NHP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA3 proteins. These four H/ACA snoRNP proteins localize to the dense fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nhp2p. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.00442271
2DNA deamination (GO:0045006)5.51091651
3maturation of SSU-rRNA (GO:0030490)5.34225649
4energy coupled proton transport, down electrochemical gradient (GO:0015985)5.30931946
5ATP synthesis coupled proton transport (GO:0015986)5.30931946
6ribosomal small subunit assembly (GO:0000028)5.23358499
7chaperone-mediated protein transport (GO:0072321)5.20976007
8viral transcription (GO:0019083)5.02444674
9translational termination (GO:0006415)4.93374884
10ribosomal small subunit biogenesis (GO:0042274)4.89137825
11regulation of mitochondrial translation (GO:0070129)4.85507214
12ribosomal large subunit biogenesis (GO:0042273)4.83134390
13formation of translation preinitiation complex (GO:0001731)4.70427453
14DNA strand elongation involved in DNA replication (GO:0006271)4.67060660
15proteasome assembly (GO:0043248)4.56645346
16nucleobase biosynthetic process (GO:0046112)4.54672843
17telomere maintenance via semi-conservative replication (GO:0032201)4.53970253
18ribonucleoprotein complex biogenesis (GO:0022613)4.49211002
19translational elongation (GO:0006414)4.46158821
20DNA strand elongation (GO:0022616)4.43070350
21purine nucleobase biosynthetic process (GO:0009113)4.41944519
22translational initiation (GO:0006413)4.41365262
23ribosome assembly (GO:0042255)4.40130155
24mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.37366945
25DNA replication initiation (GO:0006270)4.35898342
26respiratory electron transport chain (GO:0022904)4.32429213
27ribosome biogenesis (GO:0042254)4.29934491
28electron transport chain (GO:0022900)4.24267498
29DNA replication checkpoint (GO:0000076)4.22121567
30protein complex biogenesis (GO:0070271)4.20482740
31SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.17845067
32mitochondrial respiratory chain complex assembly (GO:0033108)4.13191829
33cotranslational protein targeting to membrane (GO:0006613)4.07471660
34protein targeting to ER (GO:0045047)4.06297345
35nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)4.05088414
36telomere maintenance via recombination (GO:0000722)4.03867050
37mitotic metaphase plate congression (GO:0007080)4.00969285
38protein targeting to mitochondrion (GO:0006626)3.97331876
39spliceosomal snRNP assembly (GO:0000387)3.97262965
40mitochondrial respiratory chain complex I assembly (GO:0032981)3.96700000
41NADH dehydrogenase complex assembly (GO:0010257)3.96700000
42mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.96700000
43* rRNA processing (GO:0006364)3.94385160
44cellular protein complex disassembly (GO:0043624)3.89847366
45viral life cycle (GO:0019058)3.85182448
46establishment of protein localization to endoplasmic reticulum (GO:0072599)3.84788626
47protein localization to endoplasmic reticulum (GO:0070972)3.83871834
48negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.83548172
49transcription elongation from RNA polymerase III promoter (GO:0006385)3.82873600
50termination of RNA polymerase III transcription (GO:0006386)3.82873600
51respiratory chain complex IV assembly (GO:0008535)3.82135200
52* rRNA metabolic process (GO:0016072)3.80317511
53oxidative phosphorylation (GO:0006119)3.75636504
54CENP-A containing nucleosome assembly (GO:0034080)3.75420766
55pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.74850245
56establishment of protein localization to mitochondrion (GO:0072655)3.74057699
57mitotic recombination (GO:0006312)3.71945177
58translation (GO:0006412)3.71141261
59chromatin remodeling at centromere (GO:0031055)3.70622043
60anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.70547582
61positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.68558048
62regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.67649016
63cytochrome complex assembly (GO:0017004)3.66719559
64telomere maintenance via telomere lengthening (GO:0010833)3.63371539
65protein localization to mitochondrion (GO:0070585)3.62622786
66nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.54528377
67IMP biosynthetic process (GO:0006188)3.50791809
68negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.49721000
69negative regulation of ligase activity (GO:0051352)3.49721000
70DNA unwinding involved in DNA replication (GO:0006268)3.48899154
71regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.48337732
72cellular component biogenesis (GO:0044085)3.47950090
73transcription-coupled nucleotide-excision repair (GO:0006283)3.47266737
74protein localization to kinetochore (GO:0034501)3.46503658
75protein complex disassembly (GO:0043241)3.45603613
76nucleotide-excision repair, DNA gap filling (GO:0006297)3.42085071
77kinetochore assembly (GO:0051382)3.39709315
78spliceosomal complex assembly (GO:0000245)3.39252458
79cullin deneddylation (GO:0010388)3.36830534
80deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.35795392
81* pseudouridine synthesis (GO:0001522)3.34510125
82DNA replication-independent nucleosome organization (GO:0034724)3.34433974
83DNA replication-independent nucleosome assembly (GO:0006336)3.34433974
84mitotic nuclear envelope disassembly (GO:0007077)3.34010303
85kinetochore organization (GO:0051383)3.33164013
86DNA replication-dependent nucleosome organization (GO:0034723)3.33003430
87DNA replication-dependent nucleosome assembly (GO:0006335)3.33003430
88DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.32865601
89metaphase plate congression (GO:0051310)3.32288713
90establishment of viral latency (GO:0019043)3.31292103
91pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.31278755
92GTP biosynthetic process (GO:0006183)3.31224671
93inner mitochondrial membrane organization (GO:0007007)3.30515529
94macromolecular complex disassembly (GO:0032984)3.29976033
957-methylguanosine mRNA capping (GO:0006370)3.29175161
96signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.28598505
97signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.28598505
98signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.28598505
99intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.28071005
100signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.28071005
101protein deneddylation (GO:0000338)3.27807475
102folic acid-containing compound biosynthetic process (GO:0009396)3.27729132
103positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.27655652
104signal transduction involved in DNA damage checkpoint (GO:0072422)3.27097218
105signal transduction involved in DNA integrity checkpoint (GO:0072401)3.27097218
106cell cycle G1/S phase transition (GO:0044843)3.26754194
107G1/S transition of mitotic cell cycle (GO:0000082)3.26754194
108DNA damage response, detection of DNA damage (GO:0042769)3.25966234
109pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.25021414
110RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.23310066
111tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.23310066
112nuclear-transcribed mRNA catabolic process (GO:0000956)3.22806272
113establishment of protein localization to mitochondrial membrane (GO:0090151)3.22662428
114RNA capping (GO:0036260)3.22597997
1157-methylguanosine RNA capping (GO:0009452)3.22597997
116regulation of cellular amino acid metabolic process (GO:0006521)3.22532610
117protein neddylation (GO:0045116)3.22436156
118guanosine-containing compound biosynthetic process (GO:1901070)3.22423171
119signal transduction involved in cell cycle checkpoint (GO:0072395)3.21566237
120folic acid metabolic process (GO:0046655)3.19826639
121UTP biosynthetic process (GO:0006228)3.19709679
122transcription from RNA polymerase I promoter (GO:0006360)3.18892345
123establishment of integrated proviral latency (GO:0075713)3.18618008
124pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.16150468
125termination of RNA polymerase I transcription (GO:0006363)3.16081216
126regulation of ubiquitin-protein transferase activity (GO:0051438)3.14949969
127transcription elongation from RNA polymerase I promoter (GO:0006362)3.13491897
128maturation of 5.8S rRNA (GO:0000460)3.12836549
129purine nucleoside triphosphate biosynthetic process (GO:0009145)3.12480357
130positive regulation of ligase activity (GO:0051351)3.12097984
131exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.11242539
132peptidyl-histidine modification (GO:0018202)3.11072181
133viral mRNA export from host cell nucleus (GO:0046784)3.10337706
134histone exchange (GO:0043486)3.09163150
135protein localization to chromosome, centromeric region (GO:0071459)3.05785666
136membrane disassembly (GO:0030397)3.05732061
137nuclear envelope disassembly (GO:0051081)3.05732061
138mRNA catabolic process (GO:0006402)3.05485855

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.07619759
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.66155825
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.97753426
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.61927401
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.37990860
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.32110275
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.31246025
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.30767071
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.29188601
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.18454786
11MYC_18358816_ChIP-ChIP_MESCs_Mouse3.14721009
12FOXM1_23109430_ChIP-Seq_U2OS_Human3.07117183
13MYC_19030024_ChIP-ChIP_MESCs_Mouse3.01353542
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.98699632
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79246306
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.65213946
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.54894480
18E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.52492645
19XRN2_22483619_ChIP-Seq_HELA_Human2.50082638
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.44242080
21VDR_23849224_ChIP-Seq_CD4+_Human2.39807925
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.37253782
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.31399888
24E2F1_18555785_ChIP-Seq_MESCs_Mouse2.20330852
25DCP1A_22483619_ChIP-Seq_HELA_Human2.15110233
26* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.10061452
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00502693
28FOXP3_21729870_ChIP-Seq_TREG_Human1.98510130
29GABP_19822575_ChIP-Seq_HepG2_Human1.98435285
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.96653384
31TTF2_22483619_ChIP-Seq_HELA_Human1.95702967
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.94009820
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.92535143
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.89634947
35YY1_21170310_ChIP-Seq_MESCs_Mouse1.88485606
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.87784468
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85764916
38MYCN_18555785_ChIP-Seq_MESCs_Mouse1.82186261
39AR_21909140_ChIP-Seq_LNCAP_Human1.80004147
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72543581
41E2F1_21310950_ChIP-Seq_MCF-7_Human1.68175754
42ELK1_19687146_ChIP-ChIP_HELA_Human1.65994170
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.61665716
44SRF_21415370_ChIP-Seq_HL-1_Mouse1.59676707
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.59072651
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54288416
47FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.52966285
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.48950838
49ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48145823
50CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47272719
51POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42835719
52KDM5A_27292631_Chip-Seq_BREAST_Human1.41929800
53POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.40464364
54STAT3_1855785_ChIP-Seq_MESCs_Mouse1.38562200
55CIITA_25753668_ChIP-Seq_RAJI_Human1.38486972
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.37492753
57MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35894265
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.30530095
59SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.30406932
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.24698451
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.23650549
62PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.22339052
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.21984459
64CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.20899763
65KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20440337
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16839711
67ELK1_22589737_ChIP-Seq_MCF10A_Human1.16383964
68NOTCH1_21737748_ChIP-Seq_TLL_Human1.15687563
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14459235
70DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.12521985
71CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11593743
72BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.09051289
73ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08604094
74MYC_22102868_ChIP-Seq_BL_Human1.08003315
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07446528
76PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07401791
77* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.07130257
78DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.05556443
79SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04906310
80TFEB_21752829_ChIP-Seq_HELA_Human1.04611022
81ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.03952822
82CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03632528
83TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.03537644
84* FOXP1_21924763_ChIP-Seq_HESCs_Human1.01430536
85MYC_18940864_ChIP-ChIP_HL60_Human1.01206689
86CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00928603
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00689888
88ZNF263_19887448_ChIP-Seq_K562_Human0.98845896
89EGR1_19374776_ChIP-ChIP_THP-1_Human0.98797965
90PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97345827
91HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.96787210
92OCT4_18692474_ChIP-Seq_MEFs_Mouse0.93984313
93TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92923039
94SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92154093
95SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91432584
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.89769085
97SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.88485290
98HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.87630409
99KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.87388246
100KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.87388246
101KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.87388246
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86669246
103TP63_19390658_ChIP-ChIP_HaCaT_Human0.86542394
104* SPI1_23547873_ChIP-Seq_NB4_Human0.84112504
105NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.82896970
106CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82555723
107NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.81851961
108TBX5_21415370_ChIP-Seq_HL-1_Mouse0.80708781
109SOX2_16153702_ChIP-ChIP_HESCs_Human0.80592116
110* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.80546001
111GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.80165827
112NANOG_21062744_ChIP-ChIP_HESCs_Human0.79428663
113CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.79316470
114CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.77311703
115NANOG_16153702_ChIP-ChIP_HESCs_Human0.75875110
116* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.74598881
117TET1_21451524_ChIP-Seq_MESCs_Mouse0.72825252
118SOX17_20123909_ChIP-Seq_XEN_Mouse0.72279916
119FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71340210

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.23948637
2MP0004957_abnormal_blastocyst_morpholog5.02664172
3MP0003111_abnormal_nucleus_morphology4.73179461
4MP0010094_abnormal_chromosome_stability4.55899558
5MP0003077_abnormal_cell_cycle4.15060341
6MP0008057_abnormal_DNA_replication4.13723249
7MP0008058_abnormal_DNA_repair3.57148113
8MP0008932_abnormal_embryonic_tissue3.01094538
9MP0008007_abnormal_cellular_replicative2.84568839
10MP0003718_maternal_effect2.51659301
11MP0003786_premature_aging2.48190811
12MP0001730_embryonic_growth_arrest2.33007843
13MP0003123_paternal_imprinting2.26793159
14MP0000350_abnormal_cell_proliferation2.18711462
15MP0002396_abnormal_hematopoietic_system2.10555247
16MP0001529_abnormal_vocalization1.98220980
17MP0003806_abnormal_nucleotide_metabolis1.98207261
18MP0009379_abnormal_foot_pigmentation1.94390321
19MP0008877_abnormal_DNA_methylation1.94379250
20MP0010352_gastrointestinal_tract_polyps1.87658089
21MP0000372_irregular_coat_pigmentation1.87604097
22MP0009697_abnormal_copulation1.84339001
23MP0000490_abnormal_crypts_of1.82550743
24MP0002736_abnormal_nociception_after1.73206511
25MP0001697_abnormal_embryo_size1.65538533
26MP0008789_abnormal_olfactory_epithelium1.64365031
27MP0009333_abnormal_splenocyte_physiolog1.63371315
28MP0005380_embryogenesis_phenotype1.61850713
29MP0001672_abnormal_embryogenesis/_devel1.61850713
30MP0010307_abnormal_tumor_latency1.61317741
31MP0003186_abnormal_redox_activity1.59187513
32MP0002080_prenatal_lethality1.57823557
33MP0000313_abnormal_cell_death1.52059149
34MP0002019_abnormal_tumor_incidence1.45660766
35MP0003315_abnormal_perineum_morphology1.45146038
36MP0002163_abnormal_gland_morphology1.44911936
37MP0004147_increased_porphyrin_level1.42770999
38MP0003984_embryonic_growth_retardation1.40494390
39MP0002085_abnormal_embryonic_tissue1.36923668
40MP0002088_abnormal_embryonic_growth/wei1.36254790
41MP0002132_abnormal_respiratory_system1.34185153
42MP0003941_abnormal_skin_development1.33379380
43MP0006072_abnormal_retinal_apoptosis1.31217948
44MP0005397_hematopoietic_system_phenotyp1.24765376
45MP0001545_abnormal_hematopoietic_system1.24765376
46MP0002234_abnormal_pharynx_morphology1.22924479
47MP0006292_abnormal_olfactory_placode1.22366908
48MP0003567_abnormal_fetal_cardiomyocyte1.21166262
49MP0002086_abnormal_extraembryonic_tissu1.19649664
50MP0002210_abnormal_sex_determination1.19277024
51MP0010030_abnormal_orbit_morphology1.17255888
52MP0001853_heart_inflammation1.14449467
53MP0002084_abnormal_developmental_patter1.13836265
54MP0000358_abnormal_cell_content/1.12902262
55MP0005499_abnormal_olfactory_system1.12523636
56MP0005394_taste/olfaction_phenotype1.12523636
57MP0001145_abnormal_male_reproductive1.08732565
58MP0001905_abnormal_dopamine_level1.08549129
59MP0001968_abnormal_touch/_nociception1.08333543
60MP0003136_yellow_coat_color1.07574993
61MP0004197_abnormal_fetal_growth/weight/1.07463600
62MP0006035_abnormal_mitochondrial_morpho1.07294674
63MP0000049_abnormal_middle_ear1.07163193
64MP0006036_abnormal_mitochondrial_physio1.06078246
65MP0005646_abnormal_pituitary_gland1.04939107
66MP0001293_anophthalmia1.04252430
67MP0002160_abnormal_reproductive_system1.03180462
68MP0004133_heterotaxia0.99729528
69MP0004808_abnormal_hematopoietic_stem0.98109932
70MP0003890_abnormal_embryonic-extraembry0.96307287
71MP0002722_abnormal_immune_system0.96298479
72MP0003763_abnormal_thymus_physiology0.95776497
73MP0000858_altered_metastatic_potential0.94548311
74MP0000703_abnormal_thymus_morphology0.94119001
75MP0005075_abnormal_melanosome_morpholog0.93955344
76MP0008872_abnormal_physiological_respon0.92556322
77MP0005389_reproductive_system_phenotype0.92467857
78MP0000689_abnormal_spleen_morphology0.91036571
79MP0000653_abnormal_sex_gland0.90504784
80MP0001881_abnormal_mammary_gland0.89373497
81MP0002398_abnormal_bone_marrow0.89237099
82MP0001929_abnormal_gametogenesis0.89168675
83MP0003119_abnormal_digestive_system0.88514087
84MP0000750_abnormal_muscle_regeneration0.84519205
85MP0002751_abnormal_autonomic_nervous0.83922525
86MP0005084_abnormal_gallbladder_morpholo0.82227651
87MP0001346_abnormal_lacrimal_gland0.79894749
88MP0003880_abnormal_central_pattern0.79538973
89MP0005408_hypopigmentation0.78551416
90MP0005501_abnormal_skin_physiology0.78359982
91MP0002837_dystrophic_cardiac_calcinosis0.78144799
92MP0001119_abnormal_female_reproductive0.77802229
93MP0001188_hyperpigmentation0.77798640
94MP0005384_cellular_phenotype0.76662395
95MP0002429_abnormal_blood_cell0.76484880
96MP0001919_abnormal_reproductive_system0.75400895
97MP0003221_abnormal_cardiomyocyte_apopto0.75293014
98MP0002653_abnormal_ependyma_morphology0.74958615
99MP0002111_abnormal_tail_morphology0.74359304
100MP0003011_delayed_dark_adaptation0.74037099
101MP0005395_other_phenotype0.71526823
102MP0008875_abnormal_xenobiotic_pharmacok0.70066001
103MP0003937_abnormal_limbs/digits/tail_de0.69479344
104MP0008260_abnormal_autophagy0.69109554
105MP0005621_abnormal_cell_physiology0.68261671
106MP0000631_abnormal_neuroendocrine_gland0.66857784
107MP0005636_abnormal_mineral_homeostasis0.65445458
108MP0003698_abnormal_male_reproductive0.65422073
109MP0005645_abnormal_hypothalamus_physiol0.65025481
110MP0005266_abnormal_metabolism0.65002942
111MP0001764_abnormal_homeostasis0.64521413
112MP0002822_catalepsy0.63879025
113MP0005379_endocrine/exocrine_gland_phen0.63390571
114MP0000579_abnormal_nail_morphology0.61533385
115MP0002095_abnormal_skin_pigmentation0.60710627
116MP0000716_abnormal_immune_system0.60192430
117MP0002233_abnormal_nose_morphology0.59210617
118MP0005332_abnormal_amino_acid0.58796317
119MP0000537_abnormal_urethra_morphology0.57974127
120MP0001727_abnormal_embryo_implantation0.57348217
121MP0005174_abnormal_tail_pigmentation0.56683912
122MP0009672_abnormal_birth_weight0.56497708
123MP0003936_abnormal_reproductive_system0.56298735
124MP0005076_abnormal_cell_differentiation0.56110037
125MP0000627_abnormal_mammary_gland0.55079833
126MP0000477_abnormal_intestine_morphology0.54736822
127MP0001542_abnormal_bone_strength0.54549536
128MP0002277_abnormal_respiratory_mucosa0.54115916
129MP0009053_abnormal_anal_canal0.53228339
130MP0005023_abnormal_wound_healing0.53187587
131MP0001286_abnormal_eye_development0.52745220
132MP0003448_altered_tumor_morphology0.51479921
133MP0002102_abnormal_ear_morphology0.51336904
134MP0008995_early_reproductive_senescence0.48204642
135MP0002938_white_spotting0.45771495
136MP0003938_abnormal_ear_development0.45579598
137MP0003121_genomic_imprinting0.45213169

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)5.60958220
2Birth length less than 3rd percentile (HP:0003561)5.42384609
3Acute encephalopathy (HP:0006846)5.34940358
4Abnormal number of erythroid precursors (HP:0012131)5.26473007
5Reticulocytopenia (HP:0001896)5.22194241
6Progressive macrocephaly (HP:0004481)4.78151431
7Breast hypoplasia (HP:0003187)4.68069875
8Oral leukoplakia (HP:0002745)4.22339072
9Macrocytic anemia (HP:0001972)4.08340310
10Cerebral edema (HP:0002181)4.00402806
11Carpal bone hypoplasia (HP:0001498)3.78937072
12Cerebral hypomyelination (HP:0006808)3.76931281
13Renal Fanconi syndrome (HP:0001994)3.73465631
14Increased intramyocellular lipid droplets (HP:0012240)3.65865794
15Pallor (HP:0000980)3.57615279
16Lactic acidosis (HP:0003128)3.47072552
17Patellar aplasia (HP:0006443)3.35666809
18Aplastic anemia (HP:0001915)3.26481385
19Multiple enchondromatosis (HP:0005701)3.22712448
20Aplasia/Hypoplasia of the patella (HP:0006498)3.22562035
21Colon cancer (HP:0003003)3.16826442
22Exercise intolerance (HP:0003546)3.16506484
23Trismus (HP:0000211)3.16154479
24Absent thumb (HP:0009777)3.15993619
25Respiratory failure (HP:0002878)3.14452432
26Increased muscle lipid content (HP:0009058)3.09395046
27Selective tooth agenesis (HP:0001592)3.07550865
28Chromsome breakage (HP:0040012)3.01443132
29Absent radius (HP:0003974)2.98450838
30* Rough bone trabeculation (HP:0100670)2.96800487
31Abnormality of the preputium (HP:0100587)2.94929945
32Abnormality of the anterior horn cell (HP:0006802)2.91568606
33Degeneration of anterior horn cells (HP:0002398)2.91568606
34Chromosomal breakage induced by crosslinking agents (HP:0003221)2.90812558
35Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.89466866
36Aplasia/Hypoplasia of the sacrum (HP:0008517)2.87462139
37Meckel diverticulum (HP:0002245)2.85904891
38Premature ovarian failure (HP:0008209)2.82878936
39Microretrognathia (HP:0000308)2.81697360
40Aplasia involving forearm bones (HP:0009822)2.79857504
41Absent forearm bone (HP:0003953)2.79857504
42Abnormality of the ileum (HP:0001549)2.78134101
43Leukodystrophy (HP:0002415)2.76686353
44Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.73007919
45Decreased activity of mitochondrial respiratory chain (HP:0008972)2.73007919
46Secondary amenorrhea (HP:0000869)2.70574453
47Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.69980246
48Abnormal protein N-linked glycosylation (HP:0012347)2.69980246
49Abnormal protein glycosylation (HP:0012346)2.69980246
50Abnormal glycosylation (HP:0012345)2.69980246
51Reduced antithrombin III activity (HP:0001976)2.62037940
52Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.59626099
53Increased serum lactate (HP:0002151)2.58245281
54Cleft eyelid (HP:0000625)2.57772076
55Horseshoe kidney (HP:0000085)2.53886590
56Lethargy (HP:0001254)2.53027727
57Optic disc pallor (HP:0000543)2.51708522
58Sparse eyelashes (HP:0000653)2.51069732
59Abnormality of chromosome stability (HP:0003220)2.49335999
60Impulsivity (HP:0100710)2.49059502
61Increased hepatocellular lipid droplets (HP:0006565)2.45062490
62Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.40883087
63Progressive muscle weakness (HP:0003323)2.39403604
6411 pairs of ribs (HP:0000878)2.33654186
65Triphalangeal thumb (HP:0001199)2.29083018
66Myelodysplasia (HP:0002863)2.28930434
67Aplasia/Hypoplasia of the uvula (HP:0010293)2.28259356
68Agnosia (HP:0010524)2.26432061
69Methylmalonic aciduria (HP:0012120)2.25246279
70Hepatocellular necrosis (HP:0001404)2.24651794
71Exertional dyspnea (HP:0002875)2.24227966
72Increased CSF lactate (HP:0002490)2.23909282
73Mitochondrial inheritance (HP:0001427)2.23327669
74Glossoptosis (HP:0000162)2.22090266
75Hypoplasia of the radius (HP:0002984)2.21639885
763-Methylglutaconic aciduria (HP:0003535)2.18839182
77Emotional lability (HP:0000712)2.17859510
78* Premature graying of hair (HP:0002216)2.15544787
79Microvesicular hepatic steatosis (HP:0001414)2.14847321
80CNS hypomyelination (HP:0003429)2.14186685
81Megaloblastic anemia (HP:0001889)2.12640746
82Small intestinal stenosis (HP:0012848)2.10049452
83Duodenal stenosis (HP:0100867)2.10049452
84Abnormal number of incisors (HP:0011064)2.09739822
85Hyperglycinemia (HP:0002154)2.09230705
86* Pancytopenia (HP:0001876)2.08476922
87* Abnormal trabecular bone morphology (HP:0100671)2.07948593
88Methylmalonic acidemia (HP:0002912)2.07789853
89Medulloblastoma (HP:0002885)2.05911896
90Abnormality of renal resorption (HP:0011038)2.05834569
91Acute necrotizing encephalopathy (HP:0006965)2.05610763
92Lipid accumulation in hepatocytes (HP:0006561)2.05056800
93Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.03759033
94Abnormality of alanine metabolism (HP:0010916)2.03759033
95Hyperalaninemia (HP:0003348)2.03759033
96Ependymoma (HP:0002888)2.02901569
97Type I transferrin isoform profile (HP:0003642)2.02152854
98Poor head control (HP:0002421)2.02032164
99* Bone marrow hypocellularity (HP:0005528)2.01920517
100* Tracheoesophageal fistula (HP:0002575)2.01902158
101Hepatic necrosis (HP:0002605)2.01039481
102Supernumerary spleens (HP:0009799)1.99846006
103Atresia of the external auditory canal (HP:0000413)1.99674330
104* Neoplasm of the pancreas (HP:0002894)1.99282230
105* Cellular immunodeficiency (HP:0005374)1.99154501
106Stenosis of the external auditory canal (HP:0000402)1.98393188
107Aplasia/Hypoplasia involving the musculature (HP:0001460)1.95062773
108Abnormality of the labia minora (HP:0012880)1.94338097
109Abnormality of reticulocytes (HP:0004312)1.93960764
110Abnormality of the umbilical cord (HP:0010881)1.92676384
111Thrombocytosis (HP:0001894)1.91681496
112Muscle fiber atrophy (HP:0100295)1.88070184
113Squamous cell carcinoma (HP:0002860)1.88014392
114Personality changes (HP:0000751)1.87087533
115Abnormality of serum amino acid levels (HP:0003112)1.86544270
116Duplicated collecting system (HP:0000081)1.85479019
117Respiratory difficulties (HP:0002880)1.85194330
118Abnormality of dicarboxylic acid metabolism (HP:0010995)1.84764857
119Dicarboxylic aciduria (HP:0003215)1.84764857
120Short thumb (HP:0009778)1.84660220
121X-linked dominant inheritance (HP:0001423)1.84002986
122Generalized aminoaciduria (HP:0002909)1.82400542
123Increased serum pyruvate (HP:0003542)1.82334797
124Abnormality of glycolysis (HP:0004366)1.82334797
125Abnormal mitochondria in muscle tissue (HP:0008316)1.82248067
126Abnormal lung lobation (HP:0002101)1.82097059
127Aplasia/hypoplasia of the humerus (HP:0006507)1.81426396
128CNS demyelination (HP:0007305)1.80873467
129Abnormal spermatogenesis (HP:0008669)1.80669236
130Congenital, generalized hypertrichosis (HP:0004540)1.79881506
131Ureteral duplication (HP:0000073)1.78551512
132Abnormality of methionine metabolism (HP:0010901)1.78359421
133Facial cleft (HP:0002006)1.76353845
134Ragged-red muscle fibers (HP:0003200)1.75680621
135Type 2 muscle fiber atrophy (HP:0003554)1.75518832
136Progressive microcephaly (HP:0000253)1.72942317
137Abnormality of urine glucose concentration (HP:0011016)1.70448575
138Glycosuria (HP:0003076)1.70448575
139Hyperphosphaturia (HP:0003109)1.68975784
140Blindness (HP:0000618)1.66003638
141Death in infancy (HP:0001522)1.63284641
142Hypoplasia of the pons (HP:0012110)1.60637974
143Aplasia/hypoplasia of the uterus (HP:0008684)1.58943934
144Sclerocornea (HP:0000647)1.55200005

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK25.66590282
2BUB15.41813144
3WEE14.64680078
4EIF2AK13.70520534
5NME23.45437083
6CDC73.08130624
7SRPK12.96592918
8STK162.95184225
9PLK42.63457141
10TSSK62.40584039
11EIF2AK32.23664986
12TESK22.20656125
13TLK12.13036758
14TTK2.09771068
15VRK12.05748259
16NEK22.00451807
17PLK11.92444113
18BRSK21.88519278
19NUAK11.85530821
20EPHA21.84356667
21NEK11.84213445
22PIM21.78309953
23ACVR1B1.70973017
24CDK71.61638607
25DYRK31.60137458
26AURKB1.56296574
27RPS6KB21.50783880
28PLK31.42370197
29MKNK11.40654067
30NME11.38383151
31AURKA1.37574991
32ATR1.35598591
33MAP3K111.33745231
34RPS6KA41.32240752
35TAF11.29624506
36TRIM281.28788176
37ZAK1.23637190
38CHEK21.23636126
39BRSK11.20851053
40MAP4K21.19574586
41IRAK31.19556032
42MAP3K81.19077991
43MKNK21.16062724
44PBK1.14213448
45CSNK1G31.12740688
46PAK41.02668201
47KDR1.00275834
48CHEK10.97670289
49CCNB10.96707269
50PNCK0.94040899
51CDK40.93602729
52PASK0.93326151
53EIF2AK20.86431793
54CSNK1G10.85679525
55PIM10.85541441
56SCYL20.84557198
57BRAF0.81275799
58CSNK2A20.80564318
59CSNK2A10.78911223
60TESK10.77661551
61CSNK1A1L0.76658103
62SMG10.76289997
63ABL20.76117101
64CSNK1G20.75881792
65PAK10.75792932
66STK40.75685784
67STK100.74516459
68MST40.73097657
69PRKCI0.72914859
70MAP3K120.72129667
71LRRK20.67821312
72CDK20.67339024
73MUSK0.64806753
74BMPR1B0.64127505
75BCKDK0.63927929
76MAPKAPK30.63176468
77DYRK20.61788067
78ATM0.59389933
79AKT30.55922783
80ALK0.55661632
81IRAK40.55233554
82WNK30.54901639
83MAP4K10.54304486
84STK38L0.53394066
85MAP2K70.52208425
86RPS6KA50.52203589
87TAOK20.52107296
88TGFBR10.50380317
89LATS20.47967330
90MAPKAPK50.46636053
91BLK0.45301466
92CDK80.44987644
93CDK10.44005622
94CDK120.43006491
95GRK10.42479349
96ILK0.38128451
97INSRR0.37942880
98DAPK10.37080735
99MAP2K30.36389973
100CSNK1E0.33720215
101MAP3K30.33027580
102IKBKB0.32455324
103CSNK1A10.32405701
104PDK40.31740234
105PDK30.31740234
106CDK60.31417697
107ARAF0.29886799
108CAMK2G0.29264614
109AKT20.28263714
110FLT30.27557873
111PDK20.25261937
112CDK11A0.23951664
113CDK190.22622729
114CDK140.22189324
115PRKCG0.21816207
116LIMK10.21348837
117PINK10.20477400
118TEC0.19764759
119MELK0.19359026
120CLK10.19197307
121CDK180.18985210
122GRK60.18797497
123DAPK30.17708913
124PRKDC0.17618730

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030104.76906027
2DNA replication_Homo sapiens_hsa030304.68896811
3Proteasome_Homo sapiens_hsa030504.36635952
4RNA polymerase_Homo sapiens_hsa030204.00281279
5Mismatch repair_Homo sapiens_hsa034303.94794857
6* Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.77393377
7Spliceosome_Homo sapiens_hsa030403.30975425
8RNA transport_Homo sapiens_hsa030132.98786573
9Homologous recombination_Homo sapiens_hsa034402.90000296
10Pyrimidine metabolism_Homo sapiens_hsa002402.84193214
11Base excision repair_Homo sapiens_hsa034102.80919089
12Nucleotide excision repair_Homo sapiens_hsa034202.75616440
13One carbon pool by folate_Homo sapiens_hsa006702.39639608
14Cell cycle_Homo sapiens_hsa041102.17915328
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.13732699
16Fanconi anemia pathway_Homo sapiens_hsa034602.02645455
17Basal transcription factors_Homo sapiens_hsa030221.82730287
18RNA degradation_Homo sapiens_hsa030181.70736189
19Non-homologous end-joining_Homo sapiens_hsa034501.60173602
20Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.53859920
21Purine metabolism_Homo sapiens_hsa002301.50439596
22p53 signaling pathway_Homo sapiens_hsa041151.41960467
23Fatty acid elongation_Homo sapiens_hsa000621.37255724
24mRNA surveillance pathway_Homo sapiens_hsa030151.31433304
25Oxidative phosphorylation_Homo sapiens_hsa001901.25208704
26Parkinsons disease_Homo sapiens_hsa050121.25184641
27Huntingtons disease_Homo sapiens_hsa050161.23021215
28Epstein-Barr virus infection_Homo sapiens_hsa051691.22686027
29Pyruvate metabolism_Homo sapiens_hsa006201.17390991
30Folate biosynthesis_Homo sapiens_hsa007901.15083818
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.11373672
32Vitamin B6 metabolism_Homo sapiens_hsa007501.09885915
33Pentose phosphate pathway_Homo sapiens_hsa000301.05511317
34Protein export_Homo sapiens_hsa030601.00706383
35Cysteine and methionine metabolism_Homo sapiens_hsa002701.00215057
36Sulfur relay system_Homo sapiens_hsa041220.94887896
37Propanoate metabolism_Homo sapiens_hsa006400.91114529
38Cyanoamino acid metabolism_Homo sapiens_hsa004600.88741795
39Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.88155206
40Biosynthesis of amino acids_Homo sapiens_hsa012300.85648980
41Systemic lupus erythematosus_Homo sapiens_hsa053220.80349176
42Drug metabolism - other enzymes_Homo sapiens_hsa009830.79117094
43Glutathione metabolism_Homo sapiens_hsa004800.77846971
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75771954
45Herpes simplex infection_Homo sapiens_hsa051680.70175287
46Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.68769207
47Antigen processing and presentation_Homo sapiens_hsa046120.68696250
48Oocyte meiosis_Homo sapiens_hsa041140.68139069
49Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.64838744
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63011916
51Sulfur metabolism_Homo sapiens_hsa009200.61376971
52Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59091318
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58756212
54Peroxisome_Homo sapiens_hsa041460.58492741
55Steroid biosynthesis_Homo sapiens_hsa001000.58030932
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57777948
57Viral carcinogenesis_Homo sapiens_hsa052030.56635075
58Alzheimers disease_Homo sapiens_hsa050100.55766132
59Fructose and mannose metabolism_Homo sapiens_hsa000510.53017484
60Carbon metabolism_Homo sapiens_hsa012000.51149877
61Selenocompound metabolism_Homo sapiens_hsa004500.49537608
62Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49174839
632-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48428029
64Legionellosis_Homo sapiens_hsa051340.47430345
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44484811
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43200202
67HTLV-I infection_Homo sapiens_hsa051660.43193037
68Metabolic pathways_Homo sapiens_hsa011000.42211234
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40261056
70Tyrosine metabolism_Homo sapiens_hsa003500.38722182
71Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34274910
72Butanoate metabolism_Homo sapiens_hsa006500.33787536
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.33087048
74Primary immunodeficiency_Homo sapiens_hsa053400.33024265
75Thyroid cancer_Homo sapiens_hsa052160.32856236
76Arachidonic acid metabolism_Homo sapiens_hsa005900.32488507
77Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.30115887
78Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29952489
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29619847
80Galactose metabolism_Homo sapiens_hsa000520.29500024
81Fatty acid metabolism_Homo sapiens_hsa012120.29403386
82Regulation of autophagy_Homo sapiens_hsa041400.29182422
83Apoptosis_Homo sapiens_hsa042100.28582605
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28308355
85Phototransduction_Homo sapiens_hsa047440.25737812
86N-Glycan biosynthesis_Homo sapiens_hsa005100.25671264
87Tryptophan metabolism_Homo sapiens_hsa003800.25205470
88Arginine and proline metabolism_Homo sapiens_hsa003300.25115440
89Phenylalanine metabolism_Homo sapiens_hsa003600.24159363
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.23880489
91beta-Alanine metabolism_Homo sapiens_hsa004100.23547512
92Shigellosis_Homo sapiens_hsa051310.23479179
93Small cell lung cancer_Homo sapiens_hsa052220.23059624
94Collecting duct acid secretion_Homo sapiens_hsa049660.22239582
95Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.20610144
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.19708130
97Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.18328993
98Chemical carcinogenesis_Homo sapiens_hsa052040.18270883
99Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.17386212
100Measles_Homo sapiens_hsa051620.17262888
101NF-kappa B signaling pathway_Homo sapiens_hsa040640.16953960
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16465120
103HIF-1 signaling pathway_Homo sapiens_hsa040660.16444853
104MicroRNAs in cancer_Homo sapiens_hsa052060.15464364
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15183076
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.14687648
107Renin-angiotensin system_Homo sapiens_hsa046140.13420598
108Vibrio cholerae infection_Homo sapiens_hsa051100.12891488
109Fatty acid degradation_Homo sapiens_hsa000710.12180186
110Allograft rejection_Homo sapiens_hsa053300.11342464
111Bladder cancer_Homo sapiens_hsa052190.11277629
112Caffeine metabolism_Homo sapiens_hsa002320.11142458
113TGF-beta signaling pathway_Homo sapiens_hsa043500.10821373
114RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.10491607
115Hippo signaling pathway_Homo sapiens_hsa043900.10480896
116Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.09366754
117Nitrogen metabolism_Homo sapiens_hsa009100.09330055
118Linoleic acid metabolism_Homo sapiens_hsa005910.09217887
119Transcriptional misregulation in cancer_Homo sapiens_hsa052020.08614740
120Hematopoietic cell lineage_Homo sapiens_hsa046400.08571540
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.08195473
122Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.07973685
123Hepatitis B_Homo sapiens_hsa051610.07315332
124Influenza A_Homo sapiens_hsa051640.07291533
125Asthma_Homo sapiens_hsa053100.07022448
126Cardiac muscle contraction_Homo sapiens_hsa042600.06807497
127Alcoholism_Homo sapiens_hsa050340.06706250
128Graft-versus-host disease_Homo sapiens_hsa053320.05892315
129Vitamin digestion and absorption_Homo sapiens_hsa049770.05832445
130Steroid hormone biosynthesis_Homo sapiens_hsa001400.03062763
131Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.00146447

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