NGRN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)6.74892062
2synaptic vesicle maturation (GO:0016188)5.67079329
3glutamate secretion (GO:0014047)5.21398597
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.13283914
5synaptic vesicle docking involved in exocytosis (GO:0016081)5.03922021
6ribosomal small subunit assembly (GO:0000028)4.99056978
7synaptic vesicle exocytosis (GO:0016079)4.93054739
8pyrimidine nucleobase catabolic process (GO:0006208)4.81543985
9regulation of synaptic vesicle exocytosis (GO:2000300)4.55435969
10postsynaptic membrane organization (GO:0001941)4.44161286
11oxidative phosphorylation (GO:0006119)4.42013434
12viral transcription (GO:0019083)4.40429802
13translational termination (GO:0006415)4.39679355
14positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.24477294
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.22000336
16translational elongation (GO:0006414)4.19791721
17neurotransmitter secretion (GO:0007269)4.18644818
18protein insertion into membrane (GO:0051205)4.18553337
19protein localization to synapse (GO:0035418)4.16329957
20membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.15915251
21vocalization behavior (GO:0071625)4.12524423
22ribosomal small subunit biogenesis (GO:0042274)4.11189474
23establishment of mitochondrion localization (GO:0051654)4.07922738
24SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.07495870
25positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.05468254
26maturation of SSU-rRNA (GO:0030490)4.05087526
27neuron cell-cell adhesion (GO:0007158)4.03204274
28proteasome assembly (GO:0043248)4.01927962
29regulation of synaptic vesicle transport (GO:1902803)4.00395482
30protein targeting to ER (GO:0045047)3.99014805
31cotranslational protein targeting to membrane (GO:0006613)3.96345160
32nucleobase catabolic process (GO:0046113)3.93298685
33neuronal action potential propagation (GO:0019227)3.92885079
34deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.90274426
35regulation of synapse structural plasticity (GO:0051823)3.83878136
36protein localization to endoplasmic reticulum (GO:0070972)3.82302941
37formation of translation preinitiation complex (GO:0001731)3.81270906
38locomotory exploration behavior (GO:0035641)3.80358709
39purine nucleobase biosynthetic process (GO:0009113)3.79857304
40establishment of protein localization to endoplasmic reticulum (GO:0072599)3.77241135
41metallo-sulfur cluster assembly (GO:0031163)3.75514118
42iron-sulfur cluster assembly (GO:0016226)3.75514118
43translational initiation (GO:0006413)3.73079957
44energy coupled proton transport, down electrochemical gradient (GO:0015985)3.69980341
45ATP synthesis coupled proton transport (GO:0015986)3.69980341
46regulation of mitochondrial translation (GO:0070129)3.69793990
47cellular potassium ion homeostasis (GO:0030007)3.67686163
48gamma-aminobutyric acid transport (GO:0015812)3.67255712
49ribosomal large subunit biogenesis (GO:0042273)3.65964618
50axonal fasciculation (GO:0007413)3.65519204
51exploration behavior (GO:0035640)3.64112852
52ionotropic glutamate receptor signaling pathway (GO:0035235)3.63454787
53regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.63217114
54negative regulation of synaptic transmission, GABAergic (GO:0032229)3.63146212
55neuron recognition (GO:0008038)3.61074994
56viral life cycle (GO:0019058)3.59326901
57nucleobase biosynthetic process (GO:0046112)3.57240678
58neuronal ion channel clustering (GO:0045161)3.55241734
59cell migration in hindbrain (GO:0021535)3.55100298
60synaptic transmission, glutamatergic (GO:0035249)3.55037716
61sensory perception of smell (GO:0007608)3.53521747
62DNA strand elongation involved in DNA replication (GO:0006271)3.51728386
63neurotransmitter-gated ion channel clustering (GO:0072578)3.51122193
64translation (GO:0006412)3.49020984
65presynaptic membrane organization (GO:0097090)3.48231490
66folic acid-containing compound biosynthetic process (GO:0009396)3.47216566
67ribonucleoprotein complex biogenesis (GO:0022613)3.46909435
68presynaptic membrane assembly (GO:0097105)3.46780093
69nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.46514704
70pteridine-containing compound biosynthetic process (GO:0042559)3.45892777
71dendritic spine morphogenesis (GO:0060997)3.44329470
72cellular protein complex disassembly (GO:0043624)3.44110440
73negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.38234006
74DNA strand elongation (GO:0022616)3.35358399
75GMP metabolic process (GO:0046037)3.31972483
76regulation of neuronal synaptic plasticity (GO:0048168)3.31193415
77positive regulation of synapse maturation (GO:0090129)3.30268542
78rRNA modification (GO:0000154)3.30123359
79sodium ion export (GO:0071436)3.30085850
80auditory behavior (GO:0031223)3.29980985
81transcription elongation from RNA polymerase III promoter (GO:0006385)3.29652361
82termination of RNA polymerase III transcription (GO:0006386)3.29652361
83ribosome biogenesis (GO:0042254)3.28671801
84spliceosomal snRNP assembly (GO:0000387)3.28163262
85synaptic vesicle endocytosis (GO:0048488)3.27812014
86chaperone-mediated protein transport (GO:0072321)3.26419869
87cellular component biogenesis (GO:0044085)3.26112812
88layer formation in cerebral cortex (GO:0021819)3.25468654
89protein complex biogenesis (GO:0070271)3.24317397
90DNA replication initiation (GO:0006270)3.23342508
91respiratory chain complex IV assembly (GO:0008535)3.22959955
92mitochondrial respiratory chain complex I assembly (GO:0032981)3.21195927
93NADH dehydrogenase complex assembly (GO:0010257)3.21195927
94mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.21195927
95mitochondrial respiratory chain complex assembly (GO:0033108)3.20991682
96neurotransmitter transport (GO:0006836)3.20968287
97regulation of neurotransmitter levels (GO:0001505)3.20463505
98GDP-mannose metabolic process (GO:0019673)3.19711955
99misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.19426803
100positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.19106588
101guanosine-containing compound biosynthetic process (GO:1901070)3.17327607
102neuromuscular synaptic transmission (GO:0007274)3.17310327
103L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.17259584
104neuron-neuron synaptic transmission (GO:0007270)3.17252557
105inner mitochondrial membrane organization (GO:0007007)3.16348197
106positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.14115821
107regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.11994030
108mitochondrion transport along microtubule (GO:0047497)3.11599310
109establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.11599310
110regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.10815314
111telomere maintenance via semi-conservative replication (GO:0032201)3.10759044
112pseudouridine synthesis (GO:0001522)3.10391614
113ribosome assembly (GO:0042255)3.10043189
114rRNA processing (GO:0006364)3.08745590
115cerebellar granule cell differentiation (GO:0021707)3.08281020
116establishment of integrated proviral latency (GO:0075713)3.07106213
117regulation of voltage-gated calcium channel activity (GO:1901385)3.06818462
118respiratory electron transport chain (GO:0022904)3.06474930
119transmission of nerve impulse (GO:0019226)3.06442174
120regulation of glutamate receptor signaling pathway (GO:1900449)3.05440799
121anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.05438767
122neurofilament cytoskeleton organization (GO:0060052)3.05309478
123establishment of protein localization to mitochondrion (GO:0072655)3.05102155
124glutamate receptor signaling pathway (GO:0007215)3.04773509
125protein complex disassembly (GO:0043241)3.04588314
126protein-cofactor linkage (GO:0018065)3.04172123
127electron transport chain (GO:0022900)3.03572894
128galactose catabolic process (GO:0019388)3.02465769
129negative regulation of ligase activity (GO:0051352)3.01906824
130negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.01906824
131regulation of vesicle fusion (GO:0031338)3.01398973
132macromolecular complex disassembly (GO:0032984)3.00676608
133synapse assembly (GO:0007416)3.00351108
134protein targeting to mitochondrion (GO:0006626)2.99686710
135rRNA metabolic process (GO:0016072)2.98137834
136folic acid metabolic process (GO:0046655)2.97292466
137axon ensheathment in central nervous system (GO:0032291)2.93969792
138central nervous system myelination (GO:0022010)2.93969792
139regulation of cellular amino acid metabolic process (GO:0006521)2.93949387
140exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.93253313
141regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.92479009
142positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.90173728
143DNA replication checkpoint (GO:0000076)2.89926131
144protein deneddylation (GO:0000338)2.89505715
145regulation of neurotransmitter secretion (GO:0046928)2.89014999
146regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.88633089
147mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.87572339
148cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.86848777
149dendrite morphogenesis (GO:0048813)2.85548283
150negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.84075241
151positive regulation of membrane potential (GO:0045838)2.83330416
152regulation of dendritic spine morphogenesis (GO:0061001)2.82152210
153positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.81906697
154tRNA aminoacylation for protein translation (GO:0006418)2.81787790
155pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.81314720
156NADH metabolic process (GO:0006734)2.80771359
157amino acid activation (GO:0043038)2.80741354
158tRNA aminoacylation (GO:0043039)2.80741354
159protein localization to mitochondrion (GO:0070585)2.80568568
160cell communication by electrical coupling (GO:0010644)2.79596000
161amino acid salvage (GO:0043102)2.78674192
162L-methionine salvage (GO:0071267)2.78674192
163L-methionine biosynthetic process (GO:0071265)2.78674192
164positive regulation of synapse assembly (GO:0051965)2.78132767
165behavioral response to cocaine (GO:0048148)2.77099320
166dendritic spine organization (GO:0097061)2.76906016
167DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.76763792
168response to auditory stimulus (GO:0010996)2.76479907
169regulation of long-term neuronal synaptic plasticity (GO:0048169)2.76370492
170adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.75977620
171positive regulation of dendritic spine development (GO:0060999)2.75769020
172nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.73519668
173signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.73304843
174intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.73304843
175regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.72616984
176positive regulation of ligase activity (GO:0051351)2.72123971
177regulation of excitatory postsynaptic membrane potential (GO:0060079)2.71669936
178DNA unwinding involved in DNA replication (GO:0006268)2.71579095
179regulation of neurotransmitter transport (GO:0051588)2.71436519
180nuclear-transcribed mRNA catabolic process (GO:0000956)2.71347367
181synapse organization (GO:0050808)2.70614435
182regulation of synapse maturation (GO:0090128)2.70212558
183membrane depolarization during action potential (GO:0086010)2.69722982
184regulation of postsynaptic membrane potential (GO:0060078)2.67054678
185positive regulation of dendritic spine morphogenesis (GO:0061003)2.61186329
186establishment of synaptic vesicle localization (GO:0097480)2.60521301
187synaptic vesicle transport (GO:0048489)2.60521301
188adult walking behavior (GO:0007628)2.59175819
189mechanosensory behavior (GO:0007638)2.58557649
190regulation of respiratory system process (GO:0044065)2.57361411
191positive regulation of neurotransmitter transport (GO:0051590)2.57182723
192positive regulation of mitochondrial fission (GO:0090141)2.56666994
193behavioral response to nicotine (GO:0035095)2.56468603
194potassium ion homeostasis (GO:0055075)2.55543196
195neuromuscular process controlling balance (GO:0050885)2.54657866
196regulation of synaptic plasticity (GO:0048167)2.54098155
197membrane hyperpolarization (GO:0060081)2.52396236
198cellular sodium ion homeostasis (GO:0006883)2.51943522
199detection of calcium ion (GO:0005513)2.51691131
200axon cargo transport (GO:0008088)2.50500876

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.70280013
2NR4A2_19515692_ChIP-ChIP_MN9D_Mouse4.83662265
3* MYC_18555785_ChIP-Seq_MESCs_Mouse4.30705161
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.17934305
5E2F7_22180533_ChIP-Seq_HELA_Human3.85901258
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.73991452
7* GABP_17652178_ChIP-ChIP_JURKAT_Human3.65549798
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.64947375
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.31989995
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.30721481
11EST1_17652178_ChIP-ChIP_JURKAT_Human3.17521199
12CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons3.15975204
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.10215915
14NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.95496412
15REST_21632747_ChIP-Seq_MESCs_Mouse2.88034384
16EZH2_27304074_Chip-Seq_ESCs_Mouse2.70617495
17* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70420513
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.68348561
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.68043907
20XRN2_22483619_ChIP-Seq_HELA_Human2.66436720
21JARID2_20064375_ChIP-Seq_MESCs_Mouse2.66386443
22ELF1_17652178_ChIP-ChIP_JURKAT_Human2.64824442
23CREB1_15753290_ChIP-ChIP_HEK293T_Human2.59530589
24REST_18959480_ChIP-ChIP_MESCs_Mouse2.59189052
25ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.51044592
26JARID2_20075857_ChIP-Seq_MESCs_Mouse2.43781293
27VDR_23849224_ChIP-Seq_CD4+_Human2.42306222
28GBX2_23144817_ChIP-Seq_PC3_Human2.42240427
29* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.41196538
30* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.40719187
31EED_16625203_ChIP-ChIP_MESCs_Mouse2.40414643
32SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.39160803
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.39093536
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.38632573
35EZH2_27294783_Chip-Seq_ESCs_Mouse2.34653414
36EZH2_18974828_ChIP-Seq_MESCs_Mouse2.32840399
37RNF2_18974828_ChIP-Seq_MESCs_Mouse2.32840399
38* GABP_19822575_ChIP-Seq_HepG2_Human2.30073582
39THAP11_20581084_ChIP-Seq_MESCs_Mouse2.27970182
40RARB_27405468_Chip-Seq_BRAIN_Mouse2.27509852
41SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26930702
42DCP1A_22483619_ChIP-Seq_HELA_Human2.22602299
43SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22051756
44SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.17656071
45SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.17350474
46FOXP3_21729870_ChIP-Seq_TREG_Human2.16935840
47NELFA_20434984_ChIP-Seq_ESCs_Mouse2.16085412
48RNF2_27304074_Chip-Seq_ESCs_Mouse2.12781462
49SRF_21415370_ChIP-Seq_HL-1_Mouse2.12321861
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.09477972
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.06552375
52MTF2_20144788_ChIP-Seq_MESCs_Mouse2.03409663
53E2F4_17652178_ChIP-ChIP_JURKAT_Human2.02893594
54DROSHA_22980978_ChIP-Seq_HELA_Human2.01409725
55CBX2_27304074_Chip-Seq_ESCs_Mouse2.00186523
56FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.98154512
57ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.95167904
58SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.93356199
59TTF2_22483619_ChIP-Seq_HELA_Human1.91746143
60YY1_21170310_ChIP-Seq_MESCs_Mouse1.91219562
61E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.90263243
62GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.88597530
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.86401454
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.85059233
65SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.83219575
66* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.82048815
67* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.81259599
68TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.80002644
69RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.74312364
70RNF2_27304074_Chip-Seq_NSC_Mouse1.70575070
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.70467679
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.67635633
73EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67132081
74PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.66542556
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65999256
76NANOG_18555785_ChIP-Seq_MESCs_Mouse1.64333763
77CIITA_25753668_ChIP-Seq_RAJI_Human1.63493762
78RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.61150213
79MYCN_18555785_ChIP-Seq_MESCs_Mouse1.59341553
80MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.59057636
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.55460857
82* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.55361205
83BMI1_23680149_ChIP-Seq_NPCS_Mouse1.51612300
84HOXB4_20404135_ChIP-ChIP_EML_Mouse1.51074754
85ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.50634579
86* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.47021540
87YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.46905558
88ZFP57_27257070_Chip-Seq_ESCs_Mouse1.46895570
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45687911
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.45536769
91SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.45328640
92ERG_21242973_ChIP-ChIP_JURKAT_Human1.45227365
93MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.44991696
94RING1B_27294783_Chip-Seq_ESCs_Mouse1.44142350
95SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.43541618
96CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.42872457
97MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.42058593
98KDM5A_27292631_Chip-Seq_BREAST_Human1.41238611
99RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.39754233
100PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.38241887
101POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.37725961
102OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.36289347
103IGF1R_20145208_ChIP-Seq_DFB_Human1.35402814
104MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.30865636
105ZFP281_18757296_ChIP-ChIP_E14_Mouse1.29388301
106MYC_22102868_ChIP-Seq_BL_Human1.29072113
107SRY_22984422_ChIP-ChIP_TESTIS_Rat1.28824113
108BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.28063134
109AR_21572438_ChIP-Seq_LNCaP_Human1.24665055
110STAT3_1855785_ChIP-Seq_MESCs_Mouse1.23759659
111POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21505144
112* E2F1_21310950_ChIP-Seq_MCF-7_Human1.20547320
113DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20318347
114GATA1_26923725_Chip-Seq_HPCs_Mouse1.19592329
115CTCF_18555785_ChIP-Seq_MESCs_Mouse1.19441916
116ZNF263_19887448_ChIP-Seq_K562_Human1.19265672
117CTBP1_25329375_ChIP-Seq_LNCAP_Human1.19132104
118FOXM1_23109430_ChIP-Seq_U2OS_Human1.18074800
119DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.15964954
120CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.15834822
121ELK1_19687146_ChIP-ChIP_HELA_Human1.14459588
122KLF4_18555785_ChIP-Seq_MESCs_Mouse1.14092180
123CTCF_27219007_Chip-Seq_Bcells_Human1.13376514
124TAF15_26573619_Chip-Seq_HEK293_Human1.12937090
125PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12138087
126SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.12008644
127TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10177088
128TP53_20018659_ChIP-ChIP_R1E_Mouse1.09431680
129IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07212846
130RING1B_27294783_Chip-Seq_NPCs_Mouse1.06597920
131AR_19668381_ChIP-Seq_PC3_Human1.06017541
132RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05955505
133TET1_21490601_ChIP-Seq_MESCs_Mouse1.05514836
134* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.02539679
135SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01299022
136TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01057558
137NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00771731
138TFEB_21752829_ChIP-Seq_HELA_Human1.00078339
139THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.99779167
140GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98625227
141ZNF274_21170338_ChIP-Seq_K562_Hela0.98242356
142ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.97886557
143TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97578957
144* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97490614
145SMAD4_21799915_ChIP-Seq_A2780_Human0.97457418
146MYC_18940864_ChIP-ChIP_HL60_Human0.97217212
147AR_21909140_ChIP-Seq_LNCAP_Human0.97083295
148PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96895133
149* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96314185
150CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95528998
151ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95421395
152CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95382461
153CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.93899981
154NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93875403
155* TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93669152
156HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.93299972
157CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93080862
158KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.92977985
159* FOXP1_21924763_ChIP-Seq_HESCs_Human0.92251792
160* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.92203395
161SOX2_21211035_ChIP-Seq_LN229_Gbm0.92171466
162TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.92047325
163SOX2_18555785_ChIP-Seq_MESCs_Mouse0.91941995
164TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90261679
165TET1_21451524_ChIP-Seq_MESCs_Mouse0.89471507
166YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89077937
167CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88893736
168OCT4_18692474_ChIP-Seq_MEFs_Mouse0.88727212
169SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.88248958
170* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87946164
171* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.87573427
172WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87446168
173SOX9_26525672_Chip-Seq_HEART_Mouse0.87308264
174EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.86798966
175PIAS1_25552417_ChIP-Seq_VCAP_Human0.86118362
176EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.84177520
177ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.83863188
178WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.83477039
179P300_19829295_ChIP-Seq_ESCs_Human0.83224072
180OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.81620871
181MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80622204
182SMAD3_21741376_ChIP-Seq_EPCs_Human0.80554006
183KDM2B_26808549_Chip-Seq_K562_Human0.80134663
184NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.78651737
185P53_22127205_ChIP-Seq_FIBROBLAST_Human0.78600999
186POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.77824329
187SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.77486025
188KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.77338279
189JUN_21703547_ChIP-Seq_K562_Human0.76438351
190TRIM28_21343339_ChIP-Seq_HEK293_Human0.76322891
191SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.75207875
192AR_25329375_ChIP-Seq_VCAP_Human0.74280140
193SMAD3_21741376_ChIP-Seq_ESCs_Human0.72834766
194STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.72551255
195SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.72527281

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.98177699
2MP0004859_abnormal_synaptic_plasticity4.74617423
3MP0001984_abnormal_olfaction4.17808505
4MP0003880_abnormal_central_pattern4.14009178
5MP0004270_analgesia3.76573942
6MP0003806_abnormal_nucleotide_metabolis3.56313502
7MP0004957_abnormal_blastocyst_morpholog3.35550958
8MP0005423_abnormal_somatic_nervous3.26545091
9MP0003635_abnormal_synaptic_transmissio3.09113572
10MP0006036_abnormal_mitochondrial_physio3.02995653
11MP0003283_abnormal_digestive_organ2.72278578
12MP0010094_abnormal_chromosome_stability2.70507208
13MP0006035_abnormal_mitochondrial_morpho2.58526952
14MP0002063_abnormal_learning/memory/cond2.57960201
15MP0002064_seizures2.57680039
16MP0008058_abnormal_DNA_repair2.54574973
17MP0009745_abnormal_behavioral_response2.51226822
18MP0002734_abnormal_mechanical_nocicepti2.42680054
19MP0009046_muscle_twitch2.41809049
20MP0002272_abnormal_nervous_system2.34630533
21MP0000778_abnormal_nervous_system2.33136138
22MP0002572_abnormal_emotion/affect_behav2.25098865
23MP0003122_maternal_imprinting2.24870888
24MP0003111_abnormal_nucleus_morphology2.24797211
25MP0003787_abnormal_imprinting2.19627639
26MP0003077_abnormal_cell_cycle2.18958855
27MP0001486_abnormal_startle_reflex2.17949436
28MP0002638_abnormal_pupillary_reflex2.14828030
29MP0002139_abnormal_hepatobiliary_system2.05688658
30MP0003123_paternal_imprinting2.01900057
31MP0001968_abnormal_touch/_nociception1.98820778
32MP0003195_calcinosis1.92864779
33MP0001764_abnormal_homeostasis1.81407532
34MP0002735_abnormal_chemical_nociception1.79228288
35MP0008875_abnormal_xenobiotic_pharmacok1.77211472
36MP0006072_abnormal_retinal_apoptosis1.75764897
37MP0003646_muscle_fatigue1.73885363
38MP0000955_abnormal_spinal_cord1.73540271
39MP0002736_abnormal_nociception_after1.71029886
40MP0002909_abnormal_adrenal_gland1.69878699
41MP0004811_abnormal_neuron_physiology1.67141209
42MP0002557_abnormal_social/conspecific_i1.65410152
43MP0001970_abnormal_pain_threshold1.61234184
44MP0005365_abnormal_bile_salt1.59767876
45MP0002837_dystrophic_cardiac_calcinosis1.59151838
46MP0008789_abnormal_olfactory_epithelium1.58353440
47MP0003329_amyloid_beta_deposits1.58100750
48MP0003186_abnormal_redox_activity1.57496253
49MP0000358_abnormal_cell_content/1.56259229
50MP0003718_maternal_effect1.55548670
51MP0002184_abnormal_innervation1.55393784
52MP0002067_abnormal_sensory_capabilities1.53906864
53MP0002733_abnormal_thermal_nociception1.52952338
54MP0002882_abnormal_neuron_morphology1.52184446
55MP0006276_abnormal_autonomic_nervous1.52150813
56MP0002653_abnormal_ependyma_morphology1.49113744
57MP0001502_abnormal_circadian_rhythm1.47378088
58MP0008569_lethality_at_weaning1.46631685
59MP0001188_hyperpigmentation1.45363367
60MP0006292_abnormal_olfactory_placode1.44504944
61MP0008932_abnormal_embryonic_tissue1.43358372
62MP0001730_embryonic_growth_arrest1.42097537
63MP0008007_abnormal_cellular_replicative1.37962374
64MP0004133_heterotaxia1.37225116
65MP0003315_abnormal_perineum_morphology1.36955196
66MP0001905_abnormal_dopamine_level1.35238423
67MP0005386_behavior/neurological_phenoty1.34303545
68MP0004924_abnormal_behavior1.34303545
69MP0004885_abnormal_endolymph1.34263984
70MP0002822_catalepsy1.33818345
71MP0002066_abnormal_motor_capabilities/c1.33548162
72MP0003879_abnormal_hair_cell1.32680009
73MP0004043_abnormal_pH_regulation1.32097543
74MP0000751_myopathy1.31696253
75MP0001986_abnormal_taste_sensitivity1.29925690
76MP0003121_genomic_imprinting1.29762736
77MP0001440_abnormal_grooming_behavior1.27992891
78MP0005266_abnormal_metabolism1.27979948
79MP0005360_urolithiasis1.26973880
80MP0002132_abnormal_respiratory_system1.25519997
81MP0002152_abnormal_brain_morphology1.24135099
82MP0005499_abnormal_olfactory_system1.23948933
83MP0005394_taste/olfaction_phenotype1.23948933
84MP0003786_premature_aging1.23040155
85MP0009780_abnormal_chondrocyte_physiolo1.20533230
86MP0005220_abnormal_exocrine_pancreas1.20477159
87MP0003656_abnormal_erythrocyte_physiolo1.20396778
88MP0001529_abnormal_vocalization1.18048834
89MP0010234_abnormal_vibrissa_follicle1.17926620
90MP0005085_abnormal_gallbladder_physiolo1.15344850
91MP0004215_abnormal_myocardial_fiber1.14460494
92MP0001501_abnormal_sleep_pattern1.13205898
93MP0001944_abnormal_pancreas_morphology1.12261330
94MP0000350_abnormal_cell_proliferation1.11567942
95MP0003763_abnormal_thymus_physiology1.10826388
96MP0005319_abnormal_enzyme/_coenzyme1.10670430
97MP0002019_abnormal_tumor_incidence1.10183398
98MP0008877_abnormal_DNA_methylation1.09115297
99MP0001299_abnormal_eye_distance/1.08279037
100MP0005636_abnormal_mineral_homeostasis1.07743103
101MP0005332_abnormal_amino_acid1.07442773
102MP0000490_abnormal_crypts_of1.07330060
103MP0002080_prenatal_lethality1.05683532
104MP0002752_abnormal_somatic_nervous1.05383820
105MP0005584_abnormal_enzyme/coenzyme_acti1.04508927
106MP0002396_abnormal_hematopoietic_system1.04360935
107MP0000313_abnormal_cell_death1.04212758
108MP0000013_abnormal_adipose_tissue1.03534938
109MP0003633_abnormal_nervous_system1.03296697
110MP0005075_abnormal_melanosome_morpholog1.02750757
111MP0004742_abnormal_vestibular_system1.01793732
112MP0002160_abnormal_reproductive_system1.00086044
113MP0005551_abnormal_eye_electrophysiolog0.99288381
114MP0003861_abnormal_nervous_system0.98811065
115MP0005187_abnormal_penis_morphology0.98785499
116MP0005084_abnormal_gallbladder_morpholo0.98459978
117MP0000566_synostosis0.98182339
118MP0002078_abnormal_glucose_homeostasis0.96245964
119MP0003631_nervous_system_phenotype0.96219762
120MP0009643_abnormal_urine_homeostasis0.96099092
121MP0001697_abnormal_embryo_size0.95382302
122MP0002229_neurodegeneration0.93727164
123MP0003221_abnormal_cardiomyocyte_apopto0.93028464
124MP0010386_abnormal_urinary_bladder0.91551105
125MP0000631_abnormal_neuroendocrine_gland0.90541565
126MP0009840_abnormal_foam_cell0.90157201
127MP0001485_abnormal_pinna_reflex0.89261882
128MP0001963_abnormal_hearing_physiology0.88182531
129MP0004233_abnormal_muscle_weight0.87799729
130MP0002693_abnormal_pancreas_physiology0.87689165
131MP0009333_abnormal_splenocyte_physiolog0.87020154
132MP0005646_abnormal_pituitary_gland0.87015172
133MP0000026_abnormal_inner_ear0.86994831
134MP0004145_abnormal_muscle_electrophysio0.86781467
135MP0002069_abnormal_eating/drinking_beha0.86107813
136MP0005645_abnormal_hypothalamus_physiol0.85404165
137MP0005623_abnormal_meninges_morphology0.85332804
138MP0002102_abnormal_ear_morphology0.85009547
139MP0003136_yellow_coat_color0.84989642
140MP0003866_abnormal_defecation0.84811821
141MP0008057_abnormal_DNA_replication0.84662212
142MP0005389_reproductive_system_phenotype0.82802994
143MP0000639_abnormal_adrenal_gland0.82455814
144MP0004142_abnormal_muscle_tone0.81788746
145MP0003634_abnormal_glial_cell0.81761946
146MP0001177_atelectasis0.81537743
147MP0009379_abnormal_foot_pigmentation0.81519503
148MP0002269_muscular_atrophy0.80352135
149MP0003137_abnormal_impulse_conducting0.79843216
150MP0003632_abnormal_nervous_system0.79005663
151MP0000049_abnormal_middle_ear0.78867916
152MP0005376_homeostasis/metabolism_phenot0.78235135
153MP0003938_abnormal_ear_development0.78078880
154MP0004147_increased_porphyrin_level0.76361592
155MP0002234_abnormal_pharynx_morphology0.75191509
156MP0000749_muscle_degeneration0.73968171
157MP0008260_abnormal_autophagy0.73945264
158MP0008872_abnormal_physiological_respon0.73897511
159MP0000598_abnormal_liver_morphology0.72154222
160MP0001666_abnormal_nutrient_absorption0.70541366
161MP0003953_abnormal_hormone_level0.69594738
162MP0000747_muscle_weakness0.69264886
163MP0004130_abnormal_muscle_cell0.68548617
164MP0004084_abnormal_cardiac_muscle0.68082274
165MP0000609_abnormal_liver_physiology0.67377695
166MP0002877_abnormal_melanocyte_morpholog0.66599949
167MP0000653_abnormal_sex_gland0.65451226
168MP0001145_abnormal_male_reproductive0.65128448
169MP0005253_abnormal_eye_physiology0.63252010
170MP0000750_abnormal_muscle_regeneration0.62754296
171MP0004085_abnormal_heartbeat0.62479304
172MP0001943_abnormal_respiration0.62183342
173MP0002249_abnormal_larynx_morphology0.61922413
174MP0003119_abnormal_digestive_system0.61491002
175MP0001346_abnormal_lacrimal_gland0.61219516
176MP0002081_perinatal_lethality0.60543612
177MP0010769_abnormal_survival0.60155281
178MP0000534_abnormal_ureter_morphology0.59344511

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.27096094
2Focal motor seizures (HP:0011153)4.75233593
3Decreased activity of mitochondrial respiratory chain (HP:0008972)4.74252267
4Abnormal activity of mitochondrial respiratory chain (HP:0011922)4.74252267
5Abnormal mitochondria in muscle tissue (HP:0008316)4.11857280
6Focal seizures (HP:0007359)4.07487729
7Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.02259335
8Abnormality of alanine metabolism (HP:0010916)4.02259335
9Hyperalaninemia (HP:0003348)4.02259335
10Acute necrotizing encephalopathy (HP:0006965)3.96619242
11Hepatic necrosis (HP:0002605)3.81975748
12Hepatocellular necrosis (HP:0001404)3.80841951
13Acute encephalopathy (HP:0006846)3.77258082
14Mitochondrial inheritance (HP:0001427)3.75415699
15Epileptic encephalopathy (HP:0200134)3.72702395
16Abnormality of cells of the erythroid lineage (HP:0012130)3.61350274
17Increased CSF lactate (HP:0002490)3.52273544
18Limb dystonia (HP:0002451)3.51302269
19Action tremor (HP:0002345)3.44545663
20Abnormal number of erythroid precursors (HP:0012131)3.40719011
21Aplastic anemia (HP:0001915)3.38672287
22Microretrognathia (HP:0000308)3.35165120
23Lactic acidosis (HP:0003128)3.31906603
24Increased serum lactate (HP:0002151)3.28326532
25Febrile seizures (HP:0002373)3.25033283
26Ankle clonus (HP:0011448)3.10958762
27Atonic seizures (HP:0010819)3.09158126
28Progressive macrocephaly (HP:0004481)3.05811875
29Polyphagia (HP:0002591)2.98940026
30Generalized tonic-clonic seizures (HP:0002069)2.84379389
31Progressive cerebellar ataxia (HP:0002073)2.83264855
32Palpitations (HP:0001962)2.82886524
33Abnormal eating behavior (HP:0100738)2.82280876
34Urinary urgency (HP:0000012)2.82047998
35Abnormality of aromatic amino acid family metabolism (HP:0004338)2.81698030
36Oral leukoplakia (HP:0002745)2.81511430
37Delayed CNS myelination (HP:0002188)2.81149171
38Spastic gait (HP:0002064)2.78660973
39Cerebral edema (HP:0002181)2.78035134
40Ragged-red muscle fibers (HP:0003200)2.75251386
41Increased intramyocellular lipid droplets (HP:0012240)2.74720068
42Abnormality of the corticospinal tract (HP:0002492)2.71757399
43Epileptiform EEG discharges (HP:0011182)2.70780803
44Birth length less than 3rd percentile (HP:0003561)2.70169369
45Absent rod-and cone-mediated responses on ERG (HP:0007688)2.63574430
46Reticulocytopenia (HP:0001896)2.63299596
47Increased muscle lipid content (HP:0009058)2.62504514
48Gait imbalance (HP:0002141)2.62249994
49Microvesicular hepatic steatosis (HP:0001414)2.61039594
50Exercise intolerance (HP:0003546)2.60841619
51Lipid accumulation in hepatocytes (HP:0006561)2.60256048
52Supranuclear gaze palsy (HP:0000605)2.59978167
53Hyperglycinemia (HP:0002154)2.58025119
54Colon cancer (HP:0003003)2.57515771
55EEG with generalized epileptiform discharges (HP:0011198)2.57488741
56Increased hepatocellular lipid droplets (HP:0006565)2.57460163
57Hypsarrhythmia (HP:0002521)2.55116850
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.48058925
59Urinary bladder sphincter dysfunction (HP:0002839)2.45952208
60Lethargy (HP:0001254)2.45772947
61Retinal dysplasia (HP:0007973)2.45053924
62Drooling (HP:0002307)2.44781546
63Impaired vibration sensation in the lower limbs (HP:0002166)2.44139248
64Poor suck (HP:0002033)2.43303025
65Fetal akinesia sequence (HP:0001989)2.40977724
66Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.39716978
67Posterior subcapsular cataract (HP:0007787)2.39101071
68Dialeptic seizures (HP:0011146)2.39013552
69Unsteady gait (HP:0002317)2.38667258
70Macrocytic anemia (HP:0001972)2.38002025
71Cerebral hypomyelination (HP:0006808)2.36046220
72Absence seizures (HP:0002121)2.35818361
73Abnormality of glycolysis (HP:0004366)2.34636157
74Increased serum pyruvate (HP:0003542)2.34636157
75Oligomenorrhea (HP:0000876)2.34624541
76Respiratory failure (HP:0002878)2.33466096
77Abnormality of the lower motor neuron (HP:0002366)2.32939773
78Generalized aminoaciduria (HP:0002909)2.31635637
79Emotional lability (HP:0000712)2.31382038
80Abnormality of serum amino acid levels (HP:0003112)2.31188574
81CNS demyelination (HP:0007305)2.30691733
82Hypobetalipoproteinemia (HP:0003563)2.29916007
83Degeneration of anterior horn cells (HP:0002398)2.29774072
84Abnormality of the anterior horn cell (HP:0006802)2.29774072
85Progressive muscle weakness (HP:0003323)2.28706531
86Amblyopia (HP:0000646)2.28688660
87Severe visual impairment (HP:0001141)2.26375866
88Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.25905830
89Akinesia (HP:0002304)2.24622325
90Myotonia (HP:0002486)2.24070996
91Sleep apnea (HP:0010535)2.22797206
92Breast hypoplasia (HP:0003187)2.22714825
93Neuroendocrine neoplasm (HP:0100634)2.22580191
94Degeneration of the lateral corticospinal tracts (HP:0002314)2.20996405
95Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.20996405
96Bony spicule pigmentary retinopathy (HP:0007737)2.19840626
97Dicarboxylic aciduria (HP:0003215)2.18374248
98Abnormality of dicarboxylic acid metabolism (HP:0010995)2.18374248
99Hypothermia (HP:0002045)2.16781486
100Congenital stationary night blindness (HP:0007642)2.16623672
101Broad-based gait (HP:0002136)2.16308027
102Torticollis (HP:0000473)2.15949085
103Type I transferrin isoform profile (HP:0003642)2.15201402
104Hypoglycemic coma (HP:0001325)2.15197314
105Excessive salivation (HP:0003781)2.14969814
106Spastic tetraplegia (HP:0002510)2.14491596
107Hyperglycinuria (HP:0003108)2.13850157
108Ependymoma (HP:0002888)2.12361338
109Hemiparesis (HP:0001269)2.12060679
110Ulnar claw (HP:0001178)2.11939394
111Status epilepticus (HP:0002133)2.11526573
112Abnormal rod and cone electroretinograms (HP:0008323)2.10187883
113Aplasia/Hypoplasia of the brainstem (HP:0007362)2.09595349
114Hypoplasia of the brainstem (HP:0002365)2.09595349
115Truncal ataxia (HP:0002078)2.07837738
116Pallor (HP:0000980)2.06958087
117Morphological abnormality of the pyramidal tract (HP:0002062)2.06850041
118Lower limb muscle weakness (HP:0007340)2.05924838
119Rough bone trabeculation (HP:0100670)2.04291441
120Adenoma sebaceum (HP:0009720)2.02301841
121Angiofibromas (HP:0010615)2.02301841
122Specific learning disability (HP:0001328)2.01608630
123Muscle fiber atrophy (HP:0100295)2.01373158
124Congenital primary aphakia (HP:0007707)1.99622517
125Depression (HP:0000716)1.99060501
126Abnormality of the heme biosynthetic pathway (HP:0010472)1.98204688
127Anxiety (HP:0000739)1.97302809
128Gout (HP:0001997)1.96269650
129Medial flaring of the eyebrow (HP:0010747)1.96204520
130Visual hallucinations (HP:0002367)1.96132885
131Multiple enchondromatosis (HP:0005701)1.95918663
132Late onset (HP:0003584)1.95012811
133Rhabdomyosarcoma (HP:0002859)1.91680508
1343-Methylglutaconic aciduria (HP:0003535)1.91326708
135Exercise-induced muscle cramps (HP:0003710)1.90718073
136Dysmetria (HP:0001310)1.90399666
137Amyotrophic lateral sclerosis (HP:0007354)1.90314873
138Type 2 muscle fiber atrophy (HP:0003554)1.90310255
139Diplopia (HP:0000651)1.90150513
140Abnormality of binocular vision (HP:0011514)1.90150513
141Lissencephaly (HP:0001339)1.90044680
142IgM deficiency (HP:0002850)1.89379493
143Abnormality of the labia minora (HP:0012880)1.88084026
144Hyperammonemia (HP:0001987)1.87626398
145Nephrogenic diabetes insipidus (HP:0009806)1.87261135
146Ketoacidosis (HP:0001993)1.86593037
147Hypoplasia of the corpus callosum (HP:0002079)1.86454055
148Poikiloderma (HP:0001029)1.86421727
149Nausea (HP:0002018)1.85978933
150CNS hypomyelination (HP:0003429)1.85179754
151Short tibia (HP:0005736)1.84871083
152Poor eye contact (HP:0000817)1.84254675
153Mutism (HP:0002300)1.83185883
154Neurofibrillary tangles (HP:0002185)1.82767172
155Focal dystonia (HP:0004373)1.82409889
156Split foot (HP:0001839)1.82296812
157Failure to thrive in infancy (HP:0001531)1.81967195
158Rimmed vacuoles (HP:0003805)1.81422372
159Hypoplasia of the pons (HP:0012110)1.81411470
160Postural instability (HP:0002172)1.81154089
161Abnormality of glycine metabolism (HP:0010895)1.81064153
162Abnormality of serine family amino acid metabolism (HP:0010894)1.81064153
163Chronic bronchitis (HP:0004469)1.80288809
164Cortical dysplasia (HP:0002539)1.79760359
165Hyperventilation (HP:0002883)1.79311680
166Optic disc pallor (HP:0000543)1.79186764
167Abnormality of fatty-acid metabolism (HP:0004359)1.78883649
168Delusions (HP:0000746)1.78695020
169Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.75639097
170Intention tremor (HP:0002080)1.75461717
171Ketosis (HP:0001946)1.72681884
172Incomplete penetrance (HP:0003829)1.72136202
173Pachygyria (HP:0001302)1.71913717
174Abnormal social behavior (HP:0012433)1.70937015
175Impaired social interactions (HP:0000735)1.70937015
176Vaginal atresia (HP:0000148)1.70853173
177Secondary amenorrhea (HP:0000869)1.69867950
178Dysdiadochokinesis (HP:0002075)1.69719032
179Genital tract atresia (HP:0001827)1.67895392
180Abnormal respiratory epithelium morphology (HP:0012253)1.66873574
181Abnormal respiratory motile cilium morphology (HP:0005938)1.66873574
182Peripheral hypomyelination (HP:0007182)1.66550679
183Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.66353553
184Insomnia (HP:0100785)1.65767964
185Agitation (HP:0000713)1.65245109
186Hand muscle atrophy (HP:0009130)1.63927439
187Spastic tetraparesis (HP:0001285)1.61394948
188Craniofacial dystonia (HP:0012179)1.60727365
189Absent speech (HP:0001344)1.59344323
190Esotropia (HP:0000565)1.57914417
191Hammertoe (HP:0001765)1.55254812
192Muscle fiber inclusion bodies (HP:0100299)1.54901681
193Clonus (HP:0002169)1.54656138
194Bradykinesia (HP:0002067)1.54544783

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPKAPK34.44166167
2STK164.19668133
3EPHA43.85366773
4EIF2AK13.52494547
5BUB13.23968561
6BCKDK3.22801688
7CASK3.18448809
8WEE12.94038810
9NME22.72588629
10NTRK32.65000449
11EEF2K2.64167463
12PAK62.63146725
13NTRK22.52849831
14MINK12.44262911
15MAP3K122.42889361
16MAP3K42.39367673
17MAP2K72.33634497
18ACVR1B2.30893246
19EIF2AK32.20676035
20FLT32.18337986
21RPS6KB22.15465649
22ARAF2.14385785
23DAPK12.13767076
24UHMK11.98981152
25DYRK31.96998634
26PASK1.92104118
27BRAF1.85593017
28BCR1.83272406
29NEK11.83022715
30PINK11.81751762
31LIMK11.78398277
32NTRK11.71780150
33VRK11.69426798
34SRPK11.62714368
35TLK11.60326706
36SCYL21.57336655
37MAP2K41.54412001
38CDC71.50634600
39PAK31.45898410
40SIK21.43298451
41PRKCG1.41794051
42PIM21.40806432
43CDK51.39445259
44CAMKK11.39001182
45TAOK31.37072937
46TSSK61.35764802
47BRSK21.34672884
48TESK11.31926072
49NEK21.30167306
50AURKA1.29499559
51CDK81.28656661
52PLK11.28092705
53PRKD31.27835759
54DYRK21.26089600
55PLK21.20597799
56CSNK1A1L1.19829603
57TTK1.17722572
58LATS21.17655625
59MUSK1.14953328
60TRIM281.14780471
61CAMK2B1.13172331
62CCNB11.12728218
63OBSCN1.12663294
64CDK141.12288599
65NME11.09387221
66CDK181.08404613
67CDK151.06789296
68AURKB1.06354888
69CAMK2A1.06272647
70BRSK11.04613888
71PNCK1.03401167
72MAP3K111.02083269
73CDK11A1.00868487
74CDK191.00705438
75SGK2230.99235755
76SGK4940.99235755
77RAF10.98365883
78DYRK1A0.98330244
79CAMK10.94899012
80TYRO30.92841638
81KDR0.92529882
82CAMK2G0.92490784
83KSR10.92056718
84TGFBR10.90214773
85CDK70.87803213
86MAP3K90.87262424
87PKN10.84662425
88PLK40.84474390
89GRK50.81349096
90CSNK1G30.81289101
91MAP3K130.80810422
92TESK20.78367067
93PRKCI0.76993213
94TEC0.75850503
95ATR0.74234560
96DAPK20.73912522
97MARK20.71659709
98PKN20.71237940
99DAPK30.68464080
100MAP4K20.67491791
101OXSR10.66370144
102PHKG20.65991597
103PHKG10.65991597
104AKT20.64586744
105CAMK2D0.62274276
106PRKCZ0.61794916
107MAPK110.61590932
108CSNK2A20.61290585
109ILK0.58300996
110CAMK40.57690039
111CHEK20.57335843
112CAMKK20.55097394
113EPHB20.54780552
114CSNK2A10.54404318
115CSNK1E0.54246301
116PRKCE0.53535784
117TNK20.52607586
118LMTK20.52535465
119PAK40.51556291
120MOS0.51464784
121STK110.51055872
122PRKCH0.50581165
123RPS6KA40.49904948
124PRKAA10.49728131
125CSNK1G10.48569105
126GRK60.46969026
127CSNK1G20.45900924
128EPHA20.45073572
129ERBB30.44373135
130ICK0.43497889
131MAPK100.42964376
132RPS6KA30.42861055
133MAP3K80.42201717
134WNK40.42031868
135PRKACA0.41503636
136SGK10.41052185
137DYRK1B0.39421102
138EPHA30.38928178
139PIK3CA0.38528671
140MAPK130.38250546
141SGK20.38230320
142PLK30.38173290
143STK380.38171937
144MYLK0.37912135
145PDK30.37865209
146PDK40.37865209
147MAPKAPK50.37765886
148WNK30.37498599
149CSNK1D0.37089148
150MAPK120.36997114
151CAMK1G0.36376629
152LRRK20.36307197
153CSNK1A10.35993203
154KSR20.35175266
155ADRBK20.32994503
156MAPK150.32267875
157MAP2K60.31760938
158NEK60.30987276
159DMPK0.30834567
160KIT0.30580220
161MAP4K10.29530121
162TAOK10.28800045
163MAP2K20.27622264
164CHEK10.25549192
165ZAP700.25047391
166ERN10.24511136
167CDK20.24278750
168PAK10.23808160
169CDK40.23477545
170MARK10.22465740
171RPS6KB10.21307761

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.01809964
2Nicotine addiction_Homo sapiens_hsa050333.83496282
3DNA replication_Homo sapiens_hsa030303.30920054
4Proteasome_Homo sapiens_hsa030503.26448876
5RNA polymerase_Homo sapiens_hsa030203.01561134
6Mismatch repair_Homo sapiens_hsa034302.90161994
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.76359205
8Parkinsons disease_Homo sapiens_hsa050122.66058972
9Sulfur relay system_Homo sapiens_hsa041222.61368766
10Oxidative phosphorylation_Homo sapiens_hsa001902.56540264
11GABAergic synapse_Homo sapiens_hsa047272.55048639
12Pyrimidine metabolism_Homo sapiens_hsa002402.49766664
13Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.39225897
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.35202247
15Spliceosome_Homo sapiens_hsa030402.23625119
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.22360120
17Circadian entrainment_Homo sapiens_hsa047132.19903480
18Folate biosynthesis_Homo sapiens_hsa007902.19177055
19Protein export_Homo sapiens_hsa030602.14980132
20Morphine addiction_Homo sapiens_hsa050322.10250541
21Amphetamine addiction_Homo sapiens_hsa050312.10067814
22Glutamatergic synapse_Homo sapiens_hsa047242.08299536
23Dopaminergic synapse_Homo sapiens_hsa047282.06693386
24RNA transport_Homo sapiens_hsa030132.00541915
25Nucleotide excision repair_Homo sapiens_hsa034201.97103050
26Base excision repair_Homo sapiens_hsa034101.96839858
27Cocaine addiction_Homo sapiens_hsa050301.91938897
28Huntingtons disease_Homo sapiens_hsa050161.80986595
292-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.76538210
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.73204538
31Homologous recombination_Homo sapiens_hsa034401.68140615
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.65500150
33Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.63588575
34Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.63245455
35Long-term potentiation_Homo sapiens_hsa047201.62925065
36Maturity onset diabetes of the young_Homo sapiens_hsa049501.59490251
37Phototransduction_Homo sapiens_hsa047441.58945399
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.53514273
39Purine metabolism_Homo sapiens_hsa002301.53367341
40Alzheimers disease_Homo sapiens_hsa050101.53057868
41Cysteine and methionine metabolism_Homo sapiens_hsa002701.52104899
42Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50555572
43RNA degradation_Homo sapiens_hsa030181.49704524
44Carbon metabolism_Homo sapiens_hsa012001.47174119
45Gastric acid secretion_Homo sapiens_hsa049711.46428499
46One carbon pool by folate_Homo sapiens_hsa006701.45421864
47Biosynthesis of amino acids_Homo sapiens_hsa012301.40767289
48Cholinergic synapse_Homo sapiens_hsa047251.40630470
49Olfactory transduction_Homo sapiens_hsa047401.40313804
50Axon guidance_Homo sapiens_hsa043601.39864647
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39648613
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.34734680
53Collecting duct acid secretion_Homo sapiens_hsa049661.32165533
54Aldosterone synthesis and secretion_Homo sapiens_hsa049251.31743960
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.27068517
56Pentose phosphate pathway_Homo sapiens_hsa000301.26093062
57Cell cycle_Homo sapiens_hsa041101.25528783
58Salivary secretion_Homo sapiens_hsa049701.22237204
59Fructose and mannose metabolism_Homo sapiens_hsa000511.21895078
60Oxytocin signaling pathway_Homo sapiens_hsa049211.20960417
61Taste transduction_Homo sapiens_hsa047421.20539115
62Pyruvate metabolism_Homo sapiens_hsa006201.16704716
63Calcium signaling pathway_Homo sapiens_hsa040201.11141759
64Long-term depression_Homo sapiens_hsa047301.08965458
65Gap junction_Homo sapiens_hsa045401.08407780
66Basal transcription factors_Homo sapiens_hsa030221.07675518
67Cyanoamino acid metabolism_Homo sapiens_hsa004601.05540512
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.04950539
69Selenocompound metabolism_Homo sapiens_hsa004501.04874827
70Sulfur metabolism_Homo sapiens_hsa009201.04594362
71cAMP signaling pathway_Homo sapiens_hsa040241.03720005
72Dilated cardiomyopathy_Homo sapiens_hsa054141.03520707
73Galactose metabolism_Homo sapiens_hsa000521.02932066
74Serotonergic synapse_Homo sapiens_hsa047260.98987924
75Renin secretion_Homo sapiens_hsa049240.98177322
76Cardiac muscle contraction_Homo sapiens_hsa042600.95990451
77Propanoate metabolism_Homo sapiens_hsa006400.95054866
78Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.94003280
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.92391567
80Melanogenesis_Homo sapiens_hsa049160.90794547
81Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90664813
82Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.90615964
83Non-homologous end-joining_Homo sapiens_hsa034500.87359387
84N-Glycan biosynthesis_Homo sapiens_hsa005100.86460173
85Hippo signaling pathway_Homo sapiens_hsa043900.85150811
86Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84530413
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.83758627
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.82581912
89Fanconi anemia pathway_Homo sapiens_hsa034600.80835180
90Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80722050
91Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78083117
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.77250454
93Metabolic pathways_Homo sapiens_hsa011000.74958362
94Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.73892920
95Peroxisome_Homo sapiens_hsa041460.73705496
96Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70818795
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.70712358
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.69712004
99cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68167261
100GnRH signaling pathway_Homo sapiens_hsa049120.67832214
101Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.66458944
102Estrogen signaling pathway_Homo sapiens_hsa049150.65797470
103mRNA surveillance pathway_Homo sapiens_hsa030150.64060737
104Other glycan degradation_Homo sapiens_hsa005110.63453483
105Fatty acid degradation_Homo sapiens_hsa000710.62850280
106Tight junction_Homo sapiens_hsa045300.62654211
107Systemic lupus erythematosus_Homo sapiens_hsa053220.62597995
108Alcoholism_Homo sapiens_hsa050340.62473284
109Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62283774
110AMPK signaling pathway_Homo sapiens_hsa041520.62033672
111Regulation of autophagy_Homo sapiens_hsa041400.61969592
112Steroid biosynthesis_Homo sapiens_hsa001000.61025877
113Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59741988
114ErbB signaling pathway_Homo sapiens_hsa040120.56959146
115p53 signaling pathway_Homo sapiens_hsa041150.55149133
116beta-Alanine metabolism_Homo sapiens_hsa004100.54914206
117Oocyte meiosis_Homo sapiens_hsa041140.52441846
118Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51222708
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.51221474
120Thyroid hormone synthesis_Homo sapiens_hsa049180.50909864
121Type II diabetes mellitus_Homo sapiens_hsa049300.50172426
122Bile secretion_Homo sapiens_hsa049760.49691871
123Vitamin B6 metabolism_Homo sapiens_hsa007500.49614528
124Hedgehog signaling pathway_Homo sapiens_hsa043400.48817159
125Wnt signaling pathway_Homo sapiens_hsa043100.48044277
126Arginine and proline metabolism_Homo sapiens_hsa003300.46146790
127Butanoate metabolism_Homo sapiens_hsa006500.45929515
128Primary bile acid biosynthesis_Homo sapiens_hsa001200.45896727
129Glioma_Homo sapiens_hsa052140.45606970
130Ras signaling pathway_Homo sapiens_hsa040140.43630078
131Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.43604433
132Histidine metabolism_Homo sapiens_hsa003400.43567772
133Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43181745
134Epstein-Barr virus infection_Homo sapiens_hsa051690.42282604
135Pancreatic secretion_Homo sapiens_hsa049720.40714548
136Thyroid cancer_Homo sapiens_hsa052160.38814505
137Pentose and glucuronate interconversions_Homo sapiens_hsa000400.37450552
138Rap1 signaling pathway_Homo sapiens_hsa040150.36888731
139Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.36876523
140Phosphatidylinositol signaling system_Homo sapiens_hsa040700.36808743
141Thyroid hormone signaling pathway_Homo sapiens_hsa049190.36594423
142Basal cell carcinoma_Homo sapiens_hsa052170.36492608
143Glutathione metabolism_Homo sapiens_hsa004800.36283394
144Synaptic vesicle cycle_Homo sapiens_hsa047210.36220449
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.34907704
146SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32697710
147Arginine biosynthesis_Homo sapiens_hsa002200.32436680
148Caffeine metabolism_Homo sapiens_hsa002320.31816644
149Vibrio cholerae infection_Homo sapiens_hsa051100.29119219
150Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.27198251
151Circadian rhythm_Homo sapiens_hsa047100.26291998
152Tryptophan metabolism_Homo sapiens_hsa003800.25929782
153Antigen processing and presentation_Homo sapiens_hsa046120.22931695
154Phenylalanine metabolism_Homo sapiens_hsa003600.20480527
155Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.19622116
156Insulin secretion_Homo sapiens_hsa049110.17538703
157Starch and sucrose metabolism_Homo sapiens_hsa005000.17317992
158Glucagon signaling pathway_Homo sapiens_hsa049220.16462012
159Tyrosine metabolism_Homo sapiens_hsa003500.14813116
160Insulin signaling pathway_Homo sapiens_hsa049100.14453468
161Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.13363570
162Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.11213821

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