NGFR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Nerve growth factor receptor contains an extracellular domain containing four 40-amino acid repeats with 6 cysteine residues at conserved positions followed by a serine/threonine-rich region, a single transmembrane domain, and a 155-amino acid cytoplasmic domain. The cysteine-rich region contains the nerve growth factor binding domain. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)9.83912093
2doxorubicin metabolic process (GO:0044598)9.83912093
3daunorubicin metabolic process (GO:0044597)9.83912093
4aminoglycoside antibiotic metabolic process (GO:0030647)6.21844579
5maintenance of protein location in nucleus (GO:0051457)6.17215503
6regulation of mammary gland epithelial cell proliferation (GO:0033599)6.10115403
7phenol-containing compound catabolic process (GO:0019336)5.97795054
8negative regulation of catenin import into nucleus (GO:0035414)5.88243325
9somite rostral/caudal axis specification (GO:0032525)5.82282523
10negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)5.73860942
11proline transport (GO:0015824)5.59932831
12negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)5.48959523
13muscle organ morphogenesis (GO:0048644)5.41409172
14muscle cell fate commitment (GO:0042693)5.35184490
15neurofilament cytoskeleton organization (GO:0060052)5.21343320
16detection of temperature stimulus involved in sensory perception of pain (GO:0050965)5.19270464
17detection of temperature stimulus involved in sensory perception (GO:0050961)5.19270464
18regulation of response to osmotic stress (GO:0047484)5.18901764
19negative regulation of cell cycle G2/M phase transition (GO:1902750)5.05419328
20histone H4-K5 acetylation (GO:0043981)5.02648562
21histone H4-K8 acetylation (GO:0043982)5.02648562
22negative regulation of telomerase activity (GO:0051974)4.86643059
23cytidine deamination (GO:0009972)4.72074385
24cytidine metabolic process (GO:0046087)4.72074385
25cytidine catabolic process (GO:0006216)4.72074385
26regulation of MHC class I biosynthetic process (GO:0045343)4.68711980
27protein localization to kinetochore (GO:0034501)4.68375589
28response to inactivity (GO:0014854)4.68208067
29notochord development (GO:0030903)4.64638619
30response to dietary excess (GO:0002021)4.62234987
31rRNA transcription (GO:0009303)4.58846286
32regulation of telomere maintenance via telomerase (GO:0032210)4.57482462
33planar cell polarity pathway involved in neural tube closure (GO:0090179)4.54676810
34regulation of nuclear cell cycle DNA replication (GO:0033262)4.52277129
35histone H4-K12 acetylation (GO:0043983)4.49534824
36* detection of temperature stimulus (GO:0016048)4.45965986
37regulation of cilium movement (GO:0003352)4.43166602
38negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.42928396
39negative regulation of epidermal cell differentiation (GO:0045605)4.42786538
40cell migration in hindbrain (GO:0021535)4.35971614
41protein polyglutamylation (GO:0018095)4.26286543
42hormone catabolic process (GO:0042447)4.22696439
43regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.20694889
44coenzyme catabolic process (GO:0009109)4.18909256
45heterochromatin organization (GO:0070828)4.18711902
46paraxial mesoderm development (GO:0048339)4.18296666
47calcium-mediated signaling using intracellular calcium source (GO:0035584)4.15844507
48negative regulation of potassium ion transmembrane transport (GO:1901380)4.02007803
49response to water (GO:0009415)3.96716477
50convergent extension (GO:0060026)3.85514772
51mitotic sister chromatid segregation (GO:0000070)3.84500644
52primitive streak formation (GO:0090009)3.84173800
53* negative regulation of epidermis development (GO:0045683)3.81323946
54nucleoside transmembrane transport (GO:1901642)3.80749673
55pyrimidine ribonucleoside catabolic process (GO:0046133)3.79410689
56branching involved in mammary gland duct morphogenesis (GO:0060444)3.79066143
57regulation of microtubule-based movement (GO:0060632)3.77819875
58synaptic vesicle maturation (GO:0016188)3.77798953
59histone H4-K16 acetylation (GO:0043984)3.63954685
60vitamin A metabolic process (GO:0006776)3.59983179
61negative regulation of chondrocyte differentiation (GO:0032331)3.55168361
62bone trabecula formation (GO:0060346)3.52357960
63cellular modified amino acid catabolic process (GO:0042219)3.50122701
64positive regulation of DNA-dependent DNA replication (GO:2000105)3.45034913
65mitochondrion distribution (GO:0048311)3.44576830
66cell fate commitment involved in formation of primary germ layer (GO:0060795)3.44058655
67regulation of apoptotic process involved in morphogenesis (GO:1902337)3.42622594
68skeletal muscle fiber development (GO:0048741)3.38981825
69Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.38093877
70quinone metabolic process (GO:1901661)3.36704708
71enteric nervous system development (GO:0048484)3.34955325
72negative regulation of telomere maintenance (GO:0032205)3.34280968
73maintenance of protein localization in organelle (GO:0072595)3.34233463
74rRNA methylation (GO:0031167)3.32765514
75myoblast fusion (GO:0007520)3.32366579
76interferon-gamma production (GO:0032609)3.32308041
77cullin deneddylation (GO:0010388)3.30228146
78peripheral nervous system axon ensheathment (GO:0032292)3.30075711
79myelination in peripheral nervous system (GO:0022011)3.30075711
80chromatin assembly (GO:0031497)3.29056229
81intestinal epithelial cell development (GO:0060576)3.28701706
82regulation of telomerase activity (GO:0051972)3.26559904
83semaphorin-plexin signaling pathway (GO:0071526)3.26047998
84endocardial cushion morphogenesis (GO:0003203)3.25084011
85microtubule severing (GO:0051013)3.24882108
86epoxygenase P450 pathway (GO:0019373)3.23669671
87cardiovascular system development (GO:0072358)3.22906884
88regulation of establishment of planar polarity (GO:0090175)3.22478053
89nuclear pore complex assembly (GO:0051292)3.21978511
90hypotonic response (GO:0006971)3.21832613
91retinoic acid receptor signaling pathway (GO:0048384)3.21450012
92branching involved in salivary gland morphogenesis (GO:0060445)3.19871435
93neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.19770859
94DNA replication-dependent nucleosome assembly (GO:0006335)3.19531466
95DNA replication-dependent nucleosome organization (GO:0034723)3.19531466
96neuron projection extension involved in neuron projection guidance (GO:1902284)3.19222939
97axon extension involved in axon guidance (GO:0048846)3.19222939
98regulation of translation in response to stress (GO:0043555)3.18736911
99regulation of intracellular estrogen receptor signaling pathway (GO:0033146)3.17113086
100cochlea morphogenesis (GO:0090103)3.16592048
101positive regulation of myotube differentiation (GO:0010831)3.15195530
102arachidonic acid secretion (GO:0050482)3.15080152
103icosanoid secretion (GO:0032309)3.15080152
104sister chromatid segregation (GO:0000819)3.12996772
105myotube differentiation (GO:0014902)3.12466529
106regulation of cardiac muscle cell apoptotic process (GO:0010665)3.11033227
107protein localization to chromosome, centromeric region (GO:0071459)3.10398410
108muscle filament sliding (GO:0030049)3.09983263
109actin-myosin filament sliding (GO:0033275)3.09983263
110mesenchyme morphogenesis (GO:0072132)3.08904578
111response to muscle activity (GO:0014850)3.08144803
112negative regulation of cartilage development (GO:0061037)3.04832437
113pre-miRNA processing (GO:0031054)3.04814302
114syncytium formation by plasma membrane fusion (GO:0000768)3.03510095
115neuromuscular synaptic transmission (GO:0007274)3.01974381
116mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.01853064
117mitochondrion transport along microtubule (GO:0047497)2.99487860
118establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.99487860
119intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)2.99136258
120negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.97899877
121sympathetic nervous system development (GO:0048485)2.97684717
122outer ear morphogenesis (GO:0042473)2.96820126
123positive regulation of protein deacetylation (GO:0090312)2.95527495
124atrioventricular valve morphogenesis (GO:0003181)2.94014418
125basement membrane organization (GO:0071711)2.92995131
126hemidesmosome assembly (GO:0031581)2.90148826
127omega-hydroxylase P450 pathway (GO:0097267)2.89766567
128postsynaptic membrane organization (GO:0001941)2.85929391
129cell-cell junction maintenance (GO:0045217)2.85888810
130regulation of catenin import into nucleus (GO:0035412)2.85733143
131viral transcription (GO:0019083)2.85160960
132myotube cell development (GO:0014904)2.84995610
133apoptotic DNA fragmentation (GO:0006309)2.83174332
134digestive tract morphogenesis (GO:0048546)2.82649700
135regulation of telomere maintenance (GO:0032204)2.82623822
136rRNA modification (GO:0000154)2.82064722
137glucocorticoid biosynthetic process (GO:0006704)2.81510525
138metanephric mesenchyme development (GO:0072075)2.81362820
139positive regulation of axon extension (GO:0045773)2.81299988
140protein deneddylation (GO:0000338)2.79123970
141cell migration involved in heart development (GO:0060973)2.79094914
142peristalsis (GO:0030432)2.78501921
143cardiac myofibril assembly (GO:0055003)2.78225804
144response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.77689473
145GDP-mannose metabolic process (GO:0019673)2.77440256
146anterior/posterior axis specification (GO:0009948)2.75201188
147cranial nerve morphogenesis (GO:0021602)2.74971985
148establishment of mitochondrion localization (GO:0051654)2.74263267
149tachykinin receptor signaling pathway (GO:0007217)2.73437700
150response to gravity (GO:0009629)2.73383071
151non-canonical Wnt signaling pathway (GO:0035567)2.73074557
152glomerulus development (GO:0032835)2.72379003
153facial nerve structural organization (GO:0021612)2.70647859
154locomotory exploration behavior (GO:0035641)2.67666604
155endothelial cell chemotaxis (GO:0035767)2.67568268
156regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.65659548
157muscle cell cellular homeostasis (GO:0046716)2.64985516
158translational termination (GO:0006415)2.64160631
159actin-mediated cell contraction (GO:0070252)2.64053561
160regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.58023646
161endothelial cell morphogenesis (GO:0001886)2.57752732
162syncytium formation (GO:0006949)2.57432160
163short-term memory (GO:0007614)2.55753443
164plasma membrane repair (GO:0001778)2.55625322
165urogenital system development (GO:0001655)2.55613410
166dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.53986117
167cell aggregation (GO:0098743)2.53709009
168cartilage condensation (GO:0001502)2.53709009
169epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.53247318
170kidney mesenchyme development (GO:0072074)2.51163969
171cell proliferation involved in metanephros development (GO:0072203)2.50540277
172peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.49755611
173G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.47639390
174auditory behavior (GO:0031223)2.46796950
175skeletal muscle organ development (GO:0060538)2.44595509
176axon extension (GO:0048675)2.42791625
177ganglion development (GO:0061548)2.41589269
178positive regulation of skeletal muscle tissue development (GO:0048643)2.40381165
179embryonic skeletal system morphogenesis (GO:0048704)2.40122265
180chondrocyte proliferation (GO:0035988)2.37482268
181regulation of axon extension involved in axon guidance (GO:0048841)2.36818835
182hippo signaling (GO:0035329)2.36580657
183camera-type eye morphogenesis (GO:0048593)2.36464747
184neuromuscular junction development (GO:0007528)2.35892220
185muscle organ development (GO:0007517)2.34832821
186skeletal muscle tissue development (GO:0007519)2.34414218
187muscle structure development (GO:0061061)2.33700884
188neural crest cell migration (GO:0001755)2.33369179
189lung epithelium development (GO:0060428)2.33265837
190positive regulation of myoblast differentiation (GO:0045663)2.32832226
191negative regulation of catecholamine secretion (GO:0033604)2.32414388
192regulation of non-canonical Wnt signaling pathway (GO:2000050)2.30917482
193regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.29188600
194cranial nerve structural organization (GO:0021604)2.28851318
195apical protein localization (GO:0045176)2.28022984

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.72780879
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.72780879
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.72780879
4BP1_19119308_ChIP-ChIP_Hs578T_Human5.81727101
5TP63_17297297_ChIP-ChIP_HaCaT_Human4.96358067
6NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.42779221
7NACC1_18358816_ChIP-ChIP_MESCs_Mouse3.39716569
8SMAD3_22036565_ChIP-Seq_ESCs_Mouse3.20559961
9SOX2_18358816_ChIP-ChIP_MESCs_Mouse3.20400247
10* POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.92002519
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.89620617
12* NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.81326376
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.78324080
14SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.74244117
15TP63_19390658_ChIP-ChIP_HaCaT_Human2.68147447
16EZH2_22144423_ChIP-Seq_EOC_Human2.65986140
17THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.65599402
18TCF3_18692474_ChIP-Seq_MESCs_Mouse2.60905442
19ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.48048864
20MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.45708916
21RBPJ_22232070_ChIP-Seq_NCS_Mouse2.38637085
22NANOG_18347094_ChIP-ChIP_MESCs_Mouse2.36781429
23TCF3_18692474_ChIP-Seq_MEFs_Mouse2.36116557
24* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.25229981
25EZH2_27304074_Chip-Seq_ESCs_Mouse2.22511576
26EED_16625203_ChIP-ChIP_MESCs_Mouse2.21250680
27ZFP281_18757296_ChIP-ChIP_E14_Mouse2.12608710
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.12359641
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.08679161
30* KLF4_18358816_ChIP-ChIP_MESCs_Mouse2.08298353
31NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.08150358
32ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.02994739
33NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.02869902
34SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.02725456
35CLOCK_20551151_ChIP-Seq_293T_Human1.99874334
36TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.95673094
37SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95401820
38SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.94762406
39* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.93357662
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.91162466
41EZH2_27294783_Chip-Seq_ESCs_Mouse1.90847316
42PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.89235578
43PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.88650336
44CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.82916689
45POU5F1_16518401_ChIP-PET_MESCs_Mouse1.79147478
46HIF1A_21447827_ChIP-Seq_MCF-7_Human1.78281286
47EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.78007222
48JARID2_20064375_ChIP-Seq_MESCs_Mouse1.70251299
49ZFP281_27345836_Chip-Seq_ESCs_Mouse1.68682445
50* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.66756622
51NFIB_24661679_ChIP-Seq_LUNG_Mouse1.62760400
52* PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.60430301
53* RING1B_27294783_Chip-Seq_ESCs_Mouse1.58965631
54NANOG_18692474_ChIP-Seq_MESCs_Mouse1.57694237
55CTCF_27219007_Chip-Seq_Bcells_Human1.57152661
56RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.55101612
57POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.54955481
58SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.54930571
59* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.52561579
60NANOG_18692474_ChIP-Seq_MEFs_Mouse1.51910939
61ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.49195536
62ISL1_27105846_Chip-Seq_CPCs_Mouse1.47472798
63* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.46496125
64DNAJC2_21179169_ChIP-ChIP_NT2_Human1.39410406
65CBX2_27304074_Chip-Seq_ESCs_Mouse1.37492123
66* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.37450580
67* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.35570212
68TP53_20018659_ChIP-ChIP_R1E_Mouse1.34510466
69* KDM2B_26808549_Chip-Seq_K562_Human1.34473518
70* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.34055703
71E2F1_17053090_ChIP-ChIP_MCF-7_Human1.34033921
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.33478841
73IRF1_19129219_ChIP-ChIP_H3396_Human1.32232918
74SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.31796485
75NANOG_16518401_ChIP-PET_MESCs_Mouse1.30402225
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.29209025
77SOX2_18692474_ChIP-Seq_MESCs_Mouse1.28299925
78ERG_21242973_ChIP-ChIP_JURKAT_Human1.27540556
79RNF2_27304074_Chip-Seq_NSC_Mouse1.27163202
80STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25850402
81IKZF1_21737484_ChIP-ChIP_HCT116_Human1.25599785
82RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24781363
83CDX2_20551321_ChIP-Seq_CACO-2_Human1.24234633
84DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.24207802
85POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23695734
86* RING1B_27294783_Chip-Seq_NPCs_Mouse1.20911781
87POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.20488666
88IGF1R_20145208_ChIP-Seq_DFB_Human1.20136220
89TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.20056552
90* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.18998097
91TET1_21451524_ChIP-Seq_MESCs_Mouse1.18758398
92STAT6_21828071_ChIP-Seq_BEAS2B_Human1.18724276
93E2F7_22180533_ChIP-Seq_HELA_Human1.18349944
94TBX3_20139965_ChIP-Seq_MESCs_Mouse1.16668833
95TBX3_20139965_ChIP-Seq_ESCs_Mouse1.16203332
96* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15875158
97TP53_22127205_ChIP-Seq_IMR90_Human1.15306107
98* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.15040739
99* OCT4_18692474_ChIP-Seq_MEFs_Mouse1.14574642
100SOX2_18692474_ChIP-Seq_MEFs_Mouse1.14554173
101RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13180206
102* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.11836075
103SOX2_18555785_ChIP-Seq_MESCs_Mouse1.11131009
104CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.10659993
105* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10022738
106* SMC3_22415368_ChIP-Seq_MEFs_Mouse1.09832246
107TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09420626
108RNF2_18974828_ChIP-Seq_MESCs_Mouse1.08896108
109EZH2_18974828_ChIP-Seq_MESCs_Mouse1.08896108
110DROSHA_22980978_ChIP-Seq_HELA_Human1.08353179
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07647366
112PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.05910394
113EP300_21415370_ChIP-Seq_HL-1_Mouse1.05845517
114GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04830287
115* TP53_23651856_ChIP-Seq_MEFs_Mouse1.02246152
116WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01650639
117CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.01617701
118TBX20_22328084_ChIP-Seq_HEART_Mouse1.00474826
119TBX20_22080862_ChIP-Seq_HEART_Mouse1.00474826
120WT1_19549856_ChIP-ChIP_CCG9911_Human0.99270225
121ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98021490
122TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.97182823
123NANOG_16153702_ChIP-ChIP_HESCs_Human0.96371055
124* SA1_22415368_ChIP-Seq_MEFs_Mouse0.96334379
125PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.96224994
126TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96152939
127SMC4_20622854_ChIP-Seq_HELA_Human0.95196488
128* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.91438862
129NANOG_21062744_ChIP-ChIP_HESCs_Human0.90383631
130TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89840229
131LXR_22292898_ChIP-Seq_THP-1_Human0.89727553
132SA1_27219007_Chip-Seq_ERYTHROID_Human0.89642849
133* SMC1_22415368_ChIP-Seq_MEFs_Mouse0.89500928
134SRY_22984422_ChIP-ChIP_TESTIS_Rat0.89090844
135NANOG_18555785_ChIP-Seq_MESCs_Mouse0.88772912
136* STAT3_18555785_ChIP-Seq_MESCs_Mouse0.87704654
137P300_27058665_Chip-Seq_ZR-75-30cells_Human0.87472875
138ZNF263_19887448_ChIP-Seq_K562_Human0.87270856
139KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.87034764
140YY1_22570637_ChIP-Seq_MALME-3M_Human0.86199528
141RACK7_27058665_Chip-Seq_MCF-7_Human0.85007476
142SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.83561130
143ELK3_25401928_ChIP-Seq_HUVEC_Human0.83335776
144JARID2_20075857_ChIP-Seq_MESCs_Mouse0.82534466
145REST_18959480_ChIP-ChIP_MESCs_Mouse0.80601046
146POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.80072526
147* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.78759078
148YY1_21170310_ChIP-Seq_MESCs_Mouse0.77216414
149ELK4_26923725_Chip-Seq_MESODERM_Mouse0.76442093
150RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.75622302
151RNF2_27304074_Chip-Seq_ESCs_Mouse0.75565794
152SOX3_22085726_ChIP-Seq_NPCs_Mouse0.72564280
153E2F4_17652178_ChIP-ChIP_JURKAT_Human0.71641691
154NCOR1_26117541_ChIP-Seq_K562_Human0.70599344
155CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.70208605
156SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.69782192
157EOMES_21245162_ChIP-Seq_HESCs_Human0.68420703
158REST_21632747_ChIP-Seq_MESCs_Mouse0.68021301
159STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.67050030
160NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.66540671

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation4.36222716
2MP0002254_reproductive_system_inflammat3.74225177
3MP0003122_maternal_imprinting3.60078780
4MP0005499_abnormal_olfactory_system3.55797918
5MP0005394_taste/olfaction_phenotype3.55797918
6MP0006292_abnormal_olfactory_placode3.47564043
7MP0000751_myopathy3.36799096
8MP0004264_abnormal_extraembryonic_tissu3.30726818
9MP0003890_abnormal_embryonic-extraembry3.08287210
10MP0008438_abnormal_cutaneous_collagen3.00281070
11MP0002735_abnormal_chemical_nociception2.88595850
12* MP0004858_abnormal_nervous_system2.86798806
13MP0002751_abnormal_autonomic_nervous2.69516399
14MP0004270_analgesia2.58014634
15MP0001348_abnormal_lacrimal_gland2.56020520
16MP0002332_abnormal_exercise_endurance2.53520771
17MP0005075_abnormal_melanosome_morpholog2.50864208
18MP0005257_abnormal_intraocular_pressure2.36239822
19MP0002653_abnormal_ependyma_morphology2.32560659
20MP0002822_catalepsy2.28117113
21MP0006276_abnormal_autonomic_nervous2.27959948
22MP0001299_abnormal_eye_distance/2.25934974
23MP0000733_abnormal_muscle_development2.22633984
24MP0003705_abnormal_hypodermis_morpholog2.20398752
25MP0002733_abnormal_thermal_nociception2.19784148
26MP0003121_genomic_imprinting2.17975383
27MP0003385_abnormal_body_wall2.07062099
28MP0010030_abnormal_orbit_morphology2.04095090
29MP0000566_synostosis2.03865221
30MP0005503_abnormal_tendon_morphology1.99604127
31* MP0002108_abnormal_muscle_morphology1.99012261
32MP0006035_abnormal_mitochondrial_morpho1.96029618
33MP0003183_abnormal_peptide_metabolism1.87820516
34MP0003938_abnormal_ear_development1.87214994
35MP0000750_abnormal_muscle_regeneration1.82559485
36MP0002734_abnormal_mechanical_nocicepti1.81440521
37MP0005275_abnormal_skin_tensile1.80403361
38MP0009379_abnormal_foot_pigmentation1.79992895
39MP0001849_ear_inflammation1.79931915
40MP0002127_abnormal_cardiovascular_syste1.76226515
41MP0010352_gastrointestinal_tract_polyps1.75167538
42MP0005423_abnormal_somatic_nervous1.70663005
43MP0000537_abnormal_urethra_morphology1.68813030
44MP0001346_abnormal_lacrimal_gland1.65343277
45MP0002932_abnormal_joint_morphology1.63291591
46MP0000678_abnormal_parathyroid_gland1.61941255
47MP0003283_abnormal_digestive_organ1.61703245
48MP0008789_abnormal_olfactory_epithelium1.60198102
49MP0001970_abnormal_pain_threshold1.58541274
50MP0009053_abnormal_anal_canal1.57779401
51MP0001968_abnormal_touch/_nociception1.56603963
52MP0001270_distended_abdomen1.50098461
53MP0008057_abnormal_DNA_replication1.47282960
54MP0004087_abnormal_muscle_fiber1.47056297
55MP0000534_abnormal_ureter_morphology1.46297971
56MP0000049_abnormal_middle_ear1.46058110
57MP0003315_abnormal_perineum_morphology1.45955173
58MP0003123_paternal_imprinting1.44804904
59MP0008961_abnormal_basal_metabolism1.44191954
60MP0003279_aneurysm1.40638885
61MP0000579_abnormal_nail_morphology1.40520510
62MP0003566_abnormal_cell_adhesion1.36129795
63MP0003942_abnormal_urinary_system1.35948454
64MP0002277_abnormal_respiratory_mucosa1.34992459
65MP0002233_abnormal_nose_morphology1.34654611
66MP0004957_abnormal_blastocyst_morpholog1.34530642
67MP0002234_abnormal_pharynx_morphology1.34446274
68MP0002089_abnormal_postnatal_growth/wei1.34429828
69MP0002697_abnormal_eye_size1.34360568
70* MP0002184_abnormal_innervation1.31306565
71* MP0000955_abnormal_spinal_cord1.28541529
72MP0004084_abnormal_cardiac_muscle1.28261702
73MP0005380_embryogenesis_phenotype1.27092444
74MP0001672_abnormal_embryogenesis/_devel1.27092444
75MP0005409_darkened_coat_color1.25993273
76MP0000372_irregular_coat_pigmentation1.25003749
77MP0000428_abnormal_craniofacial_morphol1.24190807
78MP0002114_abnormal_axial_skeleton1.23421010
79MP0005171_absent_coat_pigmentation1.20841093
80MP0003115_abnormal_respiratory_system1.19111395
81MP0005248_abnormal_Harderian_gland1.18435169
82MP0002088_abnormal_embryonic_growth/wei1.17977384
83MP0002938_white_spotting1.17330406
84MP0000767_abnormal_smooth_muscle1.16457373
85MP0005623_abnormal_meninges_morphology1.14936341
86MP0003984_embryonic_growth_retardation1.14327770
87MP0001293_anophthalmia1.13004255
88MP0003755_abnormal_palate_morphology1.12716241
89MP0003950_abnormal_plasma_membrane1.12626493
90MP0010368_abnormal_lymphatic_system1.12120773
91* MP0005369_muscle_phenotype1.10887477
92MP0002736_abnormal_nociception_after1.09606619
93MP0000747_muscle_weakness1.09150425
94MP0003137_abnormal_impulse_conducting1.07084136
95* MP0002752_abnormal_somatic_nervous1.06843534
96MP0003935_abnormal_craniofacial_develop1.06548697
97MP0002085_abnormal_embryonic_tissue1.03545973
98MP0002282_abnormal_trachea_morphology1.02611419
99MP0002106_abnormal_muscle_physiology1.02350169
100MP0001542_abnormal_bone_strength1.02089297
101MP0000749_muscle_degeneration1.01053684
102MP0008770_decreased_survivor_rate1.00638176
103MP0000462_abnormal_digestive_system0.97787902
104MP0010630_abnormal_cardiac_muscle0.96767421
105MP0001984_abnormal_olfaction0.96476502
106MP0005508_abnormal_skeleton_morphology0.96273917
107MP0002896_abnormal_bone_mineralization0.96265276
108MP0002269_muscular_atrophy0.95376756
109MP0002092_abnormal_eye_morphology0.92749230
110MP0004272_abnormal_basement_membrane0.92387769
111MP0000350_abnormal_cell_proliferation0.90520221
112MP0002084_abnormal_developmental_patter0.89801914
113* MP0000762_abnormal_tongue_morphology0.89553515
114MP0005197_abnormal_uvea_morphology0.89016162
115MP0002116_abnormal_craniofacial_bone0.85462986
116MP0001286_abnormal_eye_development0.83584874
117MP0005266_abnormal_metabolism0.82652077
118MP0002086_abnormal_extraembryonic_tissu0.82114341
119MP0000467_abnormal_esophagus_morphology0.81953202
120MP0002249_abnormal_larynx_morphology0.81392705
121MP0002970_abnormal_white_adipose0.81092314
122MP0000163_abnormal_cartilage_morphology0.78744436
123MP0001986_abnormal_taste_sensitivity0.78705844
124MP0001958_emphysema0.78606048
125MP0001905_abnormal_dopamine_level0.78380413
126MP0008932_abnormal_embryonic_tissue0.78138252
127MP0000778_abnormal_nervous_system0.77919741
128MP0003787_abnormal_imprinting0.77876715
129MP0002111_abnormal_tail_morphology0.77201606
130MP0002909_abnormal_adrenal_gland0.76983771
131MP0009278_abnormal_bone_marrow0.76468437
132MP0002295_abnormal_pulmonary_circulatio0.76351134
133MP0004133_heterotaxia0.75725978
134* MP0001943_abnormal_respiration0.75616556
135* MP0003861_abnormal_nervous_system0.75534892
136MP0003119_abnormal_digestive_system0.75442625
137* MP0002081_perinatal_lethality0.74675584
138MP0001879_abnormal_lymphatic_vessel0.73094882
139* MP0000432_abnormal_head_morphology0.71830383
140MP0009250_abnormal_appendicular_skeleto0.71535534
141MP0000003_abnormal_adipose_tissue0.70909530
142MP0005377_hearing/vestibular/ear_phenot0.68820493
143MP0003878_abnormal_ear_physiology0.68820493
144MP0003045_fibrosis0.68515570
145* MP0002882_abnormal_neuron_morphology0.68400552
146MP0004085_abnormal_heartbeat0.66661294
147MP0008872_abnormal_physiological_respon0.65802507
148MP0003937_abnormal_limbs/digits/tail_de0.65030507
149* MP0000759_abnormal_skeletal_muscle0.62321309
150MP0009703_decreased_birth_body0.61202887
151MP0002272_abnormal_nervous_system0.60660747
152MP0004197_abnormal_fetal_growth/weight/0.60540254
153* MP0002925_abnormal_cardiovascular_devel0.59334140

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)6.97000200
2Popliteal pterygium (HP:0009756)6.80618121
3Hepatoblastoma (HP:0002884)5.42389335
4Hypochromic microcytic anemia (HP:0004840)5.28291190
5Abnormality of the lower motor neuron (HP:0002366)5.21450364
6Fetal akinesia sequence (HP:0001989)5.18105500
7Amniotic constriction ring (HP:0009775)5.03254111
8Abnormality of placental membranes (HP:0011409)5.03254111
9Pterygium (HP:0001059)4.76243185
10Type 2 muscle fiber atrophy (HP:0003554)4.65683005
11Aplasia of the musculature (HP:0100854)4.57559914
12Abnormality of the neuromuscular junction (HP:0003398)4.52519627
13Fatigable weakness (HP:0003473)4.52519627
14Ulnar claw (HP:0001178)4.49998979
15Muscle fiber atrophy (HP:0100295)4.39101768
16Thin ribs (HP:0000883)4.36830828
17Rib fusion (HP:0000902)4.11567601
18Malignant hyperthermia (HP:0002047)4.04571010
19Multiple enchondromatosis (HP:0005701)3.96546332
20Ependymoma (HP:0002888)3.60821283
21Weak cry (HP:0001612)3.34917194
22Akinesia (HP:0002304)3.30758593
23Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.30122107
24Rectovaginal fistula (HP:0000143)3.29432277
25Rectal fistula (HP:0100590)3.29432277
26Neoplasm of striated muscle (HP:0009728)3.24138604
27Gowers sign (HP:0003391)3.15573243
28Nephroblastoma (Wilms tumor) (HP:0002667)3.10996807
29Round ear (HP:0100830)3.08156459
30Easy fatigability (HP:0003388)3.07299607
31Bifid tongue (HP:0010297)3.04002813
32Calcaneovalgus deformity (HP:0001848)3.03444140
33Aplasia/Hypoplasia of the fovea (HP:0008060)2.95531258
34Hypoplasia of the fovea (HP:0007750)2.95531258
35Intestinal fistula (HP:0100819)2.94365582
36Renal duplication (HP:0000075)2.91650444
37Embryonal renal neoplasm (HP:0011794)2.90216657
38Rhabdomyosarcoma (HP:0002859)2.89589883
39Protrusio acetabuli (HP:0003179)2.89499705
40Astrocytoma (HP:0009592)2.87525713
41Abnormality of the astrocytes (HP:0100707)2.87525713
42Vaginal fistula (HP:0004320)2.79662864
43Abnormality of the musculature of the hand (HP:0001421)2.78680317
44Deformed tarsal bones (HP:0008119)2.73837089
45Generalized hypotonia (HP:0001290)2.71269852
46Shallow orbits (HP:0000586)2.70978177
47Short humerus (HP:0005792)2.70203999
48Decreased number of peripheral myelinated nerve fibers (HP:0003380)2.70079682
49Amyotrophic lateral sclerosis (HP:0007354)2.70019665
50Upper limb muscle weakness (HP:0003484)2.69732703
51Testicular atrophy (HP:0000029)2.68190646
52Amblyopia (HP:0000646)2.65935644
53Febrile seizures (HP:0002373)2.65466805
54Aplasia/hypoplasia of the humerus (HP:0006507)2.64099013
55Neoplasm of the heart (HP:0100544)2.63480987
56Premature rupture of membranes (HP:0001788)2.62137727
57Difficulty running (HP:0009046)2.61230763
58Horizontal nystagmus (HP:0000666)2.58883841
59Vertebral clefting (HP:0008428)2.57886527
60Fused cervical vertebrae (HP:0002949)2.57678465
61Cerebral aneurysm (HP:0004944)2.55930154
62Ragged-red muscle fibers (HP:0003200)2.55834601
63Steppage gait (HP:0003376)2.54457000
64Distal arthrogryposis (HP:0005684)2.52368727
65Nonprogressive disorder (HP:0003680)2.51180504
66Abnormality of pain sensation (HP:0010832)2.50944664
67Impaired pain sensation (HP:0007328)2.50944664
68Abnormality of the salivary glands (HP:0010286)2.48466449
69Anomalous pulmonary venous return (HP:0010772)2.48418344
70Hand muscle atrophy (HP:0009130)2.46144495
71Limb-girdle muscle atrophy (HP:0003797)2.44736418
72Increased variability in muscle fiber diameter (HP:0003557)2.44525117
73Increased connective tissue (HP:0009025)2.43491550
74Malignant neoplasm of the central nervous system (HP:0100836)2.40297581
75Abnormality of the corticospinal tract (HP:0002492)2.37787170
76Impaired proprioception (HP:0010831)2.37287638
77Preauricular pit (HP:0004467)2.36771839
78Periauricular skin pits (HP:0100277)2.36771839
79Nasolacrimal duct obstruction (HP:0000579)2.36119527
80Aplasia/Hypoplasia involving the musculature (HP:0001460)2.34674959
81Segmental peripheral demyelination/remyelination (HP:0003481)2.33627311
82Bulbar palsy (HP:0001283)2.32514329
83Orthostatic hypotension (HP:0001278)2.31301818
84Action tremor (HP:0002345)2.30107936
85Partial duplication of thumb phalanx (HP:0009944)2.29984118
86Abnormality of the calcaneus (HP:0008364)2.29218079
87Turricephaly (HP:0000262)2.27622168
88Depressed nasal tip (HP:0000437)2.27560116
89Large earlobe (HP:0009748)2.27525085
90Sensory axonal neuropathy (HP:0003390)2.27516161
91Shawl scrotum (HP:0000049)2.26178931
92Preauricular skin tag (HP:0000384)2.24442971
93Rocker bottom foot (HP:0001838)2.23486141
94Abnormal lung lobation (HP:0002101)2.21256911
95Ulnar deviation of the wrist (HP:0003049)2.21049104
96Aplasia/Hypoplasia of the macula (HP:0008059)2.19248311
97Dysautonomia (HP:0002459)2.18858130
98Supernumerary nipples (HP:0002558)2.18721538
99Abnormality of the phalanges of the hallux (HP:0010057)2.18668066
100Hyperinsulinemic hypoglycemia (HP:0000825)2.17863620
101Abnormality of the fovea (HP:0000493)2.17791700
102Chromosomal breakage induced by crosslinking agents (HP:0003221)2.17519008
103Abnormalities of placenta or umbilical cord (HP:0001194)2.17290534
104Fasciculations (HP:0002380)2.16075289
105Distal lower limb muscle weakness (HP:0009053)2.14427465
106Cystic hygroma (HP:0000476)2.14289874
107Type 1 muscle fiber predominance (HP:0003803)2.14132873
108Abnormality of the pubic bones (HP:0003172)2.13909881
109Abnormal cartilage morphology (HP:0002763)2.12346527
110Abnormality of the pulmonary veins (HP:0011718)2.11998697
111Hypoplastic heart (HP:0001961)2.10817012
112Partial duplication of the phalanx of hand (HP:0009999)2.10692162
113Failure to thrive in infancy (HP:0001531)2.09782175
114Nervous tissue neoplasm (HP:0030060)2.07761417
115Neuroectodermal neoplasm (HP:0030061)2.07761417
116Neuroepithelial neoplasm (HP:0030063)2.07761417
117Short 5th finger (HP:0009237)2.07365594
118Neuroblastoma (HP:0003006)2.04408252
119Primitive neuroectodermal tumor (HP:0030065)2.04408252
120Neuroblastic tumors (HP:0004376)2.04408252
121Peripheral primitive neuroectodermal neoplasm (HP:0030067)2.04408252
122Glioma (HP:0009733)2.04219622
123Muscle fibrillation (HP:0010546)2.03999443
124Skin tags (HP:0010609)2.03185016
125Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.02816367
126Absent epiphyses (HP:0010577)2.02816367
127Trismus (HP:0000211)2.01416392
128Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.01289089
129Hyperacusis (HP:0010780)2.01028450
130Broad metatarsal (HP:0001783)2.00787954
131Tetraplegia (HP:0002445)2.00730212
132Tongue fasciculations (HP:0001308)2.00567634
133Atrophic scars (HP:0001075)1.99057885
134Abnormality of the calf musculature (HP:0001430)1.98947855
135EMG: neuropathic changes (HP:0003445)1.98407360
136Aplasia/Hypoplasia affecting the retina (HP:0008061)1.98317005
137Hip contracture (HP:0003273)1.98277545
138Respiratory insufficiency due to muscle weakness (HP:0002747)1.97904291
139Abnormality of the distal phalanx of the thumb (HP:0009617)1.97885104
140Abnormality of skeletal muscle fiber size (HP:0012084)1.96330060
141Distal upper limb amyotrophy (HP:0007149)1.94833047
142Upper limb amyotrophy (HP:0009129)1.94833047
143Myopathic facies (HP:0002058)1.92837427
144Thyroid carcinoma (HP:0002890)1.92087678
145Impulsivity (HP:0100710)1.90917551
146Hyperventilation (HP:0002883)1.90569830
147Arthropathy (HP:0003040)1.90436023
148Abnormality of the parietal bone (HP:0002696)1.88012256
149Abnormality of the lacrimal duct (HP:0011481)1.86831421
150Sudden death (HP:0001699)1.86493398
151Limited hip movement (HP:0008800)1.86420824
152Pendular nystagmus (HP:0012043)1.86044994
153Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.85888070
154Hypoplastic ischia (HP:0003175)1.85532277
155Down-sloping shoulders (HP:0200021)1.84963397
156Bladder diverticulum (HP:0000015)1.84574935
157Mildly elevated creatine phosphokinase (HP:0008180)1.84185304
158Generalized amyotrophy (HP:0003700)1.83693038
159Trigonocephaly (HP:0000243)1.83089540
160Aortic dissection (HP:0002647)1.82755333
161Nemaline bodies (HP:0003798)1.82354461
162Coronal craniosynostosis (HP:0004440)1.82333047
163Obstructive sleep apnea (HP:0002870)1.81733869
164Scapular winging (HP:0003691)1.80656888
165Vitreoretinal degeneration (HP:0000655)1.79823002
166Muscle fiber splitting (HP:0003555)1.78507747
167Arterial tortuosity (HP:0005116)1.78294579
168Arthrogryposis multiplex congenita (HP:0002804)1.78291094
169Short thorax (HP:0010306)1.75367936
170Calf muscle hypertrophy (HP:0008981)1.74085118
171Overriding aorta (HP:0002623)1.73400364
172Spinal rigidity (HP:0003306)1.72033199
173Insomnia (HP:0100785)1.70333340
174Vertebral fusion (HP:0002948)1.69824490
175Epiphyseal dysplasia (HP:0002656)1.69376992
176Hypoplasia of the iris (HP:0007676)1.68910239
177Absent septum pellucidum (HP:0001331)1.68697596
178Short palpebral fissure (HP:0012745)1.68300870
179Neurofibrillary tangles (HP:0002185)1.66420631
180Aortic aneurysm (HP:0004942)1.66125391
181Fragile skin (HP:0001030)1.64668234
182Neonatal short-limb short stature (HP:0008921)1.64469462
183Abnormality of the ischium (HP:0003174)1.63991239
184Bell-shaped thorax (HP:0001591)1.63662342
185Midline defect of the nose (HP:0004122)1.63252199
186Abnormality of dentin (HP:0010299)1.60157334
187Abnormality of the aortic arch (HP:0012303)1.59242001
188Abnormality of the diencephalon (HP:0010662)1.58691126
189Adducted thumb (HP:0001181)1.57442756

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK127.24146616
2MUSK5.66345965
3GRK55.31791125
4NTRK14.13566042
5ERN13.76606547
6MATK3.73518363
7EPHB23.64361792
8GRK63.42857587
9ADRBK22.94821171
10GRK72.67880579
11WNK12.61872125
12GRK12.49431689
13TYRO32.34237610
14CSF1R2.28471895
15EPHA42.28359224
16TGFBR22.11784869
17TRIB32.04967443
18LATS22.03418261
19VRK22.01761647
20NTRK31.85020374
21MAPK71.76976943
22MAP2K41.72536425
23MOS1.69375377
24TTK1.68771887
25MAP3K91.62153167
26LMTK21.61508333
27PRKG21.56969039
28ADRBK11.47092742
29EEF2K1.44965766
30CAMK41.35153977
31STK101.33093349
32TESK11.32890783
33ILK1.29985735
34MARK21.29654145
35FGFR41.28589630
36SMG11.27918101
37MINK11.23926380
38NTRK21.21601444
39FGFR21.18898827
40DYRK1B1.18162271
41NME21.15262026
42FGFR31.13049208
43ROCK21.10967619
44MAPKAPK31.10637639
45BRD41.09529710
46HIPK21.07060927
47CDK81.06095594
48LATS11.04502957
49CDK71.01511641
50AKT30.99792686
51MAP3K60.99231369
52DAPK30.94214889
53EPHB10.93312419
54ERBB20.92783461
55STK160.92512602
56MYLK0.87586993
57DMPK0.87564574
58TAF10.85992437
59TTN0.85391388
60KSR20.85265472
61MET0.83871362
62PBK0.83684083
63PRKD30.81330202
64PTK60.81248508
65PAK40.79089589
66PHKG20.76426661
67PHKG10.76426661
68PTK20.75925307
69PAK60.74673790
70MAP2K60.74126054
71CHEK20.73837787
72NEK10.73751984
73TGFBR10.69334054
74ALK0.67242736
75EPHA30.65802735
76MAPK150.64161318
77PIK3CG0.64148488
78DYRK20.59671655
79EPHA20.59128671
80ARAF0.58841483
81MAP3K70.58167623
82PAK20.57869357
83MTOR0.56833150
84LIMK10.56405004
85STK38L0.56077447
86PDGFRA0.55858356
87PLK10.55808487
88CDK90.54387971
89CASK0.54006844
90MAP3K100.53749853
91ERBB40.53399353
92RET0.52047908
93DDR20.51528378
94PKN20.51191807
95IGF1R0.49759470
96CSNK1E0.48969842
97AKT20.48242541
98PNCK0.48191212
99RIPK10.48114405
100MAPK120.46771223
101RPS6KB20.46241756
102ICK0.45147338
103PDGFRB0.45016581
104STK380.44625235
105PASK0.44317561
106CAMK2D0.43404683
107MAP3K40.43356828
108ROCK10.42832270
109MAPK100.42328185
110NME10.41704000
111PKN10.40952771
112CDK140.40462917
113UHMK10.39587158
114AURKA0.39522474
115CHEK10.38149683
116CDK150.36868880
117FGFR10.35975799
118CDK180.35844153
119PRKD10.35211670
120CDK190.35204616
121CSK0.34955642
122PRKCI0.34914123
123CSNK1G20.34901907
124CAMK2G0.34381417
125PAK30.33877439
126MAPK90.31635159
127CSNK1A1L0.31332121
128MARK10.30784381
129INSR0.30559623
130CDK11A0.30468314
131CDC42BPA0.28628526
132LRRK20.27688157
133FLT30.27577616
134KDR0.26928679
135CDK20.26821766
136GSK3B0.25273501
137PRKCD0.25240134
138PRKAA10.25038040
139ABL20.24939680
140MAP2K10.24566898
141DYRK1A0.24280034
142FER0.24237253
143EIF2AK20.24173273
144SCYL20.23649208
145PAK10.22408872
146RPS6KA20.21563670
147CDK50.21450543
148BMX0.21109727
149PRKACA0.20953215
150MAPK10.20708489
151MAPK80.19765860
152SRC0.19512441
153MAP3K20.18984955
154GSK3A0.18591559
155TAOK10.18103975
156SIK10.17524977
157RPS6KA30.17516458
158MAPK40.15670464
159CDK10.14821949
160MAPK140.13592564

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006035.71054215
2Vitamin B6 metabolism_Homo sapiens_hsa007505.13355439
3Fructose and mannose metabolism_Homo sapiens_hsa000513.45134983
4Cyanoamino acid metabolism_Homo sapiens_hsa004603.21674738
5ECM-receptor interaction_Homo sapiens_hsa045122.92386931
6Thyroid cancer_Homo sapiens_hsa052162.85515190
7Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.64937888
8Ribosome_Homo sapiens_hsa030102.53183275
9Notch signaling pathway_Homo sapiens_hsa043302.23943684
10Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.22018323
11Galactose metabolism_Homo sapiens_hsa000522.14932959
12Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050142.14001082
13Cardiac muscle contraction_Homo sapiens_hsa042602.11501674
14mTOR signaling pathway_Homo sapiens_hsa041501.99464798
15Focal adhesion_Homo sapiens_hsa045101.94701783
16Central carbon metabolism in cancer_Homo sapiens_hsa052301.91620720
17Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.90187604
18Prion diseases_Homo sapiens_hsa050201.86955392
19Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.86223878
20Arachidonic acid metabolism_Homo sapiens_hsa005901.68495030
21Hedgehog signaling pathway_Homo sapiens_hsa043401.64174402
22Linoleic acid metabolism_Homo sapiens_hsa005911.52916070
23alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.48320768
24Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.48119804
25Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.47418777
26Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.44483839
27Phospholipase D signaling pathway_Homo sapiens_hsa040721.42150857
28Taste transduction_Homo sapiens_hsa047421.39810482
29Synaptic vesicle cycle_Homo sapiens_hsa047211.34182350
30Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.29566041
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.28794323
32Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.17332950
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.16721998
34Basal cell carcinoma_Homo sapiens_hsa052171.15621119
35Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.14446136
36Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.09189627
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.07627402
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.06398216
39Choline metabolism in cancer_Homo sapiens_hsa052311.06076159
40Hippo signaling pathway_Homo sapiens_hsa043901.02945061
41Inositol phosphate metabolism_Homo sapiens_hsa005621.00706257
42GnRH signaling pathway_Homo sapiens_hsa049120.99146085
43VEGF signaling pathway_Homo sapiens_hsa043700.97790072
44Small cell lung cancer_Homo sapiens_hsa052220.97700301
45Phosphatidylinositol signaling system_Homo sapiens_hsa040700.97657894
46Dorso-ventral axis formation_Homo sapiens_hsa043200.97098252
47Regulation of actin cytoskeleton_Homo sapiens_hsa048100.95010696
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.93642355
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.92760714
50Ovarian steroidogenesis_Homo sapiens_hsa049130.91869722
51Axon guidance_Homo sapiens_hsa043600.91635322
52Parkinsons disease_Homo sapiens_hsa050120.90774111
53Phenylalanine metabolism_Homo sapiens_hsa003600.89859583
54Serotonergic synapse_Homo sapiens_hsa047260.89833838
55Amoebiasis_Homo sapiens_hsa051460.89721402
56Pathways in cancer_Homo sapiens_hsa052000.88899265
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86790900
58Histidine metabolism_Homo sapiens_hsa003400.85247226
59Folate biosynthesis_Homo sapiens_hsa007900.84081809
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.83603143
61Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82869981
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.82576393
63Endometrial cancer_Homo sapiens_hsa052130.80483529
64Long-term depression_Homo sapiens_hsa047300.79587443
65Wnt signaling pathway_Homo sapiens_hsa043100.78654777
66TGF-beta signaling pathway_Homo sapiens_hsa043500.78076500
67Huntingtons disease_Homo sapiens_hsa050160.77760843
68Lysine degradation_Homo sapiens_hsa003100.77273794
69Biosynthesis of amino acids_Homo sapiens_hsa012300.77211189
70Chronic myeloid leukemia_Homo sapiens_hsa052200.75990456
71Non-small cell lung cancer_Homo sapiens_hsa052230.75046514
72Cocaine addiction_Homo sapiens_hsa050300.74438448
73Oxidative phosphorylation_Homo sapiens_hsa001900.73221367
74Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72918672
75* Rap1 signaling pathway_Homo sapiens_hsa040150.72520836
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.72150246
77Colorectal cancer_Homo sapiens_hsa052100.72009531
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.71919806
79ErbB signaling pathway_Homo sapiens_hsa040120.71891977
80Gap junction_Homo sapiens_hsa045400.71401197
81Vascular smooth muscle contraction_Homo sapiens_hsa042700.71401185
82Sulfur relay system_Homo sapiens_hsa041220.70159972
83Alzheimers disease_Homo sapiens_hsa050100.69900240
84Dopaminergic synapse_Homo sapiens_hsa047280.68159768
85Glioma_Homo sapiens_hsa052140.68023865
86AMPK signaling pathway_Homo sapiens_hsa041520.67625839
87Tyrosine metabolism_Homo sapiens_hsa003500.67566105
88Arginine and proline metabolism_Homo sapiens_hsa003300.65587715
89Melanoma_Homo sapiens_hsa052180.65573790
90Bladder cancer_Homo sapiens_hsa052190.65352736
91Vibrio cholerae infection_Homo sapiens_hsa051100.64808806
92Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.64396478
93Ether lipid metabolism_Homo sapiens_hsa005650.64247722
94* Neurotrophin signaling pathway_Homo sapiens_hsa047220.64046704
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.62643440
96Regulation of autophagy_Homo sapiens_hsa041400.62622138
97Proteoglycans in cancer_Homo sapiens_hsa052050.61656586
98Glutamatergic synapse_Homo sapiens_hsa047240.61561604
99Oocyte meiosis_Homo sapiens_hsa041140.60652164
100Protein digestion and absorption_Homo sapiens_hsa049740.58677516
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.57484765
102Acute myeloid leukemia_Homo sapiens_hsa052210.56847115
103GABAergic synapse_Homo sapiens_hsa047270.56333186
104Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.56333024
105MicroRNAs in cancer_Homo sapiens_hsa052060.55652824
106Calcium signaling pathway_Homo sapiens_hsa040200.55574148
107mRNA surveillance pathway_Homo sapiens_hsa030150.55027169
108Chemical carcinogenesis_Homo sapiens_hsa052040.54460763
109Complement and coagulation cascades_Homo sapiens_hsa046100.53830103
110Circadian entrainment_Homo sapiens_hsa047130.53170305
111cGMP-PKG signaling pathway_Homo sapiens_hsa040220.52385369
112Dilated cardiomyopathy_Homo sapiens_hsa054140.52174899
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51136002
114Long-term potentiation_Homo sapiens_hsa047200.51089600
115Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.50250945
116Oxytocin signaling pathway_Homo sapiens_hsa049210.50196521
117Glucagon signaling pathway_Homo sapiens_hsa049220.50152107
118Pancreatic cancer_Homo sapiens_hsa052120.49288197
119Arginine biosynthesis_Homo sapiens_hsa002200.48945690
120Cholinergic synapse_Homo sapiens_hsa047250.48498135
121MAPK signaling pathway_Homo sapiens_hsa040100.47828807
122Tight junction_Homo sapiens_hsa045300.47718201
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.47518020
124Insulin signaling pathway_Homo sapiens_hsa049100.47068781
125Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46847093
126Olfactory transduction_Homo sapiens_hsa047400.46626710
127Cell cycle_Homo sapiens_hsa041100.46321780
128Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46318011
129Circadian rhythm_Homo sapiens_hsa047100.45931271
130Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.45929478
131Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45316263
132AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45298982
133RNA transport_Homo sapiens_hsa030130.45070365
134cAMP signaling pathway_Homo sapiens_hsa040240.44944816
135Renal cell carcinoma_Homo sapiens_hsa052110.44630382
136Spliceosome_Homo sapiens_hsa030400.44568842
137Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44412928
138Salivary secretion_Homo sapiens_hsa049700.44247034
139Adherens junction_Homo sapiens_hsa045200.43958346
140Bile secretion_Homo sapiens_hsa049760.43101991
141Renin secretion_Homo sapiens_hsa049240.42158630
142Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.41632379
143* PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41107886
144African trypanosomiasis_Homo sapiens_hsa051430.40712654
145Prostate cancer_Homo sapiens_hsa052150.40703051
146Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40650926
147Melanogenesis_Homo sapiens_hsa049160.40564267
148p53 signaling pathway_Homo sapiens_hsa041150.39617603
149Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.38732273
150Glycosaminoglycan degradation_Homo sapiens_hsa005310.38654027
151Endocytosis_Homo sapiens_hsa041440.38254983
152Estrogen signaling pathway_Homo sapiens_hsa049150.37755231
153* Ras signaling pathway_Homo sapiens_hsa040140.36372478

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