NFKBIA

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of cell killing (GO:0031342)4.88573704
2negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.88573704
3NIK/NF-kappaB signaling (GO:0038061)4.82500370
4regulation of interleukin-12 biosynthetic process (GO:0045075)4.45833522
5antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.45460573
6antigen processing and presentation of endogenous antigen (GO:0019883)4.37000645
7neutrophil activation involved in immune response (GO:0002283)4.30144692
8regulation of dendritic cell antigen processing and presentation (GO:0002604)4.22321916
9positive regulation of antigen processing and presentation (GO:0002579)4.09844518
10response to peptidoglycan (GO:0032494)4.09732041
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.99953011
12antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.99953011
13positive regulation of gamma-delta T cell activation (GO:0046645)3.99246406
14myeloid dendritic cell differentiation (GO:0043011)3.90620394
15positive regulation by symbiont of host defense response (GO:0052509)3.82175598
16modulation by symbiont of host defense response (GO:0052031)3.82175598
17modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.82175598
18modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.82175598
19positive regulation by organism of defense response of other organism involved in symbiotic interact3.82175598
20modulation by symbiont of host immune response (GO:0052553)3.82175598
21* response to muramyl dipeptide (GO:0032495)3.75420476
22myeloid dendritic cell activation (GO:0001773)3.74015480
23negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.66222938
24cellular response to interleukin-15 (GO:0071350)3.60590746
25regulation of antigen processing and presentation (GO:0002577)3.60078076
26positive regulation of interleukin-12 production (GO:0032735)3.58764067
27interferon-gamma-mediated signaling pathway (GO:0060333)3.53061337
28positive regulation of heat generation (GO:0031652)3.52646841
29cellular response to type I interferon (GO:0071357)3.51129414
30type I interferon signaling pathway (GO:0060337)3.51129414
31immunoglobulin mediated immune response (GO:0016064)3.50741588
32response to type I interferon (GO:0034340)3.50504548
33regulation of germinal center formation (GO:0002634)3.47021165
34neutrophil activation (GO:0042119)3.46564870
35granulocyte activation (GO:0036230)3.45108441
36positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.44385683
37regulation of fever generation (GO:0031620)3.42004566
38negative regulation of interleukin-1 beta production (GO:0032691)3.39799191
39regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.36397565
40regulation of T-helper 1 cell differentiation (GO:0045625)3.36081290
41response to interleukin-15 (GO:0070672)3.33393328
42positive regulation of chemokine biosynthetic process (GO:0045080)3.31941459
43positive regulation of interferon-alpha production (GO:0032727)3.30841097
44negative regulation of T cell mediated immunity (GO:0002710)3.30612532
45regulation of vitamin metabolic process (GO:0030656)3.28711509
46regulation of T cell mediated cytotoxicity (GO:0001914)3.28226515
47regulation of interferon-alpha production (GO:0032647)3.28154653
48negative regulation of innate immune response (GO:0045824)3.24653040
49positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.21770555
50regulation of chronic inflammatory response (GO:0002676)3.20443210
51positive regulation of defense response to virus by host (GO:0002230)3.19764192
52* lipopolysaccharide-mediated signaling pathway (GO:0031663)3.18904807
53leukocyte aggregation (GO:0070486)3.17923759
54regulation of T-helper cell differentiation (GO:0045622)3.15930252
55negative regulation of cytokine production involved in immune response (GO:0002719)3.15558200
56positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.15039555
57regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.14349324
58T-helper 1 type immune response (GO:0042088)3.12231638
59positive regulation of T-helper cell differentiation (GO:0045624)3.12009433
60T cell differentiation involved in immune response (GO:0002292)3.10903966
61alpha-beta T cell differentiation involved in immune response (GO:0002293)3.10903966
62alpha-beta T cell activation involved in immune response (GO:0002287)3.10903966
63macrophage activation involved in immune response (GO:0002281)3.09562965
64regulation of alpha-beta T cell proliferation (GO:0046640)3.09162998
65regulation of interleukin-12 production (GO:0032655)3.08501379
66interferon-gamma production (GO:0032609)3.07403522
67positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.07217119
68dendritic cell differentiation (GO:0097028)3.06672454
69cellular response to interferon-beta (GO:0035458)3.05114307
70monocyte chemotaxis (GO:0002548)3.04759962
71positive regulation of humoral immune response (GO:0002922)3.01923484
72regulation of immunoglobulin secretion (GO:0051023)3.01427566
73positive regulation of T-helper 1 type immune response (GO:0002827)2.99225538
74regulation of leukocyte mediated cytotoxicity (GO:0001910)2.98893346
75regulation of RIG-I signaling pathway (GO:0039535)2.97474580
76T cell migration (GO:0072678)2.97270668
77positive regulation of T cell mediated cytotoxicity (GO:0001916)2.96185989
78CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.95628982
79T-helper cell differentiation (GO:0042093)2.95628982
80positive regulation of interleukin-17 production (GO:0032740)2.94899310
81positive regulation of interleukin-2 production (GO:0032743)2.94737299
82regulation of defense response to virus by host (GO:0050691)2.94557214
83negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.94498485
84negative regulation of interleukin-6 production (GO:0032715)2.92988039
85positive regulation of natural killer cell differentiation (GO:0032825)2.92557224
86positive regulation of type 2 immune response (GO:0002830)2.92468247
87regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.91354268
88positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.91224284
89respiratory burst (GO:0045730)2.89977325
90regulation of regulatory T cell differentiation (GO:0045589)2.89579294
91germinal center formation (GO:0002467)2.89280012
92regulation of gamma-delta T cell activation (GO:0046643)2.88989529
93negative regulation of interleukin-1 production (GO:0032692)2.88962230
94positive regulation of alpha-beta T cell proliferation (GO:0046641)2.88315637
95JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.88168962
96cellular extravasation (GO:0045123)2.87444040
97negative thymic T cell selection (GO:0045060)2.86186721
98regulation of chemokine biosynthetic process (GO:0045073)2.86119549
99cytokine secretion (GO:0050663)2.85778092
100defense response to protozoan (GO:0042832)2.85177203
101negative regulation of bone resorption (GO:0045779)2.84259565
102response to protozoan (GO:0001562)2.84081968
103positive regulation of interferon-gamma production (GO:0032729)2.83837293
104response to interferon-beta (GO:0035456)2.82650733
105negative regulation of interleukin-12 production (GO:0032695)2.82164234
106T cell activation involved in immune response (GO:0002286)2.82152992
107tumor necrosis factor-mediated signaling pathway (GO:0033209)2.82077537
108regulation of memory T cell differentiation (GO:0043380)2.81638200
109negative regulation of lymphocyte mediated immunity (GO:0002707)2.81283504
110regulation of cell killing (GO:0031341)2.80570964
111regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.80418366
112positive regulation of cellular amide metabolic process (GO:0034250)2.77946230
113regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.77873294
114regulation of natural killer cell mediated immunity (GO:0002715)2.77873294
115microglial cell activation (GO:0001774)2.77594030
116B cell mediated immunity (GO:0019724)2.77504461
117positive regulation of cytokine biosynthetic process (GO:0042108)2.76100270
118myeloid cell activation involved in immune response (GO:0002275)2.76089933
119natural killer cell mediated immunity (GO:0002228)2.75886978
120natural killer cell mediated cytotoxicity (GO:0042267)2.75886978
121negative T cell selection (GO:0043383)2.74397693
122tolerance induction (GO:0002507)2.73014888
123regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.72936700
124superoxide anion generation (GO:0042554)2.71745507
125regulation of B cell receptor signaling pathway (GO:0050855)2.71438627
126leukocyte cell-cell adhesion (GO:0007159)2.70478810
127regulation of heat generation (GO:0031650)2.69899092
128regulation of T-helper 1 type immune response (GO:0002825)2.69709065
129regulation of vitamin D biosynthetic process (GO:0060556)2.68784027
130myeloid leukocyte activation (GO:0002274)2.68238194
131positive regulation of inflammatory response to antigenic stimulus (GO:0002863)2.67369188
132positive regulation of interferon-beta production (GO:0032728)2.65767380
133positive regulation of NF-kappaB import into nucleus (GO:0042346)2.65761087
134lymphocyte chemotaxis (GO:0048247)2.65128912
135regulation of interleukin-1 beta secretion (GO:0050706)2.64953185
136regulation of gamma-delta T cell differentiation (GO:0045586)2.64602417
137positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.63080019
138positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.62658251
139positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.61755818

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.94596383
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.14878565
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.05518566
4IRF8_21731497_ChIP-ChIP_J774_Mouse4.85101088
5BP1_19119308_ChIP-ChIP_Hs578T_Human4.66911072
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.98334764
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.80350678
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.64907970
9SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.51764630
10* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human3.50427692
11IRF8_27001747_Chip-Seq_BMDM_Mouse3.50286173
12EGR1_19374776_ChIP-ChIP_THP-1_Human3.37732128
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.26231620
14NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.93494749
15* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.74708770
16* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.70150950
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.69849993
18* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.62551647
19MYB_21317192_ChIP-Seq_ERMYB_Mouse2.59051243
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.34997163
21* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.34562861
22RUNX_20019798_ChIP-Seq_JUKART_Human2.30449380
23TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.19590915
24* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.99937420
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.99846895
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.91451380
27* MYB_26560356_Chip-Seq_TH2_Human1.90733634
28SMAD_19615063_ChIP-ChIP_OVARY_Human1.80999767
29* MAF_26560356_Chip-Seq_TH1_Human1.78139298
30* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.77678892
31SCL_19346495_ChIP-Seq_HPC-7_Human1.70904778
32* SPI1_23547873_ChIP-Seq_NB4_Human1.64717660
33* VDR_24787735_ChIP-Seq_THP-1_Human1.61293218
34* VDR_24763502_ChIP-Seq_THP-1_Human1.60473239
35GATA2_21666600_ChIP-Seq_HMVEC_Human1.59171573
36MYB_26560356_Chip-Seq_TH1_Human1.58776570
37PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.58343691
38PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.53749820
39* MYC_22102868_ChIP-Seq_BL_Human1.51528922
40PU_27001747_Chip-Seq_BMDM_Mouse1.50861233
41NOTCH1_21737748_ChIP-Seq_TLL_Human1.50348806
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.45487182
43SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.45345218
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.43755740
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43047413
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.40141191
47TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.33215357
48THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.31463439
49CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30987449
50CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.30910283
51SPI1_23127762_ChIP-Seq_K562_Human1.28824822
52* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27007529
53VDR_21846776_ChIP-Seq_THP-1_Human1.25426643
54* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.22419143
55* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.22419143
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.21846747
57GATA3_27048872_Chip-Seq_THYMUS_Human1.21374428
58FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.20226512
59* TCF7_22412390_ChIP-Seq_EML_Mouse1.20155985
60MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.15317009
61UTX_26944678_Chip-Seq_JUKART_Human1.15107226
62VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.13381480
63KDM2B_26808549_Chip-Seq_DND41_Human1.11180192
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.11138730
65TRIM28_21343339_ChIP-Seq_HEK293_Human1.09823114
66CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.09317073
67LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08518517
68* ELK3_25401928_ChIP-Seq_HUVEC_Human1.08377827
69VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.07748714
70GATA1_22025678_ChIP-Seq_K562_Human1.06585790
71CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05977903
72BCL6_27268052_Chip-Seq_Bcells_Human1.05200169
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.04798154
74GATA3_26560356_Chip-Seq_TH2_Human1.04779385
75ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04525300
76P63_26484246_Chip-Seq_KERATINOCYTES_Human1.04432015
77SOX2_20726797_ChIP-Seq_SW620_Human1.02452054
78NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.01945224
79KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01850989
80EGR1_19032775_ChIP-ChIP_M12_Human1.01396900
81STAT1_20625510_ChIP-Seq_HELA_Human1.01345705
82GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00910395
83GATA1_19941827_ChIP-Seq_MEL_Mouse1.00096707
84RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99779238
85JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98592363
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.97365676
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.96795894
88KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96001821
89KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96001821
90KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96001821
91ESR2_21235772_ChIP-Seq_MCF-7_Human0.94869971
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94818685
93SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.94278923
94SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.93828038
95SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93536560
96TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93069528
97* MAF_26560356_Chip-Seq_TH2_Human0.92068316
98GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91976819
99JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91219421
100* CJUN_26792858_Chip-Seq_BT549_Human0.90280404
101TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.89434822
102BCOR_27268052_Chip-Seq_Bcells_Human0.88807472
103CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.88203162
104CDX2_20551321_ChIP-Seq_CACO-2_Human0.86444178
105PU.1_20513432_ChIP-Seq_Bcells_Mouse0.86303551
106ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.85227784
107FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84637531
108HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84006707
109PPARA_22158963_ChIP-Seq_LIVER_Mouse0.83906655
110PPAR_26484153_Chip-Seq_NCI-H1993_Human0.83182561
111PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82867414
112ELF1_17652178_ChIP-ChIP_JURKAT_Human0.82204411
113FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81098422
114GATA2_19941826_ChIP-Seq_K562_Human0.78625876
115ELF1_20517297_ChIP-Seq_JURKAT_Human0.78592115
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77825885
117GATA1_19941826_ChIP-Seq_K562_Human0.76664686
118KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.76415870
119FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.75274990
120KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.74357871
121* CLOCK_20551151_ChIP-Seq_293T_Human0.73474245
122TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.72443440

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.26524888
2MP0003436_decreased_susceptibility_to3.49021361
3MP0000685_abnormal_immune_system3.42714444
4MP0002148_abnormal_hypersensitivity_rea3.37885662
5* MP0009785_altered_susceptibility_to3.36176467
6MP0003724_increased_susceptibility_to3.29734365
7MP0005671_abnormal_response_to3.10312316
8MP0002254_reproductive_system_inflammat3.08586605
9* MP0005000_abnormal_immune_tolerance3.02426720
10MP0005387_immune_system_phenotype3.01559948
11MP0001790_abnormal_immune_system3.01559948
12MP0004510_myositis2.84931477
13MP0003303_peritoneal_inflammation2.77728127
14* MP0001800_abnormal_humoral_immune2.68078836
15* MP0002419_abnormal_innate_immunity2.67110166
16* MP0005025_abnormal_response_to2.65648920
17* MP0002452_abnormal_antigen_presenting2.56788867
18MP0006082_CNS_inflammation2.50839318
19* MP0002723_abnormal_immune_serum2.49592158
20* MP0001819_abnormal_immune_cell2.24521759
21* MP0002420_abnormal_adaptive_immunity2.23156390
22* MP0004947_skin_inflammation2.17390779
23MP0001853_heart_inflammation2.14300259
24MP0002006_tumorigenesis2.12341999
25MP0002138_abnormal_hepatobiliary_system2.11391328
26MP0002405_respiratory_system_inflammati2.07242987
27MP0002166_altered_tumor_susceptibility2.03167944
28MP0010155_abnormal_intestine_physiology1.98507822
29MP0001533_abnormal_skeleton_physiology1.96239435
30MP0001873_stomach_inflammation1.84453088
31MP0003763_abnormal_thymus_physiology1.84071913
32* MP0001845_abnormal_inflammatory_respons1.77796879
33MP0005310_abnormal_salivary_gland1.76958977
34MP0009764_decreased_sensitivity_to1.72147746
35MP0003448_altered_tumor_morphology1.66489278
36* MP0000716_abnormal_immune_system1.61423648
37MP0005464_abnormal_platelet_physiology1.60152874
38MP0009278_abnormal_bone_marrow1.58437004
39MP0003453_abnormal_keratinocyte_physiol1.58432941
40* MP0002398_abnormal_bone_marrow1.54417890
41MP0003300_gastrointestinal_ulcer1.51097986
42MP0009333_abnormal_splenocyte_physiolog1.49313821
43MP0003656_abnormal_erythrocyte_physiolo1.49053763
44MP0001851_eye_inflammation1.43893330
45MP0002277_abnormal_respiratory_mucosa1.42242841
46* MP0008469_abnormal_protein_level1.39503416
47MP0000343_altered_response_to1.39261773
48MP0000858_altered_metastatic_potential1.38228981
49MP0003828_pulmonary_edema1.34265625
50MP0002998_abnormal_bone_remodeling1.30544567
51MP0005397_hematopoietic_system_phenotyp1.29714242
52MP0001545_abnormal_hematopoietic_system1.29714242
53MP0001501_abnormal_sleep_pattern1.29520843
54MP0002139_abnormal_hepatobiliary_system1.27144554
55* MP0002429_abnormal_blood_cell1.25940778
56MP0003195_calcinosis1.25209603
57MP0002933_joint_inflammation1.23207116
58MP0002009_preneoplasia1.22233443
59MP0008004_abnormal_stomach_pH1.21581922
60* MP0000689_abnormal_spleen_morphology1.19916640
61* MP0002722_abnormal_immune_system1.19513244
62MP0005167_abnormal_blood-brain_barrier1.17173392
63MP0001348_abnormal_lacrimal_gland1.14876169
64MP0003075_altered_response_to1.14450057
65MP0000604_amyloidosis1.10535886
66MP0005058_abnormal_lysosome_morphology1.08641211
67MP0005390_skeleton_phenotype1.06936361
68MP0003191_abnormal_cellular_cholesterol1.06595829
69MP0002877_abnormal_melanocyte_morpholog1.05049366
70MP0001346_abnormal_lacrimal_gland1.04358927
71MP0004782_abnormal_surfactant_physiolog1.03991564
72MP0002332_abnormal_exercise_endurance1.00537105
73MP0003172_abnormal_lysosome_physiology1.00422091
74MP0005164_abnormal_response_to0.97962169
75MP0009840_abnormal_foam_cell0.95823302
76MP0001879_abnormal_lymphatic_vessel0.94391506
77MP0005166_decreased_susceptibility_to0.91936966
78MP0004381_abnormal_hair_follicle0.90834707
79MP0010352_gastrointestinal_tract_polyps0.89511622
80MP0003866_abnormal_defecation0.89423139
81MP0000249_abnormal_blood_vessel0.88935194
82MP0009763_increased_sensitivity_to0.85795756
83* MP0000703_abnormal_thymus_morphology0.85715156
84MP0003566_abnormal_cell_adhesion0.85111198
85* MP0001216_abnormal_epidermal_layer0.83993597
86MP0002163_abnormal_gland_morphology0.82695298
87MP0003091_abnormal_cell_migration0.77787958
88MP0010234_abnormal_vibrissa_follicle0.77212509
89MP0005165_increased_susceptibility_to0.75801711
90MP0005023_abnormal_wound_healing0.75253189
91MP0002060_abnormal_skin_morphology0.74957869
92MP0000465_gastrointestinal_hemorrhage0.74929430
93MP0004808_abnormal_hematopoietic_stem0.73880537
94MP0000767_abnormal_smooth_muscle0.73270002
95MP0003045_fibrosis0.73122287
96MP0004883_abnormal_blood_vessel0.70231337
97MP0000490_abnormal_crypts_of0.70108629
98MP0001881_abnormal_mammary_gland0.68961343
99MP0003795_abnormal_bone_structure0.68647188
100MP0002396_abnormal_hematopoietic_system0.67763279
101MP0002136_abnormal_kidney_physiology0.66203716
102MP0003941_abnormal_skin_development0.65407986
103* MP0001191_abnormal_skin_condition0.64881944
104MP0002796_impaired_skin_barrier0.63519433
105MP0005451_abnormal_body_composition0.63417173
106* MP0005076_abnormal_cell_differentiation0.62628188
107MP0000609_abnormal_liver_physiology0.62460585
108MP0003183_abnormal_peptide_metabolism0.62411385
109MP0001663_abnormal_digestive_system0.61569080
110MP0001542_abnormal_bone_strength0.60662048
111MP0006054_spinal_hemorrhage0.60348997
112MP0009765_abnormal_xenobiotic_induced0.59091129
113MP0003646_muscle_fatigue0.57878896
114MP0003690_abnormal_glial_cell0.56844196
115MP0003806_abnormal_nucleotide_metabolis0.53938327
116MP0005535_abnormal_body_temperature0.53144541
117MP0005319_abnormal_enzyme/_coenzyme0.52852558
118MP0005647_abnormal_sex_gland0.52797769
119MP0001919_abnormal_reproductive_system0.51414516
120MP0008874_decreased_physiological_sensi0.48948553
121MP0008875_abnormal_xenobiotic_pharmacok0.46732876

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.15032472
2Recurrent abscess formation (HP:0002722)5.88489672
3Elevated erythrocyte sedimentation rate (HP:0003565)5.53836578
4Recurrent bacterial skin infections (HP:0005406)5.45426477
5Myositis (HP:0100614)5.10103651
6Orchitis (HP:0100796)5.06249868
7Optic neuritis (HP:0100653)5.01745159
8Retrobulbar optic neuritis (HP:0100654)5.01745159
9Mediastinal lymphadenopathy (HP:0100721)4.43595851
10Stomatitis (HP:0010280)4.43399374
11Abnormality of glycolipid metabolism (HP:0010969)4.38215767
12Abnormality of liposaccharide metabolism (HP:0010968)4.38215767
13Abnormality of glycosphingolipid metabolism (HP:0004343)4.38215767
14Recurrent fungal infections (HP:0002841)4.13881427
15Recurrent gram-negative bacterial infections (HP:0005420)4.05874123
16Abnormality of macrophages (HP:0004311)4.02314115
17Recurrent skin infections (HP:0001581)3.80576704
18Vasculitis (HP:0002633)3.77907796
19IgG deficiency (HP:0004315)3.67172279
20Increased IgM level (HP:0003496)3.63985536
21Autoimmune thrombocytopenia (HP:0001973)3.63908113
22Pulmonary infiltrates (HP:0002113)3.50782944
23Recurrent cutaneous fungal infections (HP:0011370)3.48404718
24Chronic mucocutaneous candidiasis (HP:0002728)3.48404718
25Pustule (HP:0200039)3.39742490
26Keratoconjunctivitis (HP:0001096)3.36576027
27Recurrent viral infections (HP:0004429)3.32213597
28Chronic otitis media (HP:0000389)3.29814299
29Systemic lupus erythematosus (HP:0002725)3.29454318
30Gingivitis (HP:0000230)3.28139430
31Keratoconjunctivitis sicca (HP:0001097)3.19441854
32Dysostosis multiplex (HP:0000943)3.18261389
33Colitis (HP:0002583)3.06428139
34Chronic obstructive pulmonary disease (HP:0006510)3.03095887
35Obstructive lung disease (HP:0006536)3.03095887
36Leukocytosis (HP:0001974)3.02919048
37Prostate neoplasm (HP:0100787)3.00016407
38Interstitial pulmonary disease (HP:0006530)2.99950512
39Hematochezia (HP:0002573)2.98015365
40Thick nail (HP:0001805)2.96956477
41Arterial thrombosis (HP:0004420)2.94974811
42Periodontitis (HP:0000704)2.85399391
43Meningitis (HP:0001287)2.83810070
44Hemoptysis (HP:0002105)2.82575388
45Gastrointestinal infarctions (HP:0005244)2.82498519
46Increased IgE level (HP:0003212)2.82019750
47Abnormal delayed hypersensitivity skin test (HP:0002963)2.80007775
48Cellulitis (HP:0100658)2.79128132
49Eosinophilia (HP:0001880)2.77630499
50Inflammation of the large intestine (HP:0002037)2.77622206
51Hypergammaglobulinemia (HP:0010702)2.77452709
52Autoimmune hemolytic anemia (HP:0001890)2.73659407
53Vacuolated lymphocytes (HP:0001922)2.73182574
54Abnormality of the nasal mucosa (HP:0000433)2.72789465
55Nasal polyposis (HP:0100582)2.72065478
56Abnormality of B cell number (HP:0010975)2.68841113
57Abnormality of T cell number (HP:0011839)2.65279359
58Increased serum ferritin (HP:0003281)2.62436274
59Loss of speech (HP:0002371)2.61803421
60Urticaria (HP:0001025)2.59902732
61Polyneuropathy (HP:0001271)2.56405041
62Recurrent bronchitis (HP:0002837)2.54614832
63Gastrointestinal inflammation (HP:0004386)2.53307051
64Spontaneous hematomas (HP:0007420)2.51612708
65Premature loss of primary teeth (HP:0006323)2.48791803
66Myocardial infarction (HP:0001658)2.45968785
67Glomerulopathy (HP:0100820)2.41949557
68Granulocytopenia (HP:0001913)2.41161175
69Gangrene (HP:0100758)2.40696460
70Basal ganglia calcification (HP:0002135)2.40123820
71Tetraparesis (HP:0002273)2.39823745
72Abnormality of eosinophils (HP:0001879)2.39314856
73Pulmonary embolism (HP:0002204)2.38163181
74Vertigo (HP:0002321)2.36376641
75Recurrent pneumonia (HP:0006532)2.35488728
76B lymphocytopenia (HP:0010976)2.35337648
77Neoplasm of the tracheobronchial system (HP:0100552)2.35270145
78Agammaglobulinemia (HP:0004432)2.34002370
79Osteomyelitis (HP:0002754)2.32662322
80Abnormality of polysaccharide metabolism (HP:0011012)2.31523405
81Abnormality of glycosaminoglycan metabolism (HP:0004371)2.31523405
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.31523405
83Keratitis (HP:0000491)2.26297034
84Abnormality of T cell physiology (HP:0011840)2.26244082
85Increased neuronal autofluorescent lipopigment (HP:0002074)2.25499763
86Abnormality of T cells (HP:0002843)2.23964157
87Glomerulonephritis (HP:0000099)2.23851658
88Panhypogammaglobulinemia (HP:0003139)2.22741174
89Episodic fever (HP:0001954)2.21228692
90Petechiae (HP:0000967)2.20081976
91Axonal loss (HP:0003447)2.19334422
92Increased cerebral lipofuscin (HP:0011813)2.19306629
93Abnormality of iron homeostasis (HP:0011031)2.18800985
94T lymphocytopenia (HP:0005403)2.18709866
95Gingival bleeding (HP:0000225)2.18589224
96Parakeratosis (HP:0001036)2.17909766
97Urinary glycosaminoglycan excretion (HP:0003541)2.15563944
98Mucopolysacchariduria (HP:0008155)2.15563944
99Stomach cancer (HP:0012126)2.14945831
100Emphysema (HP:0002097)2.14517988
101Skin ulcer (HP:0200042)2.14133059
102Thyroiditis (HP:0100646)2.13523316
103Amyloidosis (HP:0011034)2.10824375
104Osteolytic defects of the hand bones (HP:0009699)2.10558492
105Osteolytic defects of the phalanges of the hand (HP:0009771)2.10558492
106Recurrent lower respiratory tract infections (HP:0002783)2.10014777
107Abnormality of the prostate (HP:0008775)2.09596687
108IgA deficiency (HP:0002720)2.09017938
109Abnormality of the pericardium (HP:0001697)2.08870132
110Severe combined immunodeficiency (HP:0004430)2.08855085
111Pulmonary fibrosis (HP:0002206)2.08308989
112Encephalitis (HP:0002383)2.07615531
113Chronic diarrhea (HP:0002028)2.06781297
114Restrictive lung disease (HP:0002091)2.06692554
115Gastrointestinal stroma tumor (HP:0100723)2.06188874
116Joint swelling (HP:0001386)2.05789177
117Thrombocytosis (HP:0001894)2.04920138
118Abnormality of cells of the lymphoid lineage (HP:0012140)2.04319813
119Vertebral compression fractures (HP:0002953)2.04005700
120Chest pain (HP:0100749)2.02226777
121Alveolar cell carcinoma (HP:0006519)2.02063820
122Anorexia (HP:0002039)1.99344232
123Abnormality of the endocardium (HP:0004306)1.98485370
124Arthralgia (HP:0002829)1.97089714
125Sepsis (HP:0100806)1.95739092
126Combined immunodeficiency (HP:0005387)1.93815007
127Lymphopenia (HP:0001888)1.92669376
128Abnormality of the pleura (HP:0002103)1.91941007

Predicted kinase interactions (KEA)

RankGene SetZ-score
1* MAP3K144.30632375
2TYK23.49538740
3IRAK33.30101095
4TXK2.98144494
5IRAK42.97665100
6* IKBKB2.94509144
7* TBK12.91419989
8JAK32.81876693
9MAP4K12.65927531
10* IKBKE2.41868829
11RIPK42.41314644
12TGFBR22.13807099
13PIM22.12058187
14JAK12.09232212
15BLK2.06868752
16* CHUK2.02113791
17EPHB11.92185438
18MST41.87698143
19MAP3K131.75425654
20KIT1.73231576
21ERN11.68209151
22TAOK21.63550781
23TESK21.59947721
24ZAP701.52754183
25FGFR41.52533129
26BMPR21.49656441
27MAP3K31.48951178
28EPHA31.48401400
29CSK1.46982645
30TEC1.43601340
31TLK11.43145876
32PRPF4B1.42055080
33STK101.41352284
34PIM11.40031721
35BTK1.34467612
36NLK1.32632260
37ITK1.31902893
38MAPK151.27705240
39FGFR31.24748595
40SYK1.23663458
41RPS6KA41.22297222
42HCK1.21905192
43JAK21.12781700
44ADRBK21.05489402
45* LCK1.04550963
46MAP3K101.03768760
47TAOK31.02019643
48TAOK11.01312041
49CSF1R0.96981206
50IRAK10.95859464
51RIPK10.95689819
52KDR0.94682713
53MAP2K30.90216675
54LYN0.89860303
55MAP2K20.89082370
56GRK70.84765510
57NME20.81360728
58NEK90.78463351
59DDR20.78370188
60BMX0.77735737
61PTK60.77421631
62MAPKAPK20.76543019
63CLK10.71289595
64TGFBR10.70247826
65TNK20.70097278
66MARK30.69931892
67MST1R0.69385926
68CDC42BPA0.68407492
69TIE10.68267323
70TRPM70.66870360
71PBK0.62750187
72BMPR1B0.60742118
73MOS0.58527060
74SIK30.58434292
75LRRK20.58401341
76PRKCD0.54956329
77RPS6KA50.53026973
78MATK0.51630049
79MAP3K10.51614981
80PDK10.51608255
81MAP3K50.50173035
82MAP3K110.50073525
83FGR0.49606518
84MAP2K60.48417110
85PRKCQ0.48325257
86NUAK10.48228332
87GSK3A0.47360534
88* ABL10.47315859
89RPS6KA60.47128984
90CDK40.46175904
91CAMKK20.46132761
92FES0.45397184
93YES10.44633984
94MAPK110.43951340
95ABL20.43412143
96STK240.42514275
97CDK90.41484817
98CDK60.39951322
99DYRK1B0.39703857
100MAPK70.39057903
101RPS6KA20.37757387
102MAPK40.36968914
103GRK60.34344449
104FLT30.34332457
105NEK60.33164035
106PKN10.32838042
107HIPK20.32768630
108* EGFR0.32572980
109IGF1R0.31102005
110PDGFRB0.30110388
111MAPK30.29388543
112RPS6KL10.28995797
113RPS6KC10.28995797
114MAPKAPK30.28641414
115FYN0.27961573
116PRKG20.27650944
117SIK20.27160449
118MAP2K10.26998731
119PDPK10.26738069
120IRAK20.26127552
121FRK0.25936401
122ARAF0.25707226
123DAPK20.25166535
124* INSR0.24949047
125MAPK120.24310872
126BCKDK0.21039442
127ZAK0.19545303

Predicted pathways (KEGG)

RankGene SetZ-score
1Graft-versus-host disease_Homo sapiens_hsa053323.41981964
2* Leishmaniasis_Homo sapiens_hsa051403.09644794
3Allograft rejection_Homo sapiens_hsa053303.09346843
4* NF-kappa B signaling pathway_Homo sapiens_hsa040643.09136000
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.77269991
6* NOD-like receptor signaling pathway_Homo sapiens_hsa046212.51031834
7* Osteoclast differentiation_Homo sapiens_hsa043802.44226623
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.43824194
9* Toll-like receptor signaling pathway_Homo sapiens_hsa046202.39474295
10Malaria_Homo sapiens_hsa051442.30947263
11Staphylococcus aureus infection_Homo sapiens_hsa051502.29798734
12* TNF signaling pathway_Homo sapiens_hsa046682.23446853
13Pertussis_Homo sapiens_hsa051332.19172413
14* Legionellosis_Homo sapiens_hsa051342.18796490
15* Measles_Homo sapiens_hsa051622.16375017
16Primary immunodeficiency_Homo sapiens_hsa053402.01183699
17* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.00154876
18* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.97566460
19Asthma_Homo sapiens_hsa053101.92438789
20Rheumatoid arthritis_Homo sapiens_hsa053231.87810836
21African trypanosomiasis_Homo sapiens_hsa051431.85435552
22Type I diabetes mellitus_Homo sapiens_hsa049401.84668717
23Antigen processing and presentation_Homo sapiens_hsa046121.80499132
24* Toxoplasmosis_Homo sapiens_hsa051451.79650348
25Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.79323602
26Autoimmune thyroid disease_Homo sapiens_hsa053201.78843466
27Tuberculosis_Homo sapiens_hsa051521.75307635
28Hematopoietic cell lineage_Homo sapiens_hsa046401.71605419
29* Influenza A_Homo sapiens_hsa051641.70193298
30Jak-STAT signaling pathway_Homo sapiens_hsa046301.68457359
31* B cell receptor signaling pathway_Homo sapiens_hsa046621.55672946
32* Herpes simplex infection_Homo sapiens_hsa051681.51376067
33Salmonella infection_Homo sapiens_hsa051321.49862573
34* Apoptosis_Homo sapiens_hsa042101.49701161
35* Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.45284674
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.43836285
37* T cell receptor signaling pathway_Homo sapiens_hsa046601.34393865
38* Chemokine signaling pathway_Homo sapiens_hsa040621.30369283
39AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24998695
40Viral myocarditis_Homo sapiens_hsa054161.13599271
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.10587990
42* Hepatitis C_Homo sapiens_hsa051601.05354187
43* Hepatitis B_Homo sapiens_hsa051611.04300689
44* Shigellosis_Homo sapiens_hsa051311.03561683
45Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.99710716
46Acute myeloid leukemia_Homo sapiens_hsa052210.94364866
47Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.92976079
48Lysosome_Homo sapiens_hsa041420.89982024
49Phagosome_Homo sapiens_hsa041450.87158618
50Prolactin signaling pathway_Homo sapiens_hsa049170.86568534
51Amoebiasis_Homo sapiens_hsa051460.86546958
52Transcriptional misregulation in cancer_Homo sapiens_hsa052020.80086843
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79363265
54Other glycan degradation_Homo sapiens_hsa005110.76707587
55Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76270935
56Glycosaminoglycan degradation_Homo sapiens_hsa005310.71646481
57Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68209148
58* Epstein-Barr virus infection_Homo sapiens_hsa051690.67941448
59Pancreatic cancer_Homo sapiens_hsa052120.62953603
60* Small cell lung cancer_Homo sapiens_hsa052220.60656514
61Platelet activation_Homo sapiens_hsa046110.59847073
62* Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59072106
63p53 signaling pathway_Homo sapiens_hsa041150.58432263
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.58391317
65* HTLV-I infection_Homo sapiens_hsa051660.57001840
66* Chronic myeloid leukemia_Homo sapiens_hsa052200.56346876
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.54795019
68Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.54633644
69Prion diseases_Homo sapiens_hsa050200.53651124
70* Adipocytokine signaling pathway_Homo sapiens_hsa049200.51436871
71SNARE interactions in vesicular transport_Homo sapiens_hsa041300.49465511
72Bladder cancer_Homo sapiens_hsa052190.42056991
73Complement and coagulation cascades_Homo sapiens_hsa046100.41943134
74Systemic lupus erythematosus_Homo sapiens_hsa053220.40733384
75Notch signaling pathway_Homo sapiens_hsa043300.40616646
76* Viral carcinogenesis_Homo sapiens_hsa052030.39803235
77* Neurotrophin signaling pathway_Homo sapiens_hsa047220.38916415
78MAPK signaling pathway_Homo sapiens_hsa040100.38453520
79FoxO signaling pathway_Homo sapiens_hsa040680.38159804
80VEGF signaling pathway_Homo sapiens_hsa043700.37579651
81MicroRNAs in cancer_Homo sapiens_hsa052060.36105108
82Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.35231835
83Sphingolipid signaling pathway_Homo sapiens_hsa040710.34784960
84HIF-1 signaling pathway_Homo sapiens_hsa040660.34543695
85Tryptophan metabolism_Homo sapiens_hsa003800.33482038
86Proteoglycans in cancer_Homo sapiens_hsa052050.32606625
87Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31542106
88Caffeine metabolism_Homo sapiens_hsa002320.30240595
89Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.28871666
90Adherens junction_Homo sapiens_hsa045200.28853157
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.27883601
92Sulfur metabolism_Homo sapiens_hsa009200.26813255
93Sphingolipid metabolism_Homo sapiens_hsa006000.25415963
94alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25081976
95Dorso-ventral axis formation_Homo sapiens_hsa043200.24655421
96Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.24596985
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.24502386
98Arachidonic acid metabolism_Homo sapiens_hsa005900.24356321
99* Pathways in cancer_Homo sapiens_hsa052000.22561398
100Endocytosis_Homo sapiens_hsa041440.22518430
101Type II diabetes mellitus_Homo sapiens_hsa049300.22280743
102* Insulin resistance_Homo sapiens_hsa049310.21452168
103Focal adhesion_Homo sapiens_hsa045100.19150100
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17666783
105Non-small cell lung cancer_Homo sapiens_hsa052230.16718406
106Mineral absorption_Homo sapiens_hsa049780.15758511
107Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.14208402
108ABC transporters_Homo sapiens_hsa020100.12051888
109Ras signaling pathway_Homo sapiens_hsa040140.12036236
110Collecting duct acid secretion_Homo sapiens_hsa049660.11810380
111Circadian rhythm_Homo sapiens_hsa047100.07316590
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.06549026
113Linoleic acid metabolism_Homo sapiens_hsa005910.05488402
114mTOR signaling pathway_Homo sapiens_hsa041500.04176071
115Ovarian steroidogenesis_Homo sapiens_hsa049130.03691417

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