NFRKB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1spliceosomal tri-snRNP complex assembly (GO:0000244)5.58146036
2hyperosmotic salinity response (GO:0042538)5.20430523
3hypotonic response (GO:0006971)4.42614088
4regulation of response to osmotic stress (GO:0047484)4.42605955
5regulation of RNA export from nucleus (GO:0046831)4.37180089
6positive regulation of gamma-delta T cell activation (GO:0046645)4.31826658
7histone H3-K4 trimethylation (GO:0080182)4.16205875
8mitotic sister chromatid segregation (GO:0000070)3.94433042
9pteridine-containing compound biosynthetic process (GO:0042559)3.92499203
10histone-serine phosphorylation (GO:0035404)3.86996517
11DNA unwinding involved in DNA replication (GO:0006268)3.79559668
12negative regulation of histone methylation (GO:0031061)3.62085700
13nuclear envelope disassembly (GO:0051081)3.60829138
14membrane disassembly (GO:0030397)3.60829138
15regulation of histone H3-K9 methylation (GO:0051570)3.56758013
16regulation of NFAT protein import into nucleus (GO:0051532)3.50664158
17ncRNA catabolic process (GO:0034661)3.50057942
18V(D)J recombination (GO:0033151)3.47262576
19positive T cell selection (GO:0043368)3.46723904
20regulation of gamma-delta T cell differentiation (GO:0045586)3.46453866
21histone H3-K4 methylation (GO:0051568)3.43303756
22meiotic chromosome segregation (GO:0045132)3.40056728
23formation of translation preinitiation complex (GO:0001731)3.39474359
24negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.39397479
25regulation of nucleobase-containing compound transport (GO:0032239)3.38027451
26peptidyl-lysine trimethylation (GO:0018023)3.37811628
27nuclear pore complex assembly (GO:0051292)3.36351317
28spliceosomal snRNP assembly (GO:0000387)3.34128930
29regulation of gamma-delta T cell activation (GO:0046643)3.30407941
30negative regulation of cell cycle G2/M phase transition (GO:1902750)3.29968255
31negative T cell selection (GO:0043383)3.26326321
32mitotic chromosome condensation (GO:0007076)3.22065004
33positive thymic T cell selection (GO:0045059)3.20181300
34meiotic cell cycle (GO:0051321)3.20164803
35histone H3-K9 methylation (GO:0051567)3.19130896
36regulation of spindle organization (GO:0090224)3.18741097
37DNA strand elongation involved in DNA replication (GO:0006271)3.16898696
38negative regulation of mRNA processing (GO:0050686)3.16176133
39positive regulation of gene expression, epigenetic (GO:0045815)3.14736862
40DNA strand elongation (GO:0022616)3.09556273
41DNA replication initiation (GO:0006270)3.07705447
42interferon-gamma production (GO:0032609)3.07333263
43mitotic metaphase plate congression (GO:0007080)3.06964835
44negative regulation of mRNA metabolic process (GO:1903312)3.06362372
45regulation of histone H3-K27 methylation (GO:0061085)3.04041835
46histone H4-K12 acetylation (GO:0043983)3.03939159
47histone H3-K36 demethylation (GO:0070544)3.03298273
48nuclear pore organization (GO:0006999)3.02824193
49regulation of nuclear cell cycle DNA replication (GO:0033262)3.02525994
50DNA replication checkpoint (GO:0000076)3.02475516
51N-terminal protein amino acid acetylation (GO:0006474)2.99912155
52resolution of meiotic recombination intermediates (GO:0000712)2.99891270
53mitotic sister chromatid cohesion (GO:0007064)2.99314511
54histone mRNA metabolic process (GO:0008334)2.97451569
55negative regulation of RNA splicing (GO:0033119)2.97260990
56DNA methylation involved in gamete generation (GO:0043046)2.96607256
57negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.95921979
58negative regulation of cell killing (GO:0031342)2.95921979
59T cell selection (GO:0045058)2.94571108
60regulation of telomere maintenance via telomerase (GO:0032210)2.93990824
61negative thymic T cell selection (GO:0045060)2.91656234
62DNA synthesis involved in DNA repair (GO:0000731)2.90824992
63regulation of sister chromatid cohesion (GO:0007063)2.90702630
64histone H3-K9 modification (GO:0061647)2.90567825
65post-embryonic morphogenesis (GO:0009886)2.90425270
66cellular response to interleukin-15 (GO:0071350)2.89217582
67stress granule assembly (GO:0034063)2.89101124
68histone lysine methylation (GO:0034968)2.88497478
69attachment of spindle microtubules to kinetochore (GO:0008608)2.88096674
70DNA alkylation (GO:0006305)2.87160176
71DNA methylation (GO:0006306)2.87160176
72heterochromatin organization (GO:0070828)2.86806073
73microtubule polymerization or depolymerization (GO:0031109)2.85910184
74regulation of histone methylation (GO:0031060)2.85870773
75regulation of mitotic spindle organization (GO:0060236)2.85400678
76negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.85213471
77negative regulation of translation, ncRNA-mediated (GO:0040033)2.85213471
78regulation of translation, ncRNA-mediated (GO:0045974)2.85213471
79negative regulation of chromosome segregation (GO:0051985)2.84676787
80negative regulation of DNA-dependent DNA replication (GO:2000104)2.84560468
81positive regulation of granulocyte differentiation (GO:0030854)2.83976895
82nuclear envelope organization (GO:0006998)2.82990216
83base-excision repair (GO:0006284)2.81488883
84pore complex assembly (GO:0046931)2.80852819
85ribosomal small subunit assembly (GO:0000028)2.80657976
86mRNA transport (GO:0051028)2.80422869
87regulation of chromatin silencing (GO:0031935)2.80134153
88peptidyl-lysine dimethylation (GO:0018027)2.79578382
89gene silencing by RNA (GO:0031047)2.79578126
90response to interleukin-15 (GO:0070672)2.79475318
91metaphase plate congression (GO:0051310)2.79136899
92telomere maintenance via semi-conservative replication (GO:0032201)2.78525155
93chromosome segregation (GO:0007059)2.77210243
94negative regulation of DNA repair (GO:0045738)2.76024836
95spindle checkpoint (GO:0031577)2.75447876
96chromosome condensation (GO:0030261)2.74071663
97DNA topological change (GO:0006265)2.73841790
98peptidyl-lysine methylation (GO:0018022)2.73285524
99mRNA splice site selection (GO:0006376)2.70836095
100mitotic spindle checkpoint (GO:0071174)2.70609348
101regulation of DNA endoreduplication (GO:0032875)2.70548027
102regulation of chromatin binding (GO:0035561)2.70312054
103maturation of SSU-rRNA (GO:0030490)2.69669416
104regulation of translational fidelity (GO:0006450)2.68981794
105mitotic spindle assembly checkpoint (GO:0007094)2.68051666
106cytoplasmic mRNA processing body assembly (GO:0033962)2.67501675
107activated T cell proliferation (GO:0050798)2.67109911
108regulation of histone H3-K4 methylation (GO:0051569)2.66133175
109histone H4 acetylation (GO:0043967)2.66044608
110negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.65356675
111negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.65356675
112negative regulation of mitotic sister chromatid segregation (GO:0033048)2.65356675
113negative regulation of mitotic sister chromatid separation (GO:2000816)2.65356675
114negative regulation of sister chromatid segregation (GO:0033046)2.65356675
115vascular smooth muscle contraction (GO:0014829)2.64681019
116ribosomal small subunit biogenesis (GO:0042274)2.64590966
117thymic T cell selection (GO:0045061)2.63667875
118spindle assembly checkpoint (GO:0071173)2.63053925
119B cell receptor signaling pathway (GO:0050853)2.63032516
120DNA conformation change (GO:0071103)2.61582325
121histone H2A acetylation (GO:0043968)2.60203998
122regulation of telomere maintenance (GO:0032204)2.59867632
123histone phosphorylation (GO:0016572)2.59546179
124protein localization to kinetochore (GO:0034501)2.59375676
125positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.58978923
126histone H3-K9 demethylation (GO:0033169)2.58874800
127histone demethylation (GO:0016577)2.58158350
128histone lysine demethylation (GO:0070076)2.58152401
129negative regulation of telomere maintenance (GO:0032205)2.57565249
130regulation of chromosome segregation (GO:0051983)2.57108911
131entrainment of circadian clock (GO:0009649)2.56231330
132regulation of regulatory T cell differentiation (GO:0045589)2.55776429
133chromatin assembly or disassembly (GO:0006333)2.55642314
134chromatin assembly (GO:0031497)2.55163522
135kinetochore organization (GO:0051383)2.55006598
136protein K6-linked ubiquitination (GO:0085020)2.54881460
137DNA damage induced protein phosphorylation (GO:0006975)2.54566622
138histone methylation (GO:0016571)2.54160020
139histone H4-K16 acetylation (GO:0043984)2.54132985
140T cell receptor signaling pathway (GO:0050852)2.53291186
141centriole replication (GO:0007099)2.53249629
142histone deubiquitination (GO:0016578)2.50749999
143DNA methylation or demethylation (GO:0044728)2.50248775
144histone mRNA catabolic process (GO:0071044)2.50018380
145positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.49277575
146monoubiquitinated protein deubiquitination (GO:0035520)2.48678023
147positive regulation of B cell differentiation (GO:0045579)2.48359385
148sister chromatid segregation (GO:0000819)2.46409514
149positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.46123011
150microtubule depolymerization (GO:0007019)2.46052370
151piRNA metabolic process (GO:0034587)2.45765005
152antigen receptor-mediated signaling pathway (GO:0050851)2.45457572
153protein localization to chromosome, centromeric region (GO:0071459)2.44869914
154DNA replication-independent nucleosome organization (GO:0034724)2.44053079
155DNA replication-independent nucleosome assembly (GO:0006336)2.44053079
156negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.43046224
157somatic diversification of immune receptors via germline recombination within a single locus (GO:0002.42923853
158somatic cell DNA recombination (GO:0016444)2.42923853
159mitotic nuclear envelope disassembly (GO:0007077)2.41940906
160DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.40278611
161DNA geometric change (GO:0032392)2.40197584
162positive regulation of cell cycle checkpoint (GO:1901978)2.40179724
163T cell homeostasis (GO:0043029)2.40002130
164positive regulation of histone methylation (GO:0031062)2.39881917
165DNA duplex unwinding (GO:0032508)2.39541597
166positive regulation of histone H3-K4 methylation (GO:0051571)2.39350307
167sister chromatid cohesion (GO:0007062)2.39013837
168pre-miRNA processing (GO:0031054)2.38896113
169histone H4-K5 acetylation (GO:0043981)2.38272947
170histone H4-K8 acetylation (GO:0043982)2.38272947

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.23235856
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.52880408
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.63814034
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.53758277
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.19453210
6TP63_19390658_ChIP-ChIP_HaCaT_Human3.11817288
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.86198154
8CIITA_25753668_ChIP-Seq_RAJI_Human2.77972508
9* MYC_22102868_ChIP-Seq_BL_Human2.73668532
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.51553998
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.43724650
12* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.38701036
13FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.32969677
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.25094807
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.15976186
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.11565807
17IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.10288838
18YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.09363119
19* AR_21909140_ChIP-Seq_LNCAP_Human2.09134002
20SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.99533448
21ELF1_17652178_ChIP-ChIP_JURKAT_Human1.98036808
22ZFX_18555785_ChIP-Seq_MESCs_Mouse1.98008394
23CREB1_15753290_ChIP-ChIP_HEK293T_Human1.97476886
24* SALL1_21062744_ChIP-ChIP_HESCs_Human1.89260402
25MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88662376
26CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.86302859
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.86061137
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.85073002
29JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.83754584
30MYB_26560356_Chip-Seq_TH1_Human1.78582934
31PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.78513759
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.75679900
33* RUNX_20019798_ChIP-Seq_JUKART_Human1.75386579
34MYB_26560356_Chip-Seq_TH2_Human1.72231214
35GABP_19822575_ChIP-Seq_HepG2_Human1.72088331
36RBPJ_22232070_ChIP-Seq_NCS_Mouse1.68993048
37FOXP3_21729870_ChIP-Seq_TREG_Human1.65370065
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.64742690
39* UTX_26944678_Chip-Seq_JUKART_Human1.64299799
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.64258109
41VDR_23849224_ChIP-Seq_CD4+_Human1.64043961
42VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.62291438
43MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.61899948
44DCP1A_22483619_ChIP-Seq_HELA_Human1.60514429
45DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.59776040
46DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.58533804
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.57789488
48BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.54150173
49IRF8_22096565_ChIP-ChIP_GC-B_Human1.54027181
50EGR1_19374776_ChIP-ChIP_THP-1_Human1.53473703
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.50787017
52VDR_21846776_ChIP-Seq_THP-1_Human1.50407654
53* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50131993
54ESR1_15608294_ChIP-ChIP_MCF-7_Human1.49873224
55CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.46972471
56* CHD1_26751641_Chip-Seq_LNCaP_Human1.44950182
57E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42260726
58HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.41704300
59SCL_19346495_ChIP-Seq_HPC-7_Human1.41215925
60* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.40581536
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.39621127
62TCF7_22412390_ChIP-Seq_EML_Mouse1.38755767
63* MAF_26560356_Chip-Seq_TH1_Human1.36165028
64* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.32683516
65* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.32497049
66* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30169369
67RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.29280117
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.26966000
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.26763241
70TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26383259
71KDM5A_27292631_Chip-Seq_BREAST_Human1.26369761
72SPI1_23547873_ChIP-Seq_NB4_Human1.23961657
73NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.23243611
74ZNF263_19887448_ChIP-Seq_K562_Human1.23167045
75* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.22658400
76MYCN_18555785_ChIP-Seq_MESCs_Mouse1.22577326
77ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22569482
78MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19298654
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19268763
80STAT4_19710469_ChIP-ChIP_TH1__Mouse1.18554171
81MYC_19079543_ChIP-ChIP_MESCs_Mouse1.17983289
82ELK1_19687146_ChIP-ChIP_HELA_Human1.17824060
83TFEB_21752829_ChIP-Seq_HELA_Human1.16641520
84HOXB4_20404135_ChIP-ChIP_EML_Mouse1.15175359
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.11506672
86MYC_18555785_ChIP-Seq_MESCs_Mouse1.10896017
87STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09728421
88NANOG_21062744_ChIP-ChIP_HESCs_Human1.09716984
89EWS_26573619_Chip-Seq_HEK293_Human1.08474393
90BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08399405
91PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07324528
92POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06283189
93TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05411492
94NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04682195
95MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04131644
96RUNX1_22412390_ChIP-Seq_EML_Mouse1.03792722
97KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.02583976
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02367124
99CLOCK_20551151_ChIP-Seq_293T_Human1.01737480
100MAF_26560356_Chip-Seq_TH2_Human1.00860160
101GATA3_27048872_Chip-Seq_THYMUS_Human1.00532959
102FLI1_27457419_Chip-Seq_LIVER_Mouse0.99718470
103PKCTHETA_26484144_Chip-Seq_BREAST_Human0.99557789
104KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99226421
105KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99226421
106KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99226421
107CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99218067
108ETS1_20019798_ChIP-Seq_JURKAT_Human0.98249949
109VDR_24763502_ChIP-Seq_THP-1_Human0.97193829
110GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96904878
111FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96416790
112LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95137433
113FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94888874
114GATA1_26923725_Chip-Seq_HPCs_Mouse0.94187609
115POU5F1_16153702_ChIP-ChIP_HESCs_Human0.92655481
116HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.92391576
117* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92308852
118NCOR1_26117541_ChIP-Seq_K562_Human0.91188466
119ATF3_27146783_Chip-Seq_COLON_Human0.91145532
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.91041119
121TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90957126
122HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.90376680
123TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.90201244
124FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.88662130
125E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.87852607
126CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87731662
127* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.87599339
128E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.87253192
129PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86747797
130GATA1_22025678_ChIP-Seq_K562_Human0.86617432
131GATA6_25053715_ChIP-Seq_YYC3_Human0.86574743
132POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.86445181
133TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86445181
134GABP_17652178_ChIP-ChIP_JURKAT_Human0.85850146
135ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.85089911
136TTF2_22483619_ChIP-Seq_HELA_Human0.83879485
137IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.83774423
138PCGF2_27294783_Chip-Seq_NPCs_Mouse0.83394098
139PCGF2_27294783_Chip-Seq_ESCs_Mouse0.82825998
140POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.82761536
141NANOG_18555785_ChIP-Seq_MESCs_Mouse0.82688527
142KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.79791925
143SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.78291854
144XRN2_22483619_ChIP-Seq_HELA_Human0.77459202
145SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.76373396

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.61874925
2MP0003763_abnormal_thymus_physiology3.11013992
3MP0010094_abnormal_chromosome_stability3.05230193
4MP0003111_abnormal_nucleus_morphology2.96179091
5MP0008057_abnormal_DNA_replication2.92809151
6MP0008877_abnormal_DNA_methylation2.73145155
7MP0008058_abnormal_DNA_repair2.70528431
8MP0003077_abnormal_cell_cycle2.57618694
9MP0003693_abnormal_embryo_hatching2.47825458
10MP0010030_abnormal_orbit_morphology2.38761711
11MP0002396_abnormal_hematopoietic_system2.36915469
12MP0000537_abnormal_urethra_morphology2.26767897
13MP0008260_abnormal_autophagy2.25251386
14MP0003787_abnormal_imprinting2.19099424
15MP0005671_abnormal_response_to2.18923763
16MP0000703_abnormal_thymus_morphology2.18278568
17MP0006292_abnormal_olfactory_placode2.13603775
18MP0004808_abnormal_hematopoietic_stem2.11972480
19MP0001800_abnormal_humoral_immune2.02747049
20MP0002398_abnormal_bone_marrow1.99897748
21MP0010234_abnormal_vibrissa_follicle1.98337818
22MP0008007_abnormal_cellular_replicative1.97812636
23MP0000015_abnormal_ear_pigmentation1.91196843
24MP0004264_abnormal_extraembryonic_tissu1.85448432
25MP0001346_abnormal_lacrimal_gland1.83496139
26MP0005174_abnormal_tail_pigmentation1.82656295
27MP0001835_abnormal_antigen_presentation1.78750451
28MP0005451_abnormal_body_composition1.75431243
29MP0005423_abnormal_somatic_nervous1.71899140
30MP0002098_abnormal_vibrissa_morphology1.68473312
31MP0005387_immune_system_phenotype1.63431788
32MP0001790_abnormal_immune_system1.63431788
33MP0009672_abnormal_birth_weight1.61305337
34MP0005409_darkened_coat_color1.61141892
35MP0002420_abnormal_adaptive_immunity1.60503535
36MP0000716_abnormal_immune_system1.59450603
37MP0002722_abnormal_immune_system1.59025896
38MP0003890_abnormal_embryonic-extraembry1.57964569
39MP0000689_abnormal_spleen_morphology1.56574548
40MP0001819_abnormal_immune_cell1.56446994
41MP0005075_abnormal_melanosome_morpholog1.56029438
42MP0002452_abnormal_antigen_presenting1.55249796
43MP0002080_prenatal_lethality1.50552111
44MP0002723_abnormal_immune_serum1.49282835
45MP0002086_abnormal_extraembryonic_tissu1.48516198
46MP0000465_gastrointestinal_hemorrhage1.46953592
47MP0004957_abnormal_blastocyst_morpholog1.46179725
48MP0003221_abnormal_cardiomyocyte_apopto1.44615472
49MP0009333_abnormal_splenocyte_physiolog1.43077664
50MP0003950_abnormal_plasma_membrane1.42861874
51MP0004381_abnormal_hair_follicle1.37643422
52MP0002095_abnormal_skin_pigmentation1.36124039
53MP0003567_abnormal_fetal_cardiomyocyte1.32582520
54MP0001986_abnormal_taste_sensitivity1.31995104
55MP0009278_abnormal_bone_marrow1.31666609
56MP0003121_genomic_imprinting1.30994418
57MP0002429_abnormal_blood_cell1.30974276
58MP0003300_gastrointestinal_ulcer1.30735180
59MP0000467_abnormal_esophagus_morphology1.30681830
60MP0001873_stomach_inflammation1.29484349
61MP0000685_abnormal_immune_system1.28678568
62MP0005000_abnormal_immune_tolerance1.25934588
63MP0009703_decreased_birth_body1.25869401
64MP0002210_abnormal_sex_determination1.25363928
65MP0001188_hyperpigmentation1.25282191
66MP0008995_early_reproductive_senescence1.24827339
67MP0002234_abnormal_pharynx_morphology1.24604706
68MP0000350_abnormal_cell_proliferation1.24206652
69MP0004185_abnormal_adipocyte_glucose1.23478054
70MP0001929_abnormal_gametogenesis1.22943547
71MP0002405_respiratory_system_inflammati1.22054306
72MP0002166_altered_tumor_susceptibility1.20907973
73MP0002796_impaired_skin_barrier1.19551765
74MP0003880_abnormal_central_pattern1.18789531
75MP0004197_abnormal_fetal_growth/weight/1.15415937
76MP0010352_gastrointestinal_tract_polyps1.13235776
77MP0000383_abnormal_hair_follicle1.12683539
78MP0003866_abnormal_defecation1.12161023
79MP0003786_premature_aging1.11339953
80MP0006035_abnormal_mitochondrial_morpho1.10937426
81MP0002089_abnormal_postnatal_growth/wei1.09959688
82MP0002102_abnormal_ear_morphology1.05825814
83MP0002092_abnormal_eye_morphology1.05177939
84MP0002928_abnormal_bile_duct1.03810839
85MP0000490_abnormal_crypts_of1.03165162
86MP0002132_abnormal_respiratory_system1.03136554
87MP0002006_tumorigenesis1.00900711
88MP0004233_abnormal_muscle_weight1.00135441
89MP0010155_abnormal_intestine_physiology0.98617475
90MP0002233_abnormal_nose_morphology0.98356266
91MP0003699_abnormal_female_reproductive0.98242502
92MP0001672_abnormal_embryogenesis/_devel0.96915367
93MP0005380_embryogenesis_phenotype0.96915367
94MP0003385_abnormal_body_wall0.96700813
95MP0002933_joint_inflammation0.95609880
96MP0000313_abnormal_cell_death0.95238956
97MP0001730_embryonic_growth_arrest0.93916524
98MP0002009_preneoplasia0.93773974
99MP0001145_abnormal_male_reproductive0.93664033
100MP0001849_ear_inflammation0.93153202
101MP0010630_abnormal_cardiac_muscle0.90747032
102MP0002019_abnormal_tumor_incidence0.90563384
103MP0002075_abnormal_coat/hair_pigmentati0.89811709
104MP0003943_abnormal_hepatobiliary_system0.89299876
105MP0008932_abnormal_embryonic_tissue0.89158637
106MP0002111_abnormal_tail_morphology0.89150212
107MP0005076_abnormal_cell_differentiation0.89089248
108MP0009053_abnormal_anal_canal0.88269927
109MP0006072_abnormal_retinal_apoptosis0.88172667
110MP0010678_abnormal_skin_adnexa0.87815795
111MP0000428_abnormal_craniofacial_morphol0.87293887
112MP0003315_abnormal_perineum_morphology0.86912452
113MP0000579_abnormal_nail_morphology0.86574611
114MP0003705_abnormal_hypodermis_morpholog0.86367933
115MP0005397_hematopoietic_system_phenotyp0.86208766
116MP0001545_abnormal_hematopoietic_system0.86208766
117MP0002085_abnormal_embryonic_tissue0.85732976
118MP0003718_maternal_effect0.85685703
119MP0000653_abnormal_sex_gland0.85322794
120MP0003984_embryonic_growth_retardation0.84452460
121MP0005501_abnormal_skin_physiology0.83586328
122MP0002088_abnormal_embryonic_growth/wei0.82889249
123MP0001919_abnormal_reproductive_system0.82695971
124MP0001293_anophthalmia0.81904635
125MP0003935_abnormal_craniofacial_develop0.81750467
126MP0002249_abnormal_larynx_morphology0.81700972
127MP0000733_abnormal_muscle_development0.81241178
128MP0004947_skin_inflammation0.81034848
129MP0008789_abnormal_olfactory_epithelium0.80565536
130MP0001186_pigmentation_phenotype0.80404243
131MP0002697_abnormal_eye_size0.80055601
132MP0004084_abnormal_cardiac_muscle0.79432648
133MP0003755_abnormal_palate_morphology0.78799269
134MP0001119_abnormal_female_reproductive0.78447013
135MP0002116_abnormal_craniofacial_bone0.77671768
136MP0000377_abnormal_hair_follicle0.77230627
137MP0002282_abnormal_trachea_morphology0.76766274
138MP0008961_abnormal_basal_metabolism0.76716975
139MP0010307_abnormal_tumor_latency0.76254012
140MP0001286_abnormal_eye_development0.75410747
141MP0005389_reproductive_system_phenotype0.75146832
142MP0003861_abnormal_nervous_system0.74929642
143MP0001340_abnormal_eyelid_morphology0.74179084
144MP0000566_synostosis0.73480526
145MP0002084_abnormal_developmental_patter0.73057832
146MP0000432_abnormal_head_morphology0.73045388
147MP0001697_abnormal_embryo_size0.72202351
148MP0003937_abnormal_limbs/digits/tail_de0.71711012
149MP0004510_myositis0.71305226
150MP0005025_abnormal_response_to0.70571419
151MP0003698_abnormal_male_reproductive0.70570899

Predicted human phenotypes

RankGene SetZ-score
1Flat acetabular roof (HP:0003180)5.60239455
2Carpal bone hypoplasia (HP:0001498)4.98413281
3Diaphragmatic weakness (HP:0009113)4.65787288
4Aplasia of the musculature (HP:0100854)4.54477406
5Abnormality of the distal phalanges of the toes (HP:0010182)4.47900920
6Obstructive sleep apnea (HP:0002870)4.44935921
7Chromosomal breakage induced by crosslinking agents (HP:0003221)4.40183931
8Hand muscle atrophy (HP:0009130)4.33378234
9Chromsome breakage (HP:0040012)4.30047898
10Abnormality of the fingertips (HP:0001211)4.21236179
11Spinal muscular atrophy (HP:0007269)4.09571951
12Panhypogammaglobulinemia (HP:0003139)4.05646628
13Stridor (HP:0010307)3.99688457
14Hip contracture (HP:0003273)3.96594151
15Hip dysplasia (HP:0001385)3.87753523
16Abnormal vertebral ossification (HP:0100569)3.86668049
17Abnormality of the phalanges of the hallux (HP:0010057)3.64706415
18Distal upper limb amyotrophy (HP:0007149)3.51273560
19Upper limb amyotrophy (HP:0009129)3.51273560
20Muscle fiber splitting (HP:0003555)3.50923279
21T lymphocytopenia (HP:0005403)3.49709250
22Aplasia/Hypoplasia involving the musculature (HP:0001460)3.46925263
23Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.45757485
24Volvulus (HP:0002580)3.41679646
25Spinal cord compression (HP:0002176)3.37922411
26Fetal akinesia sequence (HP:0001989)3.33012889
27Abnormality of the middle phalanges of the toes (HP:0010183)3.25583549
28High anterior hairline (HP:0009890)3.22360608
29Distal lower limb muscle weakness (HP:0009053)3.21319967
30Abnormality of T cell number (HP:0011839)3.15537750
31Recurrent viral infections (HP:0004429)2.93240587
32Thyroiditis (HP:0100646)2.92237191
33Down-sloping shoulders (HP:0200021)2.92213544
34Abnormality of carpal bone ossification (HP:0006257)2.89433907
35Birth length less than 3rd percentile (HP:0003561)2.89082591
36Severe combined immunodeficiency (HP:0004430)2.86803919
3711 pairs of ribs (HP:0000878)2.85391227
38B lymphocytopenia (HP:0010976)2.84849834
39Abnormality of B cell number (HP:0010975)2.84849834
40Duplicated collecting system (HP:0000081)2.84605211
41Abnormality of the preputium (HP:0100587)2.82448726
42Abnormal delayed hypersensitivity skin test (HP:0002963)2.80306141
43Agammaglobulinemia (HP:0004432)2.77833407
44Aplasia/Hypoplasia of the uvula (HP:0010293)2.76981560
45Rough bone trabeculation (HP:0100670)2.76757014
46Abnormality of chromosome stability (HP:0003220)2.76009600
47Abnormal lung lobation (HP:0002101)2.75557280
48Ectopic kidney (HP:0000086)2.74904252
49Limb-girdle muscle atrophy (HP:0003797)2.68257916
50Chronic otitis media (HP:0000389)2.67842171
51Midline defect of the nose (HP:0004122)2.66001557
52Abnormality of the renal collecting system (HP:0004742)2.58987040
53Abnormality of the vocal cords (HP:0008777)2.55453507
54Difficulty running (HP:0009046)2.51935158
55Meckel diverticulum (HP:0002245)2.51484558
56Clubbing of toes (HP:0100760)2.50910663
57IgM deficiency (HP:0002850)2.49777536
58Abnormality of DNA repair (HP:0003254)2.46671077
59Combined immunodeficiency (HP:0005387)2.46052351
60Epiphyseal dysplasia (HP:0002656)2.45866768
61Short middle phalanx of finger (HP:0005819)2.45578919
62Abnormality of the ileum (HP:0001549)2.44075591
63Recurrent fungal infections (HP:0002841)2.41833405
64Abnormality of the carotid arteries (HP:0005344)2.40506729
65Myelodysplasia (HP:0002863)2.39449395
66Acute lymphatic leukemia (HP:0006721)2.39426445
67Limited hip movement (HP:0008800)2.38478893
68Lower limb asymmetry (HP:0100559)2.38189501
69Long eyelashes (HP:0000527)2.37015493
70Broad face (HP:0000283)2.33663864
71Abnormal ossification of hand bones (HP:0005921)2.32775945
72Supernumerary spleens (HP:0009799)2.32585319
73Barrel-shaped chest (HP:0001552)2.30613601
74Eosinophilia (HP:0001880)2.30607057
75Granulocytopenia (HP:0001913)2.28350468
76Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.28160242
77IgG deficiency (HP:0004315)2.26048312
78Abnormal trabecular bone morphology (HP:0100671)2.25483999
79Chronic mucocutaneous candidiasis (HP:0002728)2.25017805
80Recurrent cutaneous fungal infections (HP:0011370)2.25017805
81Scapular winging (HP:0003691)2.24713669
82Abnormality of T cells (HP:0002843)2.23957154
83Progressive muscle weakness (HP:0003323)2.23770215
84Achilles tendon contracture (HP:0001771)2.22658829
85Abnormality of eosinophils (HP:0001879)2.21309434
86Hypoplasia of the odontoid process (HP:0003311)2.18510321
87Knee flexion contracture (HP:0006380)2.16999510
88Abnormal hand bone ossification (HP:0010660)2.13126169
89Anal stenosis (HP:0002025)2.11628954
90Multiple enchondromatosis (HP:0005701)2.10972212
91Abnormality of the intervertebral disk (HP:0005108)2.10439248
92Flared metaphyses (HP:0003015)2.10012733
93Recurrent bronchitis (HP:0002837)2.09594998
94Patellar aplasia (HP:0006443)2.08185537
95Abnormality of the musculature of the hand (HP:0001421)2.06411457
96Hypoplasia of the thymus (HP:0000778)2.06228244
97Metaphyseal cupping (HP:0003021)2.04856779
98Abnormal hair whorl (HP:0010721)2.01581734
99Duodenal stenosis (HP:0100867)1.98036198
100Small intestinal stenosis (HP:0012848)1.98036198
101Aplasia/Hypoplasia of the earlobes (HP:0009906)1.96760765
102Prominent nose (HP:0000448)1.96546338
103Skull defect (HP:0001362)1.96538427
104Bone marrow hypocellularity (HP:0005528)1.95947952
105Lip pit (HP:0100267)1.94192305
106Deep philtrum (HP:0002002)1.92811386
107Lymphoma (HP:0002665)1.92578753
108Lymphopenia (HP:0001888)1.92552834
109Abnormality of the Achilles tendon (HP:0005109)1.91054801
110Aplasia/Hypoplasia of the patella (HP:0006498)1.88394874
111Medulloblastoma (HP:0002885)1.88242364
112Facial hemangioma (HP:0000329)1.86380294
113Recurrent sinusitis (HP:0011108)1.85572811
114Abnormality of cells of the lymphoid lineage (HP:0012140)1.84205897
115Meningitis (HP:0001287)1.83348114
116Premature ovarian failure (HP:0008209)1.83186548
117Neoplasm of the oral cavity (HP:0100649)1.83178601
118Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.82665845
119Short 4th metacarpal (HP:0010044)1.82665845
120Reticulocytopenia (HP:0001896)1.82592758
121Septate vagina (HP:0001153)1.82178390
122Supernumerary ribs (HP:0005815)1.82162769
123Disproportionate tall stature (HP:0001519)1.82029458
124Asymmetric growth (HP:0100555)1.81669305
125Small epiphyses (HP:0010585)1.81510353
126Metaphyseal irregularity (HP:0003025)1.80933904
127Abnormal foot bone ossification (HP:0010675)1.80383126
128Overlapping toe (HP:0001845)1.80332273
129Impulsivity (HP:0100710)1.79570137
130Acute myeloid leukemia (HP:0004808)1.79459272
131Supernumerary bones of the axial skeleton (HP:0009144)1.78508263
132Sleep apnea (HP:0010535)1.78065499
133Ependymoma (HP:0002888)1.77797193
134Metatarsus adductus (HP:0001840)1.77122468
135Broad palm (HP:0001169)1.77032463
136Disproportionate short-trunk short stature (HP:0003521)1.75187548
137Abnormality of the aortic arch (HP:0012303)1.74843532
138Abnormality of chromosome segregation (HP:0002916)1.74169597
139Heterotopia (HP:0002282)1.74107999
140Small hand (HP:0200055)1.73899339
141Broad distal phalanx of finger (HP:0009836)1.73442656
142Leukopenia (HP:0001882)1.73378373
143Increased nuchal translucency (HP:0010880)1.73370437
144Tracheal stenosis (HP:0002777)1.72615589
145Sloping forehead (HP:0000340)1.71855189
146Abnormality of oral frenula (HP:0000190)1.71838374
147Short tibia (HP:0005736)1.70608138
148Microvesicular hepatic steatosis (HP:0001414)1.69840466
149Capillary hemangiomas (HP:0005306)1.69234961
150Recurrent otitis media (HP:0000403)1.69173681
151Basal cell carcinoma (HP:0002671)1.68958368
152Trigonocephaly (HP:0000243)1.68068662
153Abnormality of the odontoid process (HP:0003310)1.66786479
154Optic nerve coloboma (HP:0000588)1.65747186
155Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.65634539
156Abnormality of the columella (HP:0009929)1.65482733
157Deviation of the thumb (HP:0009603)1.65417383
158Proximal placement of thumb (HP:0009623)1.64609496
159IgA deficiency (HP:0002720)1.63975360
160Leukocytosis (HP:0001974)1.63846884
161Abnormality of the labia minora (HP:0012880)1.63655593
162Microtia (HP:0008551)1.62439000
163Colon cancer (HP:0003003)1.59950660
164Long clavicles (HP:0000890)1.59428835
165Abnormal gallbladder physiology (HP:0012438)1.59343577
166Cholecystitis (HP:0001082)1.59343577
167Abnormality of the duodenum (HP:0002246)1.58200918
168Short thumb (HP:0009778)1.57633994
169Bowel incontinence (HP:0002607)1.57424225
170Chronic sinusitis (HP:0011109)1.56826715
171Cellular immunodeficiency (HP:0005374)1.56555507
172Urethral obstruction (HP:0000796)1.56409817
173Sparse lateral eyebrow (HP:0005338)1.55864471
174Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.54877457
175Limited elbow extension (HP:0001377)1.54874700
176Obsessive-compulsive behavior (HP:0000722)1.54577852
177Missing ribs (HP:0000921)1.54489276
178Abnormality of the right ventricle (HP:0001707)1.53495998
179Oligodactyly (hands) (HP:0001180)1.53226087
180Abnormality of the incisor (HP:0000676)1.52949997
181Bronchiectasis (HP:0002110)1.52276675
182Tented upper lip vermilion (HP:0010804)1.50733896
183Absent thumb (HP:0009777)1.49582739
184Cafe-au-lait spot (HP:0000957)1.48516393

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K13.61511036
2SMG13.45411347
3CDK123.32747032
4TXK3.17263369
5BRD42.89091870
6IRAK32.60351676
7SIK22.06229610
8TRIB32.03063079
9CDC71.99059544
10SRPK11.97394159
11EEF2K1.92171808
12STK161.90933145
13VRK21.84957944
14FGFR41.75788160
15BUB11.75607096
16ZAK1.75471504
17ITK1.74966326
18PLK41.73219697
19NEK21.71820801
20IRAK41.63347282
21STK101.61586154
22MAP3K101.61179476
23JAK31.58511771
24ICK1.54242702
25ATR1.52239487
26LATS11.49366449
27NLK1.46135630
28TRIM281.45470743
29EPHA21.44673157
30BTK1.41640080
31MKNK21.40338447
32PBK1.36005217
33BRSK21.32357364
34MAPK71.30718967
35YES11.29542460
36MAP3K141.27595759
37FER1.24999731
38PRPF4B1.23190335
39EPHB11.22359801
40ACVR1B1.20061442
41TTK1.18664426
42TEC1.17959247
43MARK21.17650845
44EIF2AK11.15264931
45CLK11.14861996
46CHEK11.14825947
47CHEK21.13230098
48PKN21.11653648
49PNCK1.11650379
50BRSK11.09508318
51SYK1.09205879
52ZAP701.06673390
53SIK11.05745037
54CAMK1G1.04656202
55CDC42BPA1.04319045
56LCK1.03828734
57MELK1.03182702
58CDK71.02629271
59ATM1.01167701
60FGFR31.01097431
61CHUK0.99909104
62FGFR20.98830494
63CDK80.98331202
64KSR20.98245138
65CDK90.97310227
66VRK10.97237638
67TLK10.97191152
68MARK10.95984030
69HCK0.95662186
70* MTOR0.95423178
71NME10.94393880
72STK40.93489053
73PTK60.92963631
74PASK0.91381932
75TAOK30.90893276
76LMTK20.89618123
77TSSK60.89587559
78CDK40.88616473
79IKBKE0.88512746
80RPS6KA40.87269046
81STK380.86789082
82PRKD20.86675822
83TYK20.85406435
84TAF10.84539475
85NUAK10.84056016
86PLK10.83337891
87CAMK1D0.83254860
88MKNK10.83107572
89IKBKB0.83027188
90MAP3K70.82396982
91PIM10.81688001
92PRKD30.80491672
93SGK20.79156233
94SGK30.78532242
95PLK30.78198302
96CDK20.77210775
97GRK60.76810242
98AURKB0.74626372
99LYN0.72060624
100CDK60.71978336
101JAK10.71237837
102NEK60.71095679
103* CDK10.68836927
104NTRK20.68520825
105FGFR10.67179773
106RPS6KB20.66685755
107HIPK20.66611222
108SIK30.64992528
109PRKAA20.64620914
110TGFBR10.63687553
111CSF1R0.63183408
112MARK30.62546415
113PRKCQ0.61827604
114TNK20.60776254
115STK30.60344247
116MAP3K130.59746756
117MET0.59058343
118KSR10.58731705
119FES0.58470712
120BLK0.58050986
121RPS6KA50.57682766
122MST1R0.57670191
123CSK0.56381770
124STK240.55439669
125PRKAA10.54549696
126EIF2AK30.53826386
127MAPK130.53274582
128* MAPK140.52713951
129PRKDC0.52041148
130EIF2AK20.51520136
131MAP3K80.51242063
132RAF10.51171682
133WEE10.50580991
134MAPK110.50487563
135IRAK10.50268997
136PRKCH0.49682738
137TYRO30.49596135
138KIT0.49279056
139IRAK20.48480921
140CDK30.46656552
141STK390.46076655
142PAK40.45746797
143CSNK1E0.40371219
144* GSK3B0.40291169
145WNK40.38694375
146CSNK2A20.37681161

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053403.34373587
2Fanconi anemia pathway_Homo sapiens_hsa034602.68292275
3Non-homologous end-joining_Homo sapiens_hsa034502.31101052
4Mismatch repair_Homo sapiens_hsa034302.14252267
5Spliceosome_Homo sapiens_hsa030402.07737133
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.06263970
7Base excision repair_Homo sapiens_hsa034102.03469447
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.00939984
9DNA replication_Homo sapiens_hsa030301.98522497
10mRNA surveillance pathway_Homo sapiens_hsa030151.88797489
11T cell receptor signaling pathway_Homo sapiens_hsa046601.88049556
12Homologous recombination_Homo sapiens_hsa034401.83201279
13RNA polymerase_Homo sapiens_hsa030201.82441143
14Cell cycle_Homo sapiens_hsa041101.80424590
15RNA transport_Homo sapiens_hsa030131.65740227
16RNA degradation_Homo sapiens_hsa030181.58717259
17Basal transcription factors_Homo sapiens_hsa030221.55060083
18Thyroid cancer_Homo sapiens_hsa052161.51889355
19B cell receptor signaling pathway_Homo sapiens_hsa046621.51782332
20Measles_Homo sapiens_hsa051621.44905077
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.41995985
22Nucleotide excision repair_Homo sapiens_hsa034201.34146960
23Transcriptional misregulation in cancer_Homo sapiens_hsa052021.31071628
24Herpes simplex infection_Homo sapiens_hsa051681.28105034
25Epstein-Barr virus infection_Homo sapiens_hsa051691.25554797
26Dorso-ventral axis formation_Homo sapiens_hsa043201.21872497
27Hematopoietic cell lineage_Homo sapiens_hsa046401.19117029
28p53 signaling pathway_Homo sapiens_hsa041151.16748696
29HTLV-I infection_Homo sapiens_hsa051661.16619868
30Biosynthesis of amino acids_Homo sapiens_hsa012301.16579712
31Central carbon metabolism in cancer_Homo sapiens_hsa052301.13292987
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.12307151
33Lysine degradation_Homo sapiens_hsa003101.10721491
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.10113661
35Notch signaling pathway_Homo sapiens_hsa043301.09642555
36Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.07468509
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.07190810
38Cyanoamino acid metabolism_Homo sapiens_hsa004601.07050657
39Antigen processing and presentation_Homo sapiens_hsa046121.06938473
40mTOR signaling pathway_Homo sapiens_hsa041501.05278310
41NOD-like receptor signaling pathway_Homo sapiens_hsa046211.03934894
42Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03053222
43Phototransduction_Homo sapiens_hsa047441.01732001
44Pentose phosphate pathway_Homo sapiens_hsa000301.01399893
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01101218
46Osteoclast differentiation_Homo sapiens_hsa043801.00822090
47MicroRNAs in cancer_Homo sapiens_hsa052060.99786899
48Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.98351256
49Viral carcinogenesis_Homo sapiens_hsa052030.98229373
50N-Glycan biosynthesis_Homo sapiens_hsa005100.94239437
51Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.94064914
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.90556307
53Pyrimidine metabolism_Homo sapiens_hsa002400.88739196
54Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.88591390
55Jak-STAT signaling pathway_Homo sapiens_hsa046300.88268151
56Colorectal cancer_Homo sapiens_hsa052100.88222744
57Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87583484
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.87378622
59Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.87087577
60Longevity regulating pathway - mammal_Homo sapiens_hsa042110.86307490
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85682204
62Steroid biosynthesis_Homo sapiens_hsa001000.85484788
63Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84996953
64Hepatitis B_Homo sapiens_hsa051610.84961305
65Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.84480172
66Carbon metabolism_Homo sapiens_hsa012000.84020679
67Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.83987932
68Chronic myeloid leukemia_Homo sapiens_hsa052200.83651520
69One carbon pool by folate_Homo sapiens_hsa006700.82001369
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.79272911
71Pancreatic cancer_Homo sapiens_hsa052120.78648883
72TGF-beta signaling pathway_Homo sapiens_hsa043500.77808610
73Insulin signaling pathway_Homo sapiens_hsa049100.76175183
74Chemokine signaling pathway_Homo sapiens_hsa040620.75946727
75Fructose and mannose metabolism_Homo sapiens_hsa000510.75628434
76FoxO signaling pathway_Homo sapiens_hsa040680.74735171
77Acute myeloid leukemia_Homo sapiens_hsa052210.73771561
78Small cell lung cancer_Homo sapiens_hsa052220.73127188
79Renal cell carcinoma_Homo sapiens_hsa052110.72910550
80Influenza A_Homo sapiens_hsa051640.71658120
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.71004401
82Ribosome_Homo sapiens_hsa030100.70460488
83Purine metabolism_Homo sapiens_hsa002300.70155384
84Leishmaniasis_Homo sapiens_hsa051400.69708766
85Autoimmune thyroid disease_Homo sapiens_hsa053200.68111591
86Prostate cancer_Homo sapiens_hsa052150.67801239
87Systemic lupus erythematosus_Homo sapiens_hsa053220.67534948
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67342342
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64949670
90Viral myocarditis_Homo sapiens_hsa054160.64608956
91Leukocyte transendothelial migration_Homo sapiens_hsa046700.64193613
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63077544
93Oocyte meiosis_Homo sapiens_hsa041140.62427779
94Toxoplasmosis_Homo sapiens_hsa051450.61651391
95Platelet activation_Homo sapiens_hsa046110.61522662
96MAPK signaling pathway_Homo sapiens_hsa040100.60493839
97Hedgehog signaling pathway_Homo sapiens_hsa043400.60112914
98Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59851482
99Basal cell carcinoma_Homo sapiens_hsa052170.59494057
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59301162
101Apoptosis_Homo sapiens_hsa042100.59048472
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57784217
103HIF-1 signaling pathway_Homo sapiens_hsa040660.57729200
104Pathways in cancer_Homo sapiens_hsa052000.57724673
105Shigellosis_Homo sapiens_hsa051310.56714336
106Circadian rhythm_Homo sapiens_hsa047100.56170755
107Wnt signaling pathway_Homo sapiens_hsa043100.55703341
108Allograft rejection_Homo sapiens_hsa053300.55484174
109Proteasome_Homo sapiens_hsa030500.55040124
110Prolactin signaling pathway_Homo sapiens_hsa049170.54583940
111Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54140339
112TNF signaling pathway_Homo sapiens_hsa046680.53449796
113Inositol phosphate metabolism_Homo sapiens_hsa005620.52896099
114Other glycan degradation_Homo sapiens_hsa005110.49440993
115Non-small cell lung cancer_Homo sapiens_hsa052230.49412923
116Vitamin digestion and absorption_Homo sapiens_hsa049770.49368474
117Insulin resistance_Homo sapiens_hsa049310.49150664
118Toll-like receptor signaling pathway_Homo sapiens_hsa046200.48080477
119Selenocompound metabolism_Homo sapiens_hsa004500.47387161
120Adherens junction_Homo sapiens_hsa045200.45681378
121Hippo signaling pathway_Homo sapiens_hsa043900.45659152
122Choline metabolism in cancer_Homo sapiens_hsa052310.45582172
123ABC transporters_Homo sapiens_hsa020100.44579038
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.42687426
125Sphingolipid signaling pathway_Homo sapiens_hsa040710.41786384
126Graft-versus-host disease_Homo sapiens_hsa053320.41044949
127Proteoglycans in cancer_Homo sapiens_hsa052050.40554967
128Regulation of autophagy_Homo sapiens_hsa041400.40125607
129Bladder cancer_Homo sapiens_hsa052190.39456561
130Hepatitis C_Homo sapiens_hsa051600.39044352
131Phospholipase D signaling pathway_Homo sapiens_hsa040720.38995220
132Alcoholism_Homo sapiens_hsa050340.38811214
133AMPK signaling pathway_Homo sapiens_hsa041520.38568947
134Drug metabolism - other enzymes_Homo sapiens_hsa009830.38538755
135Endometrial cancer_Homo sapiens_hsa052130.37420610
136Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37192031
137ErbB signaling pathway_Homo sapiens_hsa040120.35811007
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35790687
139Pyruvate metabolism_Homo sapiens_hsa006200.35639814
140Glucagon signaling pathway_Homo sapiens_hsa049220.31520627

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