NHLRC4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)9.86685079
2doxorubicin metabolic process (GO:0044598)9.86685079
3daunorubicin metabolic process (GO:0044597)9.86685079
4axoneme assembly (GO:0035082)8.96496047
5left/right pattern formation (GO:0060972)8.42386753
6primary alcohol catabolic process (GO:0034310)7.18099358
7aminoglycoside antibiotic metabolic process (GO:0030647)6.48102213
8regulation of cilium movement (GO:0003352)6.46609602
9left/right axis specification (GO:0070986)6.43078284
10tolerance induction (GO:0002507)6.41900676
11vitamin transmembrane transport (GO:0035461)6.31339239
12ethanol metabolic process (GO:0006067)6.28940279
13ventricular system development (GO:0021591)6.22743039
14microtubule bundle formation (GO:0001578)5.64454251
15diterpenoid biosynthetic process (GO:0016102)5.55504978
16intraciliary transport (GO:0042073)5.51374790
17response to pheromone (GO:0019236)5.28185379
18response to xenobiotic stimulus (GO:0009410)5.18581601
19negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)5.01682054
20negative regulation of B cell mediated immunity (GO:0002713)4.89557781
21negative regulation of immunoglobulin mediated immune response (GO:0002890)4.89557781
22cilium organization (GO:0044782)4.87115894
23positive regulation of tolerance induction (GO:0002645)4.85998428
24regulation of germinal center formation (GO:0002634)4.81740566
25ethanol oxidation (GO:0006069)4.75164774
26cilium assembly (GO:0042384)4.74105570
27presynaptic membrane assembly (GO:0097105)4.73304790
28pyrimidine-containing compound transmembrane transport (GO:0072531)4.72637469
29sperm capacitation (GO:0048240)4.70123254
30lung epithelium development (GO:0060428)4.64296773
31centriole assembly (GO:0098534)4.55244262
32detection of molecule of bacterial origin (GO:0032490)4.48059353
33regulation of interleukin-5 production (GO:0032674)4.47624684
34negative regulation of humoral immune response (GO:0002921)4.47567798
35establishment of apical/basal cell polarity (GO:0035089)4.41438544
36presynaptic membrane organization (GO:0097090)4.36123123
37negative regulation of T cell differentiation in thymus (GO:0033085)4.27157399
38regulation of interleukin-13 production (GO:0032656)4.26899839
39regulation of tolerance induction (GO:0002643)4.01145221
40protein localization to cilium (GO:0061512)3.98235190
41glomerular epithelial cell development (GO:0072310)3.91513371
42sulfate transmembrane transport (GO:1902358)3.90029374
43microtubule-based movement (GO:0007018)3.87160883
44neuron remodeling (GO:0016322)3.82928351
45adenine nucleotide transport (GO:0051503)3.76740926
46purine ribonucleotide transport (GO:0015868)3.74659048
47establishment of monopolar cell polarity (GO:0061162)3.71391255
48establishment or maintenance of monopolar cell polarity (GO:0061339)3.71391255
49cytoplasmic microtubule organization (GO:0031122)3.70881567
50gas transport (GO:0015669)3.68239921
51cellular component assembly involved in morphogenesis (GO:0010927)3.67909766
52regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.63312824
53negative regulation of synaptic transmission, GABAergic (GO:0032229)3.63305078
54terpenoid biosynthetic process (GO:0016114)3.61377980
55regulation of microtubule-based movement (GO:0060632)3.61373843
56cellular anion homeostasis (GO:0030002)3.60628855
57regulation of response to osmotic stress (GO:0047484)3.58336167
58postsynaptic membrane organization (GO:0001941)3.52098377
59protoporphyrinogen IX metabolic process (GO:0046501)3.51753241
60cell projection assembly (GO:0030031)3.50546715
61auditory receptor cell stereocilium organization (GO:0060088)3.48691025
62retinoic acid metabolic process (GO:0042573)3.46524525
63inner ear receptor stereocilium organization (GO:0060122)3.43511902
64sulfate transport (GO:0008272)3.41662490
65negative regulation of inclusion body assembly (GO:0090084)3.36912447
66cerebral cortex radially oriented cell migration (GO:0021799)3.34862772
67bicarbonate transport (GO:0015701)3.31352026
68energy homeostasis (GO:0097009)3.26379556
69import into cell (GO:0098657)3.24781437
70central nervous system myelination (GO:0022010)3.24672962
71axon ensheathment in central nervous system (GO:0032291)3.24672962
72hydrogen peroxide biosynthetic process (GO:0050665)3.24248455
73long-chain fatty acid biosynthetic process (GO:0042759)3.23732780
74nucleoside diphosphate phosphorylation (GO:0006165)3.22255415
75opioid receptor signaling pathway (GO:0038003)3.20632941
76nucleotide transmembrane transport (GO:1901679)3.20291463
77negative regulation of macroautophagy (GO:0016242)3.19120405
78purine nucleotide transport (GO:0015865)3.18102663
79trivalent inorganic anion homeostasis (GO:0072506)3.17868645
80phosphate ion homeostasis (GO:0055062)3.17868645
81progesterone metabolic process (GO:0042448)3.11495493
82detection of external biotic stimulus (GO:0098581)3.09327445
83vitamin catabolic process (GO:0009111)3.07127557
84fat-soluble vitamin catabolic process (GO:0042363)3.07127557
85lateral sprouting from an epithelium (GO:0060601)3.06670884
86hypotonic response (GO:0006971)3.01040372
87axonemal dynein complex assembly (GO:0070286)20.4638406
88primary alcohol metabolic process (GO:0034308)2.98897611
89phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.98428024
90limb bud formation (GO:0060174)2.98066264
91cilium morphogenesis (GO:0060271)2.97916178
92microtubule depolymerization (GO:0007019)2.97655294
93protoporphyrinogen IX biosynthetic process (GO:0006782)2.96760106
94hydrogen peroxide catabolic process (GO:0042744)2.96428889
95reactive oxygen species biosynthetic process (GO:1903409)2.94828789
96O-glycan processing (GO:0016266)2.94689787
97positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.90515644
98regulation of timing of cell differentiation (GO:0048505)2.89979147
99exogenous drug catabolic process (GO:0042738)2.87103626
100extracellular negative regulation of signal transduction (GO:1900116)2.86487728
101extracellular regulation of signal transduction (GO:1900115)2.86487728
102atrial cardiac muscle cell action potential (GO:0086014)2.86389351
103positive regulation of uterine smooth muscle contraction (GO:0070474)2.85879143
104mesenchymal cell differentiation involved in renal system development (GO:2001012)2.85317281
105mesenchymal cell differentiation involved in kidney development (GO:0072161)2.85317281
106oxygen transport (GO:0015671)2.84801474
107positive regulation of action potential (GO:0045760)2.83123356
108regulation of microtubule depolymerization (GO:0031114)2.82238577
109prostate gland growth (GO:0060736)2.81428372
110glutathione derivative biosynthetic process (GO:1901687)2.81246851
111glutathione derivative metabolic process (GO:1901685)2.81246851
112G-protein coupled receptor internalization (GO:0002031)2.80844180
113drinking behavior (GO:0042756)2.80779835
114regulation of autophagic vacuole assembly (GO:2000785)2.79355689
115iron ion import (GO:0097286)2.79242858
116one-carbon compound transport (GO:0019755)2.78741658
117glycine transport (GO:0015816)2.77958598
118nucleotide transport (GO:0006862)2.77414386
119multicellular organismal water homeostasis (GO:0050891)2.75311565
120regulation of activation of Janus kinase activity (GO:0010533)2.75055994
121positive regulation of smoothened signaling pathway (GO:0045880)2.75023798
122negative regulation of stem cell proliferation (GO:2000647)2.72657454
123regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 2.72494643
124ionotropic glutamate receptor signaling pathway (GO:0035235)2.72378641
125phosphatidylcholine biosynthetic process (GO:0006656)2.72062084
126retinol metabolic process (GO:0042572)2.70771822
127regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.70382128
128aldehyde catabolic process (GO:0046185)2.69728436
129regulation of apoptotic cell clearance (GO:2000425)2.67489108
130regulation of pigment cell differentiation (GO:0050932)2.67386699
131negative regulation of adaptive immune response (GO:0002820)2.67164374
132regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.66914359
133microtubule polymerization or depolymerization (GO:0031109)2.66280925
134carnitine metabolic process (GO:0009437)2.64973255
135negative regulation of keratinocyte proliferation (GO:0010839)2.64714800
136L-amino acid import (GO:0043092)2.63634859
137neuron cell-cell adhesion (GO:0007158)2.63064316
138superoxide anion generation (GO:0042554)2.61433326
139phosphatidylethanolamine biosynthetic process (GO:0006646)2.61193530
140lipoxygenase pathway (GO:0019372)2.61013898
141detection of biotic stimulus (GO:0009595)2.60484607
142positive regulation of extracellular matrix organization (GO:1903055)2.59113257
143lateral ventricle development (GO:0021670)2.59008481
144regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.58205089
145regulation of fever generation (GO:0031620)2.57778703
146negative regulation of neurotransmitter transport (GO:0051589)2.56546384
147amino acid import (GO:0043090)2.56215221
148regulation of interleukin-4 production (GO:0032673)2.55669510
149forebrain neuron differentiation (GO:0021879)2.55245542
150negative regulation of lymphocyte mediated immunity (GO:0002707)2.54996120
151regulation of somitogenesis (GO:0014807)2.54304867
152hydrogen peroxide metabolic process (GO:0042743)2.54299058
153post-embryonic morphogenesis (GO:0009886)2.52520643
154establishment of tissue polarity (GO:0007164)2.52259890
155establishment of planar polarity (GO:0001736)2.52259890
156kidney morphogenesis (GO:0060993)2.52224304
157cell proliferation in forebrain (GO:0021846)2.50533113
158regulation of vacuole organization (GO:0044088)2.49722335
159vocalization behavior (GO:0071625)2.46019068
160cell differentiation involved in metanephros development (GO:0072202)2.46009861
161regulation of interleukin-6 biosynthetic process (GO:0045408)2.44412747
162positive regulation of neurotransmitter secretion (GO:0001956)2.43024664
163sperm motility (GO:0030317)2.42156260
164negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.41620295
165cranial nerve morphogenesis (GO:0021602)2.41465970
166estrogen biosynthetic process (GO:0006703)2.40510567
167calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.39982019
168oligosaccharide biosynthetic process (GO:0009312)2.39435822
169polyol transport (GO:0015791)2.38480924
170embryonic camera-type eye development (GO:0031076)2.35362054
171surfactant homeostasis (GO:0043129)2.35106561
172regulation of cilium assembly (GO:1902017)2.33793680
173negative regulation of toll-like receptor signaling pathway (GO:0034122)2.33503449
174negative regulation of response to extracellular stimulus (GO:0032105)2.33252762
175negative regulation of response to nutrient levels (GO:0032108)2.33252762
176regulation of development, heterochronic (GO:0040034)2.31471893
177sialylation (GO:0097503)2.31431566
178phosphatidylethanolamine metabolic process (GO:0046337)2.31169943
179negative regulation of myoblast differentiation (GO:0045662)2.31037282
180regulation of non-canonical Wnt signaling pathway (GO:2000050)2.29847441
181regulation of mitochondrial depolarization (GO:0051900)2.29581637
182G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.29473366
183tetrapyrrole biosynthetic process (GO:0033014)2.29330020
184positive regulation of synaptic transmission, GABAergic (GO:0032230)2.28773401
185glutamate receptor signaling pathway (GO:0007215)2.28343480
186mesenchymal-epithelial cell signaling (GO:0060638)2.26717464
187membrane assembly (GO:0071709)2.26107316
188negative regulation of erythrocyte differentiation (GO:0045647)2.25632166
189regulation of uterine smooth muscle contraction (GO:0070472)2.24462679
190regulation of heat generation (GO:0031650)2.21640009
191reflex (GO:0060004)2.19815571
192developmental pigmentation (GO:0048066)2.18707210
193cilium or flagellum-dependent cell motility (GO:0001539)16.8439028
194motile cilium assembly (GO:0044458)14.1465738
195cilium movement (GO:0003341)13.8116258
196epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)12.2241575
197epithelial cilium movement (GO:0003351)11.6869730

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.95238071
2EZH2_22144423_ChIP-Seq_EOC_Human4.21372870
3GBX2_23144817_ChIP-Seq_PC3_Human3.77332972
4GATA1_19941826_ChIP-Seq_K562_Human2.90777018
5BP1_19119308_ChIP-ChIP_Hs578T_Human2.74754761
6GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.45454352
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.44241407
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.40194484
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.37205066
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.36683776
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.33246832
12TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.33245011
13SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.31404277
14SMAD_19615063_ChIP-ChIP_OVARY_Human2.25891924
15ELF1_20517297_ChIP-Seq_JURKAT_Human2.25207770
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23807695
17EZH2_27304074_Chip-Seq_ESCs_Mouse2.18189696
18LXR_22292898_ChIP-Seq_THP-1_Human2.16616817
19SMC4_20622854_ChIP-Seq_HELA_Human2.11182432
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11057884
21SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.05361846
22IRF8_22096565_ChIP-ChIP_GC-B_Human2.05192767
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.01538276
24EZH2_18974828_ChIP-Seq_MESCs_Mouse2.01538276
25BMI1_23680149_ChIP-Seq_NPCS_Mouse2.01195790
26CBX2_27304074_Chip-Seq_ESCs_Mouse2.00683462
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.00316987
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.99716524
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.95143758
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.92236282
31VDR_21846776_ChIP-Seq_THP-1_Human1.89675799
32P68_20966046_ChIP-Seq_HELA_Human1.88164293
33RUNX1_27514584_Chip-Seq_MCF-7_Human1.86091421
34RACK7_27058665_Chip-Seq_MCF-7_Human1.85234254
35* RNF2_27304074_Chip-Seq_ESCs_Mouse1.83818095
36PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.83296662
37MAF_26560356_Chip-Seq_TH1_Human1.81526967
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.80896004
39PCGF2_27294783_Chip-Seq_ESCs_Mouse1.79836546
40P300_19829295_ChIP-Seq_ESCs_Human1.79465281
41AR_21572438_ChIP-Seq_LNCaP_Human1.79317139
42VDR_24763502_ChIP-Seq_THP-1_Human1.78882257
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.77492860
44POU3F2_20337985_ChIP-ChIP_501MEL_Human1.76347664
45VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.76247064
46CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.76220900
47NFE2_27457419_Chip-Seq_LIVER_Mouse1.75697417
48* STAT1_20625510_ChIP-Seq_HELA_Human1.75186695
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.74899910
50E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.74824084
51SOX2_27498859_Chip-Seq_STOMACH_Mouse1.74472976
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73654530
53PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.72417265
54GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.71242510
55SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.70860658
56GATA2_19941826_ChIP-Seq_K562_Human1.69543381
57TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.69137852
58KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.68697587
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.68391115
60CDX2_19796622_ChIP-Seq_MESCs_Mouse1.68161264
61* EZH2_27294783_Chip-Seq_ESCs_Mouse1.67608374
62* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.66930233
63PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.66117962
64YY1_22570637_ChIP-Seq_MALME-3M_Human1.65876201
65PCGF2_27294783_Chip-Seq_NPCs_Mouse1.65089153
66RNF2_27304074_Chip-Seq_NSC_Mouse1.65078400
67TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.63408904
68POU5F1_16153702_ChIP-ChIP_HESCs_Human1.62482746
69MTF2_20144788_ChIP-Seq_MESCs_Mouse1.60720255
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.60420745
71* TP63_22573176_ChIP-Seq_HFKS_Human1.60255892
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.59886744
73P63_26484246_Chip-Seq_KERATINOCYTES_Human1.59210186
74BCOR_27268052_Chip-Seq_Bcells_Human1.58190951
75EZH2_27294783_Chip-Seq_NPCs_Mouse1.58151158
76SA1_27219007_Chip-Seq_ERYTHROID_Human1.55905348
77NCOR1_26117541_ChIP-Seq_K562_Human1.55328372
78NANOG_18555785_Chip-Seq_ESCs_Mouse1.54165430
79CREB1_26743006_Chip-Seq_LNCaP_Human1.52203278
80SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.51699450
81TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51588086
82STAT6_21828071_ChIP-Seq_BEAS2B_Human1.51537743
83SMAD4_21799915_ChIP-Seq_A2780_Human1.51398451
84EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.50950177
85PHF8_20622854_ChIP-Seq_HELA_Human1.50740433
86ESR2_21235772_ChIP-Seq_MCF-7_Human1.50113635
87BCL6_27268052_Chip-Seq_Bcells_Human1.49474708
88E2F1_18555785_Chip-Seq_ESCs_Mouse1.48829811
89ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.48771184
90RUNX1_22412390_ChIP-Seq_EML_Mouse1.47918087
91IGF1R_20145208_ChIP-Seq_DFB_Human1.47302767
92VDR_22108803_ChIP-Seq_LS180_Human1.46669334
93CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45411469
94TAF15_26573619_Chip-Seq_HEK293_Human1.45358495
95SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.44489395
96FLI1_27457419_Chip-Seq_LIVER_Mouse1.44390721
97PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.44390066
98CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44360390
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.43076448
100POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.43076448
101UTX_26944678_Chip-Seq_JUKART_Human1.42210682
102CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.41575251
103TCF7_22412390_ChIP-Seq_EML_Mouse1.41490862
104KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.41295605
105STAT3_18555785_Chip-Seq_ESCs_Mouse1.40835908
106SPI1_23127762_ChIP-Seq_K562_Human1.40786092
107FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.40458936
108P53_22387025_ChIP-Seq_ESCs_Mouse1.40295788
109SUZ12_18555785_Chip-Seq_ESCs_Mouse1.39564517
110CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39022375
111KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.37607847
112BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35506576
113SMAD3_21741376_ChIP-Seq_EPCs_Human1.35010645
114ER_23166858_ChIP-Seq_MCF-7_Human1.34390611
115STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33024898
116RAD21_21589869_ChIP-Seq_MESCs_Mouse1.32961498
117ESR1_20079471_ChIP-ChIP_T-47D_Human1.32566554
118P300_27268052_Chip-Seq_Bcells_Human1.32165910
119CMYC_18555785_Chip-Seq_ESCs_Mouse1.31747440
120E2F1_20622854_ChIP-Seq_HELA_Human1.30352655
121TP53_18474530_ChIP-ChIP_U2OS_Human1.29874368
122STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.28957818
123CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28598288
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28360934
125NMYC_18555785_Chip-Seq_ESCs_Mouse1.27921147
126NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.27778228
127SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.27560967
128HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.27083947
129NR3C1_21868756_ChIP-Seq_MCF10A_Human1.26226352
130SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.25945164
131ELK3_25401928_ChIP-Seq_HUVEC_Human1.25216152
132CTCF_20526341_ChIP-Seq_ESCs_Human1.24770275
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24323695
134EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.24275179
135FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.23656073
136PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23407351
137FUS_26573619_Chip-Seq_HEK293_Human1.23040272
138P300_18555785_Chip-Seq_ESCs_Mouse1.22956739
139GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21852597
140KLF5_25053715_ChIP-Seq_YYC3_Human1.21630568
141CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.21587880
142RARG_19884340_ChIP-ChIP_MEFs_Mouse1.20126285
143* CTCF_27219007_Chip-Seq_Bcells_Human1.20028982
144DROSHA_22980978_ChIP-Seq_HELA_Human1.19665775
145VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.19626707
146OCT4_18555785_Chip-Seq_ESCs_Mouse1.19115099
147RUNX1_27457419_Chip-Seq_LIVER_Mouse1.18924373
148TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.18892828
149ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18753200
150TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18714522
151TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.18084097
152PU1_27457419_Chip-Seq_LIVER_Mouse1.17956017
153TP53_16413492_ChIP-PET_HCT116_Human1.17867827
154UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.17496065
155SOX2_18555785_Chip-Seq_ESCs_Mouse1.15166701
156ZFX_18555785_Chip-Seq_ESCs_Mouse1.14621711
157EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14388796
158LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14016804
159TDRD3_21172665_ChIP-Seq_MCF-7_Human1.13473536
160SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13392435
161REST_21632747_ChIP-Seq_MESCs_Mouse1.13029163
162ZNF263_19887448_ChIP-Seq_K562_Human1.11602622
163AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11311323
164CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11062470
165RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.10991064
166* KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.10845195
167MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09191232
168AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.08844210
169RARB_24833708_ChIP-Seq_LIVER_Mouse1.07774198
170SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07531557
171MAF_26560356_Chip-Seq_TH2_Human1.07475536
172TAL1_26923725_Chip-Seq_HPCs_Mouse1.07280003
173ESRRB_18555785_Chip-Seq_ESCs_Mouse1.06933223
174KDM2B_26808549_Chip-Seq_DND41_Human1.06357972
175CTBP1_25329375_ChIP-Seq_LNCAP_Human1.05996811
176RUNX2_22187159_ChIP-Seq_PCA_Human1.05763631
177KLF4_18555785_Chip-Seq_ESCs_Mouse1.05604398
178OCT4_21477851_ChIP-Seq_ESCs_Mouse1.05368963
179SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.05096167
180CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.04810981
181STAT3_1855785_ChIP-Seq_MESCs_Mouse1.04603020
182GATA3_27048872_Chip-Seq_THYMUS_Human1.04340449
183SOX9_24532713_ChIP-Seq_HFSC_Mouse1.04330196
184SCL_19346495_ChIP-Seq_HPC-7_Human1.03995265
185TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.03823046
186IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.03002532
187DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01752332
188PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01367512
189FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01294852
190IRF8_27001747_Chip-Seq_BMDM_Mouse1.00347747
191SMRT_27268052_Chip-Seq_Bcells_Human0.99175608
192P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.99062571
193MYC_22102868_ChIP-Seq_BL_Human0.98751240
194CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98241167
195CDX2_20551321_ChIP-Seq_CACO-2_Human0.97553439
196MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.97354534
197FOXA1_25552417_ChIP-Seq_VCAP_Human0.97148782

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008875_abnormal_xenobiotic_pharmacok5.85214207
2MP0002653_abnormal_ependyma_morphology5.79998629
3MP0005645_abnormal_hypothalamus_physiol4.18090004
4MP0002277_abnormal_respiratory_mucosa3.19123075
5MP0005171_absent_coat_pigmentation3.18371415
6MP0004043_abnormal_pH_regulation3.15430390
7MP0006292_abnormal_olfactory_placode3.12830822
8MP0000566_synostosis3.09209702
9MP0005646_abnormal_pituitary_gland2.98359000
10MP0004147_increased_porphyrin_level2.97079063
11MP0009697_abnormal_copulation2.88116873
12MP0005083_abnormal_biliary_tract2.85247286
13MP0003136_yellow_coat_color2.84052333
14MP0003303_peritoneal_inflammation2.73250993
15MP0003656_abnormal_erythrocyte_physiolo2.68590986
16MP0003880_abnormal_central_pattern2.67390573
17MP0004133_heterotaxia2.62738652
18MP0008004_abnormal_stomach_pH2.47081660
19MP0008789_abnormal_olfactory_epithelium2.40324882
20MP0005377_hearing/vestibular/ear_phenot2.36089489
21MP0003878_abnormal_ear_physiology2.36089489
22MP0005623_abnormal_meninges_morphology2.19732458
23MP0004782_abnormal_surfactant_physiolog2.11177953
24MP0004742_abnormal_vestibular_system2.04548580
25MP0001986_abnormal_taste_sensitivity2.04475043
26MP0010155_abnormal_intestine_physiology1.96550983
27MP0001188_hyperpigmentation1.95921879
28MP0005257_abnormal_intraocular_pressure1.92383415
29MP0001486_abnormal_startle_reflex1.92265747
30MP0002638_abnormal_pupillary_reflex1.90349232
31MP0009046_muscle_twitch1.79155808
32MP0000465_gastrointestinal_hemorrhage1.78556263
33MP0006276_abnormal_autonomic_nervous1.75709882
34MP0002249_abnormal_larynx_morphology1.75097976
35MP0001790_abnormal_immune_system1.71415680
36MP0005387_immune_system_phenotype1.71415680
37MP0002102_abnormal_ear_morphology1.70933946
38MP0000015_abnormal_ear_pigmentation1.70366719
39MP0002168_other_aberrant_phenotype1.70160164
40MP0009278_abnormal_bone_marrow1.67799294
41MP0000049_abnormal_middle_ear1.63875248
42MP0009745_abnormal_behavioral_response1.63486741
43MP0002405_respiratory_system_inflammati1.63410403
44MP0002938_white_spotting1.62340787
45MP0002132_abnormal_respiratory_system1.61639747
46MP0003191_abnormal_cellular_cholesterol1.61439599
47MP0001765_abnormal_ion_homeostasis1.59149203
48MP0001835_abnormal_antigen_presentation1.58859775
49MP0005394_taste/olfaction_phenotype1.58723444
50MP0005499_abnormal_olfactory_system1.58723444
51MP0003787_abnormal_imprinting1.56086879
52MP0004019_abnormal_vitamin_homeostasis1.55742923
53MP0001346_abnormal_lacrimal_gland1.55562117
54MP0005423_abnormal_somatic_nervous1.53404328
55MP0001968_abnormal_touch/_nociception1.52745076
56MP0001545_abnormal_hematopoietic_system1.51226914
57MP0005397_hematopoietic_system_phenotyp1.51226914
58MP0003941_abnormal_skin_development1.50235146
59MP0003436_decreased_susceptibility_to1.49928056
60MP0000678_abnormal_parathyroid_gland1.49370557
61MP0001529_abnormal_vocalization1.47983872
62MP0000681_abnormal_thyroid_gland1.46709895
63MP0005025_abnormal_response_to1.42813611
64MP0001485_abnormal_pinna_reflex1.41763642
65MP0005165_increased_susceptibility_to1.37852799
66MP0003763_abnormal_thymus_physiology1.37769645
67MP0002736_abnormal_nociception_after1.33556775
68MP0005464_abnormal_platelet_physiology1.33455171
69MP0005636_abnormal_mineral_homeostasis1.32724174
70MP0005409_darkened_coat_color1.30377686
71MP0000685_abnormal_immune_system1.28327723
72MP0003879_abnormal_hair_cell1.25155189
73MP0004858_abnormal_nervous_system1.22989713
74MP0002557_abnormal_social/conspecific_i1.22348833
75MP0002160_abnormal_reproductive_system1.21197276
76MP0002064_seizures1.20177744
77MP0002735_abnormal_chemical_nociception1.19775836
78MP0002272_abnormal_nervous_system1.18710347
79MP0001440_abnormal_grooming_behavior1.15689111
80MP0002572_abnormal_emotion/affect_behav1.15193824
81MP0000383_abnormal_hair_follicle1.14791563
82MP0003866_abnormal_defecation1.14192054
83MP0003075_altered_response_to1.12681335
84MP0000858_altered_metastatic_potential1.12475123
85MP0000026_abnormal_inner_ear1.12162718
86MP0004264_abnormal_extraembryonic_tissu1.11953947
87MP0000372_irregular_coat_pigmentation1.11773297
88MP0003938_abnormal_ear_development1.11744210
89MP0002282_abnormal_trachea_morphology1.08164992
90MP0002419_abnormal_innate_immunity1.07266315
91MP0002163_abnormal_gland_morphology1.06051589
92MP0009333_abnormal_splenocyte_physiolog1.03631652
93MP0002095_abnormal_skin_pigmentation1.01857633
94MP0001963_abnormal_hearing_physiology1.00311558
95MP0005551_abnormal_eye_electrophysiolog1.00000970
96MP0006082_CNS_inflammation0.99483113
97MP0001800_abnormal_humoral_immune0.99332697
98MP0000569_abnormal_digit_pigmentation0.98940801
99MP0002067_abnormal_sensory_capabilities0.98576182
100MP0004947_skin_inflammation0.98080672
101MP0002876_abnormal_thyroid_physiology0.97854255
102MP0005058_abnormal_lysosome_morphology0.97009126
103MP0009764_decreased_sensitivity_to0.96789196
104MP0009643_abnormal_urine_homeostasis0.96586681
105MP0003635_abnormal_synaptic_transmissio0.96148113
106MP0005174_abnormal_tail_pigmentation0.96117063
107MP0005379_endocrine/exocrine_gland_phen0.95374056
108MP0000631_abnormal_neuroendocrine_gland0.94650371
109MP0002452_abnormal_antigen_presenting0.94221799
110MP0003690_abnormal_glial_cell0.93005418
111MP0001819_abnormal_immune_cell0.91142190
112MP0002136_abnormal_kidney_physiology0.90768169
113MP0002420_abnormal_adaptive_immunity0.90597434
114MP0001664_abnormal_digestion0.89955695
115MP0002909_abnormal_adrenal_gland0.89574508
116MP0001849_ear_inflammation0.88623792
117MP0008995_early_reproductive_senescence0.87776170
118MP0003453_abnormal_keratinocyte_physiol0.87776096
119MP0002177_abnormal_outer_ear0.87536048
120MP0005164_abnormal_response_to0.87427976
121MP0005451_abnormal_body_composition0.86588218
122MP0009763_increased_sensitivity_to0.86109638
123MP0001501_abnormal_sleep_pattern0.85423902
124MP0000762_abnormal_tongue_morphology0.85325341
125MP0009250_abnormal_appendicular_skeleto0.85134345
126MP0003937_abnormal_limbs/digits/tail_de0.85053112
127MP0002723_abnormal_immune_serum0.84549650
128MP0001177_atelectasis0.84124751
129MP0010386_abnormal_urinary_bladder0.84121952
130MP0009780_abnormal_chondrocyte_physiolo0.83583035
131MP0002398_abnormal_bone_marrow0.82187308
132MP0003828_pulmonary_edema0.82083942
133MP0005395_other_phenotype0.81987114
134MP0002063_abnormal_learning/memory/cond0.81975102
135MP0002734_abnormal_mechanical_nocicepti0.81595865
136MP0000613_abnormal_salivary_gland0.81433661
137MP0005000_abnormal_immune_tolerance0.81320364
138MP0003122_maternal_imprinting0.80909399
139MP0001905_abnormal_dopamine_level0.80827114
140MP0002254_reproductive_system_inflammat0.80708314
141MP0009785_altered_susceptibility_to0.80180113
142MP0000778_abnormal_nervous_system0.80112287
143MP0009765_abnormal_xenobiotic_induced0.79336357
144MP0002098_abnormal_vibrissa_morphology0.79309427
145MP0001845_abnormal_inflammatory_respons0.79238714
146MP0002998_abnormal_bone_remodeling0.79193309
147MP0002722_abnormal_immune_system0.78549687
148MP0004381_abnormal_hair_follicle0.78206481
149MP0005248_abnormal_Harderian_gland0.78105223
150MP0003385_abnormal_body_wall0.77268985
151MP0005671_abnormal_response_to0.76422255
152MP0002396_abnormal_hematopoietic_system0.76327048
153MP0001970_abnormal_pain_threshold0.74648137
154MP0001324_abnormal_eye_pigmentation0.74101073
155MP0005310_abnormal_salivary_gland0.74063246
156MP0002148_abnormal_hypersensitivity_rea0.73240002
157MP0005220_abnormal_exocrine_pancreas0.73001088
158MP0001663_abnormal_digestive_system0.72854941
159MP0001984_abnormal_olfaction0.72607684
160MP0003950_abnormal_plasma_membrane0.72004613
161MP0009379_abnormal_foot_pigmentation0.71749764
162MP0004883_abnormal_blood_vessel0.71621106
163MP0000689_abnormal_spleen_morphology0.70775546
164MP0010678_abnormal_skin_adnexa0.70398015
165MP0003633_abnormal_nervous_system0.69788875
166MP0004924_abnormal_behavior0.69689966
167MP0005386_behavior/neurological_phenoty0.69689966
168MP0002184_abnormal_innervation0.69164575
169MP0000716_abnormal_immune_system0.67754468
170MP0004859_abnormal_synaptic_plasticity0.67662261
171MP0001533_abnormal_skeleton_physiology0.67316782
172MP0000920_abnormal_myelination0.66731206
173MP0006036_abnormal_mitochondrial_physio0.65823925
174MP0002822_catalepsy0.65374328
175MP0003172_abnormal_lysosome_physiology0.63889608
176MP0008469_abnormal_protein_level0.63565100
177MP0002429_abnormal_blood_cell0.63173764
178MP0003300_gastrointestinal_ulcer0.60834627
179MP0001727_abnormal_embryo_implantation0.57280804
180MP0003806_abnormal_nucleotide_metabolis0.57261245
181MP0010234_abnormal_vibrissa_follicle0.57004926
182MP0001929_abnormal_gametogenesis0.55477886

Predicted human phenotypes

RankGene SetZ-score
1Chronic bronchitis (HP:0004469)7.89956683
2Bronchiectasis (HP:0002110)7.48030941
3Nasal polyposis (HP:0100582)7.22527121
4Abnormality of the nasal mucosa (HP:0000433)6.10423765
5Recurrent sinusitis (HP:0011108)4.96704342
6Parakeratosis (HP:0001036)4.92461899
7Bronchitis (HP:0012387)4.56006738
8Male infertility (HP:0003251)4.45743298
9Infertility (HP:0000789)4.30196250
10Recurrent otitis media (HP:0000403)4.26787596
11Osteomalacia (HP:0002749)4.24883895
12Follicular hyperkeratosis (HP:0007502)4.12209404
13Abnormal ciliary motility (HP:0012262)3.98615412
14Patchy hypopigmentation of hair (HP:0011365)3.96674306
15White forelock (HP:0002211)3.95429940
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.80855732
17Absent/shortened dynein arms (HP:0200106)3.80855732
18Alopecia of scalp (HP:0002293)3.71255586
19Absent eyebrow (HP:0002223)3.37946753
20Abnormal respiratory motile cilium physiology (HP:0012261)3.36690386
21Atelectasis (HP:0100750)3.35159165
22Unilateral renal agenesis (HP:0000122)3.32520142
23Abnormality of the heme biosynthetic pathway (HP:0010472)3.30308763
24Occipital encephalocele (HP:0002085)3.21060609
25Abnormal respiratory epithelium morphology (HP:0012253)3.16006253
26Abnormal respiratory motile cilium morphology (HP:0005938)3.16006253
27Prostate neoplasm (HP:0100787)3.09800235
28Chronic hepatic failure (HP:0100626)3.02549609
29Hypochromic microcytic anemia (HP:0004840)3.02122740
30Absent eyelashes (HP:0000561)3.01157146
31Abnormal hair whorl (HP:0010721)3.00970868
32Short middle phalanx of the 5th finger (HP:0004220)2.97937677
33Metabolic alkalosis (HP:0200114)2.94895392
34Abnormality of dental color (HP:0011073)2.93843799
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.92892959
36Duplicated collecting system (HP:0000081)2.88068213
37Abnormality of the renal collecting system (HP:0004742)2.87019523
38Hyperactive renin-angiotensin system (HP:0000841)2.83701810
39Septo-optic dysplasia (HP:0100842)2.83093668
40Recurrent corneal erosions (HP:0000495)2.81004621
41Tubulointerstitial nephritis (HP:0001970)2.74515407
42Cheilitis (HP:0100825)2.68646683
43Focal motor seizures (HP:0011153)2.66880859
44Hyperphosphatemia (HP:0002905)2.62921018
45Aplasia cutis congenita (HP:0001057)2.62875112
46Long nose (HP:0003189)2.54616291
47Median cleft lip (HP:0000161)2.53946408
48Aplasia involving bones of the upper limbs (HP:0009823)2.51153934
49Aplasia of the phalanges of the hand (HP:0009802)2.51153934
50Aplasia involving bones of the extremities (HP:0009825)2.51153934
51Rhinitis (HP:0012384)2.49935786
52Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.47707287
53Poikilocytosis (HP:0004447)2.41672920
54Hyperaldosteronism (HP:0000859)2.38665854
55Febrile seizures (HP:0002373)2.36209588
56Cystic liver disease (HP:0006706)2.31550148
57Myelomeningocele (HP:0002475)2.29418260
58True hermaphroditism (HP:0010459)2.28969890
59Recurrent bronchitis (HP:0002837)2.26416150
60Narrow nasal bridge (HP:0000446)2.25802408
61Decreased central vision (HP:0007663)2.23450836
62Pancreatic fibrosis (HP:0100732)2.22961219
63Abnormality of chloride homeostasis (HP:0011422)2.19837628
64Absent hair (HP:0002298)2.19454064
65Renal dysplasia (HP:0000110)2.17870455
66Chromsome breakage (HP:0040012)2.17462650
67Abnormality of midbrain morphology (HP:0002418)2.17383092
68Molar tooth sign on MRI (HP:0002419)2.17383092
69Tetany (HP:0001281)2.17060545
70Absent septum pellucidum (HP:0001331)2.16400403
71Aplasia/Hypoplasia of the tibia (HP:0005772)2.16100629
72Abnormality of incisor morphology (HP:0011063)2.13033127
73Congenital sensorineural hearing impairment (HP:0008527)2.11259298
74Nephronophthisis (HP:0000090)2.10770042
75Bilateral sensorineural hearing impairment (HP:0008619)2.07947046
76Postaxial foot polydactyly (HP:0001830)2.04470964
77Midline defect of the nose (HP:0004122)2.03390668
78Hypoplastic heart (HP:0001961)2.02722435
79Bell-shaped thorax (HP:0001591)2.02431175
80Renal salt wasting (HP:0000127)2.01827171
813-Methylglutaconic aciduria (HP:0003535)2.00542495
82Chronic otitis media (HP:0000389)2.00524487
83Pancreatic cysts (HP:0001737)2.00064231
84Conical tooth (HP:0000698)1.94568436
85Optic nerve hypoplasia (HP:0000609)1.93826676
86Abnormality of secondary sexual hair (HP:0009888)1.93701170
87Abnormality of the axillary hair (HP:0100134)1.93701170
88Abolished electroretinogram (ERG) (HP:0000550)1.93087728
89Absent frontal sinuses (HP:0002688)1.92696908
90Abnormality of renin-angiotensin system (HP:0000847)1.91991874
91Amelogenesis imperfecta (HP:0000705)1.91261312
92Abnormality of the nasolacrimal system (HP:0000614)1.90924769
93Hypoplastic left heart (HP:0004383)1.90103535
94Cutaneous syndactyly (HP:0012725)1.86829230
95Preaxial hand polydactyly (HP:0001177)1.85912025
96Morphological abnormality of the middle ear (HP:0008609)1.85196849
97Ectropion (HP:0000656)1.84171142
98Abnormality of the lacrimal duct (HP:0011481)1.84136814
99Humeroradial synostosis (HP:0003041)1.83013546
100Synostosis involving the elbow (HP:0003938)1.83013546
101Hyperkalemia (HP:0002153)1.80796506
102Corneal erosion (HP:0200020)1.79996235
103Submucous cleft hard palate (HP:0000176)1.79628352
104Acanthocytosis (HP:0001927)1.79445454
105Abnormality of the septum pellucidum (HP:0007375)1.79281086
106Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.79278721
107Nasolacrimal duct obstruction (HP:0000579)1.78295629
108Abnormality of molar morphology (HP:0011070)1.77456817
109Abnormality of molar (HP:0011077)1.77456817
110Male pseudohermaphroditism (HP:0000037)1.76025876
111Decreased circulating renin level (HP:0003351)1.75077393
112Hyperventilation (HP:0002883)1.74067948
113Abnormality of the right ventricle (HP:0001707)1.73726231
114Hypergonadotropic hypogonadism (HP:0000815)1.73450261
115Abnormality of the parietal bone (HP:0002696)1.73308099
116Chronic sinusitis (HP:0011109)1.68791319
117Congenital hepatic fibrosis (HP:0002612)1.67743500
118Abnormality of renal resorption (HP:0011038)1.67347381
119Asplenia (HP:0001746)1.67314177
120Abnormality of the dental root (HP:0006486)1.66805411
121Taurodontia (HP:0000679)1.66805411
122Abnormality of permanent molar morphology (HP:0011071)1.66805411
123Corneal dystrophy (HP:0001131)1.66670410
124Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.66362667
125Abnormality of the prostate (HP:0008775)1.65422354
126Anencephaly (HP:0002323)1.63450080
127Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.61768891
128Aplasia/Hypoplasia of the spleen (HP:0010451)1.61249908
129Abnormality of the renal medulla (HP:0100957)1.53414322
130Nephropathy (HP:0000112)1.53397612
131Hyponatremia (HP:0002902)1.48832975
132Glucose intolerance (HP:0000833)1.45135026
133Oculomotor apraxia (HP:0000657)1.43235308
134Abnormality of the distal phalanges of the toes (HP:0010182)1.38394118
135Obstructive sleep apnea (HP:0002870)1.37933315
136Hand muscle atrophy (HP:0009130)1.37625225
137Aplasia/Hypoplasia of the tongue (HP:0010295)1.37241399
138Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.36200026
139Diaphragmatic weakness (HP:0009113)1.34647974
140Sclerocornea (HP:0000647)1.30840462
141Medial flaring of the eyebrow (HP:0010747)1.30150248
142Hypokalemic alkalosis (HP:0001949)1.30149500
143Flat acetabular roof (HP:0003180)1.29973430
144Furrowed tongue (HP:0000221)1.22588847
145Abnormality of the frontal sinuses (HP:0002687)1.22443246
146Recurrent pneumonia (HP:0006532)1.19027186
147Muscle fiber splitting (HP:0003555)1.18236199
148Short thorax (HP:0010306)1.18035731
149Congenital primary aphakia (HP:0007707)1.17613209
150Postaxial hand polydactyly (HP:0001162)1.15453700
151Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.14772549
152Absent rod-and cone-mediated responses on ERG (HP:0007688)1.14438109
153Stridor (HP:0010307)1.14061928
154Elevated erythrocyte sedimentation rate (HP:0003565)1.13346627
155Gait imbalance (HP:0002141)1.11312961
156Recurrent abscess formation (HP:0002722)1.10552311
157Recurrent gram-negative bacterial infections (HP:0005420)1.10525677
158Abnormality of sodium homeostasis (HP:0010931)1.08768219
159Short femoral neck (HP:0100864)1.07602563
160Short nail (HP:0001799)1.07098939
161Recurrent bacterial skin infections (HP:0005406)1.06957828
162Upper limb amyotrophy (HP:0009129)1.05174955
163Distal upper limb amyotrophy (HP:0007149)1.05174955
164Fetal akinesia sequence (HP:0001989)1.05051142
165Distal lower limb muscle weakness (HP:0009053)1.03714296
166Spinal muscular atrophy (HP:0007269)1.03437841
167Abnormality of monocarboxylic acid metabolism (HP:0010996)1.02243951
168Self-mutilation (HP:0000742)1.01652840
169Nephrogenic diabetes insipidus (HP:0009806)1.00979848
170Purpura (HP:0000979)0.99960379
171Bifid scrotum (HP:0000048)0.99661680
172Tubular atrophy (HP:0000092)0.99538364
173Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)0.99481120
174Lip pit (HP:0100267)0.99171051
175Broad distal phalanx of finger (HP:0009836)0.97813874
176Abnormal vertebral ossification (HP:0100569)0.96242610
177Adrenal overactivity (HP:0002717)0.94724702

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.36501908
2SIK33.70205477
3SMG13.53957669
4BLK3.04343355
5PRPF4B2.91426215
6SIK22.74669519
7EEF2K2.59290383
8RIPK42.53127267
9NEK62.32336706
10EPHA42.25375721
11ADRBK22.25212651
12TRIB32.23924943
13CDK82.20772528
14BMPR1B2.15687496
15MAP3K32.04347824
16GRK72.02377233
17MAPKAPK31.96816224
18TXK1.91656406
19CSK1.89352011
20ZAK1.87132201
21NME11.80381467
22MKNK21.78160672
23SIK11.73045820
24FGR1.69957949
25MAP3K21.69795792
26PKN11.65509815
27LATS11.61884727
28TNIK1.61166535
29TBK11.60484114
30IRAK31.57762969
31MAPK131.54969468
32ERN11.54918396
33INSRR1.53688449
34GRK61.46054327
35MAP3K71.45253117
36ICK1.39395898
37MAP2K71.39224467
38LRRK21.35507448
39TNK21.31990090
40EPHB11.30825402
41NUAK11.26842649
42STK241.24077943
43TYK21.15798282
44FES1.11570893
45SGK2231.08907067
46SGK4941.08907067
47MAP2K31.08152410
48MARK31.07323788
49HIPK21.06177678
50MAPK151.05804411
51TAOK11.03878293
52MAP3K111.03450327
53STK101.03106236
54MAP4K11.01341556
55YES11.01269873
56DYRK1B1.00589446
57TTK1.00259341
58RIPK10.98956325
59SGK20.98675232
60IRAK40.97594902
61IRAK20.96577075
62PRKCE0.93697774
63BMPR20.93547728
64CAMKK10.90035678
65MST40.89970106
66TAOK20.89445158
67CAMK10.89264896
68WNK10.87185588
69BMX0.86156779
70TLK10.84103494
71MAPK70.83807570
72MKNK10.82179377
73PTK2B0.80833959
74BTK0.79597666
75FGFR20.79591099
76STK38L0.79211345
77PRKD20.78849641
78GRK10.78624972
79MAPK120.78394745
80AKT30.77519053
81MAP3K140.75438157
82EPHA30.75041336
83ZAP700.75008338
84TESK10.74157366
85MAPKAPK50.72042337
86PDPK10.71077782
87CAMK1D0.70485518
88NTRK30.69580889
89VRK10.69417262
90MARK10.69156924
91DYRK20.68343795
92NTRK20.67198603
93WNK30.67014090
94MAP3K100.63045648
95TRPM70.62256072
96CLK10.61458711
97EIF2AK20.60711963
98PASK0.60057260
99PIK3CA0.59886231
100DYRK1A0.59844604
101MUSK0.59713560
102ERBB30.59672476
103STK160.57211580
104MARK20.56675882
105CAMK2A0.56216172
106MAP3K10.56178878
107IKBKE0.55818434
108PTK60.55528016
109MAP3K80.54714541
110SYK0.54636545
111LYN0.54358230
112SCYL20.54289385
113CDK60.54190932
114CAMKK20.54014919
115CAMK40.53496996
116OXSR10.53371949
117MAP2K20.53197330
118CDK120.52377716
119TEC0.51997744
120PRKG10.51268592
121SGK10.50713710
122RPS6KA20.50705302
123PRKAA20.50426498
124RPS6KB20.49444592
125FER0.49350375
126PRKCQ0.49055387
127PRKCG0.48831041
128CDC42BPA0.48793516
129PRKCD0.48720627
130FGFR30.48209050
131CDK30.46269204
132CSNK1D0.45930917
133MAP3K60.45664261
134UHMK10.45608601
135EPHA20.45275331
136BRAF0.44999209
137STK390.43759381
138IRAK10.43718574
139MET0.43473978
140SGK30.43304986
141MAP3K130.43062589
142MAPK40.42132159
143STK30.41690046
144ADRBK10.41219269
145CSF1R0.40345801
146TIE10.40062710
147HCK0.40052333
148CSNK1A10.40041782
149PDK10.39879926
150MATK0.37816627
151MAP3K120.37104875
152PRKCI0.37035364
153IKBKB0.36808782
154CHUK0.36613908
155WNK40.36286797
156STK40.36010584
157MAPK110.34840582
158PRKACA0.34670888
159CSNK1A1L0.34666212
160KIT0.33500625
161RPS6KL10.32096187
162RPS6KC10.32096187
163MAP2K40.31359120
164AURKA0.30429207
165RET0.28426983
166ITK0.28138099
167PIM20.27985558
168JAK30.27946994
169NEK90.27916779
170MAP3K50.27583623
171FYN0.26675509
172STK380.25457861
173EIF2AK10.25255226
174PIM10.25047638
175AKT20.24668043
176STK110.21983836
177CDK90.20947593

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine metabolism_Homo sapiens_hsa003604.60888464
2Tyrosine metabolism_Homo sapiens_hsa003503.57887435
3Nicotine addiction_Homo sapiens_hsa050333.47548634
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.96342877
5Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.84328011
6Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.51096056
7Glutathione metabolism_Homo sapiens_hsa004802.45319930
8Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.03806673
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.02980631
10Morphine addiction_Homo sapiens_hsa050322.02977013
11Taste transduction_Homo sapiens_hsa047422.00169307
12SNARE interactions in vesicular transport_Homo sapiens_hsa041301.98348773
13Caffeine metabolism_Homo sapiens_hsa002321.92357555
14Huntingtons disease_Homo sapiens_hsa050161.90182542
15Serotonergic synapse_Homo sapiens_hsa047261.79382169
16GABAergic synapse_Homo sapiens_hsa047271.78655721
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.75256603
18Glutamatergic synapse_Homo sapiens_hsa047241.67785955
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.63989775
20Mineral absorption_Homo sapiens_hsa049781.61373920
21Axon guidance_Homo sapiens_hsa043601.56154489
22Retinol metabolism_Homo sapiens_hsa008301.54791545
23Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.54764462
24Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.52020145
25Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.51731683
26Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.51001048
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.47189243
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.45072670
29Sphingolipid metabolism_Homo sapiens_hsa006001.43275250
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.42506586
31Rheumatoid arthritis_Homo sapiens_hsa053231.41232791
32Steroid hormone biosynthesis_Homo sapiens_hsa001401.38890460
33Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.28802651
34Hepatitis C_Homo sapiens_hsa051601.27010848
35Calcium signaling pathway_Homo sapiens_hsa040201.25605026
36Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.25054592
37Carbohydrate digestion and absorption_Homo sapiens_hsa049731.23558515
38Circadian entrainment_Homo sapiens_hsa047131.22790129
39Asthma_Homo sapiens_hsa053101.19590798
40Ovarian steroidogenesis_Homo sapiens_hsa049131.19157030
41Leukocyte transendothelial migration_Homo sapiens_hsa046701.15127659
42Hematopoietic cell lineage_Homo sapiens_hsa046401.13319917
43African trypanosomiasis_Homo sapiens_hsa051431.11015712
44Primary immunodeficiency_Homo sapiens_hsa053401.09710236
45Notch signaling pathway_Homo sapiens_hsa043301.09377254
46Melanoma_Homo sapiens_hsa052181.06843227
47Salivary secretion_Homo sapiens_hsa049701.06522710
48B cell receptor signaling pathway_Homo sapiens_hsa046621.04884342
49Ether lipid metabolism_Homo sapiens_hsa005651.04702139
50Phototransduction_Homo sapiens_hsa047441.03936604
51Sulfur metabolism_Homo sapiens_hsa009201.03762282
52Acute myeloid leukemia_Homo sapiens_hsa052211.03583172
53Collecting duct acid secretion_Homo sapiens_hsa049661.02200667
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.01357058
55Leishmaniasis_Homo sapiens_hsa051400.97186823
56Toll-like receptor signaling pathway_Homo sapiens_hsa046200.95899502
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.95144609
58Long-term depression_Homo sapiens_hsa047300.95020563
59Insulin secretion_Homo sapiens_hsa049110.94536995
60Vitamin digestion and absorption_Homo sapiens_hsa049770.94427926
61Antigen processing and presentation_Homo sapiens_hsa046120.93797490
62Arachidonic acid metabolism_Homo sapiens_hsa005900.93407692
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.93090636
64Phagosome_Homo sapiens_hsa041450.92725889
65Graft-versus-host disease_Homo sapiens_hsa053320.92549204
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.92168295
67Malaria_Homo sapiens_hsa051440.90946704
68Olfactory transduction_Homo sapiens_hsa047400.90800299
69NF-kappa B signaling pathway_Homo sapiens_hsa040640.90135690
70Choline metabolism in cancer_Homo sapiens_hsa052310.88542498
71Gastric acid secretion_Homo sapiens_hsa049710.86510288
72Cholinergic synapse_Homo sapiens_hsa047250.86289593
73Other glycan degradation_Homo sapiens_hsa005110.85477471
74Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.85040185
75Drug metabolism - other enzymes_Homo sapiens_hsa009830.83702012
76Cocaine addiction_Homo sapiens_hsa050300.81785833
77Glycerophospholipid metabolism_Homo sapiens_hsa005640.81722148
78Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.81577352
79Lysosome_Homo sapiens_hsa041420.80129571
80Jak-STAT signaling pathway_Homo sapiens_hsa046300.77459278
81Transcriptional misregulation in cancer_Homo sapiens_hsa052020.77420181
82Measles_Homo sapiens_hsa051620.77098480
83Influenza A_Homo sapiens_hsa051640.76954183
84Wnt signaling pathway_Homo sapiens_hsa043100.76752663
85Synaptic vesicle cycle_Homo sapiens_hsa047210.76406533
86Autoimmune thyroid disease_Homo sapiens_hsa053200.76331357
87Linoleic acid metabolism_Homo sapiens_hsa005910.75893043
88Peroxisome_Homo sapiens_hsa041460.75320827
89Pancreatic cancer_Homo sapiens_hsa052120.74898817
90cAMP signaling pathway_Homo sapiens_hsa040240.72456167
91ErbB signaling pathway_Homo sapiens_hsa040120.69824580
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.69781490
93Tuberculosis_Homo sapiens_hsa051520.68088296
94Chemical carcinogenesis_Homo sapiens_hsa052040.67517872
95Herpes simplex infection_Homo sapiens_hsa051680.67243372
96Fatty acid degradation_Homo sapiens_hsa000710.65879708
97Renin secretion_Homo sapiens_hsa049240.65392779
98Vitamin B6 metabolism_Homo sapiens_hsa007500.64971000
99Glycosaminoglycan degradation_Homo sapiens_hsa005310.64815896
100Tight junction_Homo sapiens_hsa045300.63757267
101Apoptosis_Homo sapiens_hsa042100.63329566
102Toxoplasmosis_Homo sapiens_hsa051450.63227879
103Starch and sucrose metabolism_Homo sapiens_hsa005000.62468673
104ABC transporters_Homo sapiens_hsa020100.61814794
105Viral myocarditis_Homo sapiens_hsa054160.60995212
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.59426116
107Histidine metabolism_Homo sapiens_hsa003400.59376201
108Chronic myeloid leukemia_Homo sapiens_hsa052200.58776551
109Alcoholism_Homo sapiens_hsa050340.58295718
110Amphetamine addiction_Homo sapiens_hsa050310.57120285
111Ras signaling pathway_Homo sapiens_hsa040140.56724731
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55945978
113Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55032938
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.54855759
115Non-small cell lung cancer_Homo sapiens_hsa052230.54583207
116Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53661224
117Insulin resistance_Homo sapiens_hsa049310.53270861
118Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.53146064
119Allograft rejection_Homo sapiens_hsa053300.51533188
120Chemokine signaling pathway_Homo sapiens_hsa040620.49980369
121TNF signaling pathway_Homo sapiens_hsa046680.49821350
122Amoebiasis_Homo sapiens_hsa051460.49525576
123Arginine and proline metabolism_Homo sapiens_hsa003300.48231338
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.47871510
125Systemic lupus erythematosus_Homo sapiens_hsa053220.47461791
126Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.46006997
127Endocytosis_Homo sapiens_hsa041440.44850491
128Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.43865082
129beta-Alanine metabolism_Homo sapiens_hsa004100.43587608
130Type I diabetes mellitus_Homo sapiens_hsa049400.43419924
131Rap1 signaling pathway_Homo sapiens_hsa040150.43026512
132Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41214618
133Basal cell carcinoma_Homo sapiens_hsa052170.41188975
134alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.41047378
135mTOR signaling pathway_Homo sapiens_hsa041500.41037542
136MAPK signaling pathway_Homo sapiens_hsa040100.40813302
137Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.40601532
138Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.40343859
139cGMP-PKG signaling pathway_Homo sapiens_hsa040220.39924177
140Prostate cancer_Homo sapiens_hsa052150.38877673
141Staphylococcus aureus infection_Homo sapiens_hsa051500.38505552
142Melanogenesis_Homo sapiens_hsa049160.37989796
143Protein export_Homo sapiens_hsa030600.37785874
144Oxytocin signaling pathway_Homo sapiens_hsa049210.37615499
145Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.37009963
146Neurotrophin signaling pathway_Homo sapiens_hsa047220.36928178
147Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.36624400
148Aldosterone synthesis and secretion_Homo sapiens_hsa049250.36418626
149Osteoclast differentiation_Homo sapiens_hsa043800.36415516
150Viral carcinogenesis_Homo sapiens_hsa052030.35626142
151Fanconi anemia pathway_Homo sapiens_hsa034600.35492550
152Regulation of actin cytoskeleton_Homo sapiens_hsa048100.35210170
153Complement and coagulation cascades_Homo sapiens_hsa046100.31766494
154T cell receptor signaling pathway_Homo sapiens_hsa046600.31752257
155Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.30994586
156Endometrial cancer_Homo sapiens_hsa052130.29444578
157NOD-like receptor signaling pathway_Homo sapiens_hsa046210.29167859
158Hepatitis B_Homo sapiens_hsa051610.29076183
159Cyanoamino acid metabolism_Homo sapiens_hsa004600.27423170
160Regulation of autophagy_Homo sapiens_hsa041400.25515433

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