ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cilium movement (GO:0003341)	9.77536261
2	left/right axis specification (GO:0070986)	7.57548710
3	lateral ventricle development (GO:0021670)	6.96828024
4	cytoplasmic mRNA processing body assembly (GO:0033962)	5.39430198
5	regulation of protein polyubiquitination (GO:1902914)	5.34086653
6	interkinetic nuclear migration (GO:0022027)	5.24472571
7	ventricular system development (GO:0021591)	5.20520450
8	axoneme assembly (GO:0035082)	5.06397272
9	establishment of nucleus localization (GO:0040023)	4.98330754
10	nucleus localization (GO:0051647)	4.93379995
11	UDP-N-acetylglucosamine metabolic process (GO:0006047)	4.92747430
12	mitochondrial DNA replication (GO:0006264)	4.86183015
13	signal peptide processing (GO:0006465)	4.78232772
14	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.47303804
15	neural tube formation (GO:0001841)	4.28916096
16	toxin metabolic process (GO:0009404)	4.17498734
17	regulation of hippo signaling (GO:0035330)	4.07070113
18	intraciliary transport (GO:0042073)	4.06468377
19	monoubiquitinated protein deubiquitination (GO:0035520)	3.98574927
20	positive regulation of smoothened signaling pathway (GO:0045880)	3.96646341
21	diterpenoid biosynthetic process (GO:0016102)	3.95233361
22	growth hormone receptor signaling pathway (GO:0060396)	3.94089723
23	retinal rod cell development (GO:0046548)	3.91017492
24	terpenoid biosynthetic process (GO:0016114)	3.78747565
25	one-carbon compound transport (GO:0019755)	3.74972629
26	spinal cord motor neuron differentiation (GO:0021522)	3.72916186
27	regulation of gene silencing by miRNA (GO:0060964)	3.72613404
28	regulation of gene silencing by RNA (GO:0060966)	3.72613404
29	regulation of posttranscriptional gene silencing (GO:0060147)	3.72613404
30	cGMP biosynthetic process (GO:0006182)	3.66567211
31	cellular response to growth hormone stimulus (GO:0071378)	3.54501907
32	negative regulation of DNA repair (GO:0045738)	3.50705619
33	embryonic digestive tract development (GO:0048566)	3.48242684
34	axonemal dynein complex assembly (GO:0070286)	3.48114880
35	DNA-dependent DNA replication (GO:0006261)	3.42692694
36	regulation of non-canonical Wnt signaling pathway (GO:2000050)	3.36998690
37	nuclear pore complex assembly (GO:0051292)	3.35129905
38	regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)	3.33738051
39	positive regulation of cGMP biosynthetic process (GO:0030828)	3.33374838
40	positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)	3.31276433
41	replicative senescence (GO:0090399)	3.26337628
42	positive regulation of DNA-templated transcription, initiation (GO:2000144)	3.25055638
43	positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)	3.24108364
44	epithelial cilium movement (GO:0003351)	3.22065273
45	regulation of odontogenesis (GO:0042481)	3.18251114
46	retinal cone cell development (GO:0046549)	3.18213831
47	photoreceptor cell maintenance (GO:0045494)	3.12845373
48	relaxation of smooth muscle (GO:0044557)	3.11346178
49	regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035358)	3.10141725
50	synapsis (GO:0007129)	3.08824944
51	regulation of cGMP biosynthetic process (GO:0030826)	3.07764811
52	cilium organization (GO:0044782)	3.02149198
53	regulation of establishment of cell polarity (GO:2000114)	3.01451884
54	mitochondrial DNA metabolic process (GO:0032042)	2.99899690
55	regulation of apoptotic cell clearance (GO:2000425)	2.99559700
56	nuclear pore organization (GO:0006999)	2.97709540
57	ethanol oxidation (GO:0006069)	2.93342050
58	positive regulation of cGMP metabolic process (GO:0030825)	2.92688405
59	cGMP metabolic process (GO:0046068)	2.89538776
60	respiratory tube development (GO:0030323)	2.88277174
61	fibroblast migration (GO:0010761)	2.87377137
62	indole-containing compound catabolic process (GO:0042436)	2.85752234
63	indolalkylamine catabolic process (GO:0046218)	2.85752234
64	tryptophan catabolic process (GO:0006569)	2.85752234
65	iron ion import (GO:0097286)	2.85197803
66	transepithelial transport (GO:0070633)	2.82578720
67	cellular glucuronidation (GO:0052695)	2.80579224
68	motile cilium assembly (GO:0044458)	2.80063656
69	regulation of pigment cell differentiation (GO:0050932)	2.79444977
70	microtubule-based movement (GO:0007018)	2.78309218
71	gamma-aminobutyric acid transport (GO:0015812)	2.75984974
72	tryptophan metabolic process (GO:0006568)	2.75931195
73	metanephric mesenchyme development (GO:0072075)	2.75740232
74	kynurenine metabolic process (GO:0070189)	2.75309188
75	cilium assembly (GO:0042384)	2.74531881
76	regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)	2.72408883
77	mesenchymal cell development (GO:0014031)	2.70060387
78	uronic acid metabolic process (GO:0006063)	2.68287847
79	glucuronate metabolic process (GO:0019585)	2.68287847
80	pericardium development (GO:0060039)	2.68185397
81	stem cell development (GO:0048864)	2.67004149
82	negative regulation of smooth muscle cell differentiation (GO:0051151)	2.66075529
83	myoblast migration (GO:0051451)	2.65525689
84	regulation of DNA endoreduplication (GO:0032875)	2.63198687
85	endoderm development (GO:0007492)	2.60065115
86	histone mRNA catabolic process (GO:0071044)	2.59015771
87	nitric oxide mediated signal transduction (GO:0007263)	2.58741997
88	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.58508117
89	microtubule anchoring (GO:0034453)	2.57216443
90	snRNA transcription (GO:0009301)	2.56921606
91	regulation of immunoglobulin secretion (GO:0051023)	2.54686507
92	regulation of cGMP metabolic process (GO:0030823)	2.53290062
93	definitive hemopoiesis (GO:0060216)	2.52971206
94	regulation of centrosome duplication (GO:0010824)	2.51601434
95	embryonic epithelial tube formation (GO:0001838)	2.51276275
96	intra-S DNA damage checkpoint (GO:0031573)	2.51147629
97	peristalsis (GO:0030432)	2.50929689
98	regulation of establishment or maintenance of cell polarity (GO:0032878)	2.50893045
99	gene silencing by RNA (GO:0031047)	2.49654983
100	cilium or flagellum-dependent cell motility (GO:0001539)	15.2966835

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.47822774
2	POU3F2_20337985_ChIP-ChIP_501MEL_Human	3.35948507
3	PIAS1_25552417_ChIP-Seq_VCAP_Human	3.26838291
4	VDR_22108803_ChIP-Seq_LS180_Human	3.21225022
5	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	2.93158162
6	EWS_26573619_Chip-Seq_HEK293_Human	2.70490604
7	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.70231584
8	ZNF274_21170338_ChIP-Seq_K562_Hela	2.62799198
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.56023434
10	TP53_16413492_ChIP-PET_HCT116_Human	2.52229053
11	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	2.48413569
12	FUS_26573619_Chip-Seq_HEK293_Human	2.39300392
13	GBX2_23144817_ChIP-Seq_PC3_Human	2.36768087
14	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.36171924
15	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	2.22710984
16	GATA1_22025678_ChIP-Seq_K562_Human	2.18878295
17	AR_21572438_ChIP-Seq_LNCaP_Human	2.14139372
18	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.97498506
19	STAT3_23295773_ChIP-Seq_U87_Human	1.95988029
20	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.88855954
21	SMAD4_21799915_ChIP-Seq_A2780_Human	1.87078954
22	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.86586126
23	FOXM1_26456572_ChIP-Seq_MCF-7_Human	1.84610536
24	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.84175649
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.83247410
26	P300_19829295_ChIP-Seq_ESCs_Human	1.82873639
27	AR_25329375_ChIP-Seq_VCAP_Human	1.82309494
28	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.80369771
29	TCF4_23295773_ChIP-Seq_U87_Human	1.76960017
30	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.76294141
31	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.74630345
32	TAF15_26573619_Chip-Seq_HEK293_Human	1.70948914
33	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.70239255
34	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.69069457
35	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.68317971
36	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.66721560
37	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.64985137
38	AHR_22903824_ChIP-Seq_MCF-7_Human	1.63939967
39	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.62233802
40	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.62069382
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.59022517
42	NRF2_20460467_ChIP-Seq_MEFs_Mouse	1.58343612
43	NFE2L2_20460467_ChIP-Seq_MEFs_Mouse	1.58343612
44	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.50531073
45	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.49204978
46	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.47747008
47	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.46466064
48	FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human	1.45591163
49	TCF4_22108803_ChIP-Seq_LS180_Human	1.44221142
50	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.43485670
51	ESR1_22446102_ChIP-Seq_UTERUS_Mouse	1.42098203
52	CBP_20019798_ChIP-Seq_JUKART_Human	1.41491992
53	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.41491992
54	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.40466729
55	SMAD_19615063_ChIP-ChIP_OVARY_Human	1.38552120
56	RXR_22108803_ChIP-Seq_LS180_Human	1.35655041
57	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.33978992
58	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.33978992
59	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.29288792
60	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.28270614
61	CTNNB1_20460455_ChIP-Seq_HCT116_Human	1.26347341
62	TP53_18474530_ChIP-ChIP_U2OS_Human	1.26013854
63	CDX2_22108803_ChIP-Seq_LS180_Human	1.25420614
64	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.25244460
65	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.25119387
66	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.24808181
67	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.24615053
68	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.24566702
69	RUNX2_22187159_ChIP-Seq_PCA_Human	1.23375067
70	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.20858586
71	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.19931114
72	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.19195436
73	FOXA1_25552417_ChIP-Seq_VCAP_Human	1.18308014
74	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.17024057
75	KDM5B_21448134_ChIP-Seq_MESCs_Mouse	1.15374721
76	AR_21909140_ChIP-Seq_LNCAP_Human	1.15250468
77	SOX9_26525672_Chip-Seq_HEART_Mouse	1.14316324
78	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.13828358
79	CJUN_26792858_Chip-Seq_BT549_Human	1.12891838
80	P53_22387025_ChIP-Seq_ESCs_Mouse	1.12036610
81	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.10483613
82	NANOG_19829295_ChIP-Seq_ESCs_Human	1.10166172
83	SOX2_19829295_ChIP-Seq_ESCs_Human	1.10166172
84	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.10057589
85	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.08051933
86	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.07094705
87	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.06823652
88	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.06716539
89	SMAD3_21741376_ChIP-Seq_HESCs_Human	1.06312930
90	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.05834343
91	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.04303137
92	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.03259690
93	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.02920853
94	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.01227445
95	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.00917795
96	SUZ12_18555785_Chip-Seq_ESCs_Mouse	1.00404170
97	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.99371143
98	EGR1_23403033_ChIP-Seq_LIVER_Mouse	0.98247625
99	OCT4_21477851_ChIP-Seq_ESCs_Mouse	0.98187454
100	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.96772795

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008057_abnormal_DNA_replication	5.46680379
2	MP0005503_abnormal_tendon_morphology	4.82977815
3	MP0000678_abnormal_parathyroid_gland	3.78497063
4	MP0010030_abnormal_orbit_morphology	3.57321522
5	MP0002249_abnormal_larynx_morphology	2.80150800
6	MP0005310_abnormal_salivary_gland	2.70517929
7	MP0003329_amyloid_beta_deposits	2.65519386
8	MP0002653_abnormal_ependyma_morphology	2.46926850
9	MP0002009_preneoplasia	2.30964455
10	MP0003937_abnormal_limbs/digits/tail_de	2.26801286
11	MP0001270_distended_abdomen	2.18495112
12	MP0000383_abnormal_hair_follicle	2.14586568
13	MP0005623_abnormal_meninges_morphology	1.98393359
14	MP0000534_abnormal_ureter_morphology	1.89773123
15	MP0010307_abnormal_tumor_latency	1.88242300
16	MP0009053_abnormal_anal_canal	1.72992078
17	MP0003890_abnormal_embryonic-extraembry	1.72420200
18	MP0000049_abnormal_middle_ear	1.68042082
19	MP0003195_calcinosis	1.64754267
20	MP0000681_abnormal_thyroid_gland	1.63505309
21	MP0008875_abnormal_xenobiotic_pharmacok	1.63416125
22	MP0006138_congestive_heart_failure	1.55593452
23	MP0003943_abnormal_hepatobiliary_system	1.53132608
24	MP0005408_hypopigmentation	1.51668632
25	MP0004130_abnormal_muscle_cell	1.51243467
26	MP0002233_abnormal_nose_morphology	1.48257409
27	MP0002396_abnormal_hematopoietic_system	1.46639900
28	MP0002102_abnormal_ear_morphology	1.42865086
29	MP0000569_abnormal_digit_pigmentation	1.38837059
30	MP0002108_abnormal_muscle_morphology	1.38694201
31	MP0004215_abnormal_myocardial_fiber	1.36561326
32	MP0005248_abnormal_Harderian_gland	1.34079175
33	MP0003632_abnormal_nervous_system	1.33616086
34	MP0005646_abnormal_pituitary_gland	1.30023052
35	MP0008775_abnormal_heart_ventricle	1.27705848
36	MP0002282_abnormal_trachea_morphology	1.27218259
37	MP0002109_abnormal_limb_morphology	1.25396020
38	MP0005551_abnormal_eye_electrophysiolog	1.24550873
39	MP0000604_amyloidosis	1.24088815
40	MP0000428_abnormal_craniofacial_morphol	1.22511418
41	MP0009384_cardiac_valve_regurgitation	1.21841185
42	MP0005389_reproductive_system_phenotype	1.20413301
43	MP0009250_abnormal_appendicular_skeleto	1.18161954
44	MP0000613_abnormal_salivary_gland	1.15446738
45	MP0001346_abnormal_lacrimal_gland	1.15166653
46	MP0003283_abnormal_digestive_organ	1.13566346
47	MP0003950_abnormal_plasma_membrane	1.11409351
48	MP0010678_abnormal_skin_adnexa	1.10170887
49	MP0003119_abnormal_digestive_system	1.08304404
50	MP0002876_abnormal_thyroid_physiology	1.07314694
51	MP0002160_abnormal_reproductive_system	1.07164309
52	MP0005647_abnormal_sex_gland	1.05846343
53	MP0003942_abnormal_urinary_system	1.05555928
54	MP0003935_abnormal_craniofacial_develop	0.97371429
55	MP0004808_abnormal_hematopoietic_stem	0.94970358
56	MP0001501_abnormal_sleep_pattern	0.94868171
57	MP0005171_absent_coat_pigmentation	0.94807416
58	MP0000427_abnormal_hair_cycle	0.94507879
59	MP0009780_abnormal_chondrocyte_physiolo	0.92856498
60	MP0001919_abnormal_reproductive_system	0.92342142
61	MP0003385_abnormal_body_wall	0.91791876
62	MP0003136_yellow_coat_color	0.88491116
63	MP0003936_abnormal_reproductive_system	0.87809893
64	MP0001299_abnormal_eye_distance/	0.84395869
65	MP0000462_abnormal_digestive_system	0.81944909
66	MP0005508_abnormal_skeleton_morphology	0.81886268
67	MP0000538_abnormal_urinary_bladder	0.81375159
68	MP0001485_abnormal_pinna_reflex	0.80864830
69	MP0001764_abnormal_homeostasis	0.80559846
70	MP0002896_abnormal_bone_mineralization	0.80154844
71	MP0005330_cardiomyopathy	0.79235526
72	MP0003718_maternal_effect	0.78923612
73	MP0000432_abnormal_head_morphology	0.78213490
74	MP0005085_abnormal_gallbladder_physiolo	0.77456121
75	MP0005379_endocrine/exocrine_gland_phen	0.77385222
76	MP0001756_abnormal_urination	0.76767284
77	MP0003300_gastrointestinal_ulcer	0.76417739
78	MP0006054_spinal_hemorrhage	0.76181150
79	MP0002234_abnormal_pharynx_morphology	0.75396684
80	MP0004134_abnormal_chest_morphology	0.75279507
81	MP0002332_abnormal_exercise_endurance	0.74828356
82	MP0005388_respiratory_system_phenotype	0.74588509
83	MP0002133_abnormal_respiratory_system	0.74588509
84	MP0003252_abnormal_bile_duct	0.74555217
85	MP0008007_abnormal_cellular_replicative	0.73740730
86	MP0000163_abnormal_cartilage_morphology	0.73083014
87	MP0001502_abnormal_circadian_rhythm	0.72834106
88	MP0005253_abnormal_eye_physiology	0.71029865
89	MP0002928_abnormal_bile_duct	0.70923017
90	MP0001293_anophthalmia	0.70359205
91	MP0002932_abnormal_joint_morphology	0.70169374
92	MP0000470_abnormal_stomach_morphology	0.69869215
93	MP0000631_abnormal_neuroendocrine_gland	0.69780225
94	MP0003631_nervous_system_phenotype	0.68976797
95	MP0009046_muscle_twitch	0.68825189
96	MP0003938_abnormal_ear_development	0.68038982
97	MP0004858_abnormal_nervous_system	0.67994591
98	MP0009697_abnormal_copulation	0.67979660
99	MP0000358_abnormal_cell_content/	0.67391151
100	MP0001879_abnormal_lymphatic_vessel	0.66538795

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormal ciliary motility (HP:0012262)	7.68407120
2	Abnormal respiratory motile cilium physiology (HP:0012261)	6.63785569
3	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	6.22066377
4	Rhinitis (HP:0012384)	5.11696899
5	Birth length less than 3rd percentile (HP:0003561)	4.71274303
6	Papillary thyroid carcinoma (HP:0002895)	4.07098426
7	Chronic hepatic failure (HP:0100626)	4.03554248
8	Absent/shortened dynein arms (HP:0200106)	3.82589586
9	Dynein arm defect of respiratory motile cilia (HP:0012255)	3.82589586
10	Genetic anticipation (HP:0003743)	3.71283157
11	Oligodontia (HP:0000677)	3.54477939
12	True hermaphroditism (HP:0010459)	3.54056834
13	Pancreatic fibrosis (HP:0100732)	3.45981885
14	Pancreatic cysts (HP:0001737)	3.26432534
15	Acute myeloid leukemia (HP:0004808)	3.13633576
16	Bronchiectasis (HP:0002110)	3.00639556
17	Abnormal respiratory motile cilium morphology (HP:0005938)	2.98183020
18	Abnormal respiratory epithelium morphology (HP:0012253)	2.98183020
19	Bifid tongue (HP:0010297)	2.95830141
20	Hyperventilation (HP:0002883)	2.95504082
21	Enlarged kidneys (HP:0000105)	2.93833824
22	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.89472651
23	Postaxial foot polydactyly (HP:0001830)	2.86843912
24	Dysmetric saccades (HP:0000641)	2.72121109
25	Hypoplastic labia majora (HP:0000059)	2.67526344
26	Central scotoma (HP:0000603)	2.64270857
27	Facial cleft (HP:0002006)	2.64104965
28	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.60115359
29	Furrowed tongue (HP:0000221)	2.58341206
30	Chorioretinal atrophy (HP:0000533)	2.55557531
31	Congenital hepatic fibrosis (HP:0002612)	2.45421715
32	Cystic liver disease (HP:0006706)	2.44251517
33	Thyroid carcinoma (HP:0002890)	2.42633407
34	IgA deficiency (HP:0002720)	2.41832744
35	Abnormality of the renal medulla (HP:0100957)	2.40356399
36	Glucose intolerance (HP:0000833)	2.39909893
37	Abnormality of the labia majora (HP:0012881)	2.39878570
38	Abnormal pancreas size (HP:0012094)	2.39343401
39	Nephronophthisis (HP:0000090)	2.33568117
40	Constricted visual fields (HP:0001133)	2.33350953
41	Abnormality of the renal cortex (HP:0011035)	2.31547643
42	Abnormality of the nasal septum (HP:0000419)	2.30062050
43	Abnormality of midbrain morphology (HP:0002418)	2.26053736
44	Molar tooth sign on MRI (HP:0002419)	2.26053736
45	Abnormality of secondary sexual hair (HP:0009888)	2.22521374
46	Abnormality of the axillary hair (HP:0100134)	2.22521374
47	Hepatitis (HP:0012115)	2.22160607
48	Renal dysplasia (HP:0000110)	2.22098648
49	Recurrent sinusitis (HP:0011108)	2.22003888
50	Abnormality of alanine metabolism (HP:0010916)	2.18460291
51	Hyperalaninemia (HP:0003348)	2.18460291
52	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.18460291
53	Pheochromocytoma (HP:0002666)	2.18350504
54	Median cleft lip (HP:0000161)	2.18140950
55	Scotoma (HP:0000575)	2.18051835
56	Proximal amyotrophy (HP:0007126)	2.15385841
57	Preaxial hand polydactyly (HP:0001177)	2.12996025
58	Occipital encephalocele (HP:0002085)	2.10921315
59	Chronic bronchitis (HP:0004469)	2.09002167
60	Medial flaring of the eyebrow (HP:0010747)	2.07756056
61	Truncal obesity (HP:0001956)	2.06812548
62	Abnormality of the common coagulation pathway (HP:0010990)	2.06008018
63	Vertebral arch anomaly (HP:0008438)	2.03907748
64	Poor coordination (HP:0002370)	2.02251505
65	Nasal polyposis (HP:0100582)	2.01701219
66	Abnormality of the ischium (HP:0003174)	1.98551421
67	Abnormal glucose tolerance (HP:0001952)	1.97329447
68	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.93909466
69	Increased number of teeth (HP:0011069)	1.91447278
70	Menstrual irregularities (HP:0000858)	1.91099571
71	Fibular hypoplasia (HP:0003038)	1.90057051
72	Congenital primary aphakia (HP:0007707)	1.88182851
73	Tubulointerstitial nephritis (HP:0001970)	1.85394341
74	Anophthalmia (HP:0000528)	1.82907804
75	Chromsome breakage (HP:0040012)	1.82379249
76	Sclerocornea (HP:0000647)	1.79941541
77	Congenital, generalized hypertrichosis (HP:0004540)	1.79561376
78	Abnormality of the fibula (HP:0002991)	1.76282340
79	Bony spicule pigmentary retinopathy (HP:0007737)	1.75950618
80	Congenital stationary night blindness (HP:0007642)	1.75032326
81	Metaphyseal dysplasia (HP:0100255)	1.74210399
82	Oculomotor apraxia (HP:0000657)	1.73953539
83	Gait imbalance (HP:0002141)	1.73844359
84	Cutaneous finger syndactyly (HP:0010554)	1.73447686
85	Microtia (HP:0008551)	1.73298342
86	Blue irides (HP:0000635)	1.73185260
87	Anterior segment dysgenesis (HP:0007700)	1.73155575
88	Prominent supraorbital ridges (HP:0000336)	1.72310684
89	Anencephaly (HP:0002323)	1.70451169
90	Rectal prolapse (HP:0002035)	1.70154684
91	Postaxial hand polydactyly (HP:0001162)	1.70028209
92	Nephrogenic diabetes insipidus (HP:0009806)	1.70004576
93	Chin dimple (HP:0010751)	1.69930955
94	Preaxial foot polydactyly (HP:0001841)	1.69709759
95	Hypoplastic ischia (HP:0003175)	1.68508999
96	Progressive cerebellar ataxia (HP:0002073)	1.68058432
97	Hypoplasia of the iris (HP:0007676)	1.67210473
98	Gaze-evoked nystagmus (HP:0000640)	1.67178245
99	Short chin (HP:0000331)	1.66625641
100	Abnormal rod and cone electroretinograms (HP:0008323)	1.66443382

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	8.73766010
2	ACVR1B	3.93656695
3	NUAK1	3.72045992
4	PIK3CA	3.35878795
5	STK39	2.61497892
6	TGFBR1	2.37333819
7	MKNK2	2.22268228
8	MAP3K2	2.15767108
9	LATS1	2.12427729
10	NTRK3	1.78523961
11	WNK4	1.77833217
12	BMPR1B	1.76873860
13	DMPK	1.58165992
14	PDGFRB	1.55969175
15	NEK1	1.53681681
16	AKT3	1.51578583
17	CAMKK2	1.48582705
18	PNCK	1.46648976
19	TAF1	1.46300526
20	BRSK2	1.39761423
21	MKNK1	1.34078632
22	RAF1	1.25098042
23	PLK4	1.24903366
24	OXSR1	1.22839921
25	TRPM7	1.22726933
26	WEE1	1.16402141
27	PDK2	1.14895632
28	ERBB3	1.11258679
29	MELK	1.06245470
30	MAP3K4	1.04510443
31	MAP3K7	1.00442358
32	BRD4	0.92643047
33	RET	0.91630754
34	TEC	0.84257092
35	NLK	0.82963415
36	IRAK1	0.82647791
37	WNK1	0.78964958
38	STK38L	0.78498090
39	KIT	0.78411576
40	FGFR3	0.75387527
41	DYRK1B	0.70764883
42	CDK12	0.70229165
43	BTK	0.68261686
44	STK3	0.67341632
45	ATM	0.66516049
46	MAP3K10	0.62577458
47	DAPK2	0.60706276
48	PASK	0.60126250
49	BMPR2	0.60080241
50	CDC7	0.59405331
51	FGFR2	0.58028849
52	RPS6KB2	0.57241936
53	YES1	0.57103783
54	EIF2AK3	0.56956449
55	CSNK1A1L	0.55204165
56	CAMK1D	0.53493084
57	MAP2K1	0.53478782
58	EEF2K	0.52805644
59	RPS6KA4	0.51856576
60	NEK2	0.51060622
61	PINK1	0.50929328
62	ADRBK2	0.50559091
63	MAPK15	0.50187147
64	MET	0.50014478
65	MAP2K2	0.49594838
66	MAPKAPK5	0.49527728
67	FLT3	0.47950284
68	AKT2	0.47665955
69	SGK1	0.47217234
70	MST4	0.46667485
71	STK16	0.45482123
72	TAOK3	0.44749654
73	CDK3	0.42470632
74	PRKG1	0.39898277
75	PTK6	0.39773051
76	INSR	0.38961843
77	TSSK6	0.37273326
78	JAK1	0.37261939
79	RPS6KA5	0.37042019
80	STK38	0.36608400
81	PAK3	0.36123619
82	MARK2	0.35594600
83	CSNK1E	0.35245058
84	CHEK1	0.34610605
85	MAPK11	0.34206790
86	PAK2	0.33835666
87	INSRR	0.32958535
88	PDGFRA	0.32953692
89	AURKB	0.32756443
90	JAK2	0.31840631
91	CHUK	0.31778055
92	CDK8	0.31350857
93	PTK2B	0.30961205
94	CAMK4	0.30750511
95	ABL1	0.30096275
96	EGFR	0.30033032
97	ATR	0.29957214
98	MAPK13	0.29665863
99	RPS6KB1	0.29362884
100	LCK	0.28857980

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	ABC transporters_Homo sapiens_hsa02010	3.94199151
2	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	3.47503625
3	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	3.23754409
4	Linoleic acid metabolism_Homo sapiens_hsa00591	3.06408619
5	Retinol metabolism_Homo sapiens_hsa00830	2.55645785
6	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	2.43103125
7	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	2.24668990
8	Steroid hormone biosynthesis_Homo sapiens_hsa00140	2.14498236
9	Chemical carcinogenesis_Homo sapiens_hsa05204	2.11176617
10	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.07392785
11	Tryptophan metabolism_Homo sapiens_hsa00380	1.94937831
12	Nitrogen metabolism_Homo sapiens_hsa00910	1.85073174
13	Complement and coagulation cascades_Homo sapiens_hsa04610	1.62006052
14	Small cell lung cancer_Homo sapiens_hsa05222	1.59388675
15	Fatty acid degradation_Homo sapiens_hsa00071	1.54944801
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.51436355
17	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.50533902
18	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.49776055
19	Homologous recombination_Homo sapiens_hsa03440	1.46746034
20	Caffeine metabolism_Homo sapiens_hsa00232	1.39064324
21	Huntingtons disease_Homo sapiens_hsa05016	1.38291212
22	Arginine biosynthesis_Homo sapiens_hsa00220	1.37899136
23	Propanoate metabolism_Homo sapiens_hsa00640	1.34096409
24	Non-small cell lung cancer_Homo sapiens_hsa05223	1.33367850
25	Selenocompound metabolism_Homo sapiens_hsa00450	1.31434614
26	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	1.30013476
27	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.21197100
28	Phototransduction_Homo sapiens_hsa04744	1.20266255
29	Histidine metabolism_Homo sapiens_hsa00340	1.19574951
30	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.19311121
31	TGF-beta signaling pathway_Homo sapiens_hsa04350	1.15561888
32	Salivary secretion_Homo sapiens_hsa04970	1.14986207
33	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	1.13942578
34	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.11574738
35	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.10621317
36	Asthma_Homo sapiens_hsa05310	1.08769143
37	One carbon pool by folate_Homo sapiens_hsa00670	1.08597471
38	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	1.06624418
39	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.03086397
40	Glycerolipid metabolism_Homo sapiens_hsa00561	0.99183781
41	beta-Alanine metabolism_Homo sapiens_hsa00410	0.95725759
42	Fanconi anemia pathway_Homo sapiens_hsa03460	0.93407028
43	Lysine degradation_Homo sapiens_hsa00310	0.93172660
44	Calcium signaling pathway_Homo sapiens_hsa04020	0.92501026
45	Melanoma_Homo sapiens_hsa05218	0.90900321
46	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.89549477
47	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.86211808
48	Sulfur relay system_Homo sapiens_hsa04122	0.86192248
49	Fat digestion and absorption_Homo sapiens_hsa04975	0.82683315
50	RNA degradation_Homo sapiens_hsa03018	0.82050539
51	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.81680162
52	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.81298184
53	Glioma_Homo sapiens_hsa05214	0.74889420
54	Ribosome_Homo sapiens_hsa03010	0.74674141
55	Platelet activation_Homo sapiens_hsa04611	0.74203714
56	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.73011788
57	Type II diabetes mellitus_Homo sapiens_hsa04930	0.71371883
58	Amoebiasis_Homo sapiens_hsa05146	0.70936411
59	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.70267939
60	Butanoate metabolism_Homo sapiens_hsa00650	0.69796013
61	Fatty acid metabolism_Homo sapiens_hsa01212	0.67718346
62	Pancreatic secretion_Homo sapiens_hsa04972	0.67666041
63	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.66786574
64	Olfactory transduction_Homo sapiens_hsa04740	0.65768544
65	Serotonergic synapse_Homo sapiens_hsa04726	0.64814102
66	Peroxisome_Homo sapiens_hsa04146	0.63965457
67	Transcriptional misregulation in cancer_Homo sapiens_hsa05202	0.61261693
68	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.60358938
69	Prolactin signaling pathway_Homo sapiens_hsa04917	0.59794251
70	Renin secretion_Homo sapiens_hsa04924	0.58300015
71	Taste transduction_Homo sapiens_hsa04742	0.56857726
72	Jak-STAT signaling pathway_Homo sapiens_hsa04630	0.55494811
73	Ether lipid metabolism_Homo sapiens_hsa00565	0.54514145
74	RNA transport_Homo sapiens_hsa03013	0.53304370
75	Purine metabolism_Homo sapiens_hsa00230	0.53249833
76	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.51189983
77	ErbB signaling pathway_Homo sapiens_hsa04012	0.50415435
78	AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933	0.50044363
79	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.48176124
80	Bile secretion_Homo sapiens_hsa04976	0.47362833
81	Chronic myeloid leukemia_Homo sapiens_hsa05220	0.44003542
82	Pancreatic cancer_Homo sapiens_hsa05212	0.43675014
83	Protein digestion and absorption_Homo sapiens_hsa04974	0.42862852
84	Prostate cancer_Homo sapiens_hsa05215	0.42680284
85	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.42543880
86	Toxoplasmosis_Homo sapiens_hsa05145	0.41992456
87	Long-term depression_Homo sapiens_hsa04730	0.41080671
88	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.38986769
89	Tyrosine metabolism_Homo sapiens_hsa00350	0.38653713
90	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.36815519
91	Pathways in cancer_Homo sapiens_hsa05200	0.35168845
92	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.32819408
93	Circadian rhythm_Homo sapiens_hsa04710	0.32650001
94	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.32378359
95	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.31743174
96	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.31301778
97	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.29969451
98	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.29429336
99	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.29126100
100	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.27856622

NFYAP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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