NFXL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)4.79147693
2modulation by symbiont of host defense response (GO:0052031)4.79147693
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.79147693
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.79147693
5positive regulation by organism of defense response of other organism involved in symbiotic interact4.79147693
6modulation by symbiont of host immune response (GO:0052553)4.79147693
7protein localization to kinetochore (GO:0034501)4.60441396
8microglial cell activation (GO:0001774)4.51641486
9mitotic metaphase plate congression (GO:0007080)4.37794647
10chromatin remodeling at centromere (GO:0031055)4.27187264
11CENP-A containing nucleosome assembly (GO:0034080)4.25035673
12synapsis (GO:0007129)4.20416961
13protein localization to chromosome, centromeric region (GO:0071459)4.18851519
14regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.18260756
15regulation of mitotic spindle checkpoint (GO:1903504)4.18260756
16DNA strand elongation involved in DNA replication (GO:0006271)4.16584771
17DNA strand elongation (GO:0022616)4.02117546
18regulation of centriole replication (GO:0046599)3.97340793
19DNA replication checkpoint (GO:0000076)3.96418346
20metaphase plate congression (GO:0051310)3.96411955
21attachment of spindle microtubules to kinetochore (GO:0008608)3.93275209
22neutrophil activation involved in immune response (GO:0002283)3.93083510
23double-strand break repair via nonhomologous end joining (GO:0006303)3.84766066
24non-recombinational repair (GO:0000726)3.84766066
25negative regulation of mitotic sister chromatid separation (GO:2000816)3.81640861
26negative regulation of sister chromatid segregation (GO:0033046)3.81640861
27negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.81640861
28negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.81640861
29negative regulation of mitotic sister chromatid segregation (GO:0033048)3.81640861
30mitotic nuclear envelope disassembly (GO:0007077)3.76526676
31somatic diversification of immune receptors via somatic mutation (GO:0002566)3.75214817
32somatic hypermutation of immunoglobulin genes (GO:0016446)3.75214817
33negative regulation of chromosome segregation (GO:0051985)3.73213340
34spindle checkpoint (GO:0031577)3.73127670
35mitotic spindle checkpoint (GO:0071174)3.70576303
36establishment of integrated proviral latency (GO:0075713)3.67444032
37regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.66292385
38regulation of mitotic metaphase/anaphase transition (GO:0030071)3.66292385
39DNA unwinding involved in DNA replication (GO:0006268)3.66035080
40histone exchange (GO:0043486)3.64405691
41establishment of chromosome localization (GO:0051303)3.62067366
42IMP biosynthetic process (GO:0006188)3.61737677
43mitotic chromosome condensation (GO:0007076)3.61359023
44telomere maintenance via semi-conservative replication (GO:0032201)3.60851879
45regulation of mitotic sister chromatid separation (GO:0010965)3.59529717
46regulation of mitotic sister chromatid segregation (GO:0033047)3.59529717
47regulation of sister chromatid segregation (GO:0033045)3.59529717
48mitotic spindle assembly checkpoint (GO:0007094)3.59008175
49membrane disassembly (GO:0030397)3.55792093
50nuclear envelope disassembly (GO:0051081)3.55792093
51sister chromatid cohesion (GO:0007062)3.54555232
52DNA replication-independent nucleosome organization (GO:0034724)3.53464351
53DNA replication-independent nucleosome assembly (GO:0006336)3.53464351
54spindle assembly checkpoint (GO:0071173)3.53007029
55regulation of meiosis I (GO:0060631)3.50951436
56macrophage activation involved in immune response (GO:0002281)3.47432283
57purine nucleobase biosynthetic process (GO:0009113)3.46630607
58DNA double-strand break processing (GO:0000729)3.46505786
59regulation of chromosome segregation (GO:0051983)3.45966642
60eosinophil chemotaxis (GO:0048245)3.43721314
61regulation of histone H3-K9 methylation (GO:0051570)3.41727329
62DNA replication initiation (GO:0006270)3.39471714
63telomere maintenance via recombination (GO:0000722)3.38812450
64protein localization to chromosome (GO:0034502)3.37635500
65telomere maintenance via telomerase (GO:0007004)3.36874980
66resolution of meiotic recombination intermediates (GO:0000712)3.31615483
67detection of molecule of bacterial origin (GO:0032490)3.29392312
68regulation of fever generation (GO:0031620)3.28739682
69mitotic recombination (GO:0006312)3.28597382
70regulation of double-strand break repair via homologous recombination (GO:0010569)3.26887769
71positive regulation of histone H3-K4 methylation (GO:0051571)3.25232966
72RNA-dependent DNA replication (GO:0006278)3.25120190
73IMP metabolic process (GO:0046040)3.23917472
74nucleobase biosynthetic process (GO:0046112)3.23177299
75positive regulation of chromosome segregation (GO:0051984)3.22247747
76histone mRNA metabolic process (GO:0008334)3.22047411
77mitotic sister chromatid segregation (GO:0000070)3.21141582
78negative regulation of DNA recombination (GO:0045910)3.19379451
79DNA methylation involved in gamete generation (GO:0043046)3.18636093
80ribosome assembly (GO:0042255)3.17290414
81regulation of centrosome cycle (GO:0046605)3.15990073
82positive regulation of interferon-alpha production (GO:0032727)3.15731151
83telomere maintenance via telomere lengthening (GO:0010833)3.15292699
84DNA replication-dependent nucleosome assembly (GO:0006335)3.13975330
85DNA replication-dependent nucleosome organization (GO:0034723)3.13975330
86sister chromatid segregation (GO:0000819)3.13515217
87regulation of RIG-I signaling pathway (GO:0039535)3.12126414
88regulation of spindle checkpoint (GO:0090231)3.09751514
89positive regulation of heat generation (GO:0031652)3.09709037
90regulation of mononuclear cell migration (GO:0071675)3.09359212
91response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.07371079
92response to host immune response (GO:0052572)3.07371079
93positive regulation of cellular amide metabolic process (GO:0034250)3.05770906
94replication fork processing (GO:0031297)3.04231935
95regulation of helicase activity (GO:0051095)3.04011544
96histone H2A acetylation (GO:0043968)3.03388436
97gene silencing by RNA (GO:0031047)3.02344688
98regulation of DNA methylation (GO:0044030)3.00907807
99nucleotide-excision repair, DNA gap filling (GO:0006297)3.00121855
100pre-miRNA processing (GO:0031054)2.99241078
101macrophage activation (GO:0042116)2.99133108
102telomere maintenance (GO:0000723)2.97929736
103negative regulation of mitosis (GO:0045839)2.96514602
104positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.96506976
105positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.96506976
106positive regulation of mitotic sister chromatid separation (GO:1901970)2.96506976
107monocyte chemotaxis (GO:0002548)2.96394261
108N-terminal protein amino acid acetylation (GO:0006474)2.95947737
109regulation of interferon-alpha production (GO:0032647)2.95855144
110DNA geometric change (GO:0032392)2.95379451
111telomere organization (GO:0032200)2.94919946
112regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.94637313
113eosinophil migration (GO:0072677)2.92776577
114regulation of interferon-beta biosynthetic process (GO:0045357)2.86408523
115mesenchymal cell differentiation (GO:0048762)2.84003452
116positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.81829427
117response to peptidoglycan (GO:0032494)2.80957352
118T-helper 1 type immune response (GO:0042088)2.76822859
119antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.76500786
120response to host (GO:0075136)2.75155711
121response to host defenses (GO:0052200)2.75155711
122response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.75155711
123positive regulation of interleukin-1 beta secretion (GO:0050718)2.68562494
124regulation of female gonad development (GO:2000194)2.66765020
125positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.66656860
126negative regulation of translation, ncRNA-mediated (GO:0040033)2.64709411
127regulation of translation, ncRNA-mediated (GO:0045974)2.64709411
128negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.64709411
129germinal center formation (GO:0002467)2.64479068
130I-kappaB phosphorylation (GO:0007252)2.63310707
131pore complex assembly (GO:0046931)2.63064302
132negative regulation of mast cell activation (GO:0033004)2.56200247
133neutrophil activation (GO:0042119)2.53877986
134regulation of heat generation (GO:0031650)2.51179809
135granulocyte activation (GO:0036230)2.50412849
136nuclear pore complex assembly (GO:0051292)2.49611870
137histone H3-K4 trimethylation (GO:0080182)2.48140457
138protein K6-linked ubiquitination (GO:0085020)2.45906394
139positive regulation of interferon-beta production (GO:0032728)2.43917363
140kinetochore organization (GO:0051383)2.43790733
141histone H3-K9 methylation (GO:0051567)2.43457882
142regulation of macrophage chemotaxis (GO:0010758)2.42894217
143regulation of interleukin-1 beta secretion (GO:0050706)2.42529927
144positive regulation of interleukin-1 secretion (GO:0050716)2.42107073
145mitotic sister chromatid cohesion (GO:0007064)2.41617921
146positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.41417587
147response to muramyl dipeptide (GO:0032495)2.39389790
148piRNA metabolic process (GO:0034587)2.39249752
149G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.39190705
150positive regulation of response to biotic stimulus (GO:0002833)2.38997335
151positive regulation of toll-like receptor signaling pathway (GO:0034123)2.38659941
152negative regulation of smooth muscle cell differentiation (GO:0051151)2.38592558
153negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.38188807
154nuclear pore organization (GO:0006999)2.38138798
155regulation of dendritic cell antigen processing and presentation (GO:0002604)2.37616199
156ganglion development (GO:0061548)2.33956864
157mesenchymal cell differentiation involved in renal system development (GO:2001012)2.33400225
158mesenchymal cell differentiation involved in kidney development (GO:0072161)2.33400225
159detection of external biotic stimulus (GO:0098581)2.33276342
160kinetochore assembly (GO:0051382)2.33244595
161centriole replication (GO:0007099)2.32230595
162RNA destabilization (GO:0050779)2.29851886
163phagocytosis, engulfment (GO:0006911)2.29376623
164meiotic chromosome segregation (GO:0045132)2.29056976
165production of molecular mediator involved in inflammatory response (GO:0002532)2.27712849
166positive regulation of lymphocyte migration (GO:2000403)2.27604999
167regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.27031061
168positive regulation of SMAD protein import into nucleus (GO:0060391)2.26867940
169pinocytosis (GO:0006907)2.26406239
170immunoglobulin mediated immune response (GO:0016064)2.26023481
171Notch signaling involved in heart development (GO:0061314)2.24378699
172osteoclast differentiation (GO:0030316)2.23355076
173negative regulation of DNA-dependent DNA replication (GO:2000104)2.22675577
174positive regulation of interleukin-1 beta production (GO:0032731)2.21987127
175superoxide anion generation (GO:0042554)2.21384168
176positive regulation of T cell migration (GO:2000406)2.19791636
177positive regulation of leukocyte apoptotic process (GO:2000108)2.18741700
178natural killer cell mediated immunity (GO:0002228)2.18154688
179natural killer cell mediated cytotoxicity (GO:0042267)2.18154688
180regulation of interferon-gamma biosynthetic process (GO:0045072)2.17572516
181energy homeostasis (GO:0097009)2.15851068
182poly(A)+ mRNA export from nucleus (GO:0016973)2.14479605
183negative regulation of stem cell proliferation (GO:2000647)2.14311582
184neutrophil mediated immunity (GO:0002446)2.13532498
185cellular response to gamma radiation (GO:0071480)2.13368637
186epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.11328286
187regulation of DNA endoreduplication (GO:0032875)2.10233292
188detection of biotic stimulus (GO:0009595)2.10193378
189cell proliferation involved in kidney development (GO:0072111)2.10078244

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F4_17652178_ChIP-ChIP_JURKAT_Human4.11947346
2BP1_19119308_ChIP-ChIP_Hs578T_Human3.61607480
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.54534735
4IRF8_21731497_ChIP-ChIP_J774_Mouse3.40303336
5STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse3.27325870
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.05220881
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.00693421
8MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.88398120
9IRF8_22096565_ChIP-ChIP_GC-B_Human2.84608965
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.76924567
11* EST1_17652178_ChIP-ChIP_JURKAT_Human2.76058405
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.65907889
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.65753652
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.64344045
15ELK1_19687146_ChIP-ChIP_HELA_Human2.45258017
16PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.44659674
17SMAD_19615063_ChIP-ChIP_OVARY_Human2.40510466
18POU3F2_20337985_ChIP-ChIP_501MEL_Human2.36192984
19* IRF8_27001747_Chip-Seq_BMDM_Mouse2.34011746
20Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.30218743
21* VDR_23849224_ChIP-Seq_CD4+_Human2.27324462
22AR_21909140_ChIP-Seq_LNCAP_Human2.23120410
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.18314539
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.15987244
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.14137545
26PADI4_21655091_ChIP-ChIP_MCF-7_Human2.11887545
27MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.11632785
28FUS_26573619_Chip-Seq_HEK293_Human2.09235949
29FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.09213917
30* ETS1_20019798_ChIP-Seq_JURKAT_Human2.08518520
31FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.05056101
32YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.04094025
33GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.04042121
34* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.03639985
35E2F1_21310950_ChIP-Seq_MCF-7_Human2.03246811
36JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.01552352
37TP63_19390658_ChIP-ChIP_HaCaT_Human2.00781875
38HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.00766585
39FOXP3_21729870_ChIP-Seq_TREG_Human2.00648213
40IGF1R_20145208_ChIP-Seq_DFB_Human1.99575766
41EWS_26573619_Chip-Seq_HEK293_Human1.92173383
42MYC_19079543_ChIP-ChIP_MESCs_Mouse1.91838918
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.90923078
44* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89656271
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.89376497
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.85588362
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.85243333
48FLI1_27457419_Chip-Seq_LIVER_Mouse1.83864315
49ZFP57_27257070_Chip-Seq_ESCs_Mouse1.81732370
50PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.81458006
51CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.79899032
52ZNF274_21170338_ChIP-Seq_K562_Hela1.77271110
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.76500777
54WT1_19549856_ChIP-ChIP_CCG9911_Human1.76073814
55IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.75770049
56POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74698131
57GBX2_23144817_ChIP-Seq_PC3_Human1.71297286
58GATA1_22025678_ChIP-Seq_K562_Human1.71186214
59MYC_18358816_ChIP-ChIP_MESCs_Mouse1.70923770
60DCP1A_22483619_ChIP-Seq_HELA_Human1.70718356
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.68774713
62CDX2_19796622_ChIP-Seq_MESCs_Mouse1.67372489
63NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.66890182
64STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.66161368
65ELF1_17652178_ChIP-ChIP_JURKAT_Human1.63547158
66* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62158794
67KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.61621469
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.59514859
69FOXM1_23109430_ChIP-Seq_U2OS_Human1.59197946
70TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.57252160
71* GABP_19822575_ChIP-Seq_HepG2_Human1.55922629
72EZH2_27294783_Chip-Seq_NPCs_Mouse1.53674183
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.53014363
74EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.51014673
75NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.49766466
76SALL4_18804426_ChIP-ChIP_XEN_Mouse1.49375125
77CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.47915207
78KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.46555473
79KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.46555473
80KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.46555473
81FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46186646
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46013412
83E2F7_22180533_ChIP-Seq_HELA_Human1.45446923
84P300_19829295_ChIP-Seq_ESCs_Human1.45342029
85MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.44790275
86E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43983177
87E2F1_18555785_Chip-Seq_ESCs_Mouse1.43681234
88EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.43509282
89TP53_16413492_ChIP-PET_HCT116_Human1.43257456
90MYC_18940864_ChIP-ChIP_HL60_Human1.39187837
91CJUN_26792858_Chip-Seq_BT549_Human1.39058467
92E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.38038814
93TTF2_22483619_ChIP-Seq_HELA_Human1.37746205
94STAT3_18555785_Chip-Seq_ESCs_Mouse1.36893575
95TAF15_26573619_Chip-Seq_HEK293_Human1.36070164
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.35508881
97NOTCH1_21737748_ChIP-Seq_TLL_Human1.34365624
98MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.33836853
99SUZ12_18555785_Chip-Seq_ESCs_Mouse1.33552187
100RBPJ_22232070_ChIP-Seq_NCS_Mouse1.33437402
101ZNF217_24962896_ChIP-Seq_MCF-7_Human1.33270643
102CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.33013711
103CMYC_18555785_Chip-Seq_ESCs_Mouse1.32857689
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.32514712
105* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31985057
106P53_22387025_ChIP-Seq_ESCs_Mouse1.31445442
107SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30361965
108PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29118608
109RNF2_27304074_Chip-Seq_NSC_Mouse1.27121917
110VDR_22108803_ChIP-Seq_LS180_Human1.26255069
111TP53_18474530_ChIP-ChIP_U2OS_Human1.24536539
112POU5F1_16153702_ChIP-ChIP_HESCs_Human1.24067393
113KDM5A_27292631_Chip-Seq_BREAST_Human1.20999184
114BRD4_25478319_ChIP-Seq_HGPS_Human1.20298750
115NMYC_18555785_Chip-Seq_ESCs_Mouse1.18872005
116EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18669650
117VDR_24787735_ChIP-Seq_THP-1_Human1.18630333
118P300_18555785_Chip-Seq_ESCs_Mouse1.18202227
119OCT4_18555785_Chip-Seq_ESCs_Mouse1.18021059
120SRF_21415370_ChIP-Seq_HL-1_Mouse1.17916447
121E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17623500
122HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15799766
123ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.15681246
124HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.15433157
125CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.13678594
126FOXM1_26456572_ChIP-Seq_MCF-7_Human1.12443929
127PU1_27457419_Chip-Seq_LIVER_Mouse1.12285878
128PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.12208619
129STAT3_23295773_ChIP-Seq_U87_Human1.11241628
130SOX2_18555785_Chip-Seq_ESCs_Mouse1.09289080
131* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.09043873
132ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07637188
133SMAD4_21799915_ChIP-Seq_A2780_Human1.07332324
134RUNX1_27457419_Chip-Seq_LIVER_Mouse1.07100250
135NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06987107
136NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06987107
137ER_23166858_ChIP-Seq_MCF-7_Human1.06975535
138PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06973921
139SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06951500
140ZFX_18555785_Chip-Seq_ESCs_Mouse1.06930600
141FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.05963916
142SMAD3_21741376_ChIP-Seq_EPCs_Human1.05050914
143ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04675759
144BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03765882
145KLF4_18555785_Chip-Seq_ESCs_Mouse1.03458725
146ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02947638
147ESRRB_18555785_Chip-Seq_ESCs_Mouse1.02783910
148CDX2_22108803_ChIP-Seq_LS180_Human1.02692645
149POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02200785
150TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02200785
151* XRN2_22483619_ChIP-Seq_HELA_Human1.02163256
152ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.02010011
153NANOG_16153702_ChIP-ChIP_HESCs_Human1.01316904
154CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00610703
155PU_27001747_Chip-Seq_BMDM_Mouse1.00080722
156STAT6_21828071_ChIP-Seq_BEAS2B_Human0.98989396
157OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96655644
158TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.96464724
159* TAL1_26923725_Chip-Seq_HPCs_Mouse0.96068549
160SOX2_16153702_ChIP-ChIP_HESCs_Human0.89877678
161SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.88331889
162CIITA_25753668_ChIP-Seq_RAJI_Human0.85840162
163TFEB_21752829_ChIP-Seq_HELA_Human0.85515087
164POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.84069334
165CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.81129895
166DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.78934861
167YY1_21170310_ChIP-Seq_MESCs_Mouse0.77916252
168SOX17_20123909_ChIP-Seq_XEN_Mouse0.77772710
169SALL4_22934838_ChIP-ChIP_CD34+_Human0.77182705
170IRF1_19129219_ChIP-ChIP_H3396_Human0.76988242
171PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.73694831
172UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.72485876
173CBP_20019798_ChIP-Seq_JUKART_Human0.71726361
174IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.71726361
175RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.71361657
176NANOG_18555785_ChIP-Seq_MESCs_Mouse0.70925116
177CHD1_26751641_Chip-Seq_LNCaP_Human0.69844202

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.80104023
2MP0004957_abnormal_blastocyst_morpholog3.79489515
3MP0000569_abnormal_digit_pigmentation3.45298699
4MP0005257_abnormal_intraocular_pressure2.86629764
5MP0008932_abnormal_embryonic_tissue2.48332584
6MP0003787_abnormal_imprinting2.37779609
7MP0003121_genomic_imprinting2.33682408
8MP0002277_abnormal_respiratory_mucosa2.21692074
9MP0003786_premature_aging2.13515995
10MP0005171_absent_coat_pigmentation2.00524006
11MP0008877_abnormal_DNA_methylation1.95553490
12MP0001835_abnormal_antigen_presentation1.92220193
13MP0001730_embryonic_growth_arrest1.91134491
14MP0003136_yellow_coat_color1.90562543
15MP0002148_abnormal_hypersensitivity_rea1.88853002
16MP0008057_abnormal_DNA_replication1.87131880
17MP0008789_abnormal_olfactory_epithelium1.86823026
18MP0005379_endocrine/exocrine_gland_phen1.77591256
19MP0002163_abnormal_gland_morphology1.69163835
20MP0008995_early_reproductive_senescence1.68923633
21MP0001929_abnormal_gametogenesis1.65635963
22MP0001672_abnormal_embryogenesis/_devel1.65162430
23MP0005380_embryogenesis_phenotype1.65162430
24MP0006292_abnormal_olfactory_placode1.64520469
25MP0003123_paternal_imprinting1.63674119
26MP0003890_abnormal_embryonic-extraembry1.63309218
27MP0005394_taste/olfaction_phenotype1.62961345
28MP0005499_abnormal_olfactory_system1.62961345
29MP0002009_preneoplasia1.62073178
30MP0000350_abnormal_cell_proliferation1.59879124
31MP0003122_maternal_imprinting1.56925229
32MP0003567_abnormal_fetal_cardiomyocyte1.56685961
33MP0001915_intracranial_hemorrhage1.56635430
34MP0001697_abnormal_embryo_size1.56278375
35MP0006082_CNS_inflammation1.54316424
36MP0002102_abnormal_ear_morphology1.52063458
37MP0002419_abnormal_innate_immunity1.49774483
38MP0002084_abnormal_developmental_patter1.49767293
39MP0003937_abnormal_limbs/digits/tail_de1.48764599
40MP0010352_gastrointestinal_tract_polyps1.46990806
41MP0005076_abnormal_cell_differentiation1.45612365
42MP0010307_abnormal_tumor_latency1.42224660
43MP0003984_embryonic_growth_retardation1.41125901
44MP0002877_abnormal_melanocyte_morpholog1.38391577
45MP0005408_hypopigmentation1.37061363
46MP0002088_abnormal_embryonic_growth/wei1.35613189
47MP0006035_abnormal_mitochondrial_morpho1.34947327
48MP0005367_renal/urinary_system_phenotyp1.33363056
49MP0000516_abnormal_urinary_system1.33363056
50MP0001119_abnormal_female_reproductive1.32878549
51MP0005310_abnormal_salivary_gland1.32836789
52MP0001145_abnormal_male_reproductive1.32619432
53MP0008007_abnormal_cellular_replicative1.32333897
54MP0005451_abnormal_body_composition1.31186821
55MP0003943_abnormal_hepatobiliary_system1.30848472
56MP0002085_abnormal_embryonic_tissue1.30531947
57MP0006054_spinal_hemorrhage1.29992859
58MP0003436_decreased_susceptibility_to1.28420065
59MP0002080_prenatal_lethality1.27346972
60MP0000653_abnormal_sex_gland1.26210990
61MP0004197_abnormal_fetal_growth/weight/1.25297341
62MP0003718_maternal_effect1.24862390
63MP0003385_abnormal_body_wall1.23723896
64MP0005387_immune_system_phenotype1.22819916
65MP0001790_abnormal_immune_system1.22819916
66MP0000432_abnormal_head_morphology1.22710492
67MP0002452_abnormal_antigen_presenting1.22224986
68MP0000015_abnormal_ear_pigmentation1.21847750
69MP0000767_abnormal_smooth_muscle1.20602173
70MP0001346_abnormal_lacrimal_gland1.20523220
71MP0004264_abnormal_extraembryonic_tissu1.20516405
72MP0000427_abnormal_hair_cycle1.19427476
73MP0005197_abnormal_uvea_morphology1.19280702
74MP0005000_abnormal_immune_tolerance1.18931381
75MP0009703_decreased_birth_body1.18064464
76MP0000313_abnormal_cell_death1.15779361
77MP0009785_altered_susceptibility_to1.15222017
78MP0005248_abnormal_Harderian_gland1.14445755
79MP0003221_abnormal_cardiomyocyte_apopto1.14207116
80MP0003806_abnormal_nucleotide_metabolis1.12739074
81MP0002928_abnormal_bile_duct1.12098845
82MP0002938_white_spotting1.11282477
83MP0000049_abnormal_middle_ear1.11226913
84MP0001293_anophthalmia1.10624248
85MP0002249_abnormal_larynx_morphology1.10476268
86MP0004272_abnormal_basement_membrane1.10057966
87MP0002177_abnormal_outer_ear1.10032886
88MP0010678_abnormal_skin_adnexa1.09737698
89MP0010094_abnormal_chromosome_stability1.09040046
90MP0003755_abnormal_palate_morphology1.08939343
91MP0003698_abnormal_male_reproductive1.08564846
92MP0004782_abnormal_surfactant_physiolog1.07913356
93MP0002234_abnormal_pharynx_morphology1.07499538
94MP0008058_abnormal_DNA_repair1.07085736
95MP0009250_abnormal_appendicular_skeleto1.06482294
96MP0003111_abnormal_nucleus_morphology1.06460318
97MP0001879_abnormal_lymphatic_vessel1.06044169
98MP0000372_irregular_coat_pigmentation1.05205424
99MP0003119_abnormal_digestive_system1.04484815
100MP0000358_abnormal_cell_content/1.04404867
101MP0009384_cardiac_valve_regurgitation1.04195519
102MP0008438_abnormal_cutaneous_collagen1.04193487
103MP0005390_skeleton_phenotype1.04084945
104MP0002723_abnormal_immune_serum1.03379819
105MP0009672_abnormal_birth_weight1.02580391
106MP0002396_abnormal_hematopoietic_system1.02161460
107MP0002233_abnormal_nose_morphology1.01962960
108MP0000566_synostosis1.01771719
109MP0003077_abnormal_cell_cycle1.01404089
110MP0003941_abnormal_skin_development1.01306766
111MP0009697_abnormal_copulation1.00712461
112MP0005503_abnormal_tendon_morphology1.00576217
113MP0002086_abnormal_extraembryonic_tissu1.00493057
114MP0002109_abnormal_limb_morphology0.99613679
115MP0005508_abnormal_skeleton_morphology0.98577769
116MP0005671_abnormal_response_to0.98115511
117MP0002697_abnormal_eye_size0.97656271
118MP0001851_eye_inflammation0.97199549
119MP0005058_abnormal_lysosome_morphology0.96710692
120MP0001800_abnormal_humoral_immune0.96248610
121MP0002693_abnormal_pancreas_physiology0.95394983
122MP0002116_abnormal_craniofacial_bone0.95033774
123MP0002254_reproductive_system_inflammat0.93678211
124MP0000678_abnormal_parathyroid_gland0.92959970
125MP0001533_abnormal_skeleton_physiology0.92407883
126MP0003699_abnormal_female_reproductive0.91810478
127MP0000383_abnormal_hair_follicle0.91009030
128MP0001286_abnormal_eye_development0.90407003
129MP0002161_abnormal_fertility/fecundity0.88651402
130MP0003172_abnormal_lysosome_physiology0.87920341
131MP0002113_abnormal_skeleton_development0.87857202
132MP0005025_abnormal_response_to0.87707236
133MP0004134_abnormal_chest_morphology0.87328004
134MP0002210_abnormal_sex_determination0.86911597
135MP0000428_abnormal_craniofacial_morphol0.86789026
136MP0005395_other_phenotype0.86518868
137MP0002998_abnormal_bone_remodeling0.86428739
138MP0002115_abnormal_skeleton_extremities0.86351175
139MP0002019_abnormal_tumor_incidence0.85544058
140MP0004808_abnormal_hematopoietic_stem0.84387110
141MP0003795_abnormal_bone_structure0.84269668
142MP0004510_myositis0.84080583
143MP0005174_abnormal_tail_pigmentation0.83328609
144MP0001661_extended_life_span0.80508502
145MP0005384_cellular_phenotype0.80079393
146MP0008260_abnormal_autophagy0.78678818
147MP0002006_tumorigenesis0.76650647
148MP0006072_abnormal_retinal_apoptosis0.76570393
149MP0001324_abnormal_eye_pigmentation0.76328018
150MP0002160_abnormal_reproductive_system0.75656710
151MP0006036_abnormal_mitochondrial_physio0.75569625
152MP0003950_abnormal_plasma_membrane0.74599194
153MP0000490_abnormal_crypts_of0.69445804
154MP0005389_reproductive_system_phenotype0.65307801
155MP0002751_abnormal_autonomic_nervous0.64135699
156MP0000631_abnormal_neuroendocrine_gland0.62495767
157MP0005621_abnormal_cell_physiology0.61462519
158MP0001764_abnormal_homeostasis0.61107487
159MP0010234_abnormal_vibrissa_follicle0.61052808
160MP0003935_abnormal_craniofacial_develop0.59912112
161MP0002111_abnormal_tail_morphology0.59555256
162MP0002092_abnormal_eye_morphology0.59460706
163MP0000647_abnormal_sebaceous_gland0.58264847
164MP0001529_abnormal_vocalization0.57706397
165MP0003861_abnormal_nervous_system0.57089640
166MP0004233_abnormal_muscle_weight0.55784268
167MP0005266_abnormal_metabolism0.54438032
168MP0001188_hyperpigmentation0.53745807
169MP0001919_abnormal_reproductive_system0.52829592

Predicted human phenotypes

RankGene SetZ-score
1Prostate neoplasm (HP:0100787)3.88082999
2Abnormality of the preputium (HP:0100587)3.19582507
3Recurrent abscess formation (HP:0002722)3.12634497
4Gonadotropin excess (HP:0000837)3.11139406
5Abnormality of the ileum (HP:0001549)3.09923686
6Chromsome breakage (HP:0040012)3.03625031
7Chromosomal breakage induced by crosslinking agents (HP:0003221)2.98009543
8Abnormality of the labia minora (HP:0012880)2.96378390
9Duodenal stenosis (HP:0100867)2.95473589
10Small intestinal stenosis (HP:0012848)2.95473589
11Recurrent bacterial skin infections (HP:0005406)2.95121640
12Medulloblastoma (HP:0002885)2.80007412
13Eczematoid dermatitis (HP:0000976)2.70377750
14Agnosia (HP:0010524)2.68669970
15Abnormal lung lobation (HP:0002101)2.68560144
16Cortical dysplasia (HP:0002539)2.60426112
17Rhabdomyosarcoma (HP:0002859)2.59395839
18Abnormality of the nasal septum (HP:0000419)2.57926676
19Abnormality of the duodenum (HP:0002246)2.56326282
20Mediastinal lymphadenopathy (HP:0100721)2.54876542
21Ependymoma (HP:0002888)2.48810346
22Colon cancer (HP:0003003)2.48803198
23Microvesicular hepatic steatosis (HP:0001414)2.47202227
24Spinal cord lesions (HP:0100561)2.46823773
25Syringomyelia (HP:0003396)2.46823773
26Myelodysplasia (HP:0002863)2.41682497
27Increased hepatocellular lipid droplets (HP:0006565)2.39351649
28Abnormality of methionine metabolism (HP:0010901)2.39013964
29Hematochezia (HP:0002573)2.38064684
30Ectopic kidney (HP:0000086)2.32295428
31Hyperglycinemia (HP:0002154)2.31167378
32Birth length less than 3rd percentile (HP:0003561)2.29553032
33Systemic lupus erythematosus (HP:0002725)2.26107878
34Thick nail (HP:0001805)2.25158125
35Embryonal renal neoplasm (HP:0011794)2.24669099
36Nephroblastoma (Wilms tumor) (HP:0002667)2.23591061
37Absent radius (HP:0003974)2.23089548
38Abnormality of the fingertips (HP:0001211)2.22849935
39Horseshoe kidney (HP:0000085)2.22277272
40Abnormality of incisor morphology (HP:0011063)2.21949303
41Sloping forehead (HP:0000340)2.21550323
42Multiple enchondromatosis (HP:0005701)2.21353525
43Disinhibition (HP:0000734)2.17654095
44Subacute progressive viral hepatitis (HP:0006572)2.15830673
45Increased nuchal translucency (HP:0010880)2.15146900
46White forelock (HP:0002211)2.14693956
47Papillary thyroid carcinoma (HP:0002895)2.14000996
48Methylmalonic acidemia (HP:0002912)2.13197806
49Tetraparesis (HP:0002273)2.11996128
50Abnormality of the frontal sinuses (HP:0002687)2.11599936
51Thyroid carcinoma (HP:0002890)2.09531142
52Absent forearm bone (HP:0003953)2.08247997
53Aplasia involving forearm bones (HP:0009822)2.08247997
54Triphalangeal thumb (HP:0001199)2.08151815
55Neoplasm of the tracheobronchial system (HP:0100552)2.07899090
56Recurrent pneumonia (HP:0006532)2.07713862
57Selective tooth agenesis (HP:0001592)2.07704613
58Patchy hypopigmentation of hair (HP:0011365)2.04713492
59Recurrent gram-negative bacterial infections (HP:0005420)2.02127821
60Midline defect of the nose (HP:0004122)2.01739204
61Sensory axonal neuropathy (HP:0003390)2.01621435
62Optic neuritis (HP:0100653)2.00437467
63Retrobulbar optic neuritis (HP:0100654)2.00437467
64Lipid accumulation in hepatocytes (HP:0006561)2.00186307
65Abnormality of serum amino acid levels (HP:0003112)1.98702456
66Metaphyseal dysplasia (HP:0100255)1.98200305
67Spastic diplegia (HP:0001264)1.97349965
68Cafe-au-lait spot (HP:0000957)1.97136826
69Capillary hemangiomas (HP:0005306)1.96233013
70Congenital sensorineural hearing impairment (HP:0008527)1.95577120
71Pathologic fracture (HP:0002756)1.93892299
72Alveolar cell carcinoma (HP:0006519)1.93156826
73Abnormality of DNA repair (HP:0003254)1.92505814
74Abnormal hair whorl (HP:0010721)1.92051422
75Abnormality of chromosome stability (HP:0003220)1.91018187
76Cellular immunodeficiency (HP:0005374)1.90820247
77Urethral obstruction (HP:0000796)1.90162513
78Neoplasm of the colon (HP:0100273)1.89425542
79Abnormality of homocysteine metabolism (HP:0010919)1.89360456
80Homocystinuria (HP:0002156)1.89360456
81Oligodactyly (hands) (HP:0001180)1.88437257
82Deep philtrum (HP:0002002)1.88065490
83Limb hypertonia (HP:0002509)1.87687909
84Embryonal neoplasm (HP:0002898)1.87658240
85Absent eyebrow (HP:0002223)1.86734921
86Male infertility (HP:0003251)1.86600262
87Type I transferrin isoform profile (HP:0003642)1.86466768
88Absent frontal sinuses (HP:0002688)1.86197815
89Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85980779
90Facial cleft (HP:0002006)1.85764625
91Bifid tongue (HP:0010297)1.85638728
92Short middle phalanx of the 5th finger (HP:0004220)1.84629899
93Anomalous pulmonary venous return (HP:0010772)1.83362610
94Choanal atresia (HP:0000453)1.82943677
95Cupped ear (HP:0000378)1.82444936
96Glioma (HP:0009733)1.81784813
97Acute myeloid leukemia (HP:0004808)1.80650367
98Progressive external ophthalmoplegia (HP:0000590)1.80649066
99Bone pain (HP:0002653)1.80607832
100Astrocytoma (HP:0009592)1.80438095
101Abnormality of the astrocytes (HP:0100707)1.80438095
102Aplasia/Hypoplasia of the earlobes (HP:0009906)1.78735424
103Preauricular pit (HP:0004467)1.78675928
104Periauricular skin pits (HP:0100277)1.78675928
105Chronic hepatic failure (HP:0100626)1.78652114
106Poikiloderma (HP:0001029)1.78550721
107Lip pit (HP:0100267)1.78365134
108Orchitis (HP:0100796)1.77559124
109Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.76767303
110Aplasia/Hypoplasia of the sacrum (HP:0008517)1.76288144
111Short tibia (HP:0005736)1.76044545
112Ovarian neoplasm (HP:0100615)1.76019414
113Neoplasm of the small intestine (HP:0100833)1.75635069
114Enlarged epiphyses (HP:0010580)1.75230625
115Tubulointerstitial nephritis (HP:0001970)1.75169473
116Stomach cancer (HP:0012126)1.74831029
117Abnormality of the prostate (HP:0008775)1.74748167
118Megaloblastic anemia (HP:0001889)1.74669554
119Abnormality of the pulmonary veins (HP:0011718)1.73716341
120Flat capital femoral epiphysis (HP:0003370)1.73709219
121Volvulus (HP:0002580)1.73080669
122Epiphyseal dysplasia (HP:0002656)1.72501058
123Occipital encephalocele (HP:0002085)1.71950831
124Leiomyosarcoma (HP:0100243)1.70596280
125Uterine leiomyosarcoma (HP:0002891)1.70596280
126Aplasia/Hypoplasia of the tibia (HP:0005772)1.69380848
127Glomerulonephritis (HP:0000099)1.68543201
128Delayed epiphyseal ossification (HP:0002663)1.66817067
129Adrenal hypoplasia (HP:0000835)1.66305977
130Abnormality of alanine metabolism (HP:0010916)1.66011323
131Hyperalaninemia (HP:0003348)1.66011323
132Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.66011323
133Abnormality of the carotid arteries (HP:0005344)1.64895643
134Aplasia cutis congenita (HP:0001057)1.64299073
135Impulsivity (HP:0100710)1.64113868
136Preaxial hand polydactyly (HP:0001177)1.63340750
137Osteomalacia (HP:0002749)1.63218151
138Microglossia (HP:0000171)1.62911393
139Aplastic anemia (HP:0001915)1.62851113
140Abnormality of the anterior horn cell (HP:0006802)1.62640034
141Degeneration of anterior horn cells (HP:0002398)1.62640034
142Absent speech (HP:0001344)1.62538790
143Hypoplastic pelvis (HP:0008839)1.62017790
144Gingivitis (HP:0000230)1.61755138
145Biliary tract neoplasm (HP:0100574)1.61201101
146Long clavicles (HP:0000890)1.60175218
147Pulmonary infiltrates (HP:0002113)1.59974280
148Duplicated collecting system (HP:0000081)1.58591536
149Abnormal protein glycosylation (HP:0012346)1.58032779
150Abnormal glycosylation (HP:0012345)1.58032779
151Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.58032779
152Abnormal protein N-linked glycosylation (HP:0012347)1.58032779
153Increased intramyocellular lipid droplets (HP:0012240)1.57708974
154Hypoplastic iliac wings (HP:0002866)1.57681107
155Increased serum lactate (HP:0002151)1.57526971
156Asymmetry of the thorax (HP:0001555)1.57410463
157Abnormality of the vitamin B12 metabolism (HP:0004341)1.56531927
158Hypoplastic ischia (HP:0003175)1.56169239
159Transitional cell carcinoma of the bladder (HP:0006740)1.55988432
160Median cleft lip (HP:0000161)1.55925416
161Hypergonadotropic hypogonadism (HP:0000815)1.55016826
162Periodontitis (HP:0000704)1.54977366
163Submucous cleft hard palate (HP:0000176)1.54499922
164Intestinal atresia (HP:0011100)1.54343804
165Aseptic necrosis (HP:0010885)1.54172532
166Meckel diverticulum (HP:0002245)1.54037857
167Hypoplastic labia majora (HP:0000059)1.52869528
168Abnormality of macrophages (HP:0004311)1.51609468
169Clubbing of toes (HP:0100760)1.51432887
170Inappropriate behavior (HP:0000719)1.50585775
171Aplasia/Hypoplasia of the uvula (HP:0010293)1.49005013
172Myelomeningocele (HP:0002475)1.47973375
173Abnormality of the intervertebral disk (HP:0005108)1.43287754
174Premature loss of primary teeth (HP:0006323)1.42730578
175Supernumerary spleens (HP:0009799)1.42113088
176Intestinal fistula (HP:0100819)1.42106461
177Abnormality of the ischium (HP:0003174)1.42002326
178Abnormality of the renal collecting system (HP:0004742)1.41633232
179Basal ganglia calcification (HP:0002135)1.41349929
180Abnormal pancreas size (HP:0012094)1.40498079
181Hypoplasia of the iris (HP:0007676)1.39832377
182Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.39544047
183Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.39330054

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.85451610
2BMPR23.74594082
3LATS13.51292850
4TAOK33.04546082
5MAP3K142.91475389
6CDK122.85271898
7TSSK62.67938218
8BMPR1B2.51485523
9NUAK12.36524659
10EIF2AK12.15806238
11STK32.11507829
12PLK42.06711831
13IRAK42.06589000
14CDK82.02337456
15TRIM281.95736845
16INSRR1.85699819
17MAP4K21.82520353
18CDC71.82216088
19NEK11.75695352
20MOS1.70649874
21CDK191.67235589
22PLK11.62781565
23ERBB31.62066687
24PLK21.59937381
25RIPK41.57986444
26MAP3K41.56739426
27MAPK151.56301231
28BRD41.54083353
29CHUK1.52909270
30ACVR1B1.49091846
31EIF2AK31.45344016
32STK38L1.44361864
33WEE11.42169648
34TTK1.38702879
35MUSK1.36826761
36JAK31.33201696
37IRAK31.32121887
38IKBKB1.30581014
39ZAK1.23622226
40BRSK21.21857610
41NEK91.20501178
42WNK31.19688466
43NLK1.19592668
44CASK1.19019567
45STK241.18375679
46TYK21.14923684
47STK161.14604476
48MELK1.12751245
49TGFBR21.11532993
50YES11.10234606
51CDK91.09629234
52TNIK1.08377418
53TRPM71.07892600
54PNCK1.07386356
55BLK1.05399435
56CDK31.04399113
57MAP3K131.03355124
58EIF2AK21.02340602
59TXK1.02111114
60AURKB1.01376403
61PBK0.99824223
62MAP3K30.99773717
63CSNK1G10.98877613
64OXSR10.98643028
65ERBB40.98344195
66MAP3K90.95799739
67IKBKE0.95306761
68PDK20.91867448
69TNK20.91765345
70RAF10.91719057
71RPS6KA40.90514350
72SGK20.90337538
73AKT30.90093954
74TGFBR10.86124459
75MAP3K60.85161836
76FRK0.83677694
77CSNK1G20.83084554
78TBK10.83064398
79MKNK10.83037012
80BCR0.82959622
81CAMK1G0.82140643
82CHEK20.81732504
83SIK30.81321811
84TAF10.81095673
85NEK60.80668525
86NEK20.79885871
87CSNK1G30.79287384
88STK100.78608555
89SCYL20.78101429
90ATM0.77770331
91GRK70.76549905
92ATR0.75770442
93STK390.75340168
94MAP3K20.75088880
95MST40.74728444
96MAPK130.74214308
97MKNK20.74081097
98PASK0.73452899
99MARK30.73176613
100BRAF0.72416504
101ADRBK20.71795525
102FLT30.71529688
103FGFR10.70600608
104PDGFRB0.70238899
105CSNK1A1L0.70170814
106MET0.69061581
107ALK0.68710766
108MAP3K120.68499305
109VRK10.67126351
110AURKA0.66791093
111MAP2K20.66449534
112CAMK1D0.63904542
113CDK60.63865839
114CSNK2A20.63738312
115DYRK30.63449077
116CDK20.63321807
117PDGFRA0.62266649
118CSNK1E0.61257133
119CDK10.60730484
120CLK10.59989772
121CDK40.59612859
122PIK3CA0.58678897
123RPS6KB20.57749454
124EPHA30.57612232
125JAK10.57081104
126SRPK10.56749946
127BRSK10.55605961
128PLK30.54941462
129HIPK20.54356886
130CDK70.53791939
131NME10.52596555
132STK40.51855359
133CSNK2A10.51422657
134DYRK20.49323393
135KSR10.48813751
136FGR0.46722149
137MAP3K100.46359313
138IGF1R0.45837173
139DYRK1A0.45299866
140LYN0.44768323
141MAPKAPK20.44634371
142TEC0.43546310
143PRKD20.43006182
144MAPK70.42971717
145CSF1R0.42494869
146MAP2K10.41203490
147IRAK10.41090432
148SIK20.40805551
149EGFR0.40786141
150CHEK10.40436371
151PRKACB0.40329961
152RPS6KA50.40136521
153PIM10.39504345
154AKT10.39337149
155ABL10.38954511
156MAPK140.38063956
157PKN10.37363622
158PRKDC0.37190147

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.16097005
2DNA replication_Homo sapiens_hsa030304.14314597
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.89918271
4Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.07981828
5RNA transport_Homo sapiens_hsa030132.94719933
6Base excision repair_Homo sapiens_hsa034102.64034811
7Spliceosome_Homo sapiens_hsa030402.56159996
8Nucleotide excision repair_Homo sapiens_hsa034202.50580669
9Proteasome_Homo sapiens_hsa030502.40569480
10RNA polymerase_Homo sapiens_hsa030202.24016415
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.06695953
12Staphylococcus aureus infection_Homo sapiens_hsa051502.03984645
13Toll-like receptor signaling pathway_Homo sapiens_hsa046201.98502691
14NOD-like receptor signaling pathway_Homo sapiens_hsa046211.87579756
15Allograft rejection_Homo sapiens_hsa053301.77260925
16Leishmaniasis_Homo sapiens_hsa051401.76184194
17Graft-versus-host disease_Homo sapiens_hsa053321.75881641
18Non-homologous end-joining_Homo sapiens_hsa034501.74628512
19Influenza A_Homo sapiens_hsa051641.74506052
20Herpes simplex infection_Homo sapiens_hsa051681.71932289
21Cysteine and methionine metabolism_Homo sapiens_hsa002701.67339385
22Protein export_Homo sapiens_hsa030601.65546484
23Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.62635976
24Measles_Homo sapiens_hsa051621.60520405
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.58946956
26Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.57752833
27Propanoate metabolism_Homo sapiens_hsa006401.56419478
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.55415947
29Selenocompound metabolism_Homo sapiens_hsa004501.52469760
30Pyrimidine metabolism_Homo sapiens_hsa002401.52274545
31Basal transcription factors_Homo sapiens_hsa030221.50942524
32Osteoclast differentiation_Homo sapiens_hsa043801.48283918
33TNF signaling pathway_Homo sapiens_hsa046681.44629953
34Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44399505
35Type I diabetes mellitus_Homo sapiens_hsa049401.43787896
36Oocyte meiosis_Homo sapiens_hsa041141.41667759
37Glycosaminoglycan degradation_Homo sapiens_hsa005311.40217953
38Legionellosis_Homo sapiens_hsa051341.39827067
39Ribosome_Homo sapiens_hsa030101.37549174
40Transcriptional misregulation in cancer_Homo sapiens_hsa052021.37513083
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.32991027
42Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30043241
43TGF-beta signaling pathway_Homo sapiens_hsa043501.29711606
44Malaria_Homo sapiens_hsa051441.29319928
45Rheumatoid arthritis_Homo sapiens_hsa053231.27873835
46Pertussis_Homo sapiens_hsa051331.26426574
47Toxoplasmosis_Homo sapiens_hsa051451.24776235
48Intestinal immune network for IgA production_Homo sapiens_hsa046721.24100609
49Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.23288679
50Fanconi anemia pathway_Homo sapiens_hsa034601.22447959
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21245883
52Steroid biosynthesis_Homo sapiens_hsa001001.20510108
53Autoimmune thyroid disease_Homo sapiens_hsa053201.19856369
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.18784745
55MicroRNAs in cancer_Homo sapiens_hsa052061.18473356
56Purine metabolism_Homo sapiens_hsa002301.17213173
57Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.16658362
58Cell cycle_Homo sapiens_hsa041101.14759198
59Tuberculosis_Homo sapiens_hsa051521.14597525
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12713310
61Adherens junction_Homo sapiens_hsa045201.09819326
62Small cell lung cancer_Homo sapiens_hsa052221.05359252
63RNA degradation_Homo sapiens_hsa030181.01310736
64Phagosome_Homo sapiens_hsa041450.99842689
65Sphingolipid metabolism_Homo sapiens_hsa006000.99837403
66Ovarian steroidogenesis_Homo sapiens_hsa049130.99804722
67Hepatitis B_Homo sapiens_hsa051610.99799727
68Other glycan degradation_Homo sapiens_hsa005110.98253567
69Prostate cancer_Homo sapiens_hsa052150.97637648
70Apoptosis_Homo sapiens_hsa042100.97073219
71Asthma_Homo sapiens_hsa053100.96777662
72Lysosome_Homo sapiens_hsa041420.96461129
73African trypanosomiasis_Homo sapiens_hsa051430.91039670
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.90971519
75Prolactin signaling pathway_Homo sapiens_hsa049170.90917040
76Ether lipid metabolism_Homo sapiens_hsa005650.88335468
77Homologous recombination_Homo sapiens_hsa034400.86821877
78Notch signaling pathway_Homo sapiens_hsa043300.86751899
79Pyruvate metabolism_Homo sapiens_hsa006200.85441174
80Folate biosynthesis_Homo sapiens_hsa007900.85400233
81Hepatitis C_Homo sapiens_hsa051600.84353680
82Pancreatic cancer_Homo sapiens_hsa052120.83953674
83Huntingtons disease_Homo sapiens_hsa050160.83640228
84Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83454841
85p53 signaling pathway_Homo sapiens_hsa041150.83150813
86Hematopoietic cell lineage_Homo sapiens_hsa046400.80715905
87Regulation of autophagy_Homo sapiens_hsa041400.80483470
88Chemokine signaling pathway_Homo sapiens_hsa040620.80280641
89Amoebiasis_Homo sapiens_hsa051460.78738798
90One carbon pool by folate_Homo sapiens_hsa006700.78232600
91Thyroid cancer_Homo sapiens_hsa052160.77020434
92Arachidonic acid metabolism_Homo sapiens_hsa005900.76860948
93HTLV-I infection_Homo sapiens_hsa051660.74439829
94ECM-receptor interaction_Homo sapiens_hsa045120.74092228
95Jak-STAT signaling pathway_Homo sapiens_hsa046300.73893019
96Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.73326749
97Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.73038176
98N-Glycan biosynthesis_Homo sapiens_hsa005100.72494720
99Biosynthesis of amino acids_Homo sapiens_hsa012300.70686186
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70117637
101Chronic myeloid leukemia_Homo sapiens_hsa052200.70106585
102Fatty acid elongation_Homo sapiens_hsa000620.70099693
103Parkinsons disease_Homo sapiens_hsa050120.70009452
104Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68847142
105Antigen processing and presentation_Homo sapiens_hsa046120.64919323
106Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64705323
107B cell receptor signaling pathway_Homo sapiens_hsa046620.64113392
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63618601
109mRNA surveillance pathway_Homo sapiens_hsa030150.63581946
110Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.63073061
111FoxO signaling pathway_Homo sapiens_hsa040680.62946805
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.62438789
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.62312017
114Hippo signaling pathway_Homo sapiens_hsa043900.61185927
115Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58664085
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57577537
117Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57055490
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.56979007
119Viral carcinogenesis_Homo sapiens_hsa052030.56203686
120Salmonella infection_Homo sapiens_hsa051320.56003740
121Prion diseases_Homo sapiens_hsa050200.55521145
122Carbon metabolism_Homo sapiens_hsa012000.55262190
123Basal cell carcinoma_Homo sapiens_hsa052170.54693621
124Epstein-Barr virus infection_Homo sapiens_hsa051690.54335829
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53545063
126Lysine degradation_Homo sapiens_hsa003100.52357801
127Viral myocarditis_Homo sapiens_hsa054160.52182985
128Melanoma_Homo sapiens_hsa052180.51924538
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.50937580
130Pathways in cancer_Homo sapiens_hsa052000.50520722
131Proteoglycans in cancer_Homo sapiens_hsa052050.48959702
132Mineral absorption_Homo sapiens_hsa049780.47828808
133Oxidative phosphorylation_Homo sapiens_hsa001900.47773682
134Type II diabetes mellitus_Homo sapiens_hsa049300.47673577
135Complement and coagulation cascades_Homo sapiens_hsa046100.47385765
136Focal adhesion_Homo sapiens_hsa045100.47025852
137Colorectal cancer_Homo sapiens_hsa052100.46713287
138Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44689339
139Wnt signaling pathway_Homo sapiens_hsa043100.44669493
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.44435796
141Dorso-ventral axis formation_Homo sapiens_hsa043200.44140370
142Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.43613285
143Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42254630
144Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39949493
145Metabolic pathways_Homo sapiens_hsa011000.36698548
146Olfactory transduction_Homo sapiens_hsa047400.36272487
147Endometrial cancer_Homo sapiens_hsa052130.34785562
148Glutathione metabolism_Homo sapiens_hsa004800.33596363
149Non-small cell lung cancer_Homo sapiens_hsa052230.31372369
150Drug metabolism - other enzymes_Homo sapiens_hsa009830.30385885
151Vitamin digestion and absorption_Homo sapiens_hsa049770.25118685
152Fatty acid biosynthesis_Homo sapiens_hsa000610.23416181
153Systemic lupus erythematosus_Homo sapiens_hsa053220.23414754
154Inositol phosphate metabolism_Homo sapiens_hsa005620.22399672
155Caffeine metabolism_Homo sapiens_hsa002320.22290934
156mTOR signaling pathway_Homo sapiens_hsa041500.18110575
157Fatty acid metabolism_Homo sapiens_hsa012120.18025304
158Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.17583099
159Central carbon metabolism in cancer_Homo sapiens_hsa052300.17173466
160Taste transduction_Homo sapiens_hsa047420.16375445
161Alzheimers disease_Homo sapiens_hsa050100.16116651
162Circadian rhythm_Homo sapiens_hsa047100.10884107
163Phototransduction_Homo sapiens_hsa047440.08748449

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