NHLH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The helix-loop-helix (HLH) proteins are a family of putative transcription factors, some of which have been shown to play an important role in growth and development of a wide variety of tissues and species. Four members of this family have been clearly implicated in tumorigenesis via their involvement in chromosomal translocations in lymphoid tumors: MYC (MIM 190080), LYL1 (MIM 151440), E2A (MIM 147141), and SCL (MIM 187040). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)7.38796939
2regulation of chromatin binding (GO:0035561)6.72986027
3pyrimidine nucleobase catabolic process (GO:0006208)6.42356189
4axonal fasciculation (GO:0007413)5.99014753
5spinal cord development (GO:0021510)5.60381120
6positive regulation of synaptic transmission, dopaminergic (GO:0032226)5.41892604
7peristalsis (GO:0030432)5.28502750
8positive regulation of growth hormone secretion (GO:0060124)5.10000296
9neurofilament cytoskeleton organization (GO:0060052)5.07380002
10neuronal stem cell maintenance (GO:0097150)4.82847074
11auditory behavior (GO:0031223)4.77047229
12regulation of synapse structural plasticity (GO:0051823)4.73574451
13ovulation cycle (GO:0042698)4.70980400
14neuron projection extension involved in neuron projection guidance (GO:1902284)4.69465679
15axon extension involved in axon guidance (GO:0048846)4.69465679
16nucleobase catabolic process (GO:0046113)4.68308896
17spinal cord association neuron differentiation (GO:0021527)4.68259944
18establishment of mitochondrion localization (GO:0051654)4.66054563
19establishment of mitochondrion localization, microtubule-mediated (GO:0034643)4.59047698
20mitochondrion transport along microtubule (GO:0047497)4.59047698
21sequestering of actin monomers (GO:0042989)4.58705800
22central nervous system myelination (GO:0022010)4.57806488
23axon ensheathment in central nervous system (GO:0032291)4.57806488
24glial cell proliferation (GO:0014009)4.50712810
25neuron recognition (GO:0008038)4.47909246
26ganglion development (GO:0061548)4.47065936
27regulation of growth hormone secretion (GO:0060123)4.43034499
28central nervous system projection neuron axonogenesis (GO:0021952)4.31341756
29negative regulation of axon guidance (GO:1902668)4.27137719
30dosage compensation (GO:0007549)4.24935296
31negative regulation of transcription regulatory region DNA binding (GO:2000678)4.23747111
32mating behavior (GO:0007617)4.16821753
33negative regulation of axon extension involved in axon guidance (GO:0048843)4.14982962
34cerebellum development (GO:0021549)4.11898315
35protein-DNA complex disassembly (GO:0032986)4.09602912
36nucleosome disassembly (GO:0006337)4.09602912
37negative regulation of axon extension (GO:0030517)4.07354623
38paraxial mesoderm development (GO:0048339)4.07063776
39neuron fate determination (GO:0048664)4.05911712
40behavioral response to ethanol (GO:0048149)4.01469084
41positive regulation of gastrulation (GO:2000543)3.96820019
42negative regulation of cytosolic calcium ion concentration (GO:0051481)3.96290501
43negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.95178710
44layer formation in cerebral cortex (GO:0021819)3.94484090
45neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.91322773
46mechanosensory behavior (GO:0007638)3.89710339
47cellular response to prostaglandin stimulus (GO:0071379)3.85703289
48cerebellar Purkinje cell differentiation (GO:0021702)3.84223675
49regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.83666834
50auditory receptor cell differentiation (GO:0042491)3.83175010
51negative regulation of neurotransmitter secretion (GO:0046929)3.80811122
52dendritic spine morphogenesis (GO:0060997)3.80517978
53cell migration in hindbrain (GO:0021535)3.79490547
54forebrain neuron differentiation (GO:0021879)3.78715052
55neuronal ion channel clustering (GO:0045161)3.73419031
56negative regulation of microtubule polymerization (GO:0031115)3.70146321
57negative regulation of oligodendrocyte differentiation (GO:0048715)3.67128414
58negative regulation of catecholamine secretion (GO:0033604)3.66053626
59transmission of nerve impulse (GO:0019226)3.61941044
60synapse assembly (GO:0007416)3.61829662
61retinal ganglion cell axon guidance (GO:0031290)3.56310993
62limb bud formation (GO:0060174)3.55812788
63neuromuscular synaptic transmission (GO:0007274)3.54652305
64synaptic transmission, dopaminergic (GO:0001963)3.52387962
65regulation of NFAT protein import into nucleus (GO:0051532)3.51873579
66cell differentiation in spinal cord (GO:0021515)3.44119639
67synaptic transmission, cholinergic (GO:0007271)3.43208504
68olfactory bulb development (GO:0021772)3.41164665
69neuron migration (GO:0001764)3.40414647
70regulation of somitogenesis (GO:0014807)3.40273141
71central nervous system neuron axonogenesis (GO:0021955)3.38114470
72cornea development in camera-type eye (GO:0061303)3.37064180
73regulation of neuron migration (GO:2001222)3.34273310
74motor neuron axon guidance (GO:0008045)3.33663054
75regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.33600126
76axon extension (GO:0048675)3.32889723
77establishment of nucleus localization (GO:0040023)3.32355060
78negative regulation of catenin import into nucleus (GO:0035414)3.31770691
79striatum development (GO:0021756)3.31288317
80hippocampus development (GO:0021766)3.29903079
81response to inactivity (GO:0014854)3.27315803
82negative regulation of glial cell proliferation (GO:0060253)3.26994877
83urogenital system development (GO:0001655)3.26945822
84regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.25288892
85regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.25288892
86lens morphogenesis in camera-type eye (GO:0002089)3.25060488
87response to auditory stimulus (GO:0010996)3.23010954
88semaphorin-plexin signaling pathway (GO:0071526)3.20835893
89regulation of alternative mRNA splicing, via spliceosome (GO:0000381)3.20492697
90prepulse inhibition (GO:0060134)3.20389532
91adult walking behavior (GO:0007628)3.19509351
92cardiac ventricle formation (GO:0003211)3.18674615
93locomotory exploration behavior (GO:0035641)3.16818581
94response to histamine (GO:0034776)3.14457094
95forebrain development (GO:0030900)3.14316036
96cranial nerve development (GO:0021545)3.13875817
97tachykinin receptor signaling pathway (GO:0007217)3.13343570
98snRNA transcription (GO:0009301)3.12299664
99eyelid development in camera-type eye (GO:0061029)3.11264595
100epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.10346689
101cerebral cortex radially oriented cell migration (GO:0021799)3.10311991
102substrate-independent telencephalic tangential migration (GO:0021826)3.09660661
103substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.09660661
104peptidyl-arginine omega-N-methylation (GO:0035247)3.07840688
105body morphogenesis (GO:0010171)3.07156864
106regulation of dopamine secretion (GO:0014059)3.06785202
107phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.05441670
108adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)3.04737929
109behavioral response to cocaine (GO:0048148)3.04586898
110peptidyl-arginine N-methylation (GO:0035246)3.04170313
111peptidyl-arginine methylation (GO:0018216)3.04170313
112dendrite morphogenesis (GO:0048813)3.03469710
113protein localization to synapse (GO:0035418)3.03369812
114positive regulation of synapse maturation (GO:0090129)3.03368512
115cell proliferation in forebrain (GO:0021846)3.03335342
116head development (GO:0060322)3.03146258
117regulation of mRNA splicing, via spliceosome (GO:0048024)3.02449428
118postsynaptic membrane organization (GO:0001941)3.01967126
119uterus development (GO:0060065)2.96587160
120regulation of axon guidance (GO:1902667)2.96576320
121central nervous system neuron differentiation (GO:0021953)2.95846630
122neuron fate specification (GO:0048665)2.93533856
123positive regulation of RNA splicing (GO:0033120)2.90281192
124positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.89739654
125heart valve formation (GO:0003188)2.88172428
126exploration behavior (GO:0035640)2.87806176
127embryonic body morphogenesis (GO:0010172)2.87108347
128regulation of cilium movement (GO:0003352)2.86809059
129pattern specification involved in kidney development (GO:0061004)2.86584955
130sympathetic nervous system development (GO:0048485)2.85581277
131endocardial cushion morphogenesis (GO:0003203)2.85491415
132barbed-end actin filament capping (GO:0051016)2.85241671
133planar cell polarity pathway involved in neural tube closure (GO:0090179)2.83975515
134cardiac chamber formation (GO:0003207)2.83323916
135hair cell differentiation (GO:0035315)2.82465043
136synaptic vesicle maturation (GO:0016188)2.82312065
137regulation of microtubule-based movement (GO:0060632)2.81550267
138somite development (GO:0061053)2.81403317
139regulation of transcription regulatory region DNA binding (GO:2000677)2.80380616
140dendrite development (GO:0016358)2.79972104
141neuron cell-cell adhesion (GO:0007158)2.79295437
142neuron projection extension (GO:1990138)2.79026062
143phasic smooth muscle contraction (GO:0014821)2.78567498
144astrocyte differentiation (GO:0048708)2.77962234
145negative regulation of axonogenesis (GO:0050771)2.77056628
146regulation of axon extension (GO:0030516)2.76908865
147neural tube development (GO:0021915)2.76535919
148neuron maturation (GO:0042551)2.76427533
149calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.76325975
150response to nicotine (GO:0035094)2.75871809
151midbrain development (GO:0030901)2.74759160
152G-protein coupled receptor internalization (GO:0002031)2.74160102
153cerebral cortex development (GO:0021987)2.72763221
154epithelial cilium movement (GO:0003351)2.72753485
155hindbrain development (GO:0030902)2.72393616
156establishment of monopolar cell polarity (GO:0061162)2.72116839
157establishment or maintenance of monopolar cell polarity (GO:0061339)2.72116839
158regulation of axon extension involved in axon guidance (GO:0048841)2.71875279
159cranial nerve morphogenesis (GO:0021602)2.71754168
160stress granule assembly (GO:0034063)2.71400779
161membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.71309553
162cell differentiation in hindbrain (GO:0021533)2.70844952
163protein polyglutamylation (GO:0018095)2.69949732
164presynaptic membrane organization (GO:0097090)2.69938258
165sensory perception of smell (GO:0007608)2.69747321
166negative regulation of neurotransmitter transport (GO:0051589)2.68472456

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.18353544
2RBPJ_22232070_ChIP-Seq_NCS_Mouse3.56564957
3EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.97730956
4TP63_19390658_ChIP-ChIP_HaCaT_Human2.97081812
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.96447972
6EED_16625203_ChIP-ChIP_MESCs_Mouse2.95950283
7NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.82781345
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.79702703
9RNF2_18974828_ChIP-Seq_MESCs_Mouse2.79702703
10TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.75445381
11PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.71888840
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.68597652
13RNF2_27304074_Chip-Seq_ESCs_Mouse2.67767973
14EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.51205344
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.49894667
16ZFP281_18757296_ChIP-ChIP_E14_Mouse2.49658299
17BMI1_23680149_ChIP-Seq_NPCS_Mouse2.48619794
18OLIG2_26023283_ChIP-Seq_AINV15_Mouse2.45240502
19EZH2_27294783_Chip-Seq_ESCs_Mouse2.42491674
20SOX2_18555785_ChIP-Seq_MESCs_Mouse2.38391863
21CBX2_27304074_Chip-Seq_ESCs_Mouse2.37429939
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.35583600
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.26907678
24RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.26602372
25* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.24570692
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.23043021
27* RING1B_27294783_Chip-Seq_ESCs_Mouse2.12537378
28SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.09883135
29SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.09476903
30RING1B_27294783_Chip-Seq_NPCs_Mouse2.08293900
31ZFP281_27345836_Chip-Seq_ESCs_Mouse2.02660245
32TP53_20018659_ChIP-ChIP_R1E_Mouse1.98365860
33SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.98164117
34POU5F1_16153702_ChIP-ChIP_HESCs_Human1.94067466
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.89600241
36RNF2_27304074_Chip-Seq_NSC_Mouse1.77254988
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.74119671
38KDM2B_26808549_Chip-Seq_K562_Human1.73881504
39SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.73213663
40REST_21632747_ChIP-Seq_MESCs_Mouse1.69768446
41KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.56340004
42DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.55234924
43* MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.51961605
44WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.49876695
45DROSHA_22980978_ChIP-Seq_HELA_Human1.46669667
46SOX2_16153702_ChIP-ChIP_HESCs_Human1.46453450
47REST_18959480_ChIP-ChIP_MESCs_Mouse1.46136702
48* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.46051851
49GATA1_26923725_Chip-Seq_HPCs_Mouse1.42615570
50SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41683569
51* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.41341299
52MTF2_20144788_ChIP-Seq_MESCs_Mouse1.38538308
53TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.33274886
54POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.33274886
55GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.32467814
56FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.29466234
57TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.22469708
58PKCTHETA_26484144_Chip-Seq_BREAST_Human1.21224584
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19383413
60MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.18602159
61HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.18221191
62* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17551474
63WT1_19549856_ChIP-ChIP_CCG9911_Human1.17364862
64CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17110317
65ZNF274_21170338_ChIP-Seq_K562_Hela1.16519055
66TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.16281174
67ISL1_27105846_Chip-Seq_CPCs_Mouse1.15156891
68AHR_22903824_ChIP-Seq_MCF-7_Human1.14800582
69STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14293849
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.13274559
71SOX3_22085726_ChIP-Seq_NPCs_Mouse1.11552200
72SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.10320544
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.09860253
74CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08359498
75POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.08014621
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.07847157
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07656333
78CIITA_25753668_ChIP-Seq_RAJI_Human1.07041085
79IRF1_19129219_ChIP-ChIP_H3396_Human1.06207290
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04965545
81RUNX1_26923725_Chip-Seq_HPCs_Mouse1.04614380
82NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04019645
83KDM2B_26808549_Chip-Seq_JURKAT_Human1.03702760
84WT1_25993318_ChIP-Seq_PODOCYTE_Human1.03648941
85ZFP57_27257070_Chip-Seq_ESCs_Mouse1.03546094
86IGF1R_20145208_ChIP-Seq_DFB_Human1.00568175
87RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.00483440
88STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.00268015
89WDR5_24793694_ChIP-Seq_LNCAP_Human0.99682682
90CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99051576
91KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.96853817
92EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.96506687
93POU5F1_16518401_ChIP-PET_MESCs_Mouse0.95915689
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95330796
95ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95088404
96SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95083641
97KDM2B_26808549_Chip-Seq_DND41_Human0.94275170
98CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.93873890
99* IKZF1_21737484_ChIP-ChIP_HCT116_Human0.93645312
100RARB_27405468_Chip-Seq_BRAIN_Mouse0.92707978
101MYC_22102868_ChIP-Seq_BL_Human0.92248807
102NANOG_21062744_ChIP-ChIP_HESCs_Human0.90747737
103NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.90656214
104MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.89857443
105P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89822049
106CTCF_27219007_Chip-Seq_Bcells_Human0.88904580
107ARNT_22903824_ChIP-Seq_MCF-7_Human0.88521039
108TOP2B_26459242_ChIP-Seq_MCF-7_Human0.85238804
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84875508
110FOXM1_23109430_ChIP-Seq_U2OS_Human0.84561322
111SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83468052
112SMAD3_21741376_ChIP-Seq_ESCs_Human0.82636498
113ETV2_25802403_ChIP-Seq_MESCs_Mouse0.81891725
114MNX1_26342078_ChIP-Seq_MIN6-4N_Mouse0.81808334
115GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81620043
116GBX2_23144817_ChIP-Seq_PC3_Human0.81469205
117POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.81360278
118CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.81323331
119DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79762564
120SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.78583638
121YAP1_20516196_ChIP-Seq_MESCs_Mouse0.78312648
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.77965951
123UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.77761183
124MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.77532760
125VDR_22108803_ChIP-Seq_LS180_Human0.76490146
126* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.76318315
127ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.76288092
128CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.75956530
129STAT3_18555785_ChIP-Seq_MESCs_Mouse0.75175580
130FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.75051707
131SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.75048303
132P300_19829295_ChIP-Seq_ESCs_Human0.74922320
133SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.74349860
134OCT4_19829295_ChIP-Seq_ESCs_Human0.70888261

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy5.45390401
2MP0008789_abnormal_olfactory_epithelium5.40187318
3MP0005499_abnormal_olfactory_system4.64669131
4MP0005394_taste/olfaction_phenotype4.64669131
5MP0002653_abnormal_ependyma_morphology4.08597873
6MP0000778_abnormal_nervous_system3.47275966
7MP0005187_abnormal_penis_morphology3.32820007
8MP0003123_paternal_imprinting3.28819500
9MP0003787_abnormal_imprinting3.22769565
10MP0001188_hyperpigmentation3.22363056
11MP0005423_abnormal_somatic_nervous3.05812022
12MP0005645_abnormal_hypothalamus_physiol2.99281733
13MP0001529_abnormal_vocalization2.62762252
14MP0001984_abnormal_olfaction2.56117734
15MP0003315_abnormal_perineum_morphology2.49984909
16MP0010030_abnormal_orbit_morphology2.39751813
17MP0002909_abnormal_adrenal_gland2.30271106
18MP0002184_abnormal_innervation2.30243004
19MP0002233_abnormal_nose_morphology2.07643858
20MP0002938_white_spotting2.01025343
21MP0003861_abnormal_nervous_system2.00049393
22MP0002751_abnormal_autonomic_nervous1.96009315
23MP0008995_early_reproductive_senescence1.89332381
24MP0000631_abnormal_neuroendocrine_gland1.84498010
25MP0000566_synostosis1.83196476
26MP0005409_darkened_coat_color1.82028422
27MP0002163_abnormal_gland_morphology1.81548914
28MP0003880_abnormal_central_pattern1.78965007
29MP0002638_abnormal_pupillary_reflex1.78463484
30MP0000537_abnormal_urethra_morphology1.73565466
31MP0002272_abnormal_nervous_system1.73343255
32MP0004270_analgesia1.72905383
33MP0004859_abnormal_synaptic_plasticity1.72712837
34MP0003122_maternal_imprinting1.66910754
35MP0001905_abnormal_dopamine_level1.66890425
36MP0004133_heterotaxia1.57310700
37MP0000955_abnormal_spinal_cord1.55868297
38MP0009379_abnormal_foot_pigmentation1.54449301
39MP0004134_abnormal_chest_morphology1.54424810
40MP0003121_genomic_imprinting1.52576752
41MP0003942_abnormal_urinary_system1.51669395
42MP0002152_abnormal_brain_morphology1.50846569
43MP0002102_abnormal_ear_morphology1.49417184
44MP0000026_abnormal_inner_ear1.47645180
45MP0004145_abnormal_muscle_electrophysio1.43876951
46* MP0002882_abnormal_neuron_morphology1.43416908
47MP0002752_abnormal_somatic_nervous1.43033598
48MP0009745_abnormal_behavioral_response1.42588563
49MP0005377_hearing/vestibular/ear_phenot1.40369177
50MP0003878_abnormal_ear_physiology1.40369177
51MP0003890_abnormal_embryonic-extraembry1.39361825
52MP0002572_abnormal_emotion/affect_behav1.39024292
53MP0000647_abnormal_sebaceous_gland1.38665608
54MP0006292_abnormal_olfactory_placode1.36566321
55MP0004858_abnormal_nervous_system1.36258948
56MP0002735_abnormal_chemical_nociception1.35154861
57MP0001293_anophthalmia1.34818221
58MP0002116_abnormal_craniofacial_bone1.34777923
59MP0004142_abnormal_muscle_tone1.34148071
60MP0004885_abnormal_endolymph1.32513806
61MP0003385_abnormal_body_wall1.30926449
62MP0001485_abnormal_pinna_reflex1.30034260
63MP0000049_abnormal_middle_ear1.29667584
64MP0002932_abnormal_joint_morphology1.29525630
65MP0004811_abnormal_neuron_physiology1.28466288
66MP0005646_abnormal_pituitary_gland1.27665794
67MP0002557_abnormal_social/conspecific_i1.27042826
68MP0001348_abnormal_lacrimal_gland1.27023424
69MP0001440_abnormal_grooming_behavior1.22730639
70MP0002249_abnormal_larynx_morphology1.21858356
71MP0002081_perinatal_lethality1.20860611
72MP0001970_abnormal_pain_threshold1.19930943
73MP0009046_muscle_twitch1.19565870
74MP0002734_abnormal_mechanical_nocicepti1.19402472
75MP0003119_abnormal_digestive_system1.14511868
76MP0001286_abnormal_eye_development1.14185725
77MP0001486_abnormal_startle_reflex1.14115761
78MP0000534_abnormal_ureter_morphology1.12579326
79MP0001968_abnormal_touch/_nociception1.12494985
80MP0004742_abnormal_vestibular_system1.12287725
81MP0005248_abnormal_Harderian_gland1.11897917
82MP0003938_abnormal_ear_development1.10394333
83MP0004924_abnormal_behavior1.09714957
84MP0005386_behavior/neurological_phenoty1.09714957
85MP0009250_abnormal_appendicular_skeleto1.09611825
86MP0000569_abnormal_digit_pigmentation1.09130521
87MP0003755_abnormal_palate_morphology1.07304975
88MP0002733_abnormal_thermal_nociception1.05614127
89MP0002092_abnormal_eye_morphology1.05496258
90MP0003935_abnormal_craniofacial_develop1.05127834
91MP0001346_abnormal_lacrimal_gland1.04302086
92MP0002064_seizures1.03543474
93MP0002282_abnormal_trachea_morphology1.01364701
94MP0001324_abnormal_eye_pigmentation0.95122545
95* MP0006276_abnormal_autonomic_nervous0.94852319
96MP0000428_abnormal_craniofacial_morphol0.93663014
97MP0000538_abnormal_urinary_bladder0.92635610
98MP0010386_abnormal_urinary_bladder0.92516925
99MP0002160_abnormal_reproductive_system0.90869062
100MP0003011_delayed_dark_adaptation0.90097005
101MP0003635_abnormal_synaptic_transmissio0.89891431
102MP0002928_abnormal_bile_duct0.89296470
103MP0002063_abnormal_learning/memory/cond0.89104515
104MP0009703_decreased_birth_body0.87947000
105MP0008877_abnormal_DNA_methylation0.86309921
106MP0001849_ear_inflammation0.84177885
107MP0001963_abnormal_hearing_physiology0.82912160
108MP0000432_abnormal_head_morphology0.82424971
109* MP0002067_abnormal_sensory_capabilities0.82421818
110MP0005389_reproductive_system_phenotype0.82373966
111MP0005391_vision/eye_phenotype0.81618386
112MP0002085_abnormal_embryonic_tissue0.81420057
113MP0005551_abnormal_eye_electrophysiolog0.80696131
114* MP0002066_abnormal_motor_capabilities/c0.79294412
115MP0003948_abnormal_gas_homeostasis0.78907295
116MP0002697_abnormal_eye_size0.78660097
117MP0005197_abnormal_uvea_morphology0.77903170
118MP0001919_abnormal_reproductive_system0.77741848
119MP0002084_abnormal_developmental_patter0.77679141
120MP0003937_abnormal_limbs/digits/tail_de0.77625671
121MP0005253_abnormal_eye_physiology0.77577542
122MP0001299_abnormal_eye_distance/0.76552222
123MP0005379_endocrine/exocrine_gland_phen0.76398422
124MP0002114_abnormal_axial_skeleton0.76229537
125MP0000733_abnormal_muscle_development0.75403840
126MP0002111_abnormal_tail_morphology0.73785014
127MP0003115_abnormal_respiratory_system0.72278011
128MP0005195_abnormal_posterior_eye0.71973513
129MP0002229_neurodegeneration0.71285879
130MP0006072_abnormal_retinal_apoptosis0.71233880
131MP0001943_abnormal_respiration0.70934164
132MP0002876_abnormal_thyroid_physiology0.70825019
133MP0000003_abnormal_adipose_tissue0.68005088
134MP0009672_abnormal_birth_weight0.67942443
135MP0003879_abnormal_hair_cell0.66138111
136MP0005083_abnormal_biliary_tract0.65334636
137MP0000372_irregular_coat_pigmentation0.64530287
138MP0002069_abnormal_eating/drinking_beha0.64204380
139MP0010770_preweaning_lethality0.63435641
140MP0002082_postnatal_lethality0.63435641
141MP0002896_abnormal_bone_mineralization0.62963476
142MP0005257_abnormal_intraocular_pressure0.61827029
143MP0005623_abnormal_meninges_morphology0.60342994
144MP0005076_abnormal_cell_differentiation0.60128787

Predicted human phenotypes

RankGene SetZ-score
1Abnormal pancreas size (HP:0012094)5.29619414
2Anomalous pulmonary venous return (HP:0010772)4.94011527
3Myokymia (HP:0002411)4.78325764
4Abnormality of the pulmonary veins (HP:0011718)4.36173358
5Abnormality of the intervertebral disk (HP:0005108)4.29970415
6Elfin facies (HP:0004428)4.23965012
7Renovascular hypertension (HP:0100817)4.23685362
8Hyperacusis (HP:0010780)4.22566478
9Insomnia (HP:0100785)4.09237527
10Diastasis recti (HP:0001540)4.08453643
11Neonatal hypoglycemia (HP:0001998)3.66230095
12Overriding aorta (HP:0002623)3.63446800
13Short 4th metacarpal (HP:0010044)3.58872114
14Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.58872114
15Renal duplication (HP:0000075)3.58070238
16Pelvic girdle muscle weakness (HP:0003749)3.56895284
17High anterior hairline (HP:0009890)3.46850202
18Agitation (HP:0000713)3.36574274
19Adrenal hypoplasia (HP:0000835)3.30161721
20Sex reversal (HP:0012245)3.14743374
21Abnormal sex determination (HP:0012244)3.14743374
22Metaphyseal dysplasia (HP:0100255)3.11531906
23Aplasia/Hypoplasia of the sternum (HP:0006714)3.10165949
24Abnormality of the diencephalon (HP:0010662)3.06177706
25Abnormality of the hip-girdle musculature (HP:0001445)3.05034804
26Abnormality of the musculature of the pelvis (HP:0001469)3.05034804
27Abnormality of the corticospinal tract (HP:0002492)3.01411084
28Impaired vibration sensation in the lower limbs (HP:0002166)2.99157547
29Flat cornea (HP:0007720)2.96785783
30Spina bifida occulta (HP:0003298)2.95599937
31Trigonocephaly (HP:0000243)2.95414786
32Drooling (HP:0002307)2.80480088
33Abnormality of the lower motor neuron (HP:0002366)2.77136150
34Exotropia (HP:0000577)2.73542246
35Down-sloping shoulders (HP:0200021)2.73212615
36Polyphagia (HP:0002591)2.71626226
37Anosmia (HP:0000458)2.67864524
38Limb dystonia (HP:0002451)2.67149214
39Deep palmar crease (HP:0006191)2.62040084
40Cortical dysplasia (HP:0002539)2.58882879
41Excessive salivation (HP:0003781)2.56693502
42Hypoplasia of the brainstem (HP:0002365)2.56580808
43Aplasia/Hypoplasia of the brainstem (HP:0007362)2.56580808
44Patellar aplasia (HP:0006443)2.55727159
45Patellar dislocation (HP:0002999)2.54118400
46Abnormality of the 4th metacarpal (HP:0010012)2.53714009
47Aplasia/Hypoplasia of the patella (HP:0006498)2.50909498
48Abnormal number of incisors (HP:0011064)2.50267282
49Increased nuchal translucency (HP:0010880)2.49706424
50Poor suck (HP:0002033)2.49514900
51Hepatoblastoma (HP:0002884)2.48643330
52Abnormality of midbrain morphology (HP:0002418)2.47710501
53Molar tooth sign on MRI (HP:0002419)2.47710501
54Focal seizures (HP:0007359)2.40256522
55Nephronophthisis (HP:0000090)2.39146720
56Septo-optic dysplasia (HP:0100842)2.32797454
57Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.32101634
58Broad-based gait (HP:0002136)2.31498801
59Medial flaring of the eyebrow (HP:0010747)2.31297103
60Torticollis (HP:0000473)2.30697855
61Chronic hepatic failure (HP:0100626)2.30482289
62Obsessive-compulsive behavior (HP:0000722)2.28336261
63Abnormality of macular pigmentation (HP:0008002)2.28233318
64Optic nerve coloboma (HP:0000588)2.25110623
65Gait imbalance (HP:0002141)2.23917483
66Focal dystonia (HP:0004373)2.23863134
67Lissencephaly (HP:0001339)2.23779439
68Congenital malformation of the right heart (HP:0011723)2.23159653
69Double outlet right ventricle (HP:0001719)2.23159653
70Slow-growing hair (HP:0002217)2.22135143
71Abnormality of hair growth rate (HP:0011363)2.22135143
72Hallux valgus (HP:0001822)2.20053731
73Wrist flexion contracture (HP:0001239)2.18015693
74Asymmetry of the thorax (HP:0001555)2.14987147
75Renal hypoplasia (HP:0000089)2.13178586
76Spastic tetraplegia (HP:0002510)2.12283531
77Meningocele (HP:0002435)2.10770134
78True hermaphroditism (HP:0010459)2.10166865
79Hemivertebrae (HP:0002937)2.09992693
80Megalocornea (HP:0000485)2.08468465
81Deviation of the hallux (HP:0010051)2.08075871
82Supernumerary ribs (HP:0005815)2.07962507
83Abnormality of the labia minora (HP:0012880)2.07722594
84Progressive cerebellar ataxia (HP:0002073)2.06562422
85Bowel diverticulosis (HP:0005222)2.05393080
86Abnormality of cells of the erythroid lineage (HP:0012130)2.04842993
87Leiomyosarcoma (HP:0100243)2.04116799
88Uterine leiomyosarcoma (HP:0002891)2.04116799
89Vaginal atresia (HP:0000148)2.04106207
90Growth hormone deficiency (HP:0000824)2.03400102
91Overgrowth (HP:0001548)2.03169005
92Incomplete penetrance (HP:0003829)2.02970330
93Hypogonadotrophic hypogonadism (HP:0000044)2.01366855
94Urinary bladder sphincter dysfunction (HP:0002839)2.01199536
95Intellectual disability, moderate (HP:0002342)2.01034500
96Pachygyria (HP:0001302)2.00534102
97Sacral dimple (HP:0000960)1.99037599
98Cutis marmorata (HP:0000965)1.98815604
99Transitional cell carcinoma of the bladder (HP:0006740)1.98159395
100Disproportionate short-trunk short stature (HP:0003521)1.97584785
101Genital tract atresia (HP:0001827)1.96422163
102Neoplasm of the heart (HP:0100544)1.95591707
103Pointed chin (HP:0000307)1.95387681
104Abnormality of the renal medulla (HP:0100957)1.95374777
105Supranuclear gaze palsy (HP:0000605)1.94399592
106Pancreatic fibrosis (HP:0100732)1.92922684
107Nephrogenic diabetes insipidus (HP:0009806)1.92153585
108Bladder diverticulum (HP:0000015)1.91306278
109Hypothermia (HP:0002045)1.91123153
110Periorbital edema (HP:0100539)1.90564337
111Smooth philtrum (HP:0000319)1.90445816
112Congenital primary aphakia (HP:0007707)1.90420164
113Anencephaly (HP:0002323)1.89984563
114Fetal akinesia sequence (HP:0001989)1.88711319
115Bony spicule pigmentary retinopathy (HP:0007737)1.88569638
116Papillary thyroid carcinoma (HP:0002895)1.88096506
117Hyperventilation (HP:0002883)1.87750967
118Abnormal ciliary motility (HP:0012262)1.86038832
119Autism (HP:0000717)1.85800545
120Abnormality of the antihelix (HP:0009738)1.85657926
121Labial hypoplasia (HP:0000066)1.85232710
122Bladder carcinoma (HP:0002862)1.84657887
123Bladder neoplasm (HP:0009725)1.84657887
124Medulloblastoma (HP:0002885)1.84461467
125Midline defect of the nose (HP:0004122)1.84139215
126Epileptic encephalopathy (HP:0200134)1.84004687
127Craniofacial dystonia (HP:0012179)1.83488413
128Type 2 muscle fiber atrophy (HP:0003554)1.83290520
129Polymicrogyria (HP:0002126)1.82343647
130Osteomalacia (HP:0002749)1.81721445
131Cutaneous syndactyly (HP:0012725)1.80298950
132Optic nerve hypoplasia (HP:0000609)1.80245550
133Mask-like facies (HP:0000298)1.79977457
134Neoplasm of the adrenal cortex (HP:0100641)1.79886589
135Thoracolumbar scoliosis (HP:0002944)1.79424759
136Shawl scrotum (HP:0000049)1.79332693
137Focal motor seizures (HP:0011153)1.79217975
138Oligodactyly (HP:0012165)1.78686503
139Anophthalmia (HP:0000528)1.78412729
140Supernumerary bones of the axial skeleton (HP:0009144)1.78338238
141Short philtrum (HP:0000322)1.77324405
142Reticulocytopenia (HP:0001896)1.76917919
143Atelectasis (HP:0100750)1.76262840
144Facial edema (HP:0000282)1.73862948
145Retinal dysplasia (HP:0007973)1.73758560
146Abnormality of dentin (HP:0010299)1.73294469
147Amblyopia (HP:0000646)1.72823991
148Febrile seizures (HP:0002373)1.71313661
149Esophageal atresia (HP:0002032)1.70700383
150Absent rod-and cone-mediated responses on ERG (HP:0007688)1.70578440
151Chorioretinal coloboma (HP:0000567)1.70224498
152Thyroid-stimulating hormone excess (HP:0002925)1.69988523
153Hypercalciuria (HP:0002150)1.69752500
154Hyperthyroidism (HP:0000836)1.69280800
155Dandy-Walker malformation (HP:0001305)1.69203529
156Sprengel anomaly (HP:0000912)1.68635357
157Thick eyebrow (HP:0000574)1.68579972
158Enlarged kidneys (HP:0000105)1.68461555
159Germ cell neoplasia (HP:0100728)1.68370405
160Chorioretinal atrophy (HP:0000533)1.67746634
161Rib fusion (HP:0000902)1.67534007
162Pancreatic cysts (HP:0001737)1.67082632
163Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.66703378
164Intestinal atresia (HP:0011100)1.66443590
165Vesicoureteral reflux (HP:0000076)1.65173564
166Oligodactyly (hands) (HP:0001180)1.65080965
167Shoulder girdle muscle weakness (HP:0003547)1.64898789
168Shallow orbits (HP:0000586)1.63898472
169Glossoptosis (HP:0000162)1.63689452
170Morphological abnormality of the middle ear (HP:0008609)1.63309194
171Concave nail (HP:0001598)1.62925383
172Radioulnar synostosis (HP:0002974)1.62646235

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERBB35.66109090
2EEF2K4.30086886
3MARK12.91927898
4NTRK12.77925359
5SRPK12.69788951
6BMPR22.56653237
7KSR12.53677239
8EPHB22.51130535
9NTRK22.45424436
10MAP3K102.43911224
11TLK12.36353572
12MAPK132.33932694
13STK162.19172297
14IRAK22.06285939
15SIK32.04954613
16FGFR21.99760946
17SIK21.96132166
18TYRO31.89733081
19MKNK11.85613215
20ADRBK21.84210071
21MAPKAPK31.80921696
22BRD41.78723619
23PINK11.74130007
24WNK31.74043336
25EPHA31.69348812
26MATK1.66628246
27PDGFRA1.56983096
28CSNK1A1L1.56439391
29DYRK21.55510936
30WNK41.47693288
31ERBB21.46005101
32CAMK1D1.44747570
33CSNK1G31.44025556
34BCR1.43985099
35PLK41.42842062
36UHMK11.42563566
37PRKCG1.39718835
38MKNK21.37753434
39MARK21.33900363
40DDR21.33122698
41RIPK11.32790598
42PRPF4B1.25557465
43ICK1.23091040
44MAP2K41.20504333
45CSNK1G21.16662049
46MAP3K111.16421953
47EPHA41.14840688
48PKN11.13791914
49STK111.13171804
50RPS6KB21.09793091
51ILK1.08184712
52SIK11.08184378
53CASK1.01898150
54TRIM281.00399216
55RPS6KA20.99891066
56DAPK20.99662032
57CSNK1G10.98041717
58DYRK30.96276273
59MINK10.94548303
60PRKCH0.94082733
61CAMKK10.90834068
62TRIB30.90334135
63IRAK10.87460473
64CAMK10.84655778
65DYRK1B0.81810587
66FGFR40.80601333
67LIMK10.79757913
68MAP2K70.79424298
69CSNK1E0.79048312
70PLK20.77859644
71MAP3K60.77497337
72CDC70.73376603
73SGK2230.73004363
74SGK4940.73004363
75BMPR1B0.70826534
76HIPK20.67432236
77YES10.66797268
78MAP3K40.66211446
79BRAF0.62400734
80FGFR30.61426280
81CDK190.59922630
82PNCK0.59592778
83ROCK20.59062762
84PAK30.58584141
85PRKCZ0.57900985
86CDK30.56366101
87CAMK40.56342712
88CAMK1G0.55685595
89ADRBK10.53548098
90PRKACA0.53395053
91MAPK90.53084301
92NTRK30.52502205
93PRKAA10.51381140
94TNIK0.50880105
95RPS6KA10.50253377
96MAPK150.48939009
97CDC42BPA0.48827057
98PAK60.48515495
99ROCK10.48289448
100CDK180.48043405
101STK240.46368282
102SGK30.45610020
103OXSR10.44990263
104MAP3K90.43147511
105FGFR10.41814385
106LRRK20.41712846
107MTOR0.41396806
108CDK60.41253620
109INSRR0.40102687
110CDK50.39832094
111CDK11A0.39564277
112MAPKAPK20.39378443
113CSNK1A10.39145794
114AKT10.39133451
115PLK30.38969704
116DYRK1A0.38347967
117CAMKK20.38143296
118SGK20.37843593
119CHUK0.37336778
120RPS6KA60.37259140
121CDK150.37056732
122TAOK20.36892151
123GRK10.36847186
124NEK20.36735139
125MAPK110.36576341
126FRK0.36550968
127GRK50.36029628
128STK390.35076406
129TAOK10.33940437
130MAPK80.33588275
131CDK140.33522237
132ZAK0.33488138
133AURKA0.33220532
134PRKG10.33203546
135PHKG10.33104207
136PHKG20.33104207
137BCKDK0.32984828
138PRKCD0.32079274
139ATR0.32005809
140SGK10.31667090
141WNK10.31638662
142DAPK30.31485714
143MAPKAPK50.30673311
144TRPM70.27926280
145GSK3B0.27156241
146CDK90.27023701
147CDK20.26941854
148PTK60.26807929
149CHEK10.26366615
150TESK10.26357415
151DAPK10.25990732

Predicted pathways (KEGG)

RankGene SetZ-score
1Notch signaling pathway_Homo sapiens_hsa043304.00325291
2Olfactory transduction_Homo sapiens_hsa047403.28147083
3Axon guidance_Homo sapiens_hsa043603.26010100
4Basal cell carcinoma_Homo sapiens_hsa052172.96842580
5Cardiac muscle contraction_Homo sapiens_hsa042602.89637835
6Oxidative phosphorylation_Homo sapiens_hsa001902.80863673
7Parkinsons disease_Homo sapiens_hsa050122.80514964
8Endometrial cancer_Homo sapiens_hsa052132.58518767
9Cocaine addiction_Homo sapiens_hsa050302.50261960
10mRNA surveillance pathway_Homo sapiens_hsa030152.45595597
11Colorectal cancer_Homo sapiens_hsa052102.38494124
12Phototransduction_Homo sapiens_hsa047442.34376285
13Hedgehog signaling pathway_Homo sapiens_hsa043402.30406255
14Spliceosome_Homo sapiens_hsa030402.24440859
15Chronic myeloid leukemia_Homo sapiens_hsa052202.18830866
16Ribosome_Homo sapiens_hsa030102.01417190
17Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.88707275
18Glioma_Homo sapiens_hsa052141.85354247
19Steroid biosynthesis_Homo sapiens_hsa001001.81369158
20Alzheimers disease_Homo sapiens_hsa050101.78744836
21Non-small cell lung cancer_Homo sapiens_hsa052231.74554538
22Hippo signaling pathway_Homo sapiens_hsa043901.74170269
23Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.72878207
24Huntingtons disease_Homo sapiens_hsa050161.68906649
25Wnt signaling pathway_Homo sapiens_hsa043101.63861651
26Insulin secretion_Homo sapiens_hsa049111.60530614
27ErbB signaling pathway_Homo sapiens_hsa040121.58693452
28MicroRNAs in cancer_Homo sapiens_hsa052061.57001248
29Dopaminergic synapse_Homo sapiens_hsa047281.50703727
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.48560062
31Collecting duct acid secretion_Homo sapiens_hsa049661.47606262
32Neurotrophin signaling pathway_Homo sapiens_hsa047221.44140128
33Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.42762971
34Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.37959492
35Circadian entrainment_Homo sapiens_hsa047131.34096752
36Bladder cancer_Homo sapiens_hsa052191.30290354
37Tight junction_Homo sapiens_hsa045301.27672538
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.27303747
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24536206
40Cholinergic synapse_Homo sapiens_hsa047251.24176697
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24074057
42Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.23937469
43Pancreatic cancer_Homo sapiens_hsa052121.23241253
44Melanogenesis_Homo sapiens_hsa049161.21585564
45Thyroid hormone signaling pathway_Homo sapiens_hsa049191.21417917
46Alcoholism_Homo sapiens_hsa050341.19997751
47Adherens junction_Homo sapiens_hsa045201.19424267
48Cell cycle_Homo sapiens_hsa041101.18924839
49Morphine addiction_Homo sapiens_hsa050321.18278546
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.17159085
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.16113924
52Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.11967035
53Glutamatergic synapse_Homo sapiens_hsa047241.11924334
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.10982731
55Amphetamine addiction_Homo sapiens_hsa050311.07282369
56Serotonergic synapse_Homo sapiens_hsa047261.04866457
57Gap junction_Homo sapiens_hsa045401.04266111
58GABAergic synapse_Homo sapiens_hsa047271.04203757
59FoxO signaling pathway_Homo sapiens_hsa040681.03753629
60alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03611078
61Lysine degradation_Homo sapiens_hsa003101.03347149
62Melanoma_Homo sapiens_hsa052181.01129468
63cAMP signaling pathway_Homo sapiens_hsa040240.98320259
64Dilated cardiomyopathy_Homo sapiens_hsa054140.97318738
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.95687237
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.95501569
67VEGF signaling pathway_Homo sapiens_hsa043700.93506080
68Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.92937649
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.92839219
70Prolactin signaling pathway_Homo sapiens_hsa049170.92364168
71Renal cell carcinoma_Homo sapiens_hsa052110.91240900
72Pathways in cancer_Homo sapiens_hsa052000.89861699
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.88917749
74Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.88349223
75Estrogen signaling pathway_Homo sapiens_hsa049150.87455180
76Type II diabetes mellitus_Homo sapiens_hsa049300.86284915
77Viral myocarditis_Homo sapiens_hsa054160.85179111
78Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.84534991
79Oocyte meiosis_Homo sapiens_hsa041140.82526855
80Prostate cancer_Homo sapiens_hsa052150.82458415
81Proteoglycans in cancer_Homo sapiens_hsa052050.80837964
82Gastric acid secretion_Homo sapiens_hsa049710.80709203
83Synaptic vesicle cycle_Homo sapiens_hsa047210.80248603
84Insulin signaling pathway_Homo sapiens_hsa049100.77984349
85Carbohydrate digestion and absorption_Homo sapiens_hsa049730.74139534
86Aldosterone synthesis and secretion_Homo sapiens_hsa049250.72999070
87Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71994227
88Linoleic acid metabolism_Homo sapiens_hsa005910.70682958
89HTLV-I infection_Homo sapiens_hsa051660.70099193
90Ras signaling pathway_Homo sapiens_hsa040140.70060956
91Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68864940
92Dorso-ventral axis formation_Homo sapiens_hsa043200.68571461
93Prion diseases_Homo sapiens_hsa050200.68513706
94Taste transduction_Homo sapiens_hsa047420.68313708
95Hepatitis B_Homo sapiens_hsa051610.68266953
96Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68125776
97Choline metabolism in cancer_Homo sapiens_hsa052310.67417500
98AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65786910
99Oxytocin signaling pathway_Homo sapiens_hsa049210.65266400
100Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64889862
101Ether lipid metabolism_Homo sapiens_hsa005650.63195398
102mTOR signaling pathway_Homo sapiens_hsa041500.63170732
103Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63038702
104Hepatitis C_Homo sapiens_hsa051600.62129682
105Small cell lung cancer_Homo sapiens_hsa052220.61075215
106GnRH signaling pathway_Homo sapiens_hsa049120.60879197
107Regulation of autophagy_Homo sapiens_hsa041400.60550640
108Basal transcription factors_Homo sapiens_hsa030220.59820523
109MAPK signaling pathway_Homo sapiens_hsa040100.59274225
110Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.57898482
111Calcium signaling pathway_Homo sapiens_hsa040200.56353495
112Phospholipase D signaling pathway_Homo sapiens_hsa040720.55638240
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.55101982
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.54965463
115Nicotine addiction_Homo sapiens_hsa050330.54831198
116T cell receptor signaling pathway_Homo sapiens_hsa046600.54721367
117Ovarian steroidogenesis_Homo sapiens_hsa049130.54690388
118Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.54627369
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.54618135
120Epstein-Barr virus infection_Homo sapiens_hsa051690.54168773
121Rap1 signaling pathway_Homo sapiens_hsa040150.53840942
122Apoptosis_Homo sapiens_hsa042100.51394787
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50641383
124Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50203407
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.48908014
126Salivary secretion_Homo sapiens_hsa049700.47941155
127Protein export_Homo sapiens_hsa030600.47337862
128Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.46398430
129Long-term potentiation_Homo sapiens_hsa047200.46275591
130Maturity onset diabetes of the young_Homo sapiens_hsa049500.46212494
131Thyroid cancer_Homo sapiens_hsa052160.44317865
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.43482573
133Chemokine signaling pathway_Homo sapiens_hsa040620.43099600
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.43056381
135Vibrio cholerae infection_Homo sapiens_hsa051100.43055321
136Systemic lupus erythematosus_Homo sapiens_hsa053220.43018263
137Long-term depression_Homo sapiens_hsa047300.42863129
138Base excision repair_Homo sapiens_hsa034100.42122579
139PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41742759
140Leukocyte transendothelial migration_Homo sapiens_hsa046700.41416786
141AMPK signaling pathway_Homo sapiens_hsa041520.41171753
142Inositol phosphate metabolism_Homo sapiens_hsa005620.39160610
143Peroxisome_Homo sapiens_hsa041460.36638571
144Renin secretion_Homo sapiens_hsa049240.36108353
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.31188732
146Butanoate metabolism_Homo sapiens_hsa006500.28113621
147Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.24698625

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »