39971707
23Loss of speech (HP:0002371)3.37451647
24Recurrent skin infections (HP:0001581)3.32155580
25Pulmonary infiltrates (HP:0002113)3.27596069
26Dysostosis multiplex (HP:0000943)3.24071287
27* Vasculitis (HP:0002633)3.23643243
28Interstitial pulmonary disease (HP:0006530)3.22803046
29Abnormality of macrophages (HP:0004311)3.20732067
30Cellulitis (HP:0100658)3.20637720
31Systemic lupus erythematosus (HP:0002725)3.18424749
32Colitis (HP:0002583)3.13267493
33Increased density of long bones (HP:0006392)3.10472228
34Vacuolated lymphocytes (HP:0001922)3.07200702
35Arterial thrombosis (HP:0004420)3.05321330
36Abnormality of the nasal mucosa (HP:0000433)3.05043615
37Recurrent gram-negative bacterial infections (HP:0005420)3.03496354
38Increased IgE level (HP:0003212)3.00974290
39Abnormality of T cell number (HP:0011839)2.99256756
40Agammaglobulinemia (HP:0004432)2.99073538
41Gastrointestinal infarctions (HP:0005244)2.98965761
42Inflammation of the large intestine (HP:0002037)2.97649714
43Pustule (HP:0200039)2.89359725
44Gastrointestinal inflammation (HP:0004386)2.87842463
45Increased IgM level (HP:0003496)2.86007174
46Persistence of primary teeth (HP:0006335)2.85678411
47Panhypogammaglobulinemia (HP:0003139)2.83439103
48Gingivitis (HP:0000230)2.82696522
49Keratoconjunctivitis (HP:0001096)2.79114384
50Myocardial infarction (HP:0001658)2.77643918
51T lymphocytopenia (HP:0005403)2.77325451
52Peritonitis (HP:0002586)2.76937905
53Thrombocytosis (HP:0001894)2.72940150
54Hematochezia (HP:0002573)2.71554041
55Meningitis (HP:0001287)2.71107144
56Leukocytosis (HP:0001974)2.67469371
57Abnormality of T cells (HP:0002843)2.65260857
58Periodontitis (HP:0000704)2.63798307
59IgA deficiency (HP:0002720)2.59914529
60Increased neuronal autofluorescent lipopigment (HP:0002074)2.59689689
61Hypergammaglobulinemia (HP:0010702)2.56735804
62Osteomyelitis (HP:0002754)2.54566379
63Increased serum ferritin (HP:0003281)2.52664157
64Abnormality of T cell physiology (HP:0011840)2.51154515
65Keratoconjunctivitis sicca (HP:0001097)2.47912379
66Autoimmune hemolytic anemia (HP:0001890)2.47492150
67Osteolytic defects of the hand bones (HP:0009699)2.45716589
68Osteolytic defects of the phalanges of the hand (HP:0009771)2.45716589
69Disinhibition (HP:0000734)2.45664493
70Gangrene (HP:0100758)2.44794844
71Hemoptysis (HP:0002105)2.44134943
72* Emphysema (HP:0002097)2.40208803
73Abnormality of polysaccharide metabolism (HP:0011012)2.40145067
74Abnormality of glycosaminoglycan metabolism (HP:0004371)2.40145067
75Abnormality of mucopolysaccharide metabolism (HP:0011020)2.40145067
76Chronic obstructive pulmonary disease (HP:0006510)2.39990574
77Obstructive lung disease (HP:0006536)2.39990574
78IgM deficiency (HP:0002850)2.38033858
79Nuclear cataract (HP:0100018)2.33973315
80Fatigue (HP:0012378)2.29977943
81Eosinophilia (HP:0001880)2.29820270
82Vertebral compression fractures (HP:0002953)2.29783304
83Abnormality of the fingertips (HP:0001211)2.28763881
84Mucopolysacchariduria (HP:0008155)2.27693821
85Urinary glycosaminoglycan excretion (HP:0003541)2.27693821
86Malnutrition (HP:0004395)2.23054307
87Urticaria (HP:0001025)2.22487026
88Segmental peripheral demyelination/remyelination (HP:0003481)2.21203739
89Spontaneous hematomas (HP:0007420)2.19451969
90Chronic diarrhea (HP:0002028)2.18936512
91Chest pain (HP:0100749)2.17793855
92Skin ulcer (HP:0200042)2.14678253
93Premature loss of primary teeth (HP:0006323)2.14009089
94Gingival bleeding (HP:0000225)2.13816858
95Abnormality of the pleura (HP:0002103)2.10123857
96Thin bony cortex (HP:0002753)2.09758581
97Tetraparesis (HP:0002273)2.08658436
98Purpura (HP:0000979)2.07440482
99Verrucae (HP:0200043)2.07045667
100Papilloma (HP:0012740)2.07045667
101Glomerulonephritis (HP:0000099)2.06173082
102Joint swelling (HP:0001386)2.05276863
103* Restrictive lung disease (HP:0002091)2.04738160
104Thick nail (HP:0001805)2.04646899
105Chronic sinusitis (HP:0011109)2.04516274
106Neuronal loss in central nervous system (HP:0002529)2.04473476
107* Gastrointestinal stroma tumor (HP:0100723)2.02675647
108IgG deficiency (HP:0004315)2.02647361
109Axonal loss (HP:0003447)2.01511319
110Frequent falls (HP:0002359)2.01465559
111Neurofibrillary tangles (HP:0002185)2.00776933
112Basal ganglia calcification (HP:0002135)2.00630882
113Abnormality of eosinophils (HP:0001879)1.99530377
114Amyloidosis (HP:0011034)1.99502745
115Recurrent sinusitis (HP:0011108)1.97907788
116Anorexia (HP:0002039)1.97663550
117Hypertensive crisis (HP:0100735)1.96105324
118Petechiae (HP:0000967)1.95684848
119Esophageal varix (HP:0002040)1.94503626
120Recurrent lower respiratory tract infections (HP:0002783)1.94348757
121Granulocytopenia (HP:0001913)1.93576939
122Polyneuropathy (HP:0001271)1.93460916
123* Abnormality of cells of the lymphoid lineage (HP:0012140)1.92042273
124Hepatosplenomegaly (HP:0001433)1.91239288
125Glomerulopathy (HP:0100820)1.91047363
126Pulmonary embolism (HP:0002204)1.90872326
127Porencephaly (HP:0002132)1.90776133
128Increased cerebral lipofuscin (HP:0011813)1.88469668
129Abnormality of iron homeostasis (HP:0011031)1.88048994
130Recurrent pneumonia (HP:0006532)1.87364846
131Encephalitis (HP:0002383)1.85838642
132* Arthralgia (HP:0002829)1.85769057
133Prostate neoplasm (HP:0100787)1.85266733
134Abnormality of the pericardium (HP:0001697)1.84567958
135Severe combined immunodeficiency (HP:0004430)1.84254709
136Combined immunodeficiency (HP:0005387)1.83113424
137* Lymphopenia (HP:0001888)1.82907748
138Abnormality of the peritoneum (HP:0002585)1.81889262

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K14.09275261
2PRPF4B3.48479382
3JAK33.25324853
4TBK13.20813963
5TYK23.12503372
6* MAP3K142.90212838
7IKBKB2.65859466
8IKBKE2.64051381
9MAP3K102.45868873
10IRAK32.38567477
11TXK2.26637494
12EPHB12.21812335
13JAK12.20952956
14MAP3K132.13263195
15ERN12.12421666
16FGFR42.07776732
17SMG11.92593490
18ZAP701.92592913
19IRAK41.90270312
20TRIB31.90007914
21* CHUK1.81961190
22RPS6KA41.77384433
23BLK1.75610218
24RIPK41.72214061
25DDR21.71714468
26KIT1.71197556
27EPHA31.69139516
28STK101.65916542
29EEF2K1.56841995
30CDK121.52377118
31CDC42BPA1.48287617
32PIM21.46954547
33CSK1.41169578
34TTN1.40598173
35FGFR31.39386487
36BTK1.34880049
37PTK61.33721738
38LRRK21.32620882
39GRK71.30679827
40HCK1.28775193
41ITK1.27237101
42PIM11.26312307
43SYK1.23919373
44MAP2K31.22720369
45CSF1R1.20675646
46LCK1.15968521
47IRAK21.14647305
48GRK61.13398774
49PKN21.12375051
50NLK1.09695719
51BMPR21.09313291
52ICK1.04211771
53JAK21.01557349
54BMX0.99203988
55SIK10.98876405
56TEC0.97651889
57MAP3K30.97502851
58PIK3CG0.92383548
59MARK30.91762052
60SIK20.89303971
61TGFBR20.89135444
62MAP3K110.84514123
63SIK30.83694773
64MST40.82154834
65NME20.80626471
66RIPK10.75570131
67ALK0.75562016
68FLT30.73958662
69TNK20.73331044
70LYN0.69609034
71TAOK30.68280499
72TESK20.66237937
73TYRO30.63470496
74TAOK10.62575506
75MAP3K70.61861816
76MARK20.61597229
77MAPKAPK20.59436677
78NEK90.58356652
79IRAK10.57932951
80PDGFRA0.56595536
81CLK10.55843292
82MAP3K80.55619482
83PDGFRB0.54302599
84EGFR0.53204739
85PRKD20.52300288
86MAPK70.52125987
87RPS6KA50.51555228
88ARAF0.50800319
89MATK0.50167689
90PDK10.49782693
91TGFBR10.49377840
92PDPK10.48920658
93ABL10.48460164
94RPS6KL10.48350600
95RPS6KC10.48350600
96PRKCQ0.47372749
97CDK40.47272634
98MAPK110.46520270
99FGR0.45327244
100MAP3K10.44923527
101RPS6KA10.44567903
102KSR20.44308167
103TRPM70.44292858
104KDR0.42054854
105CDK60.40916982
106MAPK40.40847656
107STK40.39940953
108MAP3K50.38603620
109PAK40.37831891
110INSR0.37786118
111MELK0.36986390
112STK30.36311373
113MTOR0.36004662
114MAP2K60.33419754
115HIPK20.32305750
116RPS6KA60.30587059
117FES0.30459557
118RPS6KA20.30182126
119GSK3A0.29207066
120MAPK120.28862221
121TAOK20.28562251
122TSSK60.26587084
123MOS0.26323815
124PRKCH0.25857439
125CDK90.25622397
126DMPK0.24708727

Predicted pathways (KEGG)

RankGene SetZ-score
1* NF-kappa B signaling pathway_Homo sapiens_hsa040643.05136361
2Leishmaniasis_Homo sapiens_hsa051402.94706347
3Allograft rejection_Homo sapiens_hsa053302.55512463
4Primary immunodeficiency_Homo sapiens_hsa053402.53351352
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.49018902
6Measles_Homo sapiens_hsa051622.42863131
7* Osteoclast differentiation_Homo sapiens_hsa043802.41253348
8Graft-versus-host disease_Homo sapiens_hsa053322.35349471
9B cell receptor signaling pathway_Homo sapiens_hsa046622.31301010
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.20787390
11TNF signaling pathway_Homo sapiens_hsa046682.20722005
12Toll-like receptor signaling pathway_Homo sapiens_hsa046202.20209190
13NOD-like receptor signaling pathway_Homo sapiens_hsa046212.20191848
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.05006888
15Toxoplasmosis_Homo sapiens_hsa051452.01931846
16Antigen processing and presentation_Homo sapiens_hsa046121.98244245
17T cell receptor signaling pathway_Homo sapiens_hsa046601.88001579
18Jak-STAT signaling pathway_Homo sapiens_hsa046301.78493480
19Malaria_Homo sapiens_hsa051441.77156925
20Influenza A_Homo sapiens_hsa051641.76909297
21Asthma_Homo sapiens_hsa053101.73553269
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.69563213
23Herpes simplex infection_Homo sapiens_hsa051681.66533965
24* Legionellosis_Homo sapiens_hsa051341.66321194
25Apoptosis_Homo sapiens_hsa042101.63926683
26Hematopoietic cell lineage_Homo sapiens_hsa046401.57845559
27Acute myeloid leukemia_Homo sapiens_hsa052211.57309684
28Tuberculosis_Homo sapiens_hsa051521.55093393
29Pertussis_Homo sapiens_hsa051331.54352119
30Type I diabetes mellitus_Homo sapiens_hsa049401.46529666
31Chronic myeloid leukemia_Homo sapiens_hsa052201.46050054
32Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.43981010
33AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.42682475
34Shigellosis_Homo sapiens_hsa051311.41507523
35Viral myocarditis_Homo sapiens_hsa054161.39908329
36Hepatitis B_Homo sapiens_hsa051611.39736433
37Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.39296422
38Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.37109076
39Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.34449060
40Small cell lung cancer_Homo sapiens_hsa052221.34431299
41Chemokine signaling pathway_Homo sapiens_hsa040621.34399142
42Autoimmune thyroid disease_Homo sapiens_hsa053201.33541201
43Staphylococcus aureus infection_Homo sapiens_hsa051501.26235269
44Prolactin signaling pathway_Homo sapiens_hsa049171.22642378
45Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.17938996
46Hepatitis C_Homo sapiens_hsa051601.17275168
47Leukocyte transendothelial migration_Homo sapiens_hsa046701.14576023
48African trypanosomiasis_Homo sapiens_hsa051431.14442799
49Salmonella infection_Homo sapiens_hsa051321.12927595
50Pancreatic cancer_Homo sapiens_hsa052121.10049599
51Rheumatoid arthritis_Homo sapiens_hsa053231.07817568
52Prion diseases_Homo sapiens_hsa050201.04775203
53* Epstein-Barr virus infection_Homo sapiens_hsa051690.99588282
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.95245475
55Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.93130348
56Amoebiasis_Homo sapiens_hsa051460.91578630
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.91326883
58Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.90776052
59* Viral carcinogenesis_Homo sapiens_hsa052030.90330849
60* HTLV-I infection_Homo sapiens_hsa051660.90296665
61Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78131717
62VEGF signaling pathway_Homo sapiens_hsa043700.75585283
63MicroRNAs in cancer_Homo sapiens_hsa052060.73889407
64HIF-1 signaling pathway_Homo sapiens_hsa040660.70818317
65Insulin resistance_Homo sapiens_hsa049310.69106865
66Proteoglycans in cancer_Homo sapiens_hsa052050.65881161
67Platelet activation_Homo sapiens_hsa046110.65431616
68p53 signaling pathway_Homo sapiens_hsa041150.64524612
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61853384
70Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57771324
71Notch signaling pathway_Homo sapiens_hsa043300.55413419
72Systemic lupus erythematosus_Homo sapiens_hsa053220.54443324
73Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53543179
74Prostate cancer_Homo sapiens_hsa052150.52281485
75Focal adhesion_Homo sapiens_hsa045100.50889418
76Lysosome_Homo sapiens_hsa041420.50599297
77Non-small cell lung cancer_Homo sapiens_hsa052230.49046621
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48005867
79Type II diabetes mellitus_Homo sapiens_hsa049300.47967685
80mTOR signaling pathway_Homo sapiens_hsa041500.47751525
81Renal cell carcinoma_Homo sapiens_hsa052110.47614553
82FoxO signaling pathway_Homo sapiens_hsa040680.47445564
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46793234
84Phagosome_Homo sapiens_hsa041450.46126791
85Regulation of actin cytoskeleton_Homo sapiens_hsa048100.45058287
86* MAPK signaling pathway_Homo sapiens_hsa040100.43601819
87Colorectal cancer_Homo sapiens_hsa052100.42831640
88Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.42559417
89Adherens junction_Homo sapiens_hsa045200.37709345
90Fructose and mannose metabolism_Homo sapiens_hsa000510.36887449
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.36718244
92Glycosaminoglycan degradation_Homo sapiens_hsa005310.36496701
93Central carbon metabolism in cancer_Homo sapiens_hsa052300.33737750
94* Pathways in cancer_Homo sapiens_hsa052000.32486846
95GnRH signaling pathway_Homo sapiens_hsa049120.32067017
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.31815442
97Endocytosis_Homo sapiens_hsa041440.31456528
98Sphingolipid metabolism_Homo sapiens_hsa006000.29924822
99Dorso-ventral axis formation_Homo sapiens_hsa043200.29915736
100ErbB signaling pathway_Homo sapiens_hsa040120.29416584
101Other glycan degradation_Homo sapiens_hsa005110.27923840
102Complement and coagulation cascades_Homo sapiens_hsa046100.26588773
103Galactose metabolism_Homo sapiens_hsa000520.26397643
104Endometrial cancer_Homo sapiens_hsa052130.26142688
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.25088458
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.25020753
107Bladder cancer_Homo sapiens_hsa052190.24853640
108PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24754568
109Insulin signaling pathway_Homo sapiens_hsa049100.24635082
110Glioma_Homo sapiens_hsa052140.22431406
111Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.22406053
112Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22174536
113Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21893981

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