NFX1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro. The protein may play a role in regulating the duration of an inflammatory response by limiting the period in which class II MHC molecules are induced by IFN-gamma. Three alternative splice variants, each of which encodes a different isoform, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1monoubiquitinated protein deubiquitination (GO:0035520)5.64133628
2IMP biosynthetic process (GO:0006188)5.48791837
3protein K11-linked deubiquitination (GO:0035871)5.30945152
4DNA unwinding involved in DNA replication (GO:0006268)5.23688818
5interkinetic nuclear migration (GO:0022027)5.23652276
6cilium or flagellum-dependent cell motility (GO:0001539)5.04679675
7nuclear pore organization (GO:0006999)5.02436422
8nucleobase biosynthetic process (GO:0046112)5.00271028
9DNA replication initiation (GO:0006270)4.86117088
10indolalkylamine metabolic process (GO:0006586)4.82787639
11kynurenine metabolic process (GO:0070189)4.81155309
12folic acid-containing compound biosynthetic process (GO:0009396)4.80978384
13tryptophan catabolic process (GO:0006569)4.71223729
14indole-containing compound catabolic process (GO:0042436)4.71223729
15indolalkylamine catabolic process (GO:0046218)4.71223729
16histone H3-K4 trimethylation (GO:0080182)4.67304952
17nuclear pore complex assembly (GO:0051292)4.65084767
18purine nucleobase biosynthetic process (GO:0009113)4.57755760
19IMP metabolic process (GO:0046040)4.37758981
20cellular ketone body metabolic process (GO:0046950)4.33088062
21DNA strand elongation involved in DNA replication (GO:0006271)4.29934659
22DNA strand elongation (GO:0022616)4.22780166
23telomere maintenance via semi-conservative replication (GO:0032201)4.12573374
24rRNA catabolic process (GO:0016075)4.10692599
25DNA duplex unwinding (GO:0032508)4.08715489
26snRNA transcription (GO:0009301)4.07296302
27pre-miRNA processing (GO:0031054)4.06978770
28DNA geometric change (GO:0032392)4.06882808
29cell wall macromolecule catabolic process (GO:0016998)4.06144877
30mitotic nuclear envelope disassembly (GO:0007077)4.03833721
31photoreceptor cell maintenance (GO:0045494)3.94772964
32phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.86785601
33tryptophan metabolic process (GO:0006568)3.86779648
34somatic diversification of immune receptors via somatic mutation (GO:0002566)3.82897365
35somatic hypermutation of immunoglobulin genes (GO:0016446)3.82897365
36regulation of helicase activity (GO:0051095)3.82483721
37UDP-N-acetylglucosamine metabolic process (GO:0006047)3.80672149
38histone H2A acetylation (GO:0043968)3.80171422
39protein K48-linked deubiquitination (GO:0071108)3.79112161
40protein localization to kinetochore (GO:0034501)3.78753916
41meiotic chromosome segregation (GO:0045132)3.77459106
42ketone body metabolic process (GO:1902224)3.77348217
43regulation of DNA damage checkpoint (GO:2000001)3.76637946
44viral mRNA export from host cell nucleus (GO:0046784)3.74694276
45membrane disassembly (GO:0030397)3.74178080
46nuclear envelope disassembly (GO:0051081)3.74178080
47negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.73508820
48mitotic recombination (GO:0006312)3.70676010
49regulation of DNA endoreduplication (GO:0032875)3.70659448
50ribosome biogenesis (GO:0042254)3.69084299
51DNA replication-dependent nucleosome organization (GO:0034723)3.68639560
52DNA replication-dependent nucleosome assembly (GO:0006335)3.68639560
53negative regulation of histone methylation (GO:0031061)3.68234483
54mitotic sister chromatid cohesion (GO:0007064)3.68192336
55telomere maintenance via recombination (GO:0000722)3.66052160
56dosage compensation (GO:0007549)3.65633608
57drug catabolic process (GO:0042737)3.64922540
58cell wall macromolecule metabolic process (GO:0044036)3.59895724
59ribosomal small subunit assembly (GO:0000028)3.54040023
60signal peptide processing (GO:0006465)3.52561941
61regulation of cilium movement (GO:0003352)3.51585304
62epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.49871568
63spliceosomal tri-snRNP complex assembly (GO:0000244)3.48724655
64detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.48331913
65maturation of SSU-rRNA (GO:0030490)3.48201184
66telomere maintenance via telomere lengthening (GO:0010833)3.47823952
67detection of light stimulus involved in visual perception (GO:0050908)3.46030386
68detection of light stimulus involved in sensory perception (GO:0050962)3.46030386
69snRNA processing (GO:0016180)3.43431665
70postreplication repair (GO:0006301)3.42921216
71L-fucose catabolic process (GO:0042355)3.42632380
72fucose catabolic process (GO:0019317)3.42632380
73L-fucose metabolic process (GO:0042354)3.42632380
74regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.42107767
75regulation of histone H3-K9 methylation (GO:0051570)3.40841236
76establishment of protein localization to Golgi (GO:0072600)3.40284317
77positive regulation of defense response to virus by host (GO:0002230)3.37933101
78oxidative demethylation (GO:0070989)3.37484732
79peptidyl-lysine trimethylation (GO:0018023)3.37043856
80pore complex assembly (GO:0046931)3.35511345
81regulation of hippo signaling (GO:0035330)3.34960724
82RNA export from nucleus (GO:0006405)3.34289233
83mRNA export from nucleus (GO:0006406)3.33974763
84intra-S DNA damage checkpoint (GO:0031573)3.33843454
85nucleotide-excision repair, DNA gap filling (GO:0006297)3.33638354
86regulation of translational fidelity (GO:0006450)3.32792957
87translesion synthesis (GO:0019985)3.32414561
88regulation of nuclear cell cycle DNA replication (GO:0033262)3.32228104
89regulation of spindle organization (GO:0090224)3.32169352
90sister chromatid segregation (GO:0000819)3.28673261
91telomere maintenance (GO:0000723)3.27177924
92negative regulation of RNA splicing (GO:0033119)3.25360074
93protein K63-linked deubiquitination (GO:0070536)3.25274027
94telomere organization (GO:0032200)3.24116744
95axonemal dynein complex assembly (GO:0070286)3.23672793
96NAD biosynthetic process (GO:0009435)3.22389579
97snRNA metabolic process (GO:0016073)3.21693052
98peptidyl-lysine methylation (GO:0018022)3.21086000
99formation of translation preinitiation complex (GO:0001731)3.19979423
100DNA conformation change (GO:0071103)3.19187001
101axoneme assembly (GO:0035082)3.18002429
102mRNA transport (GO:0051028)3.17865444
103mitotic sister chromatid segregation (GO:0000070)3.17752684
104poly(A)+ mRNA export from nucleus (GO:0016973)3.16865621
105cellular response to ethanol (GO:0071361)3.15378563
106regulation of memory T cell differentiation (GO:0043380)3.14980091
107indole-containing compound metabolic process (GO:0042430)3.14771513
108chromatin remodeling at centromere (GO:0031055)3.13946588
109protein localization to chromosome, centromeric region (GO:0071459)3.12514247
110positive regulation of developmental pigmentation (GO:0048087)3.11489283
111nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.11350690
112mismatch repair (GO:0006298)3.10866732
113mitotic chromosome condensation (GO:0007076)3.10503700
114DNA replication checkpoint (GO:0000076)3.10275249
115cilium movement (GO:0003341)3.09966164
116CENP-A containing nucleosome assembly (GO:0034080)3.09097722
117DNA replication-independent nucleosome organization (GO:0034724)3.08600403
118DNA replication-independent nucleosome assembly (GO:0006336)3.08600403
119histone H4-K5 acetylation (GO:0043981)3.06793586
120histone H4-K8 acetylation (GO:0043982)3.06793586
121mRNA splice site selection (GO:0006376)3.06288554
122auditory receptor cell stereocilium organization (GO:0060088)3.05422150
123histone H3-K9 methylation (GO:0051567)3.04433921
124exogenous drug catabolic process (GO:0042738)3.03772150
125DNA topological change (GO:0006265)3.03672172
126mRNA splicing, via spliceosome (GO:0000398)3.03295274
127RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.03295274
128RNA splicing, via transesterification reactions (GO:0000375)3.03164169
129negative regulation of mRNA processing (GO:0050686)3.02047676
130benzene-containing compound metabolic process (GO:0042537)3.01893610
131neural tube formation (GO:0001841)3.00146306
132nonmotile primary cilium assembly (GO:0035058)2.98627529
133tRNA aminoacylation for protein translation (GO:0006418)2.97677071
134tachykinin receptor signaling pathway (GO:0007217)2.97521388
135mitotic metaphase plate congression (GO:0007080)2.97441941
136regulation of mitotic spindle organization (GO:0060236)2.97007307
137regulation of centriole replication (GO:0046599)2.96935413
138methionine biosynthetic process (GO:0009086)2.95445984
139reciprocal meiotic recombination (GO:0007131)2.95101313
140reciprocal DNA recombination (GO:0035825)2.95101313
141establishment of RNA localization (GO:0051236)2.94087946
142nucleic acid transport (GO:0050657)2.94087946
143RNA transport (GO:0050658)2.94087946
144regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.93609949
145peptidyl-threonine dephosphorylation (GO:0035970)2.93011252
146lipid translocation (GO:0034204)2.92747486
147phospholipid translocation (GO:0045332)2.92747486
148tRNA aminoacylation (GO:0043039)2.92550936
149amino acid activation (GO:0043038)2.92550936
150epithelial cilium movement (GO:0003351)2.92013756
151regulation of gene silencing by RNA (GO:0060966)2.91723889
152regulation of posttranscriptional gene silencing (GO:0060147)2.91723889
153regulation of gene silencing by miRNA (GO:0060964)2.91723889
154nucleus localization (GO:0051647)2.91608082
155regulation of centrosome cycle (GO:0046605)2.90757536
156peptidyl-arginine omega-N-methylation (GO:0035247)2.90219094
157cilium assembly (GO:0042384)2.90095273
158nuclear export (GO:0051168)2.89499983
159cilium organization (GO:0044782)2.89251963
160tetrahydrofolate metabolic process (GO:0046653)2.86922217
161regulation of translational termination (GO:0006449)2.86778982
162protein polyglutamylation (GO:0018095)2.81996027
163fibroblast migration (GO:0010761)2.81985252
164metaphase plate congression (GO:0051310)2.81515218
165regulation of telomere maintenance via telomerase (GO:0032210)2.81030210
166spliceosomal snRNP assembly (GO:0000387)2.80622699
167histone H3-K9 modification (GO:0061647)2.79842953
168microtubule anchoring (GO:0034453)2.78675727
169double-strand break repair via homologous recombination (GO:0000724)2.78282757
170L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.78149404
171cellular biogenic amine catabolic process (GO:0042402)2.77695958
172amine catabolic process (GO:0009310)2.77695958
173cilium morphogenesis (GO:0060271)2.77683808
174motile cilium assembly (GO:0044458)2.74762836
175cellular response to sterol (GO:0036315)2.74727567
176reflex (GO:0060004)2.74039980
177thyroid hormone metabolic process (GO:0042403)2.73016162
178negative regulation of mast cell activation (GO:0033004)2.72802375
179myelin assembly (GO:0032288)2.72604743
180recombinational repair (GO:0000725)2.72343656
181sphingoid metabolic process (GO:0046519)2.72200279
182regulation of sarcomere organization (GO:0060297)2.71821777
183regulation of establishment of cell polarity (GO:2000114)2.71410350
184cellular response to exogenous dsRNA (GO:0071360)2.70975478
185macroautophagy (GO:0016236)2.68972478
186flavonoid metabolic process (GO:0009812)2.67605669
187behavioral response to nicotine (GO:0035095)2.67315356
188aromatic amino acid family catabolic process (GO:0009074)2.66923030
189regulation of pigment cell differentiation (GO:0050932)2.65078887
190histone lysine methylation (GO:0034968)2.64732573
191Golgi to endosome transport (GO:0006895)2.64190393
192interleukin-6-mediated signaling pathway (GO:0070102)2.61572234
193cellular component assembly involved in morphogenesis (GO:0010927)2.57408683
194iron ion import (GO:0097286)2.56514888
195regulation of translation, ncRNA-mediated (GO:0045974)2.54880186
196negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.54880186
197negative regulation of translation, ncRNA-mediated (GO:0040033)2.54880186
198cAMP catabolic process (GO:0006198)2.54748810

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_18555785_ChIP-Seq_MESCs_Mouse4.09588028
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.86998330
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.51335834
4GBX2_23144817_ChIP-Seq_PC3_Human3.50510834
5ZNF274_21170338_ChIP-Seq_K562_Hela3.11015594
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.08887694
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.98871791
8* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.95080164
9GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.90664895
10EGR1_19374776_ChIP-ChIP_THP-1_Human2.81630620
11* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.79083440
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.68732055
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.60533918
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.51795041
15YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.49479598
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.46100641
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.43335361
18E2F1_21310950_ChIP-Seq_MCF-7_Human2.42240453
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.41971498
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.38911459
21SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.37160352
22EST1_17652178_ChIP-ChIP_JURKAT_Human2.33582600
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32008289
24* MYC_22102868_ChIP-Seq_BL_Human2.30703245
25VDR_22108803_ChIP-Seq_LS180_Human2.27290475
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.26126398
27GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.24509990
28CIITA_25753668_ChIP-Seq_RAJI_Human2.22423681
29KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.16447388
30* PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.15847102
31TAF15_26573619_Chip-Seq_HEK293_Human2.13624342
32STAT3_23295773_ChIP-Seq_U87_Human2.13596141
33THAP11_20581084_ChIP-Seq_MESCs_Mouse2.13520349
34SALL1_21062744_ChIP-ChIP_HESCs_Human2.12298069
35* ETS1_20019798_ChIP-Seq_JURKAT_Human2.11745816
36AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.11683145
37CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09147481
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.07060063
39* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.04695854
40* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.04086752
41* VDR_23849224_ChIP-Seq_CD4+_Human2.02730777
42XRN2_22483619_ChIP-Seq_HELA_Human2.01320846
43E2F7_22180533_ChIP-Seq_HELA_Human10.4282766
44FOXP3_21729870_ChIP-Seq_TREG_Human1.99877205
45ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99787658
46IGF1R_20145208_ChIP-Seq_DFB_Human1.97913049
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97389243
48ER_23166858_ChIP-Seq_MCF-7_Human1.93331470
49GABP_17652178_ChIP-ChIP_JURKAT_Human1.92648701
50TCF4_23295773_ChIP-Seq_U87_Human1.90429647
51EWS_26573619_Chip-Seq_HEK293_Human1.89829996
52CBP_20019798_ChIP-Seq_JUKART_Human1.88853477
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.88853477
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.87754198
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86015662
56CREB1_15753290_ChIP-ChIP_HEK293T_Human1.83570389
57AR_21572438_ChIP-Seq_LNCaP_Human1.78551244
58EGR1_23403033_ChIP-Seq_LIVER_Mouse1.76294971
59SMAD4_21799915_ChIP-Seq_A2780_Human1.75714901
60TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.73872518
61NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71227512
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.71158321
63* GABP_19822575_ChIP-Seq_HepG2_Human1.68937396
64FUS_26573619_Chip-Seq_HEK293_Human1.68874067
65ZFX_18555785_ChIP-Seq_MESCs_Mouse1.66835492
66TP63_19390658_ChIP-ChIP_HaCaT_Human1.66297076
67KDM5A_27292631_Chip-Seq_BREAST_Human1.65283906
68CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64963785
69E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63543763
70SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.63513595
71PCGF2_27294783_Chip-Seq_NPCs_Mouse1.63459707
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.63390337
73PIAS1_25552417_ChIP-Seq_VCAP_Human1.63070776
74NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.61736135
75CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.60737317
76ESR1_15608294_ChIP-ChIP_MCF-7_Human1.60645903
77* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58748038
78ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54995903
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54864780
80BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52089476
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.51149970
82ELK1_19687146_ChIP-ChIP_HELA_Human1.50541873
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50202600
84PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50120215
85AR_21909140_ChIP-Seq_LNCAP_Human1.48840197
86TTF2_22483619_ChIP-Seq_HELA_Human1.48740001
87* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.48723771
88DROSHA_22980978_ChIP-Seq_HELA_Human1.48560048
89* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47954251
90PADI4_21655091_ChIP-ChIP_MCF-7_Human1.47499773
91P300_19829295_ChIP-Seq_ESCs_Human1.47166341
92* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.46918693
93TP53_16413492_ChIP-PET_HCT116_Human1.46457057
94UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.46150643
95SUZ12_27294783_Chip-Seq_NPCs_Mouse1.45888241
96DCP1A_22483619_ChIP-Seq_HELA_Human1.45074960
97* AHR_22903824_ChIP-Seq_MCF-7_Human1.43681254
98* CDX2_22108803_ChIP-Seq_LS180_Human1.43469002
99MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.43031029
100MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41331991
101AR_25329375_ChIP-Seq_VCAP_Human1.38511574
102FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.37683323
103IRF8_22096565_ChIP-ChIP_GC-B_Human1.36808118
104POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36248171
105* TFEB_21752829_ChIP-Seq_HELA_Human1.34412383
106SOX2_18555785_ChIP-Seq_MESCs_Mouse1.34083874
107* ARNT_22903824_ChIP-Seq_MCF-7_Human1.34035118
108* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33641061
109CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.33627807
110SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.33244827
111HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.32763946
112TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32633801
113POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.32633801
114EZH2_22144423_ChIP-Seq_EOC_Human1.31929440
115BCAT_22108803_ChIP-Seq_LS180_Human1.31157093
116NFE2_27457419_Chip-Seq_LIVER_Mouse1.30846779
117GATA1_22025678_ChIP-Seq_K562_Human1.30757521
118EZH2_27294783_Chip-Seq_NPCs_Mouse1.29044298
119* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28771913
120TCF4_22108803_ChIP-Seq_LS180_Human1.28591991
121ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.28530039
122MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.27777145
123SMAD4_21741376_ChIP-Seq_EPCs_Human1.27692324
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27632448
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.25900228
126EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25517871
127IRF1_19129219_ChIP-ChIP_H3396_Human1.24649042
128OCT4_21477851_ChIP-Seq_ESCs_Mouse1.23110238
129NANOG_21062744_ChIP-ChIP_HESCs_Human1.22727601
130HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.22019137
131CRX_20693478_ChIP-Seq_RETINA_Mouse1.21537988
132NOTCH1_21737748_ChIP-Seq_TLL_Human1.20923505
133PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.20476861
134KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20433986
135GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.20092232
136PRDM14_20953172_ChIP-Seq_ESCs_Human1.19258348
137FLI1_21867929_ChIP-Seq_TH2_Mouse1.19239272
138* TP53_22573176_ChIP-Seq_HFKS_Human1.19162215
139YY1_21170310_ChIP-Seq_MESCs_Mouse1.18835531
140TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.18716741
141RUNX2_22187159_ChIP-Seq_PCA_Human1.18544210
142* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17010823
143NANOG_18555785_Chip-Seq_ESCs_Mouse1.16383397
144ZNF217_24962896_ChIP-Seq_MCF-7_Human1.16334724
145POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.15725262
146SMRT_27268052_Chip-Seq_Bcells_Human1.15354891
147* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.15176163
148BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.12009352
149E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10945600
150SMAD3_21741376_ChIP-Seq_EPCs_Human1.10708743
151HOXB7_26014856_ChIP-Seq_BT474_Human1.10071700
152FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09768135
153SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.08768571
154FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08325640
155SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.07676771
156OCT1_27270436_Chip-Seq_PROSTATE_Human1.06438498
157EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.06162158
158FOXA1_21572438_ChIP-Seq_LNCaP_Human1.06000769
159TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04172191
160GATA3_26560356_Chip-Seq_TH2_Human1.04051172
161TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.03968602
162AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.03858698
163* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.02555182
164OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02454471
165SOX2_21211035_ChIP-Seq_LN229_Gbm1.02338092
166E2F1_18555785_Chip-Seq_ESCs_Mouse1.02163747
167ESR1_20079471_ChIP-ChIP_T-47D_Human1.01560314
168MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.01376951
169KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00308535
170SMAD_19615063_ChIP-ChIP_OVARY_Human0.99612251
171SRF_21415370_ChIP-Seq_HL-1_Mouse0.98980183
172TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.98671655
173SCL_19346495_ChIP-Seq_HPC-7_Human0.97278676
174STAT3_18555785_Chip-Seq_ESCs_Mouse0.95959007
175P300_18555785_Chip-Seq_ESCs_Mouse0.95652730
176SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95299646
177CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.94775498
178AR_19668381_ChIP-Seq_PC3_Human0.94750048
179DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.94656417
180SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.94230004
181PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92341029
182* DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.90873478
183NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.90724759
184HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.90267016
185VDR_21846776_ChIP-Seq_THP-1_Human0.90266391
186NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.89422743
187CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87497629
188STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.87059486
189SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.80201657
190IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.79552567
191MYB_26560356_Chip-Seq_TH1_Human0.79445161
192CHD1_26751641_Chip-Seq_LNCaP_Human0.78628837
193KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.78314109
194MYC_18940864_ChIP-ChIP_HL60_Human0.76550905
195ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.74562444
196NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.74450347

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.87416209
2MP0003111_abnormal_nucleus_morphology4.13938903
3MP0003195_calcinosis4.05514537
4MP0003693_abnormal_embryo_hatching3.97542125
5MP0004957_abnormal_blastocyst_morpholog3.83488931
6MP0003646_muscle_fatigue3.83340569
7MP0008058_abnormal_DNA_repair3.69378080
8MP0008057_abnormal_DNA_replication3.56181666
9MP0003077_abnormal_cell_cycle3.51472014
10MP0003123_paternal_imprinting3.25406088
11MP0008007_abnormal_cellular_replicative3.23431760
12MP0004043_abnormal_pH_regulation3.19099124
13MP0002396_abnormal_hematopoietic_system3.11025660
14MP0005310_abnormal_salivary_gland3.09996374
15MP0003787_abnormal_imprinting3.05898647
16MP0008877_abnormal_DNA_methylation2.78053986
17MP0003121_genomic_imprinting2.68551684
18MP0004147_increased_porphyrin_level2.63629121
19MP0005551_abnormal_eye_electrophysiolog2.59201603
20MP0002138_abnormal_hepatobiliary_system2.35901817
21MP0001730_embryonic_growth_arrest2.25271250
22MP0000350_abnormal_cell_proliferation2.20105654
23MP0002876_abnormal_thyroid_physiology2.19057985
24MP0010352_gastrointestinal_tract_polyps2.14805246
25MP0009046_muscle_twitch2.10657077
26MP0003890_abnormal_embryonic-extraembry2.08575819
27MP0003045_fibrosis1.98304156
28MP0000383_abnormal_hair_follicle1.92490450
29MP0000569_abnormal_digit_pigmentation1.91272195
30MP0003763_abnormal_thymus_physiology1.89959241
31MP0001501_abnormal_sleep_pattern1.88313221
32MP0010307_abnormal_tumor_latency1.87668072
33MP0001672_abnormal_embryogenesis/_devel1.79415498
34MP0005380_embryogenesis_phenotype1.79415498
35MP0002168_other_aberrant_phenotype1.78818611
36MP0006292_abnormal_olfactory_placode1.75656549
37MP0005085_abnormal_gallbladder_physiolo1.73628276
38MP0004808_abnormal_hematopoietic_stem1.72022639
39MP0005670_abnormal_white_adipose1.70368186
40MP0008875_abnormal_xenobiotic_pharmacok1.70078385
41MP0003656_abnormal_erythrocyte_physiolo1.69857143
42MP0001697_abnormal_embryo_size1.68632265
43MP0008932_abnormal_embryonic_tissue1.68528663
44MP0002084_abnormal_developmental_patter1.66414628
45MP0004197_abnormal_fetal_growth/weight/1.65792645
46MP0003984_embryonic_growth_retardation1.64984505
47MP0003950_abnormal_plasma_membrane1.64875015
48MP0003786_premature_aging1.64552493
49MP0008961_abnormal_basal_metabolism1.64029772
50MP0002088_abnormal_embryonic_growth/wei1.62438878
51MP0001293_anophthalmia1.62124744
52MP0000427_abnormal_hair_cycle1.61531952
53MP0002080_prenatal_lethality1.60977593
54MP0010030_abnormal_orbit_morphology1.60551889
55MP0005645_abnormal_hypothalamus_physiol1.54863362
56MP0003172_abnormal_lysosome_physiology1.52865148
57MP0002086_abnormal_extraembryonic_tissu1.52105691
58MP0004264_abnormal_extraembryonic_tissu1.51987276
59MP0005253_abnormal_eye_physiology1.49451830
60MP0002085_abnormal_embryonic_tissue1.49188096
61MP0009672_abnormal_birth_weight1.46708784
62MP0004215_abnormal_myocardial_fiber1.46684245
63MP0004145_abnormal_muscle_electrophysio1.42483835
64MP0004130_abnormal_muscle_cell1.42044949
65MP0000703_abnormal_thymus_morphology1.41581605
66MP0002019_abnormal_tumor_incidence1.40521799
67MP0005076_abnormal_cell_differentiation1.36875100
68MP0005365_abnormal_bile_salt1.34888663
69MP0005167_abnormal_blood-brain_barrier1.34816264
70MP0000490_abnormal_crypts_of1.34576322
71MP0003119_abnormal_digestive_system1.34091881
72MP0000313_abnormal_cell_death1.30766345
73MP0001984_abnormal_olfaction1.30581527
74MP0001968_abnormal_touch/_nociception1.30051720
75MP0005332_abnormal_amino_acid1.29227433
76MP0002928_abnormal_bile_duct1.26705235
77MP0009745_abnormal_behavioral_response1.26498091
78MP0008872_abnormal_physiological_respon1.26344709
79MP0005395_other_phenotype1.26262231
80MP0005174_abnormal_tail_pigmentation1.23458949
81MP0003252_abnormal_bile_duct1.21448163
82MP0002837_dystrophic_cardiac_calcinosis1.20493335
83MP0004084_abnormal_cardiac_muscle1.19539313
84MP0009703_decreased_birth_body1.18839365
85MP0004484_altered_response_of1.17234559
86MP0002398_abnormal_bone_marrow1.14084278
87MP0005220_abnormal_exocrine_pancreas1.13899606
88MP0002877_abnormal_melanocyte_morpholog1.12678292
89MP0001764_abnormal_homeostasis1.11705434
90MP0003943_abnormal_hepatobiliary_system1.11113758
91MP0010678_abnormal_skin_adnexa1.10932858
92MP0010386_abnormal_urinary_bladder1.09859410
93MP0004924_abnormal_behavior1.09711242
94MP0005386_behavior/neurological_phenoty1.09711242
95MP0005266_abnormal_metabolism1.08818974
96MP0003698_abnormal_male_reproductive1.08211525
97MP0002653_abnormal_ependyma_morphology1.08170496
98MP0002095_abnormal_skin_pigmentation1.07037694
99MP0002722_abnormal_immune_system1.05939027
100MP0010329_abnormal_lipoprotein_level1.05699588
101MP0003567_abnormal_fetal_cardiomyocyte1.03064413
102MP0002089_abnormal_postnatal_growth/wei1.02752634
103MP0005646_abnormal_pituitary_gland1.02569102
104MP0000015_abnormal_ear_pigmentation1.02368545
105MP0006276_abnormal_autonomic_nervous1.01542565
106MP0003718_maternal_effect1.01288973
107MP0002693_abnormal_pancreas_physiology1.00088433
108MP0002075_abnormal_coat/hair_pigmentati0.98797144
109MP0000371_diluted_coat_color0.98520000
110MP0002229_neurodegeneration0.98478243
111MP0000689_abnormal_spleen_morphology0.98467977
112MP0004036_abnormal_muscle_relaxation0.98302551
113MP0005410_abnormal_fertilization0.97876261
114MP0009764_decreased_sensitivity_to0.96640546
115MP0002557_abnormal_social/conspecific_i0.96298885
116MP0003122_maternal_imprinting0.94327467
117MP0009115_abnormal_fat_cell0.93455996
118MP0005384_cellular_phenotype0.92590175
119MP0008775_abnormal_heart_ventricle0.91780114
120MP0005083_abnormal_biliary_tract0.90333679
121MP0001800_abnormal_humoral_immune0.90300142
122MP0005075_abnormal_melanosome_morpholog0.89087958
123MP0003183_abnormal_peptide_metabolism0.88973868
124MP0002638_abnormal_pupillary_reflex0.87558783
125MP0002009_preneoplasia0.87545293
126MP0000230_abnormal_systemic_arterial0.87426820
127MP0001324_abnormal_eye_pigmentation0.86573094
128MP0003705_abnormal_hypodermis_morpholog0.85686930
129MP0002210_abnormal_sex_determination0.85563183
130MP0001485_abnormal_pinna_reflex0.83889825
131MP0002064_seizures0.83785414
132MP0009697_abnormal_copulation0.83387882
133MP0002572_abnormal_emotion/affect_behav0.81730782
134MP0005621_abnormal_cell_physiology0.81698452
135MP0000537_abnormal_urethra_morphology0.80464108
136MP0009643_abnormal_urine_homeostasis0.80227548
137MP0001970_abnormal_pain_threshold0.78945042
138MP0002272_abnormal_nervous_system0.78875926
139MP0000428_abnormal_craniofacial_morphol0.78069915
140MP0002160_abnormal_reproductive_system0.77954756
141MP0001873_stomach_inflammation0.76981001
142MP0004142_abnormal_muscle_tone0.76606082
143MP0002111_abnormal_tail_morphology0.75963380
144MP0002429_abnormal_blood_cell0.75081895
145MP0005448_abnormal_energy_balance0.74838811
146MP0001145_abnormal_male_reproductive0.74031469
147MP0003115_abnormal_respiratory_system0.73948349
148MP0002166_altered_tumor_susceptibility0.73483393
149MP0004742_abnormal_vestibular_system0.73382200
150MP0003879_abnormal_hair_cell0.73349162
151MP0001186_pigmentation_phenotype0.73012223
152MP0001502_abnormal_circadian_rhythm0.72645753
153MP0001915_intracranial_hemorrhage0.72272041
154MP0000631_abnormal_neuroendocrine_gland0.71467620
155MP0002078_abnormal_glucose_homeostasis0.71057608
156MP0006054_spinal_hemorrhage0.70770523
157MP0001286_abnormal_eye_development0.70731294
158MP0003935_abnormal_craniofacial_develop0.70658304
159MP0002067_abnormal_sensory_capabilities0.70484777
160MP0001756_abnormal_urination0.70187973
161MP0001765_abnormal_ion_homeostasis0.70069857
162MP0000470_abnormal_stomach_morphology0.69518443
163MP0003632_abnormal_nervous_system0.68895476
164MP0002092_abnormal_eye_morphology0.68378446
165MP0005389_reproductive_system_phenotype0.66592010
166MP0005671_abnormal_response_to0.66257964
167MP0001919_abnormal_reproductive_system0.65774304
168MP0000716_abnormal_immune_system0.65085593
169MP0002736_abnormal_nociception_after0.64685140
170MP0000358_abnormal_cell_content/0.63890496
171MP0003861_abnormal_nervous_system0.62994827
172MP0004133_heterotaxia0.61688397
173MP0000477_abnormal_intestine_morphology0.61558366
174MP0000653_abnormal_sex_gland0.61336561
175MP0002925_abnormal_cardiovascular_devel0.60177763
176MP0001119_abnormal_female_reproductive0.60171020
177MP0001929_abnormal_gametogenesis0.58178913
178MP0002114_abnormal_axial_skeleton0.56961431
179MP0003221_abnormal_cardiomyocyte_apopto0.56531056
180MP0004233_abnormal_muscle_weight0.55056425
181MP0006072_abnormal_retinal_apoptosis0.54573495
182MP0001986_abnormal_taste_sensitivity0.54564023
183MP0000678_abnormal_parathyroid_gland0.53704106

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.49412430
2Gaze-evoked nystagmus (HP:0000640)4.07538888
3Attenuation of retinal blood vessels (HP:0007843)3.92947083
4Molar tooth sign on MRI (HP:0002419)3.89756320
5Abnormality of midbrain morphology (HP:0002418)3.89756320
6Birth length less than 3rd percentile (HP:0003561)3.89617250
7Hyperventilation (HP:0002883)3.77203611
8Ependymoma (HP:0002888)3.76185434
9Pancreatic fibrosis (HP:0100732)3.74157358
10Medulloblastoma (HP:0002885)3.74142354
11Colon cancer (HP:0003003)3.72150525
12Volvulus (HP:0002580)3.70171422
13Abnormality of the renal cortex (HP:0011035)3.61037377
14Nephronophthisis (HP:0000090)3.48047796
15True hermaphroditism (HP:0010459)3.45161241
16Genetic anticipation (HP:0003743)3.43298781
17Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.29727527
18Cerebellar dysplasia (HP:0007033)3.25513281
19Chromsome breakage (HP:0040012)3.23385496
20Type II lissencephaly (HP:0007260)3.18501172
21Decreased circulating renin level (HP:0003351)3.15811620
22Abnormality of the renal medulla (HP:0100957)3.15182099
23Tubular atrophy (HP:0000092)3.10886094
24Fair hair (HP:0002286)3.08677143
25Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.06636383
26Abnormality of alanine metabolism (HP:0010916)3.06636383
27Hyperalaninemia (HP:0003348)3.06636383
28Tubulointerstitial nephritis (HP:0001970)3.03871688
29Absent/shortened dynein arms (HP:0200106)3.02687215
30Dynein arm defect of respiratory motile cilia (HP:0012255)3.02687215
31Selective tooth agenesis (HP:0001592)2.98432856
32Aplasia/Hypoplasia of the tibia (HP:0005772)2.93016149
33Clumsiness (HP:0002312)2.91283028
34Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.90073941
35Central scotoma (HP:0000603)2.89432378
36Abnormality of the labia minora (HP:0012880)2.89136795
37Medial flaring of the eyebrow (HP:0010747)2.87442877
38Dysmetric saccades (HP:0000641)2.86366147
39Hyperkalemia (HP:0002153)2.86107369
40Aplastic anemia (HP:0001915)2.86011090
41Chromosomal breakage induced by crosslinking agents (HP:0003221)2.82889913
42Bony spicule pigmentary retinopathy (HP:0007737)2.82348629
43Protruding tongue (HP:0010808)2.81591480
44Thrombocytosis (HP:0001894)2.80865301
45Astrocytoma (HP:0009592)2.75600261
46Abnormality of the astrocytes (HP:0100707)2.75600261
47Degeneration of anterior horn cells (HP:0002398)2.74868593
48Abnormality of the anterior horn cell (HP:0006802)2.74868593
49Increased nuchal translucency (HP:0010880)2.74547278
50Cystic liver disease (HP:0006706)2.74066317
51Congenital stationary night blindness (HP:0007642)2.72597852
52Rhabdomyosarcoma (HP:0002859)2.71657253
53Glioma (HP:0009733)2.68629633
54Abnormality of the fingertips (HP:0001211)2.68028036
55Progressive cerebellar ataxia (HP:0002073)2.59940520
56Myelodysplasia (HP:0002863)2.59244446
57Amaurosis fugax (HP:0100576)2.57085819
58Abnormality of chromosome stability (HP:0003220)2.52725180
5911 pairs of ribs (HP:0000878)2.52563718
60Agnosia (HP:0010524)2.52445098
61Abnormal respiratory motile cilium physiology (HP:0012261)2.52317242
62Basal cell carcinoma (HP:0002671)2.49323109
63Congenital sensorineural hearing impairment (HP:0008527)2.48161568
64Increased neuronal autofluorescent lipopigment (HP:0002074)2.47489500
65Renal cortical cysts (HP:0000803)2.46230793
66Abnormal number of incisors (HP:0011064)2.46107392
67Optic nerve coloboma (HP:0000588)2.44730615
68Thyroid-stimulating hormone excess (HP:0002925)2.43937787
69Poor coordination (HP:0002370)2.43726177
70Absent speech (HP:0001344)2.42941660
71Freckling (HP:0001480)2.42917930
72Chronic bronchitis (HP:0004469)2.41365847
73Abnormal ciliary motility (HP:0012262)2.40533137
74Prominent metopic ridge (HP:0005487)2.38848597
75Deviation of the thumb (HP:0009603)2.37585222
76Proximal placement of thumb (HP:0009623)2.36471633
77Abnormality of the metopic suture (HP:0005556)2.36137020
78Urethral obstruction (HP:0000796)2.35679366
79Short 4th metacarpal (HP:0010044)2.34671422
80Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.34671422
81Congenital hepatic fibrosis (HP:0002612)2.33515545
82Generalized hypopigmentation of hair (HP:0011358)2.33348407
83Oral leukoplakia (HP:0002745)2.32205266
84Inability to walk (HP:0002540)2.30767773
85Progressive inability to walk (HP:0002505)2.28528861
86Abnormal drinking behavior (HP:0030082)2.28133874
87Polydipsia (HP:0001959)2.28133874
88Abnormality of the preputium (HP:0100587)2.27149565
89Missing ribs (HP:0000921)2.26304570
90Broad-based gait (HP:0002136)2.25977299
91Rhinitis (HP:0012384)2.22890525
92Abnormal respiratory epithelium morphology (HP:0012253)2.22844433
93Abnormal respiratory motile cilium morphology (HP:0005938)2.22844433
94Widely spaced teeth (HP:0000687)2.21141447
95Bronchiectasis (HP:0002110)2.21099079
96Furrowed tongue (HP:0000221)2.21003230
97Gait imbalance (HP:0002141)2.19688460
98Patellar aplasia (HP:0006443)2.19494208
99Long eyelashes (HP:0000527)2.19025639
100Congenital primary aphakia (HP:0007707)2.18386448
101Aplasia/Hypoplasia of the uvula (HP:0010293)2.18161586
102Aplasia/Hypoplasia of the sternum (HP:0006714)2.17265284
103Neoplasm of striated muscle (HP:0009728)2.16975052
104Hypoplastic labia majora (HP:0000059)2.16625406
105Abnormal rod and cone electroretinograms (HP:0008323)2.16150971
106Meckel diverticulum (HP:0002245)2.15310290
107Trigonocephaly (HP:0000243)2.13937965
108T lymphocytopenia (HP:0005403)2.13574733
109Truncal obesity (HP:0001956)2.13138441
110Abnormality of the ileum (HP:0001549)2.12867619
111Abnormality of the carotid arteries (HP:0005344)2.09447893
112Scotoma (HP:0000575)2.08514156
113Neoplasm of the oral cavity (HP:0100649)2.08075920
114Lymphoma (HP:0002665)2.06272487
115Decreased central vision (HP:0007663)2.04983693
116Poikiloderma (HP:0001029)2.04815539
117Clubbing of toes (HP:0100760)2.04189635
118Broad palm (HP:0001169)2.03848931
119Abnormality of the labia majora (HP:0012881)2.03133789
120Hypoplasia of the thymus (HP:0000778)2.00675116
121Cafe-au-lait spot (HP:0000957)2.00012903
122B lymphocytopenia (HP:0010976)1.99483906
123Abnormality of B cell number (HP:0010975)1.99483906
124Abnormality of DNA repair (HP:0003254)1.98614926
125Aplasia/Hypoplasia of the patella (HP:0006498)1.98020524
126Highly arched eyebrow (HP:0002553)1.98010179
127Bone marrow hypocellularity (HP:0005528)1.95558319
128Retinitis pigmentosa (HP:0000510)1.95482378
129Abnormality of the columella (HP:0009929)1.95106708
130Microvesicular hepatic steatosis (HP:0001414)1.94157334
131Nephrogenic diabetes insipidus (HP:0009806)1.93376819
132Dialeptic seizures (HP:0011146)1.93272741
133Renovascular hypertension (HP:0100817)1.93226340
134Prominent nose (HP:0000448)1.92691822
135Abnormality of the lower motor neuron (HP:0002366)1.92640997
136Sloping forehead (HP:0000340)1.92604780
137Abnormality of macular pigmentation (HP:0008002)1.92384009
138Supernumerary spleens (HP:0009799)1.92079240
139Large for gestational age (HP:0001520)1.92052834
140Abnormal biliary tract physiology (HP:0012439)1.91833429
141Bile duct proliferation (HP:0001408)1.91833429
142Small intestinal stenosis (HP:0012848)1.90990026
143Duodenal stenosis (HP:0100867)1.90990026
144Premature graying of hair (HP:0002216)1.90878658
145Aplasia/Hypoplasia of the tongue (HP:0010295)1.90365529
146Deep philtrum (HP:0002002)1.90043544
147Lissencephaly (HP:0001339)1.88576988
148Cutis marmorata (HP:0000965)1.87875495
149Partial agenesis of the corpus callosum (HP:0001338)1.86236774
150Skin tags (HP:0010609)1.85442479
151Intestinal atresia (HP:0011100)1.84863300
152Ectopic kidney (HP:0000086)1.84373021
153Tubulointerstitial abnormality (HP:0001969)1.84088345
154Renal duplication (HP:0000075)1.84044550
155Obsessive-compulsive behavior (HP:0000722)1.83795551
156Chronic hepatic failure (HP:0100626)1.82998356
157Abnormality of the pons (HP:0007361)1.82790728
158Hyperacusis (HP:0010780)1.82195937
159Breast hypoplasia (HP:0003187)1.82098341
160Hypoplasia of the pons (HP:0012110)1.81993357
161High pitched voice (HP:0001620)1.81713875
162Enlarged kidneys (HP:0000105)1.81588639
163Blepharitis (HP:0000498)1.80858114
164Neoplasm of the pancreas (HP:0002894)1.79437600
165Preauricular skin tag (HP:0000384)1.79102041
166Prominent nasal bridge (HP:0000426)1.78645201
167Increased cerebral lipofuscin (HP:0011813)1.78515087
168Biliary tract neoplasm (HP:0100574)1.78389021
169Limb hypertonia (HP:0002509)1.77744179
170Prostate neoplasm (HP:0100787)1.77525523
171Postaxial foot polydactyly (HP:0001830)1.75615567
172Ketoacidosis (HP:0001993)1.75584997
173Nephroblastoma (Wilms tumor) (HP:0002667)1.75427599
174Astigmatism (HP:0000483)1.75243029
175Anal stenosis (HP:0002025)1.75238115
176Neoplasm of the colon (HP:0100273)1.74623051
177Abnormality of the nasal septum (HP:0000419)1.74533997
178Ketosis (HP:0001946)1.74318362
179Cellular immunodeficiency (HP:0005374)1.74236628
180Abnormality of T cell number (HP:0011839)1.74206846
181IgM deficiency (HP:0002850)1.73970387
182Abnormality of the duodenum (HP:0002246)1.73770269
183Spastic paraplegia (HP:0001258)1.73681863
184Pelvic girdle muscle weakness (HP:0003749)1.73497836
185Delayed puberty (HP:0000823)1.70006479
186Gastrointestinal carcinoma (HP:0002672)1.67965637
187Malignant gastrointestinal tract tumors (HP:0006749)1.67965637
188Embryonal renal neoplasm (HP:0011794)1.66135729
189Abnormal lung lobation (HP:0002101)1.65212304
190Abnormal biliary tract morphology (HP:0012440)1.64713181

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK8.66595360
2MKNK23.81766719
3CDC73.81428535
4PASK3.63936477
5TSSK63.46676654
6WEE13.34130406
7MKNK13.13531945
8BMPR1B2.78966362
9BRD42.69361969
10EEF2K2.48864767
11FLT32.31560591
12BLK2.27617203
13SRPK12.22021723
14NEK12.12354883
15ADRBK22.11188958
16EIF2AK12.09277617
17MAP4K22.06910296
18NEK22.04913236
19BRSK22.03241303
20BUB12.02062431
21ATR2.01984137
22CAMKK21.93106237
23CAMK1D1.90845485
24AKT31.85934087
25INSRR1.82038301
26SCYL21.81215800
27CCNB11.75914350
28TGFBR11.75522539
29RPS6KB21.71810165
30CAMK1G1.67840512
31CDK121.65061291
32PKN21.60482320
33MAP3K91.59314440
34MAPK131.58501254
35MAPKAPK31.57428292
36TTK1.54351116
37PLK31.52085460
38STK38L1.50890986
39ACVR1B1.49540289
40EIF2AK31.49358559
41PIK3CG1.48347242
42PLK11.43893766
43IRAK11.40529093
44BRSK11.36744178
45MAP4K11.35705556
46WNK31.34228053
47TNIK1.33310546
48TRPM71.32895986
49CHEK11.29992694
50SIK21.26964260
51MAP3K71.25100099
52CDK71.22679952
53VRK11.22255645
54EPHA21.21850487
55MAPKAPK51.19353386
56PRPF4B1.16516809
57GRK11.15761802
58PLK41.14070575
59MAP3K131.14004780
60ALK1.13155945
61AURKB1.12591482
62TNK21.10781221
63ATM1.09236470
64PRKAA21.08799114
65PRKAA11.06722410
66SGK21.06163307
67CDK41.03481829
68CHEK20.99278635
69EPHA30.99199114
70ZAK0.98878973
71CDK20.97680588
72WNK40.97007223
73JAK30.95789854
74DAPK10.92488201
75EPHA40.91614792
76OBSCN0.89339930
77MAPK110.88912436
78TAOK20.88290064
79OXSR10.87598433
80FGFR10.86855408
81PAK30.86852099
82FER0.84944096
83NLK0.84638870
84RPS6KB10.82901648
85SIK30.82335268
86MAP2K30.79710938
87CDC42BPA0.79699964
88STK390.78908598
89ZAP700.77765915
90CHUK0.77689449
91SGK30.77527054
92PRKCE0.75774089
93BTK0.75559471
94CDK10.74619583
95STK30.74570021
96IKBKB0.73355794
97RPS6KA40.73326417
98TXK0.69880138
99PINK10.69405141
100ITK0.68716088
101ADRBK10.66576692
102LATS10.63540690
103STK380.62916008
104PRKDC0.62112813
105PIK3CA0.61326542
106CSNK2A20.60400640
107MAP3K80.60295411
108MARK30.59289892
109PDK10.57557203
110PTK2B0.57431516
111MAPK150.56842518
112KIT0.56100382
113MAP2K60.54993466
114DAPK20.54382135
115MAPK140.54166706
116TLK10.53495191
117PRKCQ0.53269465
118CDK60.50923426
119STK100.50739277
120SGK10.50144324
121CSNK1E0.49244575
122MAP3K40.48795195
123CDK90.48674821
124CAMK10.46833988
125PAK40.46465607
126MTOR0.45901342
127CSF1R0.45682727
128PNCK0.44784315
129WNK10.43919797
130MELK0.42649210
131YES10.42510820
132GSK3B0.41283234
133NTRK30.41189819
134BCR0.38112070
135CDK80.37973373
136PKN10.37888784
137PDK20.37524071
138AURKA0.36727659
139TEC0.36723500
140FGFR30.36453517
141PRKCI0.36424736
142AKT10.35901409
143MAPK80.35766970
144CSNK1D0.35251037
145CLK10.34447727
146CSNK2A10.32890672
147STK40.32316834
148STK160.32174444
149PLK20.31763039
150NME10.31704553
151CASK0.31703968
152NUAK10.31596731
153TAOK30.30807399
154SGK2230.30649301
155SGK4940.30649301
156RIPK10.30455827
157CAMKK10.30365476
158ERBB30.29878270
159CAMK40.29377634
160MAPK10.29161845
161HIPK20.29104070
162SYK0.28844965
163PIM10.28161663
164KSR10.27923321
165CDK30.27593390
166STK110.27283138

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.82591707
2Mismatch repair_Homo sapiens_hsa034304.62052647
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.62745704
4One carbon pool by folate_Homo sapiens_hsa006703.58738271
5Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.55464745
6Spliceosome_Homo sapiens_hsa030403.28969609
7RNA transport_Homo sapiens_hsa030133.22600271
8Butanoate metabolism_Homo sapiens_hsa006503.13781428
9Homologous recombination_Homo sapiens_hsa034403.05655386
10Base excision repair_Homo sapiens_hsa034103.01104211
11Nucleotide excision repair_Homo sapiens_hsa034202.73019033
12Non-homologous end-joining_Homo sapiens_hsa034502.56751423
13Linoleic acid metabolism_Homo sapiens_hsa005912.50083928
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.49079485
15Tryptophan metabolism_Homo sapiens_hsa003802.46000814
16Cell cycle_Homo sapiens_hsa041102.43899036
17Primary bile acid biosynthesis_Homo sapiens_hsa001202.36627863
18Fanconi anemia pathway_Homo sapiens_hsa034602.36182094
19ABC transporters_Homo sapiens_hsa020102.20442970
20mRNA surveillance pathway_Homo sapiens_hsa030152.13557154
21alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.06880983
22Propanoate metabolism_Homo sapiens_hsa006402.06719907
23Regulation of autophagy_Homo sapiens_hsa041401.96460880
24RNA polymerase_Homo sapiens_hsa030201.88696308
25Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87854131
26RNA degradation_Homo sapiens_hsa030181.81391719
27Phototransduction_Homo sapiens_hsa047441.75504117
28Steroid hormone biosynthesis_Homo sapiens_hsa001401.74915995
29Pyrimidine metabolism_Homo sapiens_hsa002401.67390291
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.61644019
31Primary immunodeficiency_Homo sapiens_hsa053401.59390912
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.56160618
33Nitrogen metabolism_Homo sapiens_hsa009101.54002323
34Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.53938191
35Caffeine metabolism_Homo sapiens_hsa002321.49290963
36Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.47496135
37Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.46114426
38Intestinal immune network for IgA production_Homo sapiens_hsa046721.40059118
39Ether lipid metabolism_Homo sapiens_hsa005651.37520855
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.36991101
41Taste transduction_Homo sapiens_hsa047421.34700084
42Biosynthesis of amino acids_Homo sapiens_hsa012301.26451388
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.24109200
44Chemical carcinogenesis_Homo sapiens_hsa052041.23482205
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21688256
46p53 signaling pathway_Homo sapiens_hsa041151.19212010
47Basal transcription factors_Homo sapiens_hsa030221.19031250
48Lysine degradation_Homo sapiens_hsa003101.16508106
49Nicotine addiction_Homo sapiens_hsa050331.14551724
50Purine metabolism_Homo sapiens_hsa002301.11282076
51Systemic lupus erythematosus_Homo sapiens_hsa053221.09247975
52Ovarian steroidogenesis_Homo sapiens_hsa049131.08073921
53beta-Alanine metabolism_Homo sapiens_hsa004101.07332310
54Retinol metabolism_Homo sapiens_hsa008301.05400872
55Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.05369666
56Herpes simplex infection_Homo sapiens_hsa051681.05221682
57Viral carcinogenesis_Homo sapiens_hsa052031.04019613
58Selenocompound metabolism_Homo sapiens_hsa004501.04016332
59Histidine metabolism_Homo sapiens_hsa003401.02704290
60Dorso-ventral axis formation_Homo sapiens_hsa043201.00689244
61Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99957984
62Epstein-Barr virus infection_Homo sapiens_hsa051690.99358175
63Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.97226465
64Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.96879953
65Ribosome_Homo sapiens_hsa030100.93875790
66Antigen processing and presentation_Homo sapiens_hsa046120.92891991
67HTLV-I infection_Homo sapiens_hsa051660.91122910
68Glycerolipid metabolism_Homo sapiens_hsa005610.88344949
69Fatty acid degradation_Homo sapiens_hsa000710.88032261
70Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.87910086
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86749224
722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86506037
73Oocyte meiosis_Homo sapiens_hsa041140.86447479
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.86202503
75Arachidonic acid metabolism_Homo sapiens_hsa005900.85126813
76Morphine addiction_Homo sapiens_hsa050320.84282585
77mTOR signaling pathway_Homo sapiens_hsa041500.84265995
78Sphingolipid metabolism_Homo sapiens_hsa006000.84039585
79Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84028829
80Cyanoamino acid metabolism_Homo sapiens_hsa004600.83976378
81Serotonergic synapse_Homo sapiens_hsa047260.83770634
82Long-term depression_Homo sapiens_hsa047300.82527590
83Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.79704166
84Calcium signaling pathway_Homo sapiens_hsa040200.79113584
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.74700206
86Glutamatergic synapse_Homo sapiens_hsa047240.70997487
87N-Glycan biosynthesis_Homo sapiens_hsa005100.70441235
88Colorectal cancer_Homo sapiens_hsa052100.69323542
89Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68436117
90Alcoholism_Homo sapiens_hsa050340.68072197
91Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.67501097
92Fatty acid biosynthesis_Homo sapiens_hsa000610.67452839
93Insulin secretion_Homo sapiens_hsa049110.66248305
94Vascular smooth muscle contraction_Homo sapiens_hsa042700.63502243
95Aldosterone synthesis and secretion_Homo sapiens_hsa049250.63078788
96Glycerophospholipid metabolism_Homo sapiens_hsa005640.62540390
97Fructose and mannose metabolism_Homo sapiens_hsa000510.62499966
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62049489
99Asthma_Homo sapiens_hsa053100.61869222
100Measles_Homo sapiens_hsa051620.60340986
101Olfactory transduction_Homo sapiens_hsa047400.59700437
102Peroxisome_Homo sapiens_hsa041460.59650957
103Thyroid cancer_Homo sapiens_hsa052160.59230370
104Salivary secretion_Homo sapiens_hsa049700.58075873
105Proteasome_Homo sapiens_hsa030500.57012626
106Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56657723
107MicroRNAs in cancer_Homo sapiens_hsa052060.55501042
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.55347576
109T cell receptor signaling pathway_Homo sapiens_hsa046600.54663823
110Oxytocin signaling pathway_Homo sapiens_hsa049210.53791973
111Drug metabolism - other enzymes_Homo sapiens_hsa009830.53455480
112Pentose phosphate pathway_Homo sapiens_hsa000300.52986250
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.52144311
114Circadian entrainment_Homo sapiens_hsa047130.51126880
115Carbon metabolism_Homo sapiens_hsa012000.50858303
116Graft-versus-host disease_Homo sapiens_hsa053320.49504785
117Non-small cell lung cancer_Homo sapiens_hsa052230.48127955
118Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47893648
119Fatty acid metabolism_Homo sapiens_hsa012120.46206078
120GABAergic synapse_Homo sapiens_hsa047270.45993481
121Hepatitis B_Homo sapiens_hsa051610.44606422
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44472613
123Small cell lung cancer_Homo sapiens_hsa052220.44236230
124Type I diabetes mellitus_Homo sapiens_hsa049400.44001078
125Endometrial cancer_Homo sapiens_hsa052130.43816738
126Notch signaling pathway_Homo sapiens_hsa043300.43813889
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43528782
128Galactose metabolism_Homo sapiens_hsa000520.43303464
129Cholinergic synapse_Homo sapiens_hsa047250.41883215
130Chronic myeloid leukemia_Homo sapiens_hsa052200.41626076
131Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.41581922
132Sulfur metabolism_Homo sapiens_hsa009200.40994324
133Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.40969630
134HIF-1 signaling pathway_Homo sapiens_hsa040660.40233770
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39212319
136Allograft rejection_Homo sapiens_hsa053300.38219863
137Thyroid hormone synthesis_Homo sapiens_hsa049180.37279862
138PPAR signaling pathway_Homo sapiens_hsa033200.36592800
139Choline metabolism in cancer_Homo sapiens_hsa052310.36102575
140Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.35590298
141cGMP-PKG signaling pathway_Homo sapiens_hsa040220.35516646
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35430843
143Glucagon signaling pathway_Homo sapiens_hsa049220.34457200
144Adherens junction_Homo sapiens_hsa045200.34085954
145Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32469597
146Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32347317
147Neurotrophin signaling pathway_Homo sapiens_hsa047220.31448349
148Acute myeloid leukemia_Homo sapiens_hsa052210.30698681
149Influenza A_Homo sapiens_hsa051640.30015005
150Basal cell carcinoma_Homo sapiens_hsa052170.29492784
151Insulin signaling pathway_Homo sapiens_hsa049100.26867597
152FoxO signaling pathway_Homo sapiens_hsa040680.26384745
153Long-term potentiation_Homo sapiens_hsa047200.25826635
154Hippo signaling pathway_Homo sapiens_hsa043900.25749818
155Legionellosis_Homo sapiens_hsa051340.25727913
156Maturity onset diabetes of the young_Homo sapiens_hsa049500.25036769
157Circadian rhythm_Homo sapiens_hsa047100.24404696
158Inositol phosphate metabolism_Homo sapiens_hsa005620.24326152
159Wnt signaling pathway_Homo sapiens_hsa043100.23775373
160Prostate cancer_Homo sapiens_hsa052150.23503257
161Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.23379661
162Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22998857
163NF-kappa B signaling pathway_Homo sapiens_hsa040640.22465176
164Pancreatic cancer_Homo sapiens_hsa052120.21990474
165TGF-beta signaling pathway_Homo sapiens_hsa043500.21442096
166Type II diabetes mellitus_Homo sapiens_hsa049300.21188756
167Pathways in cancer_Homo sapiens_hsa052000.20425112
168Longevity regulating pathway - mammal_Homo sapiens_hsa042110.18361763
169Insulin resistance_Homo sapiens_hsa049310.16668015
170Protein export_Homo sapiens_hsa030600.15144036
171Melanoma_Homo sapiens_hsa052180.14853433
172Jak-STAT signaling pathway_Homo sapiens_hsa046300.14500978

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