NHP2P1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA deamination (GO:0045006)7.10116464
2cellular ketone body metabolic process (GO:0046950)5.57106114
3ketone body metabolic process (GO:1902224)4.93646649
4platelet dense granule organization (GO:0060155)4.62488631
5water-soluble vitamin biosynthetic process (GO:0042364)4.41945975
6regulation of heat generation (GO:0031650)4.35583585
7regulation of penile erection (GO:0060405)4.24374058
8cytidine metabolic process (GO:0046087)4.09268810
9cytidine catabolic process (GO:0006216)4.09268810
10cytidine deamination (GO:0009972)4.09268810
11behavioral response to nicotine (GO:0035095)3.97775673
12behavioral response to ethanol (GO:0048149)3.96989466
13somite development (GO:0061053)3.96106099
14detection of light stimulus involved in sensory perception (GO:0050962)3.93945455
15detection of light stimulus involved in visual perception (GO:0050908)3.93945455
16response to nerve growth factor (GO:1990089)3.85132378
17cellular response to nerve growth factor stimulus (GO:1990090)3.85132378
18negative regulation of mast cell activation (GO:0033004)3.83947751
19cellular response to ATP (GO:0071318)3.77644851
20pyrimidine ribonucleoside catabolic process (GO:0046133)3.61585184
21positive regulation of T cell cytokine production (GO:0002726)3.56344670
22exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.52730014
23nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.47767693
24RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.44133042
25tachykinin receptor signaling pathway (GO:0007217)3.39215558
26mannosylation (GO:0097502)3.32387217
27regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.29031273
28nucleoside diphosphate catabolic process (GO:0009134)3.28723277
29regulation of immunoglobulin secretion (GO:0051023)3.12763735
30regulation of cilium movement (GO:0003352)3.12187071
31rRNA modification (GO:0000154)3.09721792
32regulation of action potential (GO:0098900)3.04259867
33regulation of meiosis I (GO:0060631)3.04130719
34response to xenobiotic stimulus (GO:0009410)3.03752464
35maturation of 5.8S rRNA (GO:0000460)3.00177472
36positive regulation of oligodendrocyte differentiation (GO:0048714)2.98607155
37pseudouridine synthesis (GO:0001522)2.98463411
38positive regulation of calcium-mediated signaling (GO:0050850)2.97814644
39purine nucleotide salvage (GO:0032261)2.96678276
40response to pheromone (GO:0019236)2.94470595
41aggressive behavior (GO:0002118)2.93158072
42protein neddylation (GO:0045116)2.93060131
43cerebral cortex radially oriented cell migration (GO:0021799)2.90229624
44maternal behavior (GO:0042711)2.89103878
45preassembly of GPI anchor in ER membrane (GO:0016254)2.85417435
46negative regulation of dendrite development (GO:2000171)2.85084303
47replication fork processing (GO:0031297)2.80835996
48positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.75039326
49regulation of NFAT protein import into nucleus (GO:0051532)2.73799973
50intestinal epithelial cell development (GO:0060576)2.73757032
51oxidative phosphorylation (GO:0006119)2.70327161
52substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.69609126
53substrate-independent telencephalic tangential migration (GO:0021826)2.69609126
54regulation of catecholamine metabolic process (GO:0042069)2.68650676
55regulation of dopamine metabolic process (GO:0042053)2.68650676
56adenosine metabolic process (GO:0046085)2.67581797
57regulation of calcium-mediated signaling (GO:0050848)2.64119501
58RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.63075085
59tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.63075085
60parental behavior (GO:0060746)2.59138761
61nucleotide transmembrane transport (GO:1901679)2.55414310
62dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.53892464
63response to amphetamine (GO:0001975)2.52924626
64sulfation (GO:0051923)2.50950690
65cornea development in camera-type eye (GO:0061303)2.48292636
66fear response (GO:0042596)2.47818501
67serotonin receptor signaling pathway (GO:0007210)2.47756768
68regulation of glycogen (starch) synthase activity (GO:2000465)2.47624033
69negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.47129134
70negative regulation of calcium ion transmembrane transport (GO:1903170)2.47129134
71phosphatidylinositol acyl-chain remodeling (GO:0036149)2.43581365
72regulation of cell maturation (GO:1903429)2.43393757
73regulation of uterine smooth muscle contraction (GO:0070472)2.42872327
74sulfate transmembrane transport (GO:1902358)2.42834323
75positive regulation of prostaglandin secretion (GO:0032308)2.40625802
76photoreceptor cell maintenance (GO:0045494)2.40604770
77positive regulation of phosphoprotein phosphatase activity (GO:0032516)2.40394755
78regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.40043426
79postsynaptic membrane organization (GO:0001941)2.38882491
80negative regulation of membrane potential (GO:0045837)2.35862712
81ubiquinone biosynthetic process (GO:0006744)2.33945257
82positive regulation of defense response to virus by host (GO:0002230)2.33942682
83purine-containing compound salvage (GO:0043101)2.32223818
84behavioral defense response (GO:0002209)2.31700548
85behavioral fear response (GO:0001662)2.31700548
86lateral ventricle development (GO:0021670)2.31400741
87neural tube formation (GO:0001841)2.31167233
88L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.29991270
89adult feeding behavior (GO:0008343)2.29948736
90regulation of neurotransmitter uptake (GO:0051580)2.29085850
91positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.28532354
92brain morphogenesis (GO:0048854)2.28140314
93ubiquinone metabolic process (GO:0006743)2.27478609
94negative regulation of T cell apoptotic process (GO:0070233)2.27051104
95adaptation of signaling pathway (GO:0023058)2.26999105
96regulation of microtubule-based movement (GO:0060632)2.26776512
97regulation of pigment cell differentiation (GO:0050932)2.25244010
98GPI anchor metabolic process (GO:0006505)2.24915018
99dopaminergic neuron differentiation (GO:0071542)2.24191039
100regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.24099763

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse4.33437145
2GBX2_23144817_ChIP-Seq_PC3_Human3.10201974
3EZH2_22144423_ChIP-Seq_EOC_Human3.09939268
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.86265135
5FLI1_27457419_Chip-Seq_LIVER_Mouse2.85390649
6VDR_22108803_ChIP-Seq_LS180_Human2.76689906
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.52065119
8IGF1R_20145208_ChIP-Seq_DFB_Human2.48106234
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.47310520
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.39097940
11PCGF2_27294783_Chip-Seq_ESCs_Mouse2.32141396
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.27137652
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.22802713
14TAF15_26573619_Chip-Seq_HEK293_Human2.05624797
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.04955954
16CTBP1_25329375_ChIP-Seq_LNCAP_Human2.04213003
17ZNF274_21170338_ChIP-Seq_K562_Hela2.01281608
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.00666645
19EWS_26573619_Chip-Seq_HEK293_Human1.99298962
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99235948
21PCGF2_27294783_Chip-Seq_NPCs_Mouse1.92405390
22CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91861331
23FUS_26573619_Chip-Seq_HEK293_Human1.85242392
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.81685661
25P300_19829295_ChIP-Seq_ESCs_Human1.79233375
26TP53_22573176_ChIP-Seq_HFKS_Human1.77699655
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.75055361
28KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.72739356
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.72165155
30MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.69831080
31SOX2_19829295_ChIP-Seq_ESCs_Human1.67346271
32NANOG_19829295_ChIP-Seq_ESCs_Human1.67346271
33NOTCH1_21737748_ChIP-Seq_TLL_Human1.66933449
34HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.61889190
35NFE2_27457419_Chip-Seq_LIVER_Mouse1.60636646
36EZH2_27294783_Chip-Seq_NPCs_Mouse1.59275249
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.57396262
38EZH2_27304074_Chip-Seq_ESCs_Mouse1.55040275
39TP63_19390658_ChIP-ChIP_HaCaT_Human1.52292162
40CBP_20019798_ChIP-Seq_JUKART_Human1.51279223
41IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.51279223
42CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.45418846
43SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43000076
44IRF8_21731497_ChIP-ChIP_J774_Mouse1.42230769
45CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34777635
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.33769625
47SMAD4_21799915_ChIP-Seq_A2780_Human1.31751989
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.31211550
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.30961645
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.30449660
51MYC_18940864_ChIP-ChIP_HL60_Human1.29144349
52ER_23166858_ChIP-Seq_MCF-7_Human1.27556931
53BCAT_22108803_ChIP-Seq_LS180_Human1.27477119
54JARID2_20064375_ChIP-Seq_MESCs_Mouse1.25532954
55TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24703349
56STAT3_23295773_ChIP-Seq_U87_Human1.24302730
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22039831
58AUTS2_25519132_ChIP-Seq_293T-REX_Human1.21515917
59CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21336539
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.20020537
61GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.19979800
62NANOG_18555785_Chip-Seq_ESCs_Mouse1.19293980
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.18652720
64P53_22387025_ChIP-Seq_ESCs_Mouse1.18497046
65AR_21572438_ChIP-Seq_LNCaP_Human1.17581149
66TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16610824
67FOXA1_25329375_ChIP-Seq_VCAP_Human1.16335968
68FOXA1_27270436_Chip-Seq_PROSTATE_Human1.16335968
69REST_21632747_ChIP-Seq_MESCs_Mouse1.16310546
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.15840524
71WDR5_24793694_ChIP-Seq_LNCAP_Human1.15267026
72HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.14253253
73HOXB7_26014856_ChIP-Seq_BT474_Human1.13714632
74TCF4_23295773_ChIP-Seq_U87_Human1.12618288
75TDRD3_21172665_ChIP-Seq_MCF-7_Human1.09122042
76ETV2_25802403_ChIP-Seq_MESCs_Mouse1.08129055
77MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07915501
78GABP_17652178_ChIP-ChIP_JURKAT_Human1.07891058
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.07563898
80SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.07308665
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.06790226
82SMAD4_21741376_ChIP-Seq_EPCs_Human1.06071557
83PRDM14_20953172_ChIP-Seq_ESCs_Human1.05243135
84SUZ12_18555785_Chip-Seq_ESCs_Mouse1.03842651
85FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03513493
86CRX_20693478_ChIP-Seq_RETINA_Mouse1.02400215
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01982388
88RNF2_27304074_Chip-Seq_NSC_Mouse1.01073756
89AR_25329375_ChIP-Seq_VCAP_Human1.00502024
90RUNX2_22187159_ChIP-Seq_PCA_Human0.99881662
91SALL1_21062744_ChIP-ChIP_HESCs_Human0.99844732
92ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99768626
93STAT3_18555785_Chip-Seq_ESCs_Mouse0.99764135
94KLF5_20875108_ChIP-Seq_MESCs_Mouse0.99065905
95SOX9_26525672_Chip-Seq_Limbbuds_Mouse0.98871645
96TCF4_22108803_ChIP-Seq_LS180_Human0.97880600
97OCT4_21477851_ChIP-Seq_ESCs_Mouse0.97564273
98MYC_19829295_ChIP-Seq_ESCs_Human0.96641546
99NCOR_22424771_ChIP-Seq_293T_Human0.96521610
100ETV1_20927104_ChIP-Seq_GIST48_Human0.94775308

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation4.33189491
2MP0009379_abnormal_foot_pigmentation3.10186628
3MP0002837_dystrophic_cardiac_calcinosis2.98726031
4MP0004043_abnormal_pH_regulation2.88017089
5MP0002138_abnormal_hepatobiliary_system2.51894025
6MP0004885_abnormal_endolymph2.23684957
7MP0003195_calcinosis2.18582281
8MP0002234_abnormal_pharynx_morphology2.07519082
9MP0003880_abnormal_central_pattern2.05798244
10MP0006276_abnormal_autonomic_nervous2.04800075
11MP0001968_abnormal_touch/_nociception2.02649007
12MP0002822_catalepsy1.98226442
13MP0002735_abnormal_chemical_nociception1.98092384
14MP0003787_abnormal_imprinting1.96337398
15MP0001188_hyperpigmentation1.88598654
16MP0000569_abnormal_digit_pigmentation1.75950925
17MP0006054_spinal_hemorrhage1.72235046
18MP0002095_abnormal_skin_pigmentation1.69485210
19MP0005671_abnormal_response_to1.68229364
20MP0001764_abnormal_homeostasis1.67483293
21MP0005551_abnormal_eye_electrophysiolog1.58012827
22MP0005645_abnormal_hypothalamus_physiol1.50454982
23MP0003646_muscle_fatigue1.50174174
24MP0002277_abnormal_respiratory_mucosa1.49711166
25MP0002733_abnormal_thermal_nociception1.48654095
26MP0008875_abnormal_xenobiotic_pharmacok1.44805825
27MP0006072_abnormal_retinal_apoptosis1.42579696
28MP0008872_abnormal_physiological_respon1.36884646
29MP0004484_altered_response_of1.34940269
30MP0009745_abnormal_behavioral_response1.34506596
31MP0003693_abnormal_embryo_hatching1.34000054
32MP0000427_abnormal_hair_cycle1.32774055
33MP0002572_abnormal_emotion/affect_behav1.29932493
34MP0005253_abnormal_eye_physiology1.28264586
35MP0004142_abnormal_muscle_tone1.27822552
36MP0002184_abnormal_innervation1.26289394
37MP0002102_abnormal_ear_morphology1.23287444
38MP0005386_behavior/neurological_phenoty1.23126604
39MP0004924_abnormal_behavior1.23126604
40MP0002736_abnormal_nociception_after1.21731372
41MP0000015_abnormal_ear_pigmentation1.21709209
42MP0005075_abnormal_melanosome_morpholog1.21269046
43MP0002638_abnormal_pupillary_reflex1.21030569
44MP0001905_abnormal_dopamine_level1.20801903
45MP0000778_abnormal_nervous_system1.19847295
46MP0003045_fibrosis1.17874524
47MP0001970_abnormal_pain_threshold1.16785127
48MP0005174_abnormal_tail_pigmentation1.15882188
49MP0002272_abnormal_nervous_system1.15451619
50MP0008877_abnormal_DNA_methylation1.13751664
51MP0000647_abnormal_sebaceous_gland1.13156761
52MP0001324_abnormal_eye_pigmentation1.11905349
53MP0002168_other_aberrant_phenotype1.08590369
54MP0006036_abnormal_mitochondrial_physio1.06438697
55MP0006292_abnormal_olfactory_placode1.03156115
56MP0005220_abnormal_exocrine_pancreas1.02517028
57MP0009764_decreased_sensitivity_to1.02492287
58MP0002938_white_spotting1.01925208
59MP0003136_yellow_coat_color1.00661829
60MP0008995_early_reproductive_senescence0.99769952
61MP0002148_abnormal_hypersensitivity_rea0.98856417
62MP0003011_delayed_dark_adaptation0.98659887
63MP0001501_abnormal_sleep_pattern0.97391321
64MP0004782_abnormal_surfactant_physiolog0.96673164
65MP0010386_abnormal_urinary_bladder0.94867061
66MP0003252_abnormal_bile_duct0.93470550
67MP0002063_abnormal_learning/memory/cond0.90652011
68MP0003635_abnormal_synaptic_transmissio0.90160875
69MP0008775_abnormal_heart_ventricle0.89735222
70MP0000049_abnormal_middle_ear0.86819520
71MP0009046_muscle_twitch0.86617724
72MP0001944_abnormal_pancreas_morphology0.86261870
73MP0000613_abnormal_salivary_gland0.86108789
74MP0003638_abnormal_response/metabolism_0.85945561
75MP0000631_abnormal_neuroendocrine_gland0.85745562
76MP0002160_abnormal_reproductive_system0.85647108
77MP0001986_abnormal_taste_sensitivity0.85070769
78MP0005395_other_phenotype0.84879206
79MP0001835_abnormal_antigen_presentation0.84695001
80MP0010329_abnormal_lipoprotein_level0.84275499
81MP0009250_abnormal_appendicular_skeleto0.83743860
82MP0003718_maternal_effect0.83405561
83MP0002249_abnormal_larynx_morphology0.83365355
84MP0003567_abnormal_fetal_cardiomyocyte0.82647685
85MP0002557_abnormal_social/conspecific_i0.81031642
86MP0001529_abnormal_vocalization0.79205864
87MP0008569_lethality_at_weaning0.77129153
88MP0008058_abnormal_DNA_repair0.76652370
89MP0003186_abnormal_redox_activity0.75800265
90MP0005389_reproductive_system_phenotype0.75670186
91MP0003119_abnormal_digestive_system0.74448986
92MP0003724_increased_susceptibility_to0.74351209
93MP0002233_abnormal_nose_morphology0.73571214
94MP0000230_abnormal_systemic_arterial0.72078207
95MP0001984_abnormal_olfaction0.71893874
96MP0003890_abnormal_embryonic-extraembry0.71703359
97MP0002752_abnormal_somatic_nervous0.70090756
98MP0003806_abnormal_nucleotide_metabolis0.69994747
99MP0005646_abnormal_pituitary_gland0.69040414
100MP0003786_premature_aging0.68542696

Predicted human phenotypes

RankGene SetZ-score
1Ketoacidosis (HP:0001993)4.49370666
2Reduced antithrombin III activity (HP:0001976)4.23814040
3Pancreatic cysts (HP:0001737)3.88763423
4Ketosis (HP:0001946)3.63948947
5Amyotrophic lateral sclerosis (HP:0007354)3.63381958
6Methylmalonic acidemia (HP:0002912)3.56041432
7Pancreatic fibrosis (HP:0100732)3.43956123
8Hyperglycinemia (HP:0002154)3.38755732
9Stomatitis (HP:0010280)3.30453400
10Acute necrotizing encephalopathy (HP:0006965)3.26923978
11Type I transferrin isoform profile (HP:0003642)3.25254806
12Progressive macrocephaly (HP:0004481)3.17445214
13Dry hair (HP:0011359)3.14159403
14Conical tooth (HP:0000698)3.08500754
15Methylmalonic aciduria (HP:0012120)3.06292858
16Volvulus (HP:0002580)3.05451000
17Molar tooth sign on MRI (HP:0002419)3.04536310
18Abnormality of midbrain morphology (HP:0002418)3.04536310
19Testicular atrophy (HP:0000029)3.03704603
20Amelogenesis imperfecta (HP:0000705)2.90239310
21True hermaphroditism (HP:0010459)2.89379451
22Abolished electroretinogram (ERG) (HP:0000550)2.88987509
23Congenital stationary night blindness (HP:0007642)2.81353199
24Decreased central vision (HP:0007663)2.77019714
25Thyroiditis (HP:0100646)2.76084457
26Type 2 muscle fiber atrophy (HP:0003554)2.69964129
27Long nose (HP:0003189)2.67654505
28Abnormality of the renal cortex (HP:0011035)2.67119098
29Abnormal protein glycosylation (HP:0012346)2.66933998
30Abnormal glycosylation (HP:0012345)2.66933998
31Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.66933998
32Abnormal protein N-linked glycosylation (HP:0012347)2.66933998
33Attenuation of retinal blood vessels (HP:0007843)2.65753674
34Abnormal mitochondria in muscle tissue (HP:0008316)2.64073152
35Acute encephalopathy (HP:0006846)2.63742615
36Abnormal rod and cone electroretinograms (HP:0008323)2.57048976
37Tachypnea (HP:0002789)2.53040393
38Optic disc pallor (HP:0000543)2.51735397
39Broad-based gait (HP:0002136)2.50917317
40Abnormality of the prostate (HP:0008775)2.50824743
41Renal cortical cysts (HP:0000803)2.48937908
42Severe combined immunodeficiency (HP:0004430)2.48005912
43Pendular nystagmus (HP:0012043)2.47007870
44Pachygyria (HP:0001302)2.46427358
45Nephronophthisis (HP:0000090)2.43688235
46Abnormality of endocrine pancreas physiology (HP:0012093)2.40819909
47Abnormality of the pancreatic islet cells (HP:0006476)2.40819909
48Lissencephaly (HP:0001339)2.40433451
49Decreased circulating renin level (HP:0003351)2.33897066
50Aplastic anemia (HP:0001915)2.30210337
51Abnormality of macular pigmentation (HP:0008002)2.26455910
52Inability to walk (HP:0002540)2.25377497
53Pancytopenia (HP:0001876)2.22317513
54Cystic liver disease (HP:0006706)2.18070873
55Abnormality of the renal medulla (HP:0100957)2.17081512
56Choroideremia (HP:0001139)2.16669633
57Abnormality of glycine metabolism (HP:0010895)2.16008004
58Abnormality of serine family amino acid metabolism (HP:0010894)2.16008004
59Abnormal drinking behavior (HP:0030082)2.15815448
60Polydipsia (HP:0001959)2.15815448
61Mitochondrial inheritance (HP:0001427)2.15182425
62Abnormality of DNA repair (HP:0003254)2.15097806
63Metaphyseal dysplasia (HP:0100255)2.14162106
64Hypoproteinemia (HP:0003075)2.13844641
65Generalized aminoaciduria (HP:0002909)2.12472309
66Pancreatic islet-cell hyperplasia (HP:0004510)2.11932099
67Muscle fiber atrophy (HP:0100295)2.10095011
68Cerebral edema (HP:0002181)2.09946769
69Constricted visual fields (HP:0001133)2.07678999
70Absent rod-and cone-mediated responses on ERG (HP:0007688)2.06677171
71Progressive inability to walk (HP:0002505)2.01472473
72Abnormality of the corticospinal tract (HP:0002492)1.97840400
73Chorioretinal atrophy (HP:0000533)1.93549408
74Muscular hypotonia of the trunk (HP:0008936)1.92850834
75Increased CSF lactate (HP:0002490)1.92382581
76Tubular atrophy (HP:0000092)1.91164360
77Atrophy/Degeneration involving motor neurons (HP:0007373)1.89536391
78Polyuria (HP:0000103)1.89034433
79Abnormality of eosinophils (HP:0001879)1.86897247
80Abnormality of the vitamin B12 metabolism (HP:0004341)1.86489444
81Abnormality of vitamin B metabolism (HP:0004340)1.86352659
82Febrile seizures (HP:0002373)1.86163096
83Autoimmune hemolytic anemia (HP:0001890)1.85663219
84Autoimmune thrombocytopenia (HP:0001973)1.84443813
85Bony spicule pigmentary retinopathy (HP:0007737)1.82271459
86Albinism (HP:0001022)1.82034833
87Concave nail (HP:0001598)1.77843423
88Congenital sensorineural hearing impairment (HP:0008527)1.75923859
89Hypoplastic iliac wings (HP:0002866)1.75811467
90Keratoconus (HP:0000563)1.75294666
91Increased corneal curvature (HP:0100692)1.75294666
92Hypokalemic alkalosis (HP:0001949)1.73816408
93Decreased electroretinogram (ERG) amplitude (HP:0000654)1.73794942
94Severe visual impairment (HP:0001141)1.73628141
95Abnormal biliary tract physiology (HP:0012439)1.70998232
96Bile duct proliferation (HP:0001408)1.70998232
97Aplasia/Hypoplasia of the tibia (HP:0005772)1.70869500
98Prostate neoplasm (HP:0100787)1.70751763
99Poor speech (HP:0002465)1.69914375
100Decreased activity of mitochondrial respiratory chain (HP:0008972)1.69059240

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.08440685
2MARK13.93654049
3FRK3.85751211
4MAP3K93.79562411
5TAOK33.64859663
6PNCK2.85774708
7ZAK2.62579852
8TNIK2.57161203
9ADRBK22.29571420
10BCR2.17387803
11TAF12.15776206
12PIK3CG2.12961690
13TLK12.08971806
14GRK11.92641800
15BUB11.85932668
16TGFBR21.64826090
17BCKDK1.61851100
18KDR1.61037075
19NUAK11.58878139
20VRK21.57972166
21MAP4K21.53608150
22LATS11.44440132
23CDC42BPA1.43402121
24VRK11.39022132
25TESK21.16319116
26TXK1.15296604
27ADRBK11.12615339
28DYRK21.12162584
29AKT31.06909502
30SRPK11.02743233
31STK38L1.02020093
32CLK11.00963888
33INSRR0.97255866
34GRK50.96913957
35ITK0.92849000
36CSNK1A1L0.91061853
37SGK20.90516651
38FGFR20.89573133
39CDK30.89303107
40MATK0.87733294
41WNK40.85785854
42OXSR10.84102572
43STK160.82268722
44PINK10.80066529
45KIT0.79958781
46WNK30.78857609
47FES0.76986129
48TIE10.72281752
49GRK60.71362453
50CAMK1G0.70614776
51NLK0.69727628
52STK390.68802140
53CSNK1G30.67998181
54LCK0.66802646
55TEC0.65004977
56CSNK1G10.64783985
57BMPR1B0.64696743
58RPS6KA40.64640371
59CSNK1G20.63907850
60PRKCE0.63787834
61EPHA40.63644549
62MAP2K70.63612037
63ACVR1B0.61781897
64RPS6KA50.61628491
65AURKA0.61603118
66MAPK130.59928224
67ABL10.58496828
68EIF2AK30.58219782
69ERBB30.57256596
70PHKG10.57204133
71PHKG20.57204133
72GRK70.57142671
73WNK10.56580416
74RPS6KA60.55541176
75SGK2230.53870754
76SGK4940.53870754
77IKBKE0.52216591
78CAMK2A0.51957149
79NTRK20.51190476
80SYK0.51036492
81MKNK10.50893329
82PLK40.47812011
83HCK0.46918833
84STK30.45446162
85IKBKB0.44596386
86ATM0.43960571
87OBSCN0.43813796
88RPS6KC10.43720980
89RPS6KL10.43720980
90PRKCG0.43576281
91SCYL20.41749054
92PRKCQ0.40762324
93DDR20.40659698
94MINK10.39763673
95PRKCH0.39277421
96PRKACA0.36039116
97PIK3CA0.35490748
98PRKDC0.32542797
99ALK0.32317950
100PLK20.31771068

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.85771613
2Allograft rejection_Homo sapiens_hsa053302.75976757
3Asthma_Homo sapiens_hsa053102.66588962
4Autoimmune thyroid disease_Homo sapiens_hsa053202.66342539
5Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.51418896
6Graft-versus-host disease_Homo sapiens_hsa053322.41135846
7Maturity onset diabetes of the young_Homo sapiens_hsa049502.40978742
8Type I diabetes mellitus_Homo sapiens_hsa049402.40146295
9Oxidative phosphorylation_Homo sapiens_hsa001902.20313262
10Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.08016404
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.05867042
12Proteasome_Homo sapiens_hsa030502.03512082
13Linoleic acid metabolism_Homo sapiens_hsa005912.02256833
14Butanoate metabolism_Homo sapiens_hsa006501.99994328
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.81577059
16Protein export_Homo sapiens_hsa030601.73380443
17Primary immunodeficiency_Homo sapiens_hsa053401.70405004
18Nitrogen metabolism_Homo sapiens_hsa009101.61311865
19Parkinsons disease_Homo sapiens_hsa050121.60638128
20One carbon pool by folate_Homo sapiens_hsa006701.58124899
21Taste transduction_Homo sapiens_hsa047421.55015354
22RNA degradation_Homo sapiens_hsa030181.54765355
23Phototransduction_Homo sapiens_hsa047441.53828324
24Rheumatoid arthritis_Homo sapiens_hsa053231.46275269
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.42771259
26RNA polymerase_Homo sapiens_hsa030201.36525776
27Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.36309185
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31822133
29Antigen processing and presentation_Homo sapiens_hsa046121.31026502
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26559273
31Fanconi anemia pathway_Homo sapiens_hsa034601.26203776
32Alzheimers disease_Homo sapiens_hsa050101.22402796
33Arachidonic acid metabolism_Homo sapiens_hsa005901.20982836
34Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.20873866
35Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.17604064
36Ether lipid metabolism_Homo sapiens_hsa005651.14237440
37Viral myocarditis_Homo sapiens_hsa054161.13378526
38Morphine addiction_Homo sapiens_hsa050321.12211013
39N-Glycan biosynthesis_Homo sapiens_hsa005101.10982986
40Salivary secretion_Homo sapiens_hsa049701.05569745
41Nicotine addiction_Homo sapiens_hsa050331.04145995
42Chemical carcinogenesis_Homo sapiens_hsa052041.03951663
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03824601
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.03265458
45Olfactory transduction_Homo sapiens_hsa047401.02571608
46Homologous recombination_Homo sapiens_hsa034400.97630174
47Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.97154537
48Non-homologous end-joining_Homo sapiens_hsa034500.96281583
49Propanoate metabolism_Homo sapiens_hsa006400.95782684
50Huntingtons disease_Homo sapiens_hsa050160.94673593
51Steroid hormone biosynthesis_Homo sapiens_hsa001400.92749960
52Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.91683783
53Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.90741155
54Basal transcription factors_Homo sapiens_hsa030220.88620085
55Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.86396183
56Regulation of autophagy_Homo sapiens_hsa041400.85951436
57Insulin secretion_Homo sapiens_hsa049110.85833092
58Hematopoietic cell lineage_Homo sapiens_hsa046400.85759811
59Peroxisome_Homo sapiens_hsa041460.85193547
60Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83370576
61Ovarian steroidogenesis_Homo sapiens_hsa049130.83285273
62Selenocompound metabolism_Homo sapiens_hsa004500.81866041
63Tryptophan metabolism_Homo sapiens_hsa003800.81641428
64Systemic lupus erythematosus_Homo sapiens_hsa053220.81137004
65Ribosome_Homo sapiens_hsa030100.78876372
66Collecting duct acid secretion_Homo sapiens_hsa049660.78715239
67Purine metabolism_Homo sapiens_hsa002300.77457572
68Serotonergic synapse_Homo sapiens_hsa047260.74017558
69Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.72534338
70Circadian entrainment_Homo sapiens_hsa047130.71579488
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.69090605
72Retinol metabolism_Homo sapiens_hsa008300.68125017
73GABAergic synapse_Homo sapiens_hsa047270.66580198
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66504041
75Pyrimidine metabolism_Homo sapiens_hsa002400.64547084
76Cardiac muscle contraction_Homo sapiens_hsa042600.63296854
77RNA transport_Homo sapiens_hsa030130.61466385
78Sphingolipid metabolism_Homo sapiens_hsa006000.58357614
79Calcium signaling pathway_Homo sapiens_hsa040200.56220930
80Caffeine metabolism_Homo sapiens_hsa002320.55974373
81Glutamatergic synapse_Homo sapiens_hsa047240.55826764
82Nucleotide excision repair_Homo sapiens_hsa034200.55683868
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55515144
84Renin secretion_Homo sapiens_hsa049240.55435970
85Staphylococcus aureus infection_Homo sapiens_hsa051500.52413979
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.52081125
87Vitamin digestion and absorption_Homo sapiens_hsa049770.50173183
88Thyroid hormone synthesis_Homo sapiens_hsa049180.49609273
89Sulfur metabolism_Homo sapiens_hsa009200.47313801
90Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45581355
91Metabolic pathways_Homo sapiens_hsa011000.41737067
92ABC transporters_Homo sapiens_hsa020100.41094463
93Pancreatic secretion_Homo sapiens_hsa049720.36345172
94T cell receptor signaling pathway_Homo sapiens_hsa046600.34796731
95Dorso-ventral axis formation_Homo sapiens_hsa043200.33064402
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.32447852
97Fat digestion and absorption_Homo sapiens_hsa049750.31182084
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.29212407
99Dopaminergic synapse_Homo sapiens_hsa047280.27846287
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26815644

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