NGF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cartilage development involved in endochondral bone morphogenesis (GO:0060351)8.02508065
2collagen fibril organization (GO:0030199)6.94520275
3chondrocyte development (GO:0002063)6.34733954
4cell aggregation (GO:0098743)6.24255404
5cartilage condensation (GO:0001502)6.24255404
6chondrocyte proliferation (GO:0035988)6.20893940
7keratan sulfate catabolic process (GO:0042340)5.42846806
8kidney mesenchyme development (GO:0072074)5.42582386
9wound healing, spreading of epidermal cells (GO:0035313)5.31077531
10regulation of plasminogen activation (GO:0010755)5.15912024
11cell migration involved in heart development (GO:0060973)5.15612789
12protein retention in ER lumen (GO:0006621)5.13324292
13skin morphogenesis (GO:0043589)5.13300190
14endodermal cell differentiation (GO:0035987)5.11916404
15maintenance of protein localization in endoplasmic reticulum (GO:0035437)5.09881465
16notochord development (GO:0030903)4.97325007
17positive regulation of extracellular matrix organization (GO:1903055)4.89647367
18metanephric mesenchyme development (GO:0072075)4.80042764
19extracellular fibril organization (GO:0043206)4.69790773
20endothelial cell morphogenesis (GO:0001886)4.69275242
21type B pancreatic cell proliferation (GO:0044342)4.59228502
22sequestering of extracellular ligand from receptor (GO:0035581)4.47000963
23cell adhesion mediated by integrin (GO:0033627)4.37689992
24peptidyl-proline hydroxylation (GO:0019511)4.26340507
25wound healing, spreading of cells (GO:0044319)4.25556539
26extracellular matrix assembly (GO:0085029)4.23363299
27collagen metabolic process (GO:0032963)4.14479361
28collagen catabolic process (GO:0030574)4.12369942
29regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.09941917
30positive regulation of endothelial cell apoptotic process (GO:2000353)4.05901774
31negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)4.05585625
32fibril organization (GO:0097435)4.04876327
33chondroitin sulfate biosynthetic process (GO:0030206)3.98159967
34adhesion of symbiont to host cell (GO:0044650)3.97537611
35virion attachment to host cell (GO:0019062)3.97537611
36cellular response to vitamin (GO:0071295)3.95495970
37negative regulation of fibrinolysis (GO:0051918)3.93624871
38protein heterotrimerization (GO:0070208)3.89604975
39COPI coating of Golgi vesicle (GO:0048205)3.88281889
40Golgi transport vesicle coating (GO:0048200)3.88281889
41multicellular organismal macromolecule metabolic process (GO:0044259)3.83317947
42substrate-dependent cell migration (GO:0006929)3.82072841
43multicellular organismal catabolic process (GO:0044243)3.76192126
44proteoglycan metabolic process (GO:0006029)3.74584137
45response to gravity (GO:0009629)3.74521331
46extracellular matrix disassembly (GO:0022617)3.73015429
47embryonic skeletal joint morphogenesis (GO:0060272)3.69190196
48cellular response to vitamin D (GO:0071305)3.68843875
49dermatan sulfate biosynthetic process (GO:0030208)3.65967782
50multicellular organismal metabolic process (GO:0044236)3.64722334
51limb bud formation (GO:0060174)3.61817150
52mesenchymal-epithelial cell signaling (GO:0060638)3.60415606
53protein hydroxylation (GO:0018126)3.60298888
54regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.58340639
55nucleotide-sugar biosynthetic process (GO:0009226)3.57859112
56venous blood vessel morphogenesis (GO:0048845)3.57109249
57regulation of integrin-mediated signaling pathway (GO:2001044)3.55720581
58negative regulation of fatty acid transport (GO:2000192)3.54459409
59positive regulation of blood vessel endothelial cell migration (GO:0043536)3.50010633
60heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.48831541
61positive regulation of cartilage development (GO:0061036)3.45165121
62cartilage development (GO:0051216)3.44110877
63regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.43666274
64bone trabecula formation (GO:0060346)3.41849302
65extracellular regulation of signal transduction (GO:1900115)3.39173534
66extracellular negative regulation of signal transduction (GO:1900116)3.39173534
67positive regulation of osteoblast proliferation (GO:0033690)3.33596596
68atrioventricular valve morphogenesis (GO:0003181)3.33292471
69endocardial cushion development (GO:0003197)3.32285859
70positive regulation of fibroblast migration (GO:0010763)3.29100262
71regulation of tight junction assembly (GO:2000810)3.28928251
72adhesion of symbiont to host (GO:0044406)3.28385171
73endochondral ossification (GO:0001958)3.27924522
74replacement ossification (GO:0036075)3.27924522
75smooth muscle tissue development (GO:0048745)3.26937517
76dermatan sulfate metabolic process (GO:0030205)3.25470045
77negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)3.24672668
78fibrinolysis (GO:0042730)3.21733101
79extracellular matrix organization (GO:0030198)3.20069754
80extracellular structure organization (GO:0043062)3.18917202
81negative regulation of smooth muscle cell differentiation (GO:0051151)3.16286956
82plasma membrane repair (GO:0001778)3.15109038
83negative regulation of BMP signaling pathway (GO:0030514)3.14075658
84COPII vesicle coating (GO:0048208)3.13282352
85substrate adhesion-dependent cell spreading (GO:0034446)3.12598475
86connective tissue development (GO:0061448)3.09208054
87glomerular basement membrane development (GO:0032836)3.08204125
88cellular glucuronidation (GO:0052695)3.06042022
89sprouting angiogenesis (GO:0002040)3.05250237
90regulation of cartilage development (GO:0061035)3.03729774
91negative regulation of nitric-oxide synthase activity (GO:0051001)3.01786019
92barbed-end actin filament capping (GO:0051016)3.01454799
93negative regulation of gluconeogenesis (GO:0045721)3.00992305
94negative regulation of osteoblast proliferation (GO:0033689)3.00943141
95short-term memory (GO:0007614)2.99806887
96positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.99402951
97negative regulation of axon extension involved in axon guidance (GO:0048843)2.96717989
98planar cell polarity pathway involved in neural tube closure (GO:0090179)2.96697557
99vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.95127523
100blood vessel maturation (GO:0001955)2.94713748
101negative regulation of chondrocyte differentiation (GO:0032331)2.94594013
102apoptotic cell clearance (GO:0043277)2.94281005
103vascular endothelial growth factor signaling pathway (GO:0038084)2.90751910
104positive regulation of chondrocyte differentiation (GO:0032332)2.90673723
105regulation of chondrocyte differentiation (GO:0032330)2.90528659
106endocardial cushion morphogenesis (GO:0003203)2.87188591
107neuron projection extension involved in neuron projection guidance (GO:1902284)2.86836679
108axon extension involved in axon guidance (GO:0048846)2.86836679
109tooth mineralization (GO:0034505)2.84698886
110membrane raft organization (GO:0031579)2.82699695
111peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.82644546
112stress fiber assembly (GO:0043149)2.82435237
113glycosaminoglycan biosynthetic process (GO:0006024)2.79828265
114regulation of apoptotic process involved in morphogenesis (GO:1902337)2.78744948
115regulation of G0 to G1 transition (GO:0070316)2.78413367
116mesodermal cell differentiation (GO:0048333)2.78179369
117lung vasculature development (GO:0060426)2.77981546
118epithelial to mesenchymal transition (GO:0001837)2.77455195
119regulation of osteoblast proliferation (GO:0033688)2.77193875
120negative regulation of smooth muscle cell migration (GO:0014912)2.77146612
121basement membrane organization (GO:0071711)2.76086550
122protein localization to endosome (GO:0036010)2.75705430
123lymphangiogenesis (GO:0001946)2.75685281
124retina vasculature morphogenesis in camera-type eye (GO:0061299)2.75198966
125face morphogenesis (GO:0060325)2.75050450
126regulation of fibrinolysis (GO:0051917)2.75022316
127actin filament depolymerization (GO:0030042)2.74816938
128middle ear morphogenesis (GO:0042474)2.74736132
129positive regulation of epithelial to mesenchymal transition (GO:0010718)2.74514447
130aminoglycan biosynthetic process (GO:0006023)2.74183344
131cellular response to amino acid stimulus (GO:0071230)2.74089936
132glucuronate metabolic process (GO:0019585)2.74011219
133uronic acid metabolic process (GO:0006063)2.74011219
134trabecula formation (GO:0060343)2.72999983
135positive regulation of p38MAPK cascade (GO:1900745)2.72878821
136platelet degranulation (GO:0002576)2.72240186
137cell migration involved in sprouting angiogenesis (GO:0002042)2.71103242
138hemidesmosome assembly (GO:0031581)2.70609161
139cell-substrate junction assembly (GO:0007044)2.69914552
140iron ion import (GO:0097286)2.69804188
141ossification (GO:0001503)2.68990949
142negative regulation of cartilage development (GO:0061037)2.68653952
143mesenchyme morphogenesis (GO:0072132)2.68643691
144wound healing (GO:0042060)2.67032106
145regulation of extracellular matrix organization (GO:1903053)2.63757235
146regulation of extracellular matrix disassembly (GO:0010715)2.63673811

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human8.62391683
2TP63_17297297_ChIP-ChIP_HaCaT_Human6.83430433
3RARG_19884340_ChIP-ChIP_MEFs_Mouse5.64098124
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.44224621
5SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.15893604
6CLOCK_20551151_ChIP-Seq_293T_Human2.97575332
7* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.97027281
8* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.91671044
9TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.81497062
10HIF1A_21447827_ChIP-Seq_MCF-7_Human2.80159764
11CJUN_26792858_Chip-Seq_BT549_Human2.73412532
12SMAD_19615063_ChIP-ChIP_OVARY_Human2.65955472
13* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.65776703
14CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.34972294
15ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.34161336
16AR_21572438_ChIP-Seq_LNCaP_Human2.26664140
17SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.19899029
18SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.19899029
19WT1_19549856_ChIP-ChIP_CCG9911_Human2.18199683
20ESR1_21235772_ChIP-Seq_MCF-7_Human2.18169679
21NRF2_20460467_ChIP-Seq_MEFs_Mouse2.16682910
22NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.16682910
23* BRD4_25478319_ChIP-Seq_HGPS_Human2.08010693
24ESR2_21235772_ChIP-Seq_MCF-7_Human2.06585429
25TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.05133910
26* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.97991720
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97988774
28JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.95933786
29JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.90208795
30EP300_21415370_ChIP-Seq_HL-1_Mouse1.81043985
31ELK1_22589737_ChIP-Seq_MCF10A_Human1.76523813
32ATF3_27146783_Chip-Seq_COLON_Human1.75984144
33SOX2_20726797_ChIP-Seq_SW620_Human1.70991070
34SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70066948
35* TP53_18474530_ChIP-ChIP_U2OS_Human1.66164760
36SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.63345710
37ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.62388824
38SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.60787026
39ELK3_25401928_ChIP-Seq_HUVEC_Human1.60731287
40PPAR_26484153_Chip-Seq_NCI-H1993_Human1.54581274
41ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.52981836
42TP53_22127205_ChIP-Seq_IMR90_Human1.52686452
43RNF2_18974828_ChIP-Seq_MESCs_Mouse1.52225505
44EZH2_18974828_ChIP-Seq_MESCs_Mouse1.52225505
45* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.49468419
46WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.47455598
47HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.44840758
48* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.44427896
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.43362237
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.41496753
51ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.41017840
52RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39178258
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37130366
54FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.35594767
55PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35322122
56UBF1/2_26484160_Chip-Seq_HMECs_Human1.35112744
57P300_27058665_Chip-Seq_ZR-75-30cells_Human1.32896916
58TP53_16413492_ChIP-PET_HCT116_Human1.30977199
59* TP53_23651856_ChIP-Seq_MEFs_Mouse1.27856397
60SALL4_18804426_ChIP-ChIP_XEN_Mouse1.26749513
61TP53_20018659_ChIP-ChIP_R1E_Mouse1.26183036
62FOXO3_23340844_ChIP-Seq_DLD1_Human1.24978731
63SMC3_22415368_ChIP-Seq_MEFs_Mouse1.24837731
64SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.24648795
65* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.23999476
66PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.23951383
67GATA2_21666600_ChIP-Seq_HMVEC_Human1.23498061
68MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.22855537
69RXR_22158963_ChIP-Seq_LIVER_Mouse1.22771883
70* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22127326
71RACK7_27058665_Chip-Seq_MCF-7_Human1.19529161
72EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16512427
73* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.15243630
74* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.12486864
75NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.11245801
76KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09555986
77HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09189550
78TBX20_22328084_ChIP-Seq_HEART_Mouse1.08502553
79TBX20_22080862_ChIP-Seq_HEART_Mouse1.08502553
80RXR_22108803_ChIP-Seq_LS180_Human1.07929437
81NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.07506033
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06866917
83SA1_22415368_ChIP-Seq_MEFs_Mouse1.06221930
84NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05045184
85TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00790428
86EED_16625203_ChIP-ChIP_MESCs_Mouse1.00351928
87CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99152058
88ISL1_27105846_Chip-Seq_CPCs_Mouse0.97176017
89* JARID2_20075857_ChIP-Seq_MESCs_Mouse0.96894626
90GATA3_24758297_ChIP-Seq_MCF-7_Human0.96293447
91ESR1_20079471_ChIP-ChIP_T-47D_Human0.95809792
92SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.95266636
93RNF2_27304074_Chip-Seq_ESCs_Mouse0.93994361
94ESR1_15608294_ChIP-ChIP_MCF-7_Human0.93779959
95SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.93668300
96SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.91416625
97PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.91282516
98* PPARD_21283829_ChIP-Seq_MYOFIBROBLAST_Human0.90533250
99ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.90482906
100ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89717157
101FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.89568437
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.88879324
103* LXR_22158963_ChIP-Seq_LIVER_Mouse0.88224732
104RAD21_21589869_ChIP-Seq_MESCs_Mouse0.87967992
105PIAS1_25552417_ChIP-Seq_VCAP_Human0.87881242
106PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.87160170
107* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.86624423
108* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.86258026
109FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86015859
110TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.85562740
111NFI_21473784_ChIP-Seq_ESCs_Mouse0.84554758
112CSB_26484114_Chip-Seq_FIBROBLAST_Human0.84534592
113ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83827631
114EZH2_27304074_Chip-Seq_ESCs_Mouse0.83572338
115TET1_21490601_ChIP-Seq_MESCs_Mouse0.82954326
116PPARA_22158963_ChIP-Seq_LIVER_Mouse0.82933985
117DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.82030358
118TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.81820174
119TBX3_20139965_ChIP-Seq_ESCs_Mouse0.81811295
120TCF3_18692474_ChIP-Seq_MEFs_Mouse0.81780869
121EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.81593549
122TBX3_20139965_ChIP-Seq_MESCs_Mouse0.80949597
123SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.80415503
124* TP63_23658742_ChIP-Seq_EP156T_Human0.75364779
125NFIB_24661679_ChIP-Seq_LUNG_Mouse0.73193064
126TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73023328
127CDX2_19796622_ChIP-Seq_MESCs_Mouse0.72506789
128FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.69373857
129KLF5_25053715_ChIP-Seq_YYC3_Human0.67956803

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.34769839
2MP0005503_abnormal_tendon_morphology4.13566167
3MP0003705_abnormal_hypodermis_morpholog3.88400016
4MP0003279_aneurysm3.74008175
5MP0005275_abnormal_skin_tensile3.63255107
6MP0002282_abnormal_trachea_morphology3.49859152
7MP0004134_abnormal_chest_morphology2.92054091
8MP0002933_joint_inflammation2.80582663
9MP0003566_abnormal_cell_adhesion2.80417192
10MP0005623_abnormal_meninges_morphology2.76100615
11MP0009250_abnormal_appendicular_skeleto2.62952731
12MP0009384_cardiac_valve_regurgitation2.57199943
13MP0004272_abnormal_basement_membrane2.49956155
14MP0000163_abnormal_cartilage_morphology2.48755207
15MP0001958_emphysema2.45913883
16MP0005023_abnormal_wound_healing2.38902806
17MP0005508_abnormal_skeleton_morphology2.26394869
18MP0001299_abnormal_eye_distance/2.21261637
19MP0001542_abnormal_bone_strength2.19909259
20MP0003091_abnormal_cell_migration2.18319130
21MP0010030_abnormal_orbit_morphology2.13896266
22MP0010352_gastrointestinal_tract_polyps2.11142683
23MP0002896_abnormal_bone_mineralization2.08793653
24MP0002115_abnormal_skeleton_extremities1.95470810
25MP0002877_abnormal_melanocyte_morpholog1.81646066
26MP0000013_abnormal_adipose_tissue1.80629738
27MP0009780_abnormal_chondrocyte_physiolo1.79783689
28MP0005390_skeleton_phenotype1.77358276
29MP0002113_abnormal_skeleton_development1.76598803
30MP0008004_abnormal_stomach_pH1.75537785
31MP0000750_abnormal_muscle_regeneration1.70025378
32MP0000762_abnormal_tongue_morphology1.68902342
33MP0001533_abnormal_skeleton_physiology1.63355888
34MP0002089_abnormal_postnatal_growth/wei1.63288209
35MP0006054_spinal_hemorrhage1.60938377
36MP0002060_abnormal_skin_morphology1.52571442
37MP0002295_abnormal_pulmonary_circulatio1.47513291
38MP0003755_abnormal_palate_morphology1.46878602
39MP0010368_abnormal_lymphatic_system1.43734095
40MP0001243_abnormal_dermal_layer1.43389193
41MP0004084_abnormal_cardiac_muscle1.36316552
42MP0003795_abnormal_bone_structure1.34351075
43MP0000751_myopathy1.30927176
44MP0003806_abnormal_nucleotide_metabolis1.29426153
45MP0010386_abnormal_urinary_bladder1.28108757
46MP0003385_abnormal_body_wall1.25590608
47MP0009053_abnormal_anal_canal1.21527910
48MP0000733_abnormal_muscle_development1.20590009
49MP0002108_abnormal_muscle_morphology1.19172267
50MP0000749_muscle_degeneration1.16808113
51MP0002109_abnormal_limb_morphology1.15808522
52MP0005164_abnormal_response_to1.13351185
53MP0005257_abnormal_intraocular_pressure1.12624539
54MP0000343_altered_response_to1.10873686
55MP0000767_abnormal_smooth_muscle1.10152229
56MP0008775_abnormal_heart_ventricle1.07538220
57MP0004858_abnormal_nervous_system1.06704023
58MP0005595_abnormal_vascular_smooth1.04066818
59MP0003942_abnormal_urinary_system1.03961748
60MP0000049_abnormal_middle_ear0.98645592
61MP0001270_distended_abdomen0.98633672
62MP0002998_abnormal_bone_remodeling0.98488320
63MP0002116_abnormal_craniofacial_bone0.98426631
64MP0005171_absent_coat_pigmentation0.95618968
65MP0001348_abnormal_lacrimal_gland0.95570787
66MP0003045_fibrosis0.92737398
67MP0004484_altered_response_of0.92083253
68MP0003950_abnormal_plasma_membrane0.90547138
69MP0002128_abnormal_blood_circulation0.90461875
70MP0005197_abnormal_uvea_morphology0.88236538
71MP0000432_abnormal_head_morphology0.87708218
72MP0003646_muscle_fatigue0.85830872
73MP0006138_congestive_heart_failure0.85390569
74MP0002168_other_aberrant_phenotype0.83572148
75MP0002111_abnormal_tail_morphology0.83160305
76MP0004087_abnormal_muscle_fiber0.82828170
77MP0004233_abnormal_muscle_weight0.82799808
78MP0002932_abnormal_joint_morphology0.82066329
79MP0000003_abnormal_adipose_tissue0.79457175
80MP0005193_abnormal_anterior_eye0.78235247
81MP0003935_abnormal_craniofacial_develop0.78186194
82MP0005330_cardiomyopathy0.78091014
83MP0000759_abnormal_skeletal_muscle0.77952975
84MP0002233_abnormal_nose_morphology0.77697150
85MP0005084_abnormal_gallbladder_morpholo0.76817488
86MP0003941_abnormal_skin_development0.76619251
87MP0001879_abnormal_lymphatic_vessel0.76231945
88MP0002972_abnormal_cardiac_muscle0.75982262
89MP0001614_abnormal_blood_vessel0.75739830
90MP0005620_abnormal_muscle_contractility0.73055276
91MP0001849_ear_inflammation0.71388419
92MP0002909_abnormal_adrenal_gland0.70594189
93MP0005165_increased_susceptibility_to0.70173301
94MP0002249_abnormal_larynx_morphology0.68551953
95MP0002133_abnormal_respiratory_system0.67409624
96MP0005388_respiratory_system_phenotype0.67409624
97MP0003195_calcinosis0.66675303
98MP0002234_abnormal_pharynx_morphology0.66426218
99MP0003937_abnormal_limbs/digits/tail_de0.65134930
100MP0002837_dystrophic_cardiac_calcinosis0.64763775
101MP0000534_abnormal_ureter_morphology0.63285002
102MP0002114_abnormal_axial_skeleton0.62661965
103MP0003123_paternal_imprinting0.62475030
104MP0001175_abnormal_lung_morphology0.58971099
105MP0002925_abnormal_cardiovascular_devel0.58912652
106MP0003448_altered_tumor_morphology0.58354010
107MP0000858_altered_metastatic_potential0.58081722
108MP0003191_abnormal_cellular_cholesterol0.57136609
109MP0004197_abnormal_fetal_growth/weight/0.57016531
110MP0003115_abnormal_respiratory_system0.57004257
111MP0000428_abnormal_craniofacial_morphol0.56556063
112MP0000462_abnormal_digestive_system0.55983244
113MP0003283_abnormal_digestive_organ0.55350392
114MP0001915_intracranial_hemorrhage0.52371813
115MP0000467_abnormal_esophagus_morphology0.49247834
116MP0004036_abnormal_muscle_relaxation0.48952459
117MP0004510_myositis0.48171034
118MP0002177_abnormal_outer_ear0.47310258
119MP0005369_muscle_phenotype0.47247625
120MP0000538_abnormal_urinary_bladder0.46645660
121MP0010771_integument_phenotype0.45537119

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)6.90389090
2Irregular epiphyses (HP:0010582)6.47491178
3Vitreoretinal degeneration (HP:0000655)6.28136853
4Hypoplastic ischia (HP:0003175)5.32214296
5Cupped ribs (HP:0000887)5.17543067
6Protrusio acetabuli (HP:0003179)5.02953389
7Premature rupture of membranes (HP:0001788)4.96187467
8Neonatal short-limb short stature (HP:0008921)4.89789955
9Abnormality of the ischium (HP:0003174)4.68580182
10Flat acetabular roof (HP:0003180)4.61011915
11Vascular tortuosity (HP:0004948)4.54471842
12Aplasia/Hypoplasia of the pubic bone (HP:0009104)4.33912935
13Abnormal tarsal ossification (HP:0008369)4.29908775
14Flat capital femoral epiphysis (HP:0003370)4.14583084
15Bladder diverticulum (HP:0000015)4.13432407
16Broad metatarsal (HP:0001783)4.02226199
17Arterial tortuosity (HP:0005116)4.02206128
18Cervical subluxation (HP:0003308)3.96526064
19Small epiphyses (HP:0010585)3.81411899
20Spondylolisthesis (HP:0003302)3.73569538
21Fragile skin (HP:0001030)3.68249719
22Type 1 muscle fiber predominance (HP:0003803)3.62927731
23Osteoarthritis (HP:0002758)3.60988610
24Coxa vara (HP:0002812)3.58523776
25Abnormal foot bone ossification (HP:0010675)3.54037503
26Slender build (HP:0001533)3.43076830
27Genu varum (HP:0002970)3.36167493
28Flattened epiphyses (HP:0003071)3.33700232
29Delayed epiphyseal ossification (HP:0002663)3.25278354
30Aortic regurgitation (HP:0001659)3.19377628
31Mild short stature (HP:0003502)3.16614586
32Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.14900982
33Abnormality of femoral epiphyses (HP:0006499)3.14900982
34Bowel diverticulosis (HP:0005222)3.12526240
35Arthropathy (HP:0003040)3.10261124
36Mitral valve prolapse (HP:0001634)3.02325867
37Beaking of vertebral bodies (HP:0004568)2.98864848
38Metaphyseal cupping (HP:0003021)2.97770139
39Absent epiphyses (HP:0010577)2.96562968
40Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.96562968
41Hyperextensible skin (HP:0000974)2.96252421
42Platyspondyly (HP:0000926)2.91980193
43Abnormality of the proximal phalanges of the hand (HP:0009834)2.85730609
44Protuberant abdomen (HP:0001538)2.84968994
45Abnormal vertebral ossification (HP:0100569)2.82696824
46Abnormality of the vertebral endplates (HP:0005106)2.82595270
47Vertebral compression fractures (HP:0002953)2.81416048
48Mitral regurgitation (HP:0001653)2.79179883
49Joint laxity (HP:0001388)2.75647742
50Aortic dissection (HP:0002647)2.72971516
51Mitral stenosis (HP:0001718)2.72085566
52Thoracolumbar scoliosis (HP:0002944)2.70959564
53Abnormality of the acetabulum (HP:0003170)2.70130626
54Wrist flexion contracture (HP:0001239)2.69977387
55Absent frontal sinuses (HP:0002688)2.67643535
56Spinal rigidity (HP:0003306)2.65311048
57Abnormality of the epiphysis of the femoral head (HP:0010574)2.65062282
58Cerebral aneurysm (HP:0004944)2.63888850
59Osteolytic defects of the phalanges of the hand (HP:0009771)2.63284861
60Osteolytic defects of the hand bones (HP:0009699)2.63284861
61Atrophic scars (HP:0001075)2.62792649
62Abnormal delivery (HP:0001787)2.62575036
63Thin ribs (HP:0000883)2.60637516
64Round ear (HP:0100830)2.57820041
65Abnormality of dentin (HP:0010299)2.55628906
66Short femoral neck (HP:0100864)2.55590633
67Stillbirth (HP:0003826)2.55195873
68Coronal craniosynostosis (HP:0004440)2.54887747
69Aortic valve stenosis (HP:0001650)2.54743956
70Wormian bones (HP:0002645)2.52873522
71Increased connective tissue (HP:0009025)2.52671950
72Aortic aneurysm (HP:0004942)2.48659197
73Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.45446975
74Vertebral hypoplasia (HP:0008417)2.45446975
75Abnormality of carpal bone ossification (HP:0006257)2.45071336
76Limited elbow extension (HP:0001377)2.45028505
77Radial bowing (HP:0002986)2.44253468
78Elbow flexion contracture (HP:0002987)2.44124137
79Abnormality of the phalanges of the 2nd finger (HP:0009541)2.43162681
80Ulnar bowing (HP:0003031)2.40628402
81Mesomelia (HP:0003027)2.40573278
82Abnormality of the femoral head (HP:0003368)2.39795810
83Cardiovascular calcification (HP:0011915)2.39303559
84Spinal cord compression (HP:0002176)2.38644527
85Fibular hypoplasia (HP:0003038)2.38557322
86Increased variability in muscle fiber diameter (HP:0003557)2.37418467
87Irregular vertebral endplates (HP:0003301)2.33652395
88Biconcave vertebral bodies (HP:0004586)2.32486837
89Mildly elevated creatine phosphokinase (HP:0008180)2.31829489
90Ovoid vertebral bodies (HP:0003300)2.30850231
91Abnormality of the pubic bones (HP:0003172)2.30173690
92Short nail (HP:0001799)2.29929383
93Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.29160738
94Joint stiffness (HP:0001387)2.27693849
95Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.27639438
96Aneurysm (HP:0002617)2.26814009
97Peritonitis (HP:0002586)2.26617144
98Ectopia lentis (HP:0001083)2.26266714
99Waddling gait (HP:0002515)2.26216232
100Dilatation of the ascending aorta (HP:0005111)2.25434281
101Metaphyseal irregularity (HP:0003025)2.24683150
102Abnormality of the 2nd finger (HP:0004100)2.24418230
103Nonimmune hydrops fetalis (HP:0001790)2.23997024
104Hypoventilation (HP:0002791)2.23644656
105Exostoses (HP:0100777)2.23455819
106Hypoplasia of the odontoid process (HP:0003311)2.22132087
107Soft skin (HP:0000977)2.18718930
108Glossoptosis (HP:0000162)2.18355116
109Hip contracture (HP:0003273)2.17881546
110Blue sclerae (HP:0000592)2.17752539
111Lumbar hyperlordosis (HP:0002938)2.17280476
112Abnormal ossification of hand bones (HP:0005921)2.15898203
113Shallow orbits (HP:0000586)2.14885306
114Ankle contracture (HP:0006466)2.13954893
115Limited hip movement (HP:0008800)2.12899286
116Redundant skin (HP:0001582)2.10694061
117Genu recurvatum (HP:0002816)2.10557318
118Entropion (HP:0000621)2.09621367
119Vertebral clefting (HP:0008428)2.08626428
120Abnormality of the odontoid process (HP:0003310)2.07979740
121Delayed gross motor development (HP:0002194)2.07205918
122Broad ribs (HP:0000885)2.06611491
123Camptodactyly of toe (HP:0001836)2.05851681
124Breech presentation (HP:0001623)2.05546290
125Deviation of the hallux (HP:0010051)2.05285218
126Delayed cranial suture closure (HP:0000270)2.04981890
127Hallux valgus (HP:0001822)2.04971911
128Aplasia/hypoplasia of the femur (HP:0005613)2.04908291
129Broad long bones (HP:0005622)2.04164766
130Delayed closure of the anterior fontanelle (HP:0001476)2.03761649
131Disproportionate tall stature (HP:0001519)2.02569633
132Abnormality of the calcaneus (HP:0008364)2.01237889
133Hypoplasia of the iris (HP:0007676)2.00609233
134Abnormality of skeletal muscle fiber size (HP:0012084)1.99865173
135Abnormal cartilage morphology (HP:0002763)1.98022720
136Overgrowth (HP:0001548)1.96749596
137Reduced subcutaneous adipose tissue (HP:0003758)1.96684161
138Distal lower limb muscle weakness (HP:0009053)1.95634921
139Generalized amyotrophy (HP:0003700)1.95185784
140Metaphyseal dysplasia (HP:0100255)1.94964673
141Disproportionate short-trunk short stature (HP:0003521)1.93939734
142Follicular hyperkeratosis (HP:0007502)1.93240367
143Natal tooth (HP:0000695)1.93190438
144Thin bony cortex (HP:0002753)1.92820558
145Broad phalanx (HP:0006009)1.92162232
146Congenital glaucoma (HP:0001087)1.91443959
147Infantile muscular hypotonia (HP:0008947)1.91383847
148Flared iliac wings (HP:0002869)1.91286746
149Wide anterior fontanel (HP:0000260)1.91222787
150Barrel-shaped chest (HP:0001552)1.90575635
151Spinal cord lesions (HP:0100561)1.89276465
152Syringomyelia (HP:0003396)1.89276465
153Renal duplication (HP:0000075)1.88630278
154Inguinal hernia (HP:0000023)1.86087071
155Abnormality of skull ossification (HP:0002703)1.80609205
156Knee flexion contracture (HP:0006380)1.80504593
157Distal upper limb amyotrophy (HP:0007149)1.78974176
158Upper limb amyotrophy (HP:0009129)1.78974176
159Persistence of primary teeth (HP:0006335)1.78248105
160Bell-shaped thorax (HP:0001591)1.76628534
161Achilles tendon contracture (HP:0001771)1.73697458
162Flat cornea (HP:0007720)1.72417387
163Protruding ear (HP:0000411)1.72331800
164Buphthalmos (HP:0000557)1.72105397
165Venous abnormality (HP:0002624)1.69170651

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR25.07102393
2MAP3K34.62700822
3TTN3.78872670
4EPHA23.34486418
5TESK13.17775551
6STK38L3.11327966
7TRIB32.72888297
8LIMK12.70724395
9LATS22.53426965
10PIM22.42096200
11LATS12.25186077
12NTRK12.20536331
13ERBB32.09804436
14TRPM71.98680734
15NME11.93053656
16NME21.87959688
17ERN11.79712455
18PAK21.77909105
19TAOK11.74751593
20PRKG21.73083688
21TAOK21.71979670
22PDGFRA1.67211577
23RPS6KA41.66937655
24MYLK1.61036326
25EPHB21.56602834
26STK381.54582025
27PKN21.54180307
28PIK3CG1.50674346
29PIK3CA1.50287378
30MAP3K111.49000898
31PTK21.48216882
32PTK2B1.47706529
33BMX1.46708564
34MOS1.42626382
35MET1.42554930
36ERBB41.35223365
37ROCK11.29567300
38STK241.26742355
39PAK31.23567883
40MAP3K121.22530739
41PRKD31.18218474
42NEK91.14570398
43PLK21.12301754
44MAP2K31.10825928
45MAP3K61.10746811
46PDK21.05615376
47FER1.05075551
48MAPKAPK31.04297961
49ICK1.01383723
50FLT31.00867155
51DMPK1.00106304
52STK30.99166218
53SIK10.98527108
54LRRK20.97799426
55TESK20.96098243
56MST1R0.95245367
57WNK10.93010904
58ARAF0.88424987
59KIT0.86204839
60AKT30.83871340
61RPS6KA20.81894850
62MAP2K10.81566843
63DAPK30.78399346
64ILK0.75559606
65PTK60.72566054
66ABL20.69498435
67CAMK2G0.67312515
68MELK0.64677862
69CDK80.64062749
70EIF2AK10.63464661
71CDC42BPA0.61647728
72PAK40.57154778
73FGFR10.53879742
74MST40.51171082
75EIF2AK30.50939747
76PAK10.50520096
77CAMKK20.50177734
78CLK10.50022710
79NUAK10.49716478
80MTOR0.49387804
81CAMK2B0.48429971
82KDR0.47829154
83PAK60.47602120
84GRK70.47163491
85PRKD10.46968747
86ROCK20.46872005
87INSR0.45557032
88MAP3K50.43569314
89MKNK10.42857240
90MAPK120.42112120
91CDK140.41512341
92PDGFRB0.41320496
93RIPK10.39426049
94IRAK30.39281897
95SMG10.38364167
96GSK3A0.37788739
97CAMKK10.37255827
98EPHA30.37100135
99CAMK2D0.36720778
100CDK90.34757034
101STK100.34197819
102PRKD20.32778921
103MAPK70.30900900
104CDK150.30563231
105FRK0.30078028
106STK40.29430899
107LMTK20.29390984
108TGFBR20.29129639
109CDK180.28962843
110PRPF4B0.28081957
111RPS6KL10.27982936
112RPS6KC10.27982936
113RPS6KB20.27838968
114PDK30.27222366
115PDK40.27222366
116BUB10.27166108
117PRKCH0.25821467
118EPHB10.25470522
119TYK20.24895091
120PRKCE0.24742580
121MAPK40.24706510
122MAP3K80.24395648
123CDK70.24022333
124SRC0.23131035
125CDK11A0.22987981
126ZAK0.22858268
127MAPKAPK20.22699853
128ADRBK10.22341753
129PRKCI0.20913408
130RET0.19847060
131JAK10.18186768

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045125.39869753
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005325.39153860
3Protein digestion and absorption_Homo sapiens_hsa049743.47949660
4Focal adhesion_Homo sapiens_hsa045103.19923446
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.40684878
6Bladder cancer_Homo sapiens_hsa052192.39509630
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.31820916
8Proteoglycans in cancer_Homo sapiens_hsa052052.27317400
9Dilated cardiomyopathy_Homo sapiens_hsa054142.13161213
10Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.12613899
11TGF-beta signaling pathway_Homo sapiens_hsa043501.93506864
12Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.86550145
13Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.79913213
14Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.79223808
15Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.77974489
16Malaria_Homo sapiens_hsa051441.75295925
17* PI3K-Akt signaling pathway_Homo sapiens_hsa041511.60409923
18Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.58552960
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.57930206
20Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.52718444
21Amoebiasis_Homo sapiens_hsa051461.51478240
22Hippo signaling pathway_Homo sapiens_hsa043901.46115180
23Sulfur metabolism_Homo sapiens_hsa009201.38812117
24Vibrio cholerae infection_Homo sapiens_hsa051101.38351965
25Adherens junction_Homo sapiens_hsa045201.34657306
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.30896724
27Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.29975511
28Phagosome_Homo sapiens_hsa041451.29177000
29Shigellosis_Homo sapiens_hsa051311.27832106
30Small cell lung cancer_Homo sapiens_hsa052221.24556610
31Complement and coagulation cascades_Homo sapiens_hsa046101.21917234
32MicroRNAs in cancer_Homo sapiens_hsa052061.21174147
33Melanogenesis_Homo sapiens_hsa049161.15298546
34Regulation of actin cytoskeleton_Homo sapiens_hsa048101.13416660
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.11546240
36Axon guidance_Homo sapiens_hsa043601.07787628
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07572130
38Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.07044983
39Starch and sucrose metabolism_Homo sapiens_hsa005001.06401616
40Melanoma_Homo sapiens_hsa052181.05697759
41p53 signaling pathway_Homo sapiens_hsa041151.02251541
42Pentose and glucuronate interconversions_Homo sapiens_hsa000400.98244600
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95997629
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.92738892
45Wnt signaling pathway_Homo sapiens_hsa043100.91136970
46Steroid biosynthesis_Homo sapiens_hsa001000.87514157
47HIF-1 signaling pathway_Homo sapiens_hsa040660.87175510
48Arginine and proline metabolism_Homo sapiens_hsa003300.87111230
49Endocytosis_Homo sapiens_hsa041440.81641270
50Selenocompound metabolism_Homo sapiens_hsa004500.79850264
51TNF signaling pathway_Homo sapiens_hsa046680.79514455
52Phospholipase D signaling pathway_Homo sapiens_hsa040720.79367189
53Arginine biosynthesis_Homo sapiens_hsa002200.77445406
54Prion diseases_Homo sapiens_hsa050200.70124975
55Sphingolipid metabolism_Homo sapiens_hsa006000.70043329
56Cocaine addiction_Homo sapiens_hsa050300.69100013
57Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68331912
58Lysosome_Homo sapiens_hsa041420.68160900
59Chemical carcinogenesis_Homo sapiens_hsa052040.68024628
60Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.66157645
61Gap junction_Homo sapiens_hsa045400.64611502
62Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.63723283
63Tight junction_Homo sapiens_hsa045300.62626917
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61852402
65One carbon pool by folate_Homo sapiens_hsa006700.59760934
66Biosynthesis of amino acids_Homo sapiens_hsa012300.59566265
67* Rap1 signaling pathway_Homo sapiens_hsa040150.58246391
68Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56910214
69* Ras signaling pathway_Homo sapiens_hsa040140.54752783
70Platelet activation_Homo sapiens_hsa046110.54665066
71Glutathione metabolism_Homo sapiens_hsa004800.52684779
72Leukocyte transendothelial migration_Homo sapiens_hsa046700.51982017
73Ovarian steroidogenesis_Homo sapiens_hsa049130.51544354
74GnRH signaling pathway_Homo sapiens_hsa049120.51524209
75Dorso-ventral axis formation_Homo sapiens_hsa043200.51410932
76Chronic myeloid leukemia_Homo sapiens_hsa052200.51221368
77Carbon metabolism_Homo sapiens_hsa012000.49732005
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49223785
79SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48121568
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.48032308
81Glioma_Homo sapiens_hsa052140.47475119
82mTOR signaling pathway_Homo sapiens_hsa041500.47049215
83Pertussis_Homo sapiens_hsa051330.46592685
84Pyruvate metabolism_Homo sapiens_hsa006200.45812974
85Thyroid cancer_Homo sapiens_hsa052160.45483264
86* MAPK signaling pathway_Homo sapiens_hsa040100.45365339
87Basal cell carcinoma_Homo sapiens_hsa052170.45167408
88Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.44834164
89Protein export_Homo sapiens_hsa030600.44697237
90Hepatitis B_Homo sapiens_hsa051610.44661312
91HTLV-I infection_Homo sapiens_hsa051660.44368764
92AMPK signaling pathway_Homo sapiens_hsa041520.44354972
93Longevity regulating pathway - mammal_Homo sapiens_hsa042110.43817794
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.42948180
95Estrogen signaling pathway_Homo sapiens_hsa049150.42566860
96Renin secretion_Homo sapiens_hsa049240.42551522
97Central carbon metabolism in cancer_Homo sapiens_hsa052300.42524883
98Hedgehog signaling pathway_Homo sapiens_hsa043400.42203344
99Salmonella infection_Homo sapiens_hsa051320.41566000
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41330887
101Prostate cancer_Homo sapiens_hsa052150.40216627
102Pathways in cancer_Homo sapiens_hsa052000.39887772
103Viral myocarditis_Homo sapiens_hsa054160.38795158
104PPAR signaling pathway_Homo sapiens_hsa033200.38780285
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.37691679
106Cysteine and methionine metabolism_Homo sapiens_hsa002700.36893149
107Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.36391636
108N-Glycan biosynthesis_Homo sapiens_hsa005100.35790731
109Rheumatoid arthritis_Homo sapiens_hsa053230.35731075
110* Neurotrophin signaling pathway_Homo sapiens_hsa047220.35598656
111Gastric acid secretion_Homo sapiens_hsa049710.35264029
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.34978036
113ErbB signaling pathway_Homo sapiens_hsa040120.34977878
114Pancreatic cancer_Homo sapiens_hsa052120.33889268
115Calcium signaling pathway_Homo sapiens_hsa040200.33557018
116Endometrial cancer_Homo sapiens_hsa052130.33142289
117Renal cell carcinoma_Homo sapiens_hsa052110.32926784
118Renin-angiotensin system_Homo sapiens_hsa046140.32889670
119Thyroid hormone synthesis_Homo sapiens_hsa049180.32782242
120Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.32267416
121Glucagon signaling pathway_Homo sapiens_hsa049220.32103126
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.30616766
123Insulin secretion_Homo sapiens_hsa049110.30293930
124Vascular smooth muscle contraction_Homo sapiens_hsa042700.30046069
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.29671178
126Arachidonic acid metabolism_Homo sapiens_hsa005900.29214880
127VEGF signaling pathway_Homo sapiens_hsa043700.28582261
128Viral carcinogenesis_Homo sapiens_hsa052030.28554694
129Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.28551681
130Oxytocin signaling pathway_Homo sapiens_hsa049210.28349259
131Primary bile acid biosynthesis_Homo sapiens_hsa001200.28022909
132Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27986318
133Phenylalanine metabolism_Homo sapiens_hsa003600.27099505
134Galactose metabolism_Homo sapiens_hsa000520.26495485
135Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26091372
136cGMP-PKG signaling pathway_Homo sapiens_hsa040220.24459566
137Legionellosis_Homo sapiens_hsa051340.23855098
138Toxoplasmosis_Homo sapiens_hsa051450.23814012
139Other glycan degradation_Homo sapiens_hsa005110.23450110

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