NFYB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of SSU-rRNA (GO:0030490)4.76063179
2DNA replication checkpoint (GO:0000076)4.43329228
3ribosomal small subunit biogenesis (GO:0042274)4.34385288
4mitotic metaphase plate congression (GO:0007080)4.34327188
5purine nucleobase biosynthetic process (GO:0009113)4.29414135
6DNA strand elongation involved in DNA replication (GO:0006271)4.27918169
7nucleobase biosynthetic process (GO:0046112)4.25970832
8DNA replication initiation (GO:0006270)4.19654735
9telomere maintenance via semi-conservative replication (GO:0032201)4.18001717
10CENP-A containing nucleosome assembly (GO:0034080)4.14142359
11establishment of integrated proviral latency (GO:0075713)4.12454904
12chromatin remodeling at centromere (GO:0031055)4.11341753
13DNA strand elongation (GO:0022616)4.09158875
14DNA unwinding involved in DNA replication (GO:0006268)4.03859312
15ribosomal large subunit biogenesis (GO:0042273)4.02536209
16transcription elongation from RNA polymerase III promoter (GO:0006385)4.02131434
17termination of RNA polymerase III transcription (GO:0006386)4.02131434
18viral transcription (GO:0019083)4.00574269
19ribosomal small subunit assembly (GO:0000028)4.00364008
20translational termination (GO:0006415)3.96857599
21protein localization to kinetochore (GO:0034501)3.96363140
22spliceosomal snRNP assembly (GO:0000387)3.85925270
23metaphase plate congression (GO:0051310)3.82710783
24ribonucleoprotein complex biogenesis (GO:0022613)3.81478944
25kinetochore organization (GO:0051383)3.80012166
26proteasome assembly (GO:0043248)3.79851571
27DNA replication-independent nucleosome organization (GO:0034724)3.79368127
28DNA replication-independent nucleosome assembly (GO:0006336)3.79368127
29formation of translation preinitiation complex (GO:0001731)3.77647972
30spliceosomal complex assembly (GO:0000245)3.72449098
31mitotic recombination (GO:0006312)3.71216776
32telomere maintenance via recombination (GO:0000722)3.67193697
33rRNA processing (GO:0006364)3.64834324
34negative regulation of DNA recombination (GO:0045910)3.59186407
35translational initiation (GO:0006413)3.59060653
36negative regulation of DNA-dependent DNA replication (GO:2000104)3.57777939
37kinetochore assembly (GO:0051382)3.57361940
38DNA replication-dependent nucleosome assembly (GO:0006335)3.55583781
39DNA replication-dependent nucleosome organization (GO:0034723)3.55583781
40ribosome biogenesis (GO:0042254)3.55206478
41establishment of protein localization to mitochondrial membrane (GO:0090151)3.53157387
42cullin deneddylation (GO:0010388)3.52487529
43translational elongation (GO:0006414)3.52434431
44rRNA metabolic process (GO:0016072)3.51447695
45telomere maintenance via telomere lengthening (GO:0010833)3.50820008
46attachment of spindle microtubules to kinetochore (GO:0008608)3.49177245
477-methylguanosine mRNA capping (GO:0006370)3.47961731
48mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.47763504
49transcription elongation from RNA polymerase I promoter (GO:0006362)3.46829819
50RNA capping (GO:0036260)3.45993399
517-methylguanosine RNA capping (GO:0009452)3.45993399
52deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.45779948
53DNA deamination (GO:0045006)3.43702319
54histone exchange (GO:0043486)3.43374321
55protein deneddylation (GO:0000338)3.43120439
56transcription-coupled nucleotide-excision repair (GO:0006283)3.39813938
57SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.39378688
58protein localization to chromosome, centromeric region (GO:0071459)3.38619708
59regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.36895839
60regulation of mitotic spindle checkpoint (GO:1903504)3.36895839
61cotranslational protein targeting to membrane (GO:0006613)3.36892658
62nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.35782172
63ribosome assembly (GO:0042255)3.33175569
64rRNA modification (GO:0000154)3.32919844
65protein targeting to ER (GO:0045047)3.31356829
66nucleotide-excision repair, DNA gap filling (GO:0006297)3.30416581
67anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.30170703
68negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.30097929
69termination of RNA polymerase I transcription (GO:0006363)3.29600649
70replication fork processing (GO:0031297)3.25190770
71establishment of chromosome localization (GO:0051303)3.25181767
72regulation of nuclear cell cycle DNA replication (GO:0033262)3.24592299
73regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.23727294
74regulation of helicase activity (GO:0051095)3.23475779
75regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.22661447
76positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.21740109
77maturation of 5.8S rRNA (GO:0000460)3.20398010
78cellular component biogenesis (GO:0044085)3.18889960
79regulation of spindle organization (GO:0090224)3.18151950
80cellular protein complex disassembly (GO:0043624)3.17904713
81deoxyribonucleotide biosynthetic process (GO:0009263)3.16652117
82pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.15634589
83DNA ligation (GO:0006266)3.14399238
84establishment of protein localization to endoplasmic reticulum (GO:0072599)3.13351472
85protein localization to endoplasmic reticulum (GO:0070972)3.12938232
86mitotic chromosome condensation (GO:0007076)3.12761608
87mitotic nuclear envelope disassembly (GO:0007077)3.12523098
88regulation of centriole replication (GO:0046599)3.10831117
89establishment of viral latency (GO:0019043)3.10326767
90resolution of meiotic recombination intermediates (GO:0000712)3.10188659
91exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.08276033
92spindle checkpoint (GO:0031577)3.08175733
93translation (GO:0006412)3.07967069
94negative regulation of mitotic sister chromatid separation (GO:2000816)3.06694567
95negative regulation of sister chromatid segregation (GO:0033046)3.06694567
96negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.06694567
97negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.06694567
98negative regulation of mitotic sister chromatid segregation (GO:0033048)3.06694567
99DNA-templated transcription, termination (GO:0006353)3.06547524
100somatic hypermutation of immunoglobulin genes (GO:0016446)3.06170316
101somatic diversification of immune receptors via somatic mutation (GO:0002566)3.06170316
102viral life cycle (GO:0019058)3.05114831
103mitotic sister chromatid segregation (GO:0000070)3.03945991
104regulation of double-strand break repair via homologous recombination (GO:0010569)3.03649646
105nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.03232500
106chaperone-mediated protein transport (GO:0072321)3.02826753
107G1/S transition of mitotic cell cycle (GO:0000082)3.02702365
108cell cycle G1/S phase transition (GO:0044843)3.02702365
109viral mRNA export from host cell nucleus (GO:0046784)3.02286589
110mitotic spindle checkpoint (GO:0071174)3.00964876
111RNA splicing, via transesterification reactions (GO:0000375)2.99839900
112presynaptic membrane assembly (GO:0097105)2.97905774
113DNA double-strand break processing (GO:0000729)2.97022805
114negative regulation of chromosome segregation (GO:0051985)2.96877623
115RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.96587412
116mRNA splicing, via spliceosome (GO:0000398)2.96587412
117transcription from RNA polymerase I promoter (GO:0006360)2.95782346
118centriole replication (GO:0007099)2.88218839
119sister chromatid segregation (GO:0000819)2.87185054
120regulation of mitotic metaphase/anaphase transition (GO:0030071)2.85695170
121regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.85695170
122regulation of sister chromatid segregation (GO:0033045)2.85574314
123regulation of mitotic sister chromatid separation (GO:0010965)2.85574314
124regulation of mitotic sister chromatid segregation (GO:0033047)2.85574314
125maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.84982508
126mitotic G2/M transition checkpoint (GO:0044818)2.84895013
127regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.84833714
128postreplication repair (GO:0006301)2.82685329
129protein neddylation (GO:0045116)2.82483701
130mitotic spindle assembly checkpoint (GO:0007094)2.81552242
131otic vesicle formation (GO:0030916)2.79473064
132intra-S DNA damage checkpoint (GO:0031573)2.79452402
133response to nitrosative stress (GO:0051409)2.79180528
134spindle assembly checkpoint (GO:0071173)2.77672188
135regulation of DNA endoreduplication (GO:0032875)2.77504995
136ATP synthesis coupled proton transport (GO:0015986)2.75491411
137energy coupled proton transport, down electrochemical gradient (GO:0015985)2.75491411
138regulation of chromosome segregation (GO:0051983)2.71782028
139DNA damage response, detection of DNA damage (GO:0042769)2.71340828
140histone H2A acetylation (GO:0043968)2.69241929
141ATP-dependent chromatin remodeling (GO:0043044)2.68910245
142telomere maintenance via telomerase (GO:0007004)2.66824198
143organelle disassembly (GO:1903008)2.61717464
144somite development (GO:0061053)2.60377319
145histone mRNA metabolic process (GO:0008334)2.59147585
146nonmotile primary cilium assembly (GO:0035058)2.56826221
147double-strand break repair via nonhomologous end joining (GO:0006303)2.56795609
148non-recombinational repair (GO:0000726)2.56795609
149regulation of meiosis I (GO:0060631)2.54695004
150recombinational repair (GO:0000725)2.54155187
151microtubule depolymerization (GO:0007019)2.54001844
152DNA catabolic process, exonucleolytic (GO:0000738)2.52073179
153somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.51882932
154isotype switching (GO:0045190)2.51882932
155somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.51882932
156synapsis (GO:0007129)2.51788763
157negative regulation of mitosis (GO:0045839)2.51065494
158termination of RNA polymerase II transcription (GO:0006369)2.50630603
159presynaptic membrane organization (GO:0097090)2.50365936
160L-serine metabolic process (GO:0006563)2.49190488
161double-strand break repair via homologous recombination (GO:0000724)2.48649108

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.86078389
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.47039730
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.15566986
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.94635740
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.94589110
6* FOXM1_23109430_ChIP-Seq_U2OS_Human3.83956874
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.61347231
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.51552213
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.23694834
10MYC_19079543_ChIP-ChIP_MESCs_Mouse3.17556030
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.16388404
12ETS1_20019798_ChIP-Seq_JURKAT_Human3.13639173
13* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.13051573
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.96893533
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.96418336
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.91716589
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.84997975
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.83662003
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.82399845
20VDR_23849224_ChIP-Seq_CD4+_Human2.49973414
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.45226825
22HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.43530654
23* XRN2_22483619_ChIP-Seq_HELA_Human2.39851767
24* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.38829229
25* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.38720332
26MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.24860774
27FOXP3_21729870_ChIP-Seq_TREG_Human2.24663740
28RBPJ_22232070_ChIP-Seq_NCS_Mouse2.21438156
29ELF1_17652178_ChIP-ChIP_JURKAT_Human2.19073724
30TAF15_26573619_Chip-Seq_HEK293_Human2.17329081
31AR_21909140_ChIP-Seq_LNCAP_Human2.16209597
32DCP1A_22483619_ChIP-Seq_HELA_Human2.13236958
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.12080929
34IGF1R_20145208_ChIP-Seq_DFB_Human2.10997765
35ZNF274_21170338_ChIP-Seq_K562_Hela2.09272977
36E2F1_18555785_ChIP-Seq_MESCs_Mouse2.08528877
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.06944396
38ELK1_19687146_ChIP-ChIP_HELA_Human2.05045239
39TTF2_22483619_ChIP-Seq_HELA_Human2.02994602
40THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00735866
41MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.99755773
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.97941539
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97060885
44* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.94282070
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.93059759
46ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.90718343
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.90491539
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89725696
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88531141
50VDR_22108803_ChIP-Seq_LS180_Human1.88273221
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.88083346
52GBX2_23144817_ChIP-Seq_PC3_Human1.82860046
53P300_19829295_ChIP-Seq_ESCs_Human1.81575920
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81127310
55GABP_19822575_ChIP-Seq_HepG2_Human1.80543666
56FLI1_27457419_Chip-Seq_LIVER_Mouse1.74627059
57NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.71626714
58NANOG_18555785_ChIP-Seq_MESCs_Mouse1.70665092
59YY1_21170310_ChIP-Seq_MESCs_Mouse1.66673720
60PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.65250926
61FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.63505241
62CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61548254
63CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57506762
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.57022828
65CTBP1_25329375_ChIP-Seq_LNCAP_Human1.54138323
66NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.51304802
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.50956928
68TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.48769892
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43254257
70HOXB4_20404135_ChIP-ChIP_EML_Mouse1.42670525
71MYC_18940864_ChIP-ChIP_HL60_Human1.41990899
72* SRF_21415370_ChIP-Seq_HL-1_Mouse1.41523006
73* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39662119
74TP63_19390658_ChIP-ChIP_HaCaT_Human1.38870049
75SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36482424
76PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36247094
77CIITA_25753668_ChIP-Seq_RAJI_Human1.31232223
78PIAS1_25552417_ChIP-Seq_VCAP_Human1.30280993
79MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28489099
80KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25026462
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22870841
82KDM5A_27292631_Chip-Seq_BREAST_Human1.21196364
83MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20724695
84SOX2_18555785_ChIP-Seq_MESCs_Mouse1.20471424
85IRF1_19129219_ChIP-ChIP_H3396_Human1.19696603
86AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.18962839
87RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.18615109
88ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.15966769
89TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.15854024
90TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15751870
91NOTCH1_21737748_ChIP-Seq_TLL_Human1.14675939
92RNF2_27304074_Chip-Seq_NSC_Mouse1.13828224
93ER_23166858_ChIP-Seq_MCF-7_Human1.12418197
94* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.10847264
95OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10846459
96FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.10099181
97* EZH2_27294783_Chip-Seq_NPCs_Mouse1.07204610
98ELK1_22589737_ChIP-Seq_MCF10A_Human1.05751995
99CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.03730501
100SMAD4_21799915_ChIP-Seq_A2780_Human1.03080648
101CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.02590871
102CBX2_27304074_Chip-Seq_ESCs_Mouse1.01641544
103BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01286733
104SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.01161969
105ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01002588
106SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.99738933
107SALL1_21062744_ChIP-ChIP_HESCs_Human0.99325490
108SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.98638217
109GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98325024
110SMAD3_21741376_ChIP-Seq_EPCs_Human0.97788787
111* IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97600814
112* CBP_20019798_ChIP-Seq_JUKART_Human0.97600814
113* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97268472
114POU5F1_16153702_ChIP-ChIP_HESCs_Human0.96862136
115HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96452379
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96364157
117SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95280871
118POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.95267195
119TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95267195
120FUS_26573619_Chip-Seq_HEK293_Human0.93980986
121NANOG_18555785_Chip-Seq_ESCs_Mouse0.93649614
122SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93643893
123KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.93475865
124SOX9_26525672_Chip-Seq_HEART_Mouse0.93454994
125AR_25329375_ChIP-Seq_VCAP_Human0.92815681
126PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.92476500
127SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.92008994
128NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.90783572
129ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.90755881
130CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89590557
131SOX2_16153702_ChIP-ChIP_HESCs_Human0.88305774
132POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.88006395
133CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86615442
134* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.85434967
135FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.84634783
136NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.82842426
137* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.81395096
138EWS_26573619_Chip-Seq_HEK293_Human0.79419619
139CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.79116113
140NANOG_16153702_ChIP-ChIP_HESCs_Human0.77974700
141NANOG_21062744_ChIP-ChIP_HESCs_Human0.76631025
142TCF3_18692474_ChIP-Seq_MEFs_Mouse0.76455881
143SOX17_20123909_ChIP-Seq_XEN_Mouse0.75093803
144STAT3_1855785_ChIP-Seq_MESCs_Mouse0.74742998
145DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.73860792
146TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.73562905
147GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.72871694
148KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.72595553
149KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.72595553

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.93539663
2MP0008057_abnormal_DNA_replication4.76298298
3MP0010094_abnormal_chromosome_stability4.44963147
4MP0004957_abnormal_blastocyst_morpholog4.31028674
5MP0003111_abnormal_nucleus_morphology4.04548966
6MP0003077_abnormal_cell_cycle3.65723426
7MP0008058_abnormal_DNA_repair3.57864003
8MP0006292_abnormal_olfactory_placode3.34569144
9MP0003123_paternal_imprinting2.85580448
10MP0001529_abnormal_vocalization2.83587734
11MP0008877_abnormal_DNA_methylation2.54035129
12MP0008932_abnormal_embryonic_tissue2.44359330
13MP0003806_abnormal_nucleotide_metabolis2.44087577
14MP0003718_maternal_effect2.40638081
15MP0008007_abnormal_cellular_replicative2.38325938
16MP0003880_abnormal_central_pattern2.08296576
17MP0009379_abnormal_foot_pigmentation2.04299363
18MP0003121_genomic_imprinting1.93883819
19MP0003786_premature_aging1.86079744
20MP0002102_abnormal_ear_morphology1.84245740
21MP0000350_abnormal_cell_proliferation1.82626623
22MP0001730_embryonic_growth_arrest1.80328902
23MP0003315_abnormal_perineum_morphology1.57427619
24MP0002736_abnormal_nociception_after1.54832530
25MP0004147_increased_porphyrin_level1.53996485
26MP0003890_abnormal_embryonic-extraembry1.53567353
27MP0000566_synostosis1.52127670
28MP0003119_abnormal_digestive_system1.49063652
29MP0001984_abnormal_olfaction1.47418232
30MP0008789_abnormal_olfactory_epithelium1.46571152
31MP0001697_abnormal_embryo_size1.43293644
32MP0003136_yellow_coat_color1.37047182
33MP0010030_abnormal_orbit_morphology1.31841235
34MP0005380_embryogenesis_phenotype1.30003066
35MP0001672_abnormal_embryogenesis/_devel1.30003066
36MP0003938_abnormal_ear_development1.29440553
37MP0002080_prenatal_lethality1.28217334
38MP0002396_abnormal_hematopoietic_system1.27658009
39MP0002085_abnormal_embryonic_tissue1.27523408
40MP0002751_abnormal_autonomic_nervous1.22873452
41MP0003787_abnormal_imprinting1.22868689
42MP0001188_hyperpigmentation1.22090169
43MP0005499_abnormal_olfactory_system1.21027435
44MP0005394_taste/olfaction_phenotype1.21027435
45MP0002697_abnormal_eye_size1.20949230
46MP0002210_abnormal_sex_determination1.19666882
47MP0002132_abnormal_respiratory_system1.19398120
48MP0001764_abnormal_homeostasis1.18813399
49MP0002938_white_spotting1.18038724
50MP0004215_abnormal_myocardial_fiber1.15858181
51MP0003567_abnormal_fetal_cardiomyocyte1.14582948
52MP0000647_abnormal_sebaceous_gland1.13748222
53MP0001486_abnormal_startle_reflex1.12666099
54MP0001177_atelectasis1.11898093
55MP0002234_abnormal_pharynx_morphology1.10105657
56MP0001293_anophthalmia1.08986684
57MP0001145_abnormal_male_reproductive1.08609548
58MP0005253_abnormal_eye_physiology1.08351658
59MP0002084_abnormal_developmental_patter1.07343213
60MP0004885_abnormal_endolymph1.05327330
61MP0005423_abnormal_somatic_nervous1.04006221
62MP0006072_abnormal_retinal_apoptosis1.03189182
63MP0001968_abnormal_touch/_nociception1.02901851
64MP0005187_abnormal_penis_morphology1.01840169
65MP0000313_abnormal_cell_death1.01037889
66MP0002638_abnormal_pupillary_reflex1.00695694
67MP0001286_abnormal_eye_development1.00340395
68MP0001905_abnormal_dopamine_level1.00205162
69MP0000653_abnormal_sex_gland1.00175787
70MP0003646_muscle_fatigue0.99436587
71MP0008995_early_reproductive_senescence0.99299979
72MP0003984_embryonic_growth_retardation0.99113046
73MP0005248_abnormal_Harderian_gland0.98746819
74MP0001929_abnormal_gametogenesis0.98439887
75MP0002088_abnormal_embryonic_growth/wei0.98361155
76MP0003941_abnormal_skin_development0.98150319
77MP0002272_abnormal_nervous_system0.96581441
78MP0003937_abnormal_limbs/digits/tail_de0.96202358
79MP0003122_maternal_imprinting0.96144864
80MP0004197_abnormal_fetal_growth/weight/0.95432174
81MP0002086_abnormal_extraembryonic_tissu0.94784041
82MP0004742_abnormal_vestibular_system0.93955320
83MP0004145_abnormal_muscle_electrophysio0.92583106
84MP0006035_abnormal_mitochondrial_morpho0.92499700
85MP0009697_abnormal_copulation0.92168337
86MP0006036_abnormal_mitochondrial_physio0.92005341
87MP0002734_abnormal_mechanical_nocicepti0.91677959
88MP0009250_abnormal_appendicular_skeleto0.91616720
89MP0005391_vision/eye_phenotype0.90644547
90MP0005551_abnormal_eye_electrophysiolog0.90639853
91MP0003221_abnormal_cardiomyocyte_apopto0.90411046
92MP0005389_reproductive_system_phenotype0.90379448
93MP0002160_abnormal_reproductive_system0.90107921
94MP0000383_abnormal_hair_follicle0.88262847
95MP0004381_abnormal_hair_follicle0.88087130
96MP0002019_abnormal_tumor_incidence0.87880007
97MP0002735_abnormal_chemical_nociception0.87670256
98MP0004142_abnormal_muscle_tone0.87544166
99MP0001299_abnormal_eye_distance/0.87180376
100MP0003763_abnormal_thymus_physiology0.87039288
101MP0009745_abnormal_behavioral_response0.84361768
102MP0000703_abnormal_thymus_morphology0.84036302
103MP0003861_abnormal_nervous_system0.84017899
104MP0000537_abnormal_urethra_morphology0.83475536
105MP0002653_abnormal_ependyma_morphology0.82400844
106MP0002067_abnormal_sensory_capabilities0.82368660
107MP0002184_abnormal_innervation0.81967772
108MP0003011_delayed_dark_adaptation0.81531338
109MP0002111_abnormal_tail_morphology0.81335812
110MP0002822_catalepsy0.81230372
111MP0004133_heterotaxia0.80420906
112MP0001919_abnormal_reproductive_system0.80186750
113MP0000579_abnormal_nail_morphology0.79964004
114MP0009046_muscle_twitch0.79948291
115MP0006276_abnormal_autonomic_nervous0.79209461
116MP0001119_abnormal_female_reproductive0.78517256
117MP0000049_abnormal_middle_ear0.76747703
118MP0002163_abnormal_gland_morphology0.74302025
119MP0000490_abnormal_crypts_of0.74248688
120MP0001485_abnormal_pinna_reflex0.72766081
121MP0002837_dystrophic_cardiac_calcinosis0.71615795
122MP0009672_abnormal_birth_weight0.71520855
123MP0009053_abnormal_anal_canal0.71163544
124MP0005266_abnormal_metabolism0.69970935
125MP0009333_abnormal_splenocyte_physiolog0.66344621
126MP0005409_darkened_coat_color0.66039705
127MP0003755_abnormal_palate_morphology0.61759577
128MP0003698_abnormal_male_reproductive0.60877944
129MP0005379_endocrine/exocrine_gland_phen0.59924433
130MP0009703_decreased_birth_body0.59148934
131MP0005220_abnormal_exocrine_pancreas0.58927654
132MP0005075_abnormal_melanosome_morpholog0.58296565
133MP0003186_abnormal_redox_activity0.56777050
134MP0002127_abnormal_cardiovascular_syste0.56087118
135MP0000631_abnormal_neuroendocrine_gland0.55748706
136MP0002233_abnormal_nose_morphology0.55458976
137MP0000778_abnormal_nervous_system0.55089238

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.22536275
2Reticulocytopenia (HP:0001896)4.06903540
3Breast hypoplasia (HP:0003187)3.93689017
4Abnormality of cells of the erythroid lineage (HP:0012130)3.82142644
5Abnormal number of erythroid precursors (HP:0012131)3.40020581
6Patellar aplasia (HP:0006443)3.34058950
7Macrocytic anemia (HP:0001972)3.30880654
8Oral leukoplakia (HP:0002745)3.24522723
9Volvulus (HP:0002580)3.17123805
10Aplasia/Hypoplasia of the patella (HP:0006498)3.15426325
11Chromsome breakage (HP:0040012)3.07231497
12Abnormality of the labia minora (HP:0012880)3.04542837
13Cerebral hypomyelination (HP:0006808)3.03266006
14Colon cancer (HP:0003003)2.98676403
15Septo-optic dysplasia (HP:0100842)2.98178469
16Chromosomal breakage induced by crosslinking agents (HP:0003221)2.95791738
17Acute necrotizing encephalopathy (HP:0006965)2.89195633
18Absent radius (HP:0003974)2.86805656
19Horseshoe kidney (HP:0000085)2.84578786
20Abnormality of the preputium (HP:0100587)2.79284432
21Aplasia involving forearm bones (HP:0009822)2.72819328
22Absent forearm bone (HP:0003953)2.72819328
23Increased hepatocellular lipid droplets (HP:0006565)2.72042031
24Impulsivity (HP:0100710)2.60304369
25Carpal bone hypoplasia (HP:0001498)2.59690281
26Facial hemangioma (HP:0000329)2.57658201
27Ependymoma (HP:0002888)2.54723657
28Mitochondrial inheritance (HP:0001427)2.51904045
29Pallor (HP:0000980)2.49740220
30Medulloblastoma (HP:0002885)2.47326942
31Abnormal mitochondria in muscle tissue (HP:0008316)2.47137531
32Meckel diverticulum (HP:0002245)2.46331744
33Delusions (HP:0000746)2.45707379
34Agnosia (HP:0010524)2.45255040
35True hermaphroditism (HP:0010459)2.43882092
36Abnormality of chromosome stability (HP:0003220)2.43059254
37Abnormal lung lobation (HP:0002101)2.41298763
38Abnormality of the ileum (HP:0001549)2.41124423
39Pancreatic cysts (HP:0001737)2.39532856
40Increased CSF lactate (HP:0002490)2.38096675
41Absent thumb (HP:0009777)2.36590451
42Degeneration of anterior horn cells (HP:0002398)2.36119620
43Abnormality of the anterior horn cell (HP:0006802)2.36119620
44Gait imbalance (HP:0002141)2.33606842
45Supernumerary spleens (HP:0009799)2.32594556
46Medial flaring of the eyebrow (HP:0010747)2.32343609
47Abnormality of glycolysis (HP:0004366)2.31749495
48Increased serum pyruvate (HP:0003542)2.31749495
49Hyperglycinemia (HP:0002154)2.30111790
50Congenital primary aphakia (HP:0007707)2.28469144
51Acute encephalopathy (HP:0006846)2.28294090
52Pancreatic fibrosis (HP:0100732)2.27640608
53Progressive macrocephaly (HP:0004481)2.26174403
54Absent septum pellucidum (HP:0001331)2.25203754
55Rough bone trabeculation (HP:0100670)2.24467093
56Genital tract atresia (HP:0001827)2.23934248
57Aplastic anemia (HP:0001915)2.23729916
58Lipid accumulation in hepatocytes (HP:0006561)2.23211437
59Molar tooth sign on MRI (HP:0002419)2.23002494
60Abnormality of midbrain morphology (HP:0002418)2.23002494
61Optic nerve hypoplasia (HP:0000609)2.19487559
623-Methylglutaconic aciduria (HP:0003535)2.19218956
63Triphalangeal thumb (HP:0001199)2.18574547
64Nephroblastoma (Wilms tumor) (HP:0002667)2.18245517
65Aplasia/Hypoplasia of the uvula (HP:0010293)2.17802162
66Microretrognathia (HP:0000308)2.17781368
67Premature graying of hair (HP:0002216)2.17033463
68Cellular immunodeficiency (HP:0005374)2.16644536
69Vaginal atresia (HP:0000148)2.15512146
70Embryonal renal neoplasm (HP:0011794)2.15482489
71Abnormality of the septum pellucidum (HP:0007375)2.13395517
72Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.12969633
73Neoplasm of the pancreas (HP:0002894)2.08293913
74Nephrogenic diabetes insipidus (HP:0009806)2.07771325
7511 pairs of ribs (HP:0000878)2.07458122
76Secondary amenorrhea (HP:0000869)2.06554995
77Stenosis of the external auditory canal (HP:0000402)2.06483947
78Methylmalonic acidemia (HP:0002912)2.06191165
79Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.05437426
80Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.05171212
81Atresia of the external auditory canal (HP:0000413)2.04058634
82Increased serum lactate (HP:0002151)2.03792989
83Nephronophthisis (HP:0000090)2.02310470
84Small intestinal stenosis (HP:0012848)2.01360678
85Duodenal stenosis (HP:0100867)2.01360678
86Glioma (HP:0009733)2.01197023
87Rhabdomyosarcoma (HP:0002859)2.00040270
88Abnormal number of incisors (HP:0011064)1.99294978
89Neoplasm of the colon (HP:0100273)1.97170635
90Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.97106644
91Abnormality of the heme biosynthetic pathway (HP:0010472)1.96255864
92Abnormality of the duodenum (HP:0002246)1.95256332
93Cleft eyelid (HP:0000625)1.93296477
94Abnormality of serum amino acid levels (HP:0003112)1.92252254
95Respiratory difficulties (HP:0002880)1.91645780
96Hepatocellular necrosis (HP:0001404)1.91106046
97Intestinal atresia (HP:0011100)1.90680559
98Bone marrow hypocellularity (HP:0005528)1.89231673
99Biliary tract neoplasm (HP:0100574)1.88423432
100Aplasia/Hypoplasia of the earlobes (HP:0009906)1.86279547
101Shoulder girdle muscle weakness (HP:0003547)1.85273671
102CNS hypomyelination (HP:0003429)1.84615395
103Proximal placement of thumb (HP:0009623)1.83438204
104Hypoplasia of the capital femoral epiphysis (HP:0003090)1.82409225
105Microvesicular hepatic steatosis (HP:0001414)1.82328498
106Hypoplasia of the radius (HP:0002984)1.81631251
107Aplasia/Hypoplasia of the sternum (HP:0006714)1.81234552
108Exertional dyspnea (HP:0002875)1.80387084
109Cortical dysplasia (HP:0002539)1.79834425
110Hypobetalipoproteinemia (HP:0003563)1.78993338
111Sloping forehead (HP:0000340)1.78671086
112Neoplasm of the oral cavity (HP:0100649)1.78521228
113Capillary hemangiomas (HP:0005306)1.77662640
114Short tibia (HP:0005736)1.76841934
115Irregular epiphyses (HP:0010582)1.76424872
116Megaloblastic anemia (HP:0001889)1.75997533
117Aplasia/Hypoplasia of the tongue (HP:0010295)1.75235040
118Myelodysplasia (HP:0002863)1.74842764
119Renal Fanconi syndrome (HP:0001994)1.74673076
120Aplasia/Hypoplasia of the tibia (HP:0005772)1.73959073
121Limb dystonia (HP:0002451)1.73904164
122Abnormality of glycine metabolism (HP:0010895)1.73659806
123Abnormality of serine family amino acid metabolism (HP:0010894)1.73659806
124Selective tooth agenesis (HP:0001592)1.73452820
125Oligodactyly (hands) (HP:0001180)1.73178837
126Postaxial hand polydactyly (HP:0001162)1.73078146
127Abnormality of pyrimidine metabolism (HP:0004353)1.73064299
128Hyperglycinuria (HP:0003108)1.72919233
129Atrophy/Degeneration involving motor neurons (HP:0007373)1.72143511
130Gonadotropin excess (HP:0000837)1.71951206
131Duplicated collecting system (HP:0000081)1.71782095
132Cerebral edema (HP:0002181)1.70544511
133Bifid tongue (HP:0010297)1.70292831
134Unsteady gait (HP:0002317)1.69205768
135Premature ovarian failure (HP:0008209)1.67739304
136Abnormality of the carotid arteries (HP:0005344)1.67482814
137Pancytopenia (HP:0001876)1.64915460
138Poor coordination (HP:0002370)1.64642840
139Gastrointestinal atresia (HP:0002589)1.63818721
140Congenital, generalized hypertrichosis (HP:0004540)1.62445615
141Broad foot (HP:0001769)1.61740971
142Sclerocornea (HP:0000647)1.60646305
143Specific learning disability (HP:0001328)1.60379661
144Ectopic kidney (HP:0000086)1.60151230
145Leukodystrophy (HP:0002415)1.58657064
146Postaxial foot polydactyly (HP:0001830)1.57999746
147Maternal diabetes (HP:0009800)1.57566290
148Cerebellar dysplasia (HP:0007033)1.56990883
149Small hand (HP:0200055)1.53994652
150Abnormality of the renal medulla (HP:0100957)1.53374018
151Abnormality of the astrocytes (HP:0100707)1.53045815
152Astrocytoma (HP:0009592)1.53045815
153Median cleft lip (HP:0000161)1.52224647

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.60480838
2WEE14.48180215
3CDC74.28052251
4STK163.19839785
5SRPK13.06761319
6EIF2AK12.96232865
7VRK12.71502598
8TSSK62.49270773
9TNIK2.31996629
10MKNK12.26937832
11MKNK22.20489500
12VRK22.19054492
13PLK32.18054352
14PNCK2.18026093
15DYRK32.06254263
16PLK42.05997223
17EIF2AK32.04509957
18NME22.03185737
19CCNB11.99854409
20TAF11.98786688
21ACVR1B1.91113018
22BRSK21.88390371
23NEK21.87828528
24PLK11.87333015
25TLK11.84123688
26TRIM281.83598042
27PASK1.79564521
28MAP3K41.78444716
29TTK1.72261566
30EPHA41.47426557
31AURKB1.41452227
32NME11.33006989
33BRSK11.31368339
34ATR1.27017619
35MST41.21179680
36AURKA1.21171554
37CDK71.16312322
38AKT31.14553976
39CHEK21.12671132
40MAP4K21.10421857
41PLK21.09138993
42CHEK11.04923377
43MAP2K71.00834360
44STK38L0.98563310
45NEK10.95726881
46CDK40.89870026
47CDK80.87312971
48EIF2AK20.86559848
49FRK0.86437341
50CSNK1G20.85092158
51CSNK2A20.82896843
52DYRK20.81951519
53OXSR10.80945768
54MARK10.80235823
55OBSCN0.79454402
56BMPR20.79412143
57PINK10.77033632
58CSNK2A10.76234567
59ZAK0.75963717
60RPS6KA40.74621748
61NUAK10.74068376
62GRK60.73522096
63LATS10.72988497
64PBK0.72613977
65CASK0.72193680
66BRAF0.71978155
67MINK10.71452018
68ATM0.70625010
69CDK20.67696250
70STK390.66971894
71MAP3K80.65998831
72TESK20.64858008
73WNK30.64119738
74STK30.63123512
75YES10.62803274
76CDK10.61580872
77DYRK1A0.58686411
78KSR10.58658954
79MELK0.57322955
80RPS6KB20.56598247
81PRKCI0.56211795
82MAP3K120.55577903
83CSNK1G30.54683364
84CSNK1A1L0.54423325
85WNK40.54116181
86ADRBK20.53860677
87CDK30.53121733
88UHMK10.52977084
89CLK10.52291245
90PRKCE0.51802510
91DAPK10.51781251
92NTRK30.51245159
93FGFR20.51022421
94RAF10.50605305
95CDK190.50482334
96TGFBR10.50391300
97FGR0.49594689
98PAK30.48749712
99BCR0.48338275
100CSNK1E0.47856903
101INSRR0.47093555
102FGFR10.44671940
103STK40.44308370
104TEC0.44172918
105CDK180.42348143
106GRK10.41653079
107STK100.41302497
108ERBB30.41249081
109CDK11A0.39964418
110PRKCG0.39951154
111MAPK130.39785017
112NLK0.39515483
113RPS6KA50.39387392
114BMPR1B0.38698395
115CDK150.38641842
116TAOK20.37801317
117CDK140.36546637
118ALK0.35780249
119MAPK150.34792991
120EPHB20.34625938
121BCKDK0.34353578
122BRD40.34028455
123PAK10.33727769
124PRKDC0.31363830
125CAMK2A0.28831907
126CSNK1G10.28780806
127DMPK0.28450398
128PDK20.27532282
129CAMK2B0.27245192
130TAOK30.26368145
131EPHA20.25970254
132STK240.24673249
133CDK60.23327605
134GRK70.23312822

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.46969817
2Mismatch repair_Homo sapiens_hsa034304.35928796
3Ribosome_Homo sapiens_hsa030104.16672278
4RNA polymerase_Homo sapiens_hsa030204.04116522
5Proteasome_Homo sapiens_hsa030503.78988858
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.78817110
7Spliceosome_Homo sapiens_hsa030403.66201084
8Homologous recombination_Homo sapiens_hsa034403.18621311
9RNA transport_Homo sapiens_hsa030133.07796165
10Nucleotide excision repair_Homo sapiens_hsa034202.78170821
11Pyrimidine metabolism_Homo sapiens_hsa002402.73007810
12Base excision repair_Homo sapiens_hsa034102.70564852
13Cell cycle_Homo sapiens_hsa041102.37776047
14Basal transcription factors_Homo sapiens_hsa030222.28647529
15Fanconi anemia pathway_Homo sapiens_hsa034602.24668291
16Non-homologous end-joining_Homo sapiens_hsa034502.13738766
17One carbon pool by folate_Homo sapiens_hsa006702.10296865
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.04915216
19RNA degradation_Homo sapiens_hsa030182.04046352
20Propanoate metabolism_Homo sapiens_hsa006402.00699731
21mRNA surveillance pathway_Homo sapiens_hsa030151.68882239
22Purine metabolism_Homo sapiens_hsa002301.57131389
23Oxidative phosphorylation_Homo sapiens_hsa001901.52845289
24Parkinsons disease_Homo sapiens_hsa050121.48730065
25Huntingtons disease_Homo sapiens_hsa050161.36808783
26Vitamin B6 metabolism_Homo sapiens_hsa007501.35735241
27Protein export_Homo sapiens_hsa030601.35626159
28Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.35475573
29Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21112600
30Oocyte meiosis_Homo sapiens_hsa041141.19633362
31p53 signaling pathway_Homo sapiens_hsa041151.19034125
32Drug metabolism - other enzymes_Homo sapiens_hsa009831.14648058
33Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.12670515
34Systemic lupus erythematosus_Homo sapiens_hsa053221.10695187
35Epstein-Barr virus infection_Homo sapiens_hsa051690.99890720
36Butanoate metabolism_Homo sapiens_hsa006500.97536878
37Alzheimers disease_Homo sapiens_hsa050100.93856675
38Folate biosynthesis_Homo sapiens_hsa007900.90652784
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.89962551
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.89397922
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87445763
42Cysteine and methionine metabolism_Homo sapiens_hsa002700.85707066
43Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82950923
44Cyanoamino acid metabolism_Homo sapiens_hsa004600.72530522
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.72090181
46GABAergic synapse_Homo sapiens_hsa047270.71124589
47Selenocompound metabolism_Homo sapiens_hsa004500.70555363
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68519019
49Nicotine addiction_Homo sapiens_hsa050330.65459558
50Nitrogen metabolism_Homo sapiens_hsa009100.64265532
51Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63413975
52Alcoholism_Homo sapiens_hsa050340.63065224
53Peroxisome_Homo sapiens_hsa041460.60823045
54beta-Alanine metabolism_Homo sapiens_hsa004100.60234041
55Tryptophan metabolism_Homo sapiens_hsa003800.58701461
56Biosynthesis of amino acids_Homo sapiens_hsa012300.57238797
572-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.57154306
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.56127314
59Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55844709
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54520011
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.53147708
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.50732404
63Pentose and glucuronate interconversions_Homo sapiens_hsa000400.50283170
64Primary immunodeficiency_Homo sapiens_hsa053400.50270048
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.49590875
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49535242
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47313645
68Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.47306070
69Caffeine metabolism_Homo sapiens_hsa002320.47009992
70Glutamatergic synapse_Homo sapiens_hsa047240.46776196
71Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.46040743
72Metabolic pathways_Homo sapiens_hsa011000.44996540
73Fatty acid degradation_Homo sapiens_hsa000710.43695707
74Viral carcinogenesis_Homo sapiens_hsa052030.42914705
75Olfactory transduction_Homo sapiens_hsa047400.41451493
76Sulfur relay system_Homo sapiens_hsa041220.40797977
77Regulation of autophagy_Homo sapiens_hsa041400.40280374
78Amphetamine addiction_Homo sapiens_hsa050310.37973119
79Glutathione metabolism_Homo sapiens_hsa004800.37250320
80Chemical carcinogenesis_Homo sapiens_hsa052040.37188200
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.36822932
82Morphine addiction_Homo sapiens_hsa050320.36362806
83Fatty acid metabolism_Homo sapiens_hsa012120.35331732
84Herpes simplex infection_Homo sapiens_hsa051680.34752140
85Linoleic acid metabolism_Homo sapiens_hsa005910.34082474
86Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33077443
87Phototransduction_Homo sapiens_hsa047440.32756548
88Pentose phosphate pathway_Homo sapiens_hsa000300.31068860
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.30706076
90Tight junction_Homo sapiens_hsa045300.30609855
91Circadian entrainment_Homo sapiens_hsa047130.29923320
92Vitamin digestion and absorption_Homo sapiens_hsa049770.28422499
93Thyroid cancer_Homo sapiens_hsa052160.27853032
94Dopaminergic synapse_Homo sapiens_hsa047280.27462159
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26809812
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24961797
97* HTLV-I infection_Homo sapiens_hsa051660.24199103
98Tyrosine metabolism_Homo sapiens_hsa003500.24062245
99Type I diabetes mellitus_Homo sapiens_hsa049400.22546009
100Carbon metabolism_Homo sapiens_hsa012000.20501373
101Steroid biosynthesis_Homo sapiens_hsa001000.19471906
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.17522373
103Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16898129
104Wnt signaling pathway_Homo sapiens_hsa043100.16807013
105Long-term potentiation_Homo sapiens_hsa047200.16136813
106Basal cell carcinoma_Homo sapiens_hsa052170.15456893
107* Antigen processing and presentation_Homo sapiens_hsa046120.15352285
108Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.14355574
109MicroRNAs in cancer_Homo sapiens_hsa052060.12862710
110TGF-beta signaling pathway_Homo sapiens_hsa043500.11156155
111Pyruvate metabolism_Homo sapiens_hsa006200.09272030
112Hippo signaling pathway_Homo sapiens_hsa043900.09217930
113Cardiac muscle contraction_Homo sapiens_hsa042600.05371271
114Arginine and proline metabolism_Homo sapiens_hsa003300.04682394
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.03831060
116Fatty acid elongation_Homo sapiens_hsa000620.03449781
117Steroid hormone biosynthesis_Homo sapiens_hsa001400.02545632
118Circadian rhythm_Homo sapiens_hsa047100.02468043
119Graft-versus-host disease_Homo sapiens_hsa053320.01771703
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.01536015
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.00797122
122T cell receptor signaling pathway_Homo sapiens_hsa046600.00672184
123Hedgehog signaling pathway_Homo sapiens_hsa043400.00618761
124Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760-0.0365980
125Primary bile acid biosynthesis_Homo sapiens_hsa00120-0.0330280
126Retinol metabolism_Homo sapiens_hsa00830-0.0325201
127Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072-0.0302649
128Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650-0.0239046
129Serotonergic synapse_Homo sapiens_hsa04726-0.0190969
130Colorectal cancer_Homo sapiens_hsa05210-0.0163518
131Taste transduction_Homo sapiens_hsa04742-0.0145460

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