NFKBIL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a divergent member of the I-kappa-B family of proteins. Its function has not been determined. The gene lies within the major histocompatibility complex (MHC) class I region on chromosome 6. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein retention in ER lumen (GO:0006621)5.48462379
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.43113655
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.43113655
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.90782834
5antigen processing and presentation of endogenous antigen (GO:0019883)4.68468623
6amyloid precursor protein catabolic process (GO:0042987)4.52647216
7regulation of mammary gland epithelial cell proliferation (GO:0033599)4.23897683
8antigen processing and presentation via MHC class Ib (GO:0002475)4.22779602
9viral protein processing (GO:0019082)4.21020088
10DNA deamination (GO:0045006)4.11942671
11deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.10488445
12positive regulation of gamma-delta T cell activation (GO:0046645)3.95914586
13ribosomal small subunit assembly (GO:0000028)3.90878014
14protein maturation by protein folding (GO:0022417)3.90026377
15metallo-sulfur cluster assembly (GO:0031163)3.86879569
16iron-sulfur cluster assembly (GO:0016226)3.86879569
17protein insertion into membrane (GO:0051205)3.86794182
18maturation of SSU-rRNA (GO:0030490)3.82904162
19negative regulation of erythrocyte differentiation (GO:0045647)3.78905918
20mitochondrial calcium ion transport (GO:0006851)3.78007179
21negative regulation of DNA-templated transcription, elongation (GO:0032785)3.76611186
22nuclear envelope reassembly (GO:0031468)3.72938633
23mitotic nuclear envelope reassembly (GO:0007084)3.72938633
24GDP-mannose metabolic process (GO:0019673)3.68023712
25virion assembly (GO:0019068)3.64264253
26mitochondrial fusion (GO:0008053)3.49106566
27macromolecular complex disassembly (GO:0032984)3.48066668
28retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.46393931
29regulation of gamma-delta T cell differentiation (GO:0045586)3.43613356
30adenine nucleotide transport (GO:0051503)3.42683246
31UV protection (GO:0009650)3.41620414
32viral transcription (GO:0019083)3.40222889
33regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.37048312
34negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.36403114
35regulation of gamma-delta T cell activation (GO:0046643)3.36223088
36endoplasmic reticulum calcium ion homeostasis (GO:0032469)3.29704812
37Arp2/3 complex-mediated actin nucleation (GO:0034314)3.21717806
38translational termination (GO:0006415)3.17700783
39protein targeting to membrane (GO:0006612)3.16687050
40activation of MAPKKK activity (GO:0000185)3.14998444
41folic acid-containing compound biosynthetic process (GO:0009396)3.13464379
42T cell apoptotic process (GO:0070231)3.13068342
43post-embryonic morphogenesis (GO:0009886)3.09686055
44positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling3.09560268
45positive regulation of B cell differentiation (GO:0045579)3.08856773
46formation of translation preinitiation complex (GO:0001731)3.08675943
47NIK/NF-kappaB signaling (GO:0038061)3.06629631
48translational elongation (GO:0006414)3.04050828
49antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.01032284
50positive regulation of release of cytochrome c from mitochondria (GO:0090200)2.94506784
51prostaglandin biosynthetic process (GO:0001516)2.94485353
52prostanoid biosynthetic process (GO:0046457)2.94485353
53proline metabolic process (GO:0006560)2.93853351
54positive regulation of T cell apoptotic process (GO:0070234)2.93100532
55positive regulation by symbiont of host defense response (GO:0052509)2.90446452
56modulation by symbiont of host defense response (GO:0052031)2.90446452
57modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.90446452
58modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.90446452
59positive regulation by organism of defense response of other organism involved in symbiotic interact2.90446452
60modulation by symbiont of host immune response (GO:0052553)2.90446452
61pinocytosis (GO:0006907)2.86909970
62ribonucleoprotein complex biogenesis (GO:0022613)2.85154319
63pentose metabolic process (GO:0019321)2.84713921
64mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.83227265
65SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.82615593
66pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.82037069
67pentose-phosphate shunt (GO:0006098)2.81919297
68modulation by virus of host process (GO:0019054)2.81202013
69purine nucleotide transport (GO:0015865)2.81095388
70glucose catabolic process (GO:0006007)2.79228425
71response to misfolded protein (GO:0051788)2.78126043
72regulation of hydrogen peroxide metabolic process (GO:0010310)2.77520947
73modulation by virus of host morphology or physiology (GO:0019048)2.77487418
74purine ribonucleotide transport (GO:0015868)2.76151891
75negative regulation of interleukin-12 production (GO:0032695)2.75691271
76amyloid precursor protein metabolic process (GO:0042982)2.74446598
773-UTR-mediated mRNA stabilization (GO:0070935)2.74368850
78peptidyl-arginine omega-N-methylation (GO:0035247)2.74137970
79proline biosynthetic process (GO:0006561)2.72750240
80protein targeting to ER (GO:0045047)2.71784844
81lymphocyte apoptotic process (GO:0070227)2.71572021
82positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.71123559
83positive regulation of lymphocyte apoptotic process (GO:0070230)2.70923754
84translational initiation (GO:0006413)2.69544772
85cell-cell junction maintenance (GO:0045217)2.68353524
86positive regulation of protein homooligomerization (GO:0032464)2.68239749
87apoptotic process involved in development (GO:1902742)2.67976550
88regulation of cholesterol biosynthetic process (GO:0045540)2.67142055
89nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.67095250
90regulation of autophagic vacuole assembly (GO:2000785)2.66460751
91cotranslational protein targeting to membrane (GO:0006613)2.65721186
92immunoglobulin mediated immune response (GO:0016064)2.64313961
93negative regulation of autophagy (GO:0010507)2.64116051
94glucose 6-phosphate metabolic process (GO:0051156)2.64093200
95regulation of necroptotic process (GO:0060544)2.63669814
96regulation of type I interferon-mediated signaling pathway (GO:0060338)2.63424984
97regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway 2.61306907
98modulation by symbiont of host cellular process (GO:0044068)2.61077071
99guanosine-containing compound biosynthetic process (GO:1901070)2.59759874
100maintenance of protein localization in organelle (GO:0072595)2.59363259
101positive regulation of Cdc42 GTPase activity (GO:0043089)2.59351592
102endothelial cell chemotaxis (GO:0035767)2.59022229
103positive regulation of histone deacetylation (GO:0031065)2.57969278
104intracellular estrogen receptor signaling pathway (GO:0030520)2.57896104
105positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.55691199
106establishment of protein localization to endoplasmic reticulum (GO:0072599)2.55606448
107protein localization to endoplasmic reticulum (GO:0070972)2.55251169
108maternal placenta development (GO:0001893)2.54493841
109positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.53642398
110regulation of release of cytochrome c from mitochondria (GO:0090199)2.52893934
111morphogenesis of an endothelium (GO:0003159)2.52837598
112endothelial tube morphogenesis (GO:0061154)2.52837598
113viral life cycle (GO:0019058)2.52127923
114regulation of B cell differentiation (GO:0045577)2.51917386
115regulation of interferon-beta biosynthetic process (GO:0045357)2.50944995
116positive regulation of mitochondrion organization (GO:0010822)2.50474751
117positive regulation of protein sumoylation (GO:0033235)2.50306554
118barbed-end actin filament capping (GO:0051016)2.50103994
119ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.49825721
120regulation of early endosome to late endosome transport (GO:2000641)2.49217779
121ribosomal small subunit biogenesis (GO:0042274)2.48390454
122establishment of protein localization to membrane (GO:0090150)2.47835763
123sequestering of actin monomers (GO:0042989)2.47125084
124positive regulation of protein deacetylation (GO:0090312)2.46272984
125regulation of translational fidelity (GO:0006450)2.46211331
126negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.45518456
127intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.45433661
128regulation of interleukin-12 biosynthetic process (GO:0045075)2.43897362
129negative regulation of cell size (GO:0045792)2.42266951
130pyrimidine nucleoside salvage (GO:0043097)2.41251089
131pyrimidine-containing compound salvage (GO:0008655)2.41251089
132response to interferon-beta (GO:0035456)2.41069995
133negative regulation of granulocyte differentiation (GO:0030853)2.41014371
134camera-type eye morphogenesis (GO:0048593)2.40749535
135ncRNA 3-end processing (GO:0043628)2.38206327
136regulation of B cell receptor signaling pathway (GO:0050855)2.38128932
137IMP biosynthetic process (GO:0006188)2.37963246
138cellular protein complex disassembly (GO:0043624)2.37410991
139DNA unwinding involved in DNA replication (GO:0006268)2.36908766
140regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.35960994
141natural killer cell differentiation (GO:0001779)2.34096652
142DNA strand elongation involved in DNA replication (GO:0006271)2.33188104
143leukocyte apoptotic process (GO:0071887)2.32570826
144NADPH regeneration (GO:0006740)2.32095922
145regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.31228337
146protein complex disassembly (GO:0043241)2.29567279
147B cell mediated immunity (GO:0019724)2.28760441
148regulation of erythrocyte differentiation (GO:0045646)2.27635368
149negative regulation of phagocytosis (GO:0050765)2.27552987
150response to interferon-alpha (GO:0035455)2.27303241
151lipopolysaccharide biosynthetic process (GO:0009103)2.27297922
152positive regulation of natural killer cell differentiation (GO:0032825)2.26461337
153DNA strand elongation (GO:0022616)2.26158014
154* negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.25473277
155telomere maintenance via semi-conservative replication (GO:0032201)2.25433310
156negative regulation of innate immune response (GO:0045824)2.25318749
157pteridine-containing compound biosynthetic process (GO:0042559)2.24667314
158execution phase of apoptosis (GO:0097194)2.24141240
159response to peptidoglycan (GO:0032494)2.22656526
160actin nucleation (GO:0045010)2.21957226
161negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.21653313
162apoptotic process involved in morphogenesis (GO:0060561)2.21443247
163negative regulation of necroptotic process (GO:0060546)2.21053580
164oxaloacetate metabolic process (GO:0006107)2.20915842
165nucleotide salvage (GO:0043173)2.20492553
166COPI coating of Golgi vesicle (GO:0048205)2.19246780
167Golgi transport vesicle coating (GO:0048200)2.19246780
168positive thymic T cell selection (GO:0045059)2.17840584
169lymph node development (GO:0048535)2.17459261
170positive regulation of macrophage differentiation (GO:0045651)2.16831241
171daunorubicin metabolic process (GO:0044597)2.16698297
172polyketide metabolic process (GO:0030638)2.16698297
173doxorubicin metabolic process (GO:0044598)2.16698297
174T cell homeostasis (GO:0043029)2.16626640
175response to protozoan (GO:0001562)2.16623746
176regulation of response to interferon-gamma (GO:0060330)2.16332525
177mature B cell differentiation involved in immune response (GO:0002313)2.15705393

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.81044369
2E2F7_22180533_ChIP-Seq_HELA_Human3.44230362
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.15726866
4MYC_22102868_ChIP-Seq_BL_Human2.81812016
5VDR_21846776_ChIP-Seq_THP-1_Human2.71390937
6EGR1_19374776_ChIP-ChIP_THP-1_Human2.43651415
7THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.43229471
8MYC_18555785_ChIP-Seq_MESCs_Mouse2.32905336
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.30983186
10SRY_22984422_ChIP-ChIP_TESTIS_Rat2.15809466
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.11688172
12SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.11042549
13FOXM1_23109430_ChIP-Seq_U2OS_Human2.03535757
14* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.00864119
15SCL_19346495_ChIP-Seq_HPC-7_Human1.97364731
16TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96470725
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.95924769
18* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.91171293
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.90029363
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.82286328
21ZNF263_19887448_ChIP-Seq_K562_Human1.81682691
22* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.79588562
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78988896
24MYB_21317192_ChIP-Seq_ERMYB_Mouse1.78034146
25ERG_21242973_ChIP-ChIP_JURKAT_Human1.75624774
26MAF_26560356_Chip-Seq_TH1_Human1.73570479
27IRF8_21731497_ChIP-ChIP_J774_Mouse1.72834210
28ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.71580459
29* TCF7_22412390_ChIP-Seq_EML_Mouse1.71291514
30CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.70256376
31TP63_17297297_ChIP-ChIP_HaCaT_Human1.67935740
32MYC_18358816_ChIP-ChIP_MESCs_Mouse1.67756990
33VDR_24763502_ChIP-Seq_THP-1_Human1.66968340
34* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.65486598
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.65202674
36SA1_27219007_Chip-Seq_ERYTHROID_Human1.63536502
37BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58054453
38UTX_26944678_Chip-Seq_JUKART_Human1.57994521
39SMC4_20622854_ChIP-Seq_HELA_Human1.57818119
40SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.56845160
41RUNX1_22412390_ChIP-Seq_EML_Mouse1.56519083
42* SPI1_23547873_ChIP-Seq_NB4_Human1.56441695
43MYC_19079543_ChIP-ChIP_MESCs_Mouse1.56262344
44THAP11_20581084_ChIP-Seq_MESCs_Mouse1.54003105
45NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.52502914
46SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.52313478
47ELF1_17652178_ChIP-ChIP_JURKAT_Human1.50230309
48XRN2_22483619_ChIP-Seq_HELA_Human1.49366453
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.47319940
50CTCF_27219007_Chip-Seq_ERYTHROID_Human1.47193116
51CIITA_25753668_ChIP-Seq_RAJI_Human1.46243106
52* CTCF_18555785_ChIP-Seq_MESCs_Mouse1.45606126
53LXR_22292898_ChIP-Seq_THP-1_Human1.44788300
54EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.44349377
55GATA1_22383799_ChIP-Seq_G1ME_Mouse1.44284028
56STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.44144229
57NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.43848682
58PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.43496511
59MYB_26560356_Chip-Seq_TH1_Human1.42491825
60UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.41308990
61FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.40878536
62DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39633510
63MYC_19030024_ChIP-ChIP_MESCs_Mouse1.38678729
64MYB_26560356_Chip-Seq_TH2_Human1.38328481
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.38310874
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36574949
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.35974325
68MAF_26560356_Chip-Seq_TH2_Human1.35793078
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.35490530
70* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35250681
71* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34648943
72* ETS1_20019798_ChIP-Seq_JURKAT_Human1.34392771
73KDM2B_26808549_Chip-Seq_K562_Human1.34005324
74* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33329415
75* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.33284672
76* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.32663439
77STAT4_19710469_ChIP-ChIP_TH1__Mouse1.30827315
78SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.30762848
79CREB1_26743006_Chip-Seq_LNCaP_Human1.29363129
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.28828107
81CTCF_27219007_Chip-Seq_Bcells_Human1.27514172
82IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.27383991
83ERG_20887958_ChIP-Seq_HPC-7_Mouse1.24713579
84IRF8_27001747_Chip-Seq_BMDM_Mouse1.24609827
85STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23996717
86* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.23548862
87KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23390141
88VDR_23849224_ChIP-Seq_CD4+_Human1.22962874
89ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.22722685
90SA1_27219007_Chip-Seq_Bcells_Human1.22428893
91NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22195080
92MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.21516440
93CTCF_26484167_Chip-Seq_Bcells_Mouse1.21241771
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21197282
95SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.20035848
96KDM2B_26808549_Chip-Seq_DND41_Human1.19655650
97PHF8_20622854_ChIP-Seq_HELA_Human1.19374383
98* FOXP1_21924763_ChIP-Seq_HESCs_Human1.18142824
99DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18050006
100MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17488768
101GABP_19822575_ChIP-Seq_HepG2_Human1.15829325
102YY1_21170310_ChIP-Seq_MESCs_Mouse1.15822490
103* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15561660
104NELFA_20434984_ChIP-Seq_ESCs_Mouse1.15465134
105NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.15329107
106PPARA_22158963_ChIP-Seq_LIVER_Mouse1.15087734
107TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.14140318
108BCL6_27268052_Chip-Seq_Bcells_Human1.14041042
109CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13122321
110FOXP3_21729870_ChIP-Seq_TREG_Human1.13004794
111* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12453814
112KDM2B_26808549_Chip-Seq_JURKAT_Human1.12148298
113GATA1_22025678_ChIP-Seq_K562_Human1.12117556
114KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11844512
115KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11803978
116HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10767830
117E2F4_17652178_ChIP-ChIP_JURKAT_Human1.10412889
118TFEB_21752829_ChIP-Seq_HELA_Human1.10267800
119CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10180050
120TP53_22127205_ChIP-Seq_IMR90_Human1.09822683
121CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.09790812
122E2F1_20622854_ChIP-Seq_HELA_Human1.08201894
123BCOR_27268052_Chip-Seq_Bcells_Human1.07903315
124E2F1_18555785_ChIP-Seq_MESCs_Mouse1.06852425
125SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06207131
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05994978
127CTCF_21964334_Chip-Seq_Bcells_Human1.05617358
128ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05589044
129RACK7_27058665_Chip-Seq_MCF-7_Human1.05504051
130RARA_24833708_ChIP-Seq_LIVER_Mouse1.05307393
131NCOR1_26117541_ChIP-Seq_K562_Human1.04998593
132* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04847575
133* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.04375698
134CTCF_21964334_ChIP-Seq_BJAB-B_Human1.04254345
135SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.04026723
136KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.02656472
137* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.02512471
138EST1_17652178_ChIP-ChIP_JURKAT_Human1.02503104
139RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02025136
140* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.01361905
141ELF1_20517297_ChIP-Seq_JURKAT_Human0.99960809
142YY1_22570637_ChIP-Seq_MALME-3M_Human0.99661499
143PU.1_20513432_ChIP-Seq_Bcells_Mouse0.99555517
144CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99464912
145DCP1A_22483619_ChIP-Seq_HELA_Human0.99423677
146PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.99299696
147P68_20966046_ChIP-Seq_HELA_Human0.98337586
148* CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.97966728
149TET1_21451524_ChIP-Seq_MESCs_Mouse0.97621316
150HOXB4_20404135_ChIP-ChIP_EML_Mouse0.97560312

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005451_abnormal_body_composition4.25361862
2MP0009379_abnormal_foot_pigmentation4.08488183
3MP0010030_abnormal_orbit_morphology3.82483572
4MP0004858_abnormal_nervous_system3.36518755
5MP0006292_abnormal_olfactory_placode3.29638481
6MP0002653_abnormal_ependyma_morphology3.25699764
7MP0008260_abnormal_autophagy2.90599366
8MP0000685_abnormal_immune_system2.79080749
9MP0001835_abnormal_antigen_presentation2.75481376
10MP0002249_abnormal_larynx_morphology2.69430874
11MP0000678_abnormal_parathyroid_gland2.63897765
12MP0003436_decreased_susceptibility_to2.61293937
13MP0009278_abnormal_bone_marrow2.59245563
14MP0008789_abnormal_olfactory_epithelium2.54406353
15MP0009840_abnormal_foam_cell2.49931174
16MP0005499_abnormal_olfactory_system2.49161709
17MP0005394_taste/olfaction_phenotype2.49161709
18MP0001545_abnormal_hematopoietic_system2.41602583
19MP0005397_hematopoietic_system_phenotyp2.41602583
20MP0003303_peritoneal_inflammation2.39155402
21MP0002396_abnormal_hematopoietic_system2.33883403
22MP0003329_amyloid_beta_deposits2.26243904
23MP0003693_abnormal_embryo_hatching2.15380899
24MP0005464_abnormal_platelet_physiology2.09561974
25MP0000750_abnormal_muscle_regeneration2.03177797
26MP0003763_abnormal_thymus_physiology2.02804639
27MP0001800_abnormal_humoral_immune2.02244733
28MP0009785_altered_susceptibility_to2.00930130
29MP0000490_abnormal_crypts_of1.95201929
30MP0009333_abnormal_splenocyte_physiolog1.94141971
31MP0005025_abnormal_response_to1.93136393
32MP0000049_abnormal_middle_ear1.91119405
33MP0005000_abnormal_immune_tolerance1.88828534
34MP0002452_abnormal_antigen_presenting1.88290510
35MP0004808_abnormal_hematopoietic_stem1.88064994
36MP0000681_abnormal_thyroid_gland1.87911109
37MP0002398_abnormal_bone_marrow1.87087439
38MP0002723_abnormal_immune_serum1.84758498
39MP0003300_gastrointestinal_ulcer1.83329756
40MP0010352_gastrointestinal_tract_polyps1.80823187
41MP0002420_abnormal_adaptive_immunity1.73038545
42MP0001819_abnormal_immune_cell1.72780068
43MP0010155_abnormal_intestine_physiology1.71595744
44MP0004859_abnormal_synaptic_plasticity1.71301594
45MP0002419_abnormal_innate_immunity1.68486952
46MP0005671_abnormal_response_to1.67727305
47MP0005387_immune_system_phenotype1.66608077
48MP0001790_abnormal_immune_system1.66608077
49MP0003111_abnormal_nucleus_morphology1.66522200
50MP0002234_abnormal_pharynx_morphology1.66424144
51MP0000689_abnormal_spleen_morphology1.64706258
52MP0000716_abnormal_immune_system1.61864006
53MP0010307_abnormal_tumor_latency1.58793421
54MP0002405_respiratory_system_inflammati1.57569899
55MP0002722_abnormal_immune_system1.57302280
56MP0003191_abnormal_cellular_cholesterol1.52871286
57MP0002429_abnormal_blood_cell1.52738424
58MP0003122_maternal_imprinting1.50850875
59MP0004947_skin_inflammation1.50362112
60MP0003724_increased_susceptibility_to1.48517248
61MP0000465_gastrointestinal_hemorrhage1.48047424
62MP0000858_altered_metastatic_potential1.47465558
63MP0001873_stomach_inflammation1.45380325
64MP0001845_abnormal_inflammatory_respons1.44712051
65MP0003705_abnormal_hypodermis_morpholog1.42557948
66MP0005076_abnormal_cell_differentiation1.40910017
67MP0001533_abnormal_skeleton_physiology1.38981289
68MP0002148_abnormal_hypersensitivity_rea1.35562320
69MP0006054_spinal_hemorrhage1.35422978
70MP0003077_abnormal_cell_cycle1.34460862
71MP0008007_abnormal_cellular_replicative1.34193450
72MP0004957_abnormal_blastocyst_morpholog1.33951581
73MP0002166_altered_tumor_susceptibility1.32312770
74MP0000703_abnormal_thymus_morphology1.32244747
75MP0005058_abnormal_lysosome_morphology1.31679044
76MP0003172_abnormal_lysosome_physiology1.30986908
77MP0006082_CNS_inflammation1.29919672
78MP0004233_abnormal_muscle_weight1.29430394
79MP0005083_abnormal_biliary_tract1.28700756
80MP0003123_paternal_imprinting1.27853993
81MP0003878_abnormal_ear_physiology1.27282314
82MP0005377_hearing/vestibular/ear_phenot1.27282314
83MP0008469_abnormal_protein_level1.25636046
84MP0002019_abnormal_tumor_incidence1.25449091
85MP0003879_abnormal_hair_cell1.23053009
86MP0002877_abnormal_melanocyte_morpholog1.22266989
87MP0005023_abnormal_wound_healing1.21211045
88MP0005257_abnormal_intraocular_pressure1.19402589
89MP0000566_synostosis1.18412044
90MP0003315_abnormal_perineum_morphology1.18288904
91MP0005501_abnormal_skin_physiology1.17388332
92MP0001293_anophthalmia1.16789129
93MP0000604_amyloidosis1.16320457
94MP0001853_heart_inflammation1.15948381
95MP0009053_abnormal_anal_canal1.15066666
96MP0004185_abnormal_adipocyte_glucose1.14014203
97MP0002132_abnormal_respiratory_system1.12531270
98MP0003866_abnormal_defecation1.11657075
99MP0000747_muscle_weakness1.10439151
100MP0002092_abnormal_eye_morphology1.09373397
101MP0010094_abnormal_chromosome_stability1.07709568
102MP0005075_abnormal_melanosome_morpholog1.04890159
103MP0005365_abnormal_bile_salt1.03283486
104MP0003938_abnormal_ear_development1.01223218
105MP0005623_abnormal_meninges_morphology1.00683790
106MP0003566_abnormal_cell_adhesion1.00550027
107MP0008057_abnormal_DNA_replication1.00279760
108MP0002006_tumorigenesis1.00164807
109MP0000313_abnormal_cell_death1.00010455
110MP0005666_abnormal_adipose_tissue0.97994759
111MP0002933_joint_inflammation0.97183531
112MP0002822_catalepsy0.93329831
113MP0005375_adipose_tissue_phenotype0.89259980
114MP0000598_abnormal_liver_morphology0.88639596
115MP0000609_abnormal_liver_physiology0.88517242
116MP0000350_abnormal_cell_proliferation0.87450478
117MP0000003_abnormal_adipose_tissue0.87442163
118MP0005319_abnormal_enzyme/_coenzyme0.87274215
119MP0001727_abnormal_embryo_implantation0.86907651
120MP0003448_altered_tumor_morphology0.86644370
121MP0005670_abnormal_white_adipose0.85428652
122MP0003634_abnormal_glial_cell0.84262734
123MP0000477_abnormal_intestine_morphology0.83811766
124MP0000343_altered_response_to0.83213159
125MP0001270_distended_abdomen0.81722904
126MP0001849_ear_inflammation0.81713784
127MP0003453_abnormal_keratinocyte_physiol0.80891638
128MP0005174_abnormal_tail_pigmentation0.80618425
129MP0000751_myopathy0.79430834
130MP0001661_extended_life_span0.79315656
131MP0005310_abnormal_salivary_gland0.78439729
132MP0005390_skeleton_phenotype0.77677089
133MP0002089_abnormal_postnatal_growth/wei0.75080241
134MP0003075_altered_response_to0.74964308
135MP0001348_abnormal_lacrimal_gland0.74660894
136MP0003806_abnormal_nucleotide_metabolis0.74308266
137MP0003656_abnormal_erythrocyte_physiolo0.73879815
138MP0000613_abnormal_salivary_gland0.71433411
139MP0000759_abnormal_skeletal_muscle0.71285857
140MP0000026_abnormal_inner_ear0.70893079
141MP0000733_abnormal_muscle_development0.70598029
142MP0001346_abnormal_lacrimal_gland0.69670936
143MP0001730_embryonic_growth_arrest0.68840105
144MP0008058_abnormal_DNA_repair0.67801685
145MP0003943_abnormal_hepatobiliary_system0.67717963
146MP0002080_prenatal_lethality0.67585785
147MP0005193_abnormal_anterior_eye0.66967889
148MP0000358_abnormal_cell_content/0.66735027
149MP0000371_diluted_coat_color0.66596959
150MP0003186_abnormal_redox_activity0.66294390
151MP0005220_abnormal_exocrine_pancreas0.66111642
152MP0009764_decreased_sensitivity_to0.64351406
153MP0005621_abnormal_cell_physiology0.63899670
154MP0000537_abnormal_urethra_morphology0.63592375
155MP0003942_abnormal_urinary_system0.63360849
156MP0004510_myositis0.61949878
157MP0002098_abnormal_vibrissa_morphology0.60654407
158MP0008874_decreased_physiological_sensi0.59726564
159MP0000762_abnormal_tongue_morphology0.59638260
160MP0002697_abnormal_eye_size0.55615524
161MP0009931_abnormal_skin_appearance0.54587716
162MP0005423_abnormal_somatic_nervous0.53699459
163MP0006036_abnormal_mitochondrial_physio0.53171661
164MP0002116_abnormal_craniofacial_bone0.52186863
165MP0000778_abnormal_nervous_system0.51067495
166MP0008932_abnormal_embryonic_tissue0.50089661
167MP0006035_abnormal_mitochondrial_morpho0.49792080
168MP0000013_abnormal_adipose_tissue0.49087293
169MP0004133_heterotaxia0.46614899
170MP0001340_abnormal_eyelid_morphology0.46390640
171MP0005508_abnormal_skeleton_morphology0.44932178

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)4.10989522
2Nasal polyposis (HP:0100582)3.99349080
3Abnormality of glycolipid metabolism (HP:0010969)3.81544380
4Abnormality of liposaccharide metabolism (HP:0010968)3.81544380
5Abnormality of glycosphingolipid metabolism (HP:0004343)3.81544380
6Elevated erythrocyte sedimentation rate (HP:0003565)3.80945373
7Thrombocytosis (HP:0001894)3.74859791
8Chronic otitis media (HP:0000389)3.70087458
9Abnormality of the nasal mucosa (HP:0000433)3.69909888
10Petechiae (HP:0000967)3.52646045
11Recurrent abscess formation (HP:0002722)3.41689769
12Myositis (HP:0100614)3.30178111
13IgM deficiency (HP:0002850)3.26227547
14Aplasia/Hypoplasia of the sacrum (HP:0008517)3.23227449
15Achilles tendon contracture (HP:0001771)3.23155382
16Eczematoid dermatitis (HP:0000976)3.20328210
17Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)3.09674573
18Ragged-red muscle fibers (HP:0003200)3.09149393
19Gastrointestinal inflammation (HP:0004386)3.08183893
20Abnormal number of erythroid precursors (HP:0012131)3.03003107
21Thoracic kyphosis (HP:0002942)3.01919116
22Reticulocytosis (HP:0001923)2.99589185
23Abnormality of cells of the erythroid lineage (HP:0012130)2.98021218
24Annular pancreas (HP:0001734)2.92653633
25Inflammation of the large intestine (HP:0002037)2.89829036
26Abnormality of T cell physiology (HP:0011840)2.87280920
27Truncus arteriosus (HP:0001660)2.86005456
28Abnormality of the Achilles tendon (HP:0005109)2.82220915
29Pointed chin (HP:0000307)2.74570545
30Recurrent bacterial skin infections (HP:0005406)2.73981678
31Abnormal platelet function (HP:0011869)2.72478527
32Impaired platelet aggregation (HP:0003540)2.72478527
33Recurrent bronchitis (HP:0002837)2.72428034
34Cellulitis (HP:0100658)2.67395173
35Distal upper limb amyotrophy (HP:0007149)2.64570281
36Upper limb amyotrophy (HP:0009129)2.64570281
37Recurrent fungal infections (HP:0002841)2.63133611
38Prolonged bleeding time (HP:0003010)2.62709545
39Hyperthyroidism (HP:0000836)2.60251531
40Insomnia (HP:0100785)2.60172331
41Interstitial pulmonary disease (HP:0006530)2.59001357
42Hypertensive crisis (HP:0100735)2.56891540
43Broad distal phalanx of finger (HP:0009836)2.56791118
44Recurrent viral infections (HP:0004429)2.55854028
45Retinal dysplasia (HP:0007973)2.55541804
46Reticulocytopenia (HP:0001896)2.55458078
47Colitis (HP:0002583)2.54437319
48Abnormal delayed hypersensitivity skin test (HP:0002963)2.53134460
49Poikiloderma (HP:0001029)2.49958569
50Deep palmar crease (HP:0006191)2.47932888
51Protrusio acetabuli (HP:0003179)2.47619991
52Myopathic facies (HP:0002058)2.42682118
53Abnormality of macrophages (HP:0004311)2.38918971
54Orchitis (HP:0100796)2.38796596
55Epistaxis (HP:0000421)2.37342612
56Increased cerebral lipofuscin (HP:0011813)2.37157213
57Prolonged neonatal jaundice (HP:0006579)2.36730484
58Cheilitis (HP:0100825)2.30137009
59Mediastinal lymphadenopathy (HP:0100721)2.29470713
60Absent epiphyses (HP:0010577)2.29386480
61Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.29386480
62Urinary glycosaminoglycan excretion (HP:0003541)2.28876717
63Mucopolysacchariduria (HP:0008155)2.28876717
64J-shaped sella turcica (HP:0002680)2.28589667
65Ulnar bowing (HP:0003031)2.26309744
66Hypoplasia of the capital femoral epiphysis (HP:0003090)2.26012888
67Increased muscle lipid content (HP:0009058)2.25442711
68Flattened epiphyses (HP:0003071)2.24955213
69Cervical subluxation (HP:0003308)2.24470635
70Abnormality of the aortic arch (HP:0012303)2.24054009
71Increased neuronal autofluorescent lipopigment (HP:0002074)2.23128727
72Recurrent gram-negative bacterial infections (HP:0005420)2.21220471
73Vertebral compression fractures (HP:0002953)2.20950772
74Long palpebral fissure (HP:0000637)2.19585370
75Cerebral aneurysm (HP:0004944)2.18823844
76Abnormality of T cells (HP:0002843)2.18121870
77Aplastic anemia (HP:0001915)2.17374136
78Progressive muscle weakness (HP:0003323)2.17107647
79Increased intramyocellular lipid droplets (HP:0012240)2.16997553
80Dysostosis multiplex (HP:0000943)2.16797448
81Meningitis (HP:0001287)2.16788094
82Centrally nucleated skeletal muscle fibers (HP:0003687)2.15522195
83Abnormality of polysaccharide metabolism (HP:0011012)2.15252564
84Abnormality of glycosaminoglycan metabolism (HP:0004371)2.15252564
85Abnormality of mucopolysaccharide metabolism (HP:0011020)2.15252564
86Nonimmune hydrops fetalis (HP:0001790)2.13985233
87Abnormal gallbladder physiology (HP:0012438)2.13152381
88Cholecystitis (HP:0001082)2.13152381
89Rib fusion (HP:0000902)2.11367888
90High anterior hairline (HP:0009890)2.11107374
91Hyperacusis (HP:0010780)2.10476979
92Albinism (HP:0001022)2.10085561
93Arterial thrombosis (HP:0004420)2.09299743
94Urticaria (HP:0001025)2.07422935
95Polycythemia (HP:0001901)2.06740923
96Elfin facies (HP:0004428)2.06575740
97Gingival bleeding (HP:0000225)2.06520761
98Hypercortisolism (HP:0001578)2.05925864
99Recurrent skin infections (HP:0001581)2.05838650
100Microvesicular hepatic steatosis (HP:0001414)2.05152216
101Short femoral neck (HP:0100864)2.04663514
102Abnormal number of incisors (HP:0011064)2.04116456
103Athetosis (HP:0002305)2.02578344
104Autoimmune thrombocytopenia (HP:0001973)2.01789930
105Distal lower limb amyotrophy (HP:0008944)2.01724974
106Increased density of long bones (HP:0006392)2.01361856
107Increased serum ferritin (HP:0003281)2.01147636
108Loss of speech (HP:0002371)2.00893748
109Down-sloping shoulders (HP:0200021)1.99843551
110Stridor (HP:0010307)1.99254145
111Pallor (HP:0000980)1.98795675
112Nuclear cataract (HP:0100018)1.98575023
113Overriding aorta (HP:0002623)1.97758962
114Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.97052148
115Vacuolated lymphocytes (HP:0001922)1.96527478
116Joint stiffness (HP:0001387)1.96466925
117Mitral regurgitation (HP:0001653)1.96351794
118Tetraparesis (HP:0002273)1.95318640
119Abnormality of the phalanges of the hallux (HP:0010057)1.94583726
120Bowing of the arm (HP:0006488)1.93366522
121Bowed forearm bones (HP:0003956)1.93366522
122Vasculitis (HP:0002633)1.93075985
123Ankle clonus (HP:0011448)1.92317502
124Axonal loss (HP:0003447)1.91849199
125Short nail (HP:0001799)1.91191006
126Fatigue (HP:0012378)1.91070477
127Periodontitis (HP:0000704)1.90406488
128Radial bowing (HP:0002986)1.90012715
129Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.87576880
130Emphysema (HP:0002097)1.87320050
131Selective tooth agenesis (HP:0001592)1.84799737
132Bronchitis (HP:0012387)1.84568740
133Panhypogammaglobulinemia (HP:0003139)1.84250062
134Increased IgE level (HP:0003212)1.84177259
135Testicular atrophy (HP:0000029)1.84156351
136Back pain (HP:0003418)1.83385262
137Atelectasis (HP:0100750)1.82656144
138Trismus (HP:0000211)1.82151684
139Retrobulbar optic neuritis (HP:0100654)1.82114873
140Optic neuritis (HP:0100653)1.82114873
141Bulbar palsy (HP:0001283)1.81705789
142Hypoparathyroidism (HP:0000829)1.81036697
143Microretrognathia (HP:0000308)1.80941925
144Breast hypoplasia (HP:0003187)1.80822729
145Macrocytic anemia (HP:0001972)1.80613260
146Multiple enchondromatosis (HP:0005701)1.80215978
147Renal duplication (HP:0000075)1.79198528
148Natal tooth (HP:0000695)1.78313128
149Abnormality of the thoracic spine (HP:0100711)1.77767113
150Hyperparathyroidism (HP:0000843)1.75363623
151Growth hormone excess (HP:0000845)1.74928051
152Polygenic inheritance (HP:0010982)1.74715424
153Hypochromic anemia (HP:0001931)1.74068838
154Myocardial infarction (HP:0001658)1.73516997
155Purpura (HP:0000979)1.72872403
156Increased connective tissue (HP:0009025)1.72419777
157Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.71187147
158Increased IgM level (HP:0003496)1.70688518
159Skin ulcer (HP:0200042)1.69061846
160Chest pain (HP:0100749)1.69005528
161Abnormality of reticulocytes (HP:0004312)1.68110364
162Patellar dislocation (HP:0002999)1.68109048
163Hypercalcemia (HP:0003072)1.67896914
164Hemorrhage of the eye (HP:0011885)1.67887545
165Segmental peripheral demyelination/remyelination (HP:0003481)1.67561673
166Slender long bone (HP:0003100)1.65641941
167Hematochezia (HP:0002573)1.65411120
168Entropion (HP:0000621)1.64580504
169Hand muscle atrophy (HP:0009130)1.63455321
170Progressive neurologic deterioration (HP:0002344)1.62063979
171Spontaneous hematomas (HP:0007420)1.61843714
172Pulmonary infiltrates (HP:0002113)1.59751549
173Obstructive lung disease (HP:0006536)1.59570160
174Chronic obstructive pulmonary disease (HP:0006510)1.59570160
175Abnormality of iron homeostasis (HP:0011031)1.58728772
176Hypergammaglobulinemia (HP:0010702)1.57257616

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.65642309
2ERN13.58974258
3TRIB33.47782096
4EEF2K3.32458825
5PRPF4B2.63541361
6MAP3K102.50392246
7PKN22.46706678
8NME22.34045207
9ARAF2.30024692
10BLK2.28906752
11SMG12.17836432
12PRKD32.16867928
13WNK42.14838365
14FLT32.08835446
15NEK22.03846355
16EPHB22.01803509
17PIM21.95041824
18ZAP701.93332424
19TBK11.89878887
20BTK1.70030637
21KIT1.67333901
22BCKDK1.58261924
23MARK21.57882107
24LRRK21.57072079
25SCYL21.55614182
26SIK11.53346139
27CSF1R1.51100028
28DYRK31.50156648
29KDR1.49932329
30RPS6KA41.49309184
31MAP3K111.45088652
32JAK31.40920542
33MAPKAPK31.36160009
34PAK41.35891995
35STK101.33525956
36CDK121.32446396
37TEC1.30978736
38TYK21.28969023
39IKBKE1.28814139
40BMX1.27194471
41PRKD21.24979655
42TESK11.21251138
43BRSK11.21035739
44STK391.21005729
45MAP2K31.20822566
46TESK21.17723679
47BRAF1.15941806
48PIM11.15523485
49IKBKB1.14457636
50AURKA1.13589785
51LIMK11.10909533
52RPS6KB21.09891084
53SIK21.07790164
54CDK81.05821577
55PTK61.04794609
56MAP2K71.03260723
57TXK1.00179584
58CDK41.00168331
59GRK60.98211204
60MAP3K10.94483372
61TGFBR10.93992245
62MATK0.93819649
63BUB10.92794920
64RIPK10.92397038
65SYK0.91014544
66IRAK20.88208350
67TAOK10.87846815
68CSK0.87140292
69CDK70.87068740
70STK160.85433065
71ICK0.83281474
72TTN0.83074603
73PASK0.82397041
74TYRO30.81942391
75VRK20.80591512
76ABL20.78343468
77TGFBR20.78333563
78CHUK0.76402749
79MAP3K80.76129403
80HCK0.74857683
81RPS6KA20.74600556
82MOS0.74447908
83MAPK110.74434663
84CDK11A0.74431349
85MARK30.71767514
86CAMKK10.70793210
87LYN0.68864501
88KSR20.66662414
89IRAK30.66337554
90DYRK1B0.65786726
91NTRK10.65472300
92CSNK1G30.64389368
93DAPK30.64034339
94SIK30.63646065
95IRAK40.63623587
96PRKG20.63359935
97FGFR40.62407516
98MAPK150.60939294
99MAP3K140.60686288
100ATR0.60678785
101LCK0.60120200
102TAOK20.59966640
103CDK150.59886480
104RPS6KA60.58243030
105EPHA20.57353657
106MAP3K60.56744211
107CDK140.54733239
108ITK0.54305488
109RPS6KL10.54170240
110RPS6KC10.54170240
111HIPK20.53716088
112DAPK10.53518268
113CDK180.53438597
114CDK190.53393389
115JAK20.53295916
116JAK10.53153331
117CDC70.52926319
118DDR20.52756711
119CDK60.51889462
120MAPKAPK20.51808483
121TAOK30.51388743
122MAP3K70.49593751
123TRIM280.49581356
124AKT20.49360661
125CLK10.48893123
126PLK10.47801799
127ILK0.47775152
128EPHB10.46969037
129LMTK20.46289662
130MTOR0.46219358
131AURKB0.45923180
132DYRK20.45866027
133ALK0.45457302
134NEK10.45093951
135MAP2K20.44507253
136TNK20.44420668
137PDPK10.44105967
138NME10.43947398
139CDC42BPA0.43414285
140PAK20.43067266
141CSNK1A1L0.42505771
142PAK10.40666684
143WEE10.40611161
144RPS6KA50.39925178
145ACVR1B0.39479681
146CAMK1D0.39464582
147MAP2K40.38251553
148KSR10.37184058
149RPS6KA10.34697719
150CSNK1G20.32622084
151PRKCI0.31896185
152PTK20.31694055
153CAMK2G0.28302950

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030302.89265954
2Ribosome_Homo sapiens_hsa030102.26852582
3Base excision repair_Homo sapiens_hsa034102.24602501
4Sulfur relay system_Homo sapiens_hsa041221.98227858
5Primary immunodeficiency_Homo sapiens_hsa053401.93941194
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.90193547
7Leishmaniasis_Homo sapiens_hsa051401.84260042
8Prion diseases_Homo sapiens_hsa050201.83593358
9Legionellosis_Homo sapiens_hsa051341.81991139
10One carbon pool by folate_Homo sapiens_hsa006701.79674631
11Other glycan degradation_Homo sapiens_hsa005111.73132322
12B cell receptor signaling pathway_Homo sapiens_hsa046621.63885954
13Mismatch repair_Homo sapiens_hsa034301.63031318
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59362171
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.57636555
16NF-kappa B signaling pathway_Homo sapiens_hsa040641.57180115
17Folate biosynthesis_Homo sapiens_hsa007901.56955786
18Acute myeloid leukemia_Homo sapiens_hsa052211.55481179
19Measles_Homo sapiens_hsa051621.51723089
20Vibrio cholerae infection_Homo sapiens_hsa051101.51268942
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.51103077
22Antigen processing and presentation_Homo sapiens_hsa046121.50597071
23Carbon metabolism_Homo sapiens_hsa012001.49398347
24Glycosaminoglycan degradation_Homo sapiens_hsa005311.48055231
25Herpes simplex infection_Homo sapiens_hsa051681.47051416
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.41847097
27Pentose phosphate pathway_Homo sapiens_hsa000301.40943165
28Apoptosis_Homo sapiens_hsa042101.38174102
29Shigellosis_Homo sapiens_hsa051311.36355619
30Spliceosome_Homo sapiens_hsa030401.33489475
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.32089779
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.31073707
33Intestinal immune network for IgA production_Homo sapiens_hsa046721.27314856
34Osteoclast differentiation_Homo sapiens_hsa043801.27217146
35Chronic myeloid leukemia_Homo sapiens_hsa052201.26654085
36Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.24596284
37Cyanoamino acid metabolism_Homo sapiens_hsa004601.23691647
38Toll-like receptor signaling pathway_Homo sapiens_hsa046201.22118489
39Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.20664181
40Hematopoietic cell lineage_Homo sapiens_hsa046401.20620177
41Selenocompound metabolism_Homo sapiens_hsa004501.19457974
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.17269798
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16336384
44Pyrimidine metabolism_Homo sapiens_hsa002401.14939749
45p53 signaling pathway_Homo sapiens_hsa041151.14904894
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.11585876
47Viral carcinogenesis_Homo sapiens_hsa052031.10605087
48Jak-STAT signaling pathway_Homo sapiens_hsa046301.10502386
49Arginine and proline metabolism_Homo sapiens_hsa003301.10434442
50Malaria_Homo sapiens_hsa051441.10101971
51Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09838726
52Influenza A_Homo sapiens_hsa051641.09569984
53Toxoplasmosis_Homo sapiens_hsa051451.09097631
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.08857023
55Staphylococcus aureus infection_Homo sapiens_hsa051501.08630818
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08083105
57Hepatitis B_Homo sapiens_hsa051611.07782041
58Fructose and mannose metabolism_Homo sapiens_hsa000511.06970411
59Endocytosis_Homo sapiens_hsa041441.05252787
60Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04269918
61RNA transport_Homo sapiens_hsa030131.04223878
62Small cell lung cancer_Homo sapiens_hsa052221.04166760
63Cell cycle_Homo sapiens_hsa041101.01186857
64AMPK signaling pathway_Homo sapiens_hsa041521.00321967
65Synaptic vesicle cycle_Homo sapiens_hsa047210.96808653
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.94117660
67Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.92585877
68Tuberculosis_Homo sapiens_hsa051520.91982576
69TNF signaling pathway_Homo sapiens_hsa046680.91765112
70Biosynthesis of amino acids_Homo sapiens_hsa012300.91679444
71Galactose metabolism_Homo sapiens_hsa000520.88904195
72Epstein-Barr virus infection_Homo sapiens_hsa051690.87844313
73Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.86758445
74N-Glycan biosynthesis_Homo sapiens_hsa005100.86671099
75HTLV-I infection_Homo sapiens_hsa051660.83898609
76Homologous recombination_Homo sapiens_hsa034400.83813430
77Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.82291412
78Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82099488
79Pertussis_Homo sapiens_hsa051330.81197968
80Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.80634574
81Insulin signaling pathway_Homo sapiens_hsa049100.79055033
82AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78644034
83Bladder cancer_Homo sapiens_hsa052190.78634711
84Fatty acid elongation_Homo sapiens_hsa000620.78082090
85Central carbon metabolism in cancer_Homo sapiens_hsa052300.76760705
86Leukocyte transendothelial migration_Homo sapiens_hsa046700.76579161
87Lysosome_Homo sapiens_hsa041420.75304071
88ErbB signaling pathway_Homo sapiens_hsa040120.75266440
89Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.74105675
90Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.73545655
91Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.72677210
92T cell receptor signaling pathway_Homo sapiens_hsa046600.72071791
93Nucleotide excision repair_Homo sapiens_hsa034200.70749370
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.70557460
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70354266
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69694142
97Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69478729
98HIF-1 signaling pathway_Homo sapiens_hsa040660.69183736
99Caffeine metabolism_Homo sapiens_hsa002320.68162385
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68111256
101Pancreatic cancer_Homo sapiens_hsa052120.67910990
102Notch signaling pathway_Homo sapiens_hsa043300.67582401
103Insulin resistance_Homo sapiens_hsa049310.65535926
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.64731923
105Salmonella infection_Homo sapiens_hsa051320.63396799
106Renal cell carcinoma_Homo sapiens_hsa052110.63002826
107Systemic lupus erythematosus_Homo sapiens_hsa053220.62521855
108Pentose and glucuronate interconversions_Homo sapiens_hsa000400.62048189
109Longevity regulating pathway - mammal_Homo sapiens_hsa042110.61576476
110Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60628598
111Basal cell carcinoma_Homo sapiens_hsa052170.60269483
112Collecting duct acid secretion_Homo sapiens_hsa049660.59283701
113Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58070258
114Hedgehog signaling pathway_Homo sapiens_hsa043400.57660944
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.57660298
116Endometrial cancer_Homo sapiens_hsa052130.57220923
117Thyroid cancer_Homo sapiens_hsa052160.56328540
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56189763
119Phagosome_Homo sapiens_hsa041450.55231334
120Parkinsons disease_Homo sapiens_hsa050120.55089357
121Non-small cell lung cancer_Homo sapiens_hsa052230.53802622
122Phenylalanine metabolism_Homo sapiens_hsa003600.53768876
123Platelet activation_Homo sapiens_hsa046110.53414394
124Viral myocarditis_Homo sapiens_hsa054160.53310229
125Steroid biosynthesis_Homo sapiens_hsa001000.52895584
126Hepatitis C_Homo sapiens_hsa051600.52454539
127mTOR signaling pathway_Homo sapiens_hsa041500.51144474
128Neurotrophin signaling pathway_Homo sapiens_hsa047220.50564288
129Amoebiasis_Homo sapiens_hsa051460.50031719
130VEGF signaling pathway_Homo sapiens_hsa043700.47874903
131Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47757528
132Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46840689
133Glioma_Homo sapiens_hsa052140.46648334
134Prolactin signaling pathway_Homo sapiens_hsa049170.46589000
135Glutathione metabolism_Homo sapiens_hsa004800.46263774
136Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45715452
137Oxidative phosphorylation_Homo sapiens_hsa001900.45235020
138Vitamin digestion and absorption_Homo sapiens_hsa049770.45016601
139Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.41386125
140Huntingtons disease_Homo sapiens_hsa050160.41279438
141Alcoholism_Homo sapiens_hsa050340.41100062
142Colorectal cancer_Homo sapiens_hsa052100.32042286
143Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31378876

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