NFKBIB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1NIK/NF-kappaB signaling (GO:0038061)4.42403428
2regulation of T-helper 1 cell differentiation (GO:0045625)4.18111160
3neutrophil activation involved in immune response (GO:0002283)4.01675516
4response to peptidoglycan (GO:0032494)3.79448762
5regulation of vitamin D biosynthetic process (GO:0060556)3.78819220
6immunoglobulin mediated immune response (GO:0016064)3.78100623
7antigen processing and presentation of endogenous antigen (GO:0019883)3.73445223
8response to muramyl dipeptide (GO:0032495)3.68637219
9positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.63767795
10antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.57549306
11antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.57549306
12positive regulation of interferon-alpha production (GO:0032727)3.51540386
13positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.47541158
14regulation of interleukin-12 biosynthetic process (GO:0045075)3.45095454
15natural killer cell mediated immunity (GO:0002228)3.44847650
16natural killer cell mediated cytotoxicity (GO:0042267)3.44847650
17tolerance induction (GO:0002507)3.43152031
18myeloid dendritic cell differentiation (GO:0043011)3.40679490
19regulation of interferon-alpha production (GO:0032647)3.38794664
20cellular response to interferon-beta (GO:0035458)3.36287743
21B cell mediated immunity (GO:0019724)3.35404020
22modulation by symbiont of host immune response (GO:0052553)3.34460750
23positive regulation by symbiont of host defense response (GO:0052509)3.34460750
24modulation by symbiont of host defense response (GO:0052031)3.34460750
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.34460750
26modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.34460750
27positive regulation by organism of defense response of other organism involved in symbiotic interact3.34460750
28positive regulation of humoral immune response (GO:0002922)3.31995608
29negative regulation of cell killing (GO:0031342)3.30923682
30negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.30923682
31cellular response to type I interferon (GO:0071357)3.30099974
32type I interferon signaling pathway (GO:0060337)3.30099974
33positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.27936018
34positive regulation of interleukin-12 production (GO:0032735)3.25454708
35response to type I interferon (GO:0034340)3.25427708
36regulation of RIG-I signaling pathway (GO:0039535)3.22497938
37regulation of dendritic cell antigen processing and presentation (GO:0002604)3.19528767
38positive regulation of gamma-delta T cell activation (GO:0046645)3.18431035
39granulocyte activation (GO:0036230)3.16624349
40DNA deamination (GO:0045006)3.14338567
41positive regulation of chemokine biosynthetic process (GO:0045080)3.13831328
42germinal center formation (GO:0002467)3.12343738
43myeloid dendritic cell activation (GO:0001773)3.10680988
44regulation of interferon-beta biosynthetic process (GO:0045357)3.10460670
45response to interferon-beta (GO:0035456)3.09906404
46positive regulation of antigen processing and presentation (GO:0002579)3.09742434
47positive regulation of alpha-beta T cell proliferation (GO:0046641)3.09692668
48macrophage activation involved in immune response (GO:0002281)3.09168860
49lipopolysaccharide-mediated signaling pathway (GO:0031663)3.06659174
50regulation of alpha-beta T cell proliferation (GO:0046640)3.04738804
51respiratory burst (GO:0045730)2.99704648
52positive regulation of isotype switching (GO:0045830)2.98935807
53positive regulation of T-helper cell differentiation (GO:0045624)2.96865095
54regulation of immunoglobulin secretion (GO:0051023)2.96501496
55regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.96484790
56regulation of chronic inflammatory response (GO:0002676)2.95728507
57regulation of activation of Janus kinase activity (GO:0010533)2.93419116
58neutrophil activation (GO:0042119)2.92808255
59defense response to protozoan (GO:0042832)2.92520123
60leukocyte mediated cytotoxicity (GO:0001909)2.91767099
61cellular response to arsenic-containing substance (GO:0071243)2.91749839
62regulation of vitamin metabolic process (GO:0030656)2.91311130
63regulation of interleukin-12 production (GO:0032655)2.90514913
64negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.90289846
65negative regulation of myeloid cell apoptotic process (GO:0033033)2.87467300
66positive regulation of B cell mediated immunity (GO:0002714)2.87107168
67positive regulation of immunoglobulin mediated immune response (GO:0002891)2.87107168
68positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.85187679
69regulation of T cell mediated cytotoxicity (GO:0001914)2.83854904
70antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.83776842
71regulation of antigen processing and presentation (GO:0002577)2.83663747
72positive regulation of T cell mediated cytotoxicity (GO:0001916)2.83521287
73regulation of chemokine biosynthetic process (GO:0045073)2.82610728
74negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.80575468
75positive regulation of type 2 immune response (GO:0002830)2.79873337
76regulation of T-helper cell differentiation (GO:0045622)2.79660087
77positive regulation of leukocyte apoptotic process (GO:2000108)2.79601280
78positive regulation of NF-kappaB import into nucleus (GO:0042346)2.79491268
79negative regulation of interleukin-1 beta production (GO:0032691)2.79129974
80activation of MAPKKK activity (GO:0000185)2.78872504
81T cell migration (GO:0072678)2.78150449
82positive regulation of interferon-beta production (GO:0032728)2.77904943
83regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.77705266
84positive regulation of interleukin-2 production (GO:0032743)2.77177440
85CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.77010905
86positive regulation of defense response to virus by host (GO:0002230)2.76724334
87interferon-gamma-mediated signaling pathway (GO:0060333)2.76214786
88cellular response to virus (GO:0098586)2.76091669
89negative regulation of interleukin-12 production (GO:0032695)2.76016924
90Arp2/3 complex-mediated actin nucleation (GO:0034314)2.75499923
91antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.75170763
92regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.74352126
93ribosomal small subunit biogenesis (GO:0042274)2.73697802
94antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.73503723
95regulation of type I interferon-mediated signaling pathway (GO:0060338)2.73428135
96negative regulation of cytokine production involved in immune response (GO:0002719)2.72018928
97positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.70957394
98negative regulation of viral genome replication (GO:0045071)2.70481216
99regulation of B cell apoptotic process (GO:0002902)2.70437081
100leukocyte aggregation (GO:0070486)2.69770719
101tumor necrosis factor-mediated signaling pathway (GO:0033209)2.68779675
102positive regulation of cytokine biosynthetic process (GO:0042108)2.67473558
103positive regulation of interleukin-17 production (GO:0032740)2.67427785
104negative regulation of tumor necrosis factor production (GO:0032720)2.66845053
105regulation of gamma-delta T cell activation (GO:0046643)2.66663192
106response to protozoan (GO:0001562)2.65874032
107negative thymic T cell selection (GO:0045060)2.64919611
108regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.64595467
109cellular response to zinc ion (GO:0071294)2.64457814
110hydrogen peroxide biosynthetic process (GO:0050665)2.63662900
111positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.63357604
112positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.63262811
113lymphocyte mediated immunity (GO:0002449)2.63214348
114regulation of apoptotic process involved in morphogenesis (GO:1902337)2.63168403
115regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.62953083
116amino sugar catabolic process (GO:0046348)2.61863409
117dendritic cell differentiation (GO:0097028)2.61296650
118T cell apoptotic process (GO:0070231)2.60698781
119negative regulation of interleukin-6 production (GO:0032715)2.60307165
120regulation of inflammatory response to antigenic stimulus (GO:0002861)2.59650005
121positive regulation of T cell apoptotic process (GO:0070234)2.58754484
122negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.57032904
123regulation of defense response to virus by host (GO:0050691)2.55839003
124regulation of hypersensitivity (GO:0002883)2.55347045
125regulation of fever generation (GO:0031620)2.54398767
126positive regulation of prostaglandin secretion (GO:0032308)2.52546553
127regulation of interleukin-2 biosynthetic process (GO:0045076)2.52258333
128cellular response to nicotine (GO:0071316)2.51789336
129T-helper 1 type immune response (GO:0042088)2.51748341
130regulation of T-helper 1 type immune response (GO:0002825)2.50609557
131positive regulation of lymphocyte apoptotic process (GO:0070230)2.49793905
132monocyte chemotaxis (GO:0002548)2.49569072
133positive regulation of heat generation (GO:0031652)2.48044380
134positive regulation of protein homooligomerization (GO:0032464)2.47675114
135myeloid cell activation involved in immune response (GO:0002275)2.47635188
136negative T cell selection (GO:0043383)2.47610671
137reactive oxygen species biosynthetic process (GO:1903409)2.47342972
138interferon-gamma secretion (GO:0072643)2.46237833
139negative regulation of interleukin-1 production (GO:0032692)2.46023393
140regulation of interferon-beta production (GO:0032648)2.45892720
141positive thymic T cell selection (GO:0045059)2.43599867
142negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.42762634
143negative regulation of innate immune response (GO:0045824)2.42716290
144lymphocyte chemotaxis (GO:0048247)2.41973541
145positive regulation of T-helper 1 type immune response (GO:0002827)2.41593867
146regulation of leukocyte mediated cytotoxicity (GO:0001910)2.38880640
147NAD biosynthetic process (GO:0009435)2.38094239

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human4.26124600
2IRF8_21731497_ChIP-ChIP_J774_Mouse3.91347194
3BP1_19119308_ChIP-ChIP_Hs578T_Human3.59550937
4E2F7_22180533_ChIP-Seq_HELA_Human3.39014536
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.13629189
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.88839172
7EGR1_19374776_ChIP-ChIP_THP-1_Human2.67158562
8SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.52631937
9IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.44494573
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.25565614
11STAT4_19710469_ChIP-ChIP_TH1__Mouse2.22790076
12LXR_22292898_ChIP-Seq_THP-1_Human2.18889785
13* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.11427905
14IRF8_27001747_Chip-Seq_BMDM_Mouse2.07805378
15SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.07709838
16MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.03143567
17GABP_17652178_ChIP-ChIP_JURKAT_Human2.01551744
18JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.98183805
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.96607825
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.91128423
21ELF1_20517297_ChIP-Seq_JURKAT_Human1.88503842
22MYC_22102868_ChIP-Seq_BL_Human1.85915572
23* EST1_17652178_ChIP-ChIP_JURKAT_Human1.85510412
24MYB_21317192_ChIP-Seq_ERMYB_Mouse1.85471472
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.85111669
26VDR_21846776_ChIP-Seq_THP-1_Human1.83626244
27NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.83176204
28SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.81945948
29FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.81699331
30SPI1_23547873_ChIP-Seq_NB4_Human1.81514887
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.81196536
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.80903616
33ETS1_20019798_ChIP-Seq_JURKAT_Human1.78351220
34* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.77840838
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.74465819
36P68_20966046_ChIP-Seq_HELA_Human1.72809449
37BCOR_27268052_Chip-Seq_Bcells_Human1.68179702
38KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.64471408
39TET1_21451524_ChIP-Seq_MESCs_Mouse1.63998809
40VDR_23849224_ChIP-Seq_CD4+_Human1.61721236
41ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.61246871
42STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.60465821
43MAF_26560356_Chip-Seq_TH1_Human1.60399397
44KDM2B_26808549_Chip-Seq_SUP-B15_Human1.59305974
45STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.58326923
46MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56921351
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.56890969
48MYC_19030024_ChIP-ChIP_MESCs_Mouse1.56409123
49NOTCH1_21737748_ChIP-Seq_TLL_Human1.55789301
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51061490
51XRN2_22483619_ChIP-Seq_HELA_Human1.49706349
52TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.49225783
53MYB_26560356_Chip-Seq_TH2_Human1.47568882
54RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.46767566
55STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.45582605
56* HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.45080896
57KDM2B_26808549_Chip-Seq_DND41_Human1.44880818
58SA1_27219007_Chip-Seq_ERYTHROID_Human1.43676780
59DCP1A_22483619_ChIP-Seq_HELA_Human1.41303725
60CTCF_26484167_Chip-Seq_Bcells_Mouse1.41135889
61* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.39970095
62BRD4_27068464_Chip-Seq_AML-cells_Mouse1.37183571
63SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.35923775
64EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.35668965
65* STAT3_1855785_ChIP-Seq_MESCs_Mouse1.34306823
66MYB_26560356_Chip-Seq_TH1_Human1.34279520
67PHF8_20622854_ChIP-Seq_HELA_Human1.34240937
68PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.33679613
69VDR_24763502_ChIP-Seq_THP-1_Human1.32807202
70RUNX1_22412390_ChIP-Seq_EML_Mouse1.32336437
71E2F1_20622854_ChIP-Seq_HELA_Human1.31946232
72MAF_26560356_Chip-Seq_TH2_Human1.31823576
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.31473003
74CTCF_27219007_Chip-Seq_ERYTHROID_Human1.30836665
75YY1_22570637_ChIP-Seq_MALME-3M_Human1.29724810
76TCF7_22412390_ChIP-Seq_EML_Mouse1.29512506
77E2F1_18555785_ChIP-Seq_MESCs_Mouse1.28804787
78RACK7_27058665_Chip-Seq_MCF-7_Human1.27663998
79* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.27415408
80SA1_27219007_Chip-Seq_Bcells_Human1.27250313
81FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.26528288
82NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24686749
83CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.24308552
84FOXP3_21729870_ChIP-Seq_TREG_Human1.23186115
85UTX_26944678_Chip-Seq_JUKART_Human1.23093979
86E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.22888080
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.22802045
88CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.21760835
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.20463045
90SRF_21415370_ChIP-Seq_HL-1_Mouse1.19580818
91GABP_19822575_ChIP-Seq_HepG2_Human1.18500964
92PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18479213
93TFEB_21752829_ChIP-Seq_HELA_Human1.18366754
94SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.17578558
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17304103
96CTCF_20526341_ChIP-Seq_ESCs_Human1.16805008
97NANOG_18555785_ChIP-Seq_MESCs_Mouse1.15732050
98CTCF_21964334_Chip-Seq_Bcells_Human1.15011804
99RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.14623550
100E2F4_17652178_ChIP-ChIP_JURKAT_Human1.12944107
101KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.12512451
102SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12396890
103MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.11707833
104SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10678727
105HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10504643
106STAT1_20625510_ChIP-Seq_HELA_Human1.10255189
107STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.10038229
108CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09701939
109* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.09226631
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08683968
111P300_27268052_Chip-Seq_Bcells_Human1.08397134
112ELK3_25401928_ChIP-Seq_HUVEC_Human1.08307233
113ERG_20887958_ChIP-Seq_HPC-7_Mouse1.06933117
114CTCF_21964334_ChIP-Seq_BJAB-B_Human1.06901544
115GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.06642216
116CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.06485031
117CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.05916427
118FOXM1_23109430_ChIP-Seq_U2OS_Human1.05401579
119NCOR1_26117541_ChIP-Seq_K562_Human1.05068526
120PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05037081
121PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05021865
122CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.04668466
123MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.04110945
124LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04109152
125SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.03566652
126GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03448816
127Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.03367375
128GATA2_22383799_ChIP-Seq_G1ME_Mouse1.02898192
129LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.02085992
130E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.01982577
131CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01478837
132PU.1_20513432_ChIP-Seq_Bcells_Mouse1.01454158
133CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.01128219
134PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99242274
135ELK1_19687146_ChIP-ChIP_HELA_Human0.98091280
136HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.94353242
137FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.93516000
138BCL6_27268052_Chip-Seq_Bcells_Human0.92994523
139TTF2_22483619_ChIP-Seq_HELA_Human0.92749610
140HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.92257530

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.32220863
2* MP0009785_altered_susceptibility_to3.47567484
3MP0000685_abnormal_immune_system3.47081428
4* MP0003436_decreased_susceptibility_to3.27219719
5MP0002148_abnormal_hypersensitivity_rea3.24257183
6* MP0005000_abnormal_immune_tolerance2.95106597
7MP0005671_abnormal_response_to2.93831420
8MP0006082_CNS_inflammation2.85518814
9MP0001790_abnormal_immune_system2.84956157
10MP0005387_immune_system_phenotype2.84956157
11* MP0005025_abnormal_response_to2.71638353
12MP0003303_peritoneal_inflammation2.69473286
13MP0001800_abnormal_humoral_immune2.65055938
14MP0004510_myositis2.53190512
15MP0002452_abnormal_antigen_presenting2.53085136
16* MP0002723_abnormal_immune_serum2.49913356
17MP0009333_abnormal_splenocyte_physiolog2.46562550
18MP0002419_abnormal_innate_immunity2.41939475
19MP0001853_heart_inflammation2.31264698
20MP0001819_abnormal_immune_cell2.24748583
21MP0002420_abnormal_adaptive_immunity2.22520293
22MP0003724_increased_susceptibility_to2.19457844
23MP0003763_abnormal_thymus_physiology2.14321379
24MP0002405_respiratory_system_inflammati2.12619125
25MP0002138_abnormal_hepatobiliary_system2.02815617
26MP0001986_abnormal_taste_sensitivity2.00163272
27MP0002398_abnormal_bone_marrow1.95236741
28MP0000716_abnormal_immune_system1.85791563
29MP0003693_abnormal_embryo_hatching1.83989108
30MP0009840_abnormal_foam_cell1.83151611
31MP0004947_skin_inflammation1.82606704
32MP0002139_abnormal_hepatobiliary_system1.76551498
33* MP0001845_abnormal_inflammatory_respons1.74563238
34MP0008057_abnormal_DNA_replication1.73312953
35MP0010155_abnormal_intestine_physiology1.67749396
36MP0005397_hematopoietic_system_phenotyp1.66612262
37MP0001545_abnormal_hematopoietic_system1.66612262
38MP0001348_abnormal_lacrimal_gland1.66355355
39MP0000689_abnormal_spleen_morphology1.66296730
40MP0002722_abnormal_immune_system1.61315554
41MP0002429_abnormal_blood_cell1.61030580
42MP0003186_abnormal_redox_activity1.57882261
43MP0009764_decreased_sensitivity_to1.56862574
44MP0000858_altered_metastatic_potential1.55105506
45MP0005310_abnormal_salivary_gland1.54032380
46MP0005464_abnormal_platelet_physiology1.53976066
47* MP0008469_abnormal_protein_level1.53276843
48* MP0001533_abnormal_skeleton_physiology1.46784767
49MP0003448_altered_tumor_morphology1.40542185
50MP0010352_gastrointestinal_tract_polyps1.39121619
51MP0003300_gastrointestinal_ulcer1.37350260
52MP0002006_tumorigenesis1.35840433
53MP0003077_abnormal_cell_cycle1.35610053
54MP0005410_abnormal_fertilization1.30684207
55MP0002163_abnormal_gland_morphology1.29229241
56MP0000490_abnormal_crypts_of1.28264172
57MP0009278_abnormal_bone_marrow1.25729352
58MP0005058_abnormal_lysosome_morphology1.22195729
59MP0000703_abnormal_thymus_morphology1.21497046
60MP0008007_abnormal_cellular_replicative1.21374628
61MP0001919_abnormal_reproductive_system1.19520007
62MP0004957_abnormal_blastocyst_morpholog1.17823731
63MP0000343_altered_response_to1.17492198
64MP0010307_abnormal_tumor_latency1.15207371
65MP0002277_abnormal_respiratory_mucosa1.14497992
66MP0003806_abnormal_nucleotide_metabolis1.11895353
67MP0002396_abnormal_hematopoietic_system1.11844583
68MP0005076_abnormal_cell_differentiation1.08738014
69MP0002166_altered_tumor_susceptibility1.08661836
70MP0003111_abnormal_nucleus_morphology1.08227188
71MP0002254_reproductive_system_inflammat1.07664152
72MP0003878_abnormal_ear_physiology1.06084873
73MP0005377_hearing/vestibular/ear_phenot1.06084873
74MP0002019_abnormal_tumor_incidence1.04385143
75MP0001873_stomach_inflammation0.98939117
76MP0008058_abnormal_DNA_repair0.98216953
77MP0009763_increased_sensitivity_to0.97115530
78MP0003866_abnormal_defecation0.96930636
79MP0001663_abnormal_digestive_system0.96884281
80MP0010094_abnormal_chromosome_stability0.96746819
81MP0004185_abnormal_adipocyte_glucose0.96632587
82MP0003191_abnormal_cellular_cholesterol0.96462581
83MP0005167_abnormal_blood-brain_barrier0.92385266
84MP0002693_abnormal_pancreas_physiology0.89210146
85MP0000678_abnormal_parathyroid_gland0.88542681
86MP0000313_abnormal_cell_death0.86652754
87MP0004808_abnormal_hematopoietic_stem0.86555089
88MP0005647_abnormal_sex_gland0.86207570
89MP0001727_abnormal_embryo_implantation0.86069835
90MP0003656_abnormal_erythrocyte_physiolo0.85656156
91MP0003453_abnormal_keratinocyte_physiol0.84929124
92MP0002132_abnormal_respiratory_system0.82476770
93MP0002933_joint_inflammation0.80822885
94MP0003646_muscle_fatigue0.79905764
95MP0005023_abnormal_wound_healing0.78057050
96MP0005083_abnormal_biliary_tract0.76758687
97MP0000350_abnormal_cell_proliferation0.76067215
98MP0001764_abnormal_homeostasis0.75269999
99MP0003075_altered_response_to0.75195981
100MP0009765_abnormal_xenobiotic_induced0.67638920
101MP0006036_abnormal_mitochondrial_physio0.67517125
102MP0000609_abnormal_liver_physiology0.66940132
103MP0008961_abnormal_basal_metabolism0.66926316
104MP0005451_abnormal_body_composition0.66630130
105MP0001346_abnormal_lacrimal_gland0.66058657
106MP0000598_abnormal_liver_morphology0.64739025
107MP0003172_abnormal_lysosome_physiology0.64364493
108MP0002998_abnormal_bone_remodeling0.64153542
109MP0005379_endocrine/exocrine_gland_phen0.63646158
110MP0000604_amyloidosis0.63423210
111MP0005319_abnormal_enzyme/_coenzyme0.62943534
112* MP0005390_skeleton_phenotype0.62924183
113MP0008932_abnormal_embryonic_tissue0.62624102
114MP0004782_abnormal_surfactant_physiolog0.62447450
115MP0005365_abnormal_bile_salt0.61830727
116MP0008873_increased_physiological_sensi0.61620738
117MP0008874_decreased_physiological_sensi0.60767163
118MP0003195_calcinosis0.60476801
119MP0002136_abnormal_kidney_physiology0.59948483
120MP0002332_abnormal_exercise_endurance0.59814316
121MP0001851_eye_inflammation0.59542583
122MP0005166_decreased_susceptibility_to0.59251169
123MP0005381_digestive/alimentary_phenotyp0.58565736
124MP0003718_maternal_effect0.58463797
125MP0008260_abnormal_autophagy0.56534503

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.99205153
2Elevated erythrocyte sedimentation rate (HP:0003565)5.54462266
3Recurrent abscess formation (HP:0002722)5.26162008
4Recurrent bacterial skin infections (HP:0005406)4.96667118
5Increased IgM level (HP:0003496)4.81348460
6Abnormality of liposaccharide metabolism (HP:0010968)4.73100925
7Abnormality of glycosphingolipid metabolism (HP:0004343)4.73100925
8Abnormality of glycolipid metabolism (HP:0010969)4.73100925
9Abnormality of macrophages (HP:0004311)4.44003670
10Mediastinal lymphadenopathy (HP:0100721)4.33961057
11Autoimmune thrombocytopenia (HP:0001973)4.28279822
12Recurrent gram-negative bacterial infections (HP:0005420)4.22595237
13Stomatitis (HP:0010280)4.09788037
14Increased cerebral lipofuscin (HP:0011813)3.95214138
15Myositis (HP:0100614)3.91798275
16Recurrent fungal infections (HP:0002841)3.75857361
17Orchitis (HP:0100796)3.60568362
18Vasculitis (HP:0002633)3.51551095
19Retrobulbar optic neuritis (HP:0100654)3.43082553
20Optic neuritis (HP:0100653)3.43082553
21Nasal polyposis (HP:0100582)3.33440979
22Recurrent skin infections (HP:0001581)3.31064852
23Obstructive lung disease (HP:0006536)3.16725632
24Chronic obstructive pulmonary disease (HP:0006510)3.16725632
25Recurrent viral infections (HP:0004429)3.13783751
26Hypergammaglobulinemia (HP:0010702)3.01350992
27Chronic otitis media (HP:0000389)2.95181338
28Petechiae (HP:0000967)2.91976396
29Gingivitis (HP:0000230)2.91326231
30Interstitial pulmonary disease (HP:0006530)2.85083228
31Abnormality of T cell number (HP:0011839)2.83805721
32Basal ganglia calcification (HP:0002135)2.81484945
33Gastrointestinal infarctions (HP:0005244)2.80674920
34Urticaria (HP:0001025)2.80126483
35Abnormality of the nasal mucosa (HP:0000433)2.77554971
36Poor head control (HP:0002421)2.77484506
37Leukocytosis (HP:0001974)2.75995836
38Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.73983554
39Abnormality of T cells (HP:0002843)2.73052105
40Abnormality of T cell physiology (HP:0011840)2.70551928
41Pustule (HP:0200039)2.68679887
42Vacuolated lymphocytes (HP:0001922)2.68582756
43Recurrent bronchitis (HP:0002837)2.66589823
44Systemic lupus erythematosus (HP:0002725)2.66369198
45Dysostosis multiplex (HP:0000943)2.65565580
46Thrombocytosis (HP:0001894)2.63738646
47Granulocytopenia (HP:0001913)2.60865318
48Microretrognathia (HP:0000308)2.59464006
49Eosinophilia (HP:0001880)2.58791094
50Pulmonary infiltrates (HP:0002113)2.58347385
51Chronic mucocutaneous candidiasis (HP:0002728)2.56910607
52Recurrent cutaneous fungal infections (HP:0011370)2.56910607
53Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.56560805
54Combined immunodeficiency (HP:0005387)2.55531882
55Cellulitis (HP:0100658)2.54027965
56Multiple enchondromatosis (HP:0005701)2.51052848
57Loss of speech (HP:0002371)2.46525835
58Prolonged neonatal jaundice (HP:0006579)2.46269294
59Tetraparesis (HP:0002273)2.45568983
60Increased serum ferritin (HP:0003281)2.40920033
61Cleft eyelid (HP:0000625)2.40809046
62Anorexia (HP:0002039)2.40063686
63Abnormality of transition element cation homeostasis (HP:0011030)2.38876724
64Joint swelling (HP:0001386)2.38006784
65Parakeratosis (HP:0001036)2.37698238
66Severe visual impairment (HP:0001141)2.37173941
67T lymphocytopenia (HP:0005403)2.37124557
68Meningitis (HP:0001287)2.36962705
69Abnormality of cells of the lymphoid lineage (HP:0012140)2.36410577
70Nausea (HP:0002018)2.34637786
71Mesangial abnormality (HP:0001966)2.34501499
72Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.32648826
73Abnormality of eosinophils (HP:0001879)2.28987811
74Abnormal delayed hypersensitivity skin test (HP:0002963)2.26098671
75IgG deficiency (HP:0004315)2.22514817
76Severe combined immunodeficiency (HP:0004430)2.22478013
77Autoimmune hemolytic anemia (HP:0001890)2.21671277
78Vertebral compression fractures (HP:0002953)2.20641457
79Degeneration of anterior horn cells (HP:0002398)2.18147866
80Abnormality of the anterior horn cell (HP:0006802)2.18147866
81Hemoptysis (HP:0002105)2.15387617
82Recurrent pneumonia (HP:0006532)2.14435357
83Abnormal number of erythroid precursors (HP:0012131)2.12476762
84Lymphopenia (HP:0001888)2.12189515
85Hypertensive crisis (HP:0100735)2.11552061
86Agnosia (HP:0010524)2.10888406
87Purpura (HP:0000979)2.08756695
88Abnormality of cells of the erythroid lineage (HP:0012130)2.08314683
89Abnormality of polysaccharide metabolism (HP:0011012)2.07689728
90Abnormality of glycosaminoglycan metabolism (HP:0004371)2.07689728
91Abnormality of mucopolysaccharide metabolism (HP:0011020)2.07689728
92Hepatosplenomegaly (HP:0001433)2.05522403
93Porencephaly (HP:0002132)2.04164201
94Skin ulcer (HP:0200042)2.02114849
95IgA deficiency (HP:0002720)2.01464177
96Arterial thrombosis (HP:0004420)2.01427804
97Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.01367884
98Lymphoma (HP:0002665)2.01078965
99Generalized aminoaciduria (HP:0002909)1.99731914
100Keratoconjunctivitis sicca (HP:0001097)1.99567928
101Gingival bleeding (HP:0000225)1.99245994
102Osteomyelitis (HP:0002754)1.98900513
103Cutaneous photosensitivity (HP:0000992)1.98396928
104Progressive neurologic deterioration (HP:0002344)1.97842642
105Recurrent lower respiratory tract infections (HP:0002783)1.96238576
106Periodontitis (HP:0000704)1.94933295
107Pallor (HP:0000980)1.94067616
108Exertional dyspnea (HP:0002875)1.93864463
109Albinism (HP:0001022)1.93773646
110Neutropenia (HP:0001875)1.92976796
111IgM deficiency (HP:0002850)1.92387740
112Increased IgE level (HP:0003212)1.92356648
113Acne (HP:0001061)1.91106101
114Increased neuronal autofluorescent lipopigment (HP:0002074)1.90522805
115Gastrointestinal stroma tumor (HP:0100723)1.89406837
116Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89102917
117Abnormality of iron homeostasis (HP:0011031)1.88943765
118Neoplasm of head and neck (HP:0012288)1.88117743
119Esophageal neoplasm (HP:0100751)1.88117743
120Hypochromic anemia (HP:0001931)1.87447166
121Keratoconjunctivitis (HP:0001096)1.86240512
122Emphysema (HP:0002097)1.85938262
123Gangrene (HP:0100758)1.84248995
124Mutism (HP:0002300)1.82722348
125Arthralgia (HP:0002829)1.82024863
126Abnormality of lateral ventricle (HP:0030047)1.81838471
127Encephalitis (HP:0002383)1.81596053
128Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.81350106
129Gastrointestinal inflammation (HP:0004386)1.80906737
130Panhypogammaglobulinemia (HP:0003139)1.80203175
131Breast hypoplasia (HP:0003187)1.79475689
132Axonal loss (HP:0003447)1.77424918
133Increased muscle lipid content (HP:0009058)1.76813874
134Birth length less than 3rd percentile (HP:0003561)1.75933237
135Flat occiput (HP:0005469)1.75656305
136Renal Fanconi syndrome (HP:0001994)1.72880886
137Colitis (HP:0002583)1.68709072
138Urinary glycosaminoglycan excretion (HP:0003541)1.68347165
139Mucopolysacchariduria (HP:0008155)1.68347165
140Increased intramyocellular lipid droplets (HP:0012240)1.67211051

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.78202016
2TBK13.56164695
3PIM23.33219277
4MAP4K13.29777326
5IRAK33.01013679
6SMG12.97405865
7IRAK42.96753834
8TYK22.93820655
9IKBKE2.63668224
10* IKBKB2.61490909
11NME22.48741195
12BLK2.41924478
13ERN12.35933857
14JAK32.28699096
15TXK2.25869496
16MAP3K112.12188720
17VRK22.04040484
18EIF2AK12.00980218
19PBK1.91814539
20RPS6KA41.89428944
21ZAP701.88576435
22BUB11.79483049
23TESK21.79381013
24TESK11.76343304
25MST41.67273884
26* CHUK1.66456073
27STK101.53919214
28MAP2K31.48865488
29PIM11.47593506
30ADRBK21.38552638
31KDR1.34575051
32EPHB11.26151637
33JAK11.25099396
34RIPK41.23826201
35MAP2K21.23776413
36GRK71.20167180
37BTK1.17102053
38IRAK11.14293537
39SYK1.14258673
40KIT1.09127699
41DDR21.08074740
42PLK41.06719917
43MAP3K101.01544344
44MAP3K130.99059532
45ARAF0.96309279
46SIK20.95581763
47FGFR40.95366038
48LCK0.94198958
49MAP3K10.93918654
50RPS6KA60.93264611
51HIPK20.92809121
52STK40.92114473
53CSK0.91761341
54MAP3K30.91468346
55SIK10.91455115
56GRK60.90749146
57SIK30.88470572
58MAP3K50.85587838
59RPS6KC10.85565288
60RPS6KL10.85565288
61EIF2AK20.85537628
62EIF2AK30.84989005
63CDC42BPA0.84803329
64MAP3K80.84437470
65MARK30.81528860
66LYN0.77482615
67CSF1R0.76758772
68TAOK20.76757840
69BMPR20.75193992
70TEC0.72888888
71MAPK110.72553692
72TLK10.70355350
73BMX0.70008399
74HCK0.69764871
75NEK90.68733110
76PDPK10.67785715
77WEE10.66588426
78NLK0.66435352
79IRAK20.65539074
80BRAF0.64093951
81LRRK20.63146989
82MAPKAPK20.62938237
83NEK20.62732504
84MAPKAPK30.62461498
85JAK20.61830966
86TSSK60.61562709
87ITK0.61072170
88TRIB30.60052662
89ICK0.56615881
90TAF10.56584857
91RPS6KA50.56494625
92PAK40.55975954
93EPHA30.55843962
94RPS6KA20.55548756
95CDK120.55492049
96CDK40.54460343
97BCKDK0.54262892
98FGR0.53783107
99TNK20.53154522
100VRK10.52838475
101CAMK1D0.52418050
102PAK10.52072777
103TAOK10.51482098
104FLT30.50059245
105PDK10.49880648
106PRKCI0.49699264
107TAOK30.49530245
108CDK70.48844659
109PRKCD0.46996721
110CHEK20.46360965
111* ABL20.45916211
112MAP3K90.45155372
113AURKA0.45087429
114RAF10.44421493
115MOS0.43456431
116FES0.43033841
117MAPK40.40501913
118NME10.39890733
119ZAK0.39857794
120ATR0.38604608
121ACVR1B0.38459799
122DAPK10.37385703
123* RPS6KA10.36969691
124MAP2K60.36177115
125ALK0.34468999
126MELK0.33974954
127STK160.32826061
128PLK10.32422261
129DAPK30.32038520
130DYRK30.31490237
131ABL10.30438589
132MATK0.29873474
133EGFR0.28372015
134PRPF4B0.28369590
135SCYL20.26509563

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.49720421
2Graft-versus-host disease_Homo sapiens_hsa053323.20994614
3Proteasome_Homo sapiens_hsa030502.93535718
4* Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.85271825
5NF-kappa B signaling pathway_Homo sapiens_hsa040642.57912270
6* Leishmaniasis_Homo sapiens_hsa051402.49002174
7Legionellosis_Homo sapiens_hsa051342.35202443
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.14117829
9Toll-like receptor signaling pathway_Homo sapiens_hsa046202.08631056
10Type I diabetes mellitus_Homo sapiens_hsa049402.08073367
11* Measles_Homo sapiens_hsa051621.98363294
12DNA replication_Homo sapiens_hsa030301.97067698
13Asthma_Homo sapiens_hsa053101.92315631
14Ribosome_Homo sapiens_hsa030101.90967697
15* NOD-like receptor signaling pathway_Homo sapiens_hsa046211.86829737
16* RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.85537429
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.84354862
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.81317672
19Autoimmune thyroid disease_Homo sapiens_hsa053201.77978834
20Antigen processing and presentation_Homo sapiens_hsa046121.69841671
21* Herpes simplex infection_Homo sapiens_hsa051681.67472707
22Primary immunodeficiency_Homo sapiens_hsa053401.67269422
23RNA polymerase_Homo sapiens_hsa030201.58420350
24Osteoclast differentiation_Homo sapiens_hsa043801.57395192
25TNF signaling pathway_Homo sapiens_hsa046681.56771855
26* Influenza A_Homo sapiens_hsa051641.52640571
27Base excision repair_Homo sapiens_hsa034101.51496214
28Bladder cancer_Homo sapiens_hsa052191.51313539
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.49845922
30Pertussis_Homo sapiens_hsa051331.49459626
31Rheumatoid arthritis_Homo sapiens_hsa053231.46995806
32Malaria_Homo sapiens_hsa051441.46391953
33Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.42707747
34Apoptosis_Homo sapiens_hsa042101.39236363
35Staphylococcus aureus infection_Homo sapiens_hsa051501.34207450
36Tuberculosis_Homo sapiens_hsa051521.30196958
37* Epstein-Barr virus infection_Homo sapiens_hsa051691.30042606
38Mismatch repair_Homo sapiens_hsa034301.28658546
39Pyrimidine metabolism_Homo sapiens_hsa002401.26977915
40Sulfur metabolism_Homo sapiens_hsa009201.25475260
41* Shigellosis_Homo sapiens_hsa051311.22913924
42One carbon pool by folate_Homo sapiens_hsa006701.21514577
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.21061769
44Homologous recombination_Homo sapiens_hsa034401.18613734
45Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17414668
46* Toxoplasmosis_Homo sapiens_hsa051451.14842583
47Oxidative phosphorylation_Homo sapiens_hsa001901.12572820
48Spliceosome_Homo sapiens_hsa030401.11054575
49Viral myocarditis_Homo sapiens_hsa054161.08559072
50African trypanosomiasis_Homo sapiens_hsa051431.07627103
51* B cell receptor signaling pathway_Homo sapiens_hsa046621.05231387
52Salmonella infection_Homo sapiens_hsa051321.04489020
53Hematopoietic cell lineage_Homo sapiens_hsa046401.01029963
54Collecting duct acid secretion_Homo sapiens_hsa049660.99286368
55Folate biosynthesis_Homo sapiens_hsa007900.99050643
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97048885
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.96910184
58Sulfur relay system_Homo sapiens_hsa041220.96477318
59p53 signaling pathway_Homo sapiens_hsa041150.96357912
60Acute myeloid leukemia_Homo sapiens_hsa052210.95703151
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.95168423
62* T cell receptor signaling pathway_Homo sapiens_hsa046600.93812696
63Hepatitis B_Homo sapiens_hsa051610.92579202
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91792338
65RNA transport_Homo sapiens_hsa030130.91048678
66Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.86950961
67Nucleotide excision repair_Homo sapiens_hsa034200.86307623
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84909439
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.81500978
70Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.79841421
71VEGF signaling pathway_Homo sapiens_hsa043700.76606601
72Hepatitis C_Homo sapiens_hsa051600.76004004
73Pentose phosphate pathway_Homo sapiens_hsa000300.75017382
74* Adipocytokine signaling pathway_Homo sapiens_hsa049200.72249074
75* Chemokine signaling pathway_Homo sapiens_hsa040620.70759249
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70548577
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.70280354
78Lysosome_Homo sapiens_hsa041420.69298267
79Viral carcinogenesis_Homo sapiens_hsa052030.65751909
80HTLV-I infection_Homo sapiens_hsa051660.62842840
81Phagosome_Homo sapiens_hsa041450.62567484
82Other glycan degradation_Homo sapiens_hsa005110.61111455
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59285672
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58435407
85Parkinsons disease_Homo sapiens_hsa050120.57712270
86Systemic lupus erythematosus_Homo sapiens_hsa053220.56600278
87Prolactin signaling pathway_Homo sapiens_hsa049170.51249704
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.48536376
89RNA degradation_Homo sapiens_hsa030180.48139908
90Fructose and mannose metabolism_Homo sapiens_hsa000510.47350548
91Glycosaminoglycan degradation_Homo sapiens_hsa005310.46929306
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.46022884
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.45458022
94Cell cycle_Homo sapiens_hsa041100.44932648
95Small cell lung cancer_Homo sapiens_hsa052220.43039409
96Chronic myeloid leukemia_Homo sapiens_hsa052200.42938260
97Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.42903181
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41587256
99Selenocompound metabolism_Homo sapiens_hsa004500.40587526
100Prion diseases_Homo sapiens_hsa050200.38319381
101Galactose metabolism_Homo sapiens_hsa000520.38014674
102Basal transcription factors_Homo sapiens_hsa030220.37244737
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.35673939
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.35359946
105Sphingolipid metabolism_Homo sapiens_hsa006000.34706862
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.34282642
107HIF-1 signaling pathway_Homo sapiens_hsa040660.34234390
108MAPK signaling pathway_Homo sapiens_hsa040100.32892194
109Fanconi anemia pathway_Homo sapiens_hsa034600.32513315
110Cysteine and methionine metabolism_Homo sapiens_hsa002700.32296739
111Protein export_Homo sapiens_hsa030600.31254447
112Leukocyte transendothelial migration_Homo sapiens_hsa046700.30832361
113Huntingtons disease_Homo sapiens_hsa050160.29984869
114Purine metabolism_Homo sapiens_hsa002300.29737236
115Glutathione metabolism_Homo sapiens_hsa004800.27975585
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27669171
117Notch signaling pathway_Homo sapiens_hsa043300.26235903
118Phenylalanine metabolism_Homo sapiens_hsa003600.25367002
119alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24432914
120Alzheimers disease_Homo sapiens_hsa050100.24068148
121Endocytosis_Homo sapiens_hsa041440.23585987
122Sphingolipid signaling pathway_Homo sapiens_hsa040710.22953072
123Non-small cell lung cancer_Homo sapiens_hsa052230.20302501
124SNARE interactions in vesicular transport_Homo sapiens_hsa041300.20283369

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