NFU1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that is localized to mitochondria and plays a critical role in iron-sulfur cluster biogenesis. The encoded protein assembles and transfers 4Fe-4S clusters to target apoproteins including succinate dehydrogenase and lipoic acid synthase. Mutations in this gene are a cause of multiple mitochondrial dysfunctions syndrome-1, and pseudogenes of this gene are located on the short arms of chromosomes 1 and 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.89543903
2ATP synthesis coupled proton transport (GO:0015986)5.54214474
3energy coupled proton transport, down electrochemical gradient (GO:0015985)5.54214474
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.94732079
5proteasome assembly (GO:0043248)4.89526659
6mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.87843200
7mitochondrial respiratory chain complex I assembly (GO:0032981)4.87843200
8NADH dehydrogenase complex assembly (GO:0010257)4.87843200
9protein complex biogenesis (GO:0070271)4.84870640
10mitochondrial respiratory chain complex assembly (GO:0033108)4.58928112
11respiratory electron transport chain (GO:0022904)4.55928784
12oxidative phosphorylation (GO:0006119)4.47034923
13electron transport chain (GO:0022900)4.45589036
14regulation of mitochondrial translation (GO:0070129)4.39590520
15cullin deneddylation (GO:0010388)4.21093863
16ribosomal small subunit assembly (GO:0000028)4.20357419
17chaperone-mediated protein transport (GO:0072321)4.15361479
18protein deneddylation (GO:0000338)4.14750738
19transcription elongation from RNA polymerase III promoter (GO:0006385)4.12929833
20termination of RNA polymerase III transcription (GO:0006386)4.12929833
21negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.08717422
22DNA deamination (GO:0045006)4.08708184
23protein neddylation (GO:0045116)4.03966197
24L-methionine biosynthetic process from methylthioadenosine (GO:0019509)4.01527246
257-methylguanosine mRNA capping (GO:0006370)4.00763076
267-methylguanosine RNA capping (GO:0009452)3.92872848
27RNA capping (GO:0036260)3.92872848
28positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.83470960
29rRNA modification (GO:0000154)3.79776988
30regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.78557639
31DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.78236342
32respiratory chain complex IV assembly (GO:0008535)3.77370397
33regulation of cellular amino acid metabolic process (GO:0006521)3.75840230
34establishment of protein localization to mitochondrial membrane (GO:0090151)3.74807511
35negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.72254057
36negative regulation of ligase activity (GO:0051352)3.72254057
37intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.71310618
38signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.71310618
39anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.70335533
40signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.70208945
41signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.70208945
42signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.70208945
43water-soluble vitamin biosynthetic process (GO:0042364)3.69342076
44maturation of SSU-rRNA (GO:0030490)3.62334409
45telomere maintenance via semi-conservative replication (GO:0032201)3.59761234
46signal transduction involved in DNA integrity checkpoint (GO:0072401)3.59320420
47signal transduction involved in DNA damage checkpoint (GO:0072422)3.59320420
48cytochrome complex assembly (GO:0017004)3.56261708
49signal transduction involved in cell cycle checkpoint (GO:0072395)3.54359987
50aerobic respiration (GO:0009060)3.54193023
51antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.51629754
52branched-chain amino acid catabolic process (GO:0009083)3.51627035
53ribosomal small subunit biogenesis (GO:0042274)3.47910864
54protein targeting to mitochondrion (GO:0006626)3.45854293
55tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.45192065
56RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.45192065
57transcription-coupled nucleotide-excision repair (GO:0006283)3.42528573
58establishment of integrated proviral latency (GO:0075713)3.41104469
59establishment of protein localization to mitochondrion (GO:0072655)3.40788624
60cellular component biogenesis (GO:0044085)3.40590695
61pseudouridine synthesis (GO:0001522)3.39925947
62deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.37704867
63formation of translation preinitiation complex (GO:0001731)3.34603074
64positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.32645488
65exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.30418984
66nucleobase biosynthetic process (GO:0046112)3.30269459
67purine nucleobase biosynthetic process (GO:0009113)3.29174692
68amino acid salvage (GO:0043102)3.28611306
69L-methionine salvage (GO:0071267)3.28611306
70L-methionine biosynthetic process (GO:0071265)3.28611306
71termination of RNA polymerase I transcription (GO:0006363)3.28184073
72antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.27605686
73DNA strand elongation involved in DNA replication (GO:0006271)3.26432803
74rRNA methylation (GO:0031167)3.26429848
75telomere maintenance via recombination (GO:0000722)3.25791692
76positive regulation of ligase activity (GO:0051351)3.23146395
77ribosomal large subunit biogenesis (GO:0042273)3.22033253
78transcription elongation from RNA polymerase I promoter (GO:0006362)3.21282839
79translation (GO:0006412)3.20578339
80transcription from RNA polymerase I promoter (GO:0006360)3.19693069
81GTP biosynthetic process (GO:0006183)3.18644363
82ribonucleoprotein complex biogenesis (GO:0022613)3.17517166
83protein localization to mitochondrion (GO:0070585)3.15303983
84DNA strand elongation (GO:0022616)3.11952664
85viral transcription (GO:0019083)3.09974372
86ribosome biogenesis (GO:0042254)3.08654256
87ATP biosynthetic process (GO:0006754)3.08364810
88peptidyl-histidine modification (GO:0018202)3.07983857
89translational termination (GO:0006415)3.07830276
90intracellular protein transmembrane import (GO:0044743)3.07058715
91guanosine-containing compound biosynthetic process (GO:1901070)3.05984322
92platelet dense granule organization (GO:0060155)3.05510701
93DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.04698914
94CENP-A containing nucleosome assembly (GO:0034080)3.01161796
95DNA replication checkpoint (GO:0000076)3.00782459
96hydrogen ion transmembrane transport (GO:1902600)3.00356710
97rRNA processing (GO:0006364)3.00121028
98DNA replication initiation (GO:0006270)2.98194888
99ubiquinone metabolic process (GO:0006743)2.96548456
100protein-cofactor linkage (GO:0018065)2.96369669
101regulation of ubiquitin-protein transferase activity (GO:0051438)2.94205608
102nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.94020526
103purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.93900498
104cotranslational protein targeting to membrane (GO:0006613)2.93608252
105maturation of 5.8S rRNA (GO:0000460)2.93048752
106SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.92911831
107DNA damage response, detection of DNA damage (GO:0042769)2.91762264
108purine nucleoside triphosphate biosynthetic process (GO:0009145)2.91623484
109spliceosomal snRNP assembly (GO:0000387)2.90803345
110positive regulation of cell cycle arrest (GO:0071158)2.90474355
111mitochondrial transport (GO:0006839)2.90185956
112viral mRNA export from host cell nucleus (GO:0046784)2.89380588
113translational elongation (GO:0006414)2.88906818
114chromatin remodeling at centromere (GO:0031055)2.86674176
115inositol phosphate catabolic process (GO:0071545)2.86264607
116proton transport (GO:0015992)2.81616262
117anterograde synaptic vesicle transport (GO:0048490)2.81278641
118mannosylation (GO:0097502)2.79844933
119DNA double-strand break processing (GO:0000729)2.78258304
120hydrogen transport (GO:0006818)2.75983695
121lactate metabolic process (GO:0006089)2.72493280
122regulation of hexokinase activity (GO:1903299)2.67056941
123regulation of glucokinase activity (GO:0033131)2.67056941
124regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.65405029
125inner mitochondrial membrane organization (GO:0007007)2.65382126
126phosphorylated carbohydrate dephosphorylation (GO:0046838)2.64947249
127inositol phosphate dephosphorylation (GO:0046855)2.64947249
128pteridine-containing compound biosynthetic process (GO:0042559)2.64535045
129branched-chain amino acid metabolic process (GO:0009081)2.63293787
130protein K11-linked ubiquitination (GO:0070979)2.62193136
131negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.60448257
132ubiquinone biosynthetic process (GO:0006744)2.58515944
133synapsis (GO:0007129)2.58134433
134intraciliary transport (GO:0042073)2.56273064
135histone exchange (GO:0043486)2.53503691
136histone H2A acetylation (GO:0043968)2.52271727
137ribonucleoside triphosphate biosynthetic process (GO:0009201)2.51477041
138piRNA metabolic process (GO:0034587)2.47326771
139regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.47010850
140regulation of mitotic spindle checkpoint (GO:1903504)2.47010850
141nucleoside triphosphate biosynthetic process (GO:0009142)2.42666946
142purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.41700190
143purine nucleoside monophosphate biosynthetic process (GO:0009127)2.41700190

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.98416370
2E2F7_22180533_ChIP-Seq_HELA_Human4.44372532
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.11925245
4JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.08422823
5EST1_17652178_ChIP-ChIP_JURKAT_Human4.04862041
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.97773306
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.92646040
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.76655369
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.47973123
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.26787254
11HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.25880956
12* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.17589553
13* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.12222867
14CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.10620802
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.97061407
16SRF_21415370_ChIP-Seq_HL-1_Mouse2.78185913
17CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.74413105
18ELF1_17652178_ChIP-ChIP_JURKAT_Human2.74318632
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68055735
20VDR_23849224_ChIP-Seq_CD4+_Human2.61027414
21ZNF274_21170338_ChIP-Seq_K562_Hela2.50671176
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.50029274
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.41842249
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.38995094
25* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.37205050
26YY1_21170310_ChIP-Seq_MESCs_Mouse2.34617674
27DCP1A_22483619_ChIP-Seq_HELA_Human2.30791524
28VDR_22108803_ChIP-Seq_LS180_Human2.25474176
29E2F4_17652178_ChIP-ChIP_JURKAT_Human2.25353405
30FOXP3_21729870_ChIP-Seq_TREG_Human2.25017332
31FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.21633179
32PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.21049715
33MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.15711790
34NELFA_20434984_ChIP-Seq_ESCs_Mouse2.09341090
35POU3F2_20337985_ChIP-ChIP_501MEL_Human2.06442774
36* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.04458034
37XRN2_22483619_ChIP-Seq_HELA_Human2.02430927
38ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.99549212
39EWS_26573619_Chip-Seq_HEK293_Human1.98285765
40IGF1R_20145208_ChIP-Seq_DFB_Human1.98266859
41ELK1_19687146_ChIP-ChIP_HELA_Human1.95600250
42GABP_19822575_ChIP-Seq_HepG2_Human1.94149113
43FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.92312051
44HOXB4_20404135_ChIP-ChIP_EML_Mouse1.86894294
45TTF2_22483619_ChIP-Seq_HELA_Human1.85611813
46PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82427249
47* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.80831636
48ZFP57_27257070_Chip-Seq_ESCs_Mouse1.79159746
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76208806
50POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.75983399
51FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.74402317
52NANOG_18555785_ChIP-Seq_MESCs_Mouse1.66591716
53MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.63767247
54HTT_18923047_ChIP-ChIP_STHdh_Human1.52769254
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.50937308
56P300_19829295_ChIP-Seq_ESCs_Human1.50055269
57GBX2_23144817_ChIP-Seq_PC3_Human1.46967613
58TP53_22573176_ChIP-Seq_HFKS_Human1.46095684
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.45406776
60TAF15_26573619_Chip-Seq_HEK293_Human1.42588750
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.41932098
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39469947
63* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.37172462
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35639897
65* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34351248
66* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.32207122
67RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.31249550
68CTBP2_25329375_ChIP-Seq_LNCAP_Human1.30455744
69CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29834652
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.26152037
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.24505105
72IRF1_19129219_ChIP-ChIP_H3396_Human1.21624100
73MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21436007
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.20694984
75ELK1_22589737_ChIP-Seq_MCF10A_Human1.20119978
76MYC_18940864_ChIP-ChIP_HL60_Human1.19925822
77SALL1_21062744_ChIP-ChIP_HESCs_Human1.19904129
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19227513
79SOX2_19829295_ChIP-Seq_ESCs_Human1.19152085
80NANOG_19829295_ChIP-Seq_ESCs_Human1.19152085
81RBPJ_22232070_ChIP-Seq_NCS_Mouse1.17628224
82SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16102031
83NOTCH1_21737748_ChIP-Seq_TLL_Human1.15342251
84* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.15255370
85SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14635112
86POU5F1_16153702_ChIP-ChIP_HESCs_Human1.13532810
87* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.11076848
88SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.10636275
89ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10350667
90CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.09804845
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.09445675
92FOXA1_25329375_ChIP-Seq_VCAP_Human1.09041017
93FOXA1_27270436_Chip-Seq_PROSTATE_Human1.09041017
94HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08261368
95ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06333110
96CIITA_25753668_ChIP-Seq_RAJI_Human1.04516958
97TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02920408
98ER_23166858_ChIP-Seq_MCF-7_Human1.01979255
99CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.01841984
100FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01803753
101NANOG_16153702_ChIP-ChIP_HESCs_Human1.01501834
102CBP_20019798_ChIP-Seq_JUKART_Human1.01096800
103IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01096800
104CRX_20693478_ChIP-Seq_RETINA_Mouse1.01086605
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.00524568
106* KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99113181
107E2F1_21310950_ChIP-Seq_MCF-7_Human0.98673084
108BCAT_22108803_ChIP-Seq_LS180_Human0.97662449
109BMI1_23680149_ChIP-Seq_NPCS_Mouse0.97631602
110IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.97568339
111CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97335961
112PCGF2_27294783_Chip-Seq_NPCs_Mouse0.97056440
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.96967851
114POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.96451463
115NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.95766067
116* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.94892295
117KDM5A_27292631_Chip-Seq_BREAST_Human0.94723855
118GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.94269634
119AR_20517297_ChIP-Seq_VCAP_Human0.94005348
120* STAT3_1855785_ChIP-Seq_MESCs_Mouse0.93997335
121SOX2_16153702_ChIP-ChIP_HESCs_Human0.92806745
122SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90502851
123CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90272824
124AR_25329375_ChIP-Seq_VCAP_Human0.89635663
125TOP2B_26459242_ChIP-Seq_MCF-7_Human0.89314109
126RNF2_27304074_Chip-Seq_NSC_Mouse0.87492821
127TCF4_22108803_ChIP-Seq_LS180_Human0.87315105
128PHF8_20622853_ChIP-Seq_HELA_Human0.87156677
129MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.87052561
130BP1_19119308_ChIP-ChIP_Hs578T_Human0.87050928
131SPI1_23547873_ChIP-Seq_NB4_Human0.84805604
132FLI1_27457419_Chip-Seq_LIVER_Mouse0.83051041
133KAP1_22055183_ChIP-Seq_ESCs_Mouse0.79593004
134GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.78798125
135NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.78143299
136PCGF2_27294783_Chip-Seq_ESCs_Mouse0.77057962
137CTCF_18555785_ChIP-Seq_MESCs_Mouse0.75302671
138FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73279727
139E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.71860491
140AR_21909140_ChIP-Seq_LNCAP_Human0.71765609
141SOX17_20123909_ChIP-Seq_XEN_Mouse0.70984425
142KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.70680438
143IRF8_21731497_ChIP-ChIP_J774_Mouse0.70185149
144HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.70026506
145HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.69433690
146SOX2_18692474_ChIP-Seq_MEFs_Mouse0.69282183
147FOXM1_23109430_ChIP-Seq_U2OS_Human0.68535135
148DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.68243742
149TFEB_21752829_ChIP-Seq_HELA_Human0.68069758
150FUS_26573619_Chip-Seq_HEK293_Human0.68066397

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.09744878
2MP0001529_abnormal_vocalization3.31174259
3MP0003806_abnormal_nucleotide_metabolis3.24319004
4MP0010094_abnormal_chromosome_stability3.15094303
5MP0004957_abnormal_blastocyst_morpholog3.00525415
6MP0008058_abnormal_DNA_repair3.00400173
7MP0001986_abnormal_taste_sensitivity2.99020682
8MP0006036_abnormal_mitochondrial_physio2.97664849
9MP0003646_muscle_fatigue2.97042881
10MP0008057_abnormal_DNA_replication2.80393320
11MP0006072_abnormal_retinal_apoptosis2.56004210
12MP0003077_abnormal_cell_cycle2.39390194
13MP0003111_abnormal_nucleus_morphology2.37235223
14MP0003718_maternal_effect2.34029237
15MP0006035_abnormal_mitochondrial_morpho2.26829233
16MP0003195_calcinosis2.22209195
17MP0003186_abnormal_redox_activity2.14522844
18MP0009697_abnormal_copulation2.13339756
19MP0008877_abnormal_DNA_methylation2.10347161
20MP0002837_dystrophic_cardiac_calcinosis2.09416890
21MP0001905_abnormal_dopamine_level2.01901754
22MP0004145_abnormal_muscle_electrophysio1.97382696
23MP0008932_abnormal_embryonic_tissue1.96436253
24MP0003786_premature_aging1.95505723
25MP0002163_abnormal_gland_morphology1.89334993
26MP0005075_abnormal_melanosome_morpholog1.74517471
27MP0005253_abnormal_eye_physiology1.74465977
28MP0006292_abnormal_olfactory_placode1.73377550
29MP0002132_abnormal_respiratory_system1.73372854
30MP0008260_abnormal_autophagy1.71019354
31MP0001188_hyperpigmentation1.70369190
32MP0001764_abnormal_homeostasis1.69076402
33MP0009379_abnormal_foot_pigmentation1.68365435
34MP0001984_abnormal_olfaction1.60881450
35MP0008789_abnormal_olfactory_epithelium1.58299993
36MP0006276_abnormal_autonomic_nervous1.56781546
37MP0000372_irregular_coat_pigmentation1.56180241
38MP0008007_abnormal_cellular_replicative1.55691740
39MP0004142_abnormal_muscle_tone1.54916349
40MP0005551_abnormal_eye_electrophysiolog1.51212909
41MP0005645_abnormal_hypothalamus_physiol1.51069925
42MP0002396_abnormal_hematopoietic_system1.50828761
43MP0010386_abnormal_urinary_bladder1.44709433
44MP0003123_paternal_imprinting1.43283763
45MP0002736_abnormal_nociception_after1.43086038
46MP0005084_abnormal_gallbladder_morpholo1.41778016
47MP0003136_yellow_coat_color1.40666968
48MP0005379_endocrine/exocrine_gland_phen1.39716994
49MP0005266_abnormal_metabolism1.38514363
50MP0002638_abnormal_pupillary_reflex1.37630417
51MP0000749_muscle_degeneration1.35590897
52MP0005332_abnormal_amino_acid1.31655289
53MP0003880_abnormal_central_pattern1.30176576
54MP0002090_abnormal_vision1.28757414
55MP0004084_abnormal_cardiac_muscle1.27484398
56MP0004215_abnormal_myocardial_fiber1.26957602
57MP0003137_abnormal_impulse_conducting1.26679615
58MP0003890_abnormal_embryonic-extraembry1.26285640
59MP0005670_abnormal_white_adipose1.24263637
60MP0001485_abnormal_pinna_reflex1.24259134
61MP0002102_abnormal_ear_morphology1.22918102
62MP0001835_abnormal_antigen_presentation1.21238548
63MP0002234_abnormal_pharynx_morphology1.21235386
64MP0005187_abnormal_penis_morphology1.18865369
65MP0004147_increased_porphyrin_level1.18442699
66MP0009785_altered_susceptibility_to1.17049318
67MP0000358_abnormal_cell_content/1.14916964
68MP0009046_muscle_twitch1.14510167
69MP0008995_early_reproductive_senescence1.14245985
70MP0003122_maternal_imprinting1.13425588
71MP0005671_abnormal_response_to1.12047652
72MP0005499_abnormal_olfactory_system1.10874469
73MP0005394_taste/olfaction_phenotype1.10874469
74MP0004036_abnormal_muscle_relaxation1.09974667
75MP0002332_abnormal_exercise_endurance1.09554207
76MP0002148_abnormal_hypersensitivity_rea1.09172578
77MP0002909_abnormal_adrenal_gland1.06067863
78MP0003567_abnormal_fetal_cardiomyocyte1.03310283
79MP0003787_abnormal_imprinting1.02828373
80MP0001853_heart_inflammation1.02657170
81MP0000015_abnormal_ear_pigmentation1.01380600
82MP0000049_abnormal_middle_ear1.00093649
83MP0002822_catalepsy0.98995018
84MP0005451_abnormal_body_composition0.97921908
85MP0001968_abnormal_touch/_nociception0.96841027
86MP0004133_heterotaxia0.95980355
87MP0000490_abnormal_crypts_of0.95841259
88MP0005376_homeostasis/metabolism_phenot0.95812126
89MP0009745_abnormal_behavioral_response0.95293378
90MP0005620_abnormal_muscle_contractility0.95077726
91MP0003221_abnormal_cardiomyocyte_apopto0.94600950
92MP0000013_abnormal_adipose_tissue0.92752098
93MP0009333_abnormal_splenocyte_physiolog0.92268871
94MP0002210_abnormal_sex_determination0.91849070
95MP0002972_abnormal_cardiac_muscle0.90851223
96MP0004085_abnormal_heartbeat0.90248718
97MP0001293_anophthalmia0.89866484
98MP0002160_abnormal_reproductive_system0.89196170
99MP0000631_abnormal_neuroendocrine_gland0.88157894
100MP0000647_abnormal_sebaceous_gland0.87387981
101MP0005171_absent_coat_pigmentation0.87005435
102MP0004270_analgesia0.85137298
103MP0003950_abnormal_plasma_membrane0.83330996
104MP0002734_abnormal_mechanical_nocicepti0.82564702
105MP0002876_abnormal_thyroid_physiology0.82039628
106MP0000313_abnormal_cell_death0.81930054
107MP0000751_myopathy0.81393973
108MP0002735_abnormal_chemical_nociception0.80936722
109MP0005389_reproductive_system_phenotype0.79537846
110MP0005636_abnormal_mineral_homeostasis0.79102038
111MP0005330_cardiomyopathy0.79074743
112MP0002277_abnormal_respiratory_mucosa0.76674307
113MP0002295_abnormal_pulmonary_circulatio0.76252413
114MP0008872_abnormal_physiological_respon0.76080933
115MP0002019_abnormal_tumor_incidence0.76010662
116MP0000516_abnormal_urinary_system0.75630078
117MP0005367_renal/urinary_system_phenotyp0.75630078
118MP0001119_abnormal_female_reproductive0.74899578
119MP0001929_abnormal_gametogenesis0.74870082
120MP0000689_abnormal_spleen_morphology0.74452974
121MP0008775_abnormal_heart_ventricle0.74162078
122MP0001486_abnormal_startle_reflex0.73843866
123MP0002095_abnormal_skin_pigmentation0.72657476
124MP0003011_delayed_dark_adaptation0.72404559
125MP0003656_abnormal_erythrocyte_physiolo0.71297105
126MP0001145_abnormal_male_reproductive0.70621750
127MP0001727_abnormal_embryo_implantation0.70218725
128MP0002751_abnormal_autonomic_nervous0.69734170
129MP0001542_abnormal_bone_strength0.67488465
130MP0005646_abnormal_pituitary_gland0.67474040
131MP0003315_abnormal_perineum_morphology0.67243647
132MP0003121_genomic_imprinting0.67046368
133MP0000653_abnormal_sex_gland0.66818169
134MP0002127_abnormal_cardiovascular_syste0.66421379
135MP0002106_abnormal_muscle_physiology0.65751703
136MP0000350_abnormal_cell_proliferation0.64968240
137MP0005408_hypopigmentation0.64043945
138MP0002272_abnormal_nervous_system0.63941965
139MP0002938_white_spotting0.63732382
140MP0003724_increased_susceptibility_to0.63690332
141MP0004381_abnormal_hair_follicle0.63110223
142MP0003763_abnormal_thymus_physiology0.62348973
143MP0002398_abnormal_bone_marrow0.60793021
144MP0002722_abnormal_immune_system0.60000405
145MP0001440_abnormal_grooming_behavior0.59178861

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)6.02465043
2Abnormal mitochondria in muscle tissue (HP:0008316)5.69069500
3Mitochondrial inheritance (HP:0001427)5.54451475
4Hepatocellular necrosis (HP:0001404)5.31698565
5Increased CSF lactate (HP:0002490)5.07110251
6Acute encephalopathy (HP:0006846)4.93651319
7Hepatic necrosis (HP:0002605)4.84794518
8Progressive macrocephaly (HP:0004481)4.84665031
9Increased hepatocellular lipid droplets (HP:0006565)4.27684647
10Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.98083465
11Lipid accumulation in hepatocytes (HP:0006561)3.90975836
12Increased serum lactate (HP:0002151)3.87810615
133-Methylglutaconic aciduria (HP:0003535)3.87172841
14Abnormality of glycolysis (HP:0004366)3.81122753
15Increased serum pyruvate (HP:0003542)3.81122753
16Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.75542149
17Cerebral edema (HP:0002181)3.65355838
18Exercise intolerance (HP:0003546)3.64088338
19* Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.57864694
20* Decreased activity of mitochondrial respiratory chain (HP:0008972)3.57864694
21* Lactic acidosis (HP:0003128)3.57783285
22Renal Fanconi syndrome (HP:0001994)3.54398911
23Birth length less than 3rd percentile (HP:0003561)3.49199680
24Microvesicular hepatic steatosis (HP:0001414)3.43486271
25Increased intramyocellular lipid droplets (HP:0012240)3.38848522
26* Respiratory failure (HP:0002878)3.31976025
27Methylmalonic acidemia (HP:0002912)3.24314507
28Exertional dyspnea (HP:0002875)3.23058681
29Cerebral hypomyelination (HP:0006808)3.03362775
30Increased muscle lipid content (HP:0009058)2.97382711
31Optic disc pallor (HP:0000543)2.97200383
32Reticulocytopenia (HP:0001896)2.91334213
33Respiratory difficulties (HP:0002880)2.85974584
34Abnormality of cells of the erythroid lineage (HP:0012130)2.82475925
35Leukodystrophy (HP:0002415)2.82287907
36Abnormal number of erythroid precursors (HP:0012131)2.81038071
37Type I transferrin isoform profile (HP:0003642)2.77481323
38Hypoglycemic coma (HP:0001325)2.74434774
39Aplastic anemia (HP:0001915)2.72700431
40Abnormality of alanine metabolism (HP:0010916)2.69474178
41Hyperalaninemia (HP:0003348)2.69474178
42Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.69474178
43Colon cancer (HP:0003003)2.65578999
44CNS demyelination (HP:0007305)2.64582766
45Type 2 muscle fiber atrophy (HP:0003554)2.57880788
46Hypothermia (HP:0002045)2.56222200
47Abnormality of midbrain morphology (HP:0002418)2.53917631
48Molar tooth sign on MRI (HP:0002419)2.53917631
49Chromosomal breakage induced by crosslinking agents (HP:0003221)2.44953374
50Chromsome breakage (HP:0040012)2.40688263
51Emotional lability (HP:0000712)2.37527605
52Hyperglycinemia (HP:0002154)2.36894431
53Hyperinsulinemic hypoglycemia (HP:0000825)2.36727245
54Hypoglycemic seizures (HP:0002173)2.35378757
55Generalized aminoaciduria (HP:0002909)2.30835797
56Carpal bone hypoplasia (HP:0001498)2.26791985
57Exercise-induced muscle cramps (HP:0003710)2.26732539
58Muscle fiber atrophy (HP:0100295)2.25958876
59Nemaline bodies (HP:0003798)2.20200356
60Breast hypoplasia (HP:0003187)2.20197383
61Abnormality of renal resorption (HP:0011038)2.19087209
62Oral leukoplakia (HP:0002745)2.15024229
63X-linked dominant inheritance (HP:0001423)2.14043006
64Pancreatic fibrosis (HP:0100732)2.12823472
65Abnormality of vitamin B metabolism (HP:0004340)2.11837475
66Amniotic constriction ring (HP:0009775)2.10619716
67Abnormality of placental membranes (HP:0011409)2.10619716
68* Lethargy (HP:0001254)2.10503913
69Abnormality of serum amino acid levels (HP:0003112)2.10130317
70Muscle fiber inclusion bodies (HP:0100299)2.09267008
71Gait imbalance (HP:0002141)2.07482897
72Macrocytic anemia (HP:0001972)2.06526706
73Abnormality of the preputium (HP:0100587)2.04391292
74Aplasia/Hypoplasia of the fovea (HP:0008060)2.03212918
75Hypoplasia of the fovea (HP:0007750)2.03212918
76Abnormal hair whorl (HP:0010721)2.01292065
77Nephronophthisis (HP:0000090)2.01288807
78Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.99943361
79Duplicated collecting system (HP:0000081)1.99679390
80Abnormality of methionine metabolism (HP:0010901)1.99173236
81Renal cortical cysts (HP:0000803)1.97690845
82Medial flaring of the eyebrow (HP:0010747)1.94437941
83Abnormality of aspartate family amino acid metabolism (HP:0010899)1.93731351
84Abnormality of the fovea (HP:0000493)1.92089264
85Neuroendocrine neoplasm (HP:0100634)1.91347851
86Pallor (HP:0000980)1.90927897
87Unsteady gait (HP:0002317)1.90527704
88Pancreatic cysts (HP:0001737)1.89298040
89Pancytopenia (HP:0001876)1.88417755
90Neoplasm of the adrenal gland (HP:0100631)1.87658808
91True hermaphroditism (HP:0010459)1.87167381
92Gliosis (HP:0002171)1.86829566
93Delayed gross motor development (HP:0002194)1.84706636
94Ragged-red muscle fibers (HP:0003200)1.84631594
95Pancreatic islet-cell hyperplasia (HP:0004510)1.83978982
96Hyperglycinuria (HP:0003108)1.83637378
97Megaloblastic anemia (HP:0001889)1.83137508
98Abnormality of urine glucose concentration (HP:0011016)1.82759719
99Glycosuria (HP:0003076)1.82759719
100Nephrogenic diabetes insipidus (HP:0009806)1.82008172
101Dicarboxylic aciduria (HP:0003215)1.81992901
102Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81992901
103IgM deficiency (HP:0002850)1.81604021
104Methylmalonic aciduria (HP:0012120)1.81576167
105Agnosia (HP:0010524)1.80637530
106Hyperphosphaturia (HP:0003109)1.79951360
107Abnormality of the renal collecting system (HP:0004742)1.79934269
108Abnormality of aromatic amino acid family metabolism (HP:0004338)1.79683317
109Abnormality of the vitamin B12 metabolism (HP:0004341)1.79620234
110Intestinal atresia (HP:0011100)1.79556233
111Rimmed vacuoles (HP:0003805)1.79302434
112Progressive external ophthalmoplegia (HP:0000590)1.79234104
113CNS hypomyelination (HP:0003429)1.78868550
114Palpitations (HP:0001962)1.78397098
115Abnormality of serine family amino acid metabolism (HP:0010894)1.77723275
116Abnormality of glycine metabolism (HP:0010895)1.77723275
117Reduced antithrombin III activity (HP:0001976)1.76607049
118Meckel diverticulum (HP:0002245)1.74990835
119Progressive inability to walk (HP:0002505)1.74253947
120Abnormality of the ileum (HP:0001549)1.73123819
121Aplasia/Hypoplasia of the sacrum (HP:0008517)1.72989366
122Abnormality of the heme biosynthetic pathway (HP:0010472)1.72908346
123Congenital primary aphakia (HP:0007707)1.72349774
124Abnormality of the anterior horn cell (HP:0006802)1.72144561
125Degeneration of anterior horn cells (HP:0002398)1.72144561
126Aplasia/Hypoplasia involving the musculature (HP:0001460)1.71304716
127Abnormality of the labia minora (HP:0012880)1.71069358
128Genital tract atresia (HP:0001827)1.70799720
129Ketoacidosis (HP:0001993)1.70743024
130Nausea (HP:0002018)1.69345416
131Congenital malformation of the right heart (HP:0011723)1.66947548
132Double outlet right ventricle (HP:0001719)1.66947548
133Median cleft lip (HP:0000161)1.66604255
134Esophageal neoplasm (HP:0100751)1.66432233
135Neoplasm of head and neck (HP:0012288)1.66432233
136Blindness (HP:0000618)1.66060466
137Poor suck (HP:0002033)1.65929749
138Absent thumb (HP:0009777)1.65696261
139Abolished electroretinogram (ERG) (HP:0000550)1.65646989
140Abnormal protein glycosylation (HP:0012346)1.64632154
141Abnormal glycosylation (HP:0012345)1.64632154
142Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.64632154
143Abnormal protein N-linked glycosylation (HP:0012347)1.64632154

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK163.91419854
2BUB13.43753276
3VRK23.09659991
4WEE12.90026671
5MAP3K122.85420854
6NME22.79099598
7TRIM282.78045585
8EIF2AK12.57463733
9VRK12.48909658
10NME12.41983653
11FRK2.38155492
12EIF2AK32.22429194
13ARAF2.22398482
14WNK32.22064222
15TSSK62.21945327
16CASK2.07489425
17PIM22.00685634
18CDC71.92533251
19MAP4K21.92174395
20NUAK11.90799778
21SRPK11.90635897
22CDK81.90316052
23MUSK1.80574484
24MYLK1.70049875
25PHKG11.69950849
26PHKG21.69950849
27PLK41.69585564
28CCNB11.59881235
29PBK1.58107952
30BRAF1.56400414
31ZAK1.52248751
32MAP3K41.51617363
33GRK11.48913425
34CSNK1G11.46938731
35GRK71.46879658
36NEK11.42560380
37AKT31.30286136
38STK391.28168940
39BMPR1B1.27110263
40ADRBK21.25481841
41CSNK1G21.23861787
42BCKDK1.22819898
43BRSK21.19701360
44PLK11.19653724
45INSRR1.15748576
46PDK41.15485519
47PDK31.15485519
48ERBB31.15128618
49PLK31.13748057
50MAP2K71.10680744
51TNIK1.07521983
52EIF2AK21.07465037
53IRAK41.06623156
54PDK21.06533190
55MKNK11.06401654
56SIK31.03094614
57CSNK1A1L1.01601260
58DAPK10.99737488
59BMPR20.98943201
60MAPKAPK50.98334358
61TESK20.98192347
62TAF10.96663652
63MST40.96589131
64MKNK20.94121659
65OXSR10.91828519
66DYRK20.91288738
67MAPKAPK30.91047428
68PAK30.90431326
69AURKA0.89076204
70OBSCN0.88517734
71ACVR1B0.88363666
72CDK190.86482393
73YES10.84382695
74GRK50.83540544
75TLK10.82459407
76STK240.82108974
77RPS6KB20.79420016
78CDK70.79369298
79PRKCE0.78974282
80TXK0.77052441
81WNK40.76736796
82TTK0.75005879
83PRKCG0.74281315
84CSNK2A10.73905382
85STK38L0.71783728
86IRAK30.70588959
87ATR0.70004251
88SCYL20.69357731
89PLK20.68583906
90MAPK130.68116305
91ABL20.67633985
92TIE10.66951949
93MINK10.65810697
94MARK10.64856941
95TEC0.64333637
96BRSK10.62989910
97AURKB0.62934535
98CSNK2A20.60154375
99BLK0.59239561
100MAP3K110.57080030
101RPS6KA50.56201517
102PRKG20.56103172
103KIT0.55761348
104CHEK20.55674130
105PINK10.55378340
106FLT30.54291504
107CAMK2A0.52442675
108PNCK0.49470925
109ILK0.48731738
110CSNK1G30.48117467
111LIMK10.47653449
112PIM10.46593359
113CSNK1A10.46224678
114MOS0.45051601
115CAMK2D0.44583485
116PRKACA0.44518510
117DYRK30.44271954
118DAPK30.43841555
119NEK90.43394055
120RPS6KA60.43134232
121PRKG10.42738269
122CAMKK20.41059774
123TRPM70.39468781
124NLK0.39276440
125STK40.39171397
126EPHA20.38593462
127TESK10.36910354
128ATM0.36782404
129TGFBR10.36291290
130PRKCI0.35919932
131SYK0.34891739
132MAP2K60.34799003
133PAK10.34563366
134EPHA40.34021997
135IKBKB0.33538838
136MAP4K10.32960051
137MAP3K60.32335106
138BCR0.32130649
139LYN0.31034287
140ADRBK10.30672419
141MATK0.30067102

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.42934881
2Oxidative phosphorylation_Homo sapiens_hsa001904.26558747
3Parkinsons disease_Homo sapiens_hsa050123.76227134
4RNA polymerase_Homo sapiens_hsa030203.72853344
5Ribosome_Homo sapiens_hsa030103.70616531
6DNA replication_Homo sapiens_hsa030303.11337313
7Mismatch repair_Homo sapiens_hsa034303.07820683
8Huntingtons disease_Homo sapiens_hsa050162.83341470
9Alzheimers disease_Homo sapiens_hsa050102.55702350
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.50260502
11Pyrimidine metabolism_Homo sapiens_hsa002402.41286549
12Homologous recombination_Homo sapiens_hsa034402.30795613
13Nucleotide excision repair_Homo sapiens_hsa034202.23822194
14Protein export_Homo sapiens_hsa030602.20608602
15Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.15412032
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.14137509
17Base excision repair_Homo sapiens_hsa034102.06993328
18Spliceosome_Homo sapiens_hsa030401.93811168
19Basal transcription factors_Homo sapiens_hsa030221.86774244
20Butanoate metabolism_Homo sapiens_hsa006501.66788402
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.64210585
22RNA transport_Homo sapiens_hsa030131.62858284
23Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54524145
24Purine metabolism_Homo sapiens_hsa002301.53434609
25RNA degradation_Homo sapiens_hsa030181.49187478
26Fanconi anemia pathway_Homo sapiens_hsa034601.45363199
27Cardiac muscle contraction_Homo sapiens_hsa042601.40528965
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.34281984
29One carbon pool by folate_Homo sapiens_hsa006701.33209426
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.31947989
31Sulfur metabolism_Homo sapiens_hsa009201.29732825
322-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.24658332
33Cell cycle_Homo sapiens_hsa041101.21158357
34Collecting duct acid secretion_Homo sapiens_hsa049661.20813950
35Non-homologous end-joining_Homo sapiens_hsa034501.19105566
36Steroid biosynthesis_Homo sapiens_hsa001001.18667440
37Fatty acid degradation_Homo sapiens_hsa000711.14745251
38Folate biosynthesis_Homo sapiens_hsa007901.13370583
39Fatty acid elongation_Homo sapiens_hsa000621.12747801
40Fatty acid metabolism_Homo sapiens_hsa012121.11830227
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.08334654
42Vitamin B6 metabolism_Homo sapiens_hsa007501.08174695
43Tryptophan metabolism_Homo sapiens_hsa003801.06899795
44Cysteine and methionine metabolism_Homo sapiens_hsa002700.95290267
45Pyruvate metabolism_Homo sapiens_hsa006200.94527234
46Primary bile acid biosynthesis_Homo sapiens_hsa001200.93350102
47Carbon metabolism_Homo sapiens_hsa012000.92919271
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92136113
49Metabolic pathways_Homo sapiens_hsa011000.86927916
50Regulation of autophagy_Homo sapiens_hsa041400.85837144
51Selenocompound metabolism_Homo sapiens_hsa004500.83053429
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83025218
53Biosynthesis of amino acids_Homo sapiens_hsa012300.79554670
54Pentose and glucuronate interconversions_Homo sapiens_hsa000400.78733685
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78649852
56Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.78434846
57Nitrogen metabolism_Homo sapiens_hsa009100.78275095
58Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.77992043
59Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.77032305
60Glutathione metabolism_Homo sapiens_hsa004800.75406172
61Arachidonic acid metabolism_Homo sapiens_hsa005900.74594778
62Fructose and mannose metabolism_Homo sapiens_hsa000510.72341166
63Epstein-Barr virus infection_Homo sapiens_hsa051690.72246684
64Pentose phosphate pathway_Homo sapiens_hsa000300.70852349
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.69051416
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.67303258
67Retinol metabolism_Homo sapiens_hsa008300.61965300
68Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.61756040
69Propanoate metabolism_Homo sapiens_hsa006400.61365016
70Chemical carcinogenesis_Homo sapiens_hsa052040.61237956
71Vibrio cholerae infection_Homo sapiens_hsa051100.60476022
72Caffeine metabolism_Homo sapiens_hsa002320.60200601
73Drug metabolism - other enzymes_Homo sapiens_hsa009830.59743744
74Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.58568284
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57915520
76Phototransduction_Homo sapiens_hsa047440.54722059
77Fat digestion and absorption_Homo sapiens_hsa049750.54573396
78Arginine and proline metabolism_Homo sapiens_hsa003300.54105014
79Cyanoamino acid metabolism_Homo sapiens_hsa004600.53892516
80p53 signaling pathway_Homo sapiens_hsa041150.52128688
81Other glycan degradation_Homo sapiens_hsa005110.51773622
82Rheumatoid arthritis_Homo sapiens_hsa053230.49383976
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48623683
84Peroxisome_Homo sapiens_hsa041460.47928688
85Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.46103777
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45973089
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.44670282
88Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43646053
89Phenylalanine metabolism_Homo sapiens_hsa003600.43069336
90Tyrosine metabolism_Homo sapiens_hsa003500.42583744
91mRNA surveillance pathway_Homo sapiens_hsa030150.41181878
92Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41096882
93N-Glycan biosynthesis_Homo sapiens_hsa005100.37673949
94Circadian rhythm_Homo sapiens_hsa047100.36703326
95Legionellosis_Homo sapiens_hsa051340.35467520
96Starch and sucrose metabolism_Homo sapiens_hsa005000.33943495
97Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.33560033
98Galactose metabolism_Homo sapiens_hsa000520.33525596
99Insulin secretion_Homo sapiens_hsa049110.32866841
100Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.32169438
101GABAergic synapse_Homo sapiens_hsa047270.31462511
102Linoleic acid metabolism_Homo sapiens_hsa005910.30890620
103Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.29869074
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.28073801
105Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.27390950
106Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.26805551
107Phagosome_Homo sapiens_hsa041450.26005154
108Synaptic vesicle cycle_Homo sapiens_hsa047210.25028998
109Sulfur relay system_Homo sapiens_hsa041220.23483233
110Graft-versus-host disease_Homo sapiens_hsa053320.22065443
111Asthma_Homo sapiens_hsa053100.20863492
112beta-Alanine metabolism_Homo sapiens_hsa004100.20477524
113Oocyte meiosis_Homo sapiens_hsa041140.20007086
114Allograft rejection_Homo sapiens_hsa053300.18910920
115Herpes simplex infection_Homo sapiens_hsa051680.17715546
116Type I diabetes mellitus_Homo sapiens_hsa049400.17500550
117Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.16385440
118Histidine metabolism_Homo sapiens_hsa003400.14660234
119Primary immunodeficiency_Homo sapiens_hsa053400.13565657
120Ether lipid metabolism_Homo sapiens_hsa005650.12905874
121Nicotine addiction_Homo sapiens_hsa050330.12854028
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12787517
123Antigen processing and presentation_Homo sapiens_hsa046120.12786691
124Hematopoietic cell lineage_Homo sapiens_hsa046400.12036962
125alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.12026488
126Systemic lupus erythematosus_Homo sapiens_hsa053220.11039305
127Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.10355025

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