NHS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing four conserved nuclear localization signals. The encoded protein functions in eye, tooth, craniofacial and brain development, and it can regulate actin remodeling and cell morphology. Mutations in this gene have been shown to cause Nance-Horan syndrome, and also X-linked cataract-40. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)4.40274824
2kidney mesenchyme development (GO:0072074)4.33936384
3metanephric mesenchyme development (GO:0072075)4.25695151
4neuron cell-cell adhesion (GO:0007158)4.00781914
5negative regulation of keratinocyte proliferation (GO:0010839)3.91440942
6paraxial mesoderm development (GO:0048339)3.88958898
7dendritic spine morphogenesis (GO:0060997)3.87842681
8apical protein localization (GO:0045176)3.78555505
9neuron recognition (GO:0008038)3.78372712
10axonal fasciculation (GO:0007413)3.68468384
11regulation of transforming growth factor beta2 production (GO:0032909)3.67201969
12vocalization behavior (GO:0071625)3.58177703
13negative regulation of chondrocyte differentiation (GO:0032331)3.54998824
14cranial nerve morphogenesis (GO:0021602)3.35252943
15sympathetic nervous system development (GO:0048485)3.30507473
16lateral sprouting from an epithelium (GO:0060601)3.28154492
17hippo signaling (GO:0035329)3.23362030
18mesodermal cell differentiation (GO:0048333)3.22503223
19branching involved in salivary gland morphogenesis (GO:0060445)3.21036749
20negative regulation of axon extension involved in axon guidance (GO:0048843)3.20152927
21negative regulation of vascular permeability (GO:0043116)3.17931584
22glomerular epithelial cell development (GO:0072310)3.17718107
23glomerular visceral epithelial cell development (GO:0072015)3.16910679
24positive regulation of synapse assembly (GO:0051965)3.15740543
25dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.13766132
26cell adhesion mediated by integrin (GO:0033627)3.11770140
27head development (GO:0060322)3.10517533
28negative regulation of axon guidance (GO:1902668)3.08335524
29protein localization to synapse (GO:0035418)3.08164940
30regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.05293102
31regulation of axon extension involved in axon guidance (GO:0048841)3.04066387
32presynaptic membrane assembly (GO:0097105)3.02619417
33asymmetric protein localization (GO:0008105)3.02397538
34cell migration in hindbrain (GO:0021535)3.00433923
35regulation of axon guidance (GO:1902667)2.98312366
36neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.98069772
37limb bud formation (GO:0060174)2.97729686
38regulation of non-canonical Wnt signaling pathway (GO:2000050)2.93945142
39regulation of short-term neuronal synaptic plasticity (GO:0048172)2.93266381
40cell migration involved in sprouting angiogenesis (GO:0002042)2.90872174
41layer formation in cerebral cortex (GO:0021819)2.90285026
42dorsal/ventral axis specification (GO:0009950)2.88407490
43short-term memory (GO:0007614)2.86506954
44regulation of synapse assembly (GO:0051963)2.86475693
45substrate-dependent cell migration (GO:0006929)2.86152242
46cranial nerve structural organization (GO:0021604)2.85918803
47postsynaptic membrane organization (GO:0001941)2.83830766
48Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.83135270
49retina vasculature morphogenesis in camera-type eye (GO:0061299)2.81655919
50regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.81168828
51glomerulus development (GO:0032835)2.81016980
52mesenchymal cell differentiation (GO:0048762)2.79659937
53camera-type eye morphogenesis (GO:0048593)2.77701264
54pericardium development (GO:0060039)2.76853277
55regulation of establishment of planar polarity (GO:0090175)2.76657701
56neuron projection extension involved in neuron projection guidance (GO:1902284)2.76270134
57axon extension involved in axon guidance (GO:0048846)2.76270134
58synaptic vesicle exocytosis (GO:0016079)2.76081742
59embryonic foregut morphogenesis (GO:0048617)2.75900369
60regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.75704690
61regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.75521752
62negative regulation of cartilage development (GO:0061037)2.75468716
63notochord development (GO:0030903)2.75358266
64atrial cardiac muscle cell action potential (GO:0086014)2.74783184
65artery development (GO:0060840)2.74129809
66ganglion development (GO:0061548)2.73817321
67regulation of keratinocyte proliferation (GO:0010837)2.70908223
68pre-miRNA processing (GO:0031054)2.70599513
69transmission of nerve impulse (GO:0019226)2.70582659
70regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.70260474
71proline transport (GO:0015824)2.69030227
72presynaptic membrane organization (GO:0097090)2.66168774
73central nervous system projection neuron axonogenesis (GO:0021952)2.65917836
74kidney morphogenesis (GO:0060993)2.65700841
75mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.64497107
76desmosome organization (GO:0002934)2.62229443
77retina layer formation (GO:0010842)2.62164571
78axon extension (GO:0048675)2.62057431
79cilium movement (GO:0003341)2.60877332
80retinal ganglion cell axon guidance (GO:0031290)2.60773763
81establishment of nucleus localization (GO:0040023)2.60303187
82neurotransmitter catabolic process (GO:0042135)2.59141344
83startle response (GO:0001964)2.57749187
84generation of neurons (GO:0048699)2.56941334
85cell surface receptor signaling pathway involved in heart development (GO:0061311)2.56625160
86embryonic retina morphogenesis in camera-type eye (GO:0060059)2.56618729
87righting reflex (GO:0060013)2.56359386
88regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.56190767
89anatomical structure arrangement (GO:0048532)2.53808956
90dendrite development (GO:0016358)2.53669784
91facial nerve structural organization (GO:0021612)2.52233072
92synapse assembly (GO:0007416)2.51505459
93negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.51031420
94negative regulation of translation, ncRNA-mediated (GO:0040033)2.51031420
95regulation of translation, ncRNA-mediated (GO:0045974)2.51031420
96regulation of glutamate receptor signaling pathway (GO:1900449)2.50928417
97mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.50766649
98sensory perception of smell (GO:0007608)2.50452426
99energy coupled proton transport, down electrochemical gradient (GO:0015985)2.49842041
100ATP synthesis coupled proton transport (GO:0015986)2.49842041
101mesenchymal-epithelial cell signaling (GO:0060638)2.49691710
102planar cell polarity pathway involved in neural tube closure (GO:0090179)2.49083698
103establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.48153187
104neural crest cell development (GO:0014032)2.47794582
105extracellular regulation of signal transduction (GO:1900115)2.47622483
106extracellular negative regulation of signal transduction (GO:1900116)2.47622483
107inner ear receptor stereocilium organization (GO:0060122)2.46923544
108axonemal dynein complex assembly (GO:0070286)2.46139033
109neuron projection extension (GO:1990138)2.46118394
110mesenchymal to epithelial transition (GO:0060231)2.45586701
111non-canonical Wnt signaling pathway (GO:0035567)2.44961855
112establishment or maintenance of monopolar cell polarity (GO:0061339)2.44853620
113establishment of monopolar cell polarity (GO:0061162)2.44853620
114positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.44310105
115regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.42397399
116positive regulation of synaptic transmission, GABAergic (GO:0032230)2.42223543
117positive regulation of catenin import into nucleus (GO:0035413)2.42052569
118nodal signaling pathway (GO:0038092)2.40155878
119dendrite morphogenesis (GO:0048813)2.40097004
120forebrain neuron development (GO:0021884)2.39661127
121epithelial cilium movement (GO:0003351)2.37993416
122chondrocyte development (GO:0002063)2.37981855
123positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.37700385
124positive regulation of mesonephros development (GO:0061213)2.37146459
125embryonic body morphogenesis (GO:0010172)2.36767084
126SMAD protein complex assembly (GO:0007183)2.36601818
127cell differentiation involved in kidney development (GO:0061005)2.36522396
128negative regulation of microtubule polymerization (GO:0031115)2.36282669
129central nervous system neuron axonogenesis (GO:0021955)2.35186621
130mesenchymal cell differentiation involved in renal system development (GO:2001012)2.33970162
131mesenchymal cell differentiation involved in kidney development (GO:0072161)2.33970162
132bone trabecula formation (GO:0060346)2.33782568
133establishment of tissue polarity (GO:0007164)2.33383543
134establishment of planar polarity (GO:0001736)2.33383543
135mesenchymal cell development (GO:0014031)2.33263485
136* lens development in camera-type eye (GO:0002088)2.33165935
137regulation of synapse organization (GO:0050807)2.32833608
138bone remodeling (GO:0046849)2.32701553
139endocardial cushion morphogenesis (GO:0003203)2.31781510
140NLS-bearing protein import into nucleus (GO:0006607)2.31719366
141regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.31451642
142negative chemotaxis (GO:0050919)2.31302466
143regulation of mesonephros development (GO:0061217)2.31273968
144mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.30693403
145positive regulation of SMAD protein import into nucleus (GO:0060391)2.30489900
146sequestering of extracellular ligand from receptor (GO:0035581)2.30111148
147morphogenesis of an epithelial sheet (GO:0002011)2.29326530
148auditory receptor cell differentiation (GO:0042491)2.29322089
149positive regulation of gastrulation (GO:2000543)2.28845461
150neuronal ion channel clustering (GO:0045161)2.28613438
151chondrocyte proliferation (GO:0035988)2.28536399
152fibroblast migration (GO:0010761)2.28433545
153body morphogenesis (GO:0010171)2.27767412
154anterior/posterior axis specification, embryo (GO:0008595)2.27540184
155gastrulation with mouth forming second (GO:0001702)2.27030222
156behavioral response to ethanol (GO:0048149)2.26921220
157convergent extension (GO:0060026)2.26856612
158nephron tubule morphogenesis (GO:0072078)2.26564760
159nephron epithelium morphogenesis (GO:0072088)2.26564760
160face morphogenesis (GO:0060325)2.26035639
161polarized epithelial cell differentiation (GO:0030859)2.25912648
162cerebral cortex radially oriented cell migration (GO:0021799)2.25876820
163mating behavior (GO:0007617)2.25596062
164hindlimb morphogenesis (GO:0035137)2.25332978
165innervation (GO:0060384)2.25063685
166maternal behavior (GO:0042711)2.24531244
167mammary gland development (GO:0030879)2.24261476
168chaperone-mediated protein transport (GO:0072321)2.24003235
169regulation of cell fate specification (GO:0042659)2.21577804
170epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.21536200
171collagen fibril organization (GO:0030199)2.21120932
172inner ear receptor cell development (GO:0060119)2.20945715
173establishment or maintenance of bipolar cell polarity (GO:0061245)2.19980351
174establishment or maintenance of apical/basal cell polarity (GO:0035088)2.19980351
175mitotic sister chromatid cohesion (GO:0007064)2.19474390

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.29074130
2TP63_17297297_ChIP-ChIP_HaCaT_Human3.34176874
3GBX2_23144817_ChIP-Seq_PC3_Human3.30226828
4EZH2_27304074_Chip-Seq_ESCs_Mouse2.83752866
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.81042434
6GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.75068791
7EED_16625203_ChIP-ChIP_MESCs_Mouse2.64289239
8BMI1_23680149_ChIP-Seq_NPCS_Mouse2.62504393
9* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.58914747
10SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.57696631
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.55803591
12EZH2_18974828_ChIP-Seq_MESCs_Mouse2.55803591
13CBX2_27304074_Chip-Seq_ESCs_Mouse2.46801485
14TAF15_26573619_Chip-Seq_HEK293_Human2.44725888
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.38605821
16* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.37809022
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.32565862
18SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.25337188
19RBPJ_22232070_ChIP-Seq_NCS_Mouse2.19701622
20BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.12013925
21PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.09118936
22RNF2_27304074_Chip-Seq_NSC_Mouse2.03162784
23SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.02942229
24HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.02664966
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.02432283
26CTBP2_25329375_ChIP-Seq_LNCAP_Human2.02099500
27FUS_26573619_Chip-Seq_HEK293_Human2.02069160
28ZFP57_27257070_Chip-Seq_ESCs_Mouse1.92433367
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91113939
30RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.90289183
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.88273908
32AR_21572438_ChIP-Seq_LNCaP_Human1.85000305
33* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84304998
34* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.84028847
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82665226
36* P300_19829295_ChIP-Seq_ESCs_Human1.81662180
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.80593060
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.79458594
39SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79148650
40PIAS1_25552417_ChIP-Seq_VCAP_Human1.78762466
41TOP2B_26459242_ChIP-Seq_MCF-7_Human1.74772681
42* TP53_16413492_ChIP-PET_HCT116_Human1.73574386
43* CJUN_26792858_Chip-Seq_BT549_Human1.72380459
44* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.70847399
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.70794351
46* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.70401831
47SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.69485418
48ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69154303
49NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.67641933
50POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67056291
51CTNNB1_20460455_ChIP-Seq_HCT116_Human1.64112484
52GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.57747853
53* SMAD4_21799915_ChIP-Seq_A2780_Human1.56422507
54CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.55607958
55NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.55202971
56IGF1R_20145208_ChIP-Seq_DFB_Human1.54167201
57TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.53345929
58CDX2_19796622_ChIP-Seq_MESCs_Mouse1.53338433
59EWS_26573619_Chip-Seq_HEK293_Human1.52189649
60SMAD3_21741376_ChIP-Seq_EPCs_Human1.51977695
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.50875712
62BRD4_25478319_ChIP-Seq_HGPS_Human1.49896089
63EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.45176509
64FOXM1_23109430_ChIP-Seq_U2OS_Human1.44674094
65WT1_19549856_ChIP-ChIP_CCG9911_Human1.43136707
66VDR_22108803_ChIP-Seq_LS180_Human1.42748970
67OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.42381404
68* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.41026988
69* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.38305684
70TP63_19390658_ChIP-ChIP_HaCaT_Human1.36574971
71NRF2_20460467_ChIP-Seq_MEFs_Mouse1.35762689
72NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.35762689
73* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.35647157
74RING1B_27294783_Chip-Seq_NPCs_Mouse1.35239001
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.34964182
76RING1B_27294783_Chip-Seq_ESCs_Mouse1.34599264
77ZNF274_21170338_ChIP-Seq_K562_Hela1.33755739
78REST_21632747_ChIP-Seq_MESCs_Mouse1.33076837
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32375139
80SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.30755076
81* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.29236498
82* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.29236498
83SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28276284
84SMAD3_21741376_ChIP-Seq_HESCs_Human1.27463130
85* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.27260991
86UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.26219086
87* TP53_18474530_ChIP-ChIP_U2OS_Human1.26118677
88TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25008549
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.24922049
90FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.24834637
91CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.24565054
92PPAR_26484153_Chip-Seq_NCI-H1993_Human1.24014689
93TCF4_18268006_ChIP-ChIP_LS174T_Human1.22049492
94ZNF217_24962896_ChIP-Seq_MCF-7_Human1.21331274
95TBX3_20139965_ChIP-Seq_ESCs_Mouse1.21058326
96TBX3_20139965_ChIP-Seq_MESCs_Mouse1.20882350
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.19898737
98POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.19383981
99TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19383981
100AR_25329375_ChIP-Seq_VCAP_Human1.19311426
101CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.19172915
102* RUNX2_22187159_ChIP-Seq_PCA_Human1.18874092
103ER_23166858_ChIP-Seq_MCF-7_Human1.17560430
104SMAD_19615063_ChIP-ChIP_OVARY_Human1.17414778
105HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.16798254
106TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14988865
107WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13626220
108* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.13340892
109TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12333528
110* SMAD4_21741376_ChIP-Seq_HESCs_Human1.11378572
111KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.11265247
112PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.10887018
113* TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.10203023
114TRIM28_21343339_ChIP-Seq_HEK293_Human1.10062368
115TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09926423
116MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.09807026
117TP53_20018659_ChIP-ChIP_R1E_Mouse1.09368028
118YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08785192
119* TP63_23658742_ChIP-Seq_EP156T_Human1.08701649
120* ARNT_22903824_ChIP-Seq_MCF-7_Human1.07789709
121* SOX2_21211035_ChIP-Seq_LN229_Gbm1.06943418
122KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.06421340
123* P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06095577
124FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.05880223
125DROSHA_22980978_ChIP-Seq_HELA_Human1.05799850
126NANOG_18555785_Chip-Seq_ESCs_Mouse1.05678183
127BCAT_22108803_ChIP-Seq_LS180_Human1.05099903
128EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04929928
129STAT3_23295773_ChIP-Seq_U87_Human1.04691705
130FOXO3_23340844_ChIP-Seq_DLD1_Human1.04656679
131AR_21909140_ChIP-Seq_LNCAP_Human1.03797193
132AHR_22903824_ChIP-Seq_MCF-7_Human1.03694781
133JUN_21703547_ChIP-Seq_K562_Human1.01801335
134FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99996886
135TCF4_23295773_ChIP-Seq_U87_Human0.99801812
136* ISL1_27105846_Chip-Seq_CPCs_Mouse0.99143881
137STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.97588295
138PCGF2_27294783_Chip-Seq_ESCs_Mouse0.97066148
139EP300_21415370_ChIP-Seq_HL-1_Mouse0.95992871
140PRDM14_20953172_ChIP-Seq_ESCs_Human0.95644280

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000579_abnormal_nail_morphology3.45565562
2MP0003122_maternal_imprinting2.90923823
3MP0000569_abnormal_digit_pigmentation2.88196437
4MP0003705_abnormal_hypodermis_morpholog2.50429139
5MP0008789_abnormal_olfactory_epithelium2.35866362
6MP0008438_abnormal_cutaneous_collagen2.33602086
7MP0003880_abnormal_central_pattern2.32698879
8MP0006276_abnormal_autonomic_nervous2.26332022
9MP0001188_hyperpigmentation2.26311421
10MP0010030_abnormal_orbit_morphology2.25674790
11MP0005275_abnormal_skin_tensile2.19819573
12MP0010678_abnormal_skin_adnexa2.18609470
13MP0003385_abnormal_body_wall2.18461766
14MP0000383_abnormal_hair_follicle2.15708206
15MP0000778_abnormal_nervous_system2.11694216
16MP0005394_taste/olfaction_phenotype2.05196147
17MP0005499_abnormal_olfactory_system2.05196147
18MP0005423_abnormal_somatic_nervous1.98944500
19MP0003121_genomic_imprinting1.96627705
20MP0001984_abnormal_olfaction1.93820064
21MP0002102_abnormal_ear_morphology1.85483789
22MP0003942_abnormal_urinary_system1.83094458
23MP0009250_abnormal_appendicular_skeleto1.83034515
24MP0002184_abnormal_innervation1.79114653
25MP0000049_abnormal_middle_ear1.76676272
26MP0003635_abnormal_synaptic_transmissio1.75094268
27MP0003123_paternal_imprinting1.74958666
28MP0003787_abnormal_imprinting1.71800868
29MP0010352_gastrointestinal_tract_polyps1.65655804
30MP0002734_abnormal_mechanical_nocicepti1.65516644
31MP0003566_abnormal_cell_adhesion1.62069613
32MP0005257_abnormal_intraocular_pressure1.61662597
33MP0004859_abnormal_synaptic_plasticity1.61441590
34MP0000566_synostosis1.60894664
35MP0001486_abnormal_startle_reflex1.60820272
36MP0000534_abnormal_ureter_morphology1.60514587
37MP0000537_abnormal_urethra_morphology1.60037455
38MP0009780_abnormal_chondrocyte_physiolo1.59974369
39MP0009379_abnormal_foot_pigmentation1.59717363
40MP0000428_abnormal_craniofacial_morphol1.55799245
41MP0001485_abnormal_pinna_reflex1.55176954
42MP0002938_white_spotting1.54808758
43MP0000427_abnormal_hair_cycle1.51278693
44MP0004270_analgesia1.50854259
45MP0002249_abnormal_larynx_morphology1.49837543
46MP0009745_abnormal_behavioral_response1.48891356
47MP0002233_abnormal_nose_morphology1.48866363
48MP0005248_abnormal_Harderian_gland1.48821878
49MP0010386_abnormal_urinary_bladder1.47863403
50MP0005076_abnormal_cell_differentiation1.45957668
51MP0003755_abnormal_palate_morphology1.44941279
52MP0003115_abnormal_respiratory_system1.44168710
53MP0003937_abnormal_limbs/digits/tail_de1.44098179
54MP0001968_abnormal_touch/_nociception1.43576827
55MP0001346_abnormal_lacrimal_gland1.42787273
56MP0002697_abnormal_eye_size1.42537293
57MP0009046_muscle_twitch1.42368468
58MP0002557_abnormal_social/conspecific_i1.41708190
59MP0002751_abnormal_autonomic_nervous1.41118521
60MP0000631_abnormal_neuroendocrine_gland1.40804998
61MP0000432_abnormal_head_morphology1.40129182
62MP0002063_abnormal_learning/memory/cond1.39862879
63MP0002572_abnormal_emotion/affect_behav1.38731564
64MP0003283_abnormal_digestive_organ1.38154743
65MP0002163_abnormal_gland_morphology1.36740817
66MP0000026_abnormal_inner_ear1.36406853
67MP0002060_abnormal_skin_morphology1.35057278
68MP0002735_abnormal_chemical_nociception1.34244291
69MP0002064_seizures1.34054584
70MP0003938_abnormal_ear_development1.33493159
71MP0003941_abnormal_skin_development1.33173487
72MP0005503_abnormal_tendon_morphology1.31177130
73MP0001849_ear_inflammation1.28986504
74MP0005645_abnormal_hypothalamus_physiol1.27667983
75MP0004272_abnormal_basement_membrane1.27643124
76MP0005508_abnormal_skeleton_morphology1.25330829
77MP0005367_renal/urinary_system_phenotyp1.24185974
78MP0000516_abnormal_urinary_system1.24185974
79MP0002822_catalepsy1.23649195
80MP0002272_abnormal_nervous_system1.23081920
81MP0000467_abnormal_esophagus_morphology1.22771591
82MP0002067_abnormal_sensory_capabilities1.22321454
83MP0006292_abnormal_olfactory_placode1.21636882
84MP0009053_abnormal_anal_canal1.21590050
85MP0006072_abnormal_retinal_apoptosis1.19554890
86MP0002752_abnormal_somatic_nervous1.19368608
87MP0003091_abnormal_cell_migration1.16879959
88MP0004742_abnormal_vestibular_system1.16070192
89MP0002084_abnormal_developmental_patter1.15110338
90MP0001529_abnormal_vocalization1.15052980
91MP0002882_abnormal_neuron_morphology1.14423130
92MP0001963_abnormal_hearing_physiology1.12980902
93MP0000762_abnormal_tongue_morphology1.12552058
94MP0003119_abnormal_digestive_system1.12389425
95MP0002116_abnormal_craniofacial_bone1.11862681
96MP0000462_abnormal_digestive_system1.11357427
97MP0005409_darkened_coat_color1.11112819
98* MP0001286_abnormal_eye_development1.10930664
99MP0003315_abnormal_perineum_morphology1.09148352
100MP0003861_abnormal_nervous_system1.08614306
101MP0005623_abnormal_meninges_morphology1.08514515
102MP0002282_abnormal_trachea_morphology1.07817630
103MP0002092_abnormal_eye_morphology1.07746349
104MP0002638_abnormal_pupillary_reflex1.07502867
105MP0005197_abnormal_uvea_morphology1.06486182
106MP0000647_abnormal_sebaceous_gland1.05744181
107MP0002932_abnormal_joint_morphology1.04544607
108MP0009703_decreased_birth_body1.04032299
109MP0005646_abnormal_pituitary_gland1.03123967
110MP0009384_cardiac_valve_regurgitation1.03033312
111MP0005023_abnormal_wound_healing1.02413915
112MP0000955_abnormal_spinal_cord1.02089850
113MP0003890_abnormal_embryonic-extraembry1.01857051
114MP0001970_abnormal_pain_threshold1.01708423
115MP0000538_abnormal_urinary_bladder1.00143253
116MP0002152_abnormal_brain_morphology0.99089159
117MP0001440_abnormal_grooming_behavior0.98952095
118MP0001299_abnormal_eye_distance/0.98841358
119MP0002177_abnormal_outer_ear0.97884718
120MP0005386_behavior/neurological_phenoty0.97733736
121MP0004924_abnormal_behavior0.97733736
122MP0002733_abnormal_thermal_nociception0.97259572
123MP0010234_abnormal_vibrissa_follicle0.96742663
124MP0003950_abnormal_plasma_membrane0.96656868
125MP0003935_abnormal_craniofacial_develop0.95087385
126MP0002009_preneoplasia0.94950989
127MP0005551_abnormal_eye_electrophysiolog0.93852103
128MP0001958_emphysema0.92926036
129MP0002111_abnormal_tail_morphology0.92530123
130MP0002085_abnormal_embryonic_tissue0.92064853
131MP0008057_abnormal_DNA_replication0.92007425
132MP0003453_abnormal_keratinocyte_physiol0.91644549
133MP0002081_perinatal_lethality0.91463208
134MP0002234_abnormal_pharynx_morphology0.91157787
135MP0001340_abnormal_eyelid_morphology0.90513361
136MP0002109_abnormal_limb_morphology0.90155457
137MP0005377_hearing/vestibular/ear_phenot0.88596550
138MP0003878_abnormal_ear_physiology0.88596550
139MP0005171_absent_coat_pigmentation0.88323457
140MP0001177_atelectasis0.87932492
141MP0004133_heterotaxia0.87711443
142MP0001293_anophthalmia0.87595078
143MP0002896_abnormal_bone_mineralization0.87358328
144MP0002796_impaired_skin_barrier0.86108526
145MP0004197_abnormal_fetal_growth/weight/0.85007890
146MP0010771_integument_phenotype0.81888442
147MP0002098_abnormal_vibrissa_morphology0.80487597
148MP0002925_abnormal_cardiovascular_devel0.75555255
149MP0002108_abnormal_muscle_morphology0.75007655
150MP0000377_abnormal_hair_follicle0.74312796
151MP0000163_abnormal_cartilage_morphology0.73861216
152MP0001216_abnormal_epidermal_layer0.73604253
153MP0006054_spinal_hemorrhage0.73143046
154MP0002114_abnormal_axial_skeleton0.73030902

Predicted human phenotypes

RankGene SetZ-score
1Atrophic scars (HP:0001075)3.35868971
2Arterial tortuosity (HP:0005116)3.35320443
3Morphological abnormality of the middle ear (HP:0008609)3.33339680
4* Zonular cataract (HP:0010920)3.25075516
5* Nuclear cataract (HP:0100018)3.21000161
6Vascular tortuosity (HP:0004948)2.91538632
7Midline defect of the nose (HP:0004122)2.86749185
8Aortic dissection (HP:0002647)2.83962654
9Absent frontal sinuses (HP:0002688)2.78464852
10Hypothermia (HP:0002045)2.77725092
11Cutaneous finger syndactyly (HP:0010554)2.61302290
12Amblyopia (HP:0000646)2.61117741
13Vertebral arch anomaly (HP:0008438)2.58937880
14Focal motor seizures (HP:0011153)2.58399836
15Premature rupture of membranes (HP:0001788)2.57335791
16Abnormality of the nasolacrimal system (HP:0000614)2.53887434
17Limb dystonia (HP:0002451)2.53284895
18Hyperkalemia (HP:0002153)2.52948685
19Genital tract atresia (HP:0001827)2.52606171
20Hyperactive renin-angiotensin system (HP:0000841)2.50610061
21Coronal craniosynostosis (HP:0004440)2.48388924
22Vaginal atresia (HP:0000148)2.46108082
23Aplasia cutis congenita (HP:0001057)2.46055007
24Fragile skin (HP:0001030)2.44888924
25Anophthalmia (HP:0000528)2.43991464
26Abnormality of the lacrimal duct (HP:0011481)2.43672489
27Absent eyebrow (HP:0002223)2.43175087
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.42738019
29Broad metatarsal (HP:0001783)2.39919293
30Hepatoblastoma (HP:0002884)2.38533620
31Gait imbalance (HP:0002141)2.37425442
32Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.35900944
33Milia (HP:0001056)2.34288077
34Atonic seizures (HP:0010819)2.33875682
35Congenital primary aphakia (HP:0007707)2.32930648
36Hypoplastic labia majora (HP:0000059)2.29909120
37Short nail (HP:0001799)2.29597880
38Febrile seizures (HP:0002373)2.29189599
39Myelomeningocele (HP:0002475)2.27299054
40Esophageal atresia (HP:0002032)2.26436261
41Cutaneous syndactyly (HP:0012725)2.24558376
42Bifid tongue (HP:0010297)2.23256781
43Pterygium (HP:0001059)2.22036564
44Fibular aplasia (HP:0002990)2.19439556
45Protrusio acetabuli (HP:0003179)2.17980792
46Renal hypoplasia (HP:0000089)2.17472879
47Selective tooth agenesis (HP:0001592)2.16593832
48Rhinitis (HP:0012384)2.15956539
49Exotropia (HP:0000577)2.15063075
50Abnormal ciliary motility (HP:0012262)2.14844926
51Chorioretinal atrophy (HP:0000533)2.13024836
52Preaxial foot polydactyly (HP:0001841)2.12073752
53Bilateral microphthalmos (HP:0007633)2.12062379
54Asymmetry of the thorax (HP:0001555)2.11405848
55Abnormality of dentin (HP:0010299)2.06978505
56Aortic aneurysm (HP:0004942)2.05540387
57Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.04935118
58Short 4th metacarpal (HP:0010044)2.04935118
59Broad-based gait (HP:0002136)2.03691556
60Focal seizures (HP:0007359)2.03342663
61Increased circulating renin level (HP:0000848)2.03154928
62Myokymia (HP:0002411)2.02862630
63Shallow orbits (HP:0000586)2.01571897
64Abnormality of the nasal septum (HP:0000419)2.01435228
65Oligodactyly (hands) (HP:0001180)2.01285559
66Medial flaring of the eyebrow (HP:0010747)2.00613815
67Abnormality of the labia majora (HP:0012881)2.00561333
68Labial hypoplasia (HP:0000066)1.99978923
69Abnormal hair whorl (HP:0010721)1.99718347
70Aplasia involving bones of the extremities (HP:0009825)1.99168528
71Aplasia involving bones of the upper limbs (HP:0009823)1.99168528
72Aplasia of the phalanges of the hand (HP:0009802)1.99168528
73Ankyloglossia (HP:0010296)1.98802453
74Volvulus (HP:0002580)1.97520299
75Papillary thyroid carcinoma (HP:0002895)1.95066699
76Osteolytic defects of the hand bones (HP:0009699)1.92957184
77Osteolytic defects of the phalanges of the hand (HP:0009771)1.92957184
78Fragile nails (HP:0001808)1.90716320
79Abnormality of the frontal sinuses (HP:0002687)1.90338784
80Abnormality of midbrain morphology (HP:0002418)1.88356193
81Molar tooth sign on MRI (HP:0002419)1.88356193
82Nephrogenic diabetes insipidus (HP:0009806)1.88332917
83Hyperthyroidism (HP:0000836)1.88107213
84Abnormality of the right ventricle (HP:0001707)1.87835892
85Aplasia/Hypoplasia of the tibia (HP:0005772)1.87486104
86Septo-optic dysplasia (HP:0100842)1.87002070
87Mitral valve prolapse (HP:0001634)1.86810267
88Renal dysplasia (HP:0000110)1.86579755
89Aplasia/Hypoplasia of the lens (HP:0008063)1.86567691
90Progressive cerebellar ataxia (HP:0002073)1.86114225
91Shawl scrotum (HP:0000049)1.85289343
92Bell-shaped thorax (HP:0001591)1.85046693
93Omphalocele (HP:0001539)1.85012449
94Embryonal renal neoplasm (HP:0011794)1.84901971
95Hyperventilation (HP:0002883)1.84786331
96Narrow nasal bridge (HP:0000446)1.84723350
97Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.84222105
98Abnormality of the labia minora (HP:0012880)1.83798972
99Abnormality of the distal phalanx of the thumb (HP:0009617)1.83372262
100Chronic bronchitis (HP:0004469)1.81923217
101Cervical subluxation (HP:0003308)1.81591244
102Progressive macrocephaly (HP:0004481)1.80895516
103Soft skin (HP:0000977)1.80468152
104Hypoplastic female external genitalia (HP:0012815)1.80350417
105Acute necrotizing encephalopathy (HP:0006965)1.78675987
106Nephroblastoma (Wilms tumor) (HP:0002667)1.78566645
107Abnormality of the renal medulla (HP:0100957)1.77186775
108Anterior segment dysgenesis (HP:0007700)1.76559606
109Ulnar bowing (HP:0003031)1.75814237
110Abnormal respiratory motile cilium morphology (HP:0005938)1.75500970
111Abnormal respiratory epithelium morphology (HP:0012253)1.75500970
112Hypoplasia of dental enamel (HP:0006297)1.74884983
113Tracheomalacia (HP:0002779)1.74849160
114Abnormality of oral frenula (HP:0000190)1.73731120
115Sclerocornea (HP:0000647)1.73439160
116Short tibia (HP:0005736)1.72823401
117Bicornuate uterus (HP:0000813)1.72324437
118Broad long bones (HP:0005622)1.72206378
119Nasolacrimal duct obstruction (HP:0000579)1.70981508
120Abnormality of abdominal situs (HP:0011620)1.70797954
121Abdominal situs inversus (HP:0003363)1.70797954
122Aplasia/Hypoplasia of the sternum (HP:0006714)1.70544728
123Agitation (HP:0000713)1.69186563
124Buphthalmos (HP:0000557)1.69010107
125Abnormality of the parietal bone (HP:0002696)1.69002125
126Pulmonic stenosis (HP:0001642)1.68945831
127Renal duplication (HP:0000075)1.67769490
128Abnormal respiratory motile cilium physiology (HP:0012261)1.67544041
129Nephronophthisis (HP:0000090)1.67137740
130Aqueductal stenosis (HP:0002410)1.66917768
131Natal tooth (HP:0000695)1.66322613
132High anterior hairline (HP:0009890)1.65473793
133Syringomyelia (HP:0003396)1.65045750
134Spinal cord lesions (HP:0100561)1.65045750
135Abnormality of the ischium (HP:0003174)1.64559568
136Oligodactyly (HP:0012165)1.64498204
137Broad thumb (HP:0011304)1.64242482
138Short metatarsal (HP:0010743)1.64170988
139Arnold-Chiari malformation (HP:0002308)1.63980069
140Tented upper lip vermilion (HP:0010804)1.63972105
141Corneal dystrophy (HP:0001131)1.63007614
142Abnormality of the antihelix (HP:0009738)1.62979271
143Drooling (HP:0002307)1.62655287
144Excessive salivation (HP:0003781)1.62655287
145Abnormality of molar morphology (HP:0011070)1.62506573
146Abnormality of molar (HP:0011077)1.62506573
147Abnormality of permanent molar morphology (HP:0011071)1.61774967
148Abnormality of the dental root (HP:0006486)1.61774967
149Taurodontia (HP:0000679)1.61774967
150Bronchomalacia (HP:0002780)1.61588072
151Wide anterior fontanel (HP:0000260)1.60761174
152Pancreatic fibrosis (HP:0100732)1.60000222
153Supernumerary ribs (HP:0005815)1.59931149
154Absent/shortened dynein arms (HP:0200106)1.59644830
155Dynein arm defect of respiratory motile cilia (HP:0012255)1.59644830
156Broad face (HP:0000283)1.58652900
157Round face (HP:0000311)1.58034170
158Protruding tongue (HP:0010808)1.57639049
159Abnormal vertebral ossification (HP:0100569)1.57582511
160Aplasia/Hypoplasia of metatarsal bones (HP:0001964)1.56647381
161Broad toe (HP:0001837)1.56553639
162Turricephaly (HP:0000262)1.56458333
163Broad phalanx (HP:0006009)1.56192781
164Absence seizures (HP:0002121)1.56143490
165Long eyelashes (HP:0000527)1.56032865
166Specific learning disability (HP:0001328)1.56024857
167Preaxial hand polydactyly (HP:0001177)1.55154462
168True hermaphroditism (HP:0010459)1.54933253
169Fibular hypoplasia (HP:0003038)1.54480389
170Hypoventilation (HP:0002791)1.54386883
171Abnormality of the phalanges of the hallux (HP:0010057)1.53283240
172Microglossia (HP:0000171)1.53233718
173Aplasia/Hypoplasia of the brainstem (HP:0007362)1.53035802
174Hypoplasia of the brainstem (HP:0002365)1.53035802
175Humeroradial synostosis (HP:0003041)1.52980932
176Synostosis involving the elbow (HP:0003938)1.52980932
177Overgrowth (HP:0001548)1.52593702
178Hypoplastic left heart (HP:0004383)1.52572475

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST1R4.55871717
2CASK3.89936870
3MARK13.17961964
4PNCK3.15443962
5MET2.97081330
6NTRK32.78835900
7EPHA22.58836240
8MAP3K42.56918844
9MAPK132.56838037
10NTRK22.53165678
11MAP2K72.36244397
12TNIK2.18602105
13EPHB22.12708036
14BMPR1B2.06741025
15ERBB32.02400935
16SRPK11.97689035
17STK31.82451173
18FRK1.82380325
19STK241.73412321
20LATS21.70397227
21MAP3K121.68710591
22PLK21.65338845
23MKNK21.60244974
24MINK11.59937824
25CAMK1D1.54884714
26BCR1.48746646
27DYRK21.45840717
28PTK21.45813769
29LMTK21.40412103
30MKNK11.38321156
31PDGFRA1.38252229
32AKT31.35879707
33NTRK11.30921032
34MELK1.27715855
35PAK31.25783247
36UHMK11.25250157
37FGFR21.24838961
38PDGFRB1.23182329
39CSNK1G21.22779798
40DMPK1.21807357
41CSNK1A1L1.21544226
42CSNK1G31.20285172
43EPHA41.19463138
44DDR21.17151902
45NME11.15865276
46CDK121.15046285
47LIMK11.14741342
48WNK41.14375473
49WNK31.14360898
50FGFR11.11939441
51SGK21.09688080
52PRPF4B1.07522159
53WEE11.05822323
54PHKG21.05212015
55PHKG11.05212015
56SGK2231.03700734
57SGK4941.03700734
58CSNK1G11.02306205
59MAP2K40.98247529
60YES10.97863789
61STK390.97084443
62BRSK20.97058745
63PRKD30.95583134
64ROCK10.94739463
65TTN0.94441315
66LATS10.94359833
67ERBB40.94123228
68OXSR10.93841756
69ADRBK10.93282335
70NLK0.92826980
71FER0.91317221
72NEK20.90630715
73STK38L0.89615279
74WNK10.89366611
75PLK30.87109813
76EPHA30.84310174
77KSR10.83921589
78GRK50.81927720
79SIK10.81470575
80CAMK1G0.80789482
81DYRK1A0.80137519
82CDK80.79715428
83PRKCE0.77865773
84MTOR0.76748225
85CDK30.75384709
86CDC70.75041685
87PKN10.74644582
88ZAK0.73045641
89PDK20.72256768
90CDC42BPA0.70086313
91CAMK2A0.69384916
92BRD40.69280328
93PAK40.67898431
94SIK20.67830462
95NEK90.67085346
96TTK0.66845303
97ROCK20.66270926
98TSSK60.65990855
99PAK20.65766683
100ADRBK20.65107208
101SGK10.63892708
102STK100.61859865
103TGFBR10.61170499
104PRKCG0.60903242
105CDK50.60238636
106SIK30.58476225
107CAMK2B0.56769471
108ICK0.55967154
109PBK0.53343037
110MAP3K70.51321379
111CSNK1E0.50294123
112STK110.49369181
113PLK40.49166089
114PTK2B0.48635428
115GRK70.48436216
116CHEK20.48113397
117TLK10.46027139
118MAP3K20.45645078
119PRKG10.44164317
120ERBB20.43595207
121MYLK0.43500209
122EIF2AK20.42269799
123MAPK150.42163944
124DAPK20.42153057
125NUAK10.41832725
126SGK30.41088036
127TGFBR20.40270076
128CDK180.39722071
129CDK140.38968886
130BMX0.38891441
131TAF10.38832618
132DYRK30.37598313
133BMPR20.37557837
134CAMK2D0.37484994
135MAP3K90.37230737
136PRKCZ0.37114613
137NEK60.37082614
138MAP2K60.36001691
139IRAK20.35252092
140STK380.34992342
141PRKCB0.34208859
142AURKA0.34125590
143RIPK10.31410493
144MST40.29127456

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.19791232
2Oxidative phosphorylation_Homo sapiens_hsa001902.51390803
3Olfactory transduction_Homo sapiens_hsa047402.37688278
4Synaptic vesicle cycle_Homo sapiens_hsa047212.23344320
5Phototransduction_Homo sapiens_hsa047442.21275278
6Taste transduction_Homo sapiens_hsa047422.14562470
7Axon guidance_Homo sapiens_hsa043602.10851343
8Parkinsons disease_Homo sapiens_hsa050122.09337449
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.99416293
10Collecting duct acid secretion_Homo sapiens_hsa049661.92135386
11GABAergic synapse_Homo sapiens_hsa047271.84157984
12Serotonergic synapse_Homo sapiens_hsa047261.83047530
13Hedgehog signaling pathway_Homo sapiens_hsa043401.77185453
14Basal cell carcinoma_Homo sapiens_hsa052171.73707516
15Alzheimers disease_Homo sapiens_hsa050101.72310855
16Huntingtons disease_Homo sapiens_hsa050161.68609258
17Morphine addiction_Homo sapiens_hsa050321.67000328
18Glutamatergic synapse_Homo sapiens_hsa047241.62935313
19Dopaminergic synapse_Homo sapiens_hsa047281.61301870
20Amphetamine addiction_Homo sapiens_hsa050311.59863179
21Circadian entrainment_Homo sapiens_hsa047131.59106750
22Cardiac muscle contraction_Homo sapiens_hsa042601.54821931
23Long-term depression_Homo sapiens_hsa047301.54405115
24Cholinergic synapse_Homo sapiens_hsa047251.48988663
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.48248987
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.44601218
27Melanogenesis_Homo sapiens_hsa049161.44521069
28Cocaine addiction_Homo sapiens_hsa050301.43204115
29Renin secretion_Homo sapiens_hsa049241.41352947
30Long-term potentiation_Homo sapiens_hsa047201.40412275
31Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.39651512
32Wnt signaling pathway_Homo sapiens_hsa043101.39026069
33Amoebiasis_Homo sapiens_hsa051461.38915173
34Small cell lung cancer_Homo sapiens_hsa052221.35948583
35Notch signaling pathway_Homo sapiens_hsa043301.34148780
36Vibrio cholerae infection_Homo sapiens_hsa051101.34016286
37Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.30720452
38Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.30585210
39Hippo signaling pathway_Homo sapiens_hsa043901.27866051
40Melanoma_Homo sapiens_hsa052181.26443457
41Insulin secretion_Homo sapiens_hsa049111.20921731
42Gap junction_Homo sapiens_hsa045401.20582373
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.20251340
44Gastric acid secretion_Homo sapiens_hsa049711.12554090
45Thyroid cancer_Homo sapiens_hsa052161.10939432
46Salivary secretion_Homo sapiens_hsa049701.09380164
47GnRH signaling pathway_Homo sapiens_hsa049121.08395410
48Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.06711152
49Dilated cardiomyopathy_Homo sapiens_hsa054141.05645720
50Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01259999
51Oxytocin signaling pathway_Homo sapiens_hsa049211.01163041
52Circadian rhythm_Homo sapiens_hsa047101.00465188
53TGF-beta signaling pathway_Homo sapiens_hsa043500.99976549
54Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.99954877
55Calcium signaling pathway_Homo sapiens_hsa040200.97863500
56Chronic myeloid leukemia_Homo sapiens_hsa052200.96957022
57Oocyte meiosis_Homo sapiens_hsa041140.96518802
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96200188
59ErbB signaling pathway_Homo sapiens_hsa040120.94593110
60Glioma_Homo sapiens_hsa052140.93170787
61AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91836356
62Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.89779536
63Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.89132374
64ECM-receptor interaction_Homo sapiens_hsa045120.88562386
65Central carbon metabolism in cancer_Homo sapiens_hsa052300.87940306
66Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.87805983
67Estrogen signaling pathway_Homo sapiens_hsa049150.87797763
68Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87465137
69Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87041831
70Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.86880446
71Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.85142954
72Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.84645137
73Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.84373102
74Alcoholism_Homo sapiens_hsa050340.83581854
75Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81766812
76Non-homologous end-joining_Homo sapiens_hsa034500.81390064
77Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80878826
78Dorso-ventral axis formation_Homo sapiens_hsa043200.80320607
79cAMP signaling pathway_Homo sapiens_hsa040240.79710452
80Ovarian steroidogenesis_Homo sapiens_hsa049130.78297931
81Cell cycle_Homo sapiens_hsa041100.77815283
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76687422
83Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.75791908
84Tight junction_Homo sapiens_hsa045300.75719571
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.75670442
86Inositol phosphate metabolism_Homo sapiens_hsa005620.75652105
87Pancreatic cancer_Homo sapiens_hsa052120.75537617
88Adherens junction_Homo sapiens_hsa045200.74080093
89Lysine degradation_Homo sapiens_hsa003100.73540050
90Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72532783
91Colorectal cancer_Homo sapiens_hsa052100.72436903
92Endometrial cancer_Homo sapiens_hsa052130.71092396
93Ras signaling pathway_Homo sapiens_hsa040140.71055805
94MAPK signaling pathway_Homo sapiens_hsa040100.69755392
95Rap1 signaling pathway_Homo sapiens_hsa040150.69642802
96Sphingolipid metabolism_Homo sapiens_hsa006000.68656367
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.67742367
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.67245539
99Leukocyte transendothelial migration_Homo sapiens_hsa046700.65414003
100p53 signaling pathway_Homo sapiens_hsa041150.64886791
101Vitamin B6 metabolism_Homo sapiens_hsa007500.63447534
102Prostate cancer_Homo sapiens_hsa052150.63069530
103FoxO signaling pathway_Homo sapiens_hsa040680.62766294
104Pathways in cancer_Homo sapiens_hsa052000.62028590
105mRNA surveillance pathway_Homo sapiens_hsa030150.61561546
106Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60595634
107Renal cell carcinoma_Homo sapiens_hsa052110.58186709
108Nitrogen metabolism_Homo sapiens_hsa009100.57053867
109Type II diabetes mellitus_Homo sapiens_hsa049300.56224522
110MicroRNAs in cancer_Homo sapiens_hsa052060.56137255
111Vascular smooth muscle contraction_Homo sapiens_hsa042700.55695867
112Focal adhesion_Homo sapiens_hsa045100.53993922
113Steroid biosynthesis_Homo sapiens_hsa001000.53612790
114Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53577233
115Glucagon signaling pathway_Homo sapiens_hsa049220.50210450
116Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.49815506
117Thyroid hormone synthesis_Homo sapiens_hsa049180.48093052
118Protein digestion and absorption_Homo sapiens_hsa049740.46684299
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.45921559
120Phagosome_Homo sapiens_hsa041450.45658886
121Endocytosis_Homo sapiens_hsa041440.45630889
122PI3K-Akt signaling pathway_Homo sapiens_hsa041510.45005966
123Proteoglycans in cancer_Homo sapiens_hsa052050.44398366
124Neurotrophin signaling pathway_Homo sapiens_hsa047220.44268062
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42743788
126Rheumatoid arthritis_Homo sapiens_hsa053230.38994477
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.35148665
128Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.34647149
129Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32830202
130Choline metabolism in cancer_Homo sapiens_hsa052310.32812181

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