NGLY1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that catalyzes hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl) asparagine residue to N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue. The encoded enzyme may play a role in the proteasome-mediated degradation of misfolded glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synapsis (GO:0007129)5.07213192
2L-phenylalanine catabolic process (GO:0006559)4.81861306
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.81861306
4fusion of sperm to egg plasma membrane (GO:0007342)4.77022362
5fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.57167694
6piRNA metabolic process (GO:0034587)4.55180270
7aromatic amino acid family catabolic process (GO:0009074)4.50123119
8L-phenylalanine metabolic process (GO:0006558)4.49018536
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.49018536
10cell wall macromolecule metabolic process (GO:0044036)4.38174462
11cell wall macromolecule catabolic process (GO:0016998)4.38174462
12sperm motility (GO:0030317)4.27383805
13indole-containing compound catabolic process (GO:0042436)4.17915092
14indolalkylamine catabolic process (GO:0046218)4.17915092
15tryptophan catabolic process (GO:0006569)4.17915092
16tryptophan metabolic process (GO:0006568)4.14538336
17alpha-linolenic acid metabolic process (GO:0036109)4.11809097
18cysteine metabolic process (GO:0006534)4.08294296
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.06731317
20antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.06731317
21valine metabolic process (GO:0006573)3.94584585
22sulfur amino acid catabolic process (GO:0000098)3.93309808
23organic cation transport (GO:0015695)3.88762496
24kynurenine metabolic process (GO:0070189)3.79167897
25triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.77445608
26male meiosis I (GO:0007141)3.77319433
27antigen processing and presentation of endogenous antigen (GO:0019883)3.65845068
28complement activation, alternative pathway (GO:0006957)3.63320061
29multicellular organism reproduction (GO:0032504)3.62913081
30lysine catabolic process (GO:0006554)3.62681750
31lysine metabolic process (GO:0006553)3.62681750
32bile acid biosynthetic process (GO:0006699)3.61117650
33amino-acid betaine metabolic process (GO:0006577)3.60609933
34urea metabolic process (GO:0019627)3.53669310
35urea cycle (GO:0000050)3.53669310
36positive regulation of B cell differentiation (GO:0045579)3.53608468
37plasma membrane fusion (GO:0045026)3.52004774
38DNA methylation involved in gamete generation (GO:0043046)3.45936673
39cellular ketone body metabolic process (GO:0046950)3.44865279
40sperm-egg recognition (GO:0035036)3.44507086
41acrosome reaction (GO:0007340)3.43186330
42drug transmembrane transport (GO:0006855)3.40515849
43regulation of triglyceride catabolic process (GO:0010896)3.39229461
44acrosome assembly (GO:0001675)3.38016515
45resolution of meiotic recombination intermediates (GO:0000712)3.35132822
46positive regulation of gamma-delta T cell activation (GO:0046645)3.28825622
47fatty acid beta-oxidation (GO:0006635)3.28309198
48glyoxylate metabolic process (GO:0046487)3.27658918
49male meiosis (GO:0007140)3.27283853
50reproduction (GO:0000003)3.26057042
51carnitine transport (GO:0015879)3.24563800
52amino-acid betaine transport (GO:0015838)3.24563800
53DNA deamination (GO:0045006)3.24535503
54reciprocal DNA recombination (GO:0035825)3.22566008
55reciprocal meiotic recombination (GO:0007131)3.22566008
56nitrogen cycle metabolic process (GO:0071941)3.22558766
57positive regulation of granulocyte differentiation (GO:0030854)3.20785848
58cell-cell recognition (GO:0009988)3.20705549
59DNA double-strand break processing (GO:0000729)3.19982743
60fatty acid catabolic process (GO:0009062)3.19609509
61RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.19251407
62positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.19022069
63chromosome organization involved in meiosis (GO:0070192)3.18644452
64aromatic amino acid family metabolic process (GO:0009072)3.18326620
65carnitine transmembrane transport (GO:1902603)3.16360607
66fucose catabolic process (GO:0019317)3.15882008
67L-fucose metabolic process (GO:0042354)3.15882008
68L-fucose catabolic process (GO:0042355)3.15882008
69proteasome assembly (GO:0043248)3.15655985
70indolalkylamine metabolic process (GO:0006586)3.14841226
71regulation of protein activation cascade (GO:2000257)3.13348837
72bile acid metabolic process (GO:0008206)3.11978760
73carnitine metabolic process (GO:0009437)3.11721248
74meiosis I (GO:0007127)3.10634461
75tyrosine metabolic process (GO:0006570)3.10364371
76ubiquinone biosynthetic process (GO:0006744)3.08933725
77ethanol oxidation (GO:0006069)3.08700786
78centriole replication (GO:0007099)3.07164036
79fatty acid oxidation (GO:0019395)3.07063765
80high-density lipoprotein particle remodeling (GO:0034375)3.06236350
81short-chain fatty acid metabolic process (GO:0046459)3.06154127
82lipid oxidation (GO:0034440)3.04581931
83peptidyl-glutamic acid carboxylation (GO:0017187)3.03494961
84protein carboxylation (GO:0018214)3.03494961
85adenosine metabolic process (GO:0046085)3.02355766
86binding of sperm to zona pellucida (GO:0007339)3.02314327
87regulation of meiosis I (GO:0060631)3.00583897
88drug transport (GO:0015893)3.00375288
89regulation of complement activation (GO:0030449)2.96238593
90monocarboxylic acid catabolic process (GO:0072329)2.95486853
91homocysteine metabolic process (GO:0050667)2.94749766
92neural tube formation (GO:0001841)2.92005722
93positive regulation of histone H3-K4 methylation (GO:0051571)2.91731263
94ketone body metabolic process (GO:1902224)2.91270187
95DNA catabolic process, exonucleolytic (GO:0000738)2.91158198
96double-strand break repair via homologous recombination (GO:0000724)2.89341676
97branched-chain amino acid metabolic process (GO:0009081)2.88361716
98quaternary ammonium group transport (GO:0015697)2.87717773
99meiotic chromosome segregation (GO:0045132)2.87566677
100recombinational repair (GO:0000725)2.86678938
101coenzyme catabolic process (GO:0009109)2.86219413
102regulation of cholesterol esterification (GO:0010872)2.86197272
1032-oxoglutarate metabolic process (GO:0006103)2.85358550
104acylglycerol homeostasis (GO:0055090)2.84175760
105triglyceride homeostasis (GO:0070328)2.84175760
106reverse cholesterol transport (GO:0043691)2.80957665
107phospholipid efflux (GO:0033700)2.80155100
108plasma lipoprotein particle remodeling (GO:0034369)2.79597507
109protein-lipid complex remodeling (GO:0034368)2.79597507
110macromolecular complex remodeling (GO:0034367)2.79597507
111cellular modified amino acid catabolic process (GO:0042219)2.79208042
112fatty acid transmembrane transport (GO:1902001)2.79003156
113plasma lipoprotein particle clearance (GO:0034381)2.78929788
114cilium or flagellum-dependent cell motility (GO:0001539)2.78108475
115rRNA catabolic process (GO:0016075)2.77403300
116cofactor catabolic process (GO:0051187)2.77158617
117alpha-amino acid catabolic process (GO:1901606)2.75818221
118low-density lipoprotein particle remodeling (GO:0034374)2.75566286
119regulation of cholesterol metabolic process (GO:0090181)2.73186963
120carboxylic acid catabolic process (GO:0046395)2.72908452
121organic acid catabolic process (GO:0016054)2.72908452
122aspartate family amino acid catabolic process (GO:0009068)2.71652533
123regulation of B cell receptor signaling pathway (GO:0050855)2.71315236
124response to mercury ion (GO:0046689)2.71193058
125branched-chain amino acid catabolic process (GO:0009083)2.70517711
126cellular amino acid catabolic process (GO:0009063)2.68907686
127monoubiquitinated protein deubiquitination (GO:0035520)2.68463010
128ubiquinone metabolic process (GO:0006743)2.68025748
129response to pheromone (GO:0019236)2.66957250
130acetyl-CoA metabolic process (GO:0006084)2.65857856
131benzene-containing compound metabolic process (GO:0042537)2.65625361
132regulation of sequestering of triglyceride (GO:0010889)2.65608077
133regulation of gamma-delta T cell differentiation (GO:0045586)2.65278086
134negative regulation of fibrinolysis (GO:0051918)2.65121374
135regulation of B cell differentiation (GO:0045577)2.64244292
136antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.63692067
137Peyers patch development (GO:0048541)2.61468303
138mucosal-associated lymphoid tissue development (GO:0048537)2.61468303
139B cell receptor signaling pathway (GO:0050853)2.59341717
140meiotic nuclear division (GO:0007126)2.58877467
141quinone biosynthetic process (GO:1901663)2.58815915
142positive regulation of alpha-beta T cell proliferation (GO:0046641)2.56654318
143negative regulation of thymocyte apoptotic process (GO:0070244)2.55907004
144positive regulation of defense response to virus by host (GO:0002230)2.50372319
145respiratory chain complex IV assembly (GO:0008535)2.49185870
146somatic diversification of immune receptors via somatic mutation (GO:0002566)2.48574899
147somatic hypermutation of immunoglobulin genes (GO:0016446)2.48574899
148replication fork processing (GO:0031297)2.46294104
149L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.42868923
150activated T cell proliferation (GO:0050798)2.42659311
151gene silencing by RNA (GO:0031047)2.39685863
152purinergic nucleotide receptor signaling pathway (GO:0035590)2.38643949
153histone H3-K9 methylation (GO:0051567)2.38470557
154regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.38441347
155regulation of B cell apoptotic process (GO:0002902)2.34292164
156regulation of gamma-delta T cell activation (GO:0046643)2.33442217
157pseudouridine synthesis (GO:0001522)2.33431322
158meiotic cell cycle process (GO:1903046)2.33308200
159photoreceptor cell maintenance (GO:0045494)2.32343190
160sister chromatid cohesion (GO:0007062)2.30880322
161cellular response to exogenous dsRNA (GO:0071360)2.30472020
162somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.29366195
163isotype switching (GO:0045190)2.29366195
164somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.29366195
165mast cell activation involved in immune response (GO:0002279)2.28360375
166mast cell degranulation (GO:0043303)2.28360375
167protein K6-linked ubiquitination (GO:0085020)2.28330235
168negative regulation by host of viral transcription (GO:0043922)2.27311681
169protein K63-linked deubiquitination (GO:0070536)2.25478434
170rRNA modification (GO:0000154)2.25270860
171preassembly of GPI anchor in ER membrane (GO:0016254)2.24756123
172cytochrome complex assembly (GO:0017004)2.24624976
173regulation of alpha-beta T cell proliferation (GO:0046640)2.23525821
174regulation of memory T cell differentiation (GO:0043380)2.22707426
175mannosylation (GO:0097502)2.22658441
176mismatch repair (GO:0006298)2.20819284
177regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.20290543
178response to interleukin-15 (GO:0070672)2.19960284
179mitochondrial RNA metabolic process (GO:0000959)2.19783422
180L-methionine salvage (GO:0071267)2.18118180
181L-methionine biosynthetic process (GO:0071265)2.18118180
182amino acid salvage (GO:0043102)2.18118180
183DNA synthesis involved in DNA repair (GO:0000731)2.16447940
184negative regulation of DNA-dependent DNA replication (GO:2000104)2.15909936
185regulation of interleukin-12 biosynthetic process (GO:0045075)2.14714406
186centriole assembly (GO:0098534)2.14131860
187double-strand break repair (GO:0006302)2.13969387
188platelet dense granule organization (GO:0060155)2.13472731
189methionine biosynthetic process (GO:0009086)2.13361848
190DNA recombination (GO:0006310)2.13153328

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.11857326
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.37200154
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.02198438
4EGR1_23403033_ChIP-Seq_LIVER_Mouse3.98403894
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.89758124
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.51265724
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.10409970
8ZNF274_21170338_ChIP-Seq_K562_Hela3.01540559
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.92648386
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.71896707
11VDR_22108803_ChIP-Seq_LS180_Human2.66662671
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.65495202
13CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.61142158
14E2F7_22180533_ChIP-Seq_HELA_Human2.58185369
15GABP_17652178_ChIP-ChIP_JURKAT_Human2.52055231
16KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.43852354
17EST1_17652178_ChIP-ChIP_JURKAT_Human2.42095864
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.39391094
19SALL1_21062744_ChIP-ChIP_HESCs_Human2.34206692
20IRF8_21731497_ChIP-ChIP_J774_Mouse2.30476663
21FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.27983401
22VDR_23849224_ChIP-Seq_CD4+_Human2.26534384
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.20159542
24IGF1R_20145208_ChIP-Seq_DFB_Human2.19104991
25BP1_19119308_ChIP-ChIP_Hs578T_Human2.18506286
26* MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.16893227
27POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14237737
28GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.09181964
29STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.03907446
30E2F4_17652178_ChIP-ChIP_JURKAT_Human2.03113037
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.01463891
32RUNX_20019798_ChIP-Seq_JUKART_Human2.00943357
33SCL_19346495_ChIP-Seq_HPC-7_Human2.00132206
34ELK1_19687146_ChIP-ChIP_HELA_Human1.99915486
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.99515089
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99326838
37* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.98235648
38* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94467713
39FUS_26573619_Chip-Seq_HEK293_Human1.93099992
40NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93067553
41FOXP3_21729870_ChIP-Seq_TREG_Human1.79617821
42GATA1_22025678_ChIP-Seq_K562_Human1.78570657
43EWS_26573619_Chip-Seq_HEK293_Human1.77989953
44FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.75864017
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.70413359
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69955520
47Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.68400737
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67942384
49* MYB_26560356_Chip-Seq_TH2_Human1.67275555
50LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.66312105
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.65044811
52SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.62890414
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.62081522
54ER_23166858_ChIP-Seq_MCF-7_Human1.61506663
55MYB_21317192_ChIP-Seq_ERMYB_Mouse1.60762741
56FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.58264266
57MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.55820849
58SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.55532689
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.54509112
60* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.53618293
61IRF1_19129219_ChIP-ChIP_H3396_Human1.53552650
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53032596
63STAT4_19710469_ChIP-ChIP_TH1__Mouse1.53007302
64LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.52321267
65ETS1_20019798_ChIP-Seq_JURKAT_Human1.51956593
66STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.49109405
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.48879448
68NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.48283510
69JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.47078870
70PADI4_21655091_ChIP-ChIP_MCF-7_Human1.46425778
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.45775276
72HOXB4_20404135_ChIP-ChIP_EML_Mouse1.43974996
73GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.41719905
74TP53_22573176_ChIP-Seq_HFKS_Human1.38622522
75* MYB_26560356_Chip-Seq_TH1_Human1.36579480
76EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.35466102
77ZFP57_27257070_Chip-Seq_ESCs_Mouse1.35403400
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.32593937
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28063017
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.27049865
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.27049865
82* MYC_18940864_ChIP-ChIP_HL60_Human1.24472567
83* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24159135
84GATA3_26560356_Chip-Seq_TH2_Human1.23296692
85BRD4_27068464_Chip-Seq_AML-cells_Mouse1.23134998
86CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22694674
87P300_19829295_ChIP-Seq_ESCs_Human1.22108501
88GATA3_27048872_Chip-Seq_THYMUS_Human1.21301872
89TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.20364845
90NANOG_19829295_ChIP-Seq_ESCs_Human1.19333963
91SOX2_19829295_ChIP-Seq_ESCs_Human1.19333963
92EZH2_27294783_Chip-Seq_NPCs_Mouse1.18115860
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.18022939
94GATA2_21666600_ChIP-Seq_HMVEC_Human1.17690528
95CTBP2_25329375_ChIP-Seq_LNCAP_Human1.17539267
96NFE2_27457419_Chip-Seq_LIVER_Mouse1.13094649
97SALL4_22934838_ChIP-ChIP_CD34+_Human1.10964502
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.09349527
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.08309203
100PU_27001747_Chip-Seq_BMDM_Mouse1.07443037
101CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06873539
102FLI1_27457419_Chip-Seq_LIVER_Mouse1.06864237
103CIITA_25753668_ChIP-Seq_RAJI_Human1.06001909
104* SPI1_23547873_ChIP-Seq_NB4_Human1.05631457
105CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05014279
106CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04880557
107STAT3_23295773_ChIP-Seq_U87_Human1.04132145
108GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.04027112
109VDR_24787735_ChIP-Seq_THP-1_Human1.03525047
110PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03475961
111NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.03317095
112* AR_20517297_ChIP-Seq_VCAP_Human1.02668457
113FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02628018
114* ERG_20517297_ChIP-Seq_VCAP_Human1.02152797
115RUNX1_22412390_ChIP-Seq_EML_Mouse1.02033764
116GATA1_22383799_ChIP-Seq_G1ME_Mouse1.01647077
117RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.01447075
118MAF_26560356_Chip-Seq_TH1_Human1.01429647
119CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.00855596
120MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.00608716
121PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.98906402
122PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.98799516
123TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.98683777
124EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.97574737
125BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.97523182
126GATA3_21878914_ChIP-Seq_MCF-7_Human0.96492827
127PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.95865371
128TP63_19390658_ChIP-ChIP_HaCaT_Human0.95594227
129SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95022044
130GBX2_23144817_ChIP-Seq_PC3_Human0.94476737
131GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94095811
132E2F1_21310950_ChIP-Seq_MCF-7_Human0.94046901
133CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93961454
134PRDM14_20953172_ChIP-Seq_ESCs_Human0.92925816
135ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91264604
136CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90525692
137RXRA_24833708_ChIP-Seq_LIVER_Mouse0.89872749
138ETS1_22383799_ChIP-Seq_G1ME_Mouse0.88856976
139HTT_18923047_ChIP-ChIP_STHdh_Human0.87809287
140KAP1_22055183_ChIP-Seq_ESCs_Mouse0.86934775
141FOXA2_19822575_ChIP-Seq_HepG2_Human0.86374040
142GATA3_26560356_Chip-Seq_TH1_Human0.86361276
143SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85077306
144TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84322822
145STAT1_17558387_ChIP-Seq_HELA_Human0.84303907
146CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83140656
147TAF15_26573619_Chip-Seq_HEK293_Human0.82847660
148GATA2_19941826_ChIP-Seq_K562_Human0.82305346
149CBP_20019798_ChIP-Seq_JUKART_Human0.82017147
150IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.82017147
151CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81999689
152GATA1_19941827_ChIP-Seq_MEL_Mouse0.81975327
153CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.81717665
154P53_21459846_ChIP-Seq_SAOS-2_Human0.81697835
155STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.81182295
156* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.80992909
157PCGF2_27294783_Chip-Seq_ESCs_Mouse0.79122634
158CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.79063981
159CRX_20693478_ChIP-Seq_RETINA_Mouse0.77994617
160UTX_26944678_Chip-Seq_JUKART_Human0.77730144
161RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.76450829
162E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.76220063
163PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.75854416
164* SOX2_22085726_ChIP-Seq_NPCs_Mouse0.75172542
165* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.74751026
166TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74419221

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.21888590
2MP0005360_urolithiasis4.52997428
3MP0005365_abnormal_bile_salt4.10571590
4MP0008877_abnormal_DNA_methylation3.85673850
5MP0005085_abnormal_gallbladder_physiolo3.84918539
6MP0005410_abnormal_fertilization3.42499552
7MP0008057_abnormal_DNA_replication3.36860119
8MP0008875_abnormal_xenobiotic_pharmacok3.13581339
9MP0003252_abnormal_bile_duct2.94777741
10MP0008058_abnormal_DNA_repair2.65171852
11MP0010329_abnormal_lipoprotein_level2.37615203
12MP0000372_irregular_coat_pigmentation2.31636176
13MP0003646_muscle_fatigue2.30562608
14MP0001835_abnormal_antigen_presentation2.29824236
15MP0010094_abnormal_chromosome_stability2.19297936
16MP0003806_abnormal_nucleotide_metabolis2.18154306
17MP0003191_abnormal_cellular_cholesterol2.02717965
18MP0005083_abnormal_biliary_tract1.91574907
19MP0005332_abnormal_amino_acid1.86304802
20MP0001666_abnormal_nutrient_absorption1.83702115
21MP0002138_abnormal_hepatobiliary_system1.83228248
22MP0005075_abnormal_melanosome_morpholog1.83093868
23MP0000609_abnormal_liver_physiology1.77086055
24MP0005670_abnormal_white_adipose1.75184728
25MP0009785_altered_susceptibility_to1.73894809
26MP0000685_abnormal_immune_system1.71833840
27MP0003724_increased_susceptibility_to1.70821547
28MP0005464_abnormal_platelet_physiology1.70514685
29MP0009840_abnormal_foam_cell1.68401844
30MP0002877_abnormal_melanocyte_morpholog1.66778243
31MP0000569_abnormal_digit_pigmentation1.65109532
32MP0005671_abnormal_response_to1.63171341
33MP0002118_abnormal_lipid_homeostasis1.63143056
34MP0003868_abnormal_feces_composition1.62611363
35MP0002166_altered_tumor_susceptibility1.58124586
36MP0009764_decreased_sensitivity_to1.56179395
37MP0005584_abnormal_enzyme/coenzyme_acti1.55837361
38MP0008995_early_reproductive_senescence1.55611161
39MP0002876_abnormal_thyroid_physiology1.54599453
40MP0003436_decreased_susceptibility_to1.54496422
41MP0001764_abnormal_homeostasis1.53122065
42MP0003195_calcinosis1.50452400
43MP0005319_abnormal_enzyme/_coenzyme1.50146045
44MP0003656_abnormal_erythrocyte_physiolo1.49419517
45MP0004130_abnormal_muscle_cell1.45860476
46MP0005025_abnormal_response_to1.43109000
47MP0003786_premature_aging1.40433348
48MP0001800_abnormal_humoral_immune1.40384211
49MP0003718_maternal_effect1.39819896
50MP0009697_abnormal_copulation1.39233034
51MP0002419_abnormal_innate_immunity1.38122474
52MP0008469_abnormal_protein_level1.37220718
53MP0006054_spinal_hemorrhage1.34905797
54MP0005084_abnormal_gallbladder_morpholo1.32453304
55MP0002722_abnormal_immune_system1.32327245
56MP0005387_immune_system_phenotype1.32275714
57MP0001790_abnormal_immune_system1.32275714
58MP0009643_abnormal_urine_homeostasis1.31851611
59MP0003763_abnormal_thymus_physiology1.31823758
60MP0003693_abnormal_embryo_hatching1.27623912
61MP0001853_heart_inflammation1.26956436
62MP0002723_abnormal_immune_serum1.26953531
63MP0008007_abnormal_cellular_replicative1.25442288
64MP0002095_abnormal_skin_pigmentation1.23919787
65MP0003300_gastrointestinal_ulcer1.23152889
66MP0002210_abnormal_sex_determination1.21239662
67MP0002452_abnormal_antigen_presenting1.20900405
68MP0003011_delayed_dark_adaptation1.19607845
69MP0005266_abnormal_metabolism1.19585748
70MP0003186_abnormal_redox_activity1.19125119
71MP0005551_abnormal_eye_electrophysiolog1.18347080
72MP0003950_abnormal_plasma_membrane1.17920478
73MP0008872_abnormal_physiological_respon1.17748330
74MP0001845_abnormal_inflammatory_respons1.17041357
75MP0005174_abnormal_tail_pigmentation1.16474557
76MP0009333_abnormal_splenocyte_physiolog1.16470315
77MP0000427_abnormal_hair_cycle1.16121502
78MP0002837_dystrophic_cardiac_calcinosis1.15382902
79MP0006035_abnormal_mitochondrial_morpho1.14639232
80MP0005636_abnormal_mineral_homeostasis1.13980014
81MP0001819_abnormal_immune_cell1.13936051
82MP0005220_abnormal_exocrine_pancreas1.13872530
83MP0001873_stomach_inflammation1.13498078
84MP0005645_abnormal_hypothalamus_physiol1.13230791
85MP0004019_abnormal_vitamin_homeostasis1.13220034
86MP0000703_abnormal_thymus_morphology1.13210049
87MP0002420_abnormal_adaptive_immunity1.13038619
88MP0004043_abnormal_pH_regulation1.13024525
89MP0006082_CNS_inflammation1.11411353
90MP0009763_increased_sensitivity_to1.10462232
91MP0004145_abnormal_muscle_electrophysio1.09775949
92MP0002006_tumorigenesis1.08955855
93MP0000598_abnormal_liver_morphology1.08790276
94MP0005000_abnormal_immune_tolerance1.08439977
95MP0005408_hypopigmentation1.07434608
96MP0000653_abnormal_sex_gland1.06939872
97MP0001986_abnormal_taste_sensitivity1.06874659
98MP0006036_abnormal_mitochondrial_physio1.06015757
99MP0003943_abnormal_hepatobiliary_system1.04004993
100MP0002928_abnormal_bile_duct1.03745001
101MP0002148_abnormal_hypersensitivity_rea1.00826255
102MP0010155_abnormal_intestine_physiology1.00701195
103MP0001145_abnormal_male_reproductive1.00056111
104MP0005058_abnormal_lysosome_morphology0.99692237
105MP0006292_abnormal_olfactory_placode0.99579539
106MP0002971_abnormal_brown_adipose0.98853343
107MP0002398_abnormal_bone_marrow0.98623937
108MP0005397_hematopoietic_system_phenotyp0.97815642
109MP0001545_abnormal_hematopoietic_system0.97815642
110MP0004142_abnormal_muscle_tone0.97195958
111MP0004147_increased_porphyrin_level0.95844069
112MP0000015_abnormal_ear_pigmentation0.94828831
113MP0002019_abnormal_tumor_incidence0.94815332
114MP0003787_abnormal_imprinting0.94557306
115MP0001119_abnormal_female_reproductive0.94220392
116MP0002405_respiratory_system_inflammati0.92901904
117MP0000716_abnormal_immune_system0.92000280
118MP0005647_abnormal_sex_gland0.91905658
119MP0003077_abnormal_cell_cycle0.89420689
120MP0002078_abnormal_glucose_homeostasis0.89394160
121MP0005666_abnormal_adipose_tissue0.88892841
122MP0005334_abnormal_fat_pad0.87880037
123MP0009642_abnormal_blood_homeostasis0.87709838
124MP0000689_abnormal_spleen_morphology0.86815736
125MP0008961_abnormal_basal_metabolism0.86404704
126MP0004484_altered_response_of0.86332243
127MP0002009_preneoplasia0.85448669
128MP0000604_amyloidosis0.84858312
129MP0001929_abnormal_gametogenesis0.84627668
130MP0001968_abnormal_touch/_nociception0.83617653
131MP0003698_abnormal_male_reproductive0.82683369
132MP0001661_extended_life_span0.82678566
133MP0002160_abnormal_reproductive_system0.82490518
134MP0003172_abnormal_lysosome_physiology0.82320327
135MP0001765_abnormal_ion_homeostasis0.81858728
136MP0004808_abnormal_hematopoietic_stem0.81257062
137MP0000465_gastrointestinal_hemorrhage0.80824684
138MP0005389_reproductive_system_phenotype0.80789973
139MP0009115_abnormal_fat_cell0.79926484
140MP0005253_abnormal_eye_physiology0.79738921
141MP0002693_abnormal_pancreas_physiology0.79176227
142MP0004947_skin_inflammation0.78427648
143MP0005310_abnormal_salivary_gland0.77449273
144MP0002429_abnormal_blood_cell0.76825015
145MP0002638_abnormal_pupillary_reflex0.76356516
146MP0004957_abnormal_blastocyst_morpholog0.73758400
147MP0002136_abnormal_kidney_physiology0.73353566
148MP0002396_abnormal_hematopoietic_system0.73330383
149MP0001533_abnormal_skeleton_physiology0.72750240
150MP0003111_abnormal_nucleus_morphology0.72644761

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)4.61908886
2Intrahepatic cholestasis (HP:0001406)3.83081433
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.77817515
4Absent/shortened dynein arms (HP:0200106)3.68939046
5Dynein arm defect of respiratory motile cilia (HP:0012255)3.68939046
6Nasal polyposis (HP:0100582)3.68633427
7Deep venous thrombosis (HP:0002625)3.67631401
8Hypobetalipoproteinemia (HP:0003563)3.59503141
9Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.59028655
10Abnormality of B cell number (HP:0010975)3.57806391
11Xanthomatosis (HP:0000991)3.56807060
12Prolonged partial thromboplastin time (HP:0003645)3.53848391
13Panhypogammaglobulinemia (HP:0003139)3.51825808
14Abnormality of the nasal mucosa (HP:0000433)3.35324492
15Severe combined immunodeficiency (HP:0004430)3.34952032
16Abnormality of monocarboxylic acid metabolism (HP:0010996)3.30610156
17B lymphocytopenia (HP:0010976)3.29168271
18Abnormality of fatty-acid metabolism (HP:0004359)3.28083653
19Complement deficiency (HP:0004431)3.27128780
20Congenital stationary night blindness (HP:0007642)3.24005815
21Pancreatic cysts (HP:0001737)3.11376048
22Thyroiditis (HP:0100646)3.06483323
23Ketosis (HP:0001946)3.05292094
24Agammaglobulinemia (HP:0004432)2.96360500
25Fat malabsorption (HP:0002630)2.92688418
26Hyperammonemia (HP:0001987)2.92288909
27Abnormality of the common coagulation pathway (HP:0010990)2.91761904
28Epidermoid cyst (HP:0200040)2.88151636
29Hyperlipoproteinemia (HP:0010980)2.86917837
30Hypoglycemic coma (HP:0001325)2.85303672
31Molar tooth sign on MRI (HP:0002419)2.85232210
32Abnormality of midbrain morphology (HP:0002418)2.85232210
33Abnormality of aspartate family amino acid metabolism (HP:0010899)2.84089634
34Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.83035823
35Abnormality of alanine metabolism (HP:0010916)2.83035823
36Hyperalaninemia (HP:0003348)2.83035823
37Attenuation of retinal blood vessels (HP:0007843)2.77041102
38Joint hemorrhage (HP:0005261)2.76096664
39Abnormality of the intrinsic pathway (HP:0010989)2.73367981
40Abnormal delayed hypersensitivity skin test (HP:0002963)2.72768360
41Abnormality of methionine metabolism (HP:0010901)2.71922602
42Hypolipoproteinemia (HP:0010981)2.69966941
433-Methylglutaconic aciduria (HP:0003535)2.69100316
44Combined immunodeficiency (HP:0005387)2.68027957
45IgG deficiency (HP:0004315)2.64181372
46Recurrent bronchitis (HP:0002837)2.61366853
47Abnormality of glutamine family amino acid metabolism (HP:0010902)2.60993445
48Recurrent sinusitis (HP:0011108)2.60297555
49Pancreatic fibrosis (HP:0100732)2.60220875
50Hypercholesterolemia (HP:0003124)2.58492121
51Bronchitis (HP:0012387)2.58088987
52Conjugated hyperbilirubinemia (HP:0002908)2.55430433
53Abnormal rod and cone electroretinograms (HP:0008323)2.55118606
54Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.55117432
55Chronic bronchitis (HP:0004469)2.53172188
56Recurrent gram-negative bacterial infections (HP:0005420)2.50858383
57Hyperbilirubinemia (HP:0002904)2.49583507
58Absent rod-and cone-mediated responses on ERG (HP:0007688)2.49538847
59Abnormality of sulfur amino acid metabolism (HP:0004339)2.48092204
60Ketoacidosis (HP:0001993)2.47161510
61Renal cortical cysts (HP:0000803)2.46851356
62Hyperglycinuria (HP:0003108)2.46736372
63Loss of speech (HP:0002371)2.45125942
64Steatorrhea (HP:0002570)2.43030185
65Abnormality of dicarboxylic acid metabolism (HP:0010995)2.41931575
66Dicarboxylic aciduria (HP:0003215)2.41931575
67Abnormal respiratory motile cilium physiology (HP:0012261)2.40953613
68Volvulus (HP:0002580)2.40842675
69Nephronophthisis (HP:0000090)2.40809225
70Abnormality of the renal medulla (HP:0100957)2.40808311
71Abnormal glycosylation (HP:0012345)2.40761993
72Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.40761993
73Abnormal protein N-linked glycosylation (HP:0012347)2.40761993
74Abnormal protein glycosylation (HP:0012346)2.40761993
75Gingival bleeding (HP:0000225)2.40153782
76Type I transferrin isoform profile (HP:0003642)2.37991229
77Abnormal spermatogenesis (HP:0008669)2.37980130
78Azoospermia (HP:0000027)2.35849279
79Abnormality of eosinophils (HP:0001879)2.35366427
80Abnormality of macular pigmentation (HP:0008002)2.34647516
81Myocardial infarction (HP:0001658)2.32835722
82Abnormality of the prostate (HP:0008775)2.32755704
83Abnormality of complement system (HP:0005339)2.32017186
84Abnormality of T cell physiology (HP:0011840)2.28351362
85Medial flaring of the eyebrow (HP:0010747)2.27598200
86Stomatitis (HP:0010280)2.27479774
87Hypoalphalipoproteinemia (HP:0003233)2.27229770
88Decreased central vision (HP:0007663)2.26649773
89Acute lymphatic leukemia (HP:0006721)2.24951819
90Stomach cancer (HP:0012126)2.24909584
91Generalized aminoaciduria (HP:0002909)2.24570635
92Abnormal biliary tract physiology (HP:0012439)2.23532413
93Bile duct proliferation (HP:0001408)2.23532413
94Infertility (HP:0000789)2.21739543
95Eosinophilia (HP:0001880)2.20820172
96Abnormality of serine family amino acid metabolism (HP:0010894)2.18337585
97Abnormality of glycine metabolism (HP:0010895)2.18337585
98Central scotoma (HP:0000603)2.15822357
99True hermaphroditism (HP:0010459)2.14892079
100Epistaxis (HP:0000421)2.14766923
101Spontaneous hematomas (HP:0007420)2.14762465
102Purpura (HP:0000979)2.14042265
103Progressive inability to walk (HP:0002505)2.13935944
104Increased CSF lactate (HP:0002490)2.13103707
105Chronic otitis media (HP:0000389)2.12796467
106Pancreatitis (HP:0001733)2.12227370
107Granulocytopenia (HP:0001913)2.12136306
108Abnormality of purine metabolism (HP:0004352)2.11395863
109Abnormality of chromosome stability (HP:0003220)2.10914911
110Elevated erythrocyte sedimentation rate (HP:0003565)2.10834948
111Proximal tubulopathy (HP:0000114)2.08004400
112Abolished electroretinogram (ERG) (HP:0000550)2.07498449
113Recurrent fungal infections (HP:0002841)2.06928768
114Encephalitis (HP:0002383)2.06225149
115Systemic lupus erythematosus (HP:0002725)2.05473587
116Spontaneous abortion (HP:0005268)2.04434947
117Abnormal respiratory epithelium morphology (HP:0012253)2.04390329
118Abnormal respiratory motile cilium morphology (HP:0005938)2.04390329
119Hypoplasia of the thymus (HP:0000778)2.04184929
120Hemorrhage of the eye (HP:0011885)2.03640203
121Bronchiectasis (HP:0002110)2.02358283
122Abnormality of T cells (HP:0002843)2.01413502
123Metabolic acidosis (HP:0001942)1.99747601
124Hypoproteinemia (HP:0003075)1.99417341
125Clubbing of toes (HP:0100760)1.98916495
126Aplasia/Hypoplasia of the fovea (HP:0008060)1.98011711
127Hypoplasia of the fovea (HP:0007750)1.98011711
128Hyperglycinemia (HP:0002154)1.97717442
129Hypertriglyceridemia (HP:0002155)1.97251820
130Acanthocytosis (HP:0001927)1.95364360
131Eczematoid dermatitis (HP:0000976)1.95355666
132Rhinitis (HP:0012384)1.95097297
133Increased serum lactate (HP:0002151)1.94595089
134Aplasia/Hypoplasia of the uvula (HP:0010293)1.94485177
135Abnormality of nucleobase metabolism (HP:0010932)1.94275526
136Prolonged bleeding time (HP:0003010)1.92697418
137Myoglobinuria (HP:0002913)1.91279215
138Sloping forehead (HP:0000340)1.91165702
139Acute necrotizing encephalopathy (HP:0006965)1.89796696
140Autoimmune hemolytic anemia (HP:0001890)1.89733473
141Constricted visual fields (HP:0001133)1.88825845
142Recurrent bacterial skin infections (HP:0005406)1.88381096
143Lethargy (HP:0001254)1.87508459
144Chronic diarrhea (HP:0002028)1.87484432
145Pulmonary embolism (HP:0002204)1.87011392
146Autoimmune thrombocytopenia (HP:0001973)1.86358165
147Chromsome breakage (HP:0040012)1.85896094
148Reduced antithrombin III activity (HP:0001976)1.85695315
149Asymmetric septal hypertrophy (HP:0001670)1.85607246
150Gaze-evoked nystagmus (HP:0000640)1.84610909
151Malnutrition (HP:0004395)1.84179881
152T lymphocytopenia (HP:0005403)1.83790178
153Chromosomal breakage induced by crosslinking agents (HP:0003221)1.83727775
154Abnormality of the renal cortex (HP:0011035)1.83021110
155* Elevated hepatic transaminases (HP:0002910)1.81702507
156Mitochondrial inheritance (HP:0001427)1.81523367
157Abnormality of the fovea (HP:0000493)1.80873917
158Acute encephalopathy (HP:0006846)1.80562135
159Menorrhagia (HP:0000132)1.80341381
160Abnormality of T cell number (HP:0011839)1.80088418
161Abnormality of serum amino acid levels (HP:0003112)1.79332630
162Hepatic necrosis (HP:0002605)1.79032853
163Recurrent viral infections (HP:0004429)1.78765176
164Increased neuronal autofluorescent lipopigment (HP:0002074)1.78549332
165Chronic hepatic failure (HP:0100626)1.78201789
166Acute myeloid leukemia (HP:0004808)1.78110934
167Recurrent cutaneous fungal infections (HP:0011370)1.77961046
168Chronic mucocutaneous candidiasis (HP:0002728)1.77961046
169Abnormality of the pons (HP:0007361)1.77898704
170Thrombophlebitis (HP:0004418)1.77675248
171Joint swelling (HP:0001386)1.77290807
172Impaired platelet aggregation (HP:0003540)1.77245004
173Abnormal platelet function (HP:0011869)1.77245004
174Decreased activity of mitochondrial respiratory chain (HP:0008972)1.76303001
175Abnormality of the ileum (HP:0001549)1.75489414
176Progressive macrocephaly (HP:0004481)1.73932735
177IgM deficiency (HP:0002850)1.73288337
178Abnormality of the preputium (HP:0100587)1.73269812
179Myelodysplasia (HP:0002863)1.73233714
180Lactic acidosis (HP:0003128)1.72842307
181Decreased electroretinogram (ERG) amplitude (HP:0000654)1.71408216
182Abnormal mitochondria in muscle tissue (HP:0008316)1.71214745
183Chronic sinusitis (HP:0011109)1.69712718
184Brushfield spots (HP:0001088)1.69645028
185Nephrogenic diabetes insipidus (HP:0009806)1.68846321
186Prostate neoplasm (HP:0100787)1.67408038
187Birth length less than 3rd percentile (HP:0003561)1.67071853

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK33.96219339
2PDK43.96219339
3EIF2AK33.50501654
4NUAK13.42904737
5BCKDK3.17528078
6TAOK32.86853893
7ERN12.80522838
8FRK2.71479882
9MAP4K12.64318010
10TXK2.39333050
11PDK22.32409066
12MAP3K132.14028230
13TESK12.09737754
14ZAP702.08579042
15BMPR1B2.06183929
16BMPR22.00101910
17TYK21.97299677
18ZAK1.92181961
19FGFR41.83753852
20IKBKE1.81784760
21TLK11.73231869
22TEC1.70198908
23INSRR1.68197427
24FLT31.65579850
25JAK31.65211593
26NEK91.61581970
27RIPK41.59625391
28EEF2K1.57987336
29PLK41.54711921
30LATS11.53977148
31PIK3CA1.51868618
32TBK11.51504212
33MUSK1.49825474
34MAP3K141.49708014
35KIT1.47808871
36BLK1.47805112
37MAPKAPK31.41531656
38ACVR1B1.41214031
39WNK31.40412814
40JAK11.38997355
41MAP4K21.37260454
42VRK11.34900138
43TGFBR21.25741938
44OBSCN1.24278792
45MAPK111.22796455
46ITK1.21524358
47MAPK131.21008432
48PDK11.20907094
49MKNK11.20150872
50SIK11.19874007
51BTK1.17986006
52PRKD31.17544803
53CDC71.17142624
54NLK1.14954175
55FGFR31.12748025
56EPHA31.12598994
57EIF2AK11.12487450
58CSF1R1.10443490
59PIK3CG1.04378905
60EIF2AK21.00276607
61IRAK40.98947483
62CCNB10.96748056
63STK100.96567529
64GRK10.95041136
65STK30.94810091
66MKNK20.94429282
67MAP3K70.94205782
68SYK0.93081716
69ATR0.91929215
70MAPK150.91905992
71OXSR10.91858373
72MST40.91552861
73KDR0.90708722
74CDK80.84140525
75LCK0.83831982
76PRKCQ0.83602254
77WNK40.82403182
78CSK0.81907908
79WEE10.81903746
80IKBKB0.80896183
81PRKAA20.80751562
82MAP2K30.80287206
83PDPK10.77233236
84SRPK10.77192450
85PTK2B0.77039706
86STK390.74673509
87EPHB10.74488798
88JAK20.74446796
89TIE10.72883264
90STK38L0.72856621
91IRAK10.72780284
92BUB10.72467034
93PRKCH0.71747923
94CDK30.71474130
95NEK20.71458891
96FES0.71016617
97TRIB30.70761659
98TRIM280.70073633
99TNK20.69954353
100LYN0.69747875
101RPS6KA60.68190878
102MAP2K60.66565491
103RPS6KA40.66510782
104VRK20.65561476
105PTK60.65101851
106PRKD20.65037274
107RPS6KB10.64002291
108PNCK0.63940089
109ARAF0.63394282
110PIM10.60612993
111FGFR20.59948136
112MAPKAPK50.59588522
113ATM0.59036572
114MAP3K120.57365353
115RPS6KB20.57259862
116NME10.56665553
117TRPM70.55950945
118MAP3K50.55921546
119PLK30.55094769
120IRAK30.54428794
121CHEK20.52738601
122MAP2K70.51644636
123MAP3K40.50584611
124ERBB40.49428938
125MAP3K60.48837305
126MAP3K10.46472146
127HCK0.45682663
128CDK40.45192453
129LMTK20.43831116
130CAMK1D0.42987425
131RPS6KA50.42100600
132GRK60.40881420
133MAPK120.40777591
134IGF1R0.40130915
135PRKG20.39807503
136MARK30.39258134
137MYLK0.39175929
138LRRK20.38040177
139RAF10.37786256
140ABL10.37172926
141PINK10.36821947
142MATK0.36770537
143SCYL20.36302346
144BRSK20.35685907
145PLK10.34765189
146MAPK40.34447827
147ADRBK10.34406836
148MAP2K40.34383604
149STK160.33661267
150ADRBK20.32644917
151CDK190.32356202
152STK40.30844095
153TTK0.30487401

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.45218897
2Fatty acid degradation_Homo sapiens_hsa000713.11517995
3Homologous recombination_Homo sapiens_hsa034403.05854670
4Propanoate metabolism_Homo sapiens_hsa006403.04136561
5Proteasome_Homo sapiens_hsa030502.95663430
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.62166034
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.50548649
8Fanconi anemia pathway_Homo sapiens_hsa034602.50540853
9Non-homologous end-joining_Homo sapiens_hsa034502.42705978
10Fatty acid metabolism_Homo sapiens_hsa012122.39451305
11Tryptophan metabolism_Homo sapiens_hsa003802.38283623
12Peroxisome_Homo sapiens_hsa041462.26958721
13PPAR signaling pathway_Homo sapiens_hsa033202.25043493
14Nitrogen metabolism_Homo sapiens_hsa009102.24297829
15Pyruvate metabolism_Homo sapiens_hsa006202.22911088
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.16497947
17Complement and coagulation cascades_Homo sapiens_hsa046102.16111285
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.11731622
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.97049092
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.96945629
21Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.96418047
22Mismatch repair_Homo sapiens_hsa034301.95664220
23Caffeine metabolism_Homo sapiens_hsa002321.95622521
24Graft-versus-host disease_Homo sapiens_hsa053321.92478617
25Allograft rejection_Homo sapiens_hsa053301.91897123
26Asthma_Homo sapiens_hsa053101.90827148
27Base excision repair_Homo sapiens_hsa034101.90206550
28Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.87582669
29Sulfur metabolism_Homo sapiens_hsa009201.84327170
30Staphylococcus aureus infection_Homo sapiens_hsa051501.81528190
31RNA polymerase_Homo sapiens_hsa030201.79054065
32Arginine biosynthesis_Homo sapiens_hsa002201.74573318
33beta-Alanine metabolism_Homo sapiens_hsa004101.70149702
34Basal transcription factors_Homo sapiens_hsa030221.66433445
35DNA replication_Homo sapiens_hsa030301.64147349
36Autoimmune thyroid disease_Homo sapiens_hsa053201.63511009
37Selenocompound metabolism_Homo sapiens_hsa004501.62792984
38Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.62670757
39Butanoate metabolism_Homo sapiens_hsa006501.57441763
40Fatty acid biosynthesis_Homo sapiens_hsa000611.56923788
41ABC transporters_Homo sapiens_hsa020101.56843152
42Histidine metabolism_Homo sapiens_hsa003401.56773729
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.54782716
44One carbon pool by folate_Homo sapiens_hsa006701.52692083
45RNA degradation_Homo sapiens_hsa030181.47255077
46Type I diabetes mellitus_Homo sapiens_hsa049401.45267993
47Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45262193
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.45240872
49Chemical carcinogenesis_Homo sapiens_hsa052041.44197637
50Fatty acid elongation_Homo sapiens_hsa000621.41652858
51Nucleotide excision repair_Homo sapiens_hsa034201.40108399
52Phototransduction_Homo sapiens_hsa047441.35834290
53Fat digestion and absorption_Homo sapiens_hsa049751.34732271
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.34453967
55Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.32250165
56RNA transport_Homo sapiens_hsa030131.31682190
57Ether lipid metabolism_Homo sapiens_hsa005651.31474831
58Starch and sucrose metabolism_Homo sapiens_hsa005001.29058045
59Glycerolipid metabolism_Homo sapiens_hsa005611.27799390
60Folate biosynthesis_Homo sapiens_hsa007901.25877035
61Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24747846
62Retinol metabolism_Homo sapiens_hsa008301.21020134
63Drug metabolism - other enzymes_Homo sapiens_hsa009831.19002007
64Regulation of autophagy_Homo sapiens_hsa041401.17854974
65Pyrimidine metabolism_Homo sapiens_hsa002401.15722237
66Carbon metabolism_Homo sapiens_hsa012001.14357831
67Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.14069392
68NOD-like receptor signaling pathway_Homo sapiens_hsa046211.14006044
69Oxidative phosphorylation_Homo sapiens_hsa001901.13179465
70Purine metabolism_Homo sapiens_hsa002301.09426343
71Parkinsons disease_Homo sapiens_hsa050121.09092238
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08975335
73Maturity onset diabetes of the young_Homo sapiens_hsa049501.06532192
74Steroid hormone biosynthesis_Homo sapiens_hsa001401.06510742
75Primary immunodeficiency_Homo sapiens_hsa053401.03517191
76Bile secretion_Homo sapiens_hsa049761.03396669
77Vitamin B6 metabolism_Homo sapiens_hsa007500.97378112
78Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.95569512
79Pentose phosphate pathway_Homo sapiens_hsa000300.91939711
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.91790618
81Vitamin digestion and absorption_Homo sapiens_hsa049770.91581056
82Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.89780313
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.88747392
84Olfactory transduction_Homo sapiens_hsa047400.88587328
85Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84035521
86Herpes simplex infection_Homo sapiens_hsa051680.83778155
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.82781712
88Rheumatoid arthritis_Homo sapiens_hsa053230.81000865
89Arachidonic acid metabolism_Homo sapiens_hsa005900.80733465
90Protein export_Homo sapiens_hsa030600.79727605
91* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77455268
92alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75102828
93Phenylalanine metabolism_Homo sapiens_hsa003600.74233630
94Sulfur relay system_Homo sapiens_hsa041220.72509124
95Spliceosome_Homo sapiens_hsa030400.70855842
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70592848
97Adipocytokine signaling pathway_Homo sapiens_hsa049200.69567955
98Insulin resistance_Homo sapiens_hsa049310.69273961
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.68615414
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.68598379
101Measles_Homo sapiens_hsa051620.68582222
102Tyrosine metabolism_Homo sapiens_hsa003500.66189722
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65055930
104Cell cycle_Homo sapiens_hsa041100.64388447
105Huntingtons disease_Homo sapiens_hsa050160.64067587
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.61139768
107Biosynthesis of amino acids_Homo sapiens_hsa012300.60680731
108Glucagon signaling pathway_Homo sapiens_hsa049220.60610500
109Arginine and proline metabolism_Homo sapiens_hsa003300.58321212
110Steroid biosynthesis_Homo sapiens_hsa001000.57205499
111Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.57204674
112Linoleic acid metabolism_Homo sapiens_hsa005910.56808326
113Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.55762946
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.55350467
115Glutathione metabolism_Homo sapiens_hsa004800.54645248
116Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.54385498
117Antigen processing and presentation_Homo sapiens_hsa046120.53736116
118Legionellosis_Homo sapiens_hsa051340.53606483
119Other glycan degradation_Homo sapiens_hsa005110.51776501
120Epstein-Barr virus infection_Homo sapiens_hsa051690.50144754
121N-Glycan biosynthesis_Homo sapiens_hsa005100.48096152
122Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.47069585
123Taste transduction_Homo sapiens_hsa047420.46976904
124Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46000885
125B cell receptor signaling pathway_Homo sapiens_hsa046620.44329391
126Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.43083073
127Systemic lupus erythematosus_Homo sapiens_hsa053220.41912531
128Metabolic pathways_Homo sapiens_hsa011000.41629027
129Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41399537
130NF-kappa B signaling pathway_Homo sapiens_hsa040640.40335879
131Lysine degradation_Homo sapiens_hsa003100.39831819
132SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39432430
133Alzheimers disease_Homo sapiens_hsa050100.38904599
134Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37794245
135Ribosome_Homo sapiens_hsa030100.36707539
136mRNA surveillance pathway_Homo sapiens_hsa030150.35067797
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33786087
138Hematopoietic cell lineage_Homo sapiens_hsa046400.33378359
139Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.33118920
140Osteoclast differentiation_Homo sapiens_hsa043800.32675731
141Lysosome_Homo sapiens_hsa041420.32672009
142Leishmaniasis_Homo sapiens_hsa051400.31568411
143Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.30342801
144TNF signaling pathway_Homo sapiens_hsa046680.30199884
145Jak-STAT signaling pathway_Homo sapiens_hsa046300.30138709
146Glycerophospholipid metabolism_Homo sapiens_hsa005640.28966601
147T cell receptor signaling pathway_Homo sapiens_hsa046600.28817920
148Influenza A_Homo sapiens_hsa051640.27029065
149Toxoplasmosis_Homo sapiens_hsa051450.26420485
150Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25646604

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