NFYC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)5.06422883
2modulation by symbiont of host defense response (GO:0052031)5.06422883
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.06422883
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.06422883
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.06422883
6modulation by symbiont of host immune response (GO:0052553)5.06422883
7mitotic metaphase plate congression (GO:0007080)4.90248729
8positive regulation of gamma-delta T cell activation (GO:0046645)4.90089103
9DNA replication checkpoint (GO:0000076)4.81098461
10nucleobase biosynthetic process (GO:0046112)4.64990811
11purine nucleobase biosynthetic process (GO:0009113)4.64094878
12protein localization to kinetochore (GO:0034501)4.63206005
13neutrophil activation involved in immune response (GO:0002283)4.50005318
14DNA strand elongation involved in DNA replication (GO:0006271)4.49066119
15DNA replication initiation (GO:0006270)4.33489321
16DNA strand elongation (GO:0022616)4.32202921
17formation of translation preinitiation complex (GO:0001731)4.23793809
18metaphase plate congression (GO:0051310)4.20333415
19protein localization to chromosome, centromeric region (GO:0071459)4.05151192
20ribosome biogenesis (GO:0042254)4.02498540
21regulation of B cell receptor signaling pathway (GO:0050855)4.00190341
22DNA unwinding involved in DNA replication (GO:0006268)3.99494816
23telomere maintenance via semi-conservative replication (GO:0032201)3.98678214
24mitotic nuclear envelope disassembly (GO:0007077)3.93663044
25DNA replication-dependent nucleosome organization (GO:0034723)3.82259984
26DNA replication-dependent nucleosome assembly (GO:0006335)3.82259984
27maturation of SSU-rRNA (GO:0030490)3.82202242
28DNA deamination (GO:0045006)3.82127853
29response to peptidoglycan (GO:0032494)3.78389136
30regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.77291191
31regulation of spindle organization (GO:0090224)3.77046957
32telomere maintenance via recombination (GO:0000722)3.67311711
33negative regulation of cell killing (GO:0031342)3.65648391
34negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.65648391
35mitotic sister chromatid segregation (GO:0000070)3.63159779
36immunoglobulin mediated immune response (GO:0016064)3.62495806
37ribosome assembly (GO:0042255)3.62409945
38membrane disassembly (GO:0030397)3.60660614
39nuclear envelope disassembly (GO:0051081)3.60660614
40rRNA modification (GO:0000154)3.58552684
41establishment of chromosome localization (GO:0051303)3.56751571
42neutrophil mediated immunity (GO:0002446)3.54514687
43mitotic recombination (GO:0006312)3.53002813
44spliceosomal snRNP assembly (GO:0000387)3.52047809
45CENP-A containing nucleosome assembly (GO:0034080)3.51727696
46regulation of gamma-delta T cell activation (GO:0046643)3.49919171
47ribonucleoprotein complex biogenesis (GO:0022613)3.49335897
48respiratory burst (GO:0045730)3.47070497
49attachment of spindle microtubules to kinetochore (GO:0008608)3.46698472
50DNA replication-independent nucleosome organization (GO:0034724)3.46668388
51DNA replication-independent nucleosome assembly (GO:0006336)3.46668388
52neutrophil activation (GO:0042119)3.43911917
53anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.42894538
54chromatin remodeling at centromere (GO:0031055)3.42245697
55macrophage activation involved in immune response (GO:0002281)3.40919639
56positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.40660011
57regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.38545523
58folic acid metabolic process (GO:0046655)3.35275479
59response to host immune response (GO:0052572)3.33520011
60response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.33520011
61protein deneddylation (GO:0000338)3.30662199
62mitotic chromosome condensation (GO:0007076)3.28212301
63rRNA processing (GO:0006364)3.27775349
64detection of other organism (GO:0098543)3.27287977
65proteasome assembly (GO:0043248)3.26718815
66B cell receptor signaling pathway (GO:0050853)3.26540602
67positive regulation of chromosome segregation (GO:0051984)3.26499736
68antigen processing and presentation of endogenous antigen (GO:0019883)3.26381681
69cullin deneddylation (GO:0010388)3.25593707
70regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.25427487
71negative regulation of interleukin-12 production (GO:0032695)3.24654402
72detection of bacterium (GO:0016045)3.23841201
73antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.23678864
74regulation of mast cell degranulation (GO:0043304)3.22913079
75telomere maintenance via telomere lengthening (GO:0010833)3.22599354
76sister chromatid segregation (GO:0000819)3.22197474
77negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.20014633
78regulation of gamma-delta T cell differentiation (GO:0045586)3.19372276
79positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.18736023
80positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.18242095
81ribosomal small subunit assembly (GO:0000028)3.17455475
82rRNA metabolic process (GO:0016072)3.15882961
83folic acid-containing compound biosynthetic process (GO:0009396)3.15695100
84spindle checkpoint (GO:0031577)3.15541259
85IMP biosynthetic process (GO:0006188)3.15506755
86positive regulation of B cell differentiation (GO:0045579)3.15233501
87granulocyte activation (GO:0036230)3.14461172
88negative regulation of chromosome segregation (GO:0051985)3.12471301
89viral mRNA export from host cell nucleus (GO:0046784)3.11286624
90regulation of chromosome segregation (GO:0051983)3.10723662
91DNA damage response, detection of DNA damage (GO:0042769)3.10078521
92histone H2A acetylation (GO:0043968)3.09146055
93negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.09129525
94negative regulation of sister chromatid segregation (GO:0033046)3.09129525
95negative regulation of mitotic sister chromatid separation (GO:2000816)3.09129525
96negative regulation of mitotic sister chromatid segregation (GO:0033048)3.09129525
97regulation of nuclear cell cycle DNA replication (GO:0033262)3.08582445
98ribosomal large subunit biogenesis (GO:0042273)3.07470934
99mitotic spindle assembly checkpoint (GO:0007094)3.05618235
100regulation of double-strand break repair via homologous recombination (GO:0010569)3.03501782
101spindle assembly checkpoint (GO:0071173)3.02967850
102mitotic spindle checkpoint (GO:0071174)3.02920685
103rRNA methylation (GO:0031167)3.02323940
104negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.01960347
105kinetochore organization (GO:0051383)3.01426528
106spliceosomal complex assembly (GO:0000245)2.99109014
107regulation of mitotic metaphase/anaphase transition (GO:0030071)2.98418143
108cell cycle G1/S phase transition (GO:0044843)2.98108106
109G1/S transition of mitotic cell cycle (GO:0000082)2.98108106
110antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.96248158
111nucleotide-excision repair, DNA gap filling (GO:0006297)2.95667624
112positive regulation of mast cell activation (GO:0033005)2.95537801
113nuclear pore organization (GO:0006999)2.95209101
114nuclear envelope organization (GO:0006998)2.94672600
115germinal center formation (GO:0002467)2.94659789
116negative regulation of B cell apoptotic process (GO:0002903)2.94436557
117regulation of translation in response to stress (GO:0043555)2.94417485
1183-UTR-mediated mRNA stabilization (GO:0070935)2.93246193
119regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.93121764
120translational initiation (GO:0006413)2.92726768
121protein localization to chromosome (GO:0034502)2.92552556
122transcription-coupled nucleotide-excision repair (GO:0006283)2.92217745
123Arp2/3 complex-mediated actin nucleation (GO:0034314)2.91178007
124regulation of mast cell activation involved in immune response (GO:0033006)2.90672052
125histone exchange (GO:0043486)2.90666556
126positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.90486402
127leukocyte aggregation (GO:0070486)2.89656549
128myeloid leukocyte mediated immunity (GO:0002444)2.89564091
129cellular extravasation (GO:0045123)2.89077915
130pseudouridine synthesis (GO:0001522)2.88952913
131negative regulation of phagocytosis (GO:0050765)2.88292980
132somatic hypermutation of immunoglobulin genes (GO:0016446)2.88199749
133somatic diversification of immune receptors via somatic mutation (GO:0002566)2.88199749
134ubiquinone biosynthetic process (GO:0006744)2.87571792
135regulation of mitotic spindle organization (GO:0060236)2.86515873
136kinetochore assembly (GO:0051382)2.85911233
137regulation of B cell differentiation (GO:0045577)2.85809710
138negative regulation of ligase activity (GO:0051352)2.85679355
139negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.85679355
140microglial cell activation (GO:0001774)2.84660822
141ribosomal small subunit biogenesis (GO:0042274)2.83992127
142B cell mediated immunity (GO:0019724)2.82833547
143regulation of superoxide anion generation (GO:0032928)2.82583877
144negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.82497553
145RNA splicing, via transesterification reactions (GO:0000375)2.82452300
146RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.82432615
147mRNA splicing, via spliceosome (GO:0000398)2.82432615
148positive regulation of mast cell activation involved in immune response (GO:0033008)2.80172180
149positive regulation of mast cell degranulation (GO:0043306)2.80172180
150negative regulation of lymphocyte mediated immunity (GO:0002707)2.80089362
151regulation of interferon-beta biosynthetic process (GO:0045357)2.79454082
152myeloid cell activation involved in immune response (GO:0002275)2.79038720
153response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.76002184
154response to host (GO:0075136)2.76002184
155response to host defenses (GO:0052200)2.76002184
156regulation of myeloid leukocyte mediated immunity (GO:0002886)2.62986424
157positive regulation of granulocyte differentiation (GO:0030854)2.61542527
158leukocyte migration involved in inflammatory response (GO:0002523)2.58836806
159regulation of B cell apoptotic process (GO:0002902)2.58249654
160antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.54365045
161positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.53094511
162regulation of mast cell activation (GO:0033003)2.53047875
163regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.52987811
164poly(A)+ mRNA export from nucleus (GO:0016973)2.52299931
165negative regulation of leukocyte mediated immunity (GO:0002704)2.51574759
166ubiquinone metabolic process (GO:0006743)2.51391023
167leukocyte degranulation (GO:0043299)2.46415691
168negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.45234469
169purine deoxyribonucleotide catabolic process (GO:0009155)2.44926200
170detection of external biotic stimulus (GO:0098581)2.42357331
171positive thymic T cell selection (GO:0045059)2.42188116
172purine nucleotide salvage (GO:0032261)2.40542436
173deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.40473244
174negative thymic T cell selection (GO:0045060)2.39963320
175macrophage activation (GO:0042116)2.39443418
176response to interleukin-15 (GO:0070672)2.39383813
177negative T cell selection (GO:0043383)2.37524964
178cytochrome complex assembly (GO:0017004)2.37347397
179leukocyte mediated cytotoxicity (GO:0001909)2.32835489
180dosage compensation (GO:0007549)2.32667267
181amino sugar catabolic process (GO:0046348)2.30545063
182megakaryocyte development (GO:0035855)2.29053183
183regulation of leukocyte degranulation (GO:0043300)2.28388286
184NIK/NF-kappaB signaling (GO:0038061)2.27487880
185negative regulation of innate immune response (GO:0045824)2.26450542
186T cell homeostasis (GO:0043029)2.26220528
187detection of biotic stimulus (GO:0009595)2.24985675
188antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.24849650
189purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.23899935
190negative regulation of T cell mediated immunity (GO:0002710)2.23831670
191cellular response to interleukin-15 (GO:0071350)2.23445746
192quinone biosynthetic process (GO:1901663)2.23034836
193pinocytosis (GO:0006907)2.22667367
194purine-containing compound salvage (GO:0043101)2.22522623
195negative regulation of erythrocyte differentiation (GO:0045647)2.20927995
196regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.20462351
197positive regulation of isotype switching (GO:0045830)2.19651112

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.33096393
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.15949831
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.97360410
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.74583221
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.22437245
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.11100097
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.06571424
8ETS1_20019798_ChIP-Seq_JURKAT_Human2.97047127
9EST1_17652178_ChIP-ChIP_JURKAT_Human2.95615423
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.92529161
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.91329959
12* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.85906433
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.82424526
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.76136672
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.65831757
16SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.65186359
17IRF8_22096565_ChIP-ChIP_GC-B_Human2.64230219
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.52506772
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.41400861
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.40318319
21IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.34495508
22AR_21909140_ChIP-Seq_LNCAP_Human2.33186576
23* XRN2_22483619_ChIP-Seq_HELA_Human2.31889638
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.31764507
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.31118065
26MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.28447613
27MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.26237220
28BP1_19119308_ChIP-ChIP_Hs578T_Human2.18101491
29* SPI1_23547873_ChIP-Seq_NB4_Human2.16425227
30* VDR_23849224_ChIP-Seq_CD4+_Human2.13415558
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.06070093
32NANOG_18555785_ChIP-Seq_MESCs_Mouse2.01406465
33GABP_19822575_ChIP-Seq_HepG2_Human1.99112518
34CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.97261020
35RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.93323883
36VDR_24763502_ChIP-Seq_THP-1_Human1.91887081
37DCP1A_22483619_ChIP-Seq_HELA_Human1.90765858
38* FOXP3_21729870_ChIP-Seq_TREG_Human1.89515117
39CIITA_25753668_ChIP-Seq_RAJI_Human1.88391054
40MYCN_18555785_ChIP-Seq_MESCs_Mouse1.88027164
41THAP11_20581084_ChIP-Seq_MESCs_Mouse1.87468220
42CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.87203172
43* MAF_26560356_Chip-Seq_TH1_Human1.84559973
44MYC_22102868_ChIP-Seq_BL_Human1.84059387
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.83407232
46EGR1_19374776_ChIP-ChIP_THP-1_Human1.83311699
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.82993796
48MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.78574973
49* UTX_26944678_Chip-Seq_JUKART_Human1.75820037
50* MYB_26560356_Chip-Seq_TH2_Human1.75609419
51YY1_21170310_ChIP-Seq_MESCs_Mouse1.74069330
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73838491
53* TTF2_22483619_ChIP-Seq_HELA_Human1.72201436
54MAF_26560356_Chip-Seq_TH2_Human1.67105570
55* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.64296304
56* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62013077
57* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.59878706
58ELF1_17652178_ChIP-ChIP_JURKAT_Human1.59147215
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58945953
60KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58733496
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.57340013
62CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52801338
63STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52731612
64SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50060074
65* SPI1_23127762_ChIP-Seq_K562_Human1.49951217
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.48838761
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.48783363
68STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.48243025
69SCL_19346495_ChIP-Seq_HPC-7_Human1.47166877
70KDM5A_27292631_Chip-Seq_BREAST_Human1.46297017
71* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.45936404
72* MYB_26560356_Chip-Seq_TH1_Human1.44548631
73FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.43534596
74SRF_21415370_ChIP-Seq_HL-1_Mouse1.43175831
75TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.40045970
76E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38977329
77IRF8_27001747_Chip-Seq_BMDM_Mouse1.34079355
78NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.33182858
79RUNX1_22412390_ChIP-Seq_EML_Mouse1.32642217
80STAT3_1855785_ChIP-Seq_MESCs_Mouse1.32154362
81TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.31746687
82POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.31121341
83SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30219563
84* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.29285411
85* TP63_19390658_ChIP-ChIP_HaCaT_Human1.28314652
86MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25280807
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.25029547
88HOXB4_20404135_ChIP-ChIP_EML_Mouse1.24441836
89RUNX_20019798_ChIP-Seq_JUKART_Human1.22113438
90BCL6_27268052_Chip-Seq_Bcells_Human1.20628279
91PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.18993353
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.18181200
93FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.17127599
94* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15937995
95SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15629617
96ELK1_19687146_ChIP-ChIP_HELA_Human1.14993748
97LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14542566
98DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.13014292
99CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.12804027
100NANOG_21062744_ChIP-ChIP_HESCs_Human1.11979248
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11404417
102* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10917316
103ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10435739
104* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.10398005
105LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09896234
106NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09799678
107GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09460665
108TFEB_21752829_ChIP-Seq_HELA_Human1.08924266
109* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06779041
110BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05912602
111* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.05734798
112SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.05604514
113HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.05299919
114KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03695947
115BCOR_27268052_Chip-Seq_Bcells_Human1.03369523
116BRD4_27068464_Chip-Seq_AML-cells_Mouse1.02830957
117* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02524103
118TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01760471
119MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.00568003
120CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00212332
121VDR_21846776_ChIP-Seq_THP-1_Human0.99657225
122ELF1_20517297_ChIP-Seq_JURKAT_Human0.99447187
123* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.99442195
124ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.98511698
125* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98442564
126NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.96756319
127ELK1_22589737_ChIP-Seq_MCF10A_Human0.96680459
128CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.95361251
129* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.94801002
130SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.93893814
131OCT4_18692474_ChIP-Seq_MEFs_Mouse0.92669781
132* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.90785428
133SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89657211
134NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.87066242
135TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.86123595
136SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.84597863
137NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.83088144
138TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82977260
139* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.80045020
140GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.79803802
141ZNF263_19887448_ChIP-Seq_K562_Human0.79161773
142CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.77846293

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.57973376
2MP0004957_abnormal_blastocyst_morpholog4.45023108
3MP0003111_abnormal_nucleus_morphology4.30225726
4MP0010094_abnormal_chromosome_stability4.04083828
5MP0003077_abnormal_cell_cycle3.73993112
6MP0003436_decreased_susceptibility_to3.19249983
7MP0003123_paternal_imprinting2.98836893
8MP0008057_abnormal_DNA_replication2.77374097
9MP0008058_abnormal_DNA_repair2.61150615
10MP0001835_abnormal_antigen_presentation2.60535660
11MP0003303_peritoneal_inflammation2.56170922
12MP0008007_abnormal_cellular_replicative2.53174637
13MP0003724_increased_susceptibility_to2.52402868
14MP0001800_abnormal_humoral_immune2.51857311
15MP0005671_abnormal_response_to2.49262421
16MP0008932_abnormal_embryonic_tissue2.45432711
17MP0001730_embryonic_growth_arrest2.28361542
18MP0002419_abnormal_innate_immunity2.28170052
19MP0009785_altered_susceptibility_to2.27801501
20MP0002653_abnormal_ependyma_morphology2.22639083
21MP0000350_abnormal_cell_proliferation2.19268969
22MP0005025_abnormal_response_to2.17997562
23MP0005387_immune_system_phenotype2.17537885
24MP0001790_abnormal_immune_system2.17537885
25MP0002723_abnormal_immune_serum2.16072034
26MP0000685_abnormal_immune_system2.11729526
27MP0005000_abnormal_immune_tolerance2.08476325
28MP0002420_abnormal_adaptive_immunity2.07915620
29MP0001819_abnormal_immune_cell2.04601738
30MP0002452_abnormal_antigen_presenting2.04488834
31MP0005380_embryogenesis_phenotype1.96911724
32MP0001672_abnormal_embryogenesis/_devel1.96911724
33MP0002396_abnormal_hematopoietic_system1.92545828
34MP0002148_abnormal_hypersensitivity_rea1.90776665
35MP0003718_maternal_effect1.90311451
36MP0003646_muscle_fatigue1.89557805
37MP0003786_premature_aging1.85893895
38MP0003984_embryonic_growth_retardation1.84838202
39MP0005058_abnormal_lysosome_morphology1.81913728
40MP0002088_abnormal_embryonic_growth/wei1.80201535
41MP0001697_abnormal_embryo_size1.77068972
42MP0009278_abnormal_bone_marrow1.75774677
43MP0006082_CNS_inflammation1.75023465
44MP0000716_abnormal_immune_system1.71926136
45MP0005397_hematopoietic_system_phenotyp1.70083725
46MP0001545_abnormal_hematopoietic_system1.70083725
47MP0000490_abnormal_crypts_of1.64370072
48MP0005075_abnormal_melanosome_morpholog1.64232115
49MP0005451_abnormal_body_composition1.63238600
50MP0002080_prenatal_lethality1.62549575
51MP0010030_abnormal_orbit_morphology1.61289687
52MP0005464_abnormal_platelet_physiology1.58674594
53MP0003567_abnormal_fetal_cardiomyocyte1.57316929
54MP0004084_abnormal_cardiac_muscle1.57051623
55MP0002085_abnormal_embryonic_tissue1.56682943
56MP0003172_abnormal_lysosome_physiology1.52491929
57MP0002405_respiratory_system_inflammati1.49485218
58MP0004381_abnormal_hair_follicle1.46864770
59MP0003119_abnormal_digestive_system1.46689231
60MP0009764_decreased_sensitivity_to1.45533352
61MP0000015_abnormal_ear_pigmentation1.44465254
62MP0002084_abnormal_developmental_patter1.39958814
63MP0000313_abnormal_cell_death1.39418334
64MP0008877_abnormal_DNA_methylation1.38278133
65MP0002277_abnormal_respiratory_mucosa1.37280547
66MP0003315_abnormal_perineum_morphology1.36829653
67MP0002086_abnormal_extraembryonic_tissu1.36176953
68MP0003221_abnormal_cardiomyocyte_apopto1.34995574
69MP0006292_abnormal_olfactory_placode1.34483372
70MP0003890_abnormal_embryonic-extraembry1.33180738
71MP0000749_muscle_degeneration1.32730915
72MP0004197_abnormal_fetal_growth/weight/1.31712829
73MP0000566_synostosis1.30125298
74MP0001845_abnormal_inflammatory_respons1.29694478
75MP0001661_extended_life_span1.28886253
76MP0008469_abnormal_protein_level1.28461399
77MP0004133_heterotaxia1.27568296
78MP0010352_gastrointestinal_tract_polyps1.25833529
79MP0003806_abnormal_nucleotide_metabolis1.18073316
80MP0002019_abnormal_tumor_incidence1.17982294
81MP0001533_abnormal_skeleton_physiology1.16868932
82MP0003121_genomic_imprinting1.16491901
83MP0003828_pulmonary_edema1.16433493
84MP0004233_abnormal_muscle_weight1.16095636
85MP0004264_abnormal_extraembryonic_tissu1.16021183
86MP0000372_irregular_coat_pigmentation1.15866407
87MP0002095_abnormal_skin_pigmentation1.11156040
88MP0010307_abnormal_tumor_latency1.09892491
89MP0003878_abnormal_ear_physiology1.07690480
90MP0005377_hearing/vestibular/ear_phenot1.07690480
91MP0008961_abnormal_basal_metabolism1.07605332
92MP0000343_altered_response_to1.06959676
93MP0010155_abnormal_intestine_physiology1.05753976
94MP0009672_abnormal_birth_weight1.04000692
95MP0000750_abnormal_muscle_regeneration1.02713473
96MP0009333_abnormal_splenocyte_physiolog1.02416356
97MP0000678_abnormal_parathyroid_gland1.01617609
98MP0008789_abnormal_olfactory_epithelium1.00503514
99MP0001853_heart_inflammation1.00240354
100MP0000358_abnormal_cell_content/1.00206444
101MP0005310_abnormal_salivary_gland0.98193142
102MP0003183_abnormal_peptide_metabolism0.97610760
103MP0004215_abnormal_myocardial_fiber0.96327833
104MP0001764_abnormal_homeostasis0.95678398
105MP0000703_abnormal_thymus_morphology0.94218591
106MP0002210_abnormal_sex_determination0.92353492
107MP0004145_abnormal_muscle_electrophysio0.90917412
108MP0002269_muscular_atrophy0.89957828
109MP0003763_abnormal_thymus_physiology0.89595896
110MP0004808_abnormal_hematopoietic_stem0.89585094
111MP0005319_abnormal_enzyme/_coenzyme0.89447483
112MP0001293_anophthalmia0.89101410
113MP0006036_abnormal_mitochondrial_physio0.88747678
114MP0005174_abnormal_tail_pigmentation0.88660866
115MP0002332_abnormal_exercise_endurance0.88556278
116MP0005076_abnormal_cell_differentiation0.88516443
117MP0000747_muscle_weakness0.87828442
118MP0001119_abnormal_female_reproductive0.87417717
119MP0006035_abnormal_mitochondrial_morpho0.87313967
120MP0002837_dystrophic_cardiac_calcinosis0.87242296
121MP0001145_abnormal_male_reproductive0.84397279
122MP0002127_abnormal_cardiovascular_syste0.84197299
123MP0002972_abnormal_cardiac_muscle0.83958482
124MP0004147_increased_porphyrin_level0.83463948
125MP0000733_abnormal_muscle_development0.79989927
126MP0003186_abnormal_redox_activity0.79938903
127MP0000537_abnormal_urethra_morphology0.79108956
128MP0002106_abnormal_muscle_physiology0.79021964
129MP0000751_myopathy0.78161577
130MP0002132_abnormal_respiratory_system0.77952210
131MP0002722_abnormal_immune_system0.77879613
132MP0002111_abnormal_tail_morphology0.77730578
133MP0003656_abnormal_erythrocyte_physiolo0.77513967
134MP0005384_cellular_phenotype0.77086945
135MP0005330_cardiomyopathy0.76399537
136MP0004510_myositis0.75385545
137MP0004036_abnormal_muscle_relaxation0.74449353
138MP0009840_abnormal_foam_cell0.74278685
139MP0005266_abnormal_metabolism0.74205258
140MP0003705_abnormal_hypodermis_morpholog0.73630602
141MP0005394_taste/olfaction_phenotype0.73539590
142MP0005499_abnormal_olfactory_system0.73539590
143MP0000428_abnormal_craniofacial_morphol0.73010546
144MP0000653_abnormal_sex_gland0.71405256
145MP0000689_abnormal_spleen_morphology0.70074991
146MP0005584_abnormal_enzyme/coenzyme_acti0.68940652
147MP0010630_abnormal_cardiac_muscle0.68728660
148MP0005621_abnormal_cell_physiology0.68315424
149MP0003115_abnormal_respiratory_system0.68101684
150MP0008260_abnormal_autophagy0.67724095
151MP0002398_abnormal_bone_marrow0.67283146
152MP0001986_abnormal_taste_sensitivity0.66031406
153MP0009053_abnormal_anal_canal0.65277309
154MP0001929_abnormal_gametogenesis0.65274996
155MP0000266_abnormal_heart_morphology0.64287349
156MP0003137_abnormal_impulse_conducting0.62436345
157MP0002751_abnormal_autonomic_nervous0.61378640
158MP0002429_abnormal_blood_cell0.60667743
159MP0002932_abnormal_joint_morphology0.59711627
160MP0002092_abnormal_eye_morphology0.59505424
161MP0002160_abnormal_reproductive_system0.59410771
162MP0003938_abnormal_ear_development0.59245343

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.26327430
2Breast hypoplasia (HP:0003187)4.64415471
3Abnormality of the anterior horn cell (HP:0006802)4.10213651
4Degeneration of anterior horn cells (HP:0002398)4.10213651
5Eczematoid dermatitis (HP:0000976)4.07845141
6Recurrent abscess formation (HP:0002722)4.01363051
7Stomatitis (HP:0010280)3.88218308
8Recurrent bacterial skin infections (HP:0005406)3.80016309
9Carpal bone hypoplasia (HP:0001498)3.66694125
10Increased neuronal autofluorescent lipopigment (HP:0002074)3.53752960
11Elevated erythrocyte sedimentation rate (HP:0003565)3.53022605
12Patellar aplasia (HP:0006443)3.51341579
13Mediastinal lymphadenopathy (HP:0100721)3.48230386
14Obstructive lung disease (HP:0006536)3.46123432
15Chronic obstructive pulmonary disease (HP:0006510)3.46123432
16Aplasia/Hypoplasia of the patella (HP:0006498)3.39797749
17Increased cerebral lipofuscin (HP:0011813)3.37462696
18Abnormality of macrophages (HP:0004311)3.30790477
19Recurrent fungal infections (HP:0002841)3.28872994
20Ragged-red muscle fibers (HP:0003200)3.22505148
21Recurrent gram-negative bacterial infections (HP:0005420)3.17008357
22Rough bone trabeculation (HP:0100670)3.14140202
23Colon cancer (HP:0003003)3.13289875
24Meningitis (HP:0001287)3.08838850
25Ependymoma (HP:0002888)3.04658330
26Multiple enchondromatosis (HP:0005701)3.03121746
27Myositis (HP:0100614)3.02699425
28Cerebral hypomyelination (HP:0006808)2.99110359
29Reticulocytopenia (HP:0001896)2.99036251
30Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.92827168
31Retrobulbar optic neuritis (HP:0100654)2.87276377
32Optic neuritis (HP:0100653)2.87276377
33Microretrognathia (HP:0000308)2.83422948
34Encephalitis (HP:0002383)2.82971717
35Loss of speech (HP:0002371)2.81142797
36Abnormal mitochondria in muscle tissue (HP:0008316)2.78984920
37Panhypogammaglobulinemia (HP:0003139)2.77344657
38Selective tooth agenesis (HP:0001592)2.77330753
39Acute necrotizing encephalopathy (HP:0006965)2.76837345
40Progressive muscle weakness (HP:0003323)2.76065098
41Orchitis (HP:0100796)2.71840324
42Absent radius (HP:0003974)2.71693627
43Oral leukoplakia (HP:0002745)2.70097327
44Recurrent skin infections (HP:0001581)2.68500540
45Gastrointestinal infarctions (HP:0005244)2.67292386
46Chronic mucocutaneous candidiasis (HP:0002728)2.66550140
47Recurrent cutaneous fungal infections (HP:0011370)2.66550140
48Medulloblastoma (HP:0002885)2.66108199
49Hepatosplenomegaly (HP:0001433)2.63578575
50Hypochromic microcytic anemia (HP:0004840)2.63163905
51Atrophy/Degeneration involving motor neurons (HP:0007373)2.60996588
52Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.60688696
53Premature ovarian failure (HP:0008209)2.59027093
54Petechiae (HP:0000967)2.57087443
55Progressive microcephaly (HP:0000253)2.53653006
56Abnormal trabecular bone morphology (HP:0100671)2.52417426
57Aplasia involving forearm bones (HP:0009822)2.51954134
58Absent forearm bone (HP:0003953)2.51954134
59Trismus (HP:0000211)2.50884071
60Impulsivity (HP:0100710)2.50471336
61Abnormality of the ileum (HP:0001549)2.49132019
62Mitochondrial inheritance (HP:0001427)2.47585240
63Urticaria (HP:0001025)2.45432981
64Meckel diverticulum (HP:0002245)2.45000934
65Secondary amenorrhea (HP:0000869)2.42294687
66Cleft eyelid (HP:0000625)2.42048440
67Acute hepatic failure (HP:0006554)2.41402027
68Irregular epiphyses (HP:0010582)2.40460197
69Absent thumb (HP:0009777)2.37821448
70Acute encephalopathy (HP:0006846)2.37350007
71Rhabdomyosarcoma (HP:0002859)2.37102117
72Microvesicular hepatic steatosis (HP:0001414)2.36630963
73IgM deficiency (HP:0002850)2.36217271
74Increased CSF lactate (HP:0002490)2.35410810
75Chest pain (HP:0100749)2.32707426
76Increased IgE level (HP:0003212)2.31975271
77Entropion (HP:0000621)2.31768575
78Horseshoe kidney (HP:0000085)2.31429628
79Abnormality of the preputium (HP:0100587)2.31153249
80Vasculitis (HP:0002633)2.30823581
81Granulocytopenia (HP:0001913)2.28841344
82Absent rod-and cone-mediated responses on ERG (HP:0007688)2.28151735
83Chromosomal breakage induced by crosslinking agents (HP:0003221)2.27831165
84Neoplasm of the pancreas (HP:0002894)2.27176481
85Increased IgM level (HP:0003496)2.23757683
86Chromsome breakage (HP:0040012)2.23189839
87Abnormality of the umbilical cord (HP:0010881)2.20149748
88Exercise-induced muscle cramps (HP:0003710)2.19972553
89Nausea (HP:0002018)2.18296180
90Progressive macrocephaly (HP:0004481)2.18069100
91Respiratory difficulties (HP:0002880)2.17599595
92Agnosia (HP:0010524)2.17236426
93Ureteral duplication (HP:0000073)2.17083995
94Lymphopenia (HP:0001888)2.16415303
95Patent foramen ovale (HP:0001655)2.14304847
96Aplastic anemia (HP:0001915)2.12833188
97Abnormal number of erythroid precursors (HP:0012131)2.12440705
98Abnormal delayed hypersensitivity skin test (HP:0002963)2.11433866
99Duodenal stenosis (HP:0100867)2.10680226
100Small intestinal stenosis (HP:0012848)2.10680226
101Rhabdomyolysis (HP:0003201)2.10398242
102Myopathic facies (HP:0002058)2.10170970
103Keratoconjunctivitis sicca (HP:0001097)2.10122855
104Aplasia/Hypoplasia of the uvula (HP:0010293)2.09495684
105Oligodactyly (HP:0012165)2.09477698
106Hepatic necrosis (HP:0002605)2.09444207
107Abnormality of chromosome stability (HP:0003220)2.08989862
108Hepatocellular necrosis (HP:0001404)2.08975648
109Keratoconjunctivitis (HP:0001096)2.07669465
110Abnormality of cells of the erythroid lineage (HP:0012130)2.07309397
111Delayed epiphyseal ossification (HP:0002663)2.05661717
112Decreased electroretinogram (ERG) amplitude (HP:0000654)2.02976013
113Abnormality of alanine metabolism (HP:0010916)2.02665951
114Hyperalaninemia (HP:0003348)2.02665951
115Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.02665951
116Agammaglobulinemia (HP:0004432)2.01220247
117Abnormal gallbladder physiology (HP:0012438)2.00171364
118Cholecystitis (HP:0001082)2.00171364
119Lactic acidosis (HP:0003128)1.99274840
120Triphalangeal thumb (HP:0001199)1.98925377
121Angiofibromas (HP:0010615)1.97984296
122Adenoma sebaceum (HP:0009720)1.97984296
123Type 2 muscle fiber atrophy (HP:0003554)1.95799021
124Aplasia/Hypoplasia of the sternum (HP:0006714)1.94604001
125Abnormal pancreas size (HP:0012094)1.94273119
126Abnormal number of incisors (HP:0011064)1.93524229
127Hypoplasia of the capital femoral epiphysis (HP:0003090)1.93411686
128Hyperglycinemia (HP:0002154)1.93341075
129Gout (HP:0001997)1.93162378
130Abnormality of the duodenum (HP:0002246)1.92605932
131Prolonged bleeding time (HP:0003010)1.91851773
132Paralysis (HP:0003470)1.91373620
133Aplasia/Hypoplasia of the thymus (HP:0010515)1.90809238
134Type I transferrin isoform profile (HP:0003642)1.89867269
135Muscle fiber atrophy (HP:0100295)1.89722435
136Abnormality of T cells (HP:0002843)1.89639449
137Atresia of the external auditory canal (HP:0000413)1.89048317
138Recurrent viral infections (HP:0004429)1.88604030
139Anorexia (HP:0002039)1.88514145
140Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.85590236
141Macrocytic anemia (HP:0001972)1.85210311
142B lymphocytopenia (HP:0010976)1.84260707
143Bone marrow hypocellularity (HP:0005528)1.83892308
144Cellular immunodeficiency (HP:0005374)1.82993702
145Exercise intolerance (HP:0003546)1.82320147
146Slender long bone (HP:0003100)1.82151946
147Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.81833820
148Polyneuropathy (HP:0001271)1.81630810
149Muscle fiber splitting (HP:0003555)1.81353467
150Shawl scrotum (HP:0000049)1.80856213
151Sparse eyelashes (HP:0000653)1.80805804
152Neoplasm of striated muscle (HP:0009728)1.79403795
153Basal cell carcinoma (HP:0002671)1.79317761
154Muscle fiber inclusion bodies (HP:0100299)1.79239362
155Sloping forehead (HP:0000340)1.78391948
156Optic nerve coloboma (HP:0000588)1.78350807
157Abnormality of fatty-acid metabolism (HP:0004359)1.78308342
158Abnormality of T cell physiology (HP:0011840)1.77520752
159Glossoptosis (HP:0000162)1.76910669
160Hyperglycinuria (HP:0003108)1.76778250
161Abnormality of cells of the lymphoid lineage (HP:0012140)1.76531488
162Nemaline bodies (HP:0003798)1.76189118
163Eosinophilia (HP:0001880)1.75650911
164Abnormality of lateral ventricle (HP:0030047)1.75553277
165Abnormality of B cell number (HP:0010975)1.74972465
166Myelodysplasia (HP:0002863)1.74531345
167Glioma (HP:0009733)1.74307286
168Increased serum lactate (HP:0002151)1.74236710
169Cellulitis (HP:0100658)1.73831870
170Sepsis (HP:0100806)1.73480995
171Severe combined immunodeficiency (HP:0004430)1.73352464
172Hemoptysis (HP:0002105)1.73342857
173Cerebral edema (HP:0002181)1.73268198
174Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.72858793
175Abnormal protein N-linked glycosylation (HP:0012347)1.72812958
176Abnormal protein glycosylation (HP:0012346)1.72812958
177Abnormal glycosylation (HP:0012345)1.72812958
178Intestinal atresia (HP:0011100)1.72274991
179Unsteady gait (HP:0002317)1.71260426
180Tracheoesophageal fistula (HP:0002575)1.71036042
181Neoplasm of the colon (HP:0100273)1.70785011
182Breast aplasia (HP:0100783)1.69541861
183Sparse lateral eyebrow (HP:0005338)1.69243870
184Supernumerary spleens (HP:0009799)1.68428080
185Premature graying of hair (HP:0002216)1.68338353
186Overlapping toe (HP:0001845)1.67687396
187Aplasia/Hypoplasia of the breasts (HP:0010311)1.67595845
188Hypoplasia of the radius (HP:0002984)1.67522869
189Abnormal lung lobation (HP:0002101)1.67070885
190Aplasia/Hypoplasia of the sacrum (HP:0008517)1.66731082
191Areflexia of lower limbs (HP:0002522)1.66536756
192Abnormality of the heme biosynthetic pathway (HP:0010472)1.65060664
193Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.63535652
194Absent epiphyses (HP:0010577)1.63535652
195Ovarian neoplasm (HP:0100615)1.63102962
196Diastasis recti (HP:0001540)1.62208726

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.07540932
2WEE14.42817478
3RIPK44.18612362
4EIF2AK13.53251067
5CDC72.99218473
6BRSK22.95503072
7NEK22.78084421
8BLK2.75816637
9NEK12.54005759
10ACVR1B2.50044674
11SRPK12.44714207
12IRAK42.36173765
13TSSK62.33317482
14TTK2.31864446
15BRSK12.30509116
16CDK192.30252085
17TNK22.21964599
18SIK32.14088593
19RPS6KA42.08228482
20PLK12.02918354
21TYK21.95452187
22NME21.93016396
23PLK41.90918125
24TXK1.85068202
25CDK71.79352730
26FES1.78916071
27CDK121.73141608
28DYRK31.72266206
29CHEK21.64158362
30PASK1.63264275
31CSK1.62647205
32STK38L1.62149549
33SYK1.54531362
34PLK31.54411897
35EIF2AK31.50300200
36TESK21.49857228
37MKNK11.48944117
38MKNK21.48771830
39AURKB1.47171113
40AURKA1.43108098
41BCKDK1.40319876
42CDK41.40039805
43BTK1.37045868
44VRK11.35083597
45LYN1.35074145
46STK161.32287035
47FGR1.30079203
48STK101.22576186
49TGFBR11.21386382
50EPHA21.20841765
51ZAK1.20692039
52OBSCN1.18558288
53ATR1.17451289
54MAP3K101.14648349
55PRPF4B1.13519494
56CHEK11.08449563
57JAK31.07168190
58HCK1.05984612
59SIK21.05125310
60MAP3K81.04273283
61TAOK11.01548492
62RPS6KB21.00743640
63PDK40.98239668
64PDK30.98239668
65TIE10.97062156
66CCNB10.94790629
67FLT30.91108313
68MAPK110.90982639
69PAK40.90965595
70TRIB30.90614182
71CSF1R0.90151363
72MELK0.90102685
73LCK0.89845938
74TBK10.88027050
75LATS20.87041746
76MAPK120.86457222
77YES10.82994964
78STK40.82902954
79CDK80.82616055
80JAK20.80629676
81AKT30.80522886
82STK240.79904567
83PRKCI0.78937019
84PKN20.77440666
85ITK0.77008300
86IKBKE0.76954652
87KIT0.76698570
88MAP4K10.76518382
89MAP3K30.75506638
90CDK20.75050341
91IKBKB0.74405342
92BRAF0.70624173
93MATK0.70513449
94PIM10.69205483
95MARK20.65802380
96KDR0.64256366
97TLK10.63376997
98KSR20.62627758
99TAOK20.61058558
100LRRK20.59700521
101PAK10.59688354
102TRIM280.58458381
103MAP3K10.58373437
104GRK60.58259934
105ATM0.57492760
106PKN10.57275598
107CSNK2A10.56616582
108EEF2K0.55854308
109PIM20.55327040
110EPHB10.54629551
111MAP3K110.52889837
112MAP2K30.52538953
113CSNK1G30.50548403
114PDK20.49115922
115STK30.48510840
116CSNK2A20.47485579
117CDK10.47161675
118EIF2AK20.46289519
119RAF10.45570163
120BMPR20.44718819
121DYRK1B0.44429083
122MAPK70.42943797
123MAP2K60.41292006
124ALK0.41246072
125VRK20.40779928
126ZAP700.40415534
127PIK3CG0.40113631
128ILK0.39145212
129PRKCQ0.38504666
130MTOR0.37708709
131BRD40.37308793
132MARK30.36944481
133PTK2B0.36695890
134PRKD20.34867724
135CAMK40.34176912
136PDPK10.34128462
137PRKCZ0.33761178
138RPS6KL10.33060794
139RPS6KC10.33060794
140NEK90.32138870
141FRK0.31600932
142PDK10.30394166
143SCYL20.30268365
144TESK10.30194452
145MAPKAPK30.29104747
146PINK10.28990652
147FYN0.28596368
148RPS6KA60.27429008
149LATS10.27293536
150CAMK10.27259674
151TEC0.26768551
152RPS6KA10.26283695
153IRAK30.26016757
154MAP3K50.25954249
155NME10.25452559
156MAPKAPK20.25312027
157ERN10.25278883
158MAP3K60.24510820
159AKT20.24024450
160PRKAA10.23248599

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.63889150
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.85717575
3Mismatch repair_Homo sapiens_hsa034303.84166852
4RNA polymerase_Homo sapiens_hsa030203.39439033
5Proteasome_Homo sapiens_hsa030503.29242691
6RNA transport_Homo sapiens_hsa030133.27792539
7Spliceosome_Homo sapiens_hsa030403.23866584
8Cell cycle_Homo sapiens_hsa041102.99600899
9Base excision repair_Homo sapiens_hsa034102.95075010
10Ribosome_Homo sapiens_hsa030102.80883653
11Homologous recombination_Homo sapiens_hsa034402.71910609
12Fatty acid elongation_Homo sapiens_hsa000622.70315070
13Nucleotide excision repair_Homo sapiens_hsa034202.56272654
14Pyrimidine metabolism_Homo sapiens_hsa002402.37094322
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.23761925
16Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.04842048
17Osteoclast differentiation_Homo sapiens_hsa043802.02000269
18Vitamin B6 metabolism_Homo sapiens_hsa007501.97982981
19Fanconi anemia pathway_Homo sapiens_hsa034601.94951164
20One carbon pool by folate_Homo sapiens_hsa006701.86780645
21Collecting duct acid secretion_Homo sapiens_hsa049661.86054884
22Basal transcription factors_Homo sapiens_hsa030221.81017555
23Leishmaniasis_Homo sapiens_hsa051401.80858712
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.80058039
252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.78267549
26RNA degradation_Homo sapiens_hsa030181.73702641
27Non-homologous end-joining_Homo sapiens_hsa034501.72885642
28Staphylococcus aureus infection_Homo sapiens_hsa051501.71997849
29p53 signaling pathway_Homo sapiens_hsa041151.64160072
30Oxidative phosphorylation_Homo sapiens_hsa001901.61153895
31mRNA surveillance pathway_Homo sapiens_hsa030151.57671261
32* Tuberculosis_Homo sapiens_hsa051521.56394435
33B cell receptor signaling pathway_Homo sapiens_hsa046621.54739225
34Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.49759019
35Purine metabolism_Homo sapiens_hsa002301.36218154
36Folate biosynthesis_Homo sapiens_hsa007901.35922997
37Graft-versus-host disease_Homo sapiens_hsa053321.30253487
38Allograft rejection_Homo sapiens_hsa053301.29775448
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.28827732
40Biosynthesis of amino acids_Homo sapiens_hsa012301.28370684
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26047301
42Viral myocarditis_Homo sapiens_hsa054161.25780517
43Autoimmune thyroid disease_Homo sapiens_hsa053201.25155872
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.25038007
45Pentose phosphate pathway_Homo sapiens_hsa000301.20110845
46Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19879422
47Cyanoamino acid metabolism_Homo sapiens_hsa004601.19858747
48Selenocompound metabolism_Homo sapiens_hsa004501.19502637
49NF-kappa B signaling pathway_Homo sapiens_hsa040641.16946075
50Epstein-Barr virus infection_Homo sapiens_hsa051691.15892072
51Carbon metabolism_Homo sapiens_hsa012001.10019214
52Cysteine and methionine metabolism_Homo sapiens_hsa002701.08997105
53NOD-like receptor signaling pathway_Homo sapiens_hsa046211.07879121
54Hematopoietic cell lineage_Homo sapiens_hsa046401.05932806
55Oocyte meiosis_Homo sapiens_hsa041141.05339417
56T cell receptor signaling pathway_Homo sapiens_hsa046601.04433962
57Fructose and mannose metabolism_Homo sapiens_hsa000511.03568571
58Drug metabolism - other enzymes_Homo sapiens_hsa009831.03220978
59Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.02982293
60SNARE interactions in vesicular transport_Homo sapiens_hsa041301.02917535
61Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.02574377
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01120845
63Phagosome_Homo sapiens_hsa041450.98807550
64Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.97566913
65RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.96102894
66Lysosome_Homo sapiens_hsa041420.96076472
67Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95903688
68Fatty acid metabolism_Homo sapiens_hsa012120.94795840
69Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93467063
70Type I diabetes mellitus_Homo sapiens_hsa049400.93240239
71Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91126972
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87060392
73Herpes simplex infection_Homo sapiens_hsa051680.86950613
74Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.86424408
75Sulfur relay system_Homo sapiens_hsa041220.86373427
76Peroxisome_Homo sapiens_hsa041460.85941002
77Shigellosis_Homo sapiens_hsa051310.83459104
78Malaria_Homo sapiens_hsa051440.83019503
79Regulation of autophagy_Homo sapiens_hsa041400.82389446
80Thyroid cancer_Homo sapiens_hsa052160.81795732
81Notch signaling pathway_Homo sapiens_hsa043300.78663341
82Galactose metabolism_Homo sapiens_hsa000520.76609009
83Chemokine signaling pathway_Homo sapiens_hsa040620.74180412
84HTLV-I infection_Homo sapiens_hsa051660.71717701
85Rheumatoid arthritis_Homo sapiens_hsa053230.69482553
86Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.68857966
87Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68454777
88Viral carcinogenesis_Homo sapiens_hsa052030.68120244
89Intestinal immune network for IgA production_Homo sapiens_hsa046720.67457702
90* Antigen processing and presentation_Homo sapiens_hsa046120.66586149
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.65731312
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64420090
93Glutathione metabolism_Homo sapiens_hsa004800.59797504
94Cardiac muscle contraction_Homo sapiens_hsa042600.56576844
95Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.56410632
96Asthma_Homo sapiens_hsa053100.56387965
97Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56343090
98Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55532229
99Hippo signaling pathway_Homo sapiens_hsa043900.54452619
100Primary immunodeficiency_Homo sapiens_hsa053400.52373326
101Propanoate metabolism_Homo sapiens_hsa006400.52219203
102Systemic lupus erythematosus_Homo sapiens_hsa053220.50394587
103Alzheimers disease_Homo sapiens_hsa050100.50175796
104Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49732941
105Other glycan degradation_Homo sapiens_hsa005110.48898093
106beta-Alanine metabolism_Homo sapiens_hsa004100.48042085
107MicroRNAs in cancer_Homo sapiens_hsa052060.46046694
108Huntingtons disease_Homo sapiens_hsa050160.45631705
109Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43823249
110Salmonella infection_Homo sapiens_hsa051320.43540704
111Basal cell carcinoma_Homo sapiens_hsa052170.42502356
112Circadian rhythm_Homo sapiens_hsa047100.39701580
113Small cell lung cancer_Homo sapiens_hsa052220.37162993
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37039701
115HIF-1 signaling pathway_Homo sapiens_hsa040660.34470484
116Legionellosis_Homo sapiens_hsa051340.33352393
117Hedgehog signaling pathway_Homo sapiens_hsa043400.31857163
118Protein export_Homo sapiens_hsa030600.31138971
119mTOR signaling pathway_Homo sapiens_hsa041500.30937730
120Metabolic pathways_Homo sapiens_hsa011000.29171392
121Parkinsons disease_Homo sapiens_hsa050120.27822986
122Colorectal cancer_Homo sapiens_hsa052100.24115229
123Apoptosis_Homo sapiens_hsa042100.22982608
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.22528714
125Maturity onset diabetes of the young_Homo sapiens_hsa049500.22299328
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.21380472
127Lysine degradation_Homo sapiens_hsa003100.21034075
128TGF-beta signaling pathway_Homo sapiens_hsa043500.20013385
129Acute myeloid leukemia_Homo sapiens_hsa052210.19397303
130Bladder cancer_Homo sapiens_hsa052190.18994452
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.18754103
132Measles_Homo sapiens_hsa051620.17903018
133Longevity regulating pathway - mammal_Homo sapiens_hsa042110.16124879
134Arachidonic acid metabolism_Homo sapiens_hsa005900.15759945
135Influenza A_Homo sapiens_hsa051640.15740046
136N-Glycan biosynthesis_Homo sapiens_hsa005100.15520244
137Hepatitis B_Homo sapiens_hsa051610.14849000
138Pathways in cancer_Homo sapiens_hsa052000.13164088
139Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12515804
140Pyruvate metabolism_Homo sapiens_hsa006200.12441907
141AMPK signaling pathway_Homo sapiens_hsa041520.11605216
142Thyroid hormone signaling pathway_Homo sapiens_hsa049190.11508486
143Arginine and proline metabolism_Homo sapiens_hsa003300.11209409
144Vitamin digestion and absorption_Homo sapiens_hsa049770.10744787
145FoxO signaling pathway_Homo sapiens_hsa040680.09319450
146Pentose and glucuronate interconversions_Homo sapiens_hsa000400.06795570
147Wnt signaling pathway_Homo sapiens_hsa043100.05845415
148Adherens junction_Homo sapiens_hsa045200.05192517

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