NGDN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Neuroguidin is an EIF4E (MIM 133440)-binding protein that interacts with CPEB (MIM 607342) and functions as a translational regulatory protein during development of the vertebrate nervous system (Jung et al., 2006 [PubMed 16705177]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.04662305
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.00534674
3proteasome assembly (GO:0043248)4.96855992
4maturation of SSU-rRNA (GO:0030490)4.82738704
5DNA deamination (GO:0045006)4.74554971
6chaperone-mediated protein transport (GO:0072321)4.52102391
7ribosomal small subunit biogenesis (GO:0042274)4.39799851
8negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.29092637
9energy coupled proton transport, down electrochemical gradient (GO:0015985)4.26952737
10ATP synthesis coupled proton transport (GO:0015986)4.26952737
11ribosomal large subunit biogenesis (GO:0042273)4.25117922
12formation of translation preinitiation complex (GO:0001731)4.18896196
13rRNA modification (GO:0000154)4.16077821
14positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.10034696
15regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.05740933
16mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.05292422
17establishment of protein localization to mitochondrial membrane (GO:0090151)4.05082321
18anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.00716234
19ribonucleoprotein complex biogenesis (GO:0022613)3.98018397
20viral transcription (GO:0019083)3.96905617
21purine nucleobase biosynthetic process (GO:0009113)3.94028909
22protein complex biogenesis (GO:0070271)3.91867998
23negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.90702910
24negative regulation of ligase activity (GO:0051352)3.90702910
25translational termination (GO:0006415)3.90171142
26nucleobase biosynthetic process (GO:0046112)3.88715638
27DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.86580917
28respiratory chain complex IV assembly (GO:0008535)3.85661450
29mitochondrial respiratory chain complex assembly (GO:0033108)3.85093748
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.82678675
31mitochondrial respiratory chain complex I assembly (GO:0032981)3.82678675
32NADH dehydrogenase complex assembly (GO:0010257)3.82678675
33transcription elongation from RNA polymerase III promoter (GO:0006385)3.82283990
34termination of RNA polymerase III transcription (GO:0006386)3.82283990
35signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.80068352
36signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.80068352
37signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.80068352
38regulation of cellular amino acid metabolic process (GO:0006521)3.79323199
39intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.79310111
40signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.79310111
41ribosome biogenesis (GO:0042254)3.79095639
42telomere maintenance via semi-conservative replication (GO:0032201)3.76861670
43respiratory electron transport chain (GO:0022904)3.75902018
44DNA strand elongation involved in DNA replication (GO:0006271)3.72481200
45electron transport chain (GO:0022900)3.72422022
46signal transduction involved in DNA integrity checkpoint (GO:0072401)3.72388262
47signal transduction involved in DNA damage checkpoint (GO:0072422)3.72388262
48antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.71906288
49histone mRNA metabolic process (GO:0008334)3.69506250
50signal transduction involved in cell cycle checkpoint (GO:0072395)3.68328470
51mitotic metaphase plate congression (GO:0007080)3.65771504
527-methylguanosine mRNA capping (GO:0006370)3.64740062
53CENP-A containing nucleosome assembly (GO:0034080)3.64534943
54rRNA processing (GO:0006364)3.64239627
55ribosome assembly (GO:0042255)3.64072905
56positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.60342710
57regulation of mitotic spindle checkpoint (GO:1903504)3.60057654
58regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.60057654
59protein neddylation (GO:0045116)3.59528571
60translational initiation (GO:0006413)3.57713953
61DNA strand elongation (GO:0022616)3.57221493
627-methylguanosine RNA capping (GO:0009452)3.57071565
63RNA capping (GO:0036260)3.57071565
64SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.57024281
65telomere maintenance via recombination (GO:0000722)3.55435493
66translational elongation (GO:0006414)3.55168100
67antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.53164981
68cotranslational protein targeting to membrane (GO:0006613)3.51893177
69rRNA metabolic process (GO:0016072)3.49599227
70protein targeting to ER (GO:0045047)3.47514917
71DNA replication checkpoint (GO:0000076)3.47035987
72positive regulation of ligase activity (GO:0051351)3.45704032
73pseudouridine synthesis (GO:0001522)3.45561570
74termination of RNA polymerase I transcription (GO:0006363)3.44908914
75chromatin remodeling at centromere (GO:0031055)3.43492792
76translation (GO:0006412)3.43258345
77tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.41404556
78RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.41404556
79spliceosomal snRNP assembly (GO:0000387)3.40923548
80cytochrome complex assembly (GO:0017004)3.38727403
81L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.37967652
82transcription-coupled nucleotide-excision repair (GO:0006283)3.36914617
83DNA replication initiation (GO:0006270)3.36616643
84transcription from RNA polymerase I promoter (GO:0006360)3.36230938
85rRNA methylation (GO:0031167)3.35474897
86protein localization to endoplasmic reticulum (GO:0070972)3.32517357
87cellular component biogenesis (GO:0044085)3.31977814
88transcription elongation from RNA polymerase I promoter (GO:0006362)3.31398967
89regulation of mitochondrial translation (GO:0070129)3.30291961
90establishment of protein localization to endoplasmic reticulum (GO:0072599)3.28856363
91protein-cofactor linkage (GO:0018065)3.26184535
92RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.19117203
93regulation of ubiquitin-protein transferase activity (GO:0051438)3.19017652
94mitotic recombination (GO:0006312)3.18712515
95DNA double-strand break processing (GO:0000729)3.18077337
96nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.17222443
97regulation of double-strand break repair via homologous recombination (GO:0010569)3.16289559
98maturation of 5.8S rRNA (GO:0000460)3.16093825
99viral life cycle (GO:0019058)3.15815673
100mannosylation (GO:0097502)3.15506332
101DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.14799760
102protein targeting to mitochondrion (GO:0006626)3.13736809
103viral mRNA export from host cell nucleus (GO:0046784)3.12873111
104resolution of meiotic recombination intermediates (GO:0000712)3.12619494
105DNA damage response, detection of DNA damage (GO:0042769)3.12256126
106positive regulation of cell cycle arrest (GO:0071158)3.10786824
107cell cycle G1/S phase transition (GO:0044843)3.10563340
108G1/S transition of mitotic cell cycle (GO:0000082)3.10563340
109dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.09810639
110regulation of ligase activity (GO:0051340)3.08537881
111exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.07725730
112cellular protein complex disassembly (GO:0043624)3.07508286
113telomere maintenance via telomere lengthening (GO:0010833)3.07278843
114metaphase plate congression (GO:0051310)3.04403404
115transcription initiation from RNA polymerase I promoter (GO:0006361)3.03885146
116nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.03733066
117DNA replication-independent nucleosome organization (GO:0034724)3.03625385
118DNA replication-independent nucleosome assembly (GO:0006336)3.03625385
119attachment of spindle microtubules to kinetochore (GO:0008608)3.02974074
120IMP biosynthetic process (GO:0006188)3.02331680
121somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.02209154
122isotype switching (GO:0045190)3.02209154
123somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.02209154
124kinetochore assembly (GO:0051382)2.98536161
125cullin deneddylation (GO:0010388)2.98394501
126transcription elongation from RNA polymerase II promoter (GO:0006368)2.98312784
127histone exchange (GO:0043486)2.97788140
128amino acid salvage (GO:0043102)2.97750758
129L-methionine salvage (GO:0071267)2.97750758
130L-methionine biosynthetic process (GO:0071265)2.97750758
131ncRNA catabolic process (GO:0034661)2.97285750
132tRNA processing (GO:0008033)2.96802635
133peptidyl-histidine modification (GO:0018202)2.95968878
134protein localization to mitochondrion (GO:0070585)2.95907384
135rRNA catabolic process (GO:0016075)2.94751028
136protein deneddylation (GO:0000338)2.94059546
137nucleotide-excision repair, DNA gap filling (GO:0006297)2.93731981
138kinetochore organization (GO:0051383)2.93217611
139replication fork processing (GO:0031297)2.92690315
140DNA catabolic process, exonucleolytic (GO:0000738)2.91600611
141deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.91502205
142mitochondrial RNA metabolic process (GO:0000959)2.90417284
143establishment of protein localization to mitochondrion (GO:0072655)2.89916150
144regulation of helicase activity (GO:0051095)2.88410856
145DNA replication-dependent nucleosome assembly (GO:0006335)2.87956228
146DNA replication-dependent nucleosome organization (GO:0034723)2.87956228
147somatic hypermutation of immunoglobulin genes (GO:0016446)2.86605081
148somatic diversification of immune receptors via somatic mutation (GO:0002566)2.86605081
149transcription from mitochondrial promoter (GO:0006390)2.84896008
150ncRNA metabolic process (GO:0034660)2.81579288
151ncRNA processing (GO:0034470)2.80659552

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.33915618
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.10460823
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.09287550
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.86314318
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.72020683
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.69981091
7* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.43175181
8* ETS1_20019798_ChIP-Seq_JURKAT_Human3.39581068
9E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.34242312
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.19766543
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.08177659
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.95698427
13* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.79372188
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.77548011
15E2F4_17652178_ChIP-ChIP_JURKAT_Human2.76914504
16* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.73716932
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.72782473
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.66229677
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.65939902
20VDR_23849224_ChIP-Seq_CD4+_Human2.65902246
21ELF1_17652178_ChIP-ChIP_JURKAT_Human2.61482383
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.53071049
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.37925924
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.32209716
25XRN2_22483619_ChIP-Seq_HELA_Human2.27541749
26ZNF274_21170338_ChIP-Seq_K562_Hela2.25476090
27* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.24181118
28DCP1A_22483619_ChIP-Seq_HELA_Human2.23230539
29FOXP3_21729870_ChIP-Seq_TREG_Human2.23127408
30CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.16949435
31SRF_21415370_ChIP-Seq_HL-1_Mouse2.16087527
32* GABP_19822575_ChIP-Seq_HepG2_Human2.01638550
33SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.00948804
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.98532160
35ELK1_19687146_ChIP-ChIP_HELA_Human1.97066703
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89746799
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.88724278
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.87314403
39* YY1_21170310_ChIP-Seq_MESCs_Mouse1.85810130
40TTF2_22483619_ChIP-Seq_HELA_Human1.84801154
41HOXB4_20404135_ChIP-ChIP_EML_Mouse1.82272230
42EWS_26573619_Chip-Seq_HEK293_Human1.78466303
43PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.77104475
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76523603
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.72634843
46POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.69101019
47* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.66244301
48MYCN_18555785_ChIP-Seq_MESCs_Mouse1.62591897
49ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59359215
50TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59245250
51VDR_22108803_ChIP-Seq_LS180_Human1.57820657
52* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.55081430
53* HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.54150284
54AR_21909140_ChIP-Seq_LNCAP_Human1.54142695
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.51460190
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.49933235
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.45754200
58NOTCH1_21737748_ChIP-Seq_TLL_Human1.42080211
59ERG_20887958_ChIP-Seq_HPC-7_Mouse1.39884076
60CIITA_25753668_ChIP-Seq_RAJI_Human1.36913979
61SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35117006
62FUS_26573619_Chip-Seq_HEK293_Human1.33720343
63E2F1_21310950_ChIP-Seq_MCF-7_Human1.30621184
64KDM5A_27292631_Chip-Seq_BREAST_Human1.29386317
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.28426973
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.27323617
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25016871
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.24366345
69TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23659603
70BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23186190
71* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.22492887
72* ELK1_22589737_ChIP-Seq_MCF10A_Human1.21854945
73IGF1R_20145208_ChIP-Seq_DFB_Human1.20573767
74PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18590862
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.18318828
76CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18097311
77HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17450916
78POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.17417604
79TP53_22573176_ChIP-Seq_HFKS_Human1.16558352
80* SPI1_23547873_ChIP-Seq_NB4_Human1.15518252
81POU3F2_20337985_ChIP-ChIP_501MEL_Human1.14430144
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08236895
83PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07939592
84SALL1_21062744_ChIP-ChIP_HESCs_Human1.05996437
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.05937868
86TFEB_21752829_ChIP-Seq_HELA_Human1.04800719
87P300_19829295_ChIP-Seq_ESCs_Human1.01425907
88KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.01208974
89ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00774773
90ZFP57_27257070_Chip-Seq_ESCs_Mouse0.99518981
91MYC_18940864_ChIP-ChIP_HL60_Human0.99287720
92IRF8_21731497_ChIP-ChIP_J774_Mouse0.99023147
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.97996496
94TP63_19390658_ChIP-ChIP_HaCaT_Human0.97857065
95KLF4_18555785_ChIP-Seq_MESCs_Mouse0.97168805
96SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96839401
97* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95530605
98IRF1_19129219_ChIP-ChIP_H3396_Human0.94829586
99CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91708734
100SOX2_16153702_ChIP-ChIP_HESCs_Human0.91268067
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90361728
102CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89893845
103RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89638863
104CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.89027776
105IRF8_22096565_ChIP-ChIP_GC-B_Human0.88833827
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.88566902
107NANOG_16153702_ChIP-ChIP_HESCs_Human0.87885384
108CTBP1_25329375_ChIP-Seq_LNCAP_Human0.87317602
109TAF15_26573619_Chip-Seq_HEK293_Human0.85973954
110GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85198801
111CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.84667468
112MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.84620410
113SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.84257597
114NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.82397529
115GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82247391
116EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.81839976
117* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81712906
118STAT4_19710469_ChIP-ChIP_TH1__Mouse0.80512879
119CTBP2_25329375_ChIP-Seq_LNCAP_Human0.80431418
120KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79152536
121HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.79100586
122ELF5_23300383_ChIP-Seq_T47D_Human0.78876604
123SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.78094594
124* AR_20517297_ChIP-Seq_VCAP_Human0.77515528
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.76870487
126SOX2_19829295_ChIP-Seq_ESCs_Human0.76565484
127NANOG_19829295_ChIP-Seq_ESCs_Human0.76565484
128OCT4_18692474_ChIP-Seq_MEFs_Mouse0.76489888
129SOX2_18692474_ChIP-Seq_MEFs_Mouse0.76426394
130TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76190820
131FOXA1_27270436_Chip-Seq_PROSTATE_Human0.73614511
132DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.71439756

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.41837181
2MP0004957_abnormal_blastocyst_morpholog4.07032500
3MP0003111_abnormal_nucleus_morphology3.87819650
4MP0010094_abnormal_chromosome_stability3.79386137
5MP0003077_abnormal_cell_cycle3.62415168
6MP0008057_abnormal_DNA_replication3.51065719
7MP0008058_abnormal_DNA_repair3.48405697
8MP0008007_abnormal_cellular_replicative2.85531934
9MP0003718_maternal_effect2.55368409
10MP0008932_abnormal_embryonic_tissue2.42451558
11MP0002102_abnormal_ear_morphology2.39680656
12MP0003786_premature_aging2.31865338
13MP0003890_abnormal_embryonic-extraembry2.27161280
14MP0003806_abnormal_nucleotide_metabolis2.21511217
15MP0009333_abnormal_splenocyte_physiolog2.19972302
16MP0002396_abnormal_hematopoietic_system2.13933398
17MP0003186_abnormal_redox_activity2.06396809
18MP0006072_abnormal_retinal_apoptosis2.04160589
19MP0003763_abnormal_thymus_physiology1.96451773
20MP0002938_white_spotting1.95845634
21MP0005671_abnormal_response_to1.86513277
22MP0001835_abnormal_antigen_presentation1.84960212
23MP0002638_abnormal_pupillary_reflex1.82160094
24MP0009379_abnormal_foot_pigmentation1.82033838
25MP0008875_abnormal_xenobiotic_pharmacok1.81521895
26MP0008260_abnormal_autophagy1.78353746
27MP0002132_abnormal_respiratory_system1.76337041
28MP0005084_abnormal_gallbladder_morpholo1.76094576
29MP0003195_calcinosis1.74465894
30MP0004142_abnormal_muscle_tone1.70430940
31MP0001730_embryonic_growth_arrest1.68905886
32MP0008877_abnormal_DNA_methylation1.66917900
33MP0000490_abnormal_crypts_of1.62409628
34MP0009785_altered_susceptibility_to1.54280609
35MP0000350_abnormal_cell_proliferation1.49252462
36MP0001853_heart_inflammation1.49014893
37MP0005253_abnormal_eye_physiology1.46740848
38MP0008995_early_reproductive_senescence1.45480769
39MP0002736_abnormal_nociception_after1.38220288
40MP0002398_abnormal_bone_marrow1.37576366
41MP0003315_abnormal_perineum_morphology1.37280049
42MP0002148_abnormal_hypersensitivity_rea1.37045369
43MP0003121_genomic_imprinting1.35394094
44MP0005551_abnormal_eye_electrophysiolog1.35251054
45MP0000689_abnormal_spleen_morphology1.34703052
46MP0005075_abnormal_melanosome_morpholog1.33980442
47MP0002722_abnormal_immune_system1.32912156
48MP0002019_abnormal_tumor_incidence1.30983164
49MP0006292_abnormal_olfactory_placode1.30298067
50MP0005397_hematopoietic_system_phenotyp1.29445694
51MP0001545_abnormal_hematopoietic_system1.29445694
52MP0006036_abnormal_mitochondrial_physio1.27845240
53MP0000313_abnormal_cell_death1.27129299
54MP0003880_abnormal_central_pattern1.25905007
55MP0005379_endocrine/exocrine_gland_phen1.25738934
56MP0001293_anophthalmia1.25551143
57MP0002452_abnormal_antigen_presenting1.24889027
58MP0002420_abnormal_adaptive_immunity1.23501942
59MP0001800_abnormal_humoral_immune1.23013338
60MP0001819_abnormal_immune_cell1.22661279
61MP0008872_abnormal_physiological_respon1.20342523
62MP0002723_abnormal_immune_serum1.19253459
63MP0003122_maternal_imprinting1.18540344
64MP0005025_abnormal_response_to1.18286797
65MP0000716_abnormal_immune_system1.17464185
66MP0005000_abnormal_immune_tolerance1.16800593
67MP0002429_abnormal_blood_cell1.16667830
68MP0002751_abnormal_autonomic_nervous1.16545316
69MP0001986_abnormal_taste_sensitivity1.14557577
70MP0003123_paternal_imprinting1.14174220
71MP0000685_abnormal_immune_system1.12912324
72MP0009046_muscle_twitch1.10955251
73MP0003136_yellow_coat_color1.10745828
74MP0001697_abnormal_embryo_size1.10234303
75MP0004808_abnormal_hematopoietic_stem1.09759369
76MP0000703_abnormal_thymus_morphology1.09296700
77MP0001984_abnormal_olfaction1.08686568
78MP0005380_embryogenesis_phenotype1.07435621
79MP0001672_abnormal_embryogenesis/_devel1.07435621
80MP0005451_abnormal_body_composition1.06787561
81MP0009697_abnormal_copulation1.06140027
82MP0002080_prenatal_lethality1.06006513
83MP0004147_increased_porphyrin_level1.05767431
84MP0002837_dystrophic_cardiac_calcinosis1.05493387
85MP0001919_abnormal_reproductive_system1.04635892
86MP0008789_abnormal_olfactory_epithelium1.03159541
87MP0003567_abnormal_fetal_cardiomyocyte1.02008515
88MP0002234_abnormal_pharynx_morphology1.00486945
89MP0000858_altered_metastatic_potential1.00306362
90MP0002405_respiratory_system_inflammati0.99007580
91MP0001764_abnormal_homeostasis0.98418201
92MP0002163_abnormal_gland_morphology0.97311269
93MP0003436_decreased_susceptibility_to0.95763013
94MP0002419_abnormal_innate_immunity0.93522348
95MP0001905_abnormal_dopamine_level0.93240153
96MP0000631_abnormal_neuroendocrine_gland0.92973380
97MP0002210_abnormal_sex_determination0.92752379
98MP0003984_embryonic_growth_retardation0.91698181
99MP0003698_abnormal_male_reproductive0.91349778
100MP0002088_abnormal_embryonic_growth/wei0.87885691
101MP0006035_abnormal_mitochondrial_morpho0.87642305
102MP0006276_abnormal_autonomic_nervous0.87159305
103MP0004381_abnormal_hair_follicle0.87151526
104MP0001968_abnormal_touch/_nociception0.86879012
105MP0005645_abnormal_hypothalamus_physiol0.85474973
106MP0000372_irregular_coat_pigmentation0.84640416
107MP0005408_hypopigmentation0.82297001
108MP0002085_abnormal_embryonic_tissue0.82282328
109MP0003221_abnormal_cardiomyocyte_apopto0.82037448
110MP0003011_delayed_dark_adaptation0.81989599
111MP0002277_abnormal_respiratory_mucosa0.81053575
112MP0000358_abnormal_cell_content/0.80128911
113MP0005085_abnormal_gallbladder_physiolo0.79731515
114MP0001119_abnormal_female_reproductive0.79254959
115MP0005410_abnormal_fertilization0.79029463
116MP0003646_muscle_fatigue0.78180266
117MP0001542_abnormal_bone_strength0.77981282
118MP0001145_abnormal_male_reproductive0.76783986
119MP0005646_abnormal_pituitary_gland0.76487611
120MP0001666_abnormal_nutrient_absorption0.76238313
121MP0002090_abnormal_vision0.75397787
122MP0010307_abnormal_tumor_latency0.75122709
123MP0005389_reproductive_system_phenotype0.74917761
124MP0002095_abnormal_skin_pigmentation0.74749377
125MP0005332_abnormal_amino_acid0.74738676
126MP0004782_abnormal_surfactant_physiolog0.74337680
127MP0005387_immune_system_phenotype0.74113320
128MP0001790_abnormal_immune_system0.74113320
129MP0010155_abnormal_intestine_physiology0.73477942
130MP0005395_other_phenotype0.72394130
131MP0000015_abnormal_ear_pigmentation0.72193545
132MP0003937_abnormal_limbs/digits/tail_de0.72081568
133MP0002160_abnormal_reproductive_system0.71872047
134MP0005391_vision/eye_phenotype0.71834565
135MP0001929_abnormal_gametogenesis0.71086326
136MP0001727_abnormal_embryo_implantation0.70631258
137MP0003656_abnormal_erythrocyte_physiolo0.69951018
138MP0003950_abnormal_plasma_membrane0.68716164
139MP0000653_abnormal_sex_gland0.68699322
140MP0005365_abnormal_bile_salt0.68547582
141MP0006082_CNS_inflammation0.68225473
142MP0002233_abnormal_nose_morphology0.68165630
143MP0001529_abnormal_vocalization0.67666109
144MP0003724_increased_susceptibility_to0.67412858
145MP0003787_abnormal_imprinting0.67312810
146MP0004215_abnormal_myocardial_fiber0.66877280
147MP0000516_abnormal_urinary_system0.66574709
148MP0005367_renal/urinary_system_phenotyp0.66574709
149MP0008873_increased_physiological_sensi0.65983375
150MP0005636_abnormal_mineral_homeostasis0.63807581
151MP0002161_abnormal_fertility/fecundity0.61759799
152MP0009745_abnormal_behavioral_response0.61076470
153MP0005499_abnormal_olfactory_system0.60365499
154MP0005394_taste/olfaction_phenotype0.60365499

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.69690565
2Abnormality of cells of the erythroid lineage (HP:0012130)4.11048925
3Abnormal number of erythroid precursors (HP:0012131)3.94291472
4Reticulocytopenia (HP:0001896)3.78331909
5Reduced antithrombin III activity (HP:0001976)3.72213685
6Breast hypoplasia (HP:0003187)3.69988383
7Cerebral hypomyelination (HP:0006808)3.67795321
8Hepatocellular necrosis (HP:0001404)3.40504224
9Carpal bone hypoplasia (HP:0001498)3.39159612
10Methylmalonic acidemia (HP:0002912)3.33798093
11Rough bone trabeculation (HP:0100670)3.32991749
12Aplastic anemia (HP:0001915)3.24435012
13Hepatic necrosis (HP:0002605)3.18905930
14Oral leukoplakia (HP:0002745)3.11495936
15Multiple enchondromatosis (HP:0005701)3.07385688
16Decreased activity of mitochondrial respiratory chain (HP:0008972)3.05358322
17Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.05358322
18Mitochondrial inheritance (HP:0001427)3.01857830
193-Methylglutaconic aciduria (HP:0003535)3.00151758
20Macrocytic anemia (HP:0001972)2.98086285
21Degeneration of anterior horn cells (HP:0002398)2.94630779
22Abnormality of the anterior horn cell (HP:0006802)2.94630779
23Increased CSF lactate (HP:0002490)2.91385298
24Abnormality of the pons (HP:0007361)2.90915903
25Increased serum lactate (HP:0002151)2.90421437
26Methylmalonic aciduria (HP:0012120)2.90211267
27Hypoplasia of the pons (HP:0012110)2.88704886
28Increased serum pyruvate (HP:0003542)2.86428055
29Abnormality of glycolysis (HP:0004366)2.86428055
30Aplasia/Hypoplasia of the uvula (HP:0010293)2.85791330
31Increased hepatocellular lipid droplets (HP:0006565)2.85099690
32Cerebral edema (HP:0002181)2.78727051
33Acute necrotizing encephalopathy (HP:0006965)2.76037257
34Pancreatic cysts (HP:0001737)2.72756357
35Abnormality of the labia minora (HP:0012880)2.63541444
36Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.60934298
37Microvesicular hepatic steatosis (HP:0001414)2.60173515
38Abnormality of DNA repair (HP:0003254)2.59624327
39Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.56589432
40Abnormal trabecular bone morphology (HP:0100671)2.55323968
41Patellar aplasia (HP:0006443)2.54120722
42Increased intramyocellular lipid droplets (HP:0012240)2.50780629
43Hypoproteinemia (HP:0003075)2.50547545
44Volvulus (HP:0002580)2.50325063
45Exertional dyspnea (HP:0002875)2.50020723
46Type I transferrin isoform profile (HP:0003642)2.48508755
47Premature graying of hair (HP:0002216)2.48140510
48Renal cortical cysts (HP:0000803)2.47805319
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.47025978
50Lipid accumulation in hepatocytes (HP:0006561)2.46384567
5111 pairs of ribs (HP:0000878)2.44414919
52Aplasia/Hypoplasia of the patella (HP:0006498)2.44349079
53Microretrognathia (HP:0000308)2.42691490
54Pallor (HP:0000980)2.40972562
55Abnormal mitochondria in muscle tissue (HP:0008316)2.40488735
56Irregular epiphyses (HP:0010582)2.36401172
57Respiratory difficulties (HP:0002880)2.33601369
58Optic disc pallor (HP:0000543)2.30274998
59IgM deficiency (HP:0002850)2.28485890
60Abnormality of the renal cortex (HP:0011035)2.28035015
61Type 2 muscle fiber atrophy (HP:0003554)2.26750728
62Chromsome breakage (HP:0040012)2.26674672
63Colon cancer (HP:0003003)2.26207515
64Abnormality of the preputium (HP:0100587)2.25574662
65Pancreatic fibrosis (HP:0100732)2.25554411
66Bone marrow hypocellularity (HP:0005528)2.25535888
67Secondary amenorrhea (HP:0000869)2.25180151
68Sparse eyelashes (HP:0000653)2.23116207
69Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.22996799
70Trismus (HP:0000211)2.22417431
71True hermaphroditism (HP:0010459)2.21578171
72Agnosia (HP:0010524)2.21368752
73Cleft eyelid (HP:0000625)2.21156157
74Generalized aminoaciduria (HP:0002909)2.20646895
75Thrombocytosis (HP:0001894)2.20500044
76Poor head control (HP:0002421)2.19094473
77Meckel diverticulum (HP:0002245)2.17865845
78CNS hypomyelination (HP:0003429)2.16961031
79Muscle fiber atrophy (HP:0100295)2.16939835
80Abnormality of the umbilical cord (HP:0010881)2.16743637
81Stenosis of the external auditory canal (HP:0000402)2.15733171
82Abnormality of midbrain morphology (HP:0002418)2.14141000
83Molar tooth sign on MRI (HP:0002419)2.14141000
84Absent thumb (HP:0009777)2.13199518
85Chromosomal breakage induced by crosslinking agents (HP:0003221)2.11322900
86Pancytopenia (HP:0001876)2.10633007
87Cellular immunodeficiency (HP:0005374)2.10586754
88Lymphoma (HP:0002665)2.10446208
89Acute encephalopathy (HP:0006846)2.09037060
90CNS demyelination (HP:0007305)2.08600580
91IgG deficiency (HP:0004315)2.07605791
92Leukodystrophy (HP:0002415)2.07352406
93Duodenal stenosis (HP:0100867)2.07233995
94Small intestinal stenosis (HP:0012848)2.07233995
95Myelodysplasia (HP:0002863)2.07181769
96Aplasia/Hypoplasia involving the musculature (HP:0001460)2.07133296
97Impulsivity (HP:0100710)2.06492677
98Abnormality of the ileum (HP:0001549)2.04814526
99Renal Fanconi syndrome (HP:0001994)2.03619939
100Absent radius (HP:0003974)2.02721919
101Premature ovarian failure (HP:0008209)2.02410720
102Congenital, generalized hypertrichosis (HP:0004540)2.01870941
103Clubbing of toes (HP:0100760)2.00467223
104Glossoptosis (HP:0000162)2.00136856
105Exercise intolerance (HP:0003546)2.00079869
106Progressive macrocephaly (HP:0004481)1.99024904
107Pancreatic islet-cell hyperplasia (HP:0004510)1.98772013
108Lactic acidosis (HP:0003128)1.98323723
109Hypoplasia of the capital femoral epiphysis (HP:0003090)1.97699508
110Selective tooth agenesis (HP:0001592)1.95940527
111Prolonged neonatal jaundice (HP:0006579)1.95785085
112Abnormality of methionine metabolism (HP:0010901)1.94544590
113Petechiae (HP:0000967)1.93952904
114Increased muscle lipid content (HP:0009058)1.93609231
115Respiratory failure (HP:0002878)1.93347519
116Abnormal lung lobation (HP:0002101)1.92643023
117Combined immunodeficiency (HP:0005387)1.90110702
118Supernumerary spleens (HP:0009799)1.89271198
119Abnormality of chromosome stability (HP:0003220)1.88871231
120Triphalangeal thumb (HP:0001199)1.88592943
121Medial flaring of the eyebrow (HP:0010747)1.88296888
122Hypoglycemic coma (HP:0001325)1.86202639
123Lethargy (HP:0001254)1.86139216
124Pendular nystagmus (HP:0012043)1.85951870
125Hypoplasia of the radius (HP:0002984)1.85439168
126Abnormality of the vitamin B12 metabolism (HP:0004341)1.85379547
127Severe combined immunodeficiency (HP:0004430)1.84888148
128Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.83123674
129Abnormal protein N-linked glycosylation (HP:0012347)1.83123674
130Abnormal protein glycosylation (HP:0012346)1.83123674
131Abnormal glycosylation (HP:0012345)1.83123674
132Glycosuria (HP:0003076)1.82582194
133Abnormality of urine glucose concentration (HP:0011016)1.82582194
134Absent forearm bone (HP:0003953)1.82535308
135Aplasia involving forearm bones (HP:0009822)1.82535308
136Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81642066
137Duplicated collecting system (HP:0000081)1.81153828
138Abnormality of the duodenum (HP:0002246)1.80315427
139Abnormality of vitamin B metabolism (HP:0004340)1.80272460
140Elevated erythrocyte sedimentation rate (HP:0003565)1.79226152
141Ependymoma (HP:0002888)1.78619408
142Nephronophthisis (HP:0000090)1.77941485
143Hyperglycinemia (HP:0002154)1.74585604
144Sloping forehead (HP:0000340)1.74423930
145Abnormality of the renal collecting system (HP:0004742)1.71237420
146Megaloblastic anemia (HP:0001889)1.70405461
147Abnormality of renal resorption (HP:0011038)1.68093181
148Stomatitis (HP:0010280)1.67243025

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.23955626
2WEE13.72761041
3EIF2AK13.43916889
4NME23.16055071
5MAP4K23.05568555
6STK163.04880211
7VRK23.02274810
8PLK42.79274540
9SRPK12.41126575
10EIF2AK32.40716322
11TSSK62.32170406
12WNK32.28726155
13PBK2.12294460
14VRK12.09926529
15TRIM282.00068002
16NEK11.95018730
17BRSK21.86845943
18PIM21.85697987
19CDC71.76013383
20ZAK1.67248773
21TESK21.65228880
22NEK21.65003561
23MKNK11.63847626
24EPHA21.58884884
25MST41.55955102
26PLK11.54527001
27TXK1.49001107
28TTK1.46999325
29IRAK31.44300523
30ERBB31.41393038
31MAP4K11.39763867
32FRK1.39079796
33AURKB1.35135088
34PLK31.34479070
35TLK11.32976749
36BMPR1B1.26887881
37RPS6KB21.26546414
38IRAK41.22764972
39AURKA1.14612915
40INSRR1.14559233
41ACVR1B1.13516290
42DYRK31.13181780
43GRK11.08605180
44ATR1.05850923
45EIF2AK21.04681375
46NME11.04120021
47CHEK21.01225527
48CDK191.00424296
49KDR0.99354059
50PIM10.97955882
51BRSK10.97135497
52PASK0.96542044
53MKNK20.94989665
54STK40.94678341
55BCR0.94417562
56RPS6KA40.93825298
57CDK70.90624626
58BRAF0.89815612
59CSNK1G10.89773295
60BLK0.89759893
61ARAF0.88159168
62MAPK130.86250381
63IKBKB0.84073111
64MAP3K80.81249683
65CLK10.80105641
66TEC0.78379464
67ZAP700.78139539
68CASK0.77234725
69RPS6KA50.76705027
70MAP3K40.76649879
71STK100.76194975
72PLK20.75781831
73CDK40.75398156
74CSNK1G20.73894082
75BCKDK0.73363845
76STK38L0.72109222
77NLK0.71649869
78KIT0.71217230
79DYRK20.71105265
80CSNK2A10.70909655
81CSNK1A1L0.70407286
82CHEK10.68870053
83OXSR10.68269028
84PNCK0.66927152
85CSNK2A20.66885637
86CCNB10.65673777
87MAP3K110.64858223
88TIE10.63133934
89CDK80.61536984
90PAK10.60709769
91AKT30.60552324
92BTK0.60404223
93PRKCE0.60183621
94TNIK0.59807281
95ABL20.59073968
96TESK10.58883363
97PAK40.57641705
98NUAK10.56256323
99MAP2K70.56249792
100MAP3K140.55245772
101MYLK0.55091239
102MAP3K30.54633957
103TAOK20.54275089
104MARK30.54056132
105PRKCI0.52984004
106ADRBK20.52611510
107STK240.50551455
108LYN0.49935990
109TAF10.49696277
110IKBKE0.49306469
111CSNK1E0.48697770
112PRKCG0.47499087
113TYK20.47367689
114PIK3CG0.47352879
115PDK20.47000505
116MUSK0.46398152
117SIK30.45347212
118CSNK1A10.45345405
119YES10.43055486
120CDK30.41289594
121MAP2K60.41275112
122STK30.41256444
123MAPKAPK30.41022121
124LIMK10.40203566
125CSNK1G30.38743307
126JAK30.38649755
127ILK0.38638104
128DAPK10.38443957
129TGFBR10.37984105
130CAMKK20.37944906
131CDK20.37643225
132CDK10.37482158
133STK390.37265657
134PRKDC0.36866162
135ATM0.36595805
136MAP3K120.35545137
137SYK0.35172087
138GRK70.34822342
139LRRK20.34612821
140PINK10.32527068
141MINK10.29906258
142CSNK1D0.29556178
143BMPR20.28131716

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.82765085
2Ribosome_Homo sapiens_hsa030104.12590650
3RNA polymerase_Homo sapiens_hsa030203.84018419
4DNA replication_Homo sapiens_hsa030303.68213045
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.41434755
6Mismatch repair_Homo sapiens_hsa034303.38395607
7Spliceosome_Homo sapiens_hsa030402.84591388
8Homologous recombination_Homo sapiens_hsa034402.57540507
9Pyrimidine metabolism_Homo sapiens_hsa002402.50559947
10RNA transport_Homo sapiens_hsa030132.47314799
11Nucleotide excision repair_Homo sapiens_hsa034202.46272264
12Base excision repair_Homo sapiens_hsa034102.43025114
13Basal transcription factors_Homo sapiens_hsa030222.07292871
14Protein export_Homo sapiens_hsa030601.94043230
15Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.92748387
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.89991617
17Non-homologous end-joining_Homo sapiens_hsa034501.81185783
18Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.81051158
19Cell cycle_Homo sapiens_hsa041101.80434764
20Oxidative phosphorylation_Homo sapiens_hsa001901.78613188
21Fanconi anemia pathway_Homo sapiens_hsa034601.77333898
22One carbon pool by folate_Homo sapiens_hsa006701.73013182
23Parkinsons disease_Homo sapiens_hsa050121.66931243
24RNA degradation_Homo sapiens_hsa030181.65579340
25Propanoate metabolism_Homo sapiens_hsa006401.56273839
26Vitamin B6 metabolism_Homo sapiens_hsa007501.53978044
27Huntingtons disease_Homo sapiens_hsa050161.40895924
28Purine metabolism_Homo sapiens_hsa002301.39266205
29Folate biosynthesis_Homo sapiens_hsa007901.26848105
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.24498802
31Epstein-Barr virus infection_Homo sapiens_hsa051691.22643239
32Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.20071267
33p53 signaling pathway_Homo sapiens_hsa041151.15856982
34Pyruvate metabolism_Homo sapiens_hsa006201.11375276
35Pentose phosphate pathway_Homo sapiens_hsa000301.06087653
36Primary immunodeficiency_Homo sapiens_hsa053401.06080574
37Cardiac muscle contraction_Homo sapiens_hsa042601.04265629
38Sulfur relay system_Homo sapiens_hsa041221.03960521
39Antigen processing and presentation_Homo sapiens_hsa046121.02322396
40Butanoate metabolism_Homo sapiens_hsa006501.01243709
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.00477209
42Glutathione metabolism_Homo sapiens_hsa004800.99327258
43Phototransduction_Homo sapiens_hsa047440.95742460
44Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.91280269
45mRNA surveillance pathway_Homo sapiens_hsa030150.89233627
46Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88028730
47Alzheimers disease_Homo sapiens_hsa050100.86796950
48Regulation of autophagy_Homo sapiens_hsa041400.84932374
49Peroxisome_Homo sapiens_hsa041460.81730180
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.81461649
51Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.79606565
52Graft-versus-host disease_Homo sapiens_hsa053320.76634447
53Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.75421633
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75085929
55Drug metabolism - other enzymes_Homo sapiens_hsa009830.74550753
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.74541829
57Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73138651
58Intestinal immune network for IgA production_Homo sapiens_hsa046720.71851000
59Herpes simplex infection_Homo sapiens_hsa051680.71678507
60Vitamin digestion and absorption_Homo sapiens_hsa049770.70952787
61Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.69302673
62Tryptophan metabolism_Homo sapiens_hsa003800.66750210
63Systemic lupus erythematosus_Homo sapiens_hsa053220.66744571
64Legionellosis_Homo sapiens_hsa051340.66290459
65Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.64475299
66beta-Alanine metabolism_Homo sapiens_hsa004100.64335201
67Sulfur metabolism_Homo sapiens_hsa009200.64111081
68Collecting duct acid secretion_Homo sapiens_hsa049660.62949900
69Fructose and mannose metabolism_Homo sapiens_hsa000510.62790356
70NF-kappa B signaling pathway_Homo sapiens_hsa040640.61139159
71Allograft rejection_Homo sapiens_hsa053300.61127778
72Maturity onset diabetes of the young_Homo sapiens_hsa049500.57703851
73Measles_Homo sapiens_hsa051620.57527905
74Arachidonic acid metabolism_Homo sapiens_hsa005900.56825050
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55370035
76Metabolic pathways_Homo sapiens_hsa011000.52502434
77Nitrogen metabolism_Homo sapiens_hsa009100.51392578
78Viral carcinogenesis_Homo sapiens_hsa052030.51169320
79Biosynthesis of amino acids_Homo sapiens_hsa012300.50812452
80Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.45611837
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45008966
82Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44487663
83NOD-like receptor signaling pathway_Homo sapiens_hsa046210.43838144
84Fatty acid degradation_Homo sapiens_hsa000710.43304057
85Carbon metabolism_Homo sapiens_hsa012000.41201455
86Hematopoietic cell lineage_Homo sapiens_hsa046400.39515477
87Caffeine metabolism_Homo sapiens_hsa002320.39486315
88Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.39414113
89Circadian rhythm_Homo sapiens_hsa047100.39229671
90Chemical carcinogenesis_Homo sapiens_hsa052040.39107298
91Apoptosis_Homo sapiens_hsa042100.38805805
92Autoimmune thyroid disease_Homo sapiens_hsa053200.38075632
93Galactose metabolism_Homo sapiens_hsa000520.37654172
94Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.36899237
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36249083
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.36047812
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.35985518
98Fatty acid elongation_Homo sapiens_hsa000620.35639219
99Selenocompound metabolism_Homo sapiens_hsa004500.35331470
100Primary bile acid biosynthesis_Homo sapiens_hsa001200.34688382
101Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.34432329
102Retinol metabolism_Homo sapiens_hsa008300.34000607
103Asthma_Homo sapiens_hsa053100.33842382
104Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.33707149
105Steroid biosynthesis_Homo sapiens_hsa001000.33705135
106Shigellosis_Homo sapiens_hsa051310.32536621
107Other glycan degradation_Homo sapiens_hsa005110.32284832
108Fatty acid metabolism_Homo sapiens_hsa012120.31809153
109Sphingolipid metabolism_Homo sapiens_hsa006000.30468580
110HTLV-I infection_Homo sapiens_hsa051660.30414782
111Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.30268053
112Cyanoamino acid metabolism_Homo sapiens_hsa004600.30075212
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.27943285
114Steroid hormone biosynthesis_Homo sapiens_hsa001400.26544190
115Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26312379
116Rheumatoid arthritis_Homo sapiens_hsa053230.25610697
117Influenza A_Homo sapiens_hsa051640.24453086
118Olfactory transduction_Homo sapiens_hsa047400.23491465
119Histidine metabolism_Homo sapiens_hsa003400.22117252
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.21825320
121Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.21169332
122Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20647160
123Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.18536558
124Oocyte meiosis_Homo sapiens_hsa041140.18289137
1252-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.18059798
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.17357514
127Arginine and proline metabolism_Homo sapiens_hsa003300.17289787
128N-Glycan biosynthesis_Homo sapiens_hsa005100.17188970
129Linoleic acid metabolism_Homo sapiens_hsa005910.16725388
130Ether lipid metabolism_Homo sapiens_hsa005650.15228151
131Malaria_Homo sapiens_hsa051440.13827452
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.13499188
133Jak-STAT signaling pathway_Homo sapiens_hsa046300.12534960
134Type I diabetes mellitus_Homo sapiens_hsa049400.11562659
135Transcriptional misregulation in cancer_Homo sapiens_hsa052020.11421699

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