NHLRC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.90161695
2antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.90161695
3regulation of DNA endoreduplication (GO:0032875)3.86011028
4folic acid-containing compound biosynthetic process (GO:0009396)3.77072338
5mitotic sister chromatid cohesion (GO:0007064)3.76707602
6antigen processing and presentation of endogenous antigen (GO:0019883)3.38529037
7interkinetic nuclear migration (GO:0022027)3.28987744
8antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.28768527
9microtubule anchoring (GO:0034453)3.27672658
10nuclear pore complex assembly (GO:0051292)3.24481377
11protein prenylation (GO:0018342)3.20211639
12prenylation (GO:0097354)3.20211639
13regulation of pigment cell differentiation (GO:0050932)3.06217051
14microtubule depolymerization (GO:0007019)3.02732418
15negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.95185868
16negative regulation of translation, ncRNA-mediated (GO:0040033)2.95185868
17regulation of translation, ncRNA-mediated (GO:0045974)2.95185868
18nuclear pore organization (GO:0006999)2.92933580
19positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.92145317
20adult heart development (GO:0007512)2.87336956
21presynaptic membrane assembly (GO:0097105)2.86351203
22regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.85402614
23establishment of protein localization to Golgi (GO:0072600)2.84432911
24regulation of centriole replication (GO:0046599)2.83897366
25nucleus localization (GO:0051647)2.80881321
26low-density lipoprotein particle clearance (GO:0034383)2.80804771
27cytoplasmic mRNA processing body assembly (GO:0033962)2.80343033
28regulation of sarcomere organization (GO:0060297)2.78701103
29neural tube formation (GO:0001841)2.78457989
30dorsal/ventral axis specification (GO:0009950)2.77627052
31protein K11-linked deubiquitination (GO:0035871)2.74223104
32regulation of interferon-beta biosynthetic process (GO:0045357)2.73251914
33resolution of meiotic recombination intermediates (GO:0000712)2.73126833
34attachment of spindle microtubules to kinetochore (GO:0008608)2.72222258
35limb development (GO:0060173)2.71455945
36appendage development (GO:0048736)2.71455945
37positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.71192508
38positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.71192508
39positive regulation of mitotic sister chromatid separation (GO:1901970)2.71192508
40epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.69185058
41regulation of acyl-CoA biosynthetic process (GO:0050812)2.67333165
42centriole replication (GO:0007099)2.66837860
43sister chromatid segregation (GO:0000819)2.66316172
44replication fork processing (GO:0031297)2.65044011
45hepatocyte apoptotic process (GO:0097284)2.64938698
46negative regulation of cytosolic calcium ion concentration (GO:0051481)2.62099457
47tetrahydrofolate metabolic process (GO:0046653)2.61456333
48pore complex assembly (GO:0046931)2.59812606
49regulation of interleukin-12 biosynthetic process (GO:0045075)2.57088729
50chromatin remodeling at centromere (GO:0031055)2.56735102
51kinetochore organization (GO:0051383)2.55862806
52cardiac muscle cell development (GO:0055013)2.55405736
53monoubiquitinated protein deubiquitination (GO:0035520)2.54462273
54pteridine-containing compound biosynthetic process (GO:0042559)2.53277868
55negative regulation of DNA-dependent DNA replication (GO:2000104)2.52893544
56positive regulation of developmental pigmentation (GO:0048087)2.52442333
57positive regulation of interferon-alpha production (GO:0032727)2.52438472
58NIK/NF-kappaB signaling (GO:0038061)2.51854537
59CENP-A containing nucleosome assembly (GO:0034080)2.51555448
60sister chromatid cohesion (GO:0007062)2.50968862
61fibroblast migration (GO:0010761)2.50504015
62meiotic chromosome segregation (GO:0045132)2.50430739
63DNA double-strand break processing (GO:0000729)2.50062803
64negative regulation of DNA recombination (GO:0045910)2.48855987
65folic acid metabolic process (GO:0046655)2.47377625
66reciprocal DNA recombination (GO:0035825)2.46645823
67reciprocal meiotic recombination (GO:0007131)2.46645823
68glycine metabolic process (GO:0006544)2.45338030
69regulation of centrosome duplication (GO:0010824)2.44800585
70erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.43903639
71L-phenylalanine metabolic process (GO:0006558)2.43903639
72non-recombinational repair (GO:0000726)2.43839234
73double-strand break repair via nonhomologous end joining (GO:0006303)2.43839234
74regulation of sister chromatid cohesion (GO:0007063)2.43442010
75positive regulation of gamma-delta T cell activation (GO:0046645)2.42769623
76protein targeting to Golgi (GO:0000042)2.42058466
77nonmotile primary cilium assembly (GO:0035058)2.40127432
78cardiac myofibril assembly (GO:0055003)2.40006105
79otic vesicle formation (GO:0030916)2.38846479
80atrial cardiac muscle cell action potential (GO:0086014)2.38640919
81response to pheromone (GO:0019236)2.38452324
82cardiac cell development (GO:0055006)2.38277342
83mitotic chromosome condensation (GO:0007076)2.37936053
84synapsis (GO:0007129)2.37762561
85regulation of sulfur metabolic process (GO:0042762)2.36874776
86cilium organization (GO:0044782)2.36774417
87embryonic foregut morphogenesis (GO:0048617)2.36677071
88microtubule organizing center organization (GO:0031023)2.36582060
89somatic hypermutation of immunoglobulin genes (GO:0016446)2.36526121
90somatic diversification of immune receptors via somatic mutation (GO:0002566)2.36526121
91regulation of interferon-alpha production (GO:0032647)2.35603341
92retrograde transport, vesicle recycling within Golgi (GO:0000301)2.35296545
93regulation of relaxation of muscle (GO:1901077)2.34957340
94erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.34826274
95L-phenylalanine catabolic process (GO:0006559)2.34826274
96cysteine metabolic process (GO:0006534)2.34711405
97myofibril assembly (GO:0030239)2.34255667
98cilium assembly (GO:0042384)2.34187535
99cellular response to virus (GO:0098586)2.33681951
100regulation of integrin activation (GO:0033623)2.33068655
101mitotic nuclear envelope disassembly (GO:0007077)2.32432817
102DNA unwinding involved in DNA replication (GO:0006268)2.32418428
103centrosome organization (GO:0051297)2.31523581
104regulation of centrosome cycle (GO:0046605)2.30914923
105protein localization to kinetochore (GO:0034501)2.30704238
106establishment of nucleus localization (GO:0040023)2.30543637
107recombinational repair (GO:0000725)2.28296331
108presynaptic membrane organization (GO:0097090)2.27934508
109double-strand break repair via homologous recombination (GO:0000724)2.27326040
110folic acid-containing compound metabolic process (GO:0006760)2.24436143
111microtubule polymerization or depolymerization (GO:0031109)2.24097086
112artery development (GO:0060840)2.24091037
113positive regulation of natural killer cell differentiation (GO:0032825)2.23746667
114photoreceptor cell maintenance (GO:0045494)2.23483865
115UDP-N-acetylglucosamine metabolic process (GO:0006047)2.23395441
116histone exchange (GO:0043486)2.22892298
117somite development (GO:0061053)2.22007996
118regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.19581611
119regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.19381657
120genitalia morphogenesis (GO:0035112)2.19347844
121regulation of coenzyme metabolic process (GO:0051196)2.19284974
122regulation of cofactor metabolic process (GO:0051193)2.19284974
123response to X-ray (GO:0010165)2.19004186
124regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.18873860
125protein localization to Golgi apparatus (GO:0034067)2.18103725
126negative regulation of fibrinolysis (GO:0051918)2.17799147
127regulation of hippo signaling (GO:0035330)2.17200932
128sulfur amino acid catabolic process (GO:0000098)2.17075750
129pyrimidine nucleobase catabolic process (GO:0006208)2.16932807
130nuclear envelope disassembly (GO:0051081)2.16731745
131membrane disassembly (GO:0030397)2.16731745
132protein K6-linked ubiquitination (GO:0085020)2.16619174
133limb bud formation (GO:0060174)2.16463274
134serine family amino acid biosynthetic process (GO:0009070)2.16295697
135embryonic retina morphogenesis in camera-type eye (GO:0060059)2.15766176
136regulation of hexokinase activity (GO:1903299)2.15649073
137regulation of glucokinase activity (GO:0033131)2.15649073
138kinetochore assembly (GO:0051382)2.15477859
139one-carbon metabolic process (GO:0006730)2.15248173
140establishment of endothelial barrier (GO:0061028)2.13062126
141regulation of translational fidelity (GO:0006450)2.10962345
142regulation of cholesterol homeostasis (GO:2000188)2.09934735
143plasma lipoprotein particle clearance (GO:0034381)2.09892897
144triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.09437575
145T cell apoptotic process (GO:0070231)2.07843687
146urea cycle (GO:0000050)2.05015842
147urea metabolic process (GO:0019627)2.05015842
148antigen processing and presentation via MHC class Ib (GO:0002475)2.05003081
149positive regulation of B cell differentiation (GO:0045579)2.04513742
150alpha-linolenic acid metabolic process (GO:0036109)2.02778966
151regulation of gamma-delta T cell differentiation (GO:0045586)2.02237493
152peptidyl-glutamic acid carboxylation (GO:0017187)2.02113713
153protein carboxylation (GO:0018214)2.02113713
154regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.01987912
155regulation of protein activation cascade (GO:2000257)2.01313904
156pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.01301805
157protein autoprocessing (GO:0016540)2.00132757
158pentose-phosphate shunt (GO:0006098)1.99441549
159lysine metabolic process (GO:0006553)1.99261034
160lysine catabolic process (GO:0006554)1.99261034
161plasma lipoprotein particle assembly (GO:0034377)1.98846635
162regulation of triglyceride catabolic process (GO:0010896)1.98362279
163protein-lipid complex assembly (GO:0065005)1.97563507
164UMP metabolic process (GO:0046049)1.96084247
165pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)1.96084247
166UMP biosynthetic process (GO:0006222)1.96084247
167pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)1.96084247
168phospholipid homeostasis (GO:0055091)1.95505694
169lymphocyte apoptotic process (GO:0070227)1.95136144
170regulation of complement activation (GO:0030449)1.94513690
171regulation of gamma-delta T cell activation (GO:0046643)1.94453040
172DNA replication-dependent nucleosome assembly (GO:0006335)1.94195991
173DNA replication-dependent nucleosome organization (GO:0034723)1.94195991
174leukocyte apoptotic process (GO:0071887)1.94191739
175pteridine-containing compound metabolic process (GO:0042558)1.94123083
176positive regulation of interferon-beta production (GO:0032728)1.93549132
177protein localization to chromosome, centromeric region (GO:0071459)1.93317968
178regulation of response to tumor cell (GO:0002834)1.93264022
179positive regulation of response to tumor cell (GO:0002836)1.93264022
180positive regulation of immune response to tumor cell (GO:0002839)1.93264022
181regulation of immune response to tumor cell (GO:0002837)1.93264022
182serine family amino acid metabolic process (GO:0009069)1.92769680
183renal filtration (GO:0097205)1.92359386
184organ regeneration (GO:0031100)1.91809174
185nucleoside salvage (GO:0043174)1.90455277
186regulation of spindle organization (GO:0090224)1.90335157
187regulation of RIG-I signaling pathway (GO:0039535)1.90043988
188negative regulation of sterol transport (GO:0032372)1.89863219
189negative regulation of cholesterol transport (GO:0032375)1.89863219
190ethanol oxidation (GO:0006069)1.89237531
191positive regulation of heterotypic cell-cell adhesion (GO:0034116)1.89151490
192negative regulation of fatty acid biosynthetic process (GO:0045717)1.88792380
193growth hormone receptor signaling pathway (GO:0060396)1.88590016
194intestinal cholesterol absorption (GO:0030299)1.88456403
1953-UTR-mediated mRNA stabilization (GO:0070935)1.88216848
196AMP metabolic process (GO:0046033)1.88176466
197NADPH regeneration (GO:0006740)1.88111680
198positive regulation of protein oligomerization (GO:0032461)1.86898173

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.41364318
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.48177631
3SALL1_21062744_ChIP-ChIP_HESCs_Human3.46483089
4* POU3F2_20337985_ChIP-ChIP_501MEL_Human3.10164326
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse3.04598045
6GBX2_23144817_ChIP-Seq_PC3_Human2.91711565
7FOXM1_23109430_ChIP-Seq_U2OS_Human2.88365616
8FUS_26573619_Chip-Seq_HEK293_Human2.83539946
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.74819494
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.70658189
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.69300134
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.65810393
13IGF1R_20145208_ChIP-Seq_DFB_Human2.63763916
14FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.62610427
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.57381177
16EWS_26573619_Chip-Seq_HEK293_Human2.53067522
17TAF15_26573619_Chip-Seq_HEK293_Human2.52057531
18IRF8_22096565_ChIP-ChIP_GC-B_Human2.46453874
19PPARA_22158963_ChIP-Seq_LIVER_Mouse2.33310182
20RXR_22158963_ChIP-Seq_LIVER_Mouse2.29179569
21TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.26090346
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.25461297
23AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.22619243
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.18475365
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.15848690
26ZNF274_21170338_ChIP-Seq_K562_Hela2.10298970
27FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.10254540
28E2F4_17652178_ChIP-ChIP_JURKAT_Human2.07264030
29GATA1_22025678_ChIP-Seq_K562_Human2.06850527
30P300_19829295_ChIP-Seq_ESCs_Human2.06813612
31* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.06388064
32PIAS1_25552417_ChIP-Seq_VCAP_Human2.03951692
33PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.03317682
34AR_21909140_ChIP-Seq_LNCAP_Human2.00252236
35MYC_22102868_ChIP-Seq_BL_Human1.99232538
36VDR_22108803_ChIP-Seq_LS180_Human1.97613451
37EGR1_23403033_ChIP-Seq_LIVER_Mouse1.97000348
38* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.93103000
39RBPJ_22232070_ChIP-Seq_NCS_Mouse1.90208497
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.86540978
41LXR_22158963_ChIP-Seq_LIVER_Mouse1.85843210
42MYC_18555785_ChIP-Seq_MESCs_Mouse1.85397726
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.84705615
44SMAD4_21799915_ChIP-Seq_A2780_Human1.83631270
45FLI1_27457419_Chip-Seq_LIVER_Mouse1.78078695
46CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.77821058
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.77575082
48KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.74952532
49STAT3_23295773_ChIP-Seq_U87_Human1.73323497
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.72448447
51CLOCK_20551151_ChIP-Seq_293T_Human1.70754714
52PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.69483245
53* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.68574341
54ER_23166858_ChIP-Seq_MCF-7_Human1.64546835
55OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.64331550
56IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.64039094
57ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.61209134
58TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.61054799
59* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.57071230
60SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57027796
61CDX2_19796622_ChIP-Seq_MESCs_Mouse1.55518226
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.53221592
63IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.51372227
64NR3C1_21868756_ChIP-Seq_MCF10A_Human1.50852979
65TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50712323
66VDR_21846776_ChIP-Seq_THP-1_Human1.50397621
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.50351225
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49707429
69* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.49632156
70TCF4_23295773_ChIP-Seq_U87_Human1.49566269
71EZH2_27294783_Chip-Seq_NPCs_Mouse1.47265219
72FOXM1_26456572_ChIP-Seq_MCF-7_Human1.46096508
73MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.46087940
74STAT3_1855785_ChIP-Seq_MESCs_Mouse1.45484091
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.45346264
76STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.45035387
77PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44853848
78NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.44712886
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.44679249
80NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43037680
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.42785996
82BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42641803
83TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42545512
84NANOG_18555785_Chip-Seq_ESCs_Mouse1.39846621
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.38323629
86RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.38116629
87AR_21572438_ChIP-Seq_LNCaP_Human1.37700182
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.37616471
89RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.36797158
90AR_25329375_ChIP-Seq_VCAP_Human1.36514347
91CBP_20019798_ChIP-Seq_JUKART_Human1.36119069
92IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36119069
93TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35193577
94SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.33215159
95E2F1_21310950_ChIP-Seq_MCF-7_Human1.30803981
96NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29776742
97ZNF217_24962896_ChIP-Seq_MCF-7_Human1.29759779
98STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.29734418
99SUZ12_27294783_Chip-Seq_NPCs_Mouse1.29019714
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27947229
101EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.27354273
102KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26759448
103CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.26742237
104BCAT_22108803_ChIP-Seq_LS180_Human1.25753006
105MYB_26560356_Chip-Seq_TH1_Human1.25332754
106HIF1A_21447827_ChIP-Seq_MCF-7_Human1.25234147
107* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.24948713
108PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24710904
109HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.24563877
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24106752
111POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24106752
112MAF_26560356_Chip-Seq_TH1_Human1.23772481
113TP53_16413492_ChIP-PET_HCT116_Human1.22872037
114MYB_26560356_Chip-Seq_TH2_Human1.22644962
115TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22238538
116EZH2_22144423_ChIP-Seq_EOC_Human1.21051626
117E2F1_18555785_Chip-Seq_ESCs_Mouse1.19967572
118RUNX2_22187159_ChIP-Seq_PCA_Human1.19412273
119POU5F1_16153702_ChIP-ChIP_HESCs_Human1.16984462
120TCF4_22108803_ChIP-Seq_LS180_Human1.16732115
121FLI1_21867929_ChIP-Seq_TH2_Mouse1.16538063
122EP300_21415370_ChIP-Seq_HL-1_Mouse1.16451745
123ZNF263_19887448_ChIP-Seq_K562_Human1.15826047
124P53_22387025_ChIP-Seq_ESCs_Mouse1.15700009
125FOXO3_23340844_ChIP-Seq_DLD1_Human1.14359692
126ARNT_22903824_ChIP-Seq_MCF-7_Human1.14271719
127SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13974553
128CDX2_22108803_ChIP-Seq_LS180_Human1.13676965
129NFE2_27457419_Chip-Seq_LIVER_Mouse1.13433322
130ELK3_25401928_ChIP-Seq_HUVEC_Human1.13290015
131SCL_19346495_ChIP-Seq_HPC-7_Human1.13200171
132TCF7_22412390_ChIP-Seq_EML_Mouse1.13149985
133IRF8_21731497_ChIP-ChIP_J774_Mouse1.12768924
134AHR_22903824_ChIP-Seq_MCF-7_Human1.12136889
135RNF2_27304074_Chip-Seq_NSC_Mouse1.12074843
136MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.12050266
137* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.11124928
138SOX2_21211035_ChIP-Seq_LN229_Gbm1.11098966
139GATA2_22383799_ChIP-Seq_G1ME_Mouse1.10844094
140STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.10237677
141KLF5_20875108_ChIP-Seq_MESCs_Mouse1.09974532
142RARG_19884340_ChIP-ChIP_MEFs_Mouse1.09772045
143TFEB_21752829_ChIP-Seq_HELA_Human1.09707465
144TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09144885
145TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08919834
146TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.08871796
147GATA6_25053715_ChIP-Seq_YYC3_Human1.08840327
148CRX_20693478_ChIP-Seq_RETINA_Mouse1.08593750
149SOX9_26525672_Chip-Seq_HEART_Mouse1.07509806
150CBX2_27304074_Chip-Seq_ESCs_Mouse1.07300050
151* IRF8_27001747_Chip-Seq_BMDM_Mouse1.07090516
152SPI1_23547873_ChIP-Seq_NB4_Human1.06684911
153MYC_19079543_ChIP-ChIP_MESCs_Mouse1.06604751
154NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.06088173
155NRF2_20460467_ChIP-Seq_MEFs_Mouse1.06088173
156* UTX_26944678_Chip-Seq_JUKART_Human1.05880845
157CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.05794266
158ATF3_27146783_Chip-Seq_COLON_Human1.05569675
159* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05448649
160STAT4_19710469_ChIP-ChIP_TH1__Mouse1.05278365
161KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04927074
162VDR_24763502_ChIP-Seq_THP-1_Human1.04755015
163POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.04685510
164STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.04635812
165* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.04388070
166* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.04388070
167TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.03739317
168* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03731310
169TBL1_22424771_ChIP-Seq_293T_Human1.03673008
170CMYC_18555785_Chip-Seq_ESCs_Mouse1.03663529
171GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02726313
172SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02678488
173* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.02293276
174* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.02119631
175PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01936360
176PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.01865789
177OCT4_21477851_ChIP-Seq_ESCs_Mouse1.01858374
178SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00143686
179FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.99229991
180ELF1_17652178_ChIP-ChIP_JURKAT_Human0.98607282
181SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98469086
182E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98134641
183* DCP1A_22483619_ChIP-Seq_HELA_Human0.96979466
184VDR_23849224_ChIP-Seq_CD4+_Human0.96510758
185KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96251304
186ELK1_19687146_ChIP-ChIP_HELA_Human0.95777837
187RUNX1_22412390_ChIP-Seq_EML_Mouse0.95421723
188XRN2_22483619_ChIP-Seq_HELA_Human0.94972746
189CHD1_26751641_Chip-Seq_LNCaP_Human0.94948749
190MYC_18358816_ChIP-ChIP_MESCs_Mouse0.94898683
191PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.93724257
192HOXB4_20404135_ChIP-ChIP_EML_Mouse0.92768409
193ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.91039560
194GATA4_25053715_ChIP-Seq_YYC3_Human0.90979033
195NCOR1_26117541_ChIP-Seq_K562_Human0.90766041

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis2.50274606
2MP0004215_abnormal_myocardial_fiber2.37181269
3MP0003806_abnormal_nucleotide_metabolis2.36672353
4MP0003705_abnormal_hypodermis_morpholog2.32558598
5MP0003890_abnormal_embryonic-extraembry2.27342170
6MP0010352_gastrointestinal_tract_polyps2.18372793
7MP0003136_yellow_coat_color2.14441132
8MP0005187_abnormal_penis_morphology2.09836628
9MP0002139_abnormal_hepatobiliary_system2.09721481
10MP0002837_dystrophic_cardiac_calcinosis2.05830731
11MP0000569_abnormal_digit_pigmentation2.05417232
12MP0006292_abnormal_olfactory_placode2.01957685
13MP0004084_abnormal_cardiac_muscle2.01575935
14MP0002138_abnormal_hepatobiliary_system1.99136597
15MP0009697_abnormal_copulation1.98513763
16MP0003937_abnormal_limbs/digits/tail_de1.96774972
17MP0005365_abnormal_bile_salt1.95997421
18MP0006072_abnormal_retinal_apoptosis1.91135506
19MP0005085_abnormal_gallbladder_physiolo1.90418237
20MP0006054_spinal_hemorrhage1.84305587
21MP0002234_abnormal_pharynx_morphology1.83789261
22MP0005253_abnormal_eye_physiology1.82534732
23MP0003646_muscle_fatigue1.80472330
24MP0003300_gastrointestinal_ulcer1.79491652
25MP0001293_anophthalmia1.77838418
26MP0005083_abnormal_biliary_tract1.77539761
27MP0000685_abnormal_immune_system1.75036956
28MP0003252_abnormal_bile_duct1.74420734
29MP0008875_abnormal_xenobiotic_pharmacok1.74192604
30MP0008877_abnormal_DNA_methylation1.73281619
31MP0009840_abnormal_foam_cell1.72455138
32MP0002166_altered_tumor_susceptibility1.71552113
33MP0002938_white_spotting1.69041508
34MP0005076_abnormal_cell_differentiation1.68306302
35MP0003693_abnormal_embryo_hatching1.67367629
36MP0000383_abnormal_hair_follicle1.65836516
37MP0002877_abnormal_melanocyte_morpholog1.59563752
38MP0010234_abnormal_vibrissa_follicle1.54246488
39MP0002102_abnormal_ear_morphology1.52529550
40MP0002396_abnormal_hematopoietic_system1.52262577
41MP0000631_abnormal_neuroendocrine_gland1.47362866
42MP0003436_decreased_susceptibility_to1.45345080
43MP0001984_abnormal_olfaction1.44713229
44MP0004145_abnormal_muscle_electrophysio1.43854714
45MP0003566_abnormal_cell_adhesion1.43352476
46MP0005397_hematopoietic_system_phenotyp1.42003583
47MP0001545_abnormal_hematopoietic_system1.42003583
48MP0008058_abnormal_DNA_repair1.39140845
49MP0005248_abnormal_Harderian_gland1.38658121
50MP0008438_abnormal_cutaneous_collagen1.38550879
51MP0003567_abnormal_fetal_cardiomyocyte1.36383406
52MP0004957_abnormal_blastocyst_morpholog1.36197934
53MP0004484_altered_response_of1.35585595
54MP0001835_abnormal_antigen_presentation1.34064248
55MP0010678_abnormal_skin_adnexa1.33781322
56MP0002638_abnormal_pupillary_reflex1.31922430
57MP0001286_abnormal_eye_development1.31539410
58MP0002006_tumorigenesis1.29786782
59MP0004808_abnormal_hematopoietic_stem1.28618574
60MP0005551_abnormal_eye_electrophysiolog1.28612697
61MP0003191_abnormal_cellular_cholesterol1.28368847
62MP0000778_abnormal_nervous_system1.28294891
63MP0003121_genomic_imprinting1.27242773
64MP0005171_absent_coat_pigmentation1.27238627
65MP0004947_skin_inflammation1.26811690
66MP0004185_abnormal_adipocyte_glucose1.26555574
67MP0003950_abnormal_plasma_membrane1.26549772
68MP0000609_abnormal_liver_physiology1.24055590
69MP0003077_abnormal_cell_cycle1.24052414
70MP0000427_abnormal_hair_cycle1.23529117
71MP0010307_abnormal_tumor_latency1.23072965
72MP0003656_abnormal_erythrocyte_physiolo1.22380725
73MP0005023_abnormal_wound_healing1.21752617
74MP0003718_maternal_effect1.21693510
75MP0005391_vision/eye_phenotype1.21648071
76MP0002697_abnormal_eye_size1.20000065
77MP0001666_abnormal_nutrient_absorption1.17464446
78MP0002233_abnormal_nose_morphology1.15706723
79MP0004036_abnormal_muscle_relaxation1.15009643
80MP0002254_reproductive_system_inflammat1.13029979
81MP0004147_increased_porphyrin_level1.12265016
82MP0008775_abnormal_heart_ventricle1.12003868
83MP0001873_stomach_inflammation1.08564341
84MP0000647_abnormal_sebaceous_gland1.08203412
85MP0004085_abnormal_heartbeat1.06638010
86MP0003453_abnormal_keratinocyte_physiol1.05712036
87MP0003111_abnormal_nucleus_morphology1.02449970
88MP0000465_gastrointestinal_hemorrhage1.02359605
89MP0004043_abnormal_pH_regulation1.01908267
90MP0009384_cardiac_valve_regurgitation1.01639057
91MP0003303_peritoneal_inflammation1.00892311
92MP0003755_abnormal_palate_morphology1.00355521
93MP0009780_abnormal_chondrocyte_physiolo1.00334155
94MP0010094_abnormal_chromosome_stability1.00321096
95MP0005174_abnormal_tail_pigmentation0.99583784
96MP0002160_abnormal_reproductive_system0.99392532
97MP0001485_abnormal_pinna_reflex0.98780776
98MP0001730_embryonic_growth_arrest0.98246034
99MP0009785_altered_susceptibility_to0.98118939
100MP0000767_abnormal_smooth_muscle0.98040297
101MP0001790_abnormal_immune_system0.97628450
102MP0005387_immune_system_phenotype0.97628450
103MP0010155_abnormal_intestine_physiology0.97561935
104MP0005025_abnormal_response_to0.97381734
105MP0010329_abnormal_lipoprotein_level0.96512971
106MP0001800_abnormal_humoral_immune0.96416746
107MP0003195_calcinosis0.96275718
108MP0000598_abnormal_liver_morphology0.95897736
109MP0002127_abnormal_cardiovascular_syste0.95609249
110MP0000350_abnormal_cell_proliferation0.95367588
111MP0009278_abnormal_bone_marrow0.94976154
112MP0003724_increased_susceptibility_to0.93902008
113MP0001529_abnormal_vocalization0.93683036
114MP0002084_abnormal_developmental_patter0.93557084
115MP0000490_abnormal_crypts_of0.93345764
116MP0005646_abnormal_pituitary_gland0.93099414
117MP0005620_abnormal_muscle_contractility0.92990854
118MP0002452_abnormal_antigen_presenting0.92899153
119MP0002060_abnormal_skin_morphology0.92773027
120MP0003935_abnormal_craniofacial_develop0.92257718
121MP0001299_abnormal_eye_distance/0.92190129
122MP0000428_abnormal_craniofacial_morphol0.91324662
123MP0008057_abnormal_DNA_replication0.90711698
124MP0002751_abnormal_autonomic_nervous0.89885115
125MP0001879_abnormal_lymphatic_vessel0.88928155
126MP0002398_abnormal_bone_marrow0.88730739
127MP0003868_abnormal_feces_composition0.88702364
128MP0010368_abnormal_lymphatic_system0.88516387
129MP0002723_abnormal_immune_serum0.88357152
130MP0003091_abnormal_cell_migration0.88265862
131MP0005275_abnormal_skin_tensile0.87935240
132MP0005408_hypopigmentation0.87783737
133MP0001915_intracranial_hemorrhage0.87422653
134MP0009703_decreased_birth_body0.87197382
135MP0001853_heart_inflammation0.86807420
136MP0000516_abnormal_urinary_system0.86240814
137MP0005367_renal/urinary_system_phenotyp0.86240814
138MP0003828_pulmonary_edema0.85922489
139MP0001243_abnormal_dermal_layer0.85885798
140MP0002088_abnormal_embryonic_growth/wei0.85658179
141MP0003119_abnormal_digestive_system0.85656498
142MP0004197_abnormal_fetal_growth/weight/0.85637736
143MP0003984_embryonic_growth_retardation0.85256577
144MP0002086_abnormal_extraembryonic_tissu0.84472417
145MP0005464_abnormal_platelet_physiology0.84137756
146MP0002419_abnormal_innate_immunity0.83983838
147MP0002092_abnormal_eye_morphology0.82810957
148MP0004134_abnormal_chest_morphology0.82700364
149MP0002009_preneoplasia0.82529958
150MP0009046_muscle_twitch0.82461335
151MP0005000_abnormal_immune_tolerance0.82395476
152MP0005319_abnormal_enzyme/_coenzyme0.82165600
153MP0009763_increased_sensitivity_to0.81972089
154MP0005666_abnormal_adipose_tissue0.81949664
155MP0003137_abnormal_impulse_conducting0.81208175
156MP0000372_irregular_coat_pigmentation0.81102967
157MP0008469_abnormal_protein_level0.81048027
158MP0004924_abnormal_behavior0.80823632
159MP0005386_behavior/neurological_phenoty0.80823632
160MP0002972_abnormal_cardiac_muscle0.80129543
161MP0003122_maternal_imprinting0.79880684
162MP0006276_abnormal_autonomic_nervous0.79380606
163MP0005195_abnormal_posterior_eye0.79326922
164MP0002269_muscular_atrophy0.79297005
165MP0002019_abnormal_tumor_incidence0.79154285
166MP0002722_abnormal_immune_system0.78782166
167MP0001486_abnormal_startle_reflex0.78223617
168MP0003787_abnormal_imprinting0.78169635
169MP0000689_abnormal_spleen_morphology0.77847924
170MP0005380_embryogenesis_phenotype0.77738521
171MP0001672_abnormal_embryogenesis/_devel0.77738521
172MP0000049_abnormal_middle_ear0.77554574
173MP0002420_abnormal_adaptive_immunity0.77551735
174MP0001845_abnormal_inflammatory_respons0.77518170
175MP0000858_altered_metastatic_potential0.77403913
176MP0003941_abnormal_skin_development0.77375396
177MP0003186_abnormal_redox_activity0.77327546
178MP0003861_abnormal_nervous_system0.77297326
179MP0001216_abnormal_epidermal_layer0.77289077
180MP0001819_abnormal_immune_cell0.77257927
181MP0001661_extended_life_span0.76656047
182MP0002405_respiratory_system_inflammati0.76469317
183MP0002095_abnormal_skin_pigmentation0.76394748
184MP0001324_abnormal_eye_pigmentation0.76078845
185MP0002429_abnormal_blood_cell0.76049225
186MP0000013_abnormal_adipose_tissue0.75982992
187MP0005385_cardiovascular_system_phenoty0.75618821
188MP0001544_abnormal_cardiovascular_syste0.75618821
189MP0003385_abnormal_body_wall0.75259851
190MP0002106_abnormal_muscle_physiology0.74976887
191MP0006138_congestive_heart_failure0.74967488
192MP0002928_abnormal_bile_duct0.74067606
193MP0008932_abnormal_embryonic_tissue0.72294091

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)3.53136091
2Volvulus (HP:0002580)3.40526453
3Polycythemia (HP:0001901)3.34753596
4Abnormality of monocarboxylic acid metabolism (HP:0010996)3.24782994
5Osteolytic defects of the phalanges of the hand (HP:0009771)3.18331237
6Osteolytic defects of the hand bones (HP:0009699)3.18331237
7Deep venous thrombosis (HP:0002625)3.17698188
8Xanthomatosis (HP:0000991)3.03790936
9Myocardial infarction (HP:0001658)3.01788585
10Abnormality of aromatic amino acid family metabolism (HP:0004338)2.92394502
11Pancreatic cysts (HP:0001737)2.87771856
12True hermaphroditism (HP:0010459)2.85075953
13Pancreatic fibrosis (HP:0100732)2.82378625
14Hyperventilation (HP:0002883)2.81757860
15Esophageal varix (HP:0002040)2.74839886
16Papillary thyroid carcinoma (HP:0002895)2.69836029
17Chronic hepatic failure (HP:0100626)2.69783437
18Hypobetalipoproteinemia (HP:0003563)2.67029537
19Acanthocytosis (HP:0001927)2.66873191
20Hematochezia (HP:0002573)2.66434773
21Chromsome breakage (HP:0040012)2.63940995
22Abnormality of the renal cortex (HP:0011035)2.59175425
23Colon cancer (HP:0003003)2.59048347
24Increased mean platelet volume (HP:0011877)2.55314813
25Chromosomal breakage induced by crosslinking agents (HP:0003221)2.54957641
26Autoimmune thrombocytopenia (HP:0001973)2.54364015
27Hypoglycemic coma (HP:0001325)2.53186077
28Nephronophthisis (HP:0000090)2.52717525
29Intestinal atresia (HP:0011100)2.51941370
30Abnormality of the common coagulation pathway (HP:0010990)2.51034075
31Aplasia/Hypoplasia of the tibia (HP:0005772)2.48840305
32Renal cortical cysts (HP:0000803)2.48605723
33Ankle contracture (HP:0006466)2.46054796
34Calf muscle hypertrophy (HP:0008981)2.42918315
35Drooling (HP:0002307)2.42026076
36Medial flaring of the eyebrow (HP:0010747)2.38806434
37Abnormality of the renal medulla (HP:0100957)2.37377299
38Thrombocytosis (HP:0001894)2.37081980
39Recurrent viral infections (HP:0004429)2.36156654
40Abnormal platelet volume (HP:0011876)2.35559942
41Abnormality of the astrocytes (HP:0100707)2.34052220
42Astrocytoma (HP:0009592)2.34052220
43Tubulointerstitial nephritis (HP:0001970)2.33633353
44Abnormality of chromosome stability (HP:0003220)2.33154660
45Abnormality of midbrain morphology (HP:0002418)2.31301816
46Molar tooth sign on MRI (HP:0002419)2.31301816
47Spastic diplegia (HP:0001264)2.30731194
48Fair hair (HP:0002286)2.25729027
49Rectal prolapse (HP:0002035)2.23387697
50Poikilocytosis (HP:0004447)2.23283377
51Right ventricular cardiomyopathy (HP:0011663)2.20108915
52Oligodactyly (hands) (HP:0001180)2.19179555
53Glioma (HP:0009733)2.18344628
54Muscle hypertrophy of the lower extremities (HP:0008968)2.18342642
55Hypolipoproteinemia (HP:0010981)2.18077468
56Abnormality of sulfur amino acid metabolism (HP:0004339)2.17917153
57Genetic anticipation (HP:0003743)2.15025778
58Aortic aneurysm (HP:0004942)2.15013017
59Genital tract atresia (HP:0001827)2.14509345
60Pheochromocytoma (HP:0002666)2.14492747
61Poor coordination (HP:0002370)2.13768689
62Abnormality of the intrinsic pathway (HP:0010989)2.13681006
63Increased serum ferritin (HP:0003281)2.09902464
64Excessive salivation (HP:0003781)2.09162794
65Gaze-evoked nystagmus (HP:0000640)2.09144395
66Abnormality of pyrimidine metabolism (HP:0004353)2.08737984
67Recurrent gram-negative bacterial infections (HP:0005420)2.08676180
68Abnormality of iron homeostasis (HP:0011031)2.07399914
69Chronic otitis media (HP:0000389)2.07306997
70Protrusio acetabuli (HP:0003179)2.07149214
71Congenital primary aphakia (HP:0007707)2.06571434
72Epidermoid cyst (HP:0200040)2.04641183
73Abnormality of methionine metabolism (HP:0010901)2.04486768
74Subaortic stenosis (HP:0001682)2.04018361
75Abnormality of the left ventricular outflow tract (HP:0011103)2.04018361
76Abnormality of the fingertips (HP:0001211)2.03758393
77Vaginal atresia (HP:0000148)2.02938385
78Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.02518205
79Thyroid carcinoma (HP:0002890)2.01995356
80Hepatocellular carcinoma (HP:0001402)2.00458930
81Abnormality of transition element cation homeostasis (HP:0011030)2.00398370
82Ependymoma (HP:0002888)1.99573922
83Hypercholesterolemia (HP:0003124)1.99433690
84Aplasia/Hypoplasia of the uvula (HP:0010293)1.99226592
85Recurrent fungal infections (HP:0002841)1.98566782
86Medulloblastoma (HP:0002885)1.98460582
87Hypoalphalipoproteinemia (HP:0003233)1.97232250
88Abnormality of glutamine family amino acid metabolism (HP:0010902)1.97154960
89Abnormality of the nasal mucosa (HP:0000433)1.96734067
90Fat malabsorption (HP:0002630)1.96621208
91Eczematoid dermatitis (HP:0000976)1.95989628
92Gait imbalance (HP:0002141)1.95882502
93Multiple enchondromatosis (HP:0005701)1.95000941
94Aplasia/Hypoplasia of the tongue (HP:0010295)1.94719333
95Ectopic kidney (HP:0000086)1.93804198
96Interstitial pulmonary disease (HP:0006530)1.92484954
97Abnormality of chromosome segregation (HP:0002916)1.91065042
98Short tibia (HP:0005736)1.90623513
99Biliary tract neoplasm (HP:0100574)1.90251721
100Peritonitis (HP:0002586)1.90215114
101Periodontitis (HP:0000704)1.89965204
102Vertebral compression fractures (HP:0002953)1.89224072
103Rhabdomyosarcoma (HP:0002859)1.89105089
104Postaxial foot polydactyly (HP:0001830)1.88993783
105Cerebral aneurysm (HP:0004944)1.88719200
106Ulnar bowing (HP:0003031)1.88333001
107Skin nodule (HP:0200036)1.88122303
108Meckel diverticulum (HP:0002245)1.86437756
109Colitis (HP:0002583)1.86225598
110Tubular atrophy (HP:0000092)1.85012507
111Abnormality of the ileum (HP:0001549)1.84956912
112Abnormal cartilage morphology (HP:0002763)1.84513259
113Long clavicles (HP:0000890)1.82204054
114Sloping forehead (HP:0000340)1.81634434
115Aneurysm (HP:0002617)1.81467226
116Abnormality of complement system (HP:0005339)1.81410464
117Abnormality of aspartate family amino acid metabolism (HP:0010899)1.81331538
118Abnormality of the ischium (HP:0003174)1.80585987
119Abnormal platelet function (HP:0011869)1.80163347
120Impaired platelet aggregation (HP:0003540)1.80163347
121Complement deficiency (HP:0004431)1.80037265
122Aplasia/Hypoplasia of the sternum (HP:0006714)1.79653225
123Spontaneous hematomas (HP:0007420)1.79484974
124Hyperammonemia (HP:0001987)1.79210378
125Abnormality of the vasculature of the conjunctiva (HP:0008054)1.78854314
126Truncal obesity (HP:0001956)1.78767596
127Abnormality of the calf musculature (HP:0001430)1.78049481
128Nephrogenic diabetes insipidus (HP:0009806)1.77737235
129Premature rupture of membranes (HP:0001788)1.76461697
130Hepatoblastoma (HP:0002884)1.76006296
131Radial bowing (HP:0002986)1.75428581
132Nonimmune hydrops fetalis (HP:0001790)1.75389471
133Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.74801650
134Abnormal lung lobation (HP:0002101)1.74516894
135Thrombophlebitis (HP:0004418)1.74489829
136Gingival bleeding (HP:0000225)1.74410063
137Optic nerve hypoplasia (HP:0000609)1.74289302
138Postaxial hand polydactyly (HP:0001162)1.74089447
139Abnormal biliary tract morphology (HP:0012440)1.73670243
140Conjunctival telangiectasia (HP:0000524)1.72917745
141Increased density of long bones (HP:0006392)1.72657518
142Acute myeloid leukemia (HP:0004808)1.72639504
143Hyperlipoproteinemia (HP:0010980)1.72036335
144Prolonged partial thromboplastin time (HP:0003645)1.71884155
145Recurrent bacterial skin infections (HP:0005406)1.71639014
146Abnormal hemoglobin (HP:0011902)1.71465839
147Partial agenesis of the corpus callosum (HP:0001338)1.71438351
148Neuroendocrine neoplasm (HP:0100634)1.71269500
149Nasal polyposis (HP:0100582)1.70574961
150Cystic hygroma (HP:0000476)1.70085218
151Aqueductal stenosis (HP:0002410)1.68835443
152Pustule (HP:0200039)1.68472994
153Broad-based gait (HP:0002136)1.68436547
154Small hand (HP:0200055)1.68092375
155Protruding tongue (HP:0010808)1.67481757
156Proximal tubulopathy (HP:0000114)1.67019496
157Nephroblastoma (Wilms tumor) (HP:0002667)1.66126644
158Biconcave vertebral bodies (HP:0004586)1.66031588
159Astigmatism (HP:0000483)1.65996200
160Reticulocytosis (HP:0001923)1.65984068
161Chorioretinal atrophy (HP:0000533)1.65562090
162Deviation of the thumb (HP:0009603)1.65435764
163Hypoplastic iliac wings (HP:0002866)1.65177032
164Increased connective tissue (HP:0009025)1.64899462
165Gonadotropin excess (HP:0000837)1.64637923
166Ketosis (HP:0001946)1.63892541
167Short foot (HP:0001773)1.63848221
168Epistaxis (HP:0000421)1.63567739
169Bundle branch block (HP:0011710)1.63425811
170Abnormality of reticulocytes (HP:0004312)1.63258987
171Bicuspid aortic valve (HP:0001647)1.63075024
172Cutaneous finger syndactyly (HP:0010554)1.63003765
173Gastrointestinal atresia (HP:0002589)1.62859969
174Abnormality of the nasal septum (HP:0000419)1.62238731
175Neoplasm of the oral cavity (HP:0100649)1.59914990
176Abnormality of proline metabolism (HP:0010907)1.59538493
177Hydroxyprolinuria (HP:0003080)1.59538493
178Proximal placement of thumb (HP:0009623)1.59036793
179Atrial fibrillation (HP:0005110)1.59003672
180Exotropia (HP:0000577)1.58947925
181Abnormality of macrophages (HP:0004311)1.58850214
182Abnormality of fatty-acid metabolism (HP:0004359)1.58427438
183Reticulocytopenia (HP:0001896)1.58414397
184Neoplasm of striated muscle (HP:0009728)1.58351597
185Bowed forearm bones (HP:0003956)1.57730648
186Bowing of the arm (HP:0006488)1.57730648
187Hypochromic anemia (HP:0001931)1.57624175
188Hypoplastic labia majora (HP:0000059)1.57354413
189Ileus (HP:0002595)1.57216625
190Embryonal renal neoplasm (HP:0011794)1.55294317
191Short 4th metacarpal (HP:0010044)1.55056365
192Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.55056365
193Cystic liver disease (HP:0006706)1.54238323
194Left ventricular hypertrophy (HP:0001712)1.54226478
195Congenital stationary night blindness (HP:0007642)1.54065660
196Preaxial hand polydactyly (HP:0001177)1.54054894
197Hyperalaninemia (HP:0003348)1.53486996
198Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.53486996

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK2.75097434
2STK102.68176424
3TBK12.41196042
4WNK32.28492979
5FLT32.27804893
6MKNK22.17936552
7BMPR1B2.16575284
8ACVR1B2.14589102
9OBSCN2.05534442
10TRIM282.05335342
11MAP3K42.02958227
12STK392.01707356
13TNIK2.01315000
14CDK121.98096794
15TTN1.96416379
16PKN21.93412315
17ERN11.91564729
18MAP3K101.88069248
19ERBB31.84760456
20EEF2K1.83303799
21SIK11.81892786
22AKT31.80760474
23RPS6KA41.80602288
24TYK21.78557661
25MKNK11.77246917
26LRRK21.73653476
27BCR1.70467427
28JAK31.66431212
29PTK61.63257107
30MST41.62440226
31TAOK31.60123104
32FRK1.60109622
33STK38L1.59222590
34MAP4K11.56329674
35IKBKB1.53251617
36MAP2K31.48463842
37MAP3K81.47533377
38TGFBR21.46470532
39PAK31.45765740
40MAP3K141.40841893
41IKBKE1.38145219
42RPS6KB21.37644905
43PNCK1.37263915
44STK41.36367014
45MAP4K21.36170094
46LATS11.35267481
47NEK21.32951932
48NME21.32579016
49WEE11.28647451
50MAP3K31.24933155
51SCYL21.20877031
52PINK11.18781317
53BCKDK1.18215884
54FGFR41.17382219
55MET1.16460580
56PLK41.15078587
57CAMK1G1.14148362
58NLK1.12868920
59CDC71.12604089
60BRSK21.12596601
61TRIB31.11877856
62CDK61.09453704
63CSNK1A1L1.09073731
64MAPK131.08564174
65CHUK1.07766373
66STK31.06887172
67CSF1R1.05844814
68PLK21.05758193
69PIM11.04776724
70ZAP701.00852013
71EPHA21.00714006
72PIM21.00154062
73NEK90.99450514
74SGK20.99309883
75CDK40.98256164
76TGFBR10.98214751
77PLK30.97124264
78EPHB10.96719424
79CSNK1G10.96701401
80GRK10.96246735
81OXSR10.94559762
82FER0.94409717
83WNK40.92985752
84DMPK0.92317040
85NEK10.92272994
86PIK3CA0.91439515
87JAK10.91372334
88CSK0.90968901
89TLK10.87916395
90CCNB10.87687201
91KDR0.87506347
92KIT0.86623139
93PRKCE0.86002162
94EIF2AK10.85672211
95STK240.82156652
96DYRK30.81928816
97MST1R0.78820851
98AURKB0.78809574
99MAP2K70.78335645
100FGFR20.77913782
101TAF10.77406347
102ATM0.76468209
103MAPKAPK30.75730677
104PLK10.75150198
105MELK0.74931477
106FGFR10.74854194
107PDGFRA0.71482062
108MTOR0.71218608
109CAMK1D0.70512754
110PAK40.70198188
111JAK20.70162502
112EPHA30.69936696
113CSNK1G20.69679384
114PAK20.69153044
115ITK0.68997837
116CDK30.67304338
117GRK60.66722311
118TESK20.66260786
119PBK0.65766424
120YES10.65571259
121INSRR0.65478268
122TEC0.65233377
123TTK0.65019693
124RPS6KA50.64522784
125BUB10.64248434
126PRKAA10.64246447
127CSNK1G30.63876092
128TRPM70.63208192
129BTK0.62862615
130CDK70.60512031
131LMTK20.59739230
132EIF2AK30.57757104
133ZAK0.55581130
134PDGFRB0.55428928
135PIK3CG0.54849932
136ABL20.54026498
137MARK10.53520833
138EIF2AK20.53072842
139FGFR30.52245907
140BRD40.52244387
141KSR10.51343608
142CAMK40.51290006
143NUAK10.51144127
144ADRBK20.50484326
145MAP3K110.50416400
146CHEK20.50369040
147MAPK110.50242811
148RIPK10.50011827
149MAPKAPK20.49504106
150VRK10.49287246
151PTK20.47815283
152TIE10.47493887
153EPHA40.47423650
154SRPK10.47226111
155ATR0.45725478
156SGK4940.45598096
157SGK2230.45598096
158DYRK1B0.44755322
159LCK0.44264851
160PRKAA20.43510382
161ERBB20.43417360
162SGK30.42614351
163NTRK30.42143187
164WNK10.40604918
165CHEK10.40575664
166PHKG20.40523584
167PHKG10.40523584
168CSNK1D0.39896109
169PRKACB0.38352939
170CDK10.38326720
171SGK10.37447711

Predicted pathways (KEGG)

RankGene SetZ-score
1Non-homologous end-joining_Homo sapiens_hsa034503.41768133
2Fanconi anemia pathway_Homo sapiens_hsa034602.44562981
3One carbon pool by folate_Homo sapiens_hsa006702.24293524
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.24195609
5Caffeine metabolism_Homo sapiens_hsa002322.11857431
6Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.03455367
7Selenocompound metabolism_Homo sapiens_hsa004501.91502538
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.91147763
9Primary bile acid biosynthesis_Homo sapiens_hsa001201.89818563
10DNA replication_Homo sapiens_hsa030301.82654828
11Folate biosynthesis_Homo sapiens_hsa007901.80993287
12Circadian rhythm_Homo sapiens_hsa047101.77763647
13Basal transcription factors_Homo sapiens_hsa030221.69257098
14Butanoate metabolism_Homo sapiens_hsa006501.67596953
15Nitrogen metabolism_Homo sapiens_hsa009101.67467252
16Systemic lupus erythematosus_Homo sapiens_hsa053221.66746044
17Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.66156728
18Fatty acid degradation_Homo sapiens_hsa000711.62492958
19Sulfur relay system_Homo sapiens_hsa041221.48940251
20Tryptophan metabolism_Homo sapiens_hsa003801.41278601
21Arginine biosynthesis_Homo sapiens_hsa002201.38055446
22Complement and coagulation cascades_Homo sapiens_hsa046101.36391840
23Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.35458807
24Protein export_Homo sapiens_hsa030601.33076176
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.32607389
26Sulfur metabolism_Homo sapiens_hsa009201.32582965
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.32474546
28Hedgehog signaling pathway_Homo sapiens_hsa043401.29744286
29Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.29703797
30Taste transduction_Homo sapiens_hsa047421.29636799
31Hippo signaling pathway_Homo sapiens_hsa043901.29407740
32TGF-beta signaling pathway_Homo sapiens_hsa043501.29378448
33Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.28560490
34Fatty acid biosynthesis_Homo sapiens_hsa000611.28543502
35Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.28062935
36Antigen processing and presentation_Homo sapiens_hsa046121.27420946
37p53 signaling pathway_Homo sapiens_hsa041151.27059292
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.25453392
39Small cell lung cancer_Homo sapiens_hsa052221.20653092
40NF-kappa B signaling pathway_Homo sapiens_hsa040641.19377533
41Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14801966
42Phototransduction_Homo sapiens_hsa047441.13696908
43Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.13467334
44Viral carcinogenesis_Homo sapiens_hsa052031.13107140
45Basal cell carcinoma_Homo sapiens_hsa052171.10104607
46Staphylococcus aureus infection_Homo sapiens_hsa051501.09402879
47Maturity onset diabetes of the young_Homo sapiens_hsa049501.08472873
48Steroid biosynthesis_Homo sapiens_hsa001001.08462482
49Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07517363
50Legionellosis_Homo sapiens_hsa051341.06962663
51Dilated cardiomyopathy_Homo sapiens_hsa054141.06686641
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.06151829
53Base excision repair_Homo sapiens_hsa034101.05293011
54Herpes simplex infection_Homo sapiens_hsa051681.04399236
55Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03946539
56Dorso-ventral axis formation_Homo sapiens_hsa043201.03159861
57Lysine degradation_Homo sapiens_hsa003101.02427253
58Cell cycle_Homo sapiens_hsa041101.01337363
59Leishmaniasis_Homo sapiens_hsa051400.98034632
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.98020233
61Insulin secretion_Homo sapiens_hsa049110.96569762
62Oocyte meiosis_Homo sapiens_hsa041140.94815517
63Histidine metabolism_Homo sapiens_hsa003400.94118665
64mRNA surveillance pathway_Homo sapiens_hsa030150.94052516
65Viral myocarditis_Homo sapiens_hsa054160.92278706
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.91206111
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.91165813
68Apoptosis_Homo sapiens_hsa042100.91163753
69Measles_Homo sapiens_hsa051620.90219871
70Linoleic acid metabolism_Homo sapiens_hsa005910.88493737
71Leukocyte transendothelial migration_Homo sapiens_hsa046700.88265715
72Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87688109
73PPAR signaling pathway_Homo sapiens_hsa033200.87075516
74Chemical carcinogenesis_Homo sapiens_hsa052040.85927597
75Renin-angiotensin system_Homo sapiens_hsa046140.85556578
76Nicotine addiction_Homo sapiens_hsa050330.85402379
77Tight junction_Homo sapiens_hsa045300.84963764
78Fat digestion and absorption_Homo sapiens_hsa049750.84569509
79Biosynthesis of amino acids_Homo sapiens_hsa012300.84364548
80Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.83857067
81Chronic myeloid leukemia_Homo sapiens_hsa052200.82765224
82Mismatch repair_Homo sapiens_hsa034300.82537017
83Cysteine and methionine metabolism_Homo sapiens_hsa002700.82354953
84ABC transporters_Homo sapiens_hsa020100.82242324
85Ribosome_Homo sapiens_hsa030100.81368188
86Peroxisome_Homo sapiens_hsa041460.81006743
87Carbon metabolism_Homo sapiens_hsa012000.80949206
882-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80326818
89Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.80251373
90Ether lipid metabolism_Homo sapiens_hsa005650.79812890
91Propanoate metabolism_Homo sapiens_hsa006400.79570519
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79485351
93Pentose phosphate pathway_Homo sapiens_hsa000300.79270876
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78678561
95MicroRNAs in cancer_Homo sapiens_hsa052060.78584775
96Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.77581055
97Toxoplasmosis_Homo sapiens_hsa051450.77136697
98Regulation of autophagy_Homo sapiens_hsa041400.77047399
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76442974
100Adherens junction_Homo sapiens_hsa045200.76178807
101NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75871184
102TNF signaling pathway_Homo sapiens_hsa046680.75863688
103Pertussis_Homo sapiens_hsa051330.75079864
104Acute myeloid leukemia_Homo sapiens_hsa052210.75009980
105Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74529033
106Steroid hormone biosynthesis_Homo sapiens_hsa001400.74287119
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.74083261
108Starch and sucrose metabolism_Homo sapiens_hsa005000.73101225
109RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.72425550
110Influenza A_Homo sapiens_hsa051640.72176873
111Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.72141259
112Pyruvate metabolism_Homo sapiens_hsa006200.71944754
113Wnt signaling pathway_Homo sapiens_hsa043100.71285584
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.71047319
115GABAergic synapse_Homo sapiens_hsa047270.68853669
116Retinol metabolism_Homo sapiens_hsa008300.67882820
117Glutamatergic synapse_Homo sapiens_hsa047240.67838191
118Fatty acid metabolism_Homo sapiens_hsa012120.67622575
119Malaria_Homo sapiens_hsa051440.67280085
120Pyrimidine metabolism_Homo sapiens_hsa002400.66953216
121Renin secretion_Homo sapiens_hsa049240.66230477
122Circadian entrainment_Homo sapiens_hsa047130.66198784
123Serotonergic synapse_Homo sapiens_hsa047260.65478867
124Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65070972
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.64756858
126Alcoholism_Homo sapiens_hsa050340.64393761
127Insulin resistance_Homo sapiens_hsa049310.64195692
128Hepatitis B_Homo sapiens_hsa051610.64177307
129RNA transport_Homo sapiens_hsa030130.64093077
130Osteoclast differentiation_Homo sapiens_hsa043800.64054418
131Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63913956
132Inositol phosphate metabolism_Homo sapiens_hsa005620.63809439
133Glutathione metabolism_Homo sapiens_hsa004800.62558459
134Bladder cancer_Homo sapiens_hsa052190.61787773
135Olfactory transduction_Homo sapiens_hsa047400.61406209
136Dopaminergic synapse_Homo sapiens_hsa047280.60745801
137beta-Alanine metabolism_Homo sapiens_hsa004100.60417376
138Long-term depression_Homo sapiens_hsa047300.59813722
139Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.59761140
140Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59201531
141Melanoma_Homo sapiens_hsa052180.59144078
142Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57572434
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57546413
144Glucagon signaling pathway_Homo sapiens_hsa049220.56851204
145Vascular smooth muscle contraction_Homo sapiens_hsa042700.56826891
146Hematopoietic cell lineage_Homo sapiens_hsa046400.56017547
147Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.55976512
148RNA degradation_Homo sapiens_hsa030180.55130295
149Morphine addiction_Homo sapiens_hsa050320.54817626
150Calcium signaling pathway_Homo sapiens_hsa040200.54141932
151Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54094782
152Primary immunodeficiency_Homo sapiens_hsa053400.54081577
153Pancreatic cancer_Homo sapiens_hsa052120.53526261
154Spliceosome_Homo sapiens_hsa030400.53475077
155Adipocytokine signaling pathway_Homo sapiens_hsa049200.53111602
156FoxO signaling pathway_Homo sapiens_hsa040680.52966137
157HTLV-I infection_Homo sapiens_hsa051660.52619397
158Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.52576642
159Shigellosis_Homo sapiens_hsa051310.52210332
160Homologous recombination_Homo sapiens_hsa034400.50985928
161Nucleotide excision repair_Homo sapiens_hsa034200.50390086
162B cell receptor signaling pathway_Homo sapiens_hsa046620.50340332
163Ovarian steroidogenesis_Homo sapiens_hsa049130.49636169
164RNA polymerase_Homo sapiens_hsa030200.49075032
165Purine metabolism_Homo sapiens_hsa002300.48531678
166Thyroid hormone synthesis_Homo sapiens_hsa049180.48253377

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