NGB

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an oxygen-binding protein that is distantly related to members of the globin gene family. It is highly conserved among other vertebrates. It is expressed in the central and peripheral nervous system where it may be involved in increasing oxygen availability and providing protection under hypoxic/ischemic conditions. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)9.16365381
2membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.82523558
3eosinophil chemotaxis (GO:0048245)5.66061936
4cellular potassium ion homeostasis (GO:0030007)5.54745495
5sodium ion export (GO:0071436)5.11290358
6regulation of short-term neuronal synaptic plasticity (GO:0048172)5.09674603
7L-amino acid import (GO:0043092)4.99110025
8eosinophil migration (GO:0072677)4.99101657
9neurotransmitter catabolic process (GO:0042135)4.88603092
10synaptic vesicle maturation (GO:0016188)4.82537669
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.72496043
12regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.68624063
13neuron cell-cell adhesion (GO:0007158)4.65919513
14positive regulation of synapse maturation (GO:0090129)4.64189955
15positive regulation of dendritic spine development (GO:0060999)4.60169796
16vocalization behavior (GO:0071625)4.52061570
17neurotransmitter secretion (GO:0007269)4.51970712
18negative regulation of amyloid precursor protein catabolic process (GO:1902992)4.48200495
19regulation of voltage-gated calcium channel activity (GO:1901385)4.39626691
20synaptic vesicle exocytosis (GO:0016079)4.38060048
21amino acid import (GO:0043090)4.37471327
22negative regulation of dendrite morphogenesis (GO:0050774)4.37195444
23regulation of synapse structural plasticity (GO:0051823)4.28425454
24regulation of synaptic vesicle exocytosis (GO:2000300)4.24234609
25neurotransmitter-gated ion channel clustering (GO:0072578)4.23821938
26protein localization to synapse (GO:0035418)4.19596879
27regulation of synaptic plasticity (GO:0048167)4.18698878
28proline transport (GO:0015824)4.18101558
29phenol-containing compound catabolic process (GO:0019336)4.17201930
30cerebellar granule cell differentiation (GO:0021707)4.16739780
31positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.15430760
32dendritic spine morphogenesis (GO:0060997)4.14789702
33neuronal ion channel clustering (GO:0045161)4.13987872
34positive regulation of membrane potential (GO:0045838)4.08658801
35positive regulation of dendritic spine morphogenesis (GO:0061003)4.06919701
36neuromuscular process controlling posture (GO:0050884)4.06504026
37positive regulation of neurotransmitter secretion (GO:0001956)4.05757820
38positive regulation of neurotransmitter transport (GO:0051590)4.05667611
39regulation of excitatory postsynaptic membrane potential (GO:0060079)4.03845414
40regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.03235421
41negative regulation of synaptic transmission, GABAergic (GO:0032229)4.02799021
42cerebellar Purkinje cell differentiation (GO:0021702)4.01820571
43neurotransmitter transport (GO:0006836)3.99463292
44positive regulation of synaptic transmission, GABAergic (GO:0032230)3.96528821
45positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.94857253
46cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.94359933
47potassium ion homeostasis (GO:0055075)3.93332460
48regulation of glutamate secretion (GO:0014048)3.90606910
49synaptic vesicle endocytosis (GO:0048488)3.89991580
50neuromuscular process controlling balance (GO:0050885)3.89131862
51regulation of ARF protein signal transduction (GO:0032012)3.87936145
52regulation of glutamate receptor signaling pathway (GO:1900449)3.87511452
53axon ensheathment in central nervous system (GO:0032291)3.86761918
54central nervous system myelination (GO:0022010)3.86761918
55neuron recognition (GO:0008038)3.85312837
56regulation of dendritic spine morphogenesis (GO:0061001)3.81091271
57glutamate secretion (GO:0014047)3.80723281
58activation of protein kinase A activity (GO:0034199)3.79850208
59regulation of postsynaptic membrane potential (GO:0060078)3.74625618
60regulation of dendritic spine development (GO:0060998)3.72597052
61mating behavior (GO:0007617)3.72274275
62catecholamine transport (GO:0051937)3.70534653
63regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.69971768
64regulation of amyloid precursor protein catabolic process (GO:1902991)3.69943003
65regulation of protein kinase A signaling (GO:0010738)3.65276567
66G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.65241881
67regulation of synapse maturation (GO:0090128)3.63542791
68locomotory exploration behavior (GO:0035641)3.61417169
69dendritic spine organization (GO:0097061)3.60781773
70regulation of synaptic vesicle transport (GO:1902803)3.60458131
71respiratory system process (GO:0003016)3.60349250
72potassium ion import (GO:0010107)3.60240936
73regulation of neurotransmitter levels (GO:0001505)3.58950933
74regulation of transmission of nerve impulse (GO:0051969)3.48009578
75transmission of nerve impulse (GO:0019226)3.47584168
76long-term memory (GO:0007616)3.45622504
77cell communication by electrical coupling (GO:0010644)3.44032663
78gamma-aminobutyric acid signaling pathway (GO:0007214)3.42344420
79ionotropic glutamate receptor signaling pathway (GO:0035235)3.41939961
80positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.39074284
81acidic amino acid transport (GO:0015800)3.37311124
82mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.36837189
83regulation of synaptic transmission (GO:0050804)3.33659281
84regulation of vesicle fusion (GO:0031338)3.32790016
85gamma-aminobutyric acid transport (GO:0015812)3.32304425
86membrane depolarization (GO:0051899)3.30385928
87axonal fasciculation (GO:0007413)3.30095215
88cellular sodium ion homeostasis (GO:0006883)3.23390897
89vesicle docking involved in exocytosis (GO:0006904)3.23219155
90positive regulation of amine transport (GO:0051954)3.22047706
91phosphorelay signal transduction system (GO:0000160)3.20376960
92negative regulation of amino acid transport (GO:0051956)3.19435800
93ATP hydrolysis coupled proton transport (GO:0015991)3.18501607
94energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.18501607
95regulation of exocytosis (GO:0017157)3.18426329
96membrane depolarization during action potential (GO:0086010)3.16940702
97regulation of beta-amyloid formation (GO:1902003)3.16328908
98neurotransmitter uptake (GO:0001504)3.15846807
99establishment of synaptic vesicle localization (GO:0097480)3.15844085
100synaptic vesicle transport (GO:0048489)3.15844085
101neuronal action potential propagation (GO:0019227)3.15652848
102layer formation in cerebral cortex (GO:0021819)3.15038689
103exploration behavior (GO:0035640)3.13425933
104behavioral response to ethanol (GO:0048149)3.13303226
105mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.12689140
106maternal behavior (GO:0042711)3.11871688
107positive regulation of amino acid transport (GO:0051957)3.11862793
108neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.10216075
109detection of calcium ion (GO:0005513)3.10134912
110dopamine receptor signaling pathway (GO:0007212)3.09413407
111vesicle transport along microtubule (GO:0047496)3.09407907
112positive regulation of synapse assembly (GO:0051965)3.09282420
113glycine transport (GO:0015816)3.09205412
114auditory behavior (GO:0031223)3.08286904
115glutamate receptor signaling pathway (GO:0007215)3.07564500
116long-term synaptic potentiation (GO:0060291)3.06345054
117positive regulation of dendrite development (GO:1900006)3.05526303
118L-glutamate transport (GO:0015813)3.05166168
119establishment of protein localization to mitochondrial membrane (GO:0090151)3.04694880
120regulation of neurotransmitter secretion (GO:0046928)3.04515589
121behavioral response to nicotine (GO:0035095)3.04465629
122positive regulation of potassium ion transmembrane transport (GO:1901381)3.02689519
123dicarboxylic acid transport (GO:0006835)3.02554515
124regulation of neuronal synaptic plasticity (GO:0048168)3.00489195
125acid secretion (GO:0046717)2.99920246
126female mating behavior (GO:0060180)2.98890968
127cytoskeletal anchoring at plasma membrane (GO:0007016)2.98810338
128regulation of cAMP-dependent protein kinase activity (GO:2000479)2.97572512
129regulation of neurotransmitter transport (GO:0051588)2.96672544
130neuromuscular synaptic transmission (GO:0007274)2.96409236
131postsynaptic membrane organization (GO:0001941)2.96250877
132intraspecies interaction between organisms (GO:0051703)2.95325168
133social behavior (GO:0035176)2.95325168
134response to histamine (GO:0034776)2.91352349
135energy coupled proton transport, down electrochemical gradient (GO:0015985)2.90330141
136ATP synthesis coupled proton transport (GO:0015986)2.90330141
137synapse assembly (GO:0007416)2.89125238
138neuron-neuron synaptic transmission (GO:0007270)2.86251693
139negative regulation of microtubule polymerization (GO:0031115)2.86170010
140synaptic transmission, glutamatergic (GO:0035249)2.85604260
141cell migration in hindbrain (GO:0021535)2.85173002
142transferrin transport (GO:0033572)2.84610899
143regulation of female receptivity (GO:0045924)2.83846364
144synaptic transmission (GO:0007268)2.83199203
145ERK1 and ERK2 cascade (GO:0070371)2.83105045
146presynaptic membrane assembly (GO:0097105)2.82714103
147suckling behavior (GO:0001967)2.82661447
148positive regulation of catecholamine secretion (GO:0033605)2.81417378
149multi-organism reproductive behavior (GO:0044705)2.78913669
150neuropeptide signaling pathway (GO:0007218)2.77360923
151positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.74239075
152opioid receptor signaling pathway (GO:0038003)2.74233247
153regulation of long-term neuronal synaptic plasticity (GO:0048169)2.74032476
154positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-2.73738919
155electron transport chain (GO:0022900)2.73405393
156synaptic transmission, cholinergic (GO:0007271)2.73329729
157chaperone-mediated protein transport (GO:0072321)2.72006104
158regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.71071707
159calcium-mediated signaling using intracellular calcium source (GO:0035584)2.69299305

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.06623521
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.38162456
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.22062605
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.20204285
5GBX2_23144817_ChIP-Seq_PC3_Human2.87473232
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.82261333
7* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.71071016
8CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.65079859
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.63930972
10* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.62526297
11THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.62291137
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.61934843
13REST_21632747_ChIP-Seq_MESCs_Mouse2.60647104
14* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.59773595
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59484288
16* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.57671812
17EZH2_18974828_ChIP-Seq_MESCs_Mouse2.53360777
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.53360777
19TAF15_26573619_Chip-Seq_HEK293_Human2.45314260
20EED_16625203_ChIP-ChIP_MESCs_Mouse2.42216577
21RCOR2_21632747_ChIP-Seq_MESCs_Mouse2.38542464
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.19647420
23REST_18959480_ChIP-ChIP_MESCs_Mouse2.17835679
24* EZH2_27294783_Chip-Seq_ESCs_Mouse2.12907393
25BMI1_23680149_ChIP-Seq_NPCS_Mouse2.03099193
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.01444723
27RNF2_27304074_Chip-Seq_ESCs_Mouse2.00952839
28NR3C1_23031785_ChIP-Seq_PC12_Mouse1.95029242
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.91996842
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.89558657
31SMAD_19615063_ChIP-ChIP_OVARY_Human1.84243931
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.80643887
33ZFP57_27257070_Chip-Seq_ESCs_Mouse1.80317539
34ERG_21242973_ChIP-ChIP_JURKAT_Human1.78237119
35RARB_27405468_Chip-Seq_BRAIN_Mouse1.76741130
36CTBP1_25329375_ChIP-Seq_LNCAP_Human1.75299502
37KDM2B_26808549_Chip-Seq_K562_Human1.72984611
38DROSHA_22980978_ChIP-Seq_HELA_Human1.72420092
39MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.65756856
40SMAD4_21799915_ChIP-Seq_A2780_Human1.65247683
41TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61906928
42ZNF274_21170338_ChIP-Seq_K562_Hela1.59575298
43AR_21572438_ChIP-Seq_LNCaP_Human1.56191711
44IGF1R_20145208_ChIP-Seq_DFB_Human1.54147986
45P300_19829295_ChIP-Seq_ESCs_Human1.53415324
46EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.51824149
47* CTCF_27219007_Chip-Seq_Bcells_Human1.48411107
48PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47488108
49RNF2_27304074_Chip-Seq_NSC_Mouse1.41748015
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.40980313
51CDX2_19796622_ChIP-Seq_MESCs_Mouse1.39882540
52ESR1_15608294_ChIP-ChIP_MCF-7_Human1.39122839
53CBX2_27304074_Chip-Seq_ESCs_Mouse1.38513795
54* TET1_21490601_ChIP-Seq_MESCs_Mouse1.35013519
55ZFP281_27345836_Chip-Seq_ESCs_Mouse1.34114197
56JUN_21703547_ChIP-Seq_K562_Human1.28167916
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.26970777
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.26165002
59LXR_22292898_ChIP-Seq_THP-1_Human1.25409491
60SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.24979384
61TOP2B_26459242_ChIP-Seq_MCF-7_Human1.24794841
62ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.24688667
63SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24179564
64WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.24168313
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.23077208
66RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22693837
67SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22500975
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.22350562
69SOX2_21211035_ChIP-Seq_LN229_Gbm1.21579862
70AR_25329375_ChIP-Seq_VCAP_Human1.21543981
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.21071126
72RING1B_27294783_Chip-Seq_ESCs_Mouse1.20791148
73FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.19670810
74OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.19452708
75* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.19038333
76SMAD3_21741376_ChIP-Seq_EPCs_Human1.18151962
77OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.15093615
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14862718
79SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.12519436
80OCT4_19829295_ChIP-Seq_ESCs_Human1.10292175
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08755547
82KDM2B_26808549_Chip-Seq_SUP-B15_Human1.08120927
83ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.07760795
84FUS_26573619_Chip-Seq_HEK293_Human1.07421657
85SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.05788208
86ESR2_21235772_ChIP-Seq_MCF-7_Human1.05061707
87SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.04860347
88EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04676614
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04510730
90GATA1_26923725_Chip-Seq_HPCs_Mouse1.04230049
91GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.04105415
92PIAS1_25552417_ChIP-Seq_VCAP_Human1.02115875
93TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01446646
94CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.01137408
95SMC4_20622854_ChIP-Seq_HELA_Human0.99516758
96RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98998592
97PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.98043826
98TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97647687
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.97647687
100KLF4_19829295_ChIP-Seq_ESCs_Human0.97468955
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.97316046
102DPY_21335234_ChIP-Seq_ESCs_Mouse0.96948177
103SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96857360
104AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.96830909
105STAT3_23295773_ChIP-Seq_U87_Human0.96506428
106GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.95867154
107POU3F2_20337985_ChIP-ChIP_501MEL_Human0.95682450
108RUNX2_22187159_ChIP-Seq_PCA_Human0.95263702
109EP300_21415370_ChIP-Seq_HL-1_Mouse0.93953864
110AHR_22903824_ChIP-Seq_MCF-7_Human0.93495565
111HTT_18923047_ChIP-ChIP_STHdh_Human0.92889349
112P68_20966046_ChIP-Seq_HELA_Human0.90823808
113WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89100495
114MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88834813
115FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.88694763
116P53_22127205_ChIP-Seq_FIBROBLAST_Human0.88443498
117TP53_20018659_ChIP-ChIP_R1E_Mouse0.88354293
118RING1B_27294783_Chip-Seq_NPCs_Mouse0.87668551
119AR_19668381_ChIP-Seq_PC3_Human0.85777545
120TP53_18474530_ChIP-ChIP_U2OS_Human0.85754582
121SMAD4_21741376_ChIP-Seq_HESCs_Human0.85197389
122TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85053637
123YAP1_20516196_ChIP-Seq_MESCs_Mouse0.84971745
124ARNT_22903824_ChIP-Seq_MCF-7_Human0.84965448
125EGR1_19032775_ChIP-ChIP_M12_Human0.83913972
126ER_23166858_ChIP-Seq_MCF-7_Human0.83817550
127CBP_20019798_ChIP-Seq_JUKART_Human0.83132586
128IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83132586
129CREB1_26743006_Chip-Seq_LNCaP_Human0.82944869
130SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82814043
131TCF4_23295773_ChIP-Seq_U87_Human0.82656074
132PRDM14_20953172_ChIP-Seq_ESCs_Human0.82612113
133VDR_22108803_ChIP-Seq_LS180_Human0.82381880
134ZFP281_18757296_ChIP-ChIP_E14_Mouse0.80170928
135SMAD3_21741376_ChIP-Seq_ESCs_Human0.80150052
136REST_19997604_ChIP-ChIP_NEURONS_Mouse0.79699526
137SMAD4_21741376_ChIP-Seq_ESCs_Human0.78933827
138* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.78856012
139PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.77299604
140TET1_21451524_ChIP-Seq_MESCs_Mouse0.72548172
141SA1_27219007_Chip-Seq_Bcells_Human0.72469020
142MYC_19915707_ChIP-ChIP_AK7_Human0.71145352
143* KDM2B_26808549_Chip-Seq_DND41_Human0.70929008
144MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.70571112
145* SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.69020870
146* KDM2B_26808549_Chip-Seq_JURKAT_Human0.68883785

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.51284788
2MP0004859_abnormal_synaptic_plasticity4.13439984
3MP0006276_abnormal_autonomic_nervous3.81787221
4MP0002822_catalepsy3.63776802
5MP0003122_maternal_imprinting3.48016841
6MP0003635_abnormal_synaptic_transmissio3.40454703
7MP0009745_abnormal_behavioral_response3.22801453
8MP0001968_abnormal_touch/_nociception3.22655339
9MP0004270_analgesia2.98933425
10MP0002064_seizures2.95817171
11MP0009046_muscle_twitch2.70523605
12MP0001440_abnormal_grooming_behavior2.68027392
13MP0002734_abnormal_mechanical_nocicepti2.64462887
14MP0002063_abnormal_learning/memory/cond2.54783271
15MP0002572_abnormal_emotion/affect_behav2.52614815
16MP0001529_abnormal_vocalization2.52538592
17MP0005423_abnormal_somatic_nervous2.39269779
18MP0002736_abnormal_nociception_after2.34904097
19MP0005645_abnormal_hypothalamus_physiol2.33943833
20MP0002272_abnormal_nervous_system2.33472282
21MP0002733_abnormal_thermal_nociception2.32476894
22MP0001501_abnormal_sleep_pattern2.26976070
23MP0001905_abnormal_dopamine_level2.26130203
24MP0001970_abnormal_pain_threshold2.23453528
25MP0010386_abnormal_urinary_bladder2.06057459
26MP0002735_abnormal_chemical_nociception2.01978481
27MP0004142_abnormal_muscle_tone2.00834318
28MP0000751_myopathy1.92765797
29MP0005386_behavior/neurological_phenoty1.90099294
30MP0004924_abnormal_behavior1.90099294
31MP0004858_abnormal_nervous_system1.88629681
32MP0002067_abnormal_sensory_capabilities1.85911278
33MP0005646_abnormal_pituitary_gland1.84073487
34MP0001486_abnormal_startle_reflex1.78987744
35MP0002638_abnormal_pupillary_reflex1.75584682
36MP0002184_abnormal_innervation1.67695439
37MP0003123_paternal_imprinting1.54645700
38MP0003787_abnormal_imprinting1.53039145
39MP0002876_abnormal_thyroid_physiology1.52263215
40MP0003329_amyloid_beta_deposits1.47512532
41MP0002557_abnormal_social/conspecific_i1.44935254
42MP0008569_lethality_at_weaning1.42086921
43MP0000778_abnormal_nervous_system1.41585063
44MP0003121_genomic_imprinting1.39856710
45MP0000955_abnormal_spinal_cord1.31971658
46MP0002066_abnormal_motor_capabilities/c1.31872512
47MP0001177_atelectasis1.31437688
48MP0002909_abnormal_adrenal_gland1.29545021
49MP0004811_abnormal_neuron_physiology1.29040017
50MP0001502_abnormal_circadian_rhythm1.28159493
51MP0008872_abnormal_physiological_respon1.26772651
52MP0003633_abnormal_nervous_system1.23504124
53MP0004510_myositis1.20458459
54MP0001984_abnormal_olfaction1.19671445
55MP0003075_altered_response_to1.18385520
56MP0002837_dystrophic_cardiac_calcinosis1.18256813
57MP0002882_abnormal_neuron_morphology1.17138404
58MP0006072_abnormal_retinal_apoptosis1.10350245
59MP0005379_endocrine/exocrine_gland_phen1.08337986
60MP0000013_abnormal_adipose_tissue1.05148282
61MP0002163_abnormal_gland_morphology1.04611554
62MP0003631_nervous_system_phenotype1.02247705
63MP0002332_abnormal_exercise_endurance0.99215270
64MP0000538_abnormal_urinary_bladder0.99198010
65MP0001485_abnormal_pinna_reflex0.97792110
66MP0005167_abnormal_blood-brain_barrier0.96594852
67MP0002069_abnormal_eating/drinking_beha0.94789281
68MP0008961_abnormal_basal_metabolism0.92834836
69MP0002229_neurodegeneration0.91618179
70MP0005535_abnormal_body_temperature0.91261564
71MP0005499_abnormal_olfactory_system0.90932275
72MP0005394_taste/olfaction_phenotype0.90932275
73MP0005623_abnormal_meninges_morphology0.89126456
74MP0003183_abnormal_peptide_metabolism0.88726127
75MP0005551_abnormal_eye_electrophysiolog0.88002845
76MP0004885_abnormal_endolymph0.87773548
77MP0009780_abnormal_chondrocyte_physiolo0.86568371
78MP0008877_abnormal_DNA_methylation0.85969659
79MP0002751_abnormal_autonomic_nervous0.85292788
80MP0002152_abnormal_brain_morphology0.83761624
81MP0003690_abnormal_glial_cell0.81934257
82MP0000747_muscle_weakness0.80532553
83MP0003634_abnormal_glial_cell0.80215823
84MP0000631_abnormal_neuroendocrine_gland0.80116134
85MP0004147_increased_porphyrin_level0.78620573
86MP0002090_abnormal_vision0.75743758
87MP0002254_reproductive_system_inflammat0.75053819
88MP0003137_abnormal_impulse_conducting0.74302983
89MP0008789_abnormal_olfactory_epithelium0.74296009
90MP0002752_abnormal_somatic_nervous0.73451496
91MP0000579_abnormal_nail_morphology0.71926384
92MP0004130_abnormal_muscle_cell0.71356792
93MP0000639_abnormal_adrenal_gland0.70830724
94MP0000920_abnormal_myelination0.70752076
95MP0001963_abnormal_hearing_physiology0.69594043
96MP0008874_decreased_physiological_sensi0.69432052
97MP0001188_hyperpigmentation0.69386772
98MP0003283_abnormal_digestive_organ0.68947973
99MP0004145_abnormal_muscle_electrophysio0.68711078
100MP0004085_abnormal_heartbeat0.67361357
101MP0001299_abnormal_eye_distance/0.66930707
102MP0000604_amyloidosis0.64554420
103MP0005448_abnormal_energy_balance0.62831354
104MP0004742_abnormal_vestibular_system0.62005959
105MP0001986_abnormal_taste_sensitivity0.60660349
106MP0009379_abnormal_foot_pigmentation0.60268347
107MP0005166_decreased_susceptibility_to0.60099481
108MP0001348_abnormal_lacrimal_gland0.59669771
109MP0001346_abnormal_lacrimal_gland0.59407099
110MP0003879_abnormal_hair_cell0.58955527
111MP0003632_abnormal_nervous_system0.58927888
112MP0001943_abnormal_respiration0.58103226
113MP0005253_abnormal_eye_physiology0.57354010
114MP0000026_abnormal_inner_ear0.53065392
115MP0010769_abnormal_survival0.52868055
116MP0003956_abnormal_body_size0.49911040
117MP0010768_mortality/aging0.49526523
118MP0000566_synostosis0.49335870
119MP0002082_postnatal_lethality0.49106731
120MP0010770_preweaning_lethality0.49106731
121MP0002873_normal_phenotype0.48578259
122MP0003938_abnormal_ear_development0.47472090
123MP0003861_abnormal_nervous_system0.47426154
124MP0002169_no_abnormal_phenotype0.47301676
125MP0003172_abnormal_lysosome_physiology0.43290727

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.20547967
2Focal motor seizures (HP:0011153)6.02874110
3Diplopia (HP:0000651)5.23942035
4Abnormality of binocular vision (HP:0011514)5.23942035
5Hypothermia (HP:0002045)5.09363498
6Polyphagia (HP:0002591)4.71112618
7Focal seizures (HP:0007359)4.50522222
8Atonic seizures (HP:0010819)4.38312270
9Visual hallucinations (HP:0002367)4.33434910
10Absence seizures (HP:0002121)4.05022757
11Abnormal eating behavior (HP:0100738)3.91858492
12Failure to thrive in infancy (HP:0001531)3.70645726
13Limb dystonia (HP:0002451)3.68203724
14Annular pancreas (HP:0001734)3.59237688
15Epileptic encephalopathy (HP:0200134)3.59142706
16Generalized tonic-clonic seizures (HP:0002069)3.46593758
17Dialeptic seizures (HP:0011146)3.45447161
18Intention tremor (HP:0002080)3.45420457
19Abnormal hair whorl (HP:0010721)3.45144660
20Febrile seizures (HP:0002373)3.40175937
21Cerebral hypomyelination (HP:0006808)3.34929868
22Supranuclear gaze palsy (HP:0000605)3.27002247
23Tetraplegia (HP:0002445)3.25706868
24Status epilepticus (HP:0002133)3.08510433
25Progressive cerebellar ataxia (HP:0002073)3.07900093
26Hypoventilation (HP:0002791)3.04604343
27Obstructive sleep apnea (HP:0002870)3.00380200
28Anxiety (HP:0000739)2.97801784
29Hemiplegia (HP:0002301)2.95742618
30Pheochromocytoma (HP:0002666)2.94549110
31Clonus (HP:0002169)2.94255796
32Amblyopia (HP:0000646)2.92755037
33Apathy (HP:0000741)2.88611093
34Acute necrotizing encephalopathy (HP:0006965)2.86520029
35Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.85768914
36Oligomenorrhea (HP:0000876)2.81988104
37Gait imbalance (HP:0002141)2.79375347
38Bradykinesia (HP:0002067)2.79365312
39Poor suck (HP:0002033)2.74597944
40Esotropia (HP:0000565)2.70865414
41Abnormality of the corticospinal tract (HP:0002492)2.69277111
42Akinesia (HP:0002304)2.66865995
43Abnormal mitochondria in muscle tissue (HP:0008316)2.66219958
44Neurofibrillary tangles (HP:0002185)2.65658389
45Neuroendocrine neoplasm (HP:0100634)2.63612953
46Impaired vibration sensation in the lower limbs (HP:0002166)2.62472212
47Progressive macrocephaly (HP:0004481)2.60824490
48Progressive inability to walk (HP:0002505)2.60784405
49Bundle branch block (HP:0011710)2.60002513
50Abnormality of the labia minora (HP:0012880)2.59725023
51Nephrogenic diabetes insipidus (HP:0009806)2.59348136
52Diminished motivation (HP:0000745)2.57318489
53Impaired vibratory sensation (HP:0002495)2.54078425
54Diaphragmatic weakness (HP:0009113)2.51589671
55Impaired social interactions (HP:0000735)2.48452884
56Abnormal social behavior (HP:0012433)2.48452884
57Growth hormone excess (HP:0000845)2.48359671
58Psychosis (HP:0000709)2.47302615
59Depression (HP:0000716)2.46687886
60Papilledema (HP:0001085)2.46559882
61Action tremor (HP:0002345)2.45449925
62Ankle clonus (HP:0011448)2.44353690
63Congenital primary aphakia (HP:0007707)2.42852276
64Mutism (HP:0002300)2.40873559
65Ventricular fibrillation (HP:0001663)2.40437278
66Broad-based gait (HP:0002136)2.38359218
67Cerebral inclusion bodies (HP:0100314)2.38280144
68Hyperthyroidism (HP:0000836)2.38172446
69Rigidity (HP:0002063)2.37736466
70Mitochondrial inheritance (HP:0001427)2.37237370
71Abnormality of pain sensation (HP:0010832)2.36503483
72Impaired pain sensation (HP:0007328)2.36503483
73Asthma (HP:0002099)2.33324959
74Insomnia (HP:0100785)2.32951349
75Abnormal autonomic nervous system physiology (HP:0012332)2.31026401
76Spastic gait (HP:0002064)2.31006040
77Menstrual irregularities (HP:0000858)2.28874087
78Dysmetria (HP:0001310)2.28723863
79Choreoathetosis (HP:0001266)2.28475285
80Sleep apnea (HP:0010535)2.26877624
81Urinary bladder sphincter dysfunction (HP:0002839)2.24590998
82Agitation (HP:0000713)2.23761324
83Acute encephalopathy (HP:0006846)2.21783944
84Impaired smooth pursuit (HP:0007772)2.19563364
85Incomplete penetrance (HP:0003829)2.19312907
86Stereotypic behavior (HP:0000733)2.18886835
87Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.18230403
88Degeneration of the lateral corticospinal tracts (HP:0002314)2.18230403
89Torticollis (HP:0000473)2.17813958
90Specific learning disability (HP:0001328)2.16224646
91Orthostatic hypotension (HP:0001278)2.15259105
92Heart block (HP:0012722)2.14373303
93Delusions (HP:0000746)2.10024384
94Megalencephaly (HP:0001355)2.09991259
95Genital tract atresia (HP:0001827)2.08210956
96Spastic tetraparesis (HP:0001285)2.06192351
97Split foot (HP:0001839)2.04938642
98Abnormal pupillary function (HP:0007686)2.04650282
99Exercise-induced myalgia (HP:0003738)2.03554101
100EEG with generalized epileptiform discharges (HP:0011198)2.02503050
101Anosmia (HP:0000458)2.02116688
102Narrow nasal bridge (HP:0000446)2.01770931
103Epileptiform EEG discharges (HP:0011182)2.01754626
104Lower limb muscle weakness (HP:0007340)2.01438703
105Termporal pattern (HP:0011008)2.00536578
106Insidious onset (HP:0003587)2.00536578
107CNS hypomyelination (HP:0003429)1.99398433
108Rapidly progressive (HP:0003678)1.99363974
109Postural tremor (HP:0002174)1.99106213
110Myotonia (HP:0002486)1.98853543
111Abnormality of ocular smooth pursuit (HP:0000617)1.98757714
112Vaginal atresia (HP:0000148)1.98475142
113Scanning speech (HP:0002168)1.97833658
114Medial flaring of the eyebrow (HP:0010747)1.97700303
115Abnormality of the lower motor neuron (HP:0002366)1.97097726
116Hypsarrhythmia (HP:0002521)1.96379427
117Exotropia (HP:0000577)1.96015058
118Focal dystonia (HP:0004373)1.95236985
119Truncal ataxia (HP:0002078)1.94752998
120Abnormality of calcium-phosphate metabolism (HP:0100530)1.94691016
121Hypercortisolism (HP:0001578)1.93783581
122Dementia (HP:0000726)1.93688808
123Abnormality of saccadic eye movements (HP:0000570)1.93659297
124Increased circulating renin level (HP:0000848)1.92330833
125Abnormal atrioventricular conduction (HP:0005150)1.92265217
126Craniofacial dystonia (HP:0012179)1.92022200
127Poor coordination (HP:0002370)1.91774514
128Peripheral hypomyelination (HP:0007182)1.89522524
129Leukodystrophy (HP:0002415)1.88879836
130Morphological abnormality of the pyramidal tract (HP:0002062)1.88504675
131Lower limb asymmetry (HP:0100559)1.87156636
132Spinal canal stenosis (HP:0003416)1.86679559
133Postural instability (HP:0002172)1.86332387
134Neuronal loss in central nervous system (HP:0002529)1.85819797
135Urinary urgency (HP:0000012)1.85186997
136Slow saccadic eye movements (HP:0000514)1.84593048
137Poor eye contact (HP:0000817)1.83948242
138Aplasia involving bones of the extremities (HP:0009825)1.82999729
139Aplasia involving bones of the upper limbs (HP:0009823)1.82999729
140Aplasia of the phalanges of the hand (HP:0009802)1.82999729
141Hemiparesis (HP:0001269)1.82829521
142Dysdiadochokinesis (HP:0002075)1.82791638
143Memory impairment (HP:0002354)1.81355697
144Cerebral hemorrhage (HP:0001342)1.79136682
145Thickened helices (HP:0000391)1.75618675
146Abnormal EKG (HP:0003115)1.74434662
147Fetal akinesia sequence (HP:0001989)1.74027445
148Lower limb amyotrophy (HP:0007210)1.74013892
149Gaze-evoked nystagmus (HP:0000640)1.71806344

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.79635936
2NTRK34.39701552
3MAP3K93.91740694
4NTRK13.26361502
5ARAF3.13488930
6MINK12.57588844
7MAP3K42.49652053
8MARK12.43962978
9NTRK22.37343966
10MAP2K42.35998614
11GRK52.09226103
12PNCK1.99983122
13MAP2K71.96989921
14GRK71.92016139
15KSR21.90114830
16NME11.68314206
17CASK1.67113137
18TNIK1.66818870
19PHKG11.59561116
20PHKG21.59561116
21UHMK11.50689522
22EPHA41.50043846
23MAP3K131.48863776
24TNK21.44869653
25MAPK131.35712811
26PINK11.34894535
27CDK51.21347013
28PAK61.20734114
29PRKCG1.19385514
30DAPK21.19327853
31CDK191.18735614
32STK391.13877399
33PLK21.12798628
34OXSR11.11195379
35CAMK2B1.05187366
36NEK61.03606201
37CAMK2A1.02544727
38CDK141.01633564
39ALK1.00760000
40MARK21.00370415
41LATS21.00070980
42CAMK2G0.97731891
43CDK180.96654044
44CSNK1G20.96213706
45CDK150.96099249
46MAP3K10.95872372
47PAK30.94456256
48CAMKK20.93909027
49BRSK10.91953154
50MAPK120.91667784
51SGK4940.90979257
52SGK2230.90979257
53MYLK0.90793148
54CAMKK10.90356554
55BMPR20.88062691
56LMTK20.87959687
57CSNK1G30.87697832
58ADRBK10.86634806
59WNK40.86619729
60RIPK10.86578973
61FES0.85386529
62DYRK1A0.84529104
63TAOK20.82408626
64CAMK2D0.81289638
65CDK11A0.80933081
66TSSK60.79535395
67SIK20.78938452
68MAP3K20.76423823
69SGK30.76184115
70MAP3K110.75864380
71CAMK1G0.75844303
72KSR10.72896545
73PKN10.72579416
74MAPKAPK50.72135518
75PRKCE0.71704693
76DAPK30.70389620
77DAPK10.69374698
78ADRBK20.68042657
79RAF10.65907249
80MAPK100.65162951
81BCR0.62181126
82MAP2K10.60915142
83BRAF0.59881801
84PDK10.59459181
85CAMK10.59179662
86MOS0.58717197
87RIPK40.58175209
88MATK0.55863453
89RPS6KA20.54444858
90CSNK1G10.54401019
91LIMK10.54242954
92PRKG20.53856585
93PRKCH0.53538029
94STK110.52627505
95TYRO30.51779676
96CAMK40.51153638
97SGK20.50769532
98PDPK10.50613204
99WNK10.49617603
100TESK10.48440072
101SIK30.48439217
102IRAK20.48422449
103PRKD30.46682055
104FER0.45878043
105AKT30.42590203
106SCYL20.39485850
107PRPF4B0.36745077
108MAP2K60.35900658
109WNK30.35871238
110PRKCZ0.35225578
111CAMK1D0.35104520
112PRKACA0.35083845
113RPS6KA30.34535043
114SGK10.34462437
115FYN0.33830526
116ERBB20.32831569
117CCNB10.32550384
118PRKCB0.31855261
119ROCK20.31813724
120STK380.31424960
121PRKCA0.31219363
122MAPK80.26127711
123ROCK10.22949446
124MAPK40.21571241
125PTK2B0.20545619

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.66583638
2Synaptic vesicle cycle_Homo sapiens_hsa047213.56308505
3GABAergic synapse_Homo sapiens_hsa047272.83391881
4Oxidative phosphorylation_Homo sapiens_hsa001902.74520015
5Collecting duct acid secretion_Homo sapiens_hsa049662.55751911
6Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.46785370
7Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.45500363
8Parkinsons disease_Homo sapiens_hsa050122.33280709
9Olfactory transduction_Homo sapiens_hsa047402.27983167
10Asthma_Homo sapiens_hsa053102.27665359
11Cocaine addiction_Homo sapiens_hsa050302.25603006
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.23176001
13Morphine addiction_Homo sapiens_hsa050322.22748917
14Circadian entrainment_Homo sapiens_hsa047132.18927259
15Amphetamine addiction_Homo sapiens_hsa050312.16907496
16Serotonergic synapse_Homo sapiens_hsa047261.97961229
17Dopaminergic synapse_Homo sapiens_hsa047281.97383256
18Glutamatergic synapse_Homo sapiens_hsa047241.94997267
19Long-term potentiation_Homo sapiens_hsa047201.92947512
20Vitamin B6 metabolism_Homo sapiens_hsa007501.92767720
21Alzheimers disease_Homo sapiens_hsa050101.79280115
22Vibrio cholerae infection_Homo sapiens_hsa051101.76923514
23Cardiac muscle contraction_Homo sapiens_hsa042601.74041474
24Insulin secretion_Homo sapiens_hsa049111.71992803
25Cholinergic synapse_Homo sapiens_hsa047251.71348355
26Renin secretion_Homo sapiens_hsa049241.67283354
27Taste transduction_Homo sapiens_hsa047421.66735222
28Salivary secretion_Homo sapiens_hsa049701.62786258
29Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.59540232
30Gastric acid secretion_Homo sapiens_hsa049711.53414488
31Huntingtons disease_Homo sapiens_hsa050161.52138429
32Long-term depression_Homo sapiens_hsa047301.51305143
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.42933770
34Sulfur metabolism_Homo sapiens_hsa009201.34116764
35Gap junction_Homo sapiens_hsa045401.33770164
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24161766
37Calcium signaling pathway_Homo sapiens_hsa040201.19535927
38Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.19111111
39Oxytocin signaling pathway_Homo sapiens_hsa049211.18230435
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.16018994
41GnRH signaling pathway_Homo sapiens_hsa049121.15326535
42Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.10867417
43Estrogen signaling pathway_Homo sapiens_hsa049151.00621558
44Phenylalanine metabolism_Homo sapiens_hsa003600.99251202
45Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.94381492
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91540410
47Tyrosine metabolism_Homo sapiens_hsa003500.91393433
48Melanogenesis_Homo sapiens_hsa049160.88502787
49Prion diseases_Homo sapiens_hsa050200.82856462
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.82160266
51Axon guidance_Homo sapiens_hsa043600.82071932
52cAMP signaling pathway_Homo sapiens_hsa040240.81256056
53Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.79041071
54Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.74355322
55Bile secretion_Homo sapiens_hsa049760.72875232
56Thyroid hormone synthesis_Homo sapiens_hsa049180.70254734
57Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69597374
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.68951227
59Rap1 signaling pathway_Homo sapiens_hsa040150.68606030
60VEGF signaling pathway_Homo sapiens_hsa043700.68181144
61Dilated cardiomyopathy_Homo sapiens_hsa054140.67224973
62Rheumatoid arthritis_Homo sapiens_hsa053230.65658601
63Phototransduction_Homo sapiens_hsa047440.63968734
64Pancreatic secretion_Homo sapiens_hsa049720.63407689
65Dorso-ventral axis formation_Homo sapiens_hsa043200.61103785
66Inositol phosphate metabolism_Homo sapiens_hsa005620.58689100
67Butanoate metabolism_Homo sapiens_hsa006500.58107114
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.57274621
69Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57212386
70Endocytosis_Homo sapiens_hsa041440.57170697
71Phagosome_Homo sapiens_hsa041450.56477661
72Oocyte meiosis_Homo sapiens_hsa041140.56297968
73Sphingolipid signaling pathway_Homo sapiens_hsa040710.55614954
74Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.55039912
75Ether lipid metabolism_Homo sapiens_hsa005650.54923711
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54867944
77Glucagon signaling pathway_Homo sapiens_hsa049220.53188364
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52507316
79Alcoholism_Homo sapiens_hsa050340.51875438
80Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.51574045
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.50268088
82Arginine and proline metabolism_Homo sapiens_hsa003300.49129204
83cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49103363
84Type I diabetes mellitus_Homo sapiens_hsa049400.48904722
85Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.48535255
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.47033448
87Arginine biosynthesis_Homo sapiens_hsa002200.46983029
88ErbB signaling pathway_Homo sapiens_hsa040120.46627180
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45591423
90Type II diabetes mellitus_Homo sapiens_hsa049300.45114585
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.45041205
92Thyroid hormone signaling pathway_Homo sapiens_hsa049190.42857022
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41961898
94MAPK signaling pathway_Homo sapiens_hsa040100.39920963
95Nitrogen metabolism_Homo sapiens_hsa009100.39515495
96Choline metabolism in cancer_Homo sapiens_hsa052310.37378631
97Ovarian steroidogenesis_Homo sapiens_hsa049130.37201425
98Fatty acid elongation_Homo sapiens_hsa000620.36029970
99Glioma_Homo sapiens_hsa052140.34571634
100Wnt signaling pathway_Homo sapiens_hsa043100.33644832
101Histidine metabolism_Homo sapiens_hsa003400.33219522
102Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32217067
103Mineral absorption_Homo sapiens_hsa049780.31842254
104Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.31435804
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.29221158
106Longevity regulating pathway - mammal_Homo sapiens_hsa042110.27282004
107Circadian rhythm_Homo sapiens_hsa047100.26743614
108Ras signaling pathway_Homo sapiens_hsa040140.26624971
109Insulin signaling pathway_Homo sapiens_hsa049100.26488877
110Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.23563450
111Pyruvate metabolism_Homo sapiens_hsa006200.23443532
112Galactose metabolism_Homo sapiens_hsa000520.23396321
113beta-Alanine metabolism_Homo sapiens_hsa004100.23376681
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.22105825
115Regulation of autophagy_Homo sapiens_hsa041400.21541570
116Neurotrophin signaling pathway_Homo sapiens_hsa047220.20458712
117Tight junction_Homo sapiens_hsa045300.19534437
118African trypanosomiasis_Homo sapiens_hsa051430.19322869
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.18938369
120Chemokine signaling pathway_Homo sapiens_hsa040620.18182678
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.16850542
122Hippo signaling pathway_Homo sapiens_hsa043900.16621171
123Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.16099986
124mTOR signaling pathway_Homo sapiens_hsa041500.15974590
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.15141949
126HIF-1 signaling pathway_Homo sapiens_hsa040660.13805688
127Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.13566416

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