NHEJ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit assembly (GO:0000028)5.02122931
2DNA double-strand break processing (GO:0000729)4.86008436
3DNA replication checkpoint (GO:0000076)4.60325999
4CENP-A containing nucleosome assembly (GO:0034080)4.47057197
5kinetochore organization (GO:0051383)4.40904811
6proteasome assembly (GO:0043248)4.39459806
7kinetochore assembly (GO:0051382)4.31068827
8mitotic metaphase plate congression (GO:0007080)4.26048551
9chromatin remodeling at centromere (GO:0031055)4.24693827
10attachment of spindle microtubules to kinetochore (GO:0008608)4.21549815
11maturation of SSU-rRNA (GO:0030490)4.19906347
12protein localization to kinetochore (GO:0034501)4.19138039
13DNA strand elongation involved in DNA replication (GO:0006271)4.10060162
14telomere maintenance via semi-conservative replication (GO:0032201)4.08230022
15protein neddylation (GO:0045116)3.93562453
16telomere maintenance via recombination (GO:0000722)3.91632586
17DNA strand elongation (GO:0022616)3.90722599
18somatic diversification of immune receptors via somatic mutation (GO:0002566)3.84076502
19somatic hypermutation of immunoglobulin genes (GO:0016446)3.84076502
20cullin deneddylation (GO:0010388)3.83930084
21protein localization to chromosome, centromeric region (GO:0071459)3.82423474
22DNA replication-independent nucleosome assembly (GO:0006336)3.81821563
23DNA replication-independent nucleosome organization (GO:0034724)3.81821563
24mitotic sister chromatid segregation (GO:0000070)3.77311670
25DNA catabolic process, exonucleolytic (GO:0000738)3.76439955
26mitotic nuclear envelope disassembly (GO:0007077)3.75539453
27purine nucleobase biosynthetic process (GO:0009113)3.72556986
28protein deneddylation (GO:0000338)3.72221201
29DNA replication initiation (GO:0006270)3.69173370
30nucleobase biosynthetic process (GO:0046112)3.66808734
31establishment of integrated proviral latency (GO:0075713)3.65035725
32formation of translation preinitiation complex (GO:0001731)3.63674936
33histone exchange (GO:0043486)3.63111788
34metaphase plate congression (GO:0051310)3.62561761
35mitotic recombination (GO:0006312)3.58946015
36regulation of spindle organization (GO:0090224)3.58440328
37DNA deamination (GO:0045006)3.57736761
38mitotic chromosome condensation (GO:0007076)3.51008116
39regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.50877281
40establishment of chromosome localization (GO:0051303)3.48112722
41nuclear envelope disassembly (GO:0051081)3.47009850
42membrane disassembly (GO:0030397)3.47009850
43ribosomal small subunit biogenesis (GO:0042274)3.46916559
44oxidative phosphorylation (GO:0006119)3.46330159
45viral transcription (GO:0019083)3.44747708
46translational termination (GO:0006415)3.41140557
47DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.40000189
48signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.39804921
49signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.39804921
50signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.39804921
51lactate metabolic process (GO:0006089)3.37521354
52regulation of cellular amino acid metabolic process (GO:0006521)3.37121099
53establishment of protein localization to mitochondrial membrane (GO:0090151)3.35430729
54intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.35388192
55signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.35388192
56exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.34254001
57nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.32569103
58peptidyl-histidine modification (GO:0018202)3.30962544
59signal transduction involved in cell cycle checkpoint (GO:0072395)3.30321583
60ribonucleoprotein complex biogenesis (GO:0022613)3.28918862
61anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.28911405
62signal transduction involved in DNA integrity checkpoint (GO:0072401)3.28446704
63signal transduction involved in DNA damage checkpoint (GO:0072422)3.28446704
64GTP biosynthetic process (GO:0006183)3.28246327
65ribosome biogenesis (GO:0042254)3.27799625
66telomere maintenance via telomere lengthening (GO:0010833)3.26406518
67DNA damage response, detection of DNA damage (GO:0042769)3.24855255
68chaperone-mediated protein transport (GO:0072321)3.23596977
69CTP biosynthetic process (GO:0006241)3.22767586
70CTP metabolic process (GO:0046036)3.22767586
71deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.22619595
72positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.21216895
73ribosomal large subunit biogenesis (GO:0042273)3.20362091
74SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.18619227
75protein K6-linked ubiquitination (GO:0085020)3.18186748
76* non-recombinational repair (GO:0000726)3.18043331
77* double-strand break repair via nonhomologous end joining (GO:0006303)3.18043331
78regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.16917129
79translational initiation (GO:0006413)3.16899809
80sister chromatid segregation (GO:0000819)3.16639289
81spindle checkpoint (GO:0031577)3.15333884
82negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.14869107
83ribosome assembly (GO:0042255)3.14738488
84synapsis (GO:0007129)3.14436193
85rRNA methylation (GO:0031167)3.14366452
86rRNA modification (GO:0000154)3.14220683
87pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.14170375
88tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.13687175
89RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.13687175
90cotranslational protein targeting to membrane (GO:0006613)3.10724970
91* positive regulation of ligase activity (GO:0051351)3.10443363
92mitochondrial RNA metabolic process (GO:0000959)3.10122815
93regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.09957587
94IMP biosynthetic process (GO:0006188)3.09765299
95translational elongation (GO:0006414)3.09579147
96regulation of mitochondrial translation (GO:0070129)3.09053036
97protein targeting to ER (GO:0045047)3.08210788
98somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.07356040
99somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.07356040
100isotype switching (GO:0045190)3.07356040
101respiratory chain complex IV assembly (GO:0008535)3.05323133
102regulation of double-strand break repair via homologous recombination (GO:0010569)3.04810990
103mitochondrial respiratory chain complex assembly (GO:0033108)3.04339897
104nucleotide-excision repair, DNA gap filling (GO:0006297)3.04251574
105pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.04250047
106protein targeting to mitochondrion (GO:0006626)3.03861260
107pseudouridine synthesis (GO:0001522)3.03825297
108negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.03708041
109negative regulation of sister chromatid segregation (GO:0033046)3.03708041
110negative regulation of mitotic sister chromatid separation (GO:2000816)3.03708041
111negative regulation of mitotic sister chromatid segregation (GO:0033048)3.03708041
112meiotic chromosome segregation (GO:0045132)3.02696330
113amino acid activation (GO:0043038)3.02608985
114tRNA aminoacylation (GO:0043039)3.02608985
115positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.02202014
116UTP biosynthetic process (GO:0006228)3.02185216
117negative regulation of chromosome segregation (GO:0051985)3.01826286
118tRNA aminoacylation for protein translation (GO:0006418)3.01371281
119protein complex biogenesis (GO:0070271)3.00924906
120spindle assembly checkpoint (GO:0071173)3.00342799
121pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.99727971
122negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.99686661
123chromosome segregation (GO:0007059)2.97858947
124regulation of chromosome segregation (GO:0051983)2.97787726
125regulation of mitotic metaphase/anaphase transition (GO:0030071)2.97624377
126protein localization to endoplasmic reticulum (GO:0070972)2.94976653
127rRNA processing (GO:0006364)2.94874463
128regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.94655212
129mitotic spindle assembly checkpoint (GO:0007094)2.94287316
130pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.93543564
131regulation of mitotic spindle organization (GO:0060236)2.91953846
132mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.91131589
133regulation of ubiquitin-protein transferase activity (GO:0051438)2.91032613
134guanosine-containing compound biosynthetic process (GO:1901070)2.90282576
135establishment of protein localization to endoplasmic reticulum (GO:0072599)2.88593917
136G1/S transition of mitotic cell cycle (GO:0000082)2.87815641
137cell cycle G1/S phase transition (GO:0044843)2.87815641
138UTP metabolic process (GO:0046051)2.87802477
139IMP metabolic process (GO:0046040)2.86498593
140rRNA metabolic process (GO:0016072)2.85760756
141tRNA metabolic process (GO:0006399)2.84736947
142mitotic spindle checkpoint (GO:0071174)2.84143941
143regulation of translation in response to stress (GO:0043555)2.83943888
144* regulation of ligase activity (GO:0051340)2.83024305
145cytochrome complex assembly (GO:0017004)2.82162234
146folic acid-containing compound biosynthetic process (GO:0009396)2.81836202
147negative regulation of ligase activity (GO:0051352)2.81566198
148negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.81566198
149replication fork processing (GO:0031297)2.80944643
150spliceosomal snRNP assembly (GO:0000387)2.78609062
151nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.78592980
152regulation of mitotic sister chromatid separation (GO:0010965)2.76118638
153regulation of mitotic sister chromatid segregation (GO:0033047)2.76118638
154regulation of sister chromatid segregation (GO:0033045)2.76118638
155DNA replication-dependent nucleosome organization (GO:0034723)2.75859158
156DNA replication-dependent nucleosome assembly (GO:0006335)2.75859158
157translation (GO:0006412)2.75843004
158maturation of 5.8S rRNA (GO:0000460)2.75569404
159positive regulation of chromosome segregation (GO:0051984)2.75410973
160regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.72353975
161regulation of mitotic spindle checkpoint (GO:1903504)2.72353975
162notochord development (GO:0030903)2.72272553
163transcription-coupled nucleotide-excision repair (GO:0006283)2.71479470

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.07169350
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.05464218
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.96111296
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.54831566
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.51662758
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.50072515
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.45097590
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.06784541
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.96382094
10CREB1_15753290_ChIP-ChIP_HEK293T_Human2.90315147
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.80133002
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.72713958
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69061023
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.64491354
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.62328575
16AR_21909140_ChIP-Seq_LNCAP_Human2.43779479
17* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30441491
18VDR_23849224_ChIP-Seq_CD4+_Human2.26936206
19MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.25068664
20XRN2_22483619_ChIP-Seq_HELA_Human2.21858855
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.21416526
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.11305113
23DCP1A_22483619_ChIP-Seq_HELA_Human2.02736187
24ELF1_17652178_ChIP-ChIP_JURKAT_Human1.99151715
25* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.98887234
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.98732657
27SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.97540620
28HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.93068616
29MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.83592092
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82852886
31FOXP3_21729870_ChIP-Seq_TREG_Human1.78730618
32TTF2_22483619_ChIP-Seq_HELA_Human1.74990651
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.74106503
34GABP_19822575_ChIP-Seq_HepG2_Human1.72184676
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.66646046
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.65451606
37SRF_21415370_ChIP-Seq_HL-1_Mouse1.63514375
38HOXB4_20404135_ChIP-ChIP_EML_Mouse1.62082943
39ELK1_19687146_ChIP-ChIP_HELA_Human1.56568462
40EGR1_19374776_ChIP-ChIP_THP-1_Human1.56537472
41FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.54028150
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.52214044
43THAP11_20581084_ChIP-Seq_MESCs_Mouse1.49837050
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47405103
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.46429240
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.42401833
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41563084
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.41303188
49SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.40712752
50ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.39757243
51ZNF274_21170338_ChIP-Seq_K562_Hela1.39360018
52SALL1_21062744_ChIP-ChIP_HESCs_Human1.39358066
53IRF1_19129219_ChIP-ChIP_H3396_Human1.39162632
54KDM5A_27292631_Chip-Seq_BREAST_Human1.36360379
55* FLI1_27457419_Chip-Seq_LIVER_Mouse1.35659502
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.34018955
57SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.30871538
58YY1_21170310_ChIP-Seq_MESCs_Mouse1.29517713
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29306383
60SPI1_23547873_ChIP-Seq_NB4_Human1.28636920
61VDR_22108803_ChIP-Seq_LS180_Human1.24835872
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23995020
63* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.23503783
64YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23261584
65HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.23244832
66IRF8_21731497_ChIP-ChIP_J774_Mouse1.21587044
67PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21019364
68KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19561972
69ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19455186
70ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18602348
71CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.17325159
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.16859178
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.16829220
74MYC_22102868_ChIP-Seq_BL_Human1.15065012
75E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13607735
76STAT3_1855785_ChIP-Seq_MESCs_Mouse1.12844322
77CIITA_25753668_ChIP-Seq_RAJI_Human1.11740217
78IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.09050409
79MYB_21317192_ChIP-Seq_ERMYB_Mouse1.07458337
80* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07087954
81DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01511870
82ELK1_22589737_ChIP-Seq_MCF10A_Human1.01271269
83* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.99422856
84RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98817881
85TFEB_21752829_ChIP-Seq_HELA_Human0.98712320
86MYC_18940864_ChIP-ChIP_HL60_Human0.98646206
87POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98594117
88TP63_19390658_ChIP-ChIP_HaCaT_Human0.97866742
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.97523581
90EWS_26573619_Chip-Seq_HEK293_Human0.95958080
91ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.95121464
92PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93658263
93CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.91662745
94* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.91398735
95CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90763904
96NANOG_16153702_ChIP-ChIP_HESCs_Human0.90733145
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.90150556
98NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.89328846
99BP1_19119308_ChIP-ChIP_Hs578T_Human0.88895431
100GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.87926740
101POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87926039
102MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.86649033
103SOX17_20123909_ChIP-Seq_XEN_Mouse0.85489702
104IRF8_22096565_ChIP-ChIP_GC-B_Human0.84747266
105SOX2_16153702_ChIP-ChIP_HESCs_Human0.84346747
106DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.83443493
107VDR_21846776_ChIP-Seq_THP-1_Human0.82213505
108SOX2_18555785_ChIP-Seq_MESCs_Mouse0.81088138
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.79660286
110CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.77444082
111FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76335639
112CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.75455677
113TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.74568811
114KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.73419902
115* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.72729045
116STAT4_19710469_ChIP-ChIP_TH1__Mouse0.72529186
117MYB_26560356_Chip-Seq_TH1_Human0.72442750
118IGF1R_20145208_ChIP-Seq_DFB_Human0.71860034
119* PCGF2_27294783_Chip-Seq_NPCs_Mouse0.67996142
120POU5F1_16153702_ChIP-ChIP_HESCs_Human0.67236376
121* NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.63069262
122CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.62368186

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.92611147
2* MP0010094_abnormal_chromosome_stability4.19783193
3MP0004957_abnormal_blastocyst_morpholog3.66466270
4MP0003111_abnormal_nucleus_morphology3.46867365
5MP0003077_abnormal_cell_cycle3.46712779
6MP0003646_muscle_fatigue3.26038947
7MP0000372_irregular_coat_pigmentation3.08838120
8MP0008007_abnormal_cellular_replicative2.77783255
9MP0008057_abnormal_DNA_replication2.72330533
10MP0002396_abnormal_hematopoietic_system2.38378484
11MP0003718_maternal_effect2.36162767
12MP0002102_abnormal_ear_morphology2.31948921
13* MP0008058_abnormal_DNA_repair2.26171567
14MP0005075_abnormal_melanosome_morpholog2.19397349
15MP0003436_decreased_susceptibility_to2.05035064
16MP0008932_abnormal_embryonic_tissue2.00489128
17MP0003123_paternal_imprinting1.97186644
18MP0008877_abnormal_DNA_methylation1.93716370
19MP0003656_abnormal_erythrocyte_physiolo1.90884481
20MP0003806_abnormal_nucleotide_metabolis1.90241488
21MP0003186_abnormal_redox_activity1.86634803
22MP0001853_heart_inflammation1.84583686
23MP0010307_abnormal_tumor_latency1.79196460
24MP0000350_abnormal_cell_proliferation1.78640109
25MP0003786_premature_aging1.78153867
26MP0006035_abnormal_mitochondrial_morpho1.77802427
27MP0002938_white_spotting1.76158718
28MP0006072_abnormal_retinal_apoptosis1.76012895
29MP0001730_embryonic_growth_arrest1.70671080
30MP0002933_joint_inflammation1.69187278
31MP0004147_increased_porphyrin_level1.65193770
32MP0009333_abnormal_splenocyte_physiolog1.63153528
33MP0010030_abnormal_orbit_morphology1.59434619
34MP0005408_hypopigmentation1.55376879
35MP0001293_anophthalmia1.54939535
36MP0001545_abnormal_hematopoietic_system1.48102371
37MP0005397_hematopoietic_system_phenotyp1.48102371
38MP0000015_abnormal_ear_pigmentation1.47178837
39MP0004808_abnormal_hematopoietic_stem1.42164711
40MP0000490_abnormal_crypts_of1.41400507
41MP0005084_abnormal_gallbladder_morpholo1.40394503
42MP0001835_abnormal_antigen_presentation1.39297355
43* MP0002019_abnormal_tumor_incidence1.37439184
44MP0010352_gastrointestinal_tract_polyps1.37209776
45MP0002837_dystrophic_cardiac_calcinosis1.37144370
46MP0003890_abnormal_embryonic-extraembry1.35604460
47MP0005171_absent_coat_pigmentation1.35013035
48MP0008789_abnormal_olfactory_epithelium1.31586238
49MP0002210_abnormal_sex_determination1.30431260
50MP0003763_abnormal_thymus_physiology1.29037627
51MP0002751_abnormal_autonomic_nervous1.27975958
52MP0003195_calcinosis1.27681523
53MP0001533_abnormal_skeleton_physiology1.27335202
54MP0001672_abnormal_embryogenesis/_devel1.24698636
55MP0005380_embryogenesis_phenotype1.24698636
56MP0005083_abnormal_biliary_tract1.20945165
57MP0005410_abnormal_fertilization1.19936401
58* MP0000689_abnormal_spleen_morphology1.19512651
59* MP0002398_abnormal_bone_marrow1.18618039
60MP0002282_abnormal_trachea_morphology1.17968032
61MP0009785_altered_susceptibility_to1.17310654
62MP0002254_reproductive_system_inflammat1.16927947
63MP0002234_abnormal_pharynx_morphology1.16435391
64* MP0000313_abnormal_cell_death1.16222848
65MP0003567_abnormal_fetal_cardiomyocyte1.16122987
66MP0003724_increased_susceptibility_to1.15490090
67MP0001697_abnormal_embryo_size1.14209564
68MP0003984_embryonic_growth_retardation1.13718697
69MP0002160_abnormal_reproductive_system1.12946282
70* MP0002722_abnormal_immune_system1.12335358
71MP0002088_abnormal_embryonic_growth/wei1.10266050
72MP0001119_abnormal_female_reproductive1.10147817
73MP0003698_abnormal_male_reproductive1.09603127
74MP0002132_abnormal_respiratory_system1.09099067
75MP0008995_early_reproductive_senescence1.08544856
76MP0001542_abnormal_bone_strength1.06747113
77MP0005670_abnormal_white_adipose1.06653144
78* MP0001800_abnormal_humoral_immune1.06505651
79MP0009379_abnormal_foot_pigmentation1.06368353
80MP0000858_altered_metastatic_potential1.04425847
81* MP0002452_abnormal_antigen_presenting1.04267697
82MP0002095_abnormal_skin_pigmentation1.03681746
83MP0001929_abnormal_gametogenesis1.02492077
84MP0005451_abnormal_body_composition1.01980057
85MP0003941_abnormal_skin_development1.01547921
86MP0001145_abnormal_male_reproductive1.00944070
87MP0005000_abnormal_immune_tolerance1.00941138
88MP0005365_abnormal_bile_salt1.00771749
89* MP0002429_abnormal_blood_cell1.00477948
90MP0002080_prenatal_lethality0.99143182
91MP0001324_abnormal_eye_pigmentation0.99133792
92MP0003121_genomic_imprinting0.98994810
93MP0002419_abnormal_innate_immunity0.97329794
94* MP0002420_abnormal_adaptive_immunity0.94327107
95MP0002148_abnormal_hypersensitivity_rea0.94085154
96* MP0000716_abnormal_immune_system0.93926483
97* MP0001819_abnormal_immune_cell0.93896340
98MP0005253_abnormal_eye_physiology0.93728200
99MP0005390_skeleton_phenotype0.93673940
100MP0002405_respiratory_system_inflammati0.92709542
101* MP0000703_abnormal_thymus_morphology0.92043333
102MP0005025_abnormal_response_to0.91465314
103MP0000653_abnormal_sex_gland0.91392566
104* MP0002723_abnormal_immune_serum0.91044796
105MP0003011_delayed_dark_adaptation0.90289182
106MP0004134_abnormal_chest_morphology0.90209477
107MP0004197_abnormal_fetal_growth/weight/0.89898382
108MP0009697_abnormal_copulation0.89623948
109MP0003303_peritoneal_inflammation0.85837891
110MP0001661_extended_life_span0.85772891
111MP0000163_abnormal_cartilage_morphology0.85705207
112MP0005395_other_phenotype0.84730874
113MP0001764_abnormal_homeostasis0.84392948
114MP0006036_abnormal_mitochondrial_physio0.83792785
115MP0000685_abnormal_immune_system0.83304078
116MP0002086_abnormal_extraembryonic_tissu0.82749244
117MP0006292_abnormal_olfactory_placode0.82565326
118MP0002085_abnormal_embryonic_tissue0.80293137
119MP0000049_abnormal_middle_ear0.80215450
120MP0000647_abnormal_sebaceous_gland0.79978673
121MP0005389_reproductive_system_phenotype0.79783610
122MP0002163_abnormal_gland_morphology0.77844710
123MP0002084_abnormal_developmental_patter0.77800932
124MP0010155_abnormal_intestine_physiology0.77581578
125MP0009250_abnormal_appendicular_skeleto0.77255358
126MP0005332_abnormal_amino_acid0.76540393
127MP0005023_abnormal_wound_healing0.76251662
128MP0003448_altered_tumor_morphology0.75654180
129MP0004133_heterotaxia0.75530439
130MP0002113_abnormal_skeleton_development0.75310171
131MP0000358_abnormal_cell_content/0.75141491
132MP0002115_abnormal_skeleton_extremities0.74242863
133MP0009672_abnormal_birth_weight0.73975531
134MP0005499_abnormal_olfactory_system0.73572461
135MP0005394_taste/olfaction_phenotype0.73572461
136MP0001529_abnormal_vocalization0.72677595
137MP0000343_altered_response_to0.71777583
138MP0003937_abnormal_limbs/digits/tail_de0.70619625
139MP0005636_abnormal_mineral_homeostasis0.70530668
140MP0001873_stomach_inflammation0.69222853
141MP0002233_abnormal_nose_morphology0.69182963
142MP0009840_abnormal_foam_cell0.68394178
143MP0008873_increased_physiological_sensi0.67879354
144MP0008260_abnormal_autophagy0.67732494
145MP0003315_abnormal_perineum_morphology0.66880129
146MP0001845_abnormal_inflammatory_respons0.66607877
147MP0003699_abnormal_female_reproductive0.65232203
148MP0002111_abnormal_tail_morphology0.65154156
149MP0005621_abnormal_cell_physiology0.63342077
150MP0003787_abnormal_imprinting0.61460075
151MP0005085_abnormal_gallbladder_physiolo0.60352012
152MP0002161_abnormal_fertility/fecundity0.58459462
153MP0001286_abnormal_eye_development0.58272141

Predicted human phenotypes

RankGene SetZ-score
1Irregular epiphyses (HP:0010582)6.70834928
2Small epiphyses (HP:0010585)4.94555390
3Epiphyseal dysplasia (HP:0002656)4.91265725
4Carpal bone hypoplasia (HP:0001498)4.86946717
5Delayed epiphyseal ossification (HP:0002663)4.16253195
6Genu varum (HP:0002970)4.11398531
7Metaphyseal cupping (HP:0003021)3.99207178
8Abnormality of the labia minora (HP:0012880)3.98566448
9Flat capital femoral epiphysis (HP:0003370)3.91268315
10Acute necrotizing encephalopathy (HP:0006965)3.84840987
11Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.84023957
12Absent epiphyses (HP:0010577)3.84023957
13Acute encephalopathy (HP:0006846)3.72089911
14Hepatocellular necrosis (HP:0001404)3.69816398
15Abnormal mitochondria in muscle tissue (HP:0008316)3.60954584
16Abnormal tarsal ossification (HP:0008369)3.55249989
17Birth length less than 3rd percentile (HP:0003561)3.49148097
18Abnormality of femoral epiphyses (HP:0006499)3.48201418
19Abnormality involving the epiphyses of the lower limbs (HP:0006500)3.48201418
20Mitochondrial inheritance (HP:0001427)3.46662415
21Increased CSF lactate (HP:0002490)3.45214187
22Abnormality of the epiphysis of the femoral head (HP:0010574)3.43534500
23Vitreoretinal degeneration (HP:0000655)3.42841939
24Hepatic necrosis (HP:0002605)3.34615596
25Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.25791611
26Abnormal foot bone ossification (HP:0010675)3.22154362
27Cupped ribs (HP:0000887)3.20605016
28Abnormality of the femoral head (HP:0003368)3.18802161
29Increased hepatocellular lipid droplets (HP:0006565)3.14510646
30Reticulocytopenia (HP:0001896)3.09958731
31Short femoral neck (HP:0100864)3.08123017
32Progressive macrocephaly (HP:0004481)3.07945843
33Metaphyseal dysplasia (HP:0100255)3.02330678
34Aplastic anemia (HP:0001915)3.00410491
35Abnormality of the vertebral endplates (HP:0005106)2.96068981
36Breast hypoplasia (HP:0003187)2.95439163
37Hypoplasia of the capital femoral epiphysis (HP:0003090)2.90396974
38Flattened epiphyses (HP:0003071)2.88572582
39Lipid accumulation in hepatocytes (HP:0006561)2.87287646
40Rough bone trabeculation (HP:0100670)2.81738440
41Cerebral edema (HP:0002181)2.81131988
42Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.79796362
43Increased serum lactate (HP:0002151)2.74426080
44Irregular vertebral endplates (HP:0003301)2.71972394
45Mild short stature (HP:0003502)2.71503508
46Abnormal number of erythroid precursors (HP:0012131)2.71183999
4711 pairs of ribs (HP:0000878)2.68573093
48Type I transferrin isoform profile (HP:0003642)2.67046987
49Ependymoma (HP:0002888)2.65295698
50Abnormality of cells of the erythroid lineage (HP:0012130)2.64776298
51Dyschromatopsia (HP:0007641)2.61372380
52Lactic acidosis (HP:0003128)2.60235724
53Abnormality of methionine metabolism (HP:0010901)2.59133832
54Flat acetabular roof (HP:0003180)2.58952816
55Microvesicular hepatic steatosis (HP:0001414)2.58861613
56Hypoplastic ischia (HP:0003175)2.58844260
57Beaking of vertebral bodies (HP:0004568)2.58605899
58Chromsome breakage (HP:0040012)2.56292274
59Abnormality of the proximal phalanges of the hand (HP:0009834)2.55353423
60Oral leukoplakia (HP:0002745)2.52398982
61Abnormality of aspartate family amino acid metabolism (HP:0010899)2.49265506
62Glossoptosis (HP:0000162)2.47833026
63Rhabdomyosarcoma (HP:0002859)2.42394014
64Metaphyseal irregularity (HP:0003025)2.40051027
65Patellar aplasia (HP:0006443)2.38892681
66Abnormal lung lobation (HP:0002101)2.38491969
67Secondary amenorrhea (HP:0000869)2.38347076
68Coxa vara (HP:0002812)2.36924374
69Neoplasm of the adrenal gland (HP:0100631)2.36254842
70Colon cancer (HP:0003003)2.36226293
71Decreased activity of mitochondrial respiratory chain (HP:0008972)2.34022816
72Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.34022816
73Stillbirth (HP:0003826)2.33769948
74Duodenal stenosis (HP:0100867)2.33509180
75Small intestinal stenosis (HP:0012848)2.33509180
76Renal Fanconi syndrome (HP:0001994)2.31959231
77Abnormal protein glycosylation (HP:0012346)2.31550329
78Abnormal glycosylation (HP:0012345)2.31550329
79Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.31550329
80Abnormal protein N-linked glycosylation (HP:0012347)2.31550329
81Abnormality of glycine metabolism (HP:0010895)2.28770205
82Abnormality of serine family amino acid metabolism (HP:0010894)2.28770205
83Increased intramyocellular lipid droplets (HP:0012240)2.27486926
84Meckel diverticulum (HP:0002245)2.27160596
85Abnormality of the anterior horn cell (HP:0006802)2.25874604
86Degeneration of anterior horn cells (HP:0002398)2.25874604
87Abnormality of the duodenum (HP:0002246)2.24875553
88Hyperglycinuria (HP:0003108)2.21586011
89Flared metaphyses (HP:0003015)2.19456578
90Aplasia/Hypoplasia of the patella (HP:0006498)2.17907142
91Chromosomal breakage induced by crosslinking agents (HP:0003221)2.17075808
92Methylmalonic aciduria (HP:0012120)2.15095030
93Myelodysplasia (HP:0002863)2.14792626
94Abnormality of the ileum (HP:0001549)2.13997579
95Respiratory failure (HP:0002878)2.12380368
96Neoplasm of the adrenal cortex (HP:0100641)2.12182023
97Exercise intolerance (HP:0003546)2.09291666
98Medulloblastoma (HP:0002885)2.08697616
99Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07977369
100Thrombocytosis (HP:0001894)2.07237231
101Exertional dyspnea (HP:0002875)2.06789134
102Abnormality of the ischium (HP:0003174)2.05750591
103Poor head control (HP:0002421)2.04691244
104Arthropathy (HP:0003040)2.04442596
105Abnormality of chromosome stability (HP:0003220)2.04439199
106Abnormality of the preputium (HP:0100587)2.04282802
107Nephroblastoma (Wilms tumor) (HP:0002667)2.03472225
108Impulsivity (HP:0100710)2.03416855
109Volvulus (HP:0002580)2.02836613
110Lethargy (HP:0001254)2.02570924
111Aplasia/hypoplasia of the femur (HP:0005613)2.01058892
112Platyspondyly (HP:0000926)1.99779303
113Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.98487751
114Premature ovarian failure (HP:0008209)1.97253865
115Abnormal trabecular bone morphology (HP:0100671)1.96213476
116Intestinal atresia (HP:0011100)1.96194536
117Limited elbow extension (HP:0001377)1.95251934
118Methylmalonic acidemia (HP:0002912)1.93677220
119Biconcave vertebral bodies (HP:0004586)1.93578117
120Mesomelia (HP:0003027)1.93408536
121Generalized aminoaciduria (HP:0002909)1.93263368
122Neoplasm of the colon (HP:0100273)1.93023173
123Abnormality of serum amino acid levels (HP:0003112)1.92718026
124Respiratory difficulties (HP:0002880)1.92253216
125Neonatal short-limb short stature (HP:0008921)1.91736526
126Ulnar deviation of the wrist (HP:0003049)1.90642789
127Glioma (HP:0009733)1.90251515
128Abnormal vertebral ossification (HP:0100569)1.89722911
129Reduced antithrombin III activity (HP:0001976)1.88996232
130Embryonal renal neoplasm (HP:0011794)1.88876826
131Aseptic necrosis (HP:0010885)1.88407191
132Waddling gait (HP:0002515)1.86957516
133Bone marrow hypocellularity (HP:0005528)1.86693332
134Palpitations (HP:0001962)1.86127302
135Aplasia/Hypoplasia of the uvula (HP:0010293)1.86080444
136CNS demyelination (HP:0007305)1.85743956
137Breast carcinoma (HP:0003002)1.85518916
138Aplasia/Hypoplasia of the sacrum (HP:0008517)1.85383781
139Abnormality of the astrocytes (HP:0100707)1.85051585
140Astrocytoma (HP:0009592)1.85051585
141Hyperglycinemia (HP:0002154)1.84403623
142Ectopic kidney (HP:0000086)1.82409369
143Pancytopenia (HP:0001876)1.82319627
144Increased serum pyruvate (HP:0003542)1.80690742
145Leukodystrophy (HP:0002415)1.80447041
146Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.80405958
147Absent thumb (HP:0009777)1.79869425
148Abnormality of sulfur amino acid metabolism (HP:0004339)1.79536563
149Abnormality of carpal bone ossification (HP:0006257)1.79251969
150Hypoplastic pelvis (HP:0008839)1.78699805
151Barrel-shaped chest (HP:0001552)1.78318716
152Osteoarthritis (HP:0002758)1.77583613
153Increased muscle lipid content (HP:0009058)1.77424805
154Optic disc pallor (HP:0000543)1.77270979
155Cutaneous melanoma (HP:0012056)1.76666979
156Triphalangeal thumb (HP:0001199)1.76623920
157Recurrent abscess formation (HP:0002722)1.76619156
158Recurrent cutaneous fungal infections (HP:0011370)1.76243737
159Chronic mucocutaneous candidiasis (HP:0002728)1.76243737
160Pancreatic islet-cell hyperplasia (HP:0004510)1.75339992
161* Sloping forehead (HP:0000340)1.74847349
162Pallor (HP:0000980)1.74548036
163Macrocytic anemia (HP:0001972)1.74246018
164Hypoplasia of the radius (HP:0002984)1.73810634
165Abnormality of glycolysis (HP:0004366)1.73776409
166Abnormal spermatogenesis (HP:0008669)1.73641359
167Horseshoe kidney (HP:0000085)1.72911903
168Cortical dysplasia (HP:0002539)1.72408434
169Spinal muscular atrophy (HP:0007269)1.71821991
170Nausea (HP:0002018)1.71339077
171Constricted visual fields (HP:0001133)1.71220263
172Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.70955736
173IgG deficiency (HP:0004315)1.70409923
174Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.69513085
175Abnormality of the parathyroid morphology (HP:0011766)1.69469923
176Abnormality of the lumbar spine (HP:0100712)1.69453863
177Petechiae (HP:0000967)1.68798684
178Recurrent bacterial skin infections (HP:0005406)1.67416607
179Spinal cord compression (HP:0002176)1.66046328
180Ovoid vertebral bodies (HP:0003300)1.65595292
181Abnormality of the acetabulum (HP:0003170)1.64436955

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.40368894
2VRK24.18026592
3EIF2AK13.91519441
4WEE13.46668450
5PLK43.22115163
6TRIM283.19831523
7CDC73.05895905
8NME22.55295144
9STK162.50582110
10TAF12.38980966
11MST42.38832723
12NEK22.34182154
13PIM22.25173608
14SRPK12.24735072
15BRSK22.22855867
16MAP4K22.09570795
17TLK12.01326656
18TTK1.96938437
19ACVR1B1.87952227
20EIF2AK31.85732962
21PLK11.83164813
22TXK1.79691935
23RPS6KA41.76796887
24AURKB1.69759355
25STK38L1.69616005
26BCR1.61035460
27NEK11.59190227
28MAP3K101.53512043
29BLK1.51560262
30WNK31.50208531
31DYRK31.50004087
32CSNK1G31.48551473
33CSNK1G11.47687765
34CCNB11.47551764
35PBK1.45491046
36STK101.38626041
37CDK71.38387866
38VRK11.36270816
39STK241.35649485
40CHEK21.33268650
41BRSK11.33208505
42PLK31.27966435
43ATR1.24671668
44IRAK31.21344643
45CDK41.20079612
46CSNK1A1L1.19070177
47PIM11.17048522
48CSNK1G21.16532744
49MAP3K31.14490083
50MELK1.14399843
51STK41.13268550
52MKNK11.12852579
53NME11.10415028
54CDK81.09553665
55FRK1.08040606
56MAP3K81.04878495
57MUSK1.03616990
58TYK21.01350481
59TESK20.98662232
60AURKA0.98563623
61IRAK40.97332764
62TSSK60.95028324
63MKNK20.94931159
64EIF2AK20.94629058
65DAPK10.93985883
66MAP3K120.91069681
67ABL20.90658258
68BTK0.89921428
69STK30.89642775
70RPS6KB20.88711015
71TEC0.87955543
72PASK0.85659226
73TGFBR10.85531357
74BRAF0.84480572
75MAP4K10.83337112
76IKBKB0.82286772
77ZAK0.81698189
78NEK90.79640777
79GRK10.79308069
80BMPR1B0.78894142
81CHEK10.76263506
82PLK20.72005406
83TNIK0.70581433
84ADRBK20.69688346
85BCKDK0.69666512
86TESK10.69143688
87NLK0.68065114
88MARK30.67515561
89* ATM0.63372312
90LRRK20.61648846
91SIK30.60661529
92CHUK0.59925849
93DYRK20.59672289
94PRKG20.59210901
95MAP3K110.59103229
96CSNK2A10.58586382
97TAOK30.57852054
98ERBB30.57560960
99CDK20.56077988
100CDK60.53292803
101PRKCI0.51264730
102KIT0.49295160
103MAP2K70.48930325
104LYN0.47890390
105CDK90.47606201
106NUAK10.46665751
107PAK40.46659203
108PDK20.46311950
109TBK10.45049538
110MOS0.45012428
111MAPK40.44928616
112FGR0.42961354
113PINK10.42906978
114CSNK2A20.42772898
115PAK10.42358192
116PDK30.42351354
117PDK40.42351354
118CDK120.41601575
119KDR0.40341453
120MAP2K30.40326927
121CDK10.38721905
122MAP3K60.38375005
123RAF10.38274671
124MAP3K50.37947764
125INSRR0.37765946
126STK390.36119382
127RPS6KA50.35905641
128IKBKE0.35390486
129JAK30.33305437
130MAPKAPK30.31808765
131ILK0.31081751
132SMG10.30006666
133CSNK1E0.28777322
134WNK40.28269410
135AKT20.27752143
136MAP3K40.27169475
137OXSR10.27133693
138ALK0.25745256
139* PRKDC0.23621691
140CSNK1A10.23285110
141BMX0.20001979

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.28850570
2Ribosome_Homo sapiens_hsa030103.53396637
3Mismatch repair_Homo sapiens_hsa034303.45023313
4Proteasome_Homo sapiens_hsa030503.41825867
5Homologous recombination_Homo sapiens_hsa034403.34887701
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.19212550
7RNA polymerase_Homo sapiens_hsa030202.99802971
8Caffeine metabolism_Homo sapiens_hsa002322.79388771
9Base excision repair_Homo sapiens_hsa034102.77155942
10RNA transport_Homo sapiens_hsa030132.70197923
11Cell cycle_Homo sapiens_hsa041102.68480414
12Pyrimidine metabolism_Homo sapiens_hsa002402.49620519
13Spliceosome_Homo sapiens_hsa030402.38107119
14One carbon pool by folate_Homo sapiens_hsa006702.34709193
15Nucleotide excision repair_Homo sapiens_hsa034202.34504492
16Fanconi anemia pathway_Homo sapiens_hsa034602.22267525
17Basal transcription factors_Homo sapiens_hsa030221.93663379
18Propanoate metabolism_Homo sapiens_hsa006401.91193720
19RNA degradation_Homo sapiens_hsa030181.86222355
20Vitamin B6 metabolism_Homo sapiens_hsa007501.65273377
21Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.61214004
22Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.58457630
23p53 signaling pathway_Homo sapiens_hsa041151.58061220
24Protein export_Homo sapiens_hsa030601.57934065
25Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.50344702
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49523208
27Sulfur metabolism_Homo sapiens_hsa009201.48352646
28Fatty acid elongation_Homo sapiens_hsa000621.47230534
29* Non-homologous end-joining_Homo sapiens_hsa034501.41230001
30Steroid biosynthesis_Homo sapiens_hsa001001.39010793
31Purine metabolism_Homo sapiens_hsa002301.34128645
32Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.33343811
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.32945094
34Drug metabolism - other enzymes_Homo sapiens_hsa009831.32197332
35Folate biosynthesis_Homo sapiens_hsa007901.31796285
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.28024423
37Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.27124818
38Selenocompound metabolism_Homo sapiens_hsa004501.16607391
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.13067774
40Epstein-Barr virus infection_Homo sapiens_hsa051691.12369414
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.11899441
42Pyruvate metabolism_Homo sapiens_hsa006201.10504177
43Legionellosis_Homo sapiens_hsa051341.07320087
44Herpes simplex infection_Homo sapiens_hsa051681.03155048
45Alzheimers disease_Homo sapiens_hsa050100.97754035
46Peroxisome_Homo sapiens_hsa041460.97427973
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.97196875
48Pentose phosphate pathway_Homo sapiens_hsa000300.96766663
49mRNA surveillance pathway_Homo sapiens_hsa030150.94977071
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.84854147
51Antigen processing and presentation_Homo sapiens_hsa046120.83978449
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.79955739
53Biosynthesis of amino acids_Homo sapiens_hsa012300.76335724
54Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73890031
55Tryptophan metabolism_Homo sapiens_hsa003800.70019170
56Oocyte meiosis_Homo sapiens_hsa041140.66976605
57Galactose metabolism_Homo sapiens_hsa000520.66362191
58Fatty acid metabolism_Homo sapiens_hsa012120.65019543
59Fat digestion and absorption_Homo sapiens_hsa049750.64747063
60Huntingtons disease_Homo sapiens_hsa050160.64707532
61Primary immunodeficiency_Homo sapiens_hsa053400.64386970
62Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64243519
63HTLV-I infection_Homo sapiens_hsa051660.64094890
64Butanoate metabolism_Homo sapiens_hsa006500.61357342
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.61297501
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60866132
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.60429266
68Glutathione metabolism_Homo sapiens_hsa004800.60045754
69Malaria_Homo sapiens_hsa051440.59398792
70Measles_Homo sapiens_hsa051620.59184799
71Leishmaniasis_Homo sapiens_hsa051400.58720406
72Nitrogen metabolism_Homo sapiens_hsa009100.58309274
73Cyanoamino acid metabolism_Homo sapiens_hsa004600.58266942
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.57876017
75Viral carcinogenesis_Homo sapiens_hsa052030.57759482
76Sulfur relay system_Homo sapiens_hsa041220.56934502
77Systemic lupus erythematosus_Homo sapiens_hsa053220.55262073
78Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54152455
79Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52829535
80Apoptosis_Homo sapiens_hsa042100.52554391
81Fatty acid degradation_Homo sapiens_hsa000710.52383456
82N-Glycan biosynthesis_Homo sapiens_hsa005100.51808657
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47709827
84Arachidonic acid metabolism_Homo sapiens_hsa005900.47487501
85Intestinal immune network for IgA production_Homo sapiens_hsa046720.47262138
86TGF-beta signaling pathway_Homo sapiens_hsa043500.46887904
87Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44161695
88Maturity onset diabetes of the young_Homo sapiens_hsa049500.43261251
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42652190
90Hepatitis B_Homo sapiens_hsa051610.41822993
91Parkinsons disease_Homo sapiens_hsa050120.41391355
92Carbon metabolism_Homo sapiens_hsa012000.41315016
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.40929593
94RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.38938836
95Collecting duct acid secretion_Homo sapiens_hsa049660.38256577
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.38222189
97NOD-like receptor signaling pathway_Homo sapiens_hsa046210.37743528
98Graft-versus-host disease_Homo sapiens_hsa053320.36919536
99Metabolic pathways_Homo sapiens_hsa011000.35649355
100Thyroid cancer_Homo sapiens_hsa052160.35369148
101Small cell lung cancer_Homo sapiens_hsa052220.34952213
102Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34780311
103Hematopoietic cell lineage_Homo sapiens_hsa046400.33283490
104SNARE interactions in vesicular transport_Homo sapiens_hsa041300.32320945
105Influenza A_Homo sapiens_hsa051640.32041041
106Oxidative phosphorylation_Homo sapiens_hsa001900.31309283
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.31239718
108Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.30750551
109Fructose and mannose metabolism_Homo sapiens_hsa000510.30649660
110Regulation of autophagy_Homo sapiens_hsa041400.30526829
111MicroRNAs in cancer_Homo sapiens_hsa052060.30383002
112beta-Alanine metabolism_Homo sapiens_hsa004100.30073373
113Phototransduction_Homo sapiens_hsa047440.30007225
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.29147494
115Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28141708
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.27704218
117Chemical carcinogenesis_Homo sapiens_hsa052040.27201910
118Primary bile acid biosynthesis_Homo sapiens_hsa001200.26942217
119Arginine and proline metabolism_Homo sapiens_hsa003300.26087958
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.24761117
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.23483954
122Bladder cancer_Homo sapiens_hsa052190.23044061
123HIF-1 signaling pathway_Homo sapiens_hsa040660.22163210
124Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21485764
125Steroid hormone biosynthesis_Homo sapiens_hsa001400.20066414
126Sphingolipid metabolism_Homo sapiens_hsa006000.18629586
127Linoleic acid metabolism_Homo sapiens_hsa005910.17473102
128ECM-receptor interaction_Homo sapiens_hsa045120.15755386
129alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.15569778
130Vitamin digestion and absorption_Homo sapiens_hsa049770.15522923
131Asthma_Homo sapiens_hsa053100.14342479
132Starch and sucrose metabolism_Homo sapiens_hsa005000.13582980
133Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.13478602
134Glycerolipid metabolism_Homo sapiens_hsa005610.12671219
135Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.12498380
136Retinol metabolism_Homo sapiens_hsa008300.12027673
137Allograft rejection_Homo sapiens_hsa053300.11808786

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