NGEF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.87125825
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.79845706
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.78555840
4locomotory exploration behavior (GO:0035641)5.71821755
5regulation of synapse structural plasticity (GO:0051823)5.20677032
6vocalization behavior (GO:0071625)5.12577732
7synaptic vesicle docking involved in exocytosis (GO:0016081)5.01656980
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.98821173
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.89308089
10synaptic vesicle exocytosis (GO:0016079)4.86892943
11regulation of glutamate receptor signaling pathway (GO:1900449)4.79660559
12regulation of long-term neuronal synaptic plasticity (GO:0048169)4.78079539
13neurotransmitter-gated ion channel clustering (GO:0072578)4.77349657
14glutamate secretion (GO:0014047)4.72377717
15regulation of neuronal synaptic plasticity (GO:0048168)4.68606299
16cerebellar granule cell differentiation (GO:0021707)4.66562654
17amino acid import (GO:0043090)4.63219727
18regulation of synaptic vesicle exocytosis (GO:2000300)4.51722396
19prepulse inhibition (GO:0060134)4.46125236
20regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.37848249
21neurotransmitter secretion (GO:0007269)4.28683165
22positive regulation of dendritic spine morphogenesis (GO:0061003)4.28260645
23protein localization to synapse (GO:0035418)4.20211195
24ionotropic glutamate receptor signaling pathway (GO:0035235)4.18261756
25membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.14668264
26cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.13441464
27exploration behavior (GO:0035640)4.10445205
28positive regulation of synaptic transmission, glutamatergic (GO:0051968)4.07829467
29regulation of synaptic vesicle transport (GO:1902803)4.07433035
30auditory behavior (GO:0031223)4.05709150
31neuronal action potential propagation (GO:0019227)4.01798554
32layer formation in cerebral cortex (GO:0021819)4.00649919
33dendritic spine morphogenesis (GO:0060997)4.00447080
34gamma-aminobutyric acid transport (GO:0015812)3.96969671
35synaptic transmission, dopaminergic (GO:0001963)3.95307209
36regulation of ARF protein signal transduction (GO:0032012)3.95109877
37potassium ion homeostasis (GO:0055075)3.91648151
38synaptic vesicle endocytosis (GO:0048488)3.91171134
39negative regulation of synaptic transmission, GABAergic (GO:0032229)3.88753210
40synaptic transmission, glutamatergic (GO:0035249)3.85378940
41neuromuscular process controlling balance (GO:0050885)3.83200984
42neuron-neuron synaptic transmission (GO:0007270)3.81815508
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.81559310
44positive regulation of membrane potential (GO:0045838)3.80631461
45long-term memory (GO:0007616)3.79092693
46cytoskeletal anchoring at plasma membrane (GO:0007016)3.77496994
47positive regulation of neurotransmitter transport (GO:0051590)3.75290782
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.74220154
49behavioral response to cocaine (GO:0048148)3.71969462
50regulation of synapse maturation (GO:0090128)3.71494469
51response to auditory stimulus (GO:0010996)3.71034591
52positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.69842660
53axon ensheathment in central nervous system (GO:0032291)3.68514761
54central nervous system myelination (GO:0022010)3.68514761
55striatum development (GO:0021756)3.68202158
56regulation of synaptic plasticity (GO:0048167)3.68062910
57glutamate receptor signaling pathway (GO:0007215)3.65329860
58positive regulation of synaptic transmission, GABAergic (GO:0032230)3.64690455
59cellular sodium ion homeostasis (GO:0006883)3.64576007
60potassium ion import (GO:0010107)3.62958399
61adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.62030582
62regulation of synaptic transmission, glutamatergic (GO:0051966)3.61834841
63regulation of female receptivity (GO:0045924)3.61472026
64adenosine receptor signaling pathway (GO:0001973)3.59582433
65G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.59578987
66positive regulation of neurotransmitter secretion (GO:0001956)3.59451129
67regulation of postsynaptic membrane potential (GO:0060078)3.53625672
68* regulation of dendritic spine morphogenesis (GO:0061001)3.53511674
69activation of protein kinase A activity (GO:0034199)3.53188909
70cell communication by electrical coupling (GO:0010644)3.52536686
71cellular potassium ion homeostasis (GO:0030007)3.49720249
72negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.49081268
73cerebellar Purkinje cell differentiation (GO:0021702)3.47636145
74transmission of nerve impulse (GO:0019226)3.43768146
75response to amphetamine (GO:0001975)3.42571924
76postsynaptic membrane organization (GO:0001941)3.39831168
77regulation of glutamate secretion (GO:0014048)3.38437297
78long-term synaptic potentiation (GO:0060291)3.36797180
79acidic amino acid transport (GO:0015800)3.35468983
80dopamine receptor signaling pathway (GO:0007212)3.34360175
81gamma-aminobutyric acid signaling pathway (GO:0007214)3.31656582
82regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.30459107
83vesicle docking involved in exocytosis (GO:0006904)3.30082063
84neurotransmitter transport (GO:0006836)3.29602555
85proline transport (GO:0015824)3.29442334
86neuron cell-cell adhesion (GO:0007158)3.28949423
87glycine transport (GO:0015816)3.27278863
88regulation of neurotransmitter levels (GO:0001505)3.26897122
89response to histamine (GO:0034776)3.25530806
90female mating behavior (GO:0060180)3.24008129
91sodium ion export (GO:0071436)3.22452884
92dicarboxylic acid transport (GO:0006835)3.22057994
93neuronal ion channel clustering (GO:0045161)3.21743923
94behavioral fear response (GO:0001662)3.14178697
95behavioral defense response (GO:0002209)3.14178697
96regulation of voltage-gated calcium channel activity (GO:1901385)3.09300044
97positive regulation of dendritic spine development (GO:0060999)3.08834959
98regulation of neurotransmitter secretion (GO:0046928)3.08243623
99cAMP catabolic process (GO:0006198)3.08048663
100visual learning (GO:0008542)3.06236206
101chemosensory behavior (GO:0007635)3.06046683
102regulation of neurotransmitter transport (GO:0051588)3.05211192
103positive regulation of synaptic transmission (GO:0050806)3.05010877
104membrane hyperpolarization (GO:0060081)3.04867555
105neuromuscular process controlling posture (GO:0050884)3.04097850
106mating behavior (GO:0007617)3.03912757
107negative regulation of cytosolic calcium ion concentration (GO:0051481)3.03296668
108positive regulation of synapse maturation (GO:0090129)3.02843330
109vesicle docking (GO:0048278)3.01802065
110positive regulation of dendrite development (GO:1900006)3.01740532
111regulation of exocytosis (GO:0017157)3.01468022
112synaptic vesicle transport (GO:0048489)3.01207970
113establishment of synaptic vesicle localization (GO:0097480)3.01207970
114cell communication involved in cardiac conduction (GO:0086065)3.01022497
115synaptic transmission (GO:0007268)2.99548300
116acid secretion (GO:0046717)2.99517284
117membrane depolarization during action potential (GO:0086010)2.99207981
118mechanosensory behavior (GO:0007638)2.97919101
119serotonin metabolic process (GO:0042428)2.97377669
120L-glutamate transport (GO:0015813)2.97268389
121learning (GO:0007612)2.96718391
122cerebellar Purkinje cell layer development (GO:0021680)2.95473363
123dendritic spine organization (GO:0097061)2.95190876
124* regulation of dendritic spine development (GO:0060998)2.94899319
125neuromuscular process (GO:0050905)2.94861367
126response to gravity (GO:0009629)2.93678962
127regulation of neurotransmitter uptake (GO:0051580)2.91889403
128membrane depolarization (GO:0051899)2.91799389
129regulation of vesicle fusion (GO:0031338)2.91577889
130regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.91480959
131regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.91480959
132visual behavior (GO:0007632)2.90310219
133negative regulation of amino acid transport (GO:0051956)2.87847303
134alanine transport (GO:0032328)2.87535402
135regulation of synaptic transmission (GO:0050804)2.85233054
136fear response (GO:0042596)2.84529597
137L-amino acid import (GO:0043092)2.82443713

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.03031515
2RARB_27405468_Chip-Seq_BRAIN_Mouse3.41505679
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.02333176
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.98169535
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.85363180
6GBX2_23144817_ChIP-Seq_PC3_Human2.84688568
7DROSHA_22980978_ChIP-Seq_HELA_Human2.69127795
8MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.68131271
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.65741847
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.65741847
11REST_21632747_ChIP-Seq_MESCs_Mouse2.65103771
12* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.61177693
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.56366126
14* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.55089097
15* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.53099248
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41396673
17SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.37455077
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.28238007
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.27784378
20REST_18959480_ChIP-ChIP_MESCs_Mouse2.22302114
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.21110397
22EZH2_27294783_Chip-Seq_ESCs_Mouse2.19858775
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.11672597
24RNF2_27304074_Chip-Seq_ESCs_Mouse2.10874416
25EED_16625203_ChIP-ChIP_MESCs_Mouse2.06808794
26ERG_21242973_ChIP-ChIP_JURKAT_Human1.97290005
27AR_21572438_ChIP-Seq_LNCaP_Human1.95810244
28NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.83068617
29ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80970594
30LXR_22292898_ChIP-Seq_THP-1_Human1.71806382
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.62145885
32DNAJC2_21179169_ChIP-ChIP_NT2_Human1.58478270
33ESR2_21235772_ChIP-Seq_MCF-7_Human1.56660123
34SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.51328258
35SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42599445
36SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40507224
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38160819
38ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.37923551
39RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.36475378
40GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.36169183
41ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.35460082
42KDM2B_26808549_Chip-Seq_SUP-B15_Human1.32503992
43TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.32425183
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.31515113
45RING1B_27294783_Chip-Seq_ESCs_Mouse1.30251967
46KDM2B_26808549_Chip-Seq_K562_Human1.30143460
47SMAD4_21799915_ChIP-Seq_A2780_Human1.29866761
48EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26548575
49PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.26268242
50* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.25052682
51TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.24499015
52TAF15_26573619_Chip-Seq_HEK293_Human1.23434360
53SMC4_20622854_ChIP-Seq_HELA_Human1.21901946
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21442515
55* SOX2_21211035_ChIP-Seq_LN229_Gbm1.20808801
56CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19813256
57WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.19469192
58AR_19668381_ChIP-Seq_PC3_Human1.17601875
59CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.17332770
60ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17207403
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14909926
62THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13549274
63SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.12651244
64GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12313057
65P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11968061
66NR3C1_23031785_ChIP-Seq_PC12_Mouse1.11832273
67OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.10586827
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.10564163
69OCT4_19829295_ChIP-Seq_ESCs_Human1.08054901
70ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07495886
71CREB1_26743006_Chip-Seq_LNCaP_Human1.06457245
72UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06304934
73CTCF_27219007_Chip-Seq_Bcells_Human1.05898340
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.03932978
75PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.03263335
76PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.02068762
77STAT3_23295773_ChIP-Seq_U87_Human1.02036154
78PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01540078
79NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00936754
80P68_20966046_ChIP-Seq_HELA_Human1.00698225
81CTNNB1_20460455_ChIP-Seq_HCT116_Human1.00193846
82AR_25329375_ChIP-Seq_VCAP_Human0.99323167
83VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.99063192
84SMAD3_21741376_ChIP-Seq_HESCs_Human0.98754866
85TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.97316358
86TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.97126701
87RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.97023554
88TRIM28_21343339_ChIP-Seq_HEK293_Human0.96579899
89RXR_22108803_ChIP-Seq_LS180_Human0.96256884
90GATA1_26923725_Chip-Seq_HPCs_Mouse0.95619507
91P300_19829295_ChIP-Seq_ESCs_Human0.95067787
92TET1_21490601_ChIP-Seq_MESCs_Mouse0.94195699
93TET1_21451524_ChIP-Seq_MESCs_Mouse0.94167372
94RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.92405232
95MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.91297490
96SMAD4_21741376_ChIP-Seq_HESCs_Human0.90970572
97MYC_19915707_ChIP-ChIP_AK7_Human0.90967129
98ZFP281_27345836_Chip-Seq_ESCs_Mouse0.90329427
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90227015
100NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.89854540
101SMAD_19615063_ChIP-ChIP_OVARY_Human0.89829567
102ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89511404
103DPY_21335234_ChIP-Seq_ESCs_Mouse0.89400801
104* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89190400
105PIAS1_25552417_ChIP-Seq_VCAP_Human0.89189080
106SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88431245
107KLF4_19829295_ChIP-Seq_ESCs_Human0.87136693
108AHR_22903824_ChIP-Seq_MCF-7_Human0.86987182
109TCF4_23295773_ChIP-Seq_U87_Human0.86905045
110ARNT_22903824_ChIP-Seq_MCF-7_Human0.86741454
111RARG_19884340_ChIP-ChIP_MEFs_Mouse0.86706844
112BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85639164
113YAP1_20516196_ChIP-Seq_MESCs_Mouse0.85322659
114CDX2_19796622_ChIP-Seq_MESCs_Mouse0.84617301
115NR3C1_21868756_ChIP-Seq_MCF10A_Human0.84614983
116* ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.83957605
117TP53_16413492_ChIP-PET_HCT116_Human0.83093146
118* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.82205189
119SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82110323
120FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.82087680
121CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.81948940
122TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81153404
123SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81045566
124KDM2B_26808549_Chip-Seq_DND41_Human0.80102010
125SMAD3_21741376_ChIP-Seq_ESCs_Human0.79998567
126DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.79881264
127OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.79228893
128ZNF274_21170338_ChIP-Seq_K562_Hela0.78899231
129TP53_20018659_ChIP-ChIP_R1E_Mouse0.78870085
130ZFP57_27257070_Chip-Seq_ESCs_Mouse0.78861988
131AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78607276
132TP53_23651856_ChIP-Seq_MEFs_Mouse0.77778762
133* RUNX2_22187159_ChIP-Seq_PCA_Human0.77449797
134SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.77243738
135SMAD4_21741376_ChIP-Seq_ESCs_Human0.77065973
136EGR1_19032775_ChIP-ChIP_M12_Human0.76950959
137RUNX1_26923725_Chip-Seq_HPCs_Mouse0.76079397
138SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.75905077
139RACK7_27058665_Chip-Seq_MCF-7_Human0.75752262
140SA1_27219007_Chip-Seq_Bcells_Human0.74195038
141SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.73626332
142JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse0.73003283

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.81643628
2MP0002822_catalepsy6.47254836
3MP0003635_abnormal_synaptic_transmissio4.17750452
4MP0003880_abnormal_central_pattern4.12362002
5MP0009745_abnormal_behavioral_response3.60130956
6MP0004270_analgesia3.51939222
7MP0002063_abnormal_learning/memory/cond3.46769900
8MP0002064_seizures3.08960873
9MP0002572_abnormal_emotion/affect_behav2.78696757
10MP0009046_muscle_twitch2.76011263
11MP0001486_abnormal_startle_reflex2.74447659
12MP0001968_abnormal_touch/_nociception2.54713434
13MP0002272_abnormal_nervous_system2.35539671
14MP0005423_abnormal_somatic_nervous2.34801538
15MP0002734_abnormal_mechanical_nocicepti2.20766815
16MP0002909_abnormal_adrenal_gland2.19637076
17MP0001501_abnormal_sleep_pattern2.19318421
18MP0005646_abnormal_pituitary_gland2.14155613
19MP0003329_amyloid_beta_deposits2.10687118
20MP0009780_abnormal_chondrocyte_physiolo2.06135621
21MP0002736_abnormal_nociception_after1.84954535
22MP0003123_paternal_imprinting1.83606006
23MP0001529_abnormal_vocalization1.81831235
24MP0001440_abnormal_grooming_behavior1.80739529
25MP0002733_abnormal_thermal_nociception1.76557516
26MP0004924_abnormal_behavior1.73891928
27MP0005386_behavior/neurological_phenoty1.73891928
28MP0003075_altered_response_to1.72394049
29MP0008569_lethality_at_weaning1.72325752
30MP0001970_abnormal_pain_threshold1.71088517
31MP0002557_abnormal_social/conspecific_i1.63064873
32MP0004811_abnormal_neuron_physiology1.61561451
33MP0003879_abnormal_hair_cell1.60420987
34MP0001984_abnormal_olfaction1.57367468
35MP0004858_abnormal_nervous_system1.50910279
36MP0002067_abnormal_sensory_capabilities1.49225138
37MP0003633_abnormal_nervous_system1.44636749
38MP0004885_abnormal_endolymph1.43286272
39MP0005085_abnormal_gallbladder_physiolo1.36517458
40MP0003690_abnormal_glial_cell1.35262466
41MP0008872_abnormal_physiological_respon1.34756588
42MP0008874_decreased_physiological_sensi1.34084204
43MP0002735_abnormal_chemical_nociception1.32874316
44MP0003122_maternal_imprinting1.28830403
45MP0002066_abnormal_motor_capabilities/c1.28789492
46MP0001502_abnormal_circadian_rhythm1.25108308
47MP0000955_abnormal_spinal_cord1.24050951
48MP0005167_abnormal_blood-brain_barrier1.21300822
49MP0001177_atelectasis1.20244265
50MP0000604_amyloidosis1.19630191
51MP0003631_nervous_system_phenotype1.16123818
52MP0002184_abnormal_innervation1.15213640
53MP0005360_urolithiasis1.14649729
54MP0000778_abnormal_nervous_system1.13377310
55MP0001346_abnormal_lacrimal_gland1.13005906
56MP0002139_abnormal_hepatobiliary_system1.11101219
57MP0010234_abnormal_vibrissa_follicle1.10728585
58MP0001905_abnormal_dopamine_level1.10697961
59* MP0002882_abnormal_neuron_morphology1.09978780
60MP0008961_abnormal_basal_metabolism1.09611371
61MP0005535_abnormal_body_temperature1.08165140
62MP0005623_abnormal_meninges_morphology1.04254457
63MP0002069_abnormal_eating/drinking_beha1.02804648
64MP0002090_abnormal_vision1.02569140
65MP0004742_abnormal_vestibular_system1.02347850
66MP0003183_abnormal_peptide_metabolism1.01392921
67MP0004147_increased_porphyrin_level0.95848121
68MP0000013_abnormal_adipose_tissue0.95369194
69MP0004142_abnormal_muscle_tone0.88898959
70MP0003283_abnormal_digestive_organ0.88290728
71MP0002152_abnormal_brain_morphology0.88263352
72MP0008875_abnormal_xenobiotic_pharmacok0.87840352
73MP0005365_abnormal_bile_salt0.85664507
74MP0010329_abnormal_lipoprotein_level0.85626002
75MP0001348_abnormal_lacrimal_gland0.85579932
76MP0004085_abnormal_heartbeat0.84015670
77MP0005409_darkened_coat_color0.83313613
78MP0000751_myopathy0.82850977
79MP0005166_decreased_susceptibility_to0.81459607
80MP0001188_hyperpigmentation0.77735380
81MP0000920_abnormal_myelination0.76642661
82MP0005645_abnormal_hypothalamus_physiol0.75521132
83MP0000579_abnormal_nail_morphology0.75329410
84MP0002229_neurodegeneration0.75087966
85MP0000566_synostosis0.74204346
86MP0002089_abnormal_postnatal_growth/wei0.73979506
87MP0003632_abnormal_nervous_system0.73969006
88MP0004043_abnormal_pH_regulation0.72090218
89MP0003787_abnormal_imprinting0.70871400
90MP0003634_abnormal_glial_cell0.68499041
91MP0010386_abnormal_urinary_bladder0.67612955
92MP0001664_abnormal_digestion0.64204510
93MP0005551_abnormal_eye_electrophysiolog0.64110034
94MP0006276_abnormal_autonomic_nervous0.63830255
95MP0000569_abnormal_digit_pigmentation0.63557459
96MP0005584_abnormal_enzyme/coenzyme_acti0.62228299
97MP0003137_abnormal_impulse_conducting0.60966012
98MP0004130_abnormal_muscle_cell0.58504158
99MP0005332_abnormal_amino_acid0.55225161
100MP0002249_abnormal_larynx_morphology0.54958303
101MP0002876_abnormal_thyroid_physiology0.54844698
102MP0001765_abnormal_ion_homeostasis0.54003339
103MP0010769_abnormal_survival0.51269871
104MP0002118_abnormal_lipid_homeostasis0.50911749
105MP0005394_taste/olfaction_phenotype0.50304416
106MP0005499_abnormal_olfactory_system0.50304416
107MP0001986_abnormal_taste_sensitivity0.49111126
108MP0001963_abnormal_hearing_physiology0.48894573
109MP0004510_myositis0.48475260
110MP0000631_abnormal_neuroendocrine_gland0.48327099
111MP0005448_abnormal_energy_balance0.48029428
112MP0001485_abnormal_pinna_reflex0.48017421
113MP0001943_abnormal_respiration0.47915660
114MP0010768_mortality/aging0.47379070
115MP0000639_abnormal_adrenal_gland0.46804372
116MP0002082_postnatal_lethality0.46600963
117MP0010770_preweaning_lethality0.46600963
118MP0003956_abnormal_body_size0.45165659
119MP0002752_abnormal_somatic_nervous0.44903588
120MP0003172_abnormal_lysosome_physiology0.44839361
121MP0001666_abnormal_nutrient_absorption0.44605006
122MP0003045_fibrosis0.44074413
123MP0002638_abnormal_pupillary_reflex0.43511650
124MP0008260_abnormal_autophagy0.43087375
125MP0002873_normal_phenotype0.43000353
126MP0002254_reproductive_system_inflammat0.42387169

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)8.63341066
2Focal motor seizures (HP:0011153)7.62082900
3Focal seizures (HP:0007359)5.66690154
4Visual hallucinations (HP:0002367)4.49169477
5Epileptic encephalopathy (HP:0200134)4.23598411
6Torticollis (HP:0000473)4.11986737
7Poor eye contact (HP:0000817)3.93003140
8Action tremor (HP:0002345)3.81029560
9Generalized tonic-clonic seizures (HP:0002069)3.79809611
10Impaired vibration sensation in the lower limbs (HP:0002166)3.72461560
11Focal dystonia (HP:0004373)3.69329917
12Ankle clonus (HP:0011448)3.66107754
13Impaired social interactions (HP:0000735)3.65816991
14Abnormal social behavior (HP:0012433)3.65816991
15Anxiety (HP:0000739)3.59370675
16Absence seizures (HP:0002121)3.55984761
17Craniofacial dystonia (HP:0012179)3.53631588
18Febrile seizures (HP:0002373)3.51248149
19Atonic seizures (HP:0010819)3.49798942
20Depression (HP:0000716)3.45715918
21Annular pancreas (HP:0001734)3.37628600
22Dysdiadochokinesis (HP:0002075)3.37124221
23Resting tremor (HP:0002322)3.32553946
24Dialeptic seizures (HP:0011146)3.32099331
25Broad-based gait (HP:0002136)3.28096195
26Urinary bladder sphincter dysfunction (HP:0002839)3.23017857
27Postural instability (HP:0002172)3.22672544
28Cerebral hypomyelination (HP:0006808)3.21301706
29Megalencephaly (HP:0001355)3.12826911
30Status epilepticus (HP:0002133)3.12191490
31Progressive cerebellar ataxia (HP:0002073)3.09971558
32Abnormality of the lower motor neuron (HP:0002366)3.07263464
33Supranuclear gaze palsy (HP:0000605)3.05270388
34Dysmetria (HP:0001310)3.04937928
35Hyperventilation (HP:0002883)3.04869054
36Gaze-evoked nystagmus (HP:0000640)3.04063506
37Akinesia (HP:0002304)3.00552450
38Neurofibrillary tangles (HP:0002185)3.00161016
39Urinary urgency (HP:0000012)2.92684707
40Papilledema (HP:0001085)2.91443482
41Abnormal eating behavior (HP:0100738)2.90344774
42Ankyloglossia (HP:0010296)2.79685307
43Stereotypic behavior (HP:0000733)2.79213006
44Cerebral inclusion bodies (HP:0100314)2.79079867
45Apathy (HP:0000741)2.74396279
46Intention tremor (HP:0002080)2.73246017
47Scanning speech (HP:0002168)2.70133993
48Impaired vibratory sensation (HP:0002495)2.69960713
49Dysmetric saccades (HP:0000641)2.67342578
50Truncal ataxia (HP:0002078)2.63673303
51Bradykinesia (HP:0002067)2.61432776
52Spastic gait (HP:0002064)2.57846218
53Amblyopia (HP:0000646)2.51815646
54Hemiplegia (HP:0002301)2.50218987
55Distal upper limb amyotrophy (HP:0007149)2.48707857
56Upper limb amyotrophy (HP:0009129)2.48707857
57Polygenic inheritance (HP:0010982)2.48290035
58Mutism (HP:0002300)2.46120583
59Impaired smooth pursuit (HP:0007772)2.45271365
60Diminished motivation (HP:0000745)2.43101757
61Pointed chin (HP:0000307)2.37209951
62Hand muscle atrophy (HP:0009130)2.37167091
63Lower limb amyotrophy (HP:0007210)2.32999819
64Abnormality of the corticospinal tract (HP:0002492)2.32466462
65Ventricular fibrillation (HP:0001663)2.32309516
66Epileptiform EEG discharges (HP:0011182)2.31952697
67Clonus (HP:0002169)2.29401906
68Hemiparesis (HP:0001269)2.27781710
69Peripheral hypomyelination (HP:0007182)2.27692706
70EEG with generalized epileptiform discharges (HP:0011198)2.26251754
71Sleep apnea (HP:0010535)2.25950235
72Hypsarrhythmia (HP:0002521)2.22070738
73Generalized myoclonic seizures (HP:0002123)2.19659965
74Atrioventricular block (HP:0001678)2.12367170
75Abnormality of ocular smooth pursuit (HP:0000617)2.11721959
76Bronchomalacia (HP:0002780)2.10905245
77Lower limb muscle weakness (HP:0007340)2.10275276
78Abnormality of the periventricular white matter (HP:0002518)2.09082459
79Rapidly progressive (HP:0003678)2.08323698
80Choreoathetosis (HP:0001266)2.07386536
81Incomplete penetrance (HP:0003829)2.07287723
82Abnormal EKG (HP:0003115)2.06845571
83Prolonged QT interval (HP:0001657)2.06274115
84Aplasia involving bones of the extremities (HP:0009825)2.05874792
85Aplasia involving bones of the upper limbs (HP:0009823)2.05874792
86Aplasia of the phalanges of the hand (HP:0009802)2.05874792
87Genetic anticipation (HP:0003743)2.05714862
88Excessive salivation (HP:0003781)2.05708881
89Drooling (HP:0002307)2.05708881
90Tetraplegia (HP:0002445)2.04496340
91Bundle branch block (HP:0011710)2.03601181
92Heart block (HP:0012722)2.01438170
93Rigidity (HP:0002063)2.00525787
94Abnormality of binocular vision (HP:0011514)1.98079441
95Diplopia (HP:0000651)1.98079441
96Delayed CNS myelination (HP:0002188)1.97612070
97Progressive inability to walk (HP:0002505)1.97585731
98Abnormality of oral frenula (HP:0000190)1.95576315
99CNS hypomyelination (HP:0003429)1.95490471
100Obstructive sleep apnea (HP:0002870)1.94916333
101Spinal canal stenosis (HP:0003416)1.94600424
102Lower limb asymmetry (HP:0100559)1.94300602
103Dementia (HP:0000726)1.93061226
104Neuronal loss in central nervous system (HP:0002529)1.90129186
105Termporal pattern (HP:0011008)1.89984474
106Insidious onset (HP:0003587)1.89984474
107Abnormality of saccadic eye movements (HP:0000570)1.88474780
108Limb dystonia (HP:0002451)1.87708274
109Insomnia (HP:0100785)1.83828255
110Fetal akinesia sequence (HP:0001989)1.82636257
111Spastic tetraparesis (HP:0001285)1.81918739
112Memory impairment (HP:0002354)1.81588953
113Gait ataxia (HP:0002066)1.81235753
114Abnormal atrioventricular conduction (HP:0005150)1.81128224
115Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.80804989
116Degeneration of the lateral corticospinal tracts (HP:0002314)1.80804989
117Delusions (HP:0000746)1.78276330
118Distal sensory impairment (HP:0002936)1.77924786
119Abnormality of the Achilles tendon (HP:0005109)1.77463031
120Sensorimotor neuropathy (HP:0007141)1.76704544
121Morphological abnormality of the pyramidal tract (HP:0002062)1.72304975
122Confusion (HP:0001289)1.68379585
123Neonatal onset (HP:0003623)1.67983531
124Split foot (HP:0001839)1.66950036
125Increased circulating renin level (HP:0000848)1.64187416
126Hammertoe (HP:0001765)1.63721282

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.26996748
2MAP3K94.09969311
3DAPK23.61812158
4PRKD32.92230616
5KSR22.88961252
6* EPHA42.83645832
7CAMKK12.42407580
8MINK12.41218544
9MAP3K42.39177336
10RIPK42.34260967
11PAK62.23902128
12MARK12.06092556
13NTRK22.02857186
14MAP3K131.96515319
15NTRK11.93222207
16DAPK11.91103438
17MAP2K71.84110595
18ARAF1.81623840
19KSR11.80631169
20TAOK11.78316800
21CDK51.69901163
22MAP2K41.68434996
23MAP3K21.56786070
24FES1.50924390
25TYRO31.48596178
26TNIK1.47564610
27SIK21.41841387
28STK381.38216881
29PRPF4B1.29478284
30PINK11.24160063
31CAMKK21.22795864
32RAF11.19348609
33LMTK21.17226607
34PRKCG1.14135664
35SGK2231.11266148
36SGK4941.11266148
37MAP3K121.07488984
38CDK191.06237910
39PRKCH1.04239586
40GRK51.00307181
41CAMK10.97966526
42SGK30.96769556
43SGK20.96114565
44PLK20.95829272
45STK110.94935950
46CDK150.92456812
47CDK180.92165834
48MAP3K110.91915791
49PDPK10.91094760
50BMPR20.90754802
51MST1R0.90217634
52NEK10.88626346
53PTK2B0.87437009
54RIPK10.85730055
55PDK10.85173423
56MAPK130.85028468
57CAMK2A0.84381903
58RET0.84294077
59CDK140.84154864
60MARK20.84072410
61PHKG10.84053905
62PHKG20.84053905
63UHMK10.83062291
64SGK10.81316861
65TESK10.81098632
66MAP3K10.80374588
67CDK11A0.79943240
68LIMK10.77497034
69ALK0.74225267
70TRIB30.73386416
71CASK0.70257926
72DAPK30.68749893
73TNK20.68187416
74OXSR10.66718313
75CAMK2B0.66543018
76PRKG20.65949839
77MAP2K10.64778193
78PRKCZ0.63353415
79LATS20.61254734
80EPHA20.60890337
81RPS6KA30.58161130
82MAP3K70.57705166
83BRSK10.55661889
84CAMK40.54855384
85PAK30.54164139
86NEK60.50820415
87FYN0.50004092
88PKN10.49322535
89ICK0.48035025
90DYRK1A0.46759117
91FGFR20.46455364
92ROCK20.46402356
93CAMK2D0.44716882
94BRAF0.44515290
95CAMK2G0.43018259
96CSNK1G20.42913181
97MAPK100.42598285
98MAPK120.42428960
99PRKD20.42321436
100DMPK0.41596112
101PTK20.41256904
102MAP2K60.39868778
103MOS0.39686655
104DDR20.39549609
105ERBB20.39418989
106MET0.37620335
107PRKCE0.36473851
108CDC42BPA0.35589747
109WNK10.35440095
110BMX0.35264166
111PRKCB0.34584165
112IRAK20.34549763
113PRKCA0.33813716
114PRKACG0.33590167
115SCYL20.32131928
116CCNB10.31176860
117CAMK1G0.30079486
118MAPK80.28139164
119ROCK10.27995804

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.42873340
2Olfactory transduction_Homo sapiens_hsa047403.18028554
3Nicotine addiction_Homo sapiens_hsa050332.87380593
4Synaptic vesicle cycle_Homo sapiens_hsa047212.82387365
5GABAergic synapse_Homo sapiens_hsa047272.53536273
6Circadian entrainment_Homo sapiens_hsa047132.52268684
7Morphine addiction_Homo sapiens_hsa050322.44824047
8Amphetamine addiction_Homo sapiens_hsa050312.43548356
9Glutamatergic synapse_Homo sapiens_hsa047242.38312469
10Long-term potentiation_Homo sapiens_hsa047202.37868566
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.21650992
12Vitamin B6 metabolism_Homo sapiens_hsa007502.11802765
13Cocaine addiction_Homo sapiens_hsa050302.05536470
14Salivary secretion_Homo sapiens_hsa049702.03662342
15Dopaminergic synapse_Homo sapiens_hsa047282.01891276
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.89718080
17Cholinergic synapse_Homo sapiens_hsa047251.85040337
18Insulin secretion_Homo sapiens_hsa049111.80285948
19Gastric acid secretion_Homo sapiens_hsa049711.78206175
20Aldosterone synthesis and secretion_Homo sapiens_hsa049251.76573579
21Renin secretion_Homo sapiens_hsa049241.64178002
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.61823476
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.58780332
24Oxytocin signaling pathway_Homo sapiens_hsa049211.53527172
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52569563
26Calcium signaling pathway_Homo sapiens_hsa040201.45734902
27Arginine biosynthesis_Homo sapiens_hsa002201.41032946
28GnRH signaling pathway_Homo sapiens_hsa049121.30376654
29Long-term depression_Homo sapiens_hsa047301.28038071
30Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.26823959
31Gap junction_Homo sapiens_hsa045401.26493210
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.25484479
33Serotonergic synapse_Homo sapiens_hsa047261.25270160
34Taste transduction_Homo sapiens_hsa047421.22092508
35Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.20487747
36cAMP signaling pathway_Homo sapiens_hsa040241.20439464
37Bile secretion_Homo sapiens_hsa049761.16828061
38Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.14216077
39Glioma_Homo sapiens_hsa052141.02396019
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02307477
41Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95021027
42Butanoate metabolism_Homo sapiens_hsa006500.94533447
43Type II diabetes mellitus_Homo sapiens_hsa049300.92685657
44Estrogen signaling pathway_Homo sapiens_hsa049150.90237920
45Collecting duct acid secretion_Homo sapiens_hsa049660.88354235
46Phosphatidylinositol signaling system_Homo sapiens_hsa040700.88101580
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85799139
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85785353
49Melanogenesis_Homo sapiens_hsa049160.84208015
50Histidine metabolism_Homo sapiens_hsa003400.83635448
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.81495599
52Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.81087056
53Cyanoamino acid metabolism_Homo sapiens_hsa004600.79371225
54ErbB signaling pathway_Homo sapiens_hsa040120.77666349
55Phospholipase D signaling pathway_Homo sapiens_hsa040720.77608040
56Arginine and proline metabolism_Homo sapiens_hsa003300.76989754
57Thyroid hormone synthesis_Homo sapiens_hsa049180.75635106
58Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.74046237
59Pancreatic secretion_Homo sapiens_hsa049720.69490152
60Inositol phosphate metabolism_Homo sapiens_hsa005620.67705281
61Fatty acid biosynthesis_Homo sapiens_hsa000610.66876838
62Dorso-ventral axis formation_Homo sapiens_hsa043200.66554427
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62958770
64Glucagon signaling pathway_Homo sapiens_hsa049220.59821292
65Mineral absorption_Homo sapiens_hsa049780.57814199
66Carbohydrate digestion and absorption_Homo sapiens_hsa049730.57148780
67Oocyte meiosis_Homo sapiens_hsa041140.55531009
68Cardiac muscle contraction_Homo sapiens_hsa042600.55315092
69* Axon guidance_Homo sapiens_hsa043600.54916196
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54639893
71Prion diseases_Homo sapiens_hsa050200.53520485
72Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53498772
73Rap1 signaling pathway_Homo sapiens_hsa040150.53042284
742-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53014418
75Choline metabolism in cancer_Homo sapiens_hsa052310.52756968
76Dilated cardiomyopathy_Homo sapiens_hsa054140.52674205
77Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.52003089
78Non-small cell lung cancer_Homo sapiens_hsa052230.51493499
79VEGF signaling pathway_Homo sapiens_hsa043700.47941909
80Phenylalanine metabolism_Homo sapiens_hsa003600.46938864
81SNARE interactions in vesicular transport_Homo sapiens_hsa041300.46529676
82Circadian rhythm_Homo sapiens_hsa047100.45064966
83MAPK signaling pathway_Homo sapiens_hsa040100.44959838
84Alcoholism_Homo sapiens_hsa050340.43980579
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43629414
86Neurotrophin signaling pathway_Homo sapiens_hsa047220.42717422
87Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.41795061
88PPAR signaling pathway_Homo sapiens_hsa033200.41757866
89Phototransduction_Homo sapiens_hsa047440.41544050
90Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.40012711
91Vibrio cholerae infection_Homo sapiens_hsa051100.39771333
92Type I diabetes mellitus_Homo sapiens_hsa049400.39724306
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.38361340
94Sphingolipid signaling pathway_Homo sapiens_hsa040710.37445833
95mTOR signaling pathway_Homo sapiens_hsa041500.37244983
96Ras signaling pathway_Homo sapiens_hsa040140.36150958
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.34010130
98Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.33735022
99Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.33590473
100African trypanosomiasis_Homo sapiens_hsa051430.33249973
101Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33117106
102Insulin signaling pathway_Homo sapiens_hsa049100.32852782
103Ovarian steroidogenesis_Homo sapiens_hsa049130.32731219
104Glycerolipid metabolism_Homo sapiens_hsa005610.31622802
105Endocytosis_Homo sapiens_hsa041440.30632383
106Wnt signaling pathway_Homo sapiens_hsa043100.30398220
107Protein digestion and absorption_Homo sapiens_hsa049740.30249562
108Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.29991605
109Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.29648421
110AMPK signaling pathway_Homo sapiens_hsa041520.29192330
111Fatty acid metabolism_Homo sapiens_hsa012120.29117249
112Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29007525
113Fatty acid degradation_Homo sapiens_hsa000710.28259056
114Tight junction_Homo sapiens_hsa045300.26553658
115Endometrial cancer_Homo sapiens_hsa052130.26293443
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.26222727
117Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24142711
118HIF-1 signaling pathway_Homo sapiens_hsa040660.22013039

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