NFKBID

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of interleukin-12 biosynthetic process (GO:0045075)6.66277639
2regulation of gamma-delta T cell differentiation (GO:0045586)6.42850354
3regulation of gamma-delta T cell activation (GO:0046643)6.07591754
4positive regulation of gamma-delta T cell activation (GO:0046645)6.07308198
5positive regulation of interleukin-2 biosynthetic process (GO:0045086)5.52168385
6NIK/NF-kappaB signaling (GO:0038061)5.13993225
7positive thymic T cell selection (GO:0045059)5.10787966
8endothelial cell chemotaxis (GO:0035767)4.94528751
9myeloid dendritic cell differentiation (GO:0043011)4.91580881
10response to peptidoglycan (GO:0032494)4.83182723
11myeloid dendritic cell activation (GO:0001773)4.62103960
12negative thymic T cell selection (GO:0045060)4.58218502
13negative T cell selection (GO:0043383)4.55115084
14regulation of isotype switching to IgG isotypes (GO:0048302)4.37564861
15regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)4.33896001
16positive T cell selection (GO:0043368)4.27974024
17tolerance induction (GO:0002507)4.21082460
18positive regulation of isotype switching (GO:0045830)4.20634368
19negative regulation of cell killing (GO:0031342)4.20357222
20negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.20357222
21response to muramyl dipeptide (GO:0032495)4.18575996
22interferon-gamma production (GO:0032609)4.17320864
23positive regulation of interleukin-2 production (GO:0032743)4.07144072
24thymic T cell selection (GO:0045061)4.06393415
25macrophage activation involved in immune response (GO:0002281)4.05776074
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.02956665
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.02956665
28antigen processing and presentation of endogenous antigen (GO:0019883)4.01923521
29positive regulation of immunoglobulin mediated immune response (GO:0002891)3.99795271
30positive regulation of B cell mediated immunity (GO:0002714)3.99795271
31regulation of interleukin-2 biosynthetic process (GO:0045076)3.99141706
32response to interleukin-15 (GO:0070672)3.98407604
33regulation of B cell receptor signaling pathway (GO:0050855)3.97444813
34positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.96676464
35leukocyte aggregation (GO:0070486)3.93104372
36regulation of alpha-beta T cell proliferation (GO:0046640)3.86596232
37positive regulation of humoral immune response (GO:0002922)3.86017480
38positive regulation of chemokine biosynthetic process (GO:0045080)3.82771957
39regulation of regulatory T cell differentiation (GO:0045589)3.81091272
40T cell selection (GO:0045058)3.77997793
41CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.77683866
42regulation of immunoglobulin secretion (GO:0051023)3.76399532
43regulation of interferon-beta biosynthetic process (GO:0045357)3.72442859
44defense response to protozoan (GO:0042832)3.68411667
45cellular response to interleukin-15 (GO:0071350)3.66879793
46antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.63984233
47neutrophil activation involved in immune response (GO:0002283)3.62257271
48JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.59236721
49positive regulation of DNA recombination (GO:0045911)3.56934577
50positive regulation of B cell differentiation (GO:0045579)3.54386434
51lipopolysaccharide-mediated signaling pathway (GO:0031663)3.50240474
52T-helper 1 type immune response (GO:0042088)3.47706402
53positive regulation of alpha-beta T cell proliferation (GO:0046641)3.46023640
54T cell migration (GO:0072678)3.44911335
55cellular extravasation (GO:0045123)3.42723997
56response to protozoan (GO:0001562)3.41890308
57regulation of vitamin D biosynthetic process (GO:0060556)3.41100675
58dendritic cell differentiation (GO:0097028)3.37129508
59regulation of T cell tolerance induction (GO:0002664)3.36519816
60regulation of chemokine biosynthetic process (GO:0045073)3.34585239
61regulation of B cell differentiation (GO:0045577)3.32665981
62positive regulation of interleukin-12 production (GO:0032735)3.30689192
63regulation of chronic inflammatory response (GO:0002676)3.30594297
64interferon-gamma-mediated signaling pathway (GO:0060333)3.28528822
65positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.27876536
66T cell receptor signaling pathway (GO:0050852)3.24578700
67regulation of immunoglobulin mediated immune response (GO:0002889)3.24536531
68regulation of B cell mediated immunity (GO:0002712)3.21689721
69B cell receptor signaling pathway (GO:0050853)3.21628523
70regulation of interleukin-2 production (GO:0032663)3.21453714
71negative regulation of T cell mediated immunity (GO:0002710)3.21171068
72mature B cell differentiation (GO:0002335)3.19859251
73positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.19232374
74positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.18500899
75regulation of interleukin-12 production (GO:0032655)3.15170269
76regulation of isotype switching (GO:0045191)3.15036822
77positive regulation of antigen processing and presentation (GO:0002579)3.14823272
78negative regulation of interleukin-12 production (GO:0032695)3.14591199
79regulation of interferon-alpha production (GO:0032647)3.14156494
80myeloid cell activation involved in immune response (GO:0002275)3.13588317
81positive regulation of interleukin-10 production (GO:0032733)3.13573843
82regulation of antigen processing and presentation (GO:0002577)3.11779930
83B cell mediated immunity (GO:0019724)3.10817214
84granulocyte activation (GO:0036230)3.10378361
85regulation of dendritic cell antigen processing and presentation (GO:0002604)3.09953431
86negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.09534491
87cellular response to nicotine (GO:0071316)3.08050117
88positive regulation of T cell cytokine production (GO:0002726)3.05554555
89regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.05383614
90microglial cell activation (GO:0001774)3.03926892
91positive regulation of interferon-alpha production (GO:0032727)3.03885978
92detection of other organism (GO:0098543)3.03662286
93regulation of response to interferon-gamma (GO:0060330)3.03407248
94negative regulation of cytokine production involved in immune response (GO:0002719)3.03157398
95negative regulation of lymphocyte mediated immunity (GO:0002707)3.02524048
96antigen receptor-mediated signaling pathway (GO:0050851)3.01732586
97germinal center formation (GO:0002467)3.01323190
98regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.00743628
99modulation by symbiont of host defense response (GO:0052031)3.00006854
100modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.00006854
101modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.00006854
102positive regulation by organism of defense response of other organism involved in symbiotic interact3.00006854
103modulation by symbiont of host immune response (GO:0052553)3.00006854
104positive regulation by symbiont of host defense response (GO:0052509)3.00006854
105positive regulation of cytokine biosynthetic process (GO:0042108)2.99412641
106regulation of vitamin metabolic process (GO:0030656)2.98775922
107positive regulation of immunoglobulin production (GO:0002639)2.98334309
108activated T cell proliferation (GO:0050798)2.97822329
109regulation of immunoglobulin production (GO:0002637)2.95873349
110response to type I interferon (GO:0034340)2.95803472
111tyrosine phosphorylation of STAT protein (GO:0007260)2.95156577
112detection of bacterium (GO:0016045)2.94773294
113type I interferon signaling pathway (GO:0060337)2.94632270
114cellular response to type I interferon (GO:0071357)2.94632270
115macrophage activation (GO:0042116)2.94549427
116immunoglobulin mediated immune response (GO:0016064)2.94372221
117positive regulation of T cell differentiation (GO:0045582)2.94033163
118regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.93911251
119T cell costimulation (GO:0031295)2.93868592
120positive regulation of NF-kappaB import into nucleus (GO:0042346)2.93414678
121positive regulation of heat generation (GO:0031652)2.93004951
122positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)2.92854350
123T cell lineage commitment (GO:0002360)2.89196862
124positive regulation of interleukin-17 production (GO:0032740)2.89171743
125lymphocyte costimulation (GO:0031294)2.88668363
126neutrophil activation (GO:0042119)2.88648878
127leukocyte cell-cell adhesion (GO:0007159)2.88508350
128positive regulation of B cell proliferation (GO:0030890)2.86981064
129positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.86806888
130response to xenobiotic stimulus (GO:0009410)2.86644434
131positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.86337644
132T cell homeostasis (GO:0043029)2.84894244
133regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.84239600
134natural killer cell activation (GO:0030101)2.82955452
135negative regulation of alpha-beta T cell activation (GO:0046636)2.82720591
136regulation of interferon-gamma biosynthetic process (GO:0045072)2.81836927
137negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.81797894
138modulation of growth of symbiont involved in interaction with host (GO:0044144)2.81797894
139regulation of growth of symbiont in host (GO:0044126)2.81797894
140negative regulation of growth of symbiont in host (GO:0044130)2.81797894
141positive regulation of interferon-beta production (GO:0032728)2.81775101
142positive regulation of B cell activation (GO:0050871)2.80724641
143regulation of natural killer cell mediated immunity (GO:0002715)2.80085284
144regulation of germinal center formation (GO:0002634)2.79950194

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse6.87910297
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.69632716
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.56651226
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.51791131
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.83233896
6STAT3_20064451_ChIP-Seq_CD4+T_Mouse3.82563678
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.52985053
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.48178423
9NOTCH1_21737748_ChIP-Seq_TLL_Human3.34565612
10MYC_22102868_ChIP-Seq_BL_Human3.30147766
11BP1_19119308_ChIP-ChIP_Hs578T_Human3.18897481
12STAT4_19710469_ChIP-ChIP_TH1__Mouse3.14474767
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse3.11029998
14* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.10653724
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.05428319
16RUNX_20019798_ChIP-Seq_JUKART_Human3.05221181
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.86369191
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.81959380
19MYB_26560356_Chip-Seq_TH2_Human2.79324036
20* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.75420233
21SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.71095410
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.70292936
23E2F7_22180533_ChIP-Seq_HELA_Human2.66980628
24MAF_26560356_Chip-Seq_TH1_Human2.57027823
25* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.49061368
26MYB_26560356_Chip-Seq_TH1_Human2.39194017
27VDR_21846776_ChIP-Seq_THP-1_Human2.32777362
28TCF7_22412390_ChIP-Seq_EML_Mouse2.19517023
29SCL_19346495_ChIP-Seq_HPC-7_Human2.15677900
30UTX_26944678_Chip-Seq_JUKART_Human2.08458666
31VDR_24763502_ChIP-Seq_THP-1_Human2.03832456
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.97770353
33RUNX1_22412390_ChIP-Seq_EML_Mouse1.96509879
34KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.95421032
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.92992497
36ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.90012622
37SPI1_23547873_ChIP-Seq_NB4_Human1.89628198
38RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.83582167
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77022312
40CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.76088301
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74553727
42KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.74364721
43* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.72115604
44GATA3_27048872_Chip-Seq_THYMUS_Human1.71921716
45KDM2B_26808549_Chip-Seq_DND41_Human1.65327460
46MAF_26560356_Chip-Seq_TH2_Human1.64729466
47NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.63773631
48Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.53039627
49IKZF1_21737484_ChIP-ChIP_HCT116_Human1.49422637
50SPI1_23127762_ChIP-Seq_K562_Human1.46822243
51PU_27001747_Chip-Seq_BMDM_Mouse1.45723192
52VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.45024049
53MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.40051372
54PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.39695729
55ELF1_17652178_ChIP-ChIP_JURKAT_Human1.31955857
56* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22257359
57BCL6_27268052_Chip-Seq_Bcells_Human1.20833338
58* ELK3_25401928_ChIP-Seq_HUVEC_Human1.20635329
59VDR_24787735_ChIP-Seq_THP-1_Human1.19346924
60CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19276478
61* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.18548352
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.14967112
63TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14813313
64GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14437771
65KDM2B_26808549_Chip-Seq_JURKAT_Human1.14349454
66GATA3_26560356_Chip-Seq_TH2_Human1.13368293
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11593397
68VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11573978
69CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.10767193
70CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.08963457
71CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07303176
72STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07111936
73BCOR_27268052_Chip-Seq_Bcells_Human1.06855326
74RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04451108
75ELF1_20517297_ChIP-Seq_JURKAT_Human1.03000858
76GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02434186
77LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.00970115
78EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.00263312
79PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.99887865
80STAT1_20625510_ChIP-Seq_HELA_Human0.98033438
81PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94049435
82CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.92089679
83NCOR1_26117541_ChIP-Seq_K562_Human0.88954240
84TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88318530
85CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88021345
86PU.1_20513432_ChIP-Seq_Bcells_Mouse0.87891559
87SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.87316123
88FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87198766
89P300_27268052_Chip-Seq_Bcells_Human0.86926461
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.86386240
91GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85739914
92HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85661766
93STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85296490
94GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.84833599
95GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84487311
96GATA1_22025678_ChIP-Seq_K562_Human0.84055731
97SPI1_20517297_ChIP-Seq_HL60_Human0.80288360
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.80145772
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.78609836
100LXR_22292898_ChIP-Seq_THP-1_Human0.77178367
101SMAD_19615063_ChIP-ChIP_OVARY_Human0.76015557
102VDR_23849224_ChIP-Seq_CD4+_Human0.75511329
103GATA1_19941827_ChIP-Seq_MEL_Mouse0.73991488
104BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.73971060
105RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.72410704
106SMRT_27268052_Chip-Seq_Bcells_Human0.71334005
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.69818387
108EGR1_19032775_ChIP-ChIP_M12_Human0.67757530
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.67450361
110CIITA_25753668_ChIP-Seq_RAJI_Human0.67313926
111GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66885389
112TFEB_21752829_ChIP-Seq_HELA_Human0.66652558
113ELK1_19687146_ChIP-ChIP_HELA_Human0.66377413
114SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66041758
115GATA1_19941826_ChIP-Seq_K562_Human0.64777359
116CLOCK_20551151_ChIP-Seq_293T_Human0.64625044
117HOXB4_20404135_ChIP-ChIP_EML_Mouse0.64466856

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.14334520
2MP0000685_abnormal_immune_system3.67883621
3MP0003436_decreased_susceptibility_to3.57023151
4MP0005671_abnormal_response_to3.45612699
5MP0003303_peritoneal_inflammation3.37808793
6MP0004510_myositis3.35239331
7* MP0003763_abnormal_thymus_physiology3.25489656
8MP0001800_abnormal_humoral_immune3.20103618
9MP0005000_abnormal_immune_tolerance3.19524928
10MP0005387_immune_system_phenotype3.19289255
11MP0001790_abnormal_immune_system3.19289255
12MP0009785_altered_susceptibility_to2.81433935
13MP0001853_heart_inflammation2.77026448
14MP0002452_abnormal_antigen_presenting2.76344603
15* MP0002723_abnormal_immune_serum2.75324828
16MP0003300_gastrointestinal_ulcer2.71869293
17MP0002405_respiratory_system_inflammati2.68225564
18* MP0002420_abnormal_adaptive_immunity2.53680560
19MP0002148_abnormal_hypersensitivity_rea2.52971327
20* MP0001819_abnormal_immune_cell2.52276216
21MP0005025_abnormal_response_to2.48699647
22MP0002419_abnormal_innate_immunity2.39602827
23MP0002166_altered_tumor_susceptibility2.34614320
24MP0003724_increased_susceptibility_to2.31381786
25* MP0002398_abnormal_bone_marrow2.31159064
26MP0006082_CNS_inflammation2.22129532
27MP0004947_skin_inflammation2.15805826
28* MP0000716_abnormal_immune_system2.09771871
29MP0009333_abnormal_splenocyte_physiolog2.06682972
30MP0001873_stomach_inflammation2.04540471
31MP0002006_tumorigenesis2.01073821
32MP0000689_abnormal_spleen_morphology1.94556814
33MP0002138_abnormal_hepatobiliary_system1.93377936
34* MP0010155_abnormal_intestine_physiology1.88693205
35MP0002396_abnormal_hematopoietic_system1.87932305
36MP0004808_abnormal_hematopoietic_stem1.86916560
37MP0002722_abnormal_immune_system1.86015811
38MP0003866_abnormal_defecation1.85002768
39MP0000703_abnormal_thymus_morphology1.83075377
40* MP0001845_abnormal_inflammatory_respons1.72590400
41* MP0002429_abnormal_blood_cell1.70283241
42MP0005464_abnormal_platelet_physiology1.67106525
43MP0001533_abnormal_skeleton_physiology1.61827843
44MP0000465_gastrointestinal_hemorrhage1.56395452
45MP0009278_abnormal_bone_marrow1.52971628
46MP0005310_abnormal_salivary_gland1.48515377
47MP0008057_abnormal_DNA_replication1.46577275
48MP0002933_joint_inflammation1.38823256
49MP0001851_eye_inflammation1.33864922
50MP0001545_abnormal_hematopoietic_system1.32149870
51MP0005397_hematopoietic_system_phenotyp1.32149870
52MP0000604_amyloidosis1.29043835
53MP0003448_altered_tumor_morphology1.22712841
54MP0008961_abnormal_basal_metabolism1.22358497
55MP0002998_abnormal_bone_remodeling1.20976538
56MP0008469_abnormal_protein_level1.16814318
57MP0003195_calcinosis1.15065446
58MP0002254_reproductive_system_inflammat1.12805144
59MP0000858_altered_metastatic_potential1.12770653
60MP0005167_abnormal_blood-brain_barrier1.12553518
61MP0010352_gastrointestinal_tract_polyps1.06627178
62MP0003806_abnormal_nucleotide_metabolis1.05743156
63MP0010307_abnormal_tumor_latency1.04457246
64MP0005076_abnormal_cell_differentiation1.02753027
65MP0005423_abnormal_somatic_nervous1.02578887
66MP0009764_decreased_sensitivity_to0.95800245
67MP0002139_abnormal_hepatobiliary_system0.92903840
68MP0005451_abnormal_body_composition0.92899052
69MP0000490_abnormal_crypts_of0.92096650
70MP0003453_abnormal_keratinocyte_physiol0.90127155
71MP0005058_abnormal_lysosome_morphology0.84493136
72MP0002019_abnormal_tumor_incidence0.82385203
73MP0002693_abnormal_pancreas_physiology0.81094930
74MP0005174_abnormal_tail_pigmentation0.80549747
75MP0000015_abnormal_ear_pigmentation0.80342907
76MP0003172_abnormal_lysosome_physiology0.80160030
77MP0000569_abnormal_digit_pigmentation0.79741911
78MP0005390_skeleton_phenotype0.77406088
79MP0002277_abnormal_respiratory_mucosa0.77215585
80MP0008004_abnormal_stomach_pH0.76252990
81MP0005166_decreased_susceptibility_to0.75642994
82MP0003191_abnormal_cellular_cholesterol0.73976077
83MP0003075_altered_response_to0.72716255
84MP0003656_abnormal_erythrocyte_physiolo0.71993978
85MP0003795_abnormal_bone_structure0.71803132
86MP0003045_fibrosis0.69074177
87MP0001501_abnormal_sleep_pattern0.69009739
88MP0004782_abnormal_surfactant_physiolog0.68303794
89MP0008007_abnormal_cellular_replicative0.68036383
90MP0000249_abnormal_blood_vessel0.67682857
91MP0001348_abnormal_lacrimal_gland0.67557016
92MP0004742_abnormal_vestibular_system0.66885118
93MP0009763_increased_sensitivity_to0.64913174
94MP0003183_abnormal_peptide_metabolism0.64223119
95MP0001986_abnormal_taste_sensitivity0.63714326
96MP0005075_abnormal_melanosome_morpholog0.63488965
97MP0009840_abnormal_foam_cell0.62873768
98MP0003828_pulmonary_edema0.62478003
99MP0001663_abnormal_digestive_system0.62363851
100MP0002009_preneoplasia0.61790209
101MP0000609_abnormal_liver_physiology0.61526854
102MP0002132_abnormal_respiratory_system0.61218865
103MP0008260_abnormal_autophagy0.59603654
104MP0003091_abnormal_cell_migration0.58442300
105MP0002332_abnormal_exercise_endurance0.56203436
106MP0002136_abnormal_kidney_physiology0.56034269
107MP0000343_altered_response_to0.55755169
108MP0009765_abnormal_xenobiotic_induced0.54557513
109MP0004381_abnormal_hair_follicle0.54339758
110MP0000371_diluted_coat_color0.53977081
111MP0005647_abnormal_sex_gland0.53736876
112MP0001216_abnormal_epidermal_layer0.53685091
113MP0005535_abnormal_body_temperature0.53594904
114MP0005023_abnormal_wound_healing0.53316743
115MP0001243_abnormal_dermal_layer0.52973882
116MP0001881_abnormal_mammary_gland0.52919859
117MP0003077_abnormal_cell_cycle0.51867151
118MP0000367_abnormal_coat/_hair0.49176201

Predicted human phenotypes

RankGene SetZ-score
1Stomatitis (HP:0010280)7.52297225
2Eczematoid dermatitis (HP:0000976)6.12133958
3Elevated erythrocyte sedimentation rate (HP:0003565)5.76080592
4Recurrent fungal infections (HP:0002841)4.75590739
5Recurrent abscess formation (HP:0002722)4.68996171
6Mediastinal lymphadenopathy (HP:0100721)4.50426875
7Recurrent bacterial skin infections (HP:0005406)4.32995844
8T lymphocytopenia (HP:0005403)4.14389768
9Recurrent viral infections (HP:0004429)4.13019813
10Myositis (HP:0100614)4.12409052
11Abnormality of T cell number (HP:0011839)4.10729041
12Panhypogammaglobulinemia (HP:0003139)3.92499987
13Severe combined immunodeficiency (HP:0004430)3.92442514
14Increased IgM level (HP:0003496)3.86752548
15Abnormality of glycolipid metabolism (HP:0010969)3.84930625
16Abnormality of liposaccharide metabolism (HP:0010968)3.84930625
17Abnormality of glycosphingolipid metabolism (HP:0004343)3.84930625
18Retrobulbar optic neuritis (HP:0100654)3.67883561
19Optic neuritis (HP:0100653)3.67883561
20Abnormality of T cells (HP:0002843)3.63643996
21IgM deficiency (HP:0002850)3.62570474
22Combined immunodeficiency (HP:0005387)3.53878547
23Vasculitis (HP:0002633)3.53061519
24Orchitis (HP:0100796)3.52890396
25Chronic mucocutaneous candidiasis (HP:0002728)3.50054408
26Recurrent cutaneous fungal infections (HP:0011370)3.50054408
27IgG deficiency (HP:0004315)3.46016675
28B lymphocytopenia (HP:0010976)3.39437710
29Abnormality of B cell number (HP:0010975)3.39437710
30Recurrent bronchitis (HP:0002837)3.39129935
31Pulmonary infiltrates (HP:0002113)3.37194985
32Increased cerebral lipofuscin (HP:0011813)3.33598951
33IgA deficiency (HP:0002720)3.29014320
34Recurrent skin infections (HP:0001581)3.26616649
35Leukocytosis (HP:0001974)3.20905688
36Chronic diarrhea (HP:0002028)3.19931057
37Vacuolated lymphocytes (HP:0001922)3.19746073
38Chronic otitis media (HP:0000389)3.17523943
39Abnormal delayed hypersensitivity skin test (HP:0002963)3.13692245
40Increased neuronal autofluorescent lipopigment (HP:0002074)3.12689908
41Gingivitis (HP:0000230)3.11352006
42Abnormality of T cell physiology (HP:0011840)3.10946830
43Gastrointestinal infarctions (HP:0005244)3.09370731
44Arterial thrombosis (HP:0004420)3.08901186
45Thyroiditis (HP:0100646)3.02767950
46Nasal polyposis (HP:0100582)3.02348420
47Thrombocytosis (HP:0001894)3.01873775
48Increased density of long bones (HP:0006392)3.01318371
49Abnormality of the fingertips (HP:0001211)2.97334790
50Obstructive lung disease (HP:0006536)2.95824807
51Chronic obstructive pulmonary disease (HP:0006510)2.95824807
52Autoimmune thrombocytopenia (HP:0001973)2.93368871
53Eosinophilia (HP:0001880)2.91802814
54Meningitis (HP:0001287)2.88984847
55Recurrent gram-negative bacterial infections (HP:0005420)2.87936355
56Persistence of primary teeth (HP:0006335)2.85349192
57Abnormality of eosinophils (HP:0001879)2.85072025
58Lymphopenia (HP:0001888)2.84888248
59Pustule (HP:0200039)2.81398215
60Abnormality of cells of the lymphoid lineage (HP:0012140)2.80190438
61Inflammation of the large intestine (HP:0002037)2.80143764
62Dysostosis multiplex (HP:0000943)2.79694753
63Autoimmune hemolytic anemia (HP:0001890)2.74257340
64Gastrointestinal stroma tumor (HP:0100723)2.73662370
65Abnormality of macrophages (HP:0004311)2.72536799
66Polyneuropathy (HP:0001271)2.71121317
67Colitis (HP:0002583)2.68290280
68Gastrointestinal inflammation (HP:0004386)2.65355112
69Agammaglobulinemia (HP:0004432)2.63980028
70Hemoptysis (HP:0002105)2.60752075
71Cellulitis (HP:0100658)2.60052626
72Increased IgE level (HP:0003212)2.60026710
73Abnormality of the nasal mucosa (HP:0000433)2.58808931
74Gangrene (HP:0100758)2.58607511
75Urticaria (HP:0001025)2.56396316
76Hypergammaglobulinemia (HP:0010702)2.52475381
77Granulocytopenia (HP:0001913)2.50357525
78Spontaneous hematomas (HP:0007420)2.50250074
79Lymphoma (HP:0002665)2.49622015
80Chest pain (HP:0100749)2.48639082
81Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.48459206
82Recurrent sinusitis (HP:0011108)2.45235882
83Loss of speech (HP:0002371)2.44750149
84Periodontitis (HP:0000704)2.41797145
85Fatigue (HP:0012378)2.41603900
86Abnormality of the pleura (HP:0002103)2.37348353
87Keratoconjunctivitis sicca (HP:0001097)2.36759820
88Myocardial infarction (HP:0001658)2.35312330
89Interstitial pulmonary disease (HP:0006530)2.33338051
90Abnormality of the prostate (HP:0008775)2.31646909
91Emphysema (HP:0002097)2.26444275
92Osteomyelitis (HP:0002754)2.25469543
93Gingival bleeding (HP:0000225)2.25419877
94Joint swelling (HP:0001386)2.25344674
95Increased serum ferritin (HP:0003281)2.23623643
96Disinhibition (HP:0000734)2.23245574
97Keratoconjunctivitis (HP:0001096)2.19134121
98Amaurosis fugax (HP:0100576)2.19055061
99Amyloidosis (HP:0011034)2.15588754
100Anorexia (HP:0002039)2.14425360
101Encephalitis (HP:0002383)2.12895885
102Epistaxis (HP:0000421)2.12872673
103Mutism (HP:0002300)2.10482549
104Peripheral hypomyelination (HP:0007182)2.10286701
105Acute myeloid leukemia (HP:0004808)2.10025741
106Segmental peripheral demyelination/remyelination (HP:0003481)2.09919994
107Abnormality of mucopolysaccharide metabolism (HP:0011020)2.09434018
108Abnormality of polysaccharide metabolism (HP:0011012)2.09434018
109Abnormality of glycosaminoglycan metabolism (HP:0004371)2.09434018
110Episodic fever (HP:0001954)2.09425648
111Sepsis (HP:0100806)2.07627438
112Hematochezia (HP:0002573)2.06004381
113Recurrent pneumonia (HP:0006532)2.04517414
114Restrictive lung disease (HP:0002091)2.02362022
115Alveolar cell carcinoma (HP:0006519)2.01502598
116Somatic mutation (HP:0001428)2.00838818
117Prolonged bleeding time (HP:0003010)1.91937968
118Arthralgia (HP:0002829)1.89845148
119Upper limb muscle weakness (HP:0003484)1.87302335
120Hepatitis (HP:0012115)1.87130186
121Skin ulcer (HP:0200042)1.86845818
122Petechiae (HP:0000967)1.86036631
123Premature loss of primary teeth (HP:0006323)1.85350707
124Systemic lupus erythematosus (HP:0002725)1.84639739
125Pulmonary embolism (HP:0002204)1.84550312
126Leukopenia (HP:0001882)1.83486024

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K15.42441441
2TXK4.55695654
3MAP3K144.37436378
4IKBKB2.90322073
5JAK32.82875327
6ZAP702.79998709
7TBK12.55313277
8CHUK2.45957659
9IKBKE2.45418891
10TYK22.44743037
11ITK2.39686352
12MAP3K102.10000221
13STK101.90238434
14IRAK31.88023508
15PIM21.86539461
16TEC1.82303881
17TNK21.75859662
18IRAK41.72852224
19TGFBR21.68192915
20BTK1.65918542
21JAK11.62401244
22PRPF4B1.59222747
23MATK1.57256363
24RIPK41.57090202
25MAP3K131.56040882
26MAP2K31.55075172
27PIM11.54173063
28LCK1.51203964
29HCK1.50432446
30CDK121.49198335
31RPS6KA41.48425504
32GRK61.46645498
33EPHB11.44986755
34SYK1.41532519
35GRK71.39842801
36CSK1.39755491
37BLK1.39577554
38FGFR41.38335202
39NLK1.33361372
40TSSK61.31615866
41IRAK21.26800706
42ACVR1B1.22854239
43FGFR31.21594279
44MAP3K111.20874039
45KIT1.18864493
46CSF1R1.14298695
47EPHA31.09284345
48ADRBK21.08286644
49RPS6KA51.07977324
50MAP3K31.03206298
51JAK20.99525166
52TAOK10.96842224
53MST40.96828086
54CLK10.92005020
55EEF2K0.91126040
56CAMKK20.86903360
57LYN0.86876730
58MARK30.86227304
59TAOK30.83547662
60ERN10.82064594
61FES0.81353285
62RPS6KA10.74775744
63CAMK1D0.73540267
64BRD40.71985589
65SIK20.70436600
66CDC42BPA0.70172046
67SIK30.65945679
68PRKCQ0.65090382
69MAP2K60.63638849
70LRRK20.63445181
71TAOK20.60507375
72NUAK10.59460975
73PTK60.58179946
74MAPK120.58002066
75TLK10.56702121
76ALK0.56557612
77DAPK20.56268090
78BMPR20.52807217
79MAP3K70.51794271
80RAF10.51002926
81PRKD20.49154400
82MAPKAPK20.48427084
83PDGFRB0.47639428
84SMG10.47243854
85FRK0.47207756
86CDK90.46103957
87HIPK20.45982307
88MELK0.44907251
89MAP3K10.44824840
90GSK3A0.43066173
91IRAK10.42620961
92MAP3K80.42143855
93TESK20.40540293
94ABL10.40501184
95PRKCH0.40302751
96MAPK150.39550420
97CAMKK10.38930997
98EGFR0.38217163
99EIF2AK20.37326434
100INSR0.35077216
101MAP3K50.34744750
102BCKDK0.34658982
103PDK10.32996132
104CDK40.32700245
105MARK20.32110029
106BMX0.32080764
107RPS6KA60.31767781
108TRIB30.31762088
109FLT30.30480346
110TGFBR10.30299301
111MAP2K20.29283341
112MAPK70.29004487
113MOS0.28821235
114CDK60.28755583
115NME20.28516736
116RIPK10.28476890
117MAPK30.27259102
118STK40.27085256
119DDR20.25171805
120KSR20.25157526
121MAPK40.24612811
122RPS6KL10.24511358
123RPS6KC10.24511358
124PRKAA20.23993536
125NEK90.23872439
126MAPK10.21882397
127FYN0.21404872
128KDR0.21329248
129PAK20.20822299
130FGR0.20155664
131SIK10.20098626
132TRPM70.19894635
133ABL20.18556677

Predicted pathways (KEGG)

RankGene SetZ-score
1Allograft rejection_Homo sapiens_hsa053303.48532767
2NF-kappa B signaling pathway_Homo sapiens_hsa040643.33728646
3Primary immunodeficiency_Homo sapiens_hsa053403.08915157
4Graft-versus-host disease_Homo sapiens_hsa053322.93757151
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.91376472
6Leishmaniasis_Homo sapiens_hsa051402.75720484
7T cell receptor signaling pathway_Homo sapiens_hsa046602.74073690
8Osteoclast differentiation_Homo sapiens_hsa043802.63788639
9Intestinal immune network for IgA production_Homo sapiens_hsa046722.46948953
10Measles_Homo sapiens_hsa051622.39591625
11Asthma_Homo sapiens_hsa053102.39422221
12NOD-like receptor signaling pathway_Homo sapiens_hsa046212.24091036
13B cell receptor signaling pathway_Homo sapiens_hsa046622.18490219
14Type I diabetes mellitus_Homo sapiens_hsa049402.09210634
15Autoimmune thyroid disease_Homo sapiens_hsa053202.04805282
16TNF signaling pathway_Homo sapiens_hsa046681.97670304
17RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.95234940
18Toll-like receptor signaling pathway_Homo sapiens_hsa046201.86571654
19Legionellosis_Homo sapiens_hsa051341.85789627
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.83600168
21Antigen processing and presentation_Homo sapiens_hsa046121.81522246
22Hematopoietic cell lineage_Homo sapiens_hsa046401.77611473
23Jak-STAT signaling pathway_Homo sapiens_hsa046301.76810461
24Toxoplasmosis_Homo sapiens_hsa051451.75462291
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.73229729
26Herpes simplex infection_Homo sapiens_hsa051681.64753467
27Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.51037643
28Acute myeloid leukemia_Homo sapiens_hsa052211.50235578
29Influenza A_Homo sapiens_hsa051641.47274394
30Hepatitis B_Homo sapiens_hsa051611.45963724
31Malaria_Homo sapiens_hsa051441.41764089
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.41150130
33Pertussis_Homo sapiens_hsa051331.40985071
34Apoptosis_Homo sapiens_hsa042101.38627241
35Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.35569347
36Tuberculosis_Homo sapiens_hsa051521.34978408
37Chemokine signaling pathway_Homo sapiens_hsa040621.31888209
38Shigellosis_Homo sapiens_hsa051311.24968644
39Chronic myeloid leukemia_Homo sapiens_hsa052201.24884817
40Viral myocarditis_Homo sapiens_hsa054161.23880723
41Staphylococcus aureus infection_Homo sapiens_hsa051501.21866428
42AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.16308213
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14388798
44Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.12873963
45Prolactin signaling pathway_Homo sapiens_hsa049171.11902544
46Salmonella infection_Homo sapiens_hsa051321.10175914
47Rheumatoid arthritis_Homo sapiens_hsa053231.09096067
48Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.08359995
49Epstein-Barr virus infection_Homo sapiens_hsa051691.07215242
50HTLV-I infection_Homo sapiens_hsa051661.03287678
51Hepatitis C_Homo sapiens_hsa051600.93651543
52African trypanosomiasis_Homo sapiens_hsa051430.92401590
53Viral carcinogenesis_Homo sapiens_hsa052030.91753073
54Pancreatic cancer_Homo sapiens_hsa052120.87761868
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.85646386
56Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.82161257
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.82036206
58Small cell lung cancer_Homo sapiens_hsa052220.79778450
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.73570975
60MAPK signaling pathway_Homo sapiens_hsa040100.71006671
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.63064537
62Platelet activation_Homo sapiens_hsa046110.61943748
63VEGF signaling pathway_Homo sapiens_hsa043700.50925616
64Colorectal cancer_Homo sapiens_hsa052100.50865086
65Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50549428
66Amoebiasis_Homo sapiens_hsa051460.48781452
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45101080
68Insulin resistance_Homo sapiens_hsa049310.44814213
69Collecting duct acid secretion_Homo sapiens_hsa049660.43641747
70MicroRNAs in cancer_Homo sapiens_hsa052060.43143830
71FoxO signaling pathway_Homo sapiens_hsa040680.39487489
72Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.39286782
73Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.38473451
74Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.38391563
75Type II diabetes mellitus_Homo sapiens_hsa049300.37004966
76HIF-1 signaling pathway_Homo sapiens_hsa040660.36814014
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.36151464
78Non-homologous end-joining_Homo sapiens_hsa034500.35468563
79Notch signaling pathway_Homo sapiens_hsa043300.35335485
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34941974
81Lysosome_Homo sapiens_hsa041420.33502083
82Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33177730
83p53 signaling pathway_Homo sapiens_hsa041150.32445386
84Prostate cancer_Homo sapiens_hsa052150.32161060
85Other glycan degradation_Homo sapiens_hsa005110.30814388
86Regulation of autophagy_Homo sapiens_hsa041400.30017117
87Prion diseases_Homo sapiens_hsa050200.29870598
88Bladder cancer_Homo sapiens_hsa052190.29732268
89Glycosaminoglycan degradation_Homo sapiens_hsa005310.29683198
90Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.29618561
91Non-small cell lung cancer_Homo sapiens_hsa052230.27413138
92Endocytosis_Homo sapiens_hsa041440.26891078
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.24935641
94mTOR signaling pathway_Homo sapiens_hsa041500.23495662
95Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.23076219
96Spliceosome_Homo sapiens_hsa030400.22826195
97Renal cell carcinoma_Homo sapiens_hsa052110.21217086
98Dorso-ventral axis formation_Homo sapiens_hsa043200.20344851
99Pathways in cancer_Homo sapiens_hsa052000.19730434
100Carbohydrate digestion and absorption_Homo sapiens_hsa049730.19423566
101Phagosome_Homo sapiens_hsa041450.18492753
102Inositol phosphate metabolism_Homo sapiens_hsa005620.18398185
103One carbon pool by folate_Homo sapiens_hsa006700.18184641
104RNA degradation_Homo sapiens_hsa030180.17676640
105Regulation of actin cytoskeleton_Homo sapiens_hsa048100.17400748
106Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.16319841
107Sphingolipid metabolism_Homo sapiens_hsa006000.15526567
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.15117659
109Systemic lupus erythematosus_Homo sapiens_hsa053220.14585532
110Proteoglycans in cancer_Homo sapiens_hsa052050.14281795
111Thyroid hormone signaling pathway_Homo sapiens_hsa049190.12855935
112Ether lipid metabolism_Homo sapiens_hsa005650.11007430
113Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.10672939
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.10462233
115alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.07894048
116Phospholipase D signaling pathway_Homo sapiens_hsa040720.05370026
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.04995397
118Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.03344066
119Arachidonic acid metabolism_Homo sapiens_hsa005900.00505350

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