NHSL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1limb bud formation (GO:0060174)6.38536479
2desmosome organization (GO:0002934)4.70370769
3paraxial mesoderm development (GO:0048339)4.38552270
4bundle of His cell to Purkinje myocyte communication (GO:0086069)4.28826983
5hemidesmosome assembly (GO:0031581)4.04738854
6presynaptic membrane assembly (GO:0097105)4.02130689
7atrioventricular valve morphogenesis (GO:0003181)3.60836747
8response to pheromone (GO:0019236)3.48770476
9presynaptic membrane organization (GO:0097090)3.47505119
10glial cell proliferation (GO:0014009)3.43777820
11pyrimidine nucleobase catabolic process (GO:0006208)3.40540627
12ventricular cardiac muscle cell action potential (GO:0086005)3.39143953
13regulation of cardioblast differentiation (GO:0051890)3.38994404
14endocardial cushion morphogenesis (GO:0003203)3.26102538
15cell surface receptor signaling pathway involved in heart development (GO:0061311)3.17697356
16neuron projection extension involved in neuron projection guidance (GO:1902284)3.15199162
17axon extension involved in axon guidance (GO:0048846)3.15199162
18renal system development (GO:0072001)3.14399527
19epithelial cell fate commitment (GO:0072148)3.14398966
20C4-dicarboxylate transport (GO:0015740)3.13820998
21neuronal stem cell maintenance (GO:0097150)3.12931076
22mesenchyme morphogenesis (GO:0072132)3.10383359
23collecting duct development (GO:0072044)3.10249125
24nucleobase catabolic process (GO:0046113)3.08799008
25sympathetic nervous system development (GO:0048485)3.06730932
26negative regulation of keratinocyte proliferation (GO:0010839)3.06047767
27negative regulation of transcription regulatory region DNA binding (GO:2000678)3.05640244
28regulation of hippo signaling (GO:0035330)3.05559831
29hippo signaling (GO:0035329)3.05270371
30Notch signaling involved in heart development (GO:0061314)3.02376484
31cerebral cortex radially oriented cell migration (GO:0021799)3.01045612
32negative regulation of astrocyte differentiation (GO:0048712)2.98181015
33lens fiber cell development (GO:0070307)2.97941738
34hindbrain development (GO:0030902)2.97027912
35artery development (GO:0060840)2.96521158
36cell communication involved in cardiac conduction (GO:0086065)2.95949753
37DNA double-strand break processing (GO:0000729)2.93124261
38kidney morphogenesis (GO:0060993)2.93033389
39notochord development (GO:0030903)2.91566027
40planar cell polarity pathway involved in neural tube closure (GO:0090179)2.91469217
41regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.91057292
42replication fork processing (GO:0031297)2.90859702
43regulation of non-canonical Wnt signaling pathway (GO:2000050)2.90045674
44neural tube formation (GO:0001841)2.89699614
45lens morphogenesis in camera-type eye (GO:0002089)2.88933073
46heart valve morphogenesis (GO:0003179)2.86610975
47pattern specification involved in kidney development (GO:0061004)2.86168040
48G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.85926325
49negative regulation of cell fate specification (GO:0009996)2.85367058
50heart valve formation (GO:0003188)2.85289816
51cornea development in camera-type eye (GO:0061303)2.83988655
52negative regulation of chondrocyte differentiation (GO:0032331)2.82205383
53lung epithelium development (GO:0060428)2.81066486
54epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.80778033
55olfactory bulb development (GO:0021772)2.80231436
56embryonic foregut morphogenesis (GO:0048617)2.80059861
57regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.79126865
58regulation of somitogenesis (GO:0014807)2.78055606
59detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.74347858
60male sex determination (GO:0030238)2.73558618
61nonmotile primary cilium assembly (GO:0035058)2.71978259
62morphogenesis of an epithelial sheet (GO:0002011)2.71513230
63cardiac right ventricle morphogenesis (GO:0003215)2.70731426
64otic vesicle formation (GO:0030916)2.69919538
65epithelial cell-cell adhesion (GO:0090136)2.69915195
66platelet dense granule organization (GO:0060155)2.69506493
67spinal cord development (GO:0021510)2.68771815
68negative regulation of catenin import into nucleus (GO:0035414)2.67839317
69L-fucose catabolic process (GO:0042355)2.67132987
70fucose catabolic process (GO:0019317)2.67132987
71L-fucose metabolic process (GO:0042354)2.67132987
72intraciliary transport (GO:0042073)2.65744101
73embryonic camera-type eye development (GO:0031076)2.65323001
74regulation of cell fate specification (GO:0042659)2.64883227
75chondrocyte proliferation (GO:0035988)2.64693750
76ectoderm development (GO:0007398)2.64365834
77regulation of cardioblast proliferation (GO:0003264)2.64237621
78regulation of secondary heart field cardioblast proliferation (GO:0003266)2.64237621
79gastrulation with mouth forming second (GO:0001702)2.63945390
80cardiac muscle cell proliferation (GO:0060038)2.63739015
81positive regulation of glycoprotein biosynthetic process (GO:0010560)2.63655889
82cytoskeletal anchoring at plasma membrane (GO:0007016)2.62191321
83retinal ganglion cell axon guidance (GO:0031290)2.61582875
84cellular response to prostaglandin stimulus (GO:0071379)2.61395935
85epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.60913802
86mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.60585241
87negative regulation of DNA-dependent DNA replication (GO:2000104)2.59866438
88ovulation cycle (GO:0042698)2.59851579
89negative regulation of oligodendrocyte differentiation (GO:0048715)2.59676544
90transepithelial transport (GO:0070633)2.56945752
91prostate gland growth (GO:0060736)2.56735478
92negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.56346619
93negative regulation of translation, ncRNA-mediated (GO:0040033)2.56346619
94regulation of translation, ncRNA-mediated (GO:0045974)2.56346619
95atrial cardiac muscle cell action potential (GO:0086014)2.54802225
96regulation of heart rate by cardiac conduction (GO:0086091)2.54572712
97cell migration in hindbrain (GO:0021535)2.53534016
98regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.52694488
99outer ear morphogenesis (GO:0042473)2.52451933
100photoreceptor cell maintenance (GO:0045494)2.50636999
101aorta morphogenesis (GO:0035909)2.48520475
102embryonic retina morphogenesis in camera-type eye (GO:0060059)2.48121274
103hindlimb morphogenesis (GO:0035137)2.46350970
104establishment of tissue polarity (GO:0007164)2.46334092
105establishment of planar polarity (GO:0001736)2.46334092
106regulation of transforming growth factor beta2 production (GO:0032909)2.46064590
107stress granule assembly (GO:0034063)2.45239519
108regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)2.45192552
109regulation of keratinocyte proliferation (GO:0010837)2.45087535
110water-soluble vitamin biosynthetic process (GO:0042364)2.44289253
111cochlea morphogenesis (GO:0090103)2.43935829
112cilium morphogenesis (GO:0060271)2.43819412
113myoblast fusion (GO:0007520)2.43615260
114thalamus development (GO:0021794)2.42684238
115dorsal/ventral axis specification (GO:0009950)2.42588544
116somatic stem cell division (GO:0048103)2.42065623
117axonal fasciculation (GO:0007413)2.41538912
118regulation of heart morphogenesis (GO:2000826)2.40478954
119cerebral cortex cell migration (GO:0021795)2.40024618
120cellular response to sterol (GO:0036315)2.40016649
121cellular response to cholesterol (GO:0071397)2.38722492
122lung-associated mesenchyme development (GO:0060484)2.38049410
123postsynaptic membrane organization (GO:0001941)2.37794484
124organ formation (GO:0048645)2.37676656
125epithelial cilium movement (GO:0003351)2.37227147
126epithelial cell differentiation involved in prostate gland development (GO:0060742)2.37099077
127coronary vasculature morphogenesis (GO:0060977)2.34804452
128regulation of timing of cell differentiation (GO:0048505)2.34718364
129inner ear receptor stereocilium organization (GO:0060122)2.34531284
130heart morphogenesis (GO:0003007)2.34073711
131central nervous system projection neuron axonogenesis (GO:0021952)2.33570853
132cardiac ventricle morphogenesis (GO:0003208)2.33533579
133establishment of nucleus localization (GO:0040023)2.32882713
134cell junction maintenance (GO:0034331)2.32231820
135embryonic hindlimb morphogenesis (GO:0035116)2.31223608
136retinal cone cell development (GO:0046549)2.29585759
137lateral sprouting from an epithelium (GO:0060601)2.29434058
138auditory receptor cell differentiation (GO:0042491)2.29319453
139regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.29075940
140ventricular trabecula myocardium morphogenesis (GO:0003222)2.28887210
141embryonic digestive tract morphogenesis (GO:0048557)2.28093105
142insulin-like growth factor receptor signaling pathway (GO:0048009)2.27912101
143pancreas development (GO:0031016)2.27773687
144nephron tubule development (GO:0072080)2.27191589
145cilium organization (GO:0044782)2.27028383
146non-canonical Wnt signaling pathway (GO:0035567)2.26100476
147dopaminergic neuron differentiation (GO:0071542)2.25896730
148negative regulation of glial cell proliferation (GO:0060253)2.25872545
149atrial septum morphogenesis (GO:0060413)2.25754777
150head development (GO:0060322)2.25316271
151radial glial cell differentiation (GO:0060019)2.25128200
152regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.24875130
153cilium assembly (GO:0042384)2.23786495
154dendritic spine morphogenesis (GO:0060997)2.23560074
155somite development (GO:0061053)2.23170866
156vitamin A metabolic process (GO:0006776)2.22787518
157negative regulation of dendrite development (GO:2000171)2.22718442
1583-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.22456421
159purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.22456421
160cardiac muscle cell action potential involved in contraction (GO:0086002)2.22411882
161embryonic epithelial tube formation (GO:0001838)2.22199641
162protein prenylation (GO:0018342)2.20529126
163prenylation (GO:0097354)2.20529126
164vitamin biosynthetic process (GO:0009110)2.19870255
165axoneme assembly (GO:0035082)2.19598837
166lung secretory cell differentiation (GO:0061140)2.19116181
167indole-containing compound catabolic process (GO:0042436)2.18317361
168indolalkylamine catabolic process (GO:0046218)2.18317361
169tryptophan catabolic process (GO:0006569)2.18317361
170negative regulation of axon guidance (GO:1902668)2.17977820
171exogenous drug catabolic process (GO:0042738)2.17695428
172drug catabolic process (GO:0042737)2.17234110
173appendage development (GO:0048736)2.15676320
174limb development (GO:0060173)2.15676320
175negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.14681122
176positive regulation of oligodendrocyte differentiation (GO:0048714)2.14612008
177regulation of dendritic spine morphogenesis (GO:0061001)2.13867699
178negative regulation of epidermal cell differentiation (GO:0045605)2.13128923
179respiratory chain complex IV assembly (GO:0008535)2.12633229
180regulation of oligodendrocyte differentiation (GO:0048713)2.12441015
181G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.11237978
182sulfation (GO:0051923)2.11198601
183maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.10910212
184lung lobe morphogenesis (GO:0060463)2.10560745
185photoreceptor cell development (GO:0042461)2.09412342
186forebrain neuron differentiation (GO:0021879)2.09181691

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.43901466
2ZFP57_27257070_Chip-Seq_ESCs_Mouse2.84124439
3ZNF274_21170338_ChIP-Seq_K562_Hela2.75713501
4POU3F2_20337985_ChIP-ChIP_501MEL_Human2.63518433
5FUS_26573619_Chip-Seq_HEK293_Human2.46525643
6VDR_22108803_ChIP-Seq_LS180_Human2.42967622
7* P300_19829295_ChIP-Seq_ESCs_Human2.27495339
8TAF15_26573619_Chip-Seq_HEK293_Human2.27097228
9EZH2_22144423_ChIP-Seq_EOC_Human2.23336990
10IGF1R_20145208_ChIP-Seq_DFB_Human2.16065581
11TRIM28_21343339_ChIP-Seq_HEK293_Human2.16016975
12EWS_26573619_Chip-Seq_HEK293_Human2.10452435
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.09685291
14RNF2_18974828_ChIP-Seq_MESCs_Mouse2.09685291
15CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09170356
16* ZNF217_24962896_ChIP-Seq_MCF-7_Human2.08474975
17EZH2_27304074_Chip-Seq_ESCs_Mouse1.96658918
18GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.94362186
19* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.93817423
20EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.92030299
21CTBP1_25329375_ChIP-Seq_LNCAP_Human1.91137382
22SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.90372642
23RNF2_27304074_Chip-Seq_ESCs_Mouse1.89094059
24SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.88123360
25BCAT_22108803_ChIP-Seq_LS180_Human1.84665497
26EED_16625203_ChIP-ChIP_MESCs_Mouse1.82686578
27JARID2_20075857_ChIP-Seq_MESCs_Mouse1.75365765
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.75203347
29SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.74510171
30SMAD4_21799915_ChIP-Seq_A2780_Human1.73665240
31FLI1_27457419_Chip-Seq_LIVER_Mouse1.72667909
32HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72559092
33* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.71440099
34SMAD3_21741376_ChIP-Seq_EPCs_Human1.70744830
35OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70128448
36CDX2_20551321_ChIP-Seq_CACO-2_Human1.69166117
37* AHR_22903824_ChIP-Seq_MCF-7_Human1.68550734
38SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.68423228
39WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.68229440
40SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.67127717
41ESR2_21235772_ChIP-Seq_MCF-7_Human1.65906055
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.64875199
43SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.64621067
44ISL1_27105846_Chip-Seq_CPCs_Mouse1.63548783
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.62297930
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61876761
47ESR1_21235772_ChIP-Seq_MCF-7_Human1.59558634
48EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.57218129
49ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.56674527
50* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.56530721
51TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.55407260
52NR3C1_21868756_ChIP-Seq_MCF10A_Human1.55337107
53TP63_19390658_ChIP-ChIP_HaCaT_Human1.53530564
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.53137586
55AR_25329375_ChIP-Seq_VCAP_Human1.53016918
56* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52958282
57POU5F1_16153702_ChIP-ChIP_HESCs_Human1.52943013
58* ARNT_22903824_ChIP-Seq_MCF-7_Human1.51353152
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.49144842
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.48543560
61* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.47387966
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.46934295
63STAT3_23295773_ChIP-Seq_U87_Human1.46803227
64* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.46155951
65PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.45687150
66TP53_20018659_ChIP-ChIP_R1E_Mouse1.44411009
67TCF4_22108803_ChIP-Seq_LS180_Human1.44276645
68TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.43633014
69* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.43163912
70ER_23166858_ChIP-Seq_MCF-7_Human1.42799071
71GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.41502306
72PCGF2_27294783_Chip-Seq_NPCs_Mouse1.41093722
73* EZH2_27294783_Chip-Seq_NPCs_Mouse1.40929176
74EP300_21415370_ChIP-Seq_HL-1_Mouse1.40864440
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.40756420
76RING1B_27294783_Chip-Seq_NPCs_Mouse1.40752304
77CBX2_27304074_Chip-Seq_ESCs_Mouse1.40229408
78DROSHA_22980978_ChIP-Seq_HELA_Human1.40012749
79SUZ12_27294783_Chip-Seq_NPCs_Mouse1.39994162
80CBP_20019798_ChIP-Seq_JUKART_Human1.39789829
81IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.39789829
82TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.39743726
83WT1_25993318_ChIP-Seq_PODOCYTE_Human1.39057369
84TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.38682741
85TCF4_23295773_ChIP-Seq_U87_Human1.38380912
86STAT6_21828071_ChIP-Seq_BEAS2B_Human1.38207261
87RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38084888
88* RING1B_27294783_Chip-Seq_ESCs_Mouse1.38082226
89NANOG_18555785_Chip-Seq_ESCs_Mouse1.35642539
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.34381391
91MTF2_20144788_ChIP-Seq_MESCs_Mouse1.33902845
92ZFP281_27345836_Chip-Seq_ESCs_Mouse1.32686607
93SMAD3_21741376_ChIP-Seq_HESCs_Human1.31671616
94SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.28490491
95RUNX2_22187159_ChIP-Seq_PCA_Human1.28347254
96KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.28197750
97EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28008126
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.25722258
99KLF5_20875108_ChIP-Seq_MESCs_Mouse1.25091148
100NFE2_27457419_Chip-Seq_LIVER_Mouse1.24323069
101ESR1_20079471_ChIP-ChIP_T-47D_Human1.24252104
102KDM2B_26808549_Chip-Seq_K562_Human1.23282677
103SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.22763684
104AR_21572438_ChIP-Seq_LNCaP_Human1.22617373
105ZNF263_19887448_ChIP-Seq_K562_Human1.22287150
106FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.21253003
107SMAD4_21741376_ChIP-Seq_HESCs_Human1.20848138
108CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.20513383
109TP53_16413492_ChIP-PET_HCT116_Human1.20512592
110FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20091387
111ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19638929
112TCF4_18268006_ChIP-ChIP_LS174T_Human1.17668762
113TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17513358
114ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.16892721
115CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16795223
116CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16475414
117TP53_18474530_ChIP-ChIP_U2OS_Human1.15640941
118* CDX2_22108803_ChIP-Seq_LS180_Human1.15388235
119MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.15130353
120P53_22387025_ChIP-Seq_ESCs_Mouse1.15054808
121* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.14933616
122PIAS1_25552417_ChIP-Seq_VCAP_Human1.14633016
123* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.13497331
124SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.13479244
125* SOX2_19829295_ChIP-Seq_ESCs_Human1.12118332
126* NANOG_19829295_ChIP-Seq_ESCs_Human1.12118332
127DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10774198
128RUNX1_27514584_Chip-Seq_MCF-7_Human1.10501705
129RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08204518
130SOX2_21211035_ChIP-Seq_LN229_Gbm1.08058616
131NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.07309710
132HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.06852122
133KLF5_25053715_ChIP-Seq_YYC3_Human1.06773648
134PPAR_26484153_Chip-Seq_NCI-H1993_Human1.06575170
135* FLI1_21867929_ChIP-Seq_TH2_Mouse1.06560010
136TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06482416
137TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06060553
138YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05933562
139GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05918200
140EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.05637142
141SMAD4_21741376_ChIP-Seq_EPCs_Human1.05597902
142TAL1_26923725_Chip-Seq_HPCs_Mouse1.04906733
143* CRX_20693478_ChIP-Seq_RETINA_Mouse1.04384556
144* NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.03974587
145E2F1_18555785_Chip-Seq_ESCs_Mouse1.03797178
146BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03338607
147NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.02721929
148GBX2_23144817_ChIP-Seq_PC3_Human1.02149621
149* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02145660
150* TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.02054983
151* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01034220
152* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01034220
153AR_19668381_ChIP-Seq_PC3_Human1.01029900
154LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00288823
155KDM2B_26808549_Chip-Seq_REH_Human1.00240887
156ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.99990810
157CMYC_18555785_Chip-Seq_ESCs_Mouse0.99759137
158* CJUN_26792858_Chip-Seq_BT549_Human0.99700090
159POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99661426
160TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99661426
161SOX9_26525672_Chip-Seq_HEART_Mouse0.99625306
162SUZ12_18555785_Chip-Seq_ESCs_Mouse0.98670537
163* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98361989
164CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.97967867
165CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96537619
166PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.95857836
167TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92844306
168SOX2_27498859_Chip-Seq_STOMACH_Mouse0.91847347
169SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.90324927
170* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.90222934
171* CLOCK_20551151_ChIP-Seq_293T_Human0.89700513
172RNF2_27304074_Chip-Seq_NSC_Mouse0.88812754
173TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88105355
174* SOX2_20726797_ChIP-Seq_SW620_Human0.88076524
175AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.87825246
176FOXO3_23340844_ChIP-Seq_DLD1_Human0.87816932
177TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87637659

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis3.93800784
2MP0010234_abnormal_vibrissa_follicle3.55971659
3MP0010030_abnormal_orbit_morphology3.33057399
4MP0000537_abnormal_urethra_morphology2.61602518
5MP0003941_abnormal_skin_development2.54129015
6MP0005377_hearing/vestibular/ear_phenot2.29134301
7MP0003878_abnormal_ear_physiology2.29134301
8MP0003136_yellow_coat_color2.23382678
9MP0000372_irregular_coat_pigmentation2.21098822
10MP0002249_abnormal_larynx_morphology2.18326022
11MP0005360_urolithiasis2.08037598
12MP0002653_abnormal_ependyma_morphology2.05225134
13MP0003195_calcinosis2.03465514
14MP0005171_absent_coat_pigmentation2.02785468
15MP0003705_abnormal_hypodermis_morpholog2.01374656
16MP0001849_ear_inflammation1.95313441
17MP0000049_abnormal_middle_ear1.91994097
18MP0010678_abnormal_skin_adnexa1.90444708
19MP0004264_abnormal_extraembryonic_tissu1.90193180
20MP0000762_abnormal_tongue_morphology1.87718673
21MP0005248_abnormal_Harderian_gland1.87076720
22MP0009780_abnormal_chondrocyte_physiolo1.84420221
23MP0000778_abnormal_nervous_system1.83794859
24MP0003880_abnormal_central_pattern1.81326348
25MP0005551_abnormal_eye_electrophysiolog1.80002252
26MP0000383_abnormal_hair_follicle1.71300827
27MP0000462_abnormal_digestive_system1.70833370
28MP0002796_impaired_skin_barrier1.68554049
29MP0004272_abnormal_basement_membrane1.67137441
30MP0009384_cardiac_valve_regurgitation1.66438552
31MP0000579_abnormal_nail_morphology1.66408936
32MP0003385_abnormal_body_wall1.63979102
33MP0003755_abnormal_palate_morphology1.62530261
34MP0005253_abnormal_eye_physiology1.61907744
35MP0002638_abnormal_pupillary_reflex1.59584063
36MP0001346_abnormal_lacrimal_gland1.59053249
37MP0005085_abnormal_gallbladder_physiolo1.57622979
38MP0001984_abnormal_olfaction1.57429939
39MP0002234_abnormal_pharynx_morphology1.56311763
40MP0004885_abnormal_endolymph1.56021728
41MP0002282_abnormal_trachea_morphology1.54287318
42MP0006072_abnormal_retinal_apoptosis1.54103075
43MP0002233_abnormal_nose_morphology1.53376833
44MP0005275_abnormal_skin_tensile1.52007851
45MP0000534_abnormal_ureter_morphology1.50433338
46MP0009053_abnormal_anal_canal1.49838068
47MP0006292_abnormal_olfactory_placode1.48379843
48MP0002098_abnormal_vibrissa_morphology1.46921971
49MP0003718_maternal_effect1.44490523
50MP0002736_abnormal_nociception_after1.44136696
51MP0008877_abnormal_DNA_methylation1.42512079
52MP0003122_maternal_imprinting1.41095901
53MP0003935_abnormal_craniofacial_develop1.41010759
54MP0003115_abnormal_respiratory_system1.40968878
55MP0000467_abnormal_esophagus_morphology1.39021951
56MP0003942_abnormal_urinary_system1.38350853
57MP0003119_abnormal_digestive_system1.38076707
58MP0004133_heterotaxia1.36596709
59MP0005187_abnormal_penis_morphology1.36540056
60MP0003937_abnormal_limbs/digits/tail_de1.36328010
61MP0009250_abnormal_appendicular_skeleto1.35790204
62MP0002116_abnormal_craniofacial_bone1.33273268
63MP0000538_abnormal_urinary_bladder1.31490352
64MP0001666_abnormal_nutrient_absorption1.30058252
65MP0002254_reproductive_system_inflammat1.30042722
66MP0004043_abnormal_pH_regulation1.29372881
67MP0001486_abnormal_startle_reflex1.29204625
68MP0001299_abnormal_eye_distance/1.28376860
69MP0004270_analgesia1.26865050
70MP0000647_abnormal_sebaceous_gland1.26273638
71MP0005646_abnormal_pituitary_gland1.25469960
72MP0000428_abnormal_craniofacial_morphol1.23416851
73MP0001529_abnormal_vocalization1.22857366
74MP0003787_abnormal_imprinting1.21802383
75MP0000678_abnormal_parathyroid_gland1.20009904
76MP0002089_abnormal_postnatal_growth/wei1.19203736
77MP0003121_genomic_imprinting1.18915632
78MP0002139_abnormal_hepatobiliary_system1.17261898
79MP0005076_abnormal_cell_differentiation1.16915611
80MP0003938_abnormal_ear_development1.16307079
81MP0003861_abnormal_nervous_system1.15519537
82MP0005408_hypopigmentation1.13751154
83MP0002932_abnormal_joint_morphology1.12825032
84MP0004019_abnormal_vitamin_homeostasis1.12684500
85MP0000432_abnormal_head_morphology1.12127151
86MP0005174_abnormal_tail_pigmentation1.11827601
87MP0002751_abnormal_autonomic_nervous1.11409793
88MP0002876_abnormal_thyroid_physiology1.09798050
89MP0001286_abnormal_eye_development1.09773966
90MP0005365_abnormal_bile_salt1.09327422
91MP0008995_early_reproductive_senescence1.09297358
92MP0001968_abnormal_touch/_nociception1.08834103
93MP0005195_abnormal_posterior_eye1.08043386
94MP0004859_abnormal_synaptic_plasticity1.06930209
95MP0001324_abnormal_eye_pigmentation1.06317224
96MP0002102_abnormal_ear_morphology1.05293861
97MP0004858_abnormal_nervous_system1.04433010
98MP0005501_abnormal_skin_physiology1.04399867
99MP0008789_abnormal_olfactory_epithelium1.03125569
100MP0000026_abnormal_inner_ear1.02431264
101MP0005508_abnormal_skeleton_morphology1.02273999
102MP0002697_abnormal_eye_size1.01608426
103MP0002837_dystrophic_cardiac_calcinosis1.00652947
104MP0002092_abnormal_eye_morphology1.00407767
105MP0003890_abnormal_embryonic-extraembry0.99308667
106MP0000427_abnormal_hair_cycle0.99097061
107MP0002938_white_spotting0.98938940
108MP0000516_abnormal_urinary_system0.97620837
109MP0005367_renal/urinary_system_phenotyp0.97620837
110MP0005391_vision/eye_phenotype0.97574788
111MP0006054_spinal_hemorrhage0.97552987
112MP0008961_abnormal_basal_metabolism0.97457168
113MP0005257_abnormal_intraocular_pressure0.96019568
114MP0010329_abnormal_lipoprotein_level0.95412478
115MP0003315_abnormal_perineum_morphology0.95165316
116MP0003011_delayed_dark_adaptation0.95119322
117MP0002095_abnormal_skin_pigmentation0.94263722
118MP0001485_abnormal_pinna_reflex0.93889487
119MP0002557_abnormal_social/conspecific_i0.92481209
120MP0000613_abnormal_salivary_gland0.92362364
121MP0004134_abnormal_chest_morphology0.92008189
122MP0008875_abnormal_xenobiotic_pharmacok0.90109923
123MP0003567_abnormal_fetal_cardiomyocyte0.89752771
124MP0003868_abnormal_feces_composition0.89745765
125MP0005395_other_phenotype0.88491779
126MP0001293_anophthalmia0.87844024
127MP0002060_abnormal_skin_morphology0.87468125
128MP0002752_abnormal_somatic_nervous0.84761849
129MP0000163_abnormal_cartilage_morphology0.84605670
130MP0000631_abnormal_neuroendocrine_gland0.83576882
131MP0010352_gastrointestinal_tract_polyps0.83346639
132MP0000733_abnormal_muscle_development0.83133985
133MP0001340_abnormal_eyelid_morphology0.83092858
134MP0009697_abnormal_copulation0.83030403
135MP0008058_abnormal_DNA_repair0.83022442
136MP0002084_abnormal_developmental_patter0.82474088
137MP0005499_abnormal_olfactory_system0.82027305
138MP0005394_taste/olfaction_phenotype0.82027305
139MP0006276_abnormal_autonomic_nervous0.81557473
140MP0004215_abnormal_myocardial_fiber0.81418872
141MP0002734_abnormal_mechanical_nocicepti0.80561315
142MP0002177_abnormal_outer_ear0.80503414
143MP0002111_abnormal_tail_morphology0.79470214
144MP0002896_abnormal_bone_mineralization0.79115162
145MP0002085_abnormal_embryonic_tissue0.79098866
146MP0001764_abnormal_homeostasis0.78784676
147MP0005386_behavior/neurological_phenoty0.78692584
148MP0004924_abnormal_behavior0.78692584
149MP0003252_abnormal_bile_duct0.78691331
150MP0000377_abnormal_hair_follicle0.78518421
151MP0003137_abnormal_impulse_conducting0.76992888
152MP0002925_abnormal_cardiovascular_devel0.76443828
153MP0005623_abnormal_meninges_morphology0.76262863
154MP0003283_abnormal_digestive_organ0.75907919
155MP0002184_abnormal_innervation0.75291958
156MP0002272_abnormal_nervous_system0.74736380

Predicted human phenotypes

RankGene SetZ-score
1Right ventricular cardiomyopathy (HP:0011663)4.43616095
2True hermaphroditism (HP:0010459)3.46416240
3Intestinal atresia (HP:0011100)3.38665934
4Onycholysis (HP:0001806)3.15725211
5Pancreatic fibrosis (HP:0100732)3.13773442
6Pancreatic cysts (HP:0001737)3.09523981
7Abnormality of the labia minora (HP:0012880)3.07369878
8Hyperventilation (HP:0002883)3.06637708
9Aplasia involving bones of the upper limbs (HP:0009823)3.03207432
10Aplasia of the phalanges of the hand (HP:0009802)3.03207432
11Aplasia involving bones of the extremities (HP:0009825)3.03207432
12Coronal craniosynostosis (HP:0004440)3.01157089
13Milia (HP:0001056)2.98219669
14Atrophic scars (HP:0001075)2.91277125
15Abnormality of midbrain morphology (HP:0002418)2.78185003
16Molar tooth sign on MRI (HP:0002419)2.78185003
17Volvulus (HP:0002580)2.63501593
18Colon cancer (HP:0003003)2.59416394
19Aplasia cutis congenita (HP:0001057)2.58744521
20Fragile nails (HP:0001808)2.58441092
21Shallow orbits (HP:0000586)2.55407603
22Nephronophthisis (HP:0000090)2.53708968
23Germ cell neoplasia (HP:0100728)2.52098054
24Renal hypoplasia (HP:0000089)2.44673562
25Medial flaring of the eyebrow (HP:0010747)2.43614742
26Renal cortical cysts (HP:0000803)2.43451720
27Bronchomalacia (HP:0002780)2.40715212
28Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.40049984
29Genital tract atresia (HP:0001827)2.39288780
30Shawl scrotum (HP:0000049)2.39044173
31Woolly hair (HP:0002224)2.36134518
32Abnormality of the renal cortex (HP:0011035)2.35680814
33Epidermoid cyst (HP:0200040)2.32407185
34Vaginal atresia (HP:0000148)2.29468252
35Lip pit (HP:0100267)2.29099978
36Abnormality of the renal medulla (HP:0100957)2.28909992
37Short 4th metacarpal (HP:0010044)2.28787271
38Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.28787271
39High anterior hairline (HP:0009890)2.28362202
40Gastrointestinal atresia (HP:0002589)2.28161827
41Hyperglycinemia (HP:0002154)2.26337177
42Down-sloping shoulders (HP:0200021)2.25518992
43Morphological abnormality of the middle ear (HP:0008609)2.24251418
44Congenital sensorineural hearing impairment (HP:0008527)2.23311329
45Vitreoretinal degeneration (HP:0000655)2.22250804
46Curly hair (HP:0002212)2.21099605
47Hyperglycinuria (HP:0003108)2.18640310
48Neonatal short-limb short stature (HP:0008921)2.17642515
49Cystic liver disease (HP:0006706)2.17229383
50Hypoplastic labia majora (HP:0000059)2.16256654
51Abnormality of serine family amino acid metabolism (HP:0010894)2.15817605
52Abnormality of glycine metabolism (HP:0010895)2.15817605
53Trigonocephaly (HP:0000243)2.14894426
54Bilateral microphthalmos (HP:0007633)2.14375076
55Aplasia/Hypoplasia of the tongue (HP:0010295)2.14111778
56Alacrima (HP:0000522)2.13310813
57Bifid tongue (HP:0010297)2.11563534
58Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.10082113
59Mixed hearing impairment (HP:0000410)2.08688696
60Increased corneal curvature (HP:0100692)2.08647310
61Keratoconus (HP:0000563)2.08647310
62Exotropia (HP:0000577)2.07786832
63Postaxial hand polydactyly (HP:0001162)2.07446342
64Preaxial hand polydactyly (HP:0001177)2.06583315
65Midline defect of the nose (HP:0004122)2.04539797
66Uterine leiomyosarcoma (HP:0002891)2.04395375
67Leiomyosarcoma (HP:0100243)2.04395375
68Cupped ear (HP:0000378)2.03822610
69Abnormality of the 4th metacarpal (HP:0010012)2.03042449
70Oligodactyly (HP:0012165)2.02805604
71Anterior segment dysgenesis (HP:0007700)2.02025009
72Oligodactyly (hands) (HP:0001180)2.00927129
73Ventricular tachycardia (HP:0004756)2.00398992
74Preaxial foot polydactyly (HP:0001841)2.00153894
75Pendular nystagmus (HP:0012043)1.99457352
76Abnormality of the labia majora (HP:0012881)1.98641794
77Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.98163175
78Short 1st metacarpal (HP:0010034)1.98163175
79Long clavicles (HP:0000890)1.96792358
80Chorioretinal atrophy (HP:0000533)1.95890425
81Hypobetalipoproteinemia (HP:0003563)1.95644369
82Congenital primary aphakia (HP:0007707)1.95415686
83Gait imbalance (HP:0002141)1.94742576
84Elfin facies (HP:0004428)1.94230359
85Aplasia/Hypoplasia of the tibia (HP:0005772)1.93825022
86Broad-based gait (HP:0002136)1.93468188
87Malignant gastrointestinal tract tumors (HP:0006749)1.91424668
88Gastrointestinal carcinoma (HP:0002672)1.91424668
89Postaxial foot polydactyly (HP:0001830)1.90317718
90Hepatoblastoma (HP:0002884)1.90038645
91Pili torti (HP:0003777)1.89846630
92Humeroradial synostosis (HP:0003041)1.89796294
93Synostosis involving the elbow (HP:0003938)1.89796294
94Renal duplication (HP:0000075)1.89269409
95Astrocytoma (HP:0009592)1.88567344
96Abnormality of the astrocytes (HP:0100707)1.88567344
97Sclerocornea (HP:0000647)1.87946910
98Hypothermia (HP:0002045)1.87813578
99Skull defect (HP:0001362)1.87545223
100Hypoplasia of the fovea (HP:0007750)1.86498821
101Aplasia/Hypoplasia of the fovea (HP:0008060)1.86498821
102Neoplasm of the adrenal cortex (HP:0100641)1.85463213
103Advanced eruption of teeth (HP:0006288)1.85045931
104Megalencephaly (HP:0001355)1.84696282
105Abnormality of the 1st metacarpal (HP:0010009)1.84639632
106Esophageal atresia (HP:0002032)1.82946245
107Abnormality of the lower motor neuron (HP:0002366)1.82373652
108Rectal prolapse (HP:0002035)1.82310707
109Cutaneous finger syndactyly (HP:0010554)1.81680594
110Abnormality of vitamin B metabolism (HP:0004340)1.81216467
111Short hallux (HP:0010109)1.80892568
112Congenital stationary night blindness (HP:0007642)1.80890576
113Abnormal lung lobation (HP:0002101)1.80859562
114Tented upper lip vermilion (HP:0010804)1.80835432
115Abnormality of the phalanges of the 2nd finger (HP:0009541)1.80558986
116Abnormality of the gastric mucosa (HP:0004295)1.80418172
117Chronic hepatic failure (HP:0100626)1.80395944
118Aqueductal stenosis (HP:0002410)1.80391174
119Transitional cell carcinoma of the bladder (HP:0006740)1.80272853
120Aplasia/Hypoplasia of the hallux (HP:0008362)1.79817452
121Pterygium (HP:0001059)1.79243211
122Abnormality of the nasal septum (HP:0000419)1.79139891
123Anencephaly (HP:0002323)1.79040658
124Abnormality of the middle phalanges of the toes (HP:0010183)1.78988677
125Optic nerve hypoplasia (HP:0000609)1.78951108
126Absent eyebrow (HP:0002223)1.78904034
127Subacute progressive viral hepatitis (HP:0006572)1.78726470
128Drooling (HP:0002307)1.77309140
129Occipital encephalocele (HP:0002085)1.76403824
130Abnormality of the ileum (HP:0001549)1.76339418
131Hemiparesis (HP:0001269)1.75704324
132Scrotal hypoplasia (HP:0000046)1.75670246
133Tarsal synostosis (HP:0008368)1.75349803
134Hypoplasia of dental enamel (HP:0006297)1.75134017
135Broad metatarsal (HP:0001783)1.74841190
136Hyperacusis (HP:0010780)1.74649942
137Decreased lacrimation (HP:0000633)1.74526314
138Stenosis of the external auditory canal (HP:0000402)1.73426612
139Renovascular hypertension (HP:0100817)1.73249592
140Labial hypoplasia (HP:0000066)1.71706637
141Nephrogenic diabetes insipidus (HP:0009806)1.71614287
142Papillary thyroid carcinoma (HP:0002895)1.71515827
143Abnormality of the lacrimal duct (HP:0011481)1.70910884
144Fragile skin (HP:0001030)1.70876867
145Synostosis of carpal bones (HP:0005048)1.70527679
146Periauricular skin pits (HP:0100277)1.70477548
147Preauricular pit (HP:0004467)1.70477548
148Urethral obstruction (HP:0000796)1.70402319
149Aplasia/Hypoplasia of the uvula (HP:0010293)1.70181062
150Sudden death (HP:0001699)1.69790833
151Meckel diverticulum (HP:0002245)1.69748886
152Male pseudohermaphroditism (HP:0000037)1.68728846
153Glioma (HP:0009733)1.68647500
154Short tibia (HP:0005736)1.68382522
155Congenital hepatic fibrosis (HP:0002612)1.68167272
156Deviation of the hallux (HP:0010051)1.67907388
157Hypoplastic toenails (HP:0001800)1.67486846
158Narrow forehead (HP:0000341)1.67093334
159Abnormality of the antihelix (HP:0009738)1.66422290
160Abnormality of aspartate family amino acid metabolism (HP:0010899)1.66393787
161Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.66353679
162Broad toe (HP:0001837)1.66117367
163Mildly elevated creatine phosphokinase (HP:0008180)1.65761994
164Cutaneous syndactyly (HP:0012725)1.65089441
165Broad hallux (HP:0010055)1.64958379
166Synostosis involving bones of the feet (HP:0009140)1.64892585
167Synostosis involving bones of the lower limbs (HP:0009138)1.64892585
168Abnormality of the pubic bones (HP:0003172)1.64745489
169Macroorchidism (HP:0000053)1.64413392
170Abolished electroretinogram (ERG) (HP:0000550)1.63956469
171Abnormality of the vitamin B12 metabolism (HP:0004341)1.63925867
172Abnormality of the proximal phalanges of the hand (HP:0009834)1.63614534
173Dandy-Walker malformation (HP:0001305)1.62091458
174Skin pits (HP:0100276)1.61161359
175Plantar hyperkeratosis (HP:0007556)1.60803626
176Long nose (HP:0003189)1.60677463
177Hypoplastic ischia (HP:0003175)1.60638275
178Abnormality of the ischium (HP:0003174)1.60612722
179Astigmatism (HP:0000483)1.60478141
180Nasolacrimal duct obstruction (HP:0000579)1.60296829
181Hypoplastic nipples (HP:0002557)1.60119768
182Decreased central vision (HP:0007663)1.59366677
183Bladder carcinoma (HP:0002862)1.58649015
184Bladder neoplasm (HP:0009725)1.58649015
185Abnormality of the nasolacrimal system (HP:0000614)1.55843778
186Aplasia/Hypoplasia of the sternum (HP:0006714)1.55284606
187Progressive sensorineural hearing impairment (HP:0000408)1.55010313
188Increased nuchal translucency (HP:0010880)1.54845566
189Anophthalmia (HP:0000528)1.54430238
190Abnormality of the intervertebral disk (HP:0005108)1.54085618
191Abnormality of the right ventricle (HP:0001707)1.51991031

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.11304476
2TAOK23.92447126
3EPHB23.76900673
4TNIK3.69620016
5CDK123.32350018
6MAP4K22.92842589
7CASK2.86333635
8SIK32.83793407
9WNK32.78196454
10PRPF4B2.77127172
11DDR22.50424358
12FER2.39612225
13EPHA22.38201280
14EPHA42.13908522
15MAPKAPK32.09658086
16MKNK22.06537834
17TRIM282.06267283
18STK392.05326128
19SIK12.05182883
20BMPR1B2.02797666
21BCR1.97563396
22KSR11.97047867
23PNCK1.95697376
24LMTK21.93737645
25MAP3K41.93275649
26PLK21.88875534
27ACVR1B1.88500724
28LATS21.87664413
29DMPK1.86664540
30GRK11.82383057
31PINK11.81528987
32TYRO31.78561587
33STK38L1.71443125
34PDGFRA1.71375417
35WEE11.65351594
36UHMK11.63057495
37ICK1.55976210
38PLK41.54571276
39PTK61.54482373
40CSNK1G11.49179947
41MKNK11.43643092
42FGFR11.36538849
43BRSK21.33821374
44PLK31.32326319
45RIPK11.31734011
46MAP3K91.25997238
47CSNK1G21.20694498
48ERBB21.20130299
49ERBB31.20024579
50OXSR11.15489855
51ERN11.15191214
52MARK11.14790755
53CSNK1G31.13075023
54WNK41.12823920
55CCNB11.12228589
56NLK1.12181350
57EIF2AK31.10997807
58MAP2K71.10721634
59PTK21.10710698
60NEK11.08086930
61EEF2K1.07725545
62FGFR31.05838688
63PAK31.05749702
64ADRBK21.01867370
65MST40.99920404
66ROCK10.99183007
67PRKCE0.98636106
68TAF10.97158648
69EPHA30.96660260
70PAK40.95982138
71DYRK1B0.93644710
72FRK0.93617695
73PRKD30.89211816
74VRK10.87939105
75MTOR0.87444736
76ZAK0.84761383
77MAPK150.84486771
78PDGFRB0.84393225
79NTRK20.82302206
80MINK10.81809021
81TRIB30.78752085
82STK240.77830092
83PRKCG0.77414859
84BRD40.76987795
85CDC42BPA0.76812124
86ERBB40.76550832
87STK380.73977448
88STK30.72504027
89FGFR20.70529971
90VRK20.70421222
91TGFBR10.68158405
92TIE10.66957163
93CDK60.64219702
94CAMK1G0.63216378
95PLK10.62477603
96EIF2AK10.61498356
97PIK3CA0.61413535
98PKN10.61052641
99TTN0.60757147
100BUB10.58186964
101MAP3K70.57836485
102BMX0.57815924
103NUAK10.57386440
104NTRK30.54003370
105MUSK0.53810502
106MAP3K20.53423428
107RPS6KB20.53022937
108TGFBR20.51338926
109MELK0.50354427
110SRPK10.49716411
111WNK10.49269399
112CAMK1D0.48260932
113CSNK1A10.47413618
114MET0.47166710
115YES10.46873627
116SGK20.45473270
117ATM0.45174188
118ROCK20.45173819
119MAP3K50.44317043
120PAK60.43637446
121MAP2K60.43568341
122BRSK10.42806503
123CDK80.40972561
124CSNK1D0.40574030
125AKT20.40062033
126MAPK130.39063106
127PHKG10.38767894
128PHKG20.38767894
129CAMK2A0.38550665
130SGK30.36957529
131SGK2230.36475865
132SGK4940.36475865
133NME10.36129172
134TTK0.35918519
135RET0.35845507
136PRKCZ0.35691892
137MATK0.35669145
138MAP2K20.35325944
139ADRBK10.34376827
140PRKAA10.34051980
141ATR0.33838227
142CSNK1A1L0.33349527
143MARK20.33260011
144AKT30.32860014
145MAPK90.32503058
146PRKACA0.32215616
147MAP3K100.31568114
148CDK180.31334070
149PRKG10.31311278
150TESK10.30876477
151MAPKAPK50.30747098
152CAMK2D0.30642521
153INSRR0.30492223
154CSNK1E0.30143027
155PAK20.29975226
156EIF2AK20.29832104
157GSK3A0.29777498
158MST1R0.29744568
159DYRK20.29281014
160PKN20.29204043
161MAPK80.28982311
162PRKDC0.28938979
163CDK90.27998118
164PRKD10.27615663
165MAP2K10.26845996
166PRKCI0.26779328
167CDK30.25856676

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.10525601
2Basal cell carcinoma_Homo sapiens_hsa052173.04871270
3Adherens junction_Homo sapiens_hsa045202.58583194
4Hippo signaling pathway_Homo sapiens_hsa043902.50960366
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.45259267
6Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.40784886
7Steroid biosynthesis_Homo sapiens_hsa001002.37059213
8Hedgehog signaling pathway_Homo sapiens_hsa043402.20921791
9Propanoate metabolism_Homo sapiens_hsa006402.19031833
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.18129364
11Butanoate metabolism_Homo sapiens_hsa006502.13827220
12Notch signaling pathway_Homo sapiens_hsa043302.13213772
13Caffeine metabolism_Homo sapiens_hsa002322.09725492
14Axon guidance_Homo sapiens_hsa043601.98096257
15Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.97732063
16Tight junction_Homo sapiens_hsa045301.93058797
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.91267131
18Dorso-ventral axis formation_Homo sapiens_hsa043201.85822440
19Endometrial cancer_Homo sapiens_hsa052131.84918606
20Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.81815959
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.81151553
22Protein export_Homo sapiens_hsa030601.80805808
23Non-homologous end-joining_Homo sapiens_hsa034501.78296342
24Retinol metabolism_Homo sapiens_hsa008301.74731982
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.73845385
26Linoleic acid metabolism_Homo sapiens_hsa005911.73215615
27Wnt signaling pathway_Homo sapiens_hsa043101.72834027
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70938306
29Protein digestion and absorption_Homo sapiens_hsa049741.68649167
30Chemical carcinogenesis_Homo sapiens_hsa052041.68131704
31alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56762159
32Tryptophan metabolism_Homo sapiens_hsa003801.55313200
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.54603099
34Proteoglycans in cancer_Homo sapiens_hsa052051.54295450
35ECM-receptor interaction_Homo sapiens_hsa045121.54106402
36MicroRNAs in cancer_Homo sapiens_hsa052061.53090363
37Focal adhesion_Homo sapiens_hsa045101.49666383
38Phototransduction_Homo sapiens_hsa047441.49143976
39Melanogenesis_Homo sapiens_hsa049161.48888320
40Steroid hormone biosynthesis_Homo sapiens_hsa001401.46206493
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.45715859
42Dilated cardiomyopathy_Homo sapiens_hsa054141.44721653
43Fatty acid degradation_Homo sapiens_hsa000711.44297180
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.44192148
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.42728455
46TGF-beta signaling pathway_Homo sapiens_hsa043501.42676440
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.39701067
48Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.39484095
49Histidine metabolism_Homo sapiens_hsa003401.37469567
50Bladder cancer_Homo sapiens_hsa052191.36150789
51Fanconi anemia pathway_Homo sapiens_hsa034601.34055107
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32901042
53Thyroid hormone signaling pathway_Homo sapiens_hsa049191.30886590
54Mineral absorption_Homo sapiens_hsa049781.29585825
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29105294
56Ether lipid metabolism_Homo sapiens_hsa005651.24143936
57Cyanoamino acid metabolism_Homo sapiens_hsa004601.20041940
58Fat digestion and absorption_Homo sapiens_hsa049751.18492856
59ErbB signaling pathway_Homo sapiens_hsa040121.15713648
60Fatty acid metabolism_Homo sapiens_hsa012121.13233059
61GnRH signaling pathway_Homo sapiens_hsa049121.12527926
62Homologous recombination_Homo sapiens_hsa034401.12129667
63Peroxisome_Homo sapiens_hsa041461.11914767
64Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.11865455
65Basal transcription factors_Homo sapiens_hsa030221.10905148
66Lysine degradation_Homo sapiens_hsa003101.10034940
67Gap junction_Homo sapiens_hsa045401.08774968
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08513368
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08136922
70Small cell lung cancer_Homo sapiens_hsa052221.07655232
71Colorectal cancer_Homo sapiens_hsa052101.05746323
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.02417551
73Rap1 signaling pathway_Homo sapiens_hsa040151.02268623
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.01789474
75Gastric acid secretion_Homo sapiens_hsa049711.01682150
76Nicotine addiction_Homo sapiens_hsa050331.01327319
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00293936
78Sulfur metabolism_Homo sapiens_hsa009201.00160474
79Pathways in cancer_Homo sapiens_hsa052000.99869330
80Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.98222644
81Starch and sucrose metabolism_Homo sapiens_hsa005000.96187891
82Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.95569885
83Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.94589776
84Vitamin B6 metabolism_Homo sapiens_hsa007500.91947751
85Nitrogen metabolism_Homo sapiens_hsa009100.91140432
86Renin-angiotensin system_Homo sapiens_hsa046140.90695585
87Drug metabolism - other enzymes_Homo sapiens_hsa009830.90307217
88beta-Alanine metabolism_Homo sapiens_hsa004100.88225491
89Selenocompound metabolism_Homo sapiens_hsa004500.87970979
90PPAR signaling pathway_Homo sapiens_hsa033200.87719995
91Bile secretion_Homo sapiens_hsa049760.87184272
92Regulation of actin cytoskeleton_Homo sapiens_hsa048100.86932082
93ABC transporters_Homo sapiens_hsa020100.86922424
94Fatty acid biosynthesis_Homo sapiens_hsa000610.85478564
95Glioma_Homo sapiens_hsa052140.85182995
96Complement and coagulation cascades_Homo sapiens_hsa046100.84465404
97Insulin secretion_Homo sapiens_hsa049110.84310987
98Choline metabolism in cancer_Homo sapiens_hsa052310.83766420
99Glycerolipid metabolism_Homo sapiens_hsa005610.83728278
100Melanoma_Homo sapiens_hsa052180.82523015
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.82020824
102Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.81934969
103Amoebiasis_Homo sapiens_hsa051460.80744593
104Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.80352897
105Taste transduction_Homo sapiens_hsa047420.80342188
106RNA degradation_Homo sapiens_hsa030180.80108912
107Estrogen signaling pathway_Homo sapiens_hsa049150.79867518
108Cysteine and methionine metabolism_Homo sapiens_hsa002700.79073062
109Chronic myeloid leukemia_Homo sapiens_hsa052200.79058902
110Arginine and proline metabolism_Homo sapiens_hsa003300.79029710
111Prostate cancer_Homo sapiens_hsa052150.78723449
112Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.77644878
113Circadian entrainment_Homo sapiens_hsa047130.75644793
114Glutamatergic synapse_Homo sapiens_hsa047240.74691248
115Pyruvate metabolism_Homo sapiens_hsa006200.72650633
116Maturity onset diabetes of the young_Homo sapiens_hsa049500.72230762
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.71840716
118Renal cell carcinoma_Homo sapiens_hsa052110.71672539
119mRNA surveillance pathway_Homo sapiens_hsa030150.71241837
120Oxytocin signaling pathway_Homo sapiens_hsa049210.71089778
121Tyrosine metabolism_Homo sapiens_hsa003500.70217556
122Long-term depression_Homo sapiens_hsa047300.69833862
123Salivary secretion_Homo sapiens_hsa049700.68746318
124Thyroid cancer_Homo sapiens_hsa052160.68344594
125Leukocyte transendothelial migration_Homo sapiens_hsa046700.67747311
126PI3K-Akt signaling pathway_Homo sapiens_hsa041510.67723770
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67413523
128Fatty acid elongation_Homo sapiens_hsa000620.67129649
129Pancreatic cancer_Homo sapiens_hsa052120.65907330
130Circadian rhythm_Homo sapiens_hsa047100.65789033
131Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65644740
132cAMP signaling pathway_Homo sapiens_hsa040240.64837365
133Oocyte meiosis_Homo sapiens_hsa041140.64762197
134Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.64748356
135Arachidonic acid metabolism_Homo sapiens_hsa005900.64294923
136Viral myocarditis_Homo sapiens_hsa054160.64001534
137cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63781362
138VEGF signaling pathway_Homo sapiens_hsa043700.63742406
139Sphingolipid metabolism_Homo sapiens_hsa006000.63576125
140Pancreatic secretion_Homo sapiens_hsa049720.63103414
141Dopaminergic synapse_Homo sapiens_hsa047280.62473046
142Ras signaling pathway_Homo sapiens_hsa040140.61750205
143Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.60394974
144Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.60337668
145Vitamin digestion and absorption_Homo sapiens_hsa049770.59990660
146Insulin resistance_Homo sapiens_hsa049310.59811018
147Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.59788003
148Amphetamine addiction_Homo sapiens_hsa050310.59587330
149Glutathione metabolism_Homo sapiens_hsa004800.59568226
150Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.59405912
151Arginine biosynthesis_Homo sapiens_hsa002200.59256251
152Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.59168956
153Long-term potentiation_Homo sapiens_hsa047200.58652187
154Renin secretion_Homo sapiens_hsa049240.57279691
155AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57180789
156Thyroid hormone synthesis_Homo sapiens_hsa049180.57002476
157RNA polymerase_Homo sapiens_hsa030200.55725145
158Metabolic pathways_Homo sapiens_hsa011000.55457945
159Ovarian steroidogenesis_Homo sapiens_hsa049130.54731990
160Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.54493702
161Insulin signaling pathway_Homo sapiens_hsa049100.54334940
162MAPK signaling pathway_Homo sapiens_hsa040100.53986302
163AMPK signaling pathway_Homo sapiens_hsa041520.53818368
164Serotonergic synapse_Homo sapiens_hsa047260.53208945
165FoxO signaling pathway_Homo sapiens_hsa040680.52988395
166Prolactin signaling pathway_Homo sapiens_hsa049170.52001164
167Cholinergic synapse_Homo sapiens_hsa047250.51946209
168Aldosterone synthesis and secretion_Homo sapiens_hsa049250.51860871
169Oxidative phosphorylation_Homo sapiens_hsa001900.46007965
170Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.43687784
171Folate biosynthesis_Homo sapiens_hsa007900.43153036
1722-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42707570
173GABAergic synapse_Homo sapiens_hsa047270.41396978
174Mismatch repair_Homo sapiens_hsa034300.39710775

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