NHSL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.43237613
2negative regulation of cell killing (GO:0031342)6.43237613
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.30617543
4positive regulation by symbiont of host defense response (GO:0052509)6.24309126
5modulation by symbiont of host defense response (GO:0052031)6.24309126
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.24309126
7modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.24309126
8positive regulation by organism of defense response of other organism involved in symbiotic interact6.24309126
9modulation by symbiont of host immune response (GO:0052553)6.24309126
10positive regulation of gamma-delta T cell activation (GO:0046645)5.97062017
11locomotory exploration behavior (GO:0035641)5.64833517
12detection of molecule of bacterial origin (GO:0032490)5.42869648
13regulation of B cell receptor signaling pathway (GO:0050855)5.40166839
14positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.11273267
15macrophage activation involved in immune response (GO:0002281)5.05489799
16regulation of short-term neuronal synaptic plasticity (GO:0048172)4.94539679
17microglial cell activation (GO:0001774)4.91016196
18synaptic vesicle maturation (GO:0016188)4.87448335
19vocalization behavior (GO:0071625)4.83730241
20detection of other organism (GO:0098543)4.80359984
21neutrophil activation involved in immune response (GO:0002283)4.78989027
22cellular extravasation (GO:0045123)4.78063349
23antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.73852423
24regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.67055066
25antigen processing and presentation of endogenous antigen (GO:0019883)4.62241012
26detection of external biotic stimulus (GO:0098581)4.61932527
27ionotropic glutamate receptor signaling pathway (GO:0035235)4.58602778
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.56654104
29positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.55669341
30regulation of glutamate receptor signaling pathway (GO:1900449)4.48047285
31regulation of gamma-delta T cell activation (GO:0046643)4.47019313
32response to interleukin-15 (GO:0070672)4.41745039
33response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.36667250
34response to host immune response (GO:0052572)4.36667250
35positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.35158751
36negative regulation of lymphocyte mediated immunity (GO:0002707)4.32383627
37synaptic vesicle exocytosis (GO:0016079)4.32168080
38neutrophil activation (GO:0042119)4.29877297
39regulation of interferon-beta biosynthetic process (GO:0045357)4.27786896
40detection of bacterium (GO:0016045)4.25481449
41macrophage activation (GO:0042116)4.24160416
42neutrophil mediated immunity (GO:0002446)4.23855025
43cellular response to interleukin-15 (GO:0071350)4.20743125
44regulation of gamma-delta T cell differentiation (GO:0045586)4.15379725
45negative regulation of interleukin-12 production (GO:0032695)4.15012337
46exploration behavior (GO:0035640)4.13699910
47regulation of synapse structural plasticity (GO:0051823)4.12706753
48antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.10952149
49response to peptidoglycan (GO:0032494)4.07966708
50detection of biotic stimulus (GO:0009595)4.06824856
51leukocyte aggregation (GO:0070486)4.05925409
52regulation of long-term neuronal synaptic plasticity (GO:0048169)4.03561727
53synaptic vesicle docking involved in exocytosis (GO:0016081)4.03022806
54response to host defenses (GO:0052200)3.99487748
55response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.99487748
56response to host (GO:0075136)3.99487748
57dendritic spine morphogenesis (GO:0060997)3.97272315
58regulation of synaptic vesicle exocytosis (GO:2000300)3.95146973
59glutamate receptor signaling pathway (GO:0007215)3.94840137
60positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.94092629
61membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.88393362
62regulation of neuronal synaptic plasticity (GO:0048168)3.81444301
63negative regulation of T cell mediated immunity (GO:0002710)3.81060057
64glutamate secretion (GO:0014047)3.80049134
65synaptic transmission, glutamatergic (GO:0035249)3.78736106
66regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.76922537
67negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.75448014
68myeloid cell activation involved in immune response (GO:0002275)3.73037315
69respiratory burst (GO:0045730)3.72366453
70granulocyte activation (GO:0036230)3.72018437
71negative regulation of leukocyte mediated immunity (GO:0002704)3.69969967
72long-term memory (GO:0007616)3.64782891
73protein localization to synapse (GO:0035418)3.64422993
74activated T cell proliferation (GO:0050798)3.61956375
75myeloid leukocyte mediated immunity (GO:0002444)3.61341363
76regulation of synaptic vesicle transport (GO:1902803)3.53105612
77auditory behavior (GO:0031223)3.52000545
78neuron-neuron synaptic transmission (GO:0007270)3.51048998
79positive regulation of mast cell activation (GO:0033005)3.50090843
80establishment of nucleus localization (GO:0040023)3.49723653
81neuronal action potential propagation (GO:0019227)3.48162436
82regulation of excitatory postsynaptic membrane potential (GO:0060079)3.45966980
83B cell receptor signaling pathway (GO:0050853)3.44837797
84neurotransmitter secretion (GO:0007269)3.44120959
85neurotransmitter-gated ion channel clustering (GO:0072578)3.43583963
86cerebellar Purkinje cell differentiation (GO:0021702)3.36990531
87positive regulation of membrane potential (GO:0045838)3.35922614
88regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.35583511
89regulation of B cell differentiation (GO:0045577)3.34074077
90regulation of dendritic spine morphogenesis (GO:0061001)3.32873082
91neuron cell-cell adhesion (GO:0007158)3.30947418
92positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.29016712
93regulation of mast cell degranulation (GO:0043304)3.28676750
94antigen processing and presentation via MHC class Ib (GO:0002475)3.28672147
95cellular potassium ion homeostasis (GO:0030007)3.28240150
96G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.27842763
97production of molecular mediator involved in inflammatory response (GO:0002532)3.27247732
98layer formation in cerebral cortex (GO:0021819)3.25760600
99regulation of postsynaptic membrane potential (GO:0060078)3.24873159
100regulation of mast cell activation (GO:0033003)3.24648067
101dendritic cell migration (GO:0036336)3.24472171
102mechanosensory behavior (GO:0007638)3.19957201
103regulation of synaptic plasticity (GO:0048167)3.18979853
104neuromuscular process controlling balance (GO:0050885)3.18383449
105regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.17586044
106negative regulation of T-helper cell differentiation (GO:0045623)3.17475784
107negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.17475784
108negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.16391646
109negative T cell selection (GO:0043383)3.15614068
110leukocyte migration involved in inflammatory response (GO:0002523)3.14303956
111negative thymic T cell selection (GO:0045060)3.14263577
112regulation of mast cell activation involved in immune response (GO:0033006)3.13280801
113response to auditory stimulus (GO:0010996)3.12092482
114proline transport (GO:0015824)3.11849958
115regulation of T cell mediated cytotoxicity (GO:0001914)3.11353274
116leukocyte degranulation (GO:0043299)3.10576583
117gamma-aminobutyric acid signaling pathway (GO:0007214)3.10347394
118regulation of tolerance induction (GO:0002643)3.10035292
119immunoglobulin mediated immune response (GO:0016064)3.09785343
120activation of protein kinase A activity (GO:0034199)3.05983663
121positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.04674079
122positive regulation of B cell differentiation (GO:0045579)3.03685798
123regulation of myeloid leukocyte mediated immunity (GO:0002886)3.03608108
124positive regulation of T cell mediated cytotoxicity (GO:0001916)3.03498668
125transmission of nerve impulse (GO:0019226)3.00174653
126regulation of synaptic transmission, glutamatergic (GO:0051966)2.99833184
127positive thymic T cell selection (GO:0045059)2.99431502
128cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.97910860
129regulation of T cell tolerance induction (GO:0002664)2.97616347
130positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.97413314
131long-term synaptic potentiation (GO:0060291)2.97055545
132dendritic cell chemotaxis (GO:0002407)2.96846243
133G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.95602364
134behavioral fear response (GO:0001662)2.92868469
135behavioral defense response (GO:0002209)2.92868469
136gamma-aminobutyric acid transport (GO:0015812)2.92714181
137membrane depolarization during action potential (GO:0086010)2.92603664
138regulation of regulatory T cell differentiation (GO:0045589)2.92240828
139positive T cell selection (GO:0043368)2.92058205
140dendritic spine organization (GO:0097061)2.91744827
141negative regulation of synaptic transmission, GABAergic (GO:0032229)2.90941928
142positive regulation of synapse maturation (GO:0090129)2.90899892
143regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.90430153
144regulation of alpha-beta T cell proliferation (GO:0046640)2.89976161
145myeloid leukocyte activation (GO:0002274)2.89632228
146regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.89405020
147sodium ion export (GO:0071436)2.88599787
148positive regulation of mast cell degranulation (GO:0043306)2.87948488
149positive regulation of mast cell activation involved in immune response (GO:0033008)2.87948488
150negative regulation of adaptive immune response (GO:0002820)2.87832868
151negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.87157616
152positive regulation of dendritic spine development (GO:0060999)2.86236082
153defense response to protozoan (GO:0042832)2.86091127
154neuron recognition (GO:0008038)2.85352361
155membrane depolarization (GO:0051899)2.85101399
156negative regulation of cytosolic calcium ion concentration (GO:0051481)2.84951915
157positive regulation of tolerance induction (GO:0002645)2.84397667
158regulation of leukocyte degranulation (GO:0043300)2.84182477
159axonal fasciculation (GO:0007413)2.83850609
160L-amino acid import (GO:0043092)2.83147420
161prepulse inhibition (GO:0060134)2.83132455
162positive regulation of dendritic spine morphogenesis (GO:0061003)2.83007262
163response to muramyl dipeptide (GO:0032495)2.82917491
164glycine transport (GO:0015816)2.82623962
165response to type I interferon (GO:0034340)2.81244590
166type I interferon signaling pathway (GO:0060337)2.81077861
167cellular response to type I interferon (GO:0071357)2.81077861
168negative regulation of interleukin-6 production (GO:0032715)2.80818002
169response to histamine (GO:0034776)2.80597795
170synaptic vesicle endocytosis (GO:0048488)2.80567374
171cell communication by electrical coupling (GO:0010644)2.79540692
172regulation of dendritic spine development (GO:0060998)2.79066991
173positive regulation of granulocyte differentiation (GO:0030854)2.79045820
174neutrophil chemotaxis (GO:0030593)2.78836951
175serotonin metabolic process (GO:0042428)2.78666962
176regulation of vesicle fusion (GO:0031338)2.78566244
177mast cell activation (GO:0045576)2.77190020
178negative regulation of B cell mediated immunity (GO:0002713)2.76508739
179positive regulation of synaptic transmission, GABAergic (GO:0032230)2.76143749
180neurotransmitter transport (GO:0006836)2.73323943
181learning (GO:0007612)2.71325732
182dendrite morphogenesis (GO:0048813)2.71098888
183innervation (GO:0060384)2.68247232
184long term synaptic depression (GO:0060292)2.67692240
185regulation of ARF protein signal transduction (GO:0032012)2.67246435
186neuromuscular process controlling posture (GO:0050884)2.66689850
187fear response (GO:0042596)2.65650723
188neuronal ion channel clustering (GO:0045161)2.64637483
189regulation of neurotransmitter secretion (GO:0046928)2.63920285
190neuromuscular process (GO:0050905)2.63446622
191regulation of Rap GTPase activity (GO:0032317)2.63419393
192regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.63299417
193regulation of neurotransmitter levels (GO:0001505)2.61474251
194regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.60349625
195visual learning (GO:0008542)2.59411285
196startle response (GO:0001964)2.58787567
197adult walking behavior (GO:0007628)2.56676869
198regulation of synaptic transmission (GO:0050804)2.56267956

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.57384142
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.74998467
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.49141854
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.35211841
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.73506979
6GBX2_23144817_ChIP-Seq_PC3_Human3.46629171
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.17594696
8RUNX_20019798_ChIP-Seq_JUKART_Human3.17203343
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.02721264
10JARID2_20064375_ChIP-Seq_MESCs_Mouse3.02269026
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.94779367
12* IRF8_27001747_Chip-Seq_BMDM_Mouse2.83654844
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.76474033
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72217363
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72217363
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.72067293
17DROSHA_22980978_ChIP-Seq_HELA_Human2.69975205
18IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.64671408
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62016744
20* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.50167538
21SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.48593323
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.46957287
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43219114
24MYB_21317192_ChIP-Seq_ERMYB_Mouse2.39359975
25SCL_19346495_ChIP-Seq_HPC-7_Human2.38380851
26SPI1_23127762_ChIP-Seq_K562_Human2.36022914
27MTF2_20144788_ChIP-Seq_MESCs_Mouse2.34279950
28EED_16625203_ChIP-ChIP_MESCs_Mouse2.33230817
29IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.30073095
30RARB_27405468_Chip-Seq_BRAIN_Mouse2.21885331
31RNF2_27304074_Chip-Seq_ESCs_Mouse2.20325336
32* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.20290524
33* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18490707
34IKZF1_21737484_ChIP-ChIP_HCT116_Human2.16141230
35MYB_26560356_Chip-Seq_TH2_Human2.14826069
36NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.12381775
37SPI1_23547873_ChIP-Seq_NB4_Human2.07208353
38REST_21632747_ChIP-Seq_MESCs_Mouse2.06849692
39VDR_24787735_ChIP-Seq_THP-1_Human2.05834312
40SUZ12_27294783_Chip-Seq_ESCs_Mouse2.03537456
41EZH2_27294783_Chip-Seq_ESCs_Mouse2.00667571
42GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.98076290
43MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.95508490
44Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.92296556
45VDR_24763502_ChIP-Seq_THP-1_Human1.89327646
46ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.86229333
47RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.82782995
48* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.76574221
49AR_21572438_ChIP-Seq_LNCaP_Human1.76427495
50GATA2_21666600_ChIP-Seq_HMVEC_Human1.72052114
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69269604
52SMAD4_21799915_ChIP-Seq_A2780_Human1.67729329
53PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67232808
54GATA3_27048872_Chip-Seq_THYMUS_Human1.67117115
55MYB_26560356_Chip-Seq_TH1_Human1.66651428
56REST_18959480_ChIP-ChIP_MESCs_Mouse1.63226802
57E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.59547629
58VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.58952328
59MAF_26560356_Chip-Seq_TH1_Human1.58767140
60PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58286377
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.58049085
62SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.57492051
63RUNX1_22412390_ChIP-Seq_EML_Mouse1.51936918
64CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51640210
65SMAD_19615063_ChIP-ChIP_OVARY_Human1.49861966
66BRD4_27068464_Chip-Seq_AML-cells_Mouse1.48303236
67STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48101574
68BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47891892
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47757739
70GATA3_26560356_Chip-Seq_TH2_Human1.46440015
71PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46376773
72LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.45866865
73GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.43801378
74UTX_26944678_Chip-Seq_JUKART_Human1.43087278
75* P300_19829295_ChIP-Seq_ESCs_Human1.38717973
76RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.38518535
77LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.38380796
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34422241
79* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.33260900
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.32158927
81TAF15_26573619_Chip-Seq_HEK293_Human1.31782526
82TP53_16413492_ChIP-PET_HCT116_Human1.30549902
83ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30359080
84CTBP1_25329375_ChIP-Seq_LNCAP_Human1.30340676
85NR3C1_23031785_ChIP-Seq_PC12_Mouse1.30015068
86* CBX2_27304074_Chip-Seq_ESCs_Mouse1.29530905
87RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.29249355
88SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29142998
89CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28743657
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28693181
91GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28624869
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.28305326
93AR_19668381_ChIP-Seq_PC3_Human1.27573058
94MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.25943987
95STAT3_23295773_ChIP-Seq_U87_Human1.25208321
96RING1B_27294783_Chip-Seq_ESCs_Mouse1.25200338
97KDM2B_26808549_Chip-Seq_SUP-B15_Human1.23681954
98SOX2_21211035_ChIP-Seq_LN229_Gbm1.22528473
99TCF7_22412390_ChIP-Seq_EML_Mouse1.22437589
100AR_25329375_ChIP-Seq_VCAP_Human1.22103179
101CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.21310195
102PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20395104
103ARNT_22903824_ChIP-Seq_MCF-7_Human1.19862014
104PIAS1_25552417_ChIP-Seq_VCAP_Human1.19142483
105PU_27001747_Chip-Seq_BMDM_Mouse1.18003912
106WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.17935659
107VDR_21846776_ChIP-Seq_THP-1_Human1.17370883
108AHR_22903824_ChIP-Seq_MCF-7_Human1.17250842
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17202539
110ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.15674218
111PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15306325
112TCF4_23295773_ChIP-Seq_U87_Human1.12909402
113YAP1_20516196_ChIP-Seq_MESCs_Mouse1.11028389
114P53_22127205_ChIP-Seq_FIBROBLAST_Human1.10024763
115RING1B_27294783_Chip-Seq_NPCs_Mouse1.09623250
116GATA1_22025678_ChIP-Seq_K562_Human1.08527636
117TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07489677
118ZNF274_21170338_ChIP-Seq_K562_Hela1.06787831
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.06061077
120STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.05744096
121NR3C1_21868756_ChIP-Seq_MCF10A_Human1.05492998
122AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05283928
123ERG_21242973_ChIP-ChIP_JURKAT_Human1.04875195
124RXR_22108803_ChIP-Seq_LS180_Human1.04461281
125VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04060346
126TOP2B_26459242_ChIP-Seq_MCF-7_Human1.03444980
127RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.02891697
128KDM2B_26808549_Chip-Seq_K562_Human1.02348963
129CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.01693294
130GATA1_19941826_ChIP-Seq_K562_Human1.01120069
131TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.01083975
132TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00947544
133GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00244562
134MAF_26560356_Chip-Seq_TH2_Human0.99073044
135TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.98609627
136KDM2B_26808549_Chip-Seq_DND41_Human0.97960174
137DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97820014
138SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97618286
139BMI1_23680149_ChIP-Seq_NPCS_Mouse0.96858187
140POU3F2_20337985_ChIP-ChIP_501MEL_Human0.96808888
141* RUNX2_22187159_ChIP-Seq_PCA_Human0.96787321
142SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96656629
143CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96285345
144MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.96049532
145SMAD3_21741376_ChIP-Seq_HESCs_Human0.95983149
146STAT6_21828071_ChIP-Seq_BEAS2B_Human0.95627285
147SMAD3_21741376_ChIP-Seq_ESCs_Human0.94822206
148GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94288144
149SMRT_27268052_Chip-Seq_Bcells_Human0.94201913
150BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93415571
151EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92896778
152EP300_21415370_ChIP-Seq_HL-1_Mouse0.92653443
153NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92624436
154GATA2_19941826_ChIP-Seq_K562_Human0.92442725
155GATA1_19941827_ChIP-Seq_MEL86_Mouse0.92218202
156UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91164390
157TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91101357
158POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.91101357
159TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.90488331
160SMAD4_21741376_ChIP-Seq_HESCs_Human0.90419783
161GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90201443
162KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90196870
163TP53_18474530_ChIP-ChIP_U2OS_Human0.89958433
164RNF2_27304074_Chip-Seq_NSC_Mouse0.89641490
165TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.89523293
166NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.86997869
167PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84839254
168PRDM14_20953172_ChIP-Seq_ESCs_Human0.83952159
169KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.81946952
170CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.80836771
171RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79591798
172KDM2B_26808549_Chip-Seq_JURKAT_Human0.78777069
173CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.76551477
174EGR1_19374776_ChIP-ChIP_THP-1_Human0.75990737
175TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.73799437
176CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.71994086
177NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.70458872
178NOTCH1_21737748_ChIP-Seq_TLL_Human0.69985674
179ESR1_20079471_ChIP-ChIP_T-47D_Human0.69229716
180GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.68709707
181BCAT_22108803_ChIP-Seq_LS180_Human0.67339115
182TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.67018972
183FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66930762
184STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.64499726
185MYC_22102868_ChIP-Seq_BL_Human0.64021005
186ER_23166858_ChIP-Seq_MCF-7_Human0.63229515

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.45964780
2MP0003724_increased_susceptibility_to6.25238296
3MP0003880_abnormal_central_pattern4.12778519
4MP0003635_abnormal_synaptic_transmissio4.01370637
5MP0003436_decreased_susceptibility_to3.84181502
6MP0001835_abnormal_antigen_presentation3.66904577
7MP0009046_muscle_twitch3.24599270
8MP0009745_abnormal_behavioral_response3.21191994
9MP0002063_abnormal_learning/memory/cond3.16755178
10MP0003122_maternal_imprinting3.10244190
11MP0002419_abnormal_innate_immunity3.05600485
12MP0002064_seizures2.94094990
13MP0001800_abnormal_humoral_immune2.87031617
14MP0005671_abnormal_response_to2.77278152
15MP0001968_abnormal_touch/_nociception2.76021335
16MP0000569_abnormal_digit_pigmentation2.74522788
17MP0002572_abnormal_emotion/affect_behav2.66906346
18MP0005025_abnormal_response_to2.65105264
19MP0005000_abnormal_immune_tolerance2.59383995
20MP0009785_altered_susceptibility_to2.58834194
21MP0004270_analgesia2.58254919
22MP0003828_pulmonary_edema2.54378161
23MP0001486_abnormal_startle_reflex2.53849225
24MP0002723_abnormal_immune_serum2.50642837
25MP0002420_abnormal_adaptive_immunity2.46684524
26MP0000685_abnormal_immune_system2.45418029
27MP0002822_catalepsy2.44277067
28MP0001819_abnormal_immune_cell2.43495592
29MP0005387_immune_system_phenotype2.42198303
30MP0001790_abnormal_immune_system2.42198303
31MP0001501_abnormal_sleep_pattern2.38595870
32MP0005423_abnormal_somatic_nervous2.36309651
33MP0002452_abnormal_antigen_presenting2.35958713
34MP0002272_abnormal_nervous_system2.26894653
35MP0006082_CNS_inflammation2.26735112
36MP0003763_abnormal_thymus_physiology2.26663641
37MP0000465_gastrointestinal_hemorrhage2.23189408
38MP0003300_gastrointestinal_ulcer2.22188826
39MP0001533_abnormal_skeleton_physiology2.15347600
40MP0003787_abnormal_imprinting2.04524244
41MP0002736_abnormal_nociception_after2.03201841
42MP0002405_respiratory_system_inflammati2.01669838
43MP0002735_abnormal_chemical_nociception1.98058161
44MP0005464_abnormal_platelet_physiology1.94459670
45MP0008260_abnormal_autophagy1.90592685
46MP0002734_abnormal_mechanical_nocicepti1.89002636
47MP0008569_lethality_at_weaning1.87216198
48MP0002148_abnormal_hypersensitivity_rea1.84206312
49MP0002398_abnormal_bone_marrow1.82375777
50MP0000716_abnormal_immune_system1.79987602
51MP0003191_abnormal_cellular_cholesterol1.79551806
52MP0002132_abnormal_respiratory_system1.77361754
53MP0009780_abnormal_chondrocyte_physiolo1.77278854
54MP0002067_abnormal_sensory_capabilities1.74539435
55MP0001970_abnormal_pain_threshold1.67574585
56MP0005646_abnormal_pituitary_gland1.65144482
57MP0002557_abnormal_social/conspecific_i1.63992163
58MP0001440_abnormal_grooming_behavior1.62275276
59MP0003866_abnormal_defecation1.61520195
60MP0005409_darkened_coat_color1.60536086
61MP0002733_abnormal_thermal_nociception1.59255938
62MP0004381_abnormal_hair_follicle1.58450923
63MP0002277_abnormal_respiratory_mucosa1.56423592
64MP0006054_spinal_hemorrhage1.55741284
65MP0009764_decreased_sensitivity_to1.55189645
66MP0009278_abnormal_bone_marrow1.54767956
67MP0003121_genomic_imprinting1.54693803
68MP0005167_abnormal_blood-brain_barrier1.53958722
69MP0002166_altered_tumor_susceptibility1.53005839
70MP0001845_abnormal_inflammatory_respons1.51941802
71MP0000689_abnormal_spleen_morphology1.51460185
72MP0002396_abnormal_hematopoietic_system1.50500826
73MP0004811_abnormal_neuron_physiology1.50363233
74MP0002722_abnormal_immune_system1.49909614
75MP0006276_abnormal_autonomic_nervous1.46555649
76MP0000778_abnormal_nervous_system1.45929822
77MP0005386_behavior/neurological_phenoty1.45719054
78MP0004924_abnormal_behavior1.45719054
79MP0010155_abnormal_intestine_physiology1.45368917
80MP0003183_abnormal_peptide_metabolism1.45000466
81MP0000703_abnormal_thymus_morphology1.44697847
82MP0002184_abnormal_innervation1.44678418
83MP0003123_paternal_imprinting1.44480617
84MP0002009_preneoplasia1.42474257
85MP0003303_peritoneal_inflammation1.40234616
86MP0005645_abnormal_hypothalamus_physiol1.38165979
87MP0003633_abnormal_nervous_system1.38087503
88MP0002429_abnormal_blood_cell1.36041043
89MP0005164_abnormal_response_to1.33836083
90MP0003075_altered_response_to1.27698867
91MP0004145_abnormal_muscle_electrophysio1.25375729
92MP0002909_abnormal_adrenal_gland1.24701725
93MP0004130_abnormal_muscle_cell1.24434343
94MP0001188_hyperpigmentation1.23433323
95MP0001529_abnormal_vocalization1.21083356
96MP0003172_abnormal_lysosome_physiology1.19544934
97MP0000955_abnormal_spinal_cord1.19497261
98MP0002066_abnormal_motor_capabilities/c1.18723621
99MP0005310_abnormal_salivary_gland1.15737454
100MP0004947_skin_inflammation1.13021534
101MP0002882_abnormal_neuron_morphology1.12840568
102MP0003631_nervous_system_phenotype1.12075503
103MP0008469_abnormal_protein_level1.11452938
104MP0002998_abnormal_bone_remodeling1.10343902
105MP0003283_abnormal_digestive_organ1.08861577
106MP0000858_altered_metastatic_potential1.08681564
107MP0001177_atelectasis1.04991418
108MP0003879_abnormal_hair_cell1.04904654
109MP0003690_abnormal_glial_cell1.01473028
110MP0008961_abnormal_basal_metabolism1.00749811
111MP0009333_abnormal_splenocyte_physiolog1.00195332
112MP0002152_abnormal_brain_morphology0.99769694
113MP0008874_decreased_physiological_sensi0.99134366
114MP0004085_abnormal_heartbeat0.98180502
115MP0005397_hematopoietic_system_phenotyp0.98044303
116MP0001545_abnormal_hematopoietic_system0.98044303
117MP0002006_tumorigenesis0.97190334
118MP0005075_abnormal_melanosome_morpholog0.96909444
119MP0004885_abnormal_endolymph0.93408082
120MP0004858_abnormal_nervous_system0.93339916
121MP0002933_joint_inflammation0.91464711
122MP0005390_skeleton_phenotype0.91433683
123MP0004510_myositis0.90749621
124MP0000249_abnormal_blood_vessel0.87826866
125MP0001502_abnormal_circadian_rhythm0.85374445
126MP0002837_dystrophic_cardiac_calcinosis0.83772045
127MP0003329_amyloid_beta_deposits0.82897115
128MP0005166_decreased_susceptibility_to0.82348714
129MP0001958_emphysema0.82127640
130MP0003448_altered_tumor_morphology0.81084817
131MP0004142_abnormal_muscle_tone0.80431909
132MP0004808_abnormal_hematopoietic_stem0.80335358
133MP0004742_abnormal_vestibular_system0.78985129
134MP0004215_abnormal_myocardial_fiber0.78787211
135MP0001986_abnormal_taste_sensitivity0.77563144
136MP0001905_abnormal_dopamine_level0.76814903
137MP0000920_abnormal_myelination0.74864056
138MP0005623_abnormal_meninges_morphology0.74496873
139MP0000751_myopathy0.73773724
140MP0003137_abnormal_impulse_conducting0.73597928
141MP0002928_abnormal_bile_duct0.73489825
142MP0003632_abnormal_nervous_system0.73212539
143MP0002332_abnormal_exercise_endurance0.73125409
144MP0002089_abnormal_postnatal_growth/wei0.72248504
145MP0001663_abnormal_digestive_system0.71958238
146MP0005451_abnormal_body_composition0.70001273
147MP0001879_abnormal_lymphatic_vessel0.69645241
148MP0004484_altered_response_of0.69156394
149MP0005535_abnormal_body_temperature0.68906959
150MP0002069_abnormal_eating/drinking_beha0.68853966
151MP0004883_abnormal_blood_vessel0.68754229
152MP0003385_abnormal_body_wall0.68743539
153MP0001943_abnormal_respiration0.67966952
154MP0000767_abnormal_smooth_muscle0.67782389
155MP0008004_abnormal_stomach_pH0.65328695
156MP0009763_increased_sensitivity_to0.64329026
157MP0002168_other_aberrant_phenotype0.64099742
158MP0003279_aneurysm0.63464797
159MP0000343_altered_response_to0.62933318
160MP0001963_abnormal_hearing_physiology0.61710495
161MP0005171_absent_coat_pigmentation0.61667612
162MP0000631_abnormal_neuroendocrine_gland0.60196485
163MP0005388_respiratory_system_phenotype0.60017906
164MP0002133_abnormal_respiratory_system0.60017906
165MP0000604_amyloidosis0.58951360
166MP0010368_abnormal_lymphatic_system0.58147832
167MP0001984_abnormal_olfaction0.57733567
168MP0003045_fibrosis0.57165827
169MP0003878_abnormal_ear_physiology0.57122849
170MP0005377_hearing/vestibular/ear_phenot0.57122849
171MP0002102_abnormal_ear_morphology0.56048217
172MP0003938_abnormal_ear_development0.56032471
173MP0001851_eye_inflammation0.54648348
174MP0001485_abnormal_pinna_reflex0.54367529
175MP0002127_abnormal_cardiovascular_syste0.54139869
176MP0005174_abnormal_tail_pigmentation0.53907477
177MP0005595_abnormal_vascular_smooth0.53807272
178MP0001299_abnormal_eye_distance/0.53249341
179MP0003634_abnormal_glial_cell0.52910051
180MP0000015_abnormal_ear_pigmentation0.52565503
181MP0003861_abnormal_nervous_system0.49492267

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.58706961
2Myositis (HP:0100614)6.27211202
3Orchitis (HP:0100796)6.03706074
4Retrobulbar optic neuritis (HP:0100654)5.84619117
5Optic neuritis (HP:0100653)5.84619117
6Stomatitis (HP:0010280)5.41404814
7Myokymia (HP:0002411)5.25671244
8Focal seizures (HP:0007359)4.97900468
9Elevated erythrocyte sedimentation rate (HP:0003565)4.97387180
10Spontaneous hematomas (HP:0007420)4.74356018
11Abnormality of macrophages (HP:0004311)4.46911199
12Keratoconjunctivitis sicca (HP:0001097)4.30677499
13Gastrointestinal infarctions (HP:0005244)4.25503581
14Hypochromic microcytic anemia (HP:0004840)4.21631369
15Progressive cerebellar ataxia (HP:0002073)4.19868093
16Recurrent fungal infections (HP:0002841)4.17300538
17Papilledema (HP:0001085)4.15394757
18Keratoconjunctivitis (HP:0001096)4.06684313
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.87838957
20Encephalitis (HP:0002383)3.84135417
21Action tremor (HP:0002345)3.84119459
22Recurrent skin infections (HP:0001581)3.81535158
23Febrile seizures (HP:0002373)3.78860532
24T lymphocytopenia (HP:0005403)3.77399232
25Epileptic encephalopathy (HP:0200134)3.76069180
26Visual hallucinations (HP:0002367)3.74989806
27Abnormality of T cell number (HP:0011839)3.62452558
28Meningitis (HP:0001287)3.61738681
29Recurrent cutaneous fungal infections (HP:0011370)3.61240518
30Chronic mucocutaneous candidiasis (HP:0002728)3.61240518
31Atonic seizures (HP:0010819)3.57540158
32Mediastinal lymphadenopathy (HP:0100721)3.56480247
33Hemoptysis (HP:0002105)3.52611964
34Peritonitis (HP:0002586)3.51645918
35Chest pain (HP:0100749)3.50116915
36Broad-based gait (HP:0002136)3.45124478
37Gingivitis (HP:0000230)3.42805458
38Prolonged bleeding time (HP:0003010)3.38091838
39Generalized tonic-clonic seizures (HP:0002069)3.29316870
40Arterial thrombosis (HP:0004420)3.28185126
41Vasculitis (HP:0002633)3.22385405
42Genetic anticipation (HP:0003743)3.20733059
43Gaze-evoked nystagmus (HP:0000640)3.20026418
44Absence seizures (HP:0002121)3.17361308
45Episodic fever (HP:0001954)3.16896686
46Hypochromic anemia (HP:0001931)3.16380571
47Hemiplegia (HP:0002301)3.13319472
48Gingival bleeding (HP:0000225)3.09483788
49Urticaria (HP:0001025)3.05576023
50Pulmonary infiltrates (HP:0002113)3.04652656
51Pulmonary embolism (HP:0002204)3.03885569
52Leukocytosis (HP:0001974)3.00386591
53Impaired smooth pursuit (HP:0007772)2.91643795
54Increased IgE level (HP:0003212)2.90798678
55Dialeptic seizures (HP:0011146)2.86405555
56Epistaxis (HP:0000421)2.83865283
57Microcytic anemia (HP:0001935)2.83777644
58Annular pancreas (HP:0001734)2.79349304
59Poor eye contact (HP:0000817)2.77461329
60Abnormality of T cells (HP:0002843)2.76744999
61Dysdiadochokinesis (HP:0002075)2.74176226
62Anorexia (HP:0002039)2.69350182
63Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.66218668
64Truncal ataxia (HP:0002078)2.62916233
65Pointed chin (HP:0000307)2.62730229
66Cellulitis (HP:0100658)2.61295823
67Dysmetria (HP:0001310)2.60907868
68Stereotypic behavior (HP:0000733)2.58844854
69Depression (HP:0000716)2.56866088
70Amyloidosis (HP:0011034)2.56415686
71Urinary bladder sphincter dysfunction (HP:0002839)2.53548277
72Abnormality of the pleura (HP:0002103)2.50039355
73Postural instability (HP:0002172)2.49610086
74Impaired vibration sensation in the lower limbs (HP:0002166)2.48093952
75Hematochezia (HP:0002573)2.46644996
76Abnormal eating behavior (HP:0100738)2.45625291
77Abnormality of ocular smooth pursuit (HP:0000617)2.43317372
78Abnormality of the peritoneum (HP:0002585)2.38965341
79Abnormal social behavior (HP:0012433)2.38461054
80Impaired social interactions (HP:0000735)2.38461054
81Inflammation of the large intestine (HP:0002037)2.37525486
82Abnormality of the endocardium (HP:0004306)2.36591613
83Pustule (HP:0200039)2.35712259
84Subacute progressive viral hepatitis (HP:0006572)2.35671996
85Dysmetric saccades (HP:0000641)2.35229278
86Gangrene (HP:0100758)2.33691386
87Short 4th metacarpal (HP:0010044)2.31694407
88Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.31694407
89Vertigo (HP:0002321)2.31322912
90Ankyloglossia (HP:0010296)2.30761771
91Diplopia (HP:0000651)2.29212056
92Abnormality of binocular vision (HP:0011514)2.29212056
93Anxiety (HP:0000739)2.27600266
94Obstructive sleep apnea (HP:0002870)2.25152785
95Granulocytopenia (HP:0001913)2.24506368
96Keratitis (HP:0000491)2.23895289
97Supranuclear gaze palsy (HP:0000605)2.22890074
98Eosinophilia (HP:0001880)2.21363069
99Panhypogammaglobulinemia (HP:0003139)2.18857584
100Aqueductal stenosis (HP:0002410)2.18710606
101Increased IgM level (HP:0003496)2.17601649
102Gastrointestinal inflammation (HP:0004386)2.17143704
103Osteomyelitis (HP:0002754)2.16901192
104Stomach cancer (HP:0012126)2.15534571
105Drooling (HP:0002307)2.14348685
106Excessive salivation (HP:0003781)2.14348685
107Eczematoid dermatitis (HP:0000976)2.13814524
108Scanning speech (HP:0002168)2.13813557
109Recurrent viral infections (HP:0004429)2.13762302
110Ankle clonus (HP:0011448)2.11707537
111Amblyopia (HP:0000646)2.10958309
112Recurrent abscess formation (HP:0002722)2.10199692
113Sepsis (HP:0100806)2.10022849
114Absent speech (HP:0001344)2.09544220
115Agitation (HP:0000713)2.08830594
116Abnormality of the pericardium (HP:0001697)2.07258010
117Hyperventilation (HP:0002883)2.04351024
118Acne (HP:0001061)2.03484919
119Inappropriate behavior (HP:0000719)2.03068035
120Abnormality of T cell physiology (HP:0011840)2.01916428
121Abnormality of eosinophils (HP:0001879)2.00590867
122Abnormal platelet volume (HP:0011876)1.98641101
123Recurrent gram-negative bacterial infections (HP:0005420)1.98594147
124Obsessive-compulsive behavior (HP:0000722)1.97990637
125Glomerulopathy (HP:0100820)1.97753391
126Viral hepatitis (HP:0006562)1.97723851
127Spinal canal stenosis (HP:0003416)1.96223541
128Lymphopenia (HP:0001888)1.94131475
129Thrombophlebitis (HP:0004418)1.92898465
130Polycythemia (HP:0001901)1.92511450
131Narrow palate (HP:0000189)1.91844362
132Absent frontal sinuses (HP:0002688)1.91485715
133Mutism (HP:0002300)1.89025775
134Difficulty running (HP:0009046)1.88844044
135Intention tremor (HP:0002080)1.88294143
136Macroorchidism (HP:0000053)1.87486540
137Hemiparesis (HP:0001269)1.87242987
138Torticollis (HP:0000473)1.85908830
139Incomplete penetrance (HP:0003829)1.85364221
140Slow saccadic eye movements (HP:0000514)1.85227115
141Abnormal EKG (HP:0003115)1.84807124
142Recurrent bronchitis (HP:0002837)1.83739453
143Amaurosis fugax (HP:0100576)1.82721485
144Lower limb amyotrophy (HP:0007210)1.81507627
145Ventricular fibrillation (HP:0001663)1.80672840
146Abnormality of oral frenula (HP:0000190)1.80060692
147Widely spaced teeth (HP:0000687)1.80028016
148Cheilitis (HP:0100825)1.79841523
149Tented upper lip vermilion (HP:0010804)1.79073325
150Hip dysplasia (HP:0001385)1.79013752
151Urinary urgency (HP:0000012)1.78966326
152Abnormality of cells of the lymphoid lineage (HP:0012140)1.78882759
153Neoplasm of the tracheobronchial system (HP:0100552)1.77877420
154Arterial tortuosity (HP:0005116)1.76884877
155Obstructive lung disease (HP:0006536)1.76016620
156Chronic obstructive pulmonary disease (HP:0006510)1.76016620
157Prolonged QT interval (HP:0001657)1.75529974
158Narrow nasal bridge (HP:0000446)1.74732661
159Abnormality of the right ventricle (HP:0001707)1.74225347
160Facial diplegia (HP:0001349)1.74048568
161Hypergammaglobulinemia (HP:0010702)1.73686581
162Skin ulcer (HP:0200042)1.72253969
163Lower limb asymmetry (HP:0100559)1.71150839
164IgG deficiency (HP:0004315)1.71047415
165Epileptiform EEG discharges (HP:0011182)1.70279116
166Protruding tongue (HP:0010808)1.70138240
167Abnormality of saccadic eye movements (HP:0000570)1.69846659
168Petechiae (HP:0000967)1.69182155
169Polyneuropathy (HP:0001271)1.68455337
170Recurrent bacterial skin infections (HP:0005406)1.67462545
171Elfin facies (HP:0004428)1.66036620
172Paresthesia (HP:0003401)1.65807402
173Recurrent pneumonia (HP:0006532)1.65404986
174Toxemia of pregnancy (HP:0100603)1.65108809
175Abnormality of the lower motor neuron (HP:0002366)1.64824808
176Hyperacusis (HP:0010780)1.64533376
177Exotropia (HP:0000577)1.64363953
178Bradykinesia (HP:0002067)1.64097486
179Deeply set eye (HP:0000490)1.63872116
180Renal duplication (HP:0000075)1.63641784
181Impaired vibratory sensation (HP:0002495)1.63359335
182Atrial fibrillation (HP:0005110)1.62484715
183IgM deficiency (HP:0002850)1.62222993
184Primary atrial arrhythmia (HP:0001692)1.62214458
185Autism (HP:0000717)1.62173326
186Abnormality of salivation (HP:0100755)1.61905180
187Chronic otitis media (HP:0000389)1.61800715
188Focal dystonia (HP:0004373)1.61672168
189Decreased circulating renin level (HP:0003351)1.61603655
190Cerebral aneurysm (HP:0004944)1.61254381
191Insomnia (HP:0100785)1.61106965
192Colitis (HP:0002583)1.60231024

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.93504723
2EPHA44.24067372
3MAP3K93.18744259
4MAP4K13.00129113
5CSK2.74923625
6FES2.66818870
7MAP2K32.64321858
8RIPK42.43157015
9TYK22.35632879
10MINK12.26497924
11TXK2.25604146
12MAP3K42.23264683
13DAPK22.21902636
14GRK62.16258027
15ZAP702.11583756
16EPHB12.05468958
17CAMKK12.04699768
18MAP3K122.02706971
19KSR11.97752868
20CAMK1G1.95766494
21SIK31.93145379
22BTK1.91139932
23NTRK21.84841355
24TAOK31.82229764
25DMPK1.80690677
26JAK31.78592245
27SYK1.76718730
28SIK21.70063938
29PRKD31.62774229
30ERN11.62603381
31KSR21.62280008
32PAK61.61443537
33DAPK11.59622932
34TEC1.57013530
35FRK1.56248705
36YES11.52088308
37MAP3K31.50906967
38ITK1.49863815
39TNIK1.47464407
40MAP2K71.47065571
41CASK1.46248750
42IRAK11.45609923
43PRPF4B1.43363684
44IKBKE1.42876816
45CAMKK21.40093202
46MAP3K131.40041651
47TIE11.35923911
48JAK21.35021979
49JAK11.31737351
50MAP2K41.31662378
51LYN1.29821301
52CDK51.29111094
53NLK1.29100294
54MAPK131.28592353
55NTRK11.23794190
56STK381.23147651
57RIPK11.22323459
58SGK21.21361827
59CAMK1D1.21065725
60SGK31.19789916
61PTK2B1.19683852
62TGFBR21.18164409
63LCK1.17591826
64CAMK11.15689196
65PRKCH1.14219446
66PIK3CG1.13752742
67MARK11.12552084
68EPHA31.12423638
69KIT1.09326584
70MAP3K141.04331624
71PLK21.01046409
72SGK2231.00679788
73SGK4941.00679788
74STK110.99693749
75UHMK10.99015117
76MAP3K110.96399792
77SGK10.91553247
78MATK0.91214988
79TAOK10.91047425
80PRKCG0.90258523
81ALK0.88041009
82CSF1R0.87515874
83PNCK0.86780537
84IRAK20.85660221
85FGFR30.85513310
86TNK20.84817935
87MARK30.84679914
88CAMK2A0.82721840
89CDK190.82416566
90GRK50.80151985
91MARK20.79692402
92PTK60.79598271
93WNK10.78406651
94CAMK40.78334554
95IRAK40.78218022
96STK100.76781149
97LRRK20.74751086
98RAF10.74251479
99TYRO30.73734975
100CDC42BPA0.73524995
101CLK10.71494785
102MAP3K60.71335488
103PDK10.71176613
104CDK180.70270560
105MAPK70.70054741
106PDPK10.69821721
107BRSK10.69521434
108FYN0.68245778
109HIPK20.66464367
110FGR0.63662457
111MAP3K20.63376421
112CDK150.62429886
113TBK10.61942326
114PRKCQ0.61794726
115CAMK2B0.60800747
116CDK140.55821309
117IKBKB0.53889751
118MAPK120.53402049
119RPS6KA20.52440374
120RPS6KA30.50708703
121ERBB30.50684049
122RET0.50321059
123CDK11A0.50255553
124MAP3K70.50189303
125NEK60.47047288
126PIM10.46283777
127ADRBK10.46089320
128ACVR1B0.45958778
129RPS6KA60.45132421
130BMX0.44423898
131MAPK100.43838147
132ARAF0.43479029
133PRKD20.42548471
134HCK0.41968698
135INSRR0.41671949
136ROCK20.41280485
137PRKG10.39796501
138MAP3K10.39492602
139RPS6KC10.39422260
140RPS6KL10.39422260
141BLK0.39388317
142PRKCB0.39306918
143DYRK1B0.38012078
144KDR0.37630728
145SRC0.37522193
146PTK20.36009312
147PDGFRB0.35889040
148PRKCE0.35194485
149BMPR20.33986801
150WNK30.33621133
151PRKCZ0.32779595
152EPHB20.32716707
153OXSR10.31670825
154DYRK1A0.31231661
155FGFR10.31185257

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.29670897
2Circadian entrainment_Homo sapiens_hsa047132.55199059
3Long-term potentiation_Homo sapiens_hsa047202.48435780
4Olfactory transduction_Homo sapiens_hsa047402.47677009
5Morphine addiction_Homo sapiens_hsa050322.45448751
6Glutamatergic synapse_Homo sapiens_hsa047242.35635883
7Staphylococcus aureus infection_Homo sapiens_hsa051502.34538650
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.34022510
9GABAergic synapse_Homo sapiens_hsa047272.21045056
10Synaptic vesicle cycle_Homo sapiens_hsa047212.18683902
11Amphetamine addiction_Homo sapiens_hsa050312.17812160
12Salivary secretion_Homo sapiens_hsa049702.07866194
13B cell receptor signaling pathway_Homo sapiens_hsa046622.05002644
14Malaria_Homo sapiens_hsa051441.99568570
15Dopaminergic synapse_Homo sapiens_hsa047281.92722717
16Graft-versus-host disease_Homo sapiens_hsa053321.86520602
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.85087030
18Primary immunodeficiency_Homo sapiens_hsa053401.82321290
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.81135103
20T cell receptor signaling pathway_Homo sapiens_hsa046601.77696655
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.77607850
22Allograft rejection_Homo sapiens_hsa053301.75243327
23Cholinergic synapse_Homo sapiens_hsa047251.74580755
24Measles_Homo sapiens_hsa051621.72314901
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.68846870
26Insulin secretion_Homo sapiens_hsa049111.68390650
27Autoimmune thyroid disease_Homo sapiens_hsa053201.68199286
28Gastric acid secretion_Homo sapiens_hsa049711.67656850
29Long-term depression_Homo sapiens_hsa047301.66881752
30Renin secretion_Homo sapiens_hsa049241.65920845
31Cocaine addiction_Homo sapiens_hsa050301.65084915
32Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62708743
33Serotonergic synapse_Homo sapiens_hsa047261.59295954
34Oxytocin signaling pathway_Homo sapiens_hsa049211.58214384
35Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.58035379
36Taste transduction_Homo sapiens_hsa047421.55057169
37Calcium signaling pathway_Homo sapiens_hsa040201.52739568
38Hematopoietic cell lineage_Homo sapiens_hsa046401.47496720
39cAMP signaling pathway_Homo sapiens_hsa040241.44665122
40Jak-STAT signaling pathway_Homo sapiens_hsa046301.40589961
41Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40165740
42Acute myeloid leukemia_Homo sapiens_hsa052211.39686484
43Type II diabetes mellitus_Homo sapiens_hsa049301.38411083
44NF-kappa B signaling pathway_Homo sapiens_hsa040641.36722381
45Toxoplasmosis_Homo sapiens_hsa051451.31472308
46GnRH signaling pathway_Homo sapiens_hsa049121.30627872
47Legionellosis_Homo sapiens_hsa051341.26694561
48Gap junction_Homo sapiens_hsa045401.25749533
49Type I diabetes mellitus_Homo sapiens_hsa049401.24321930
50Estrogen signaling pathway_Homo sapiens_hsa049151.21619311
51Influenza A_Homo sapiens_hsa051641.19801166
52Antigen processing and presentation_Homo sapiens_hsa046121.19641952
53cGMP-PKG signaling pathway_Homo sapiens_hsa040221.17357421
54Glioma_Homo sapiens_hsa052141.17021453
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15916885
56Axon guidance_Homo sapiens_hsa043601.14162306
57TNF signaling pathway_Homo sapiens_hsa046681.12268470
58Phagosome_Homo sapiens_hsa041451.10483860
59Viral myocarditis_Homo sapiens_hsa054161.09580507
60Phosphatidylinositol signaling system_Homo sapiens_hsa040701.09130858
61Melanogenesis_Homo sapiens_hsa049161.08933630
62Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.08836817
63RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.08158360
64Hepatitis B_Homo sapiens_hsa051611.07132947
65Dorso-ventral axis formation_Homo sapiens_hsa043201.01077977
66Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00921253
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98412344
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.97509571
69Vascular smooth muscle contraction_Homo sapiens_hsa042700.96745459
70Intestinal immune network for IgA production_Homo sapiens_hsa046720.96390756
71Dilated cardiomyopathy_Homo sapiens_hsa054140.94300863
72Pancreatic cancer_Homo sapiens_hsa052120.93753054
73Herpes simplex infection_Homo sapiens_hsa051680.92297352
74Prolactin signaling pathway_Homo sapiens_hsa049170.91825842
75Rap1 signaling pathway_Homo sapiens_hsa040150.91536881
76Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91245150
77Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.90923033
78FoxO signaling pathway_Homo sapiens_hsa040680.89283230
79Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.89125531
80Neurotrophin signaling pathway_Homo sapiens_hsa047220.89069575
81ErbB signaling pathway_Homo sapiens_hsa040120.85870919
82Chronic myeloid leukemia_Homo sapiens_hsa052200.84601300
83Hepatitis C_Homo sapiens_hsa051600.84080966
84Thyroid hormone synthesis_Homo sapiens_hsa049180.84010251
85Chemokine signaling pathway_Homo sapiens_hsa040620.83857375
86Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.83605450
87Oocyte meiosis_Homo sapiens_hsa041140.83532351
88Pancreatic secretion_Homo sapiens_hsa049720.83167437
89Platelet activation_Homo sapiens_hsa046110.83146960
90MAPK signaling pathway_Homo sapiens_hsa040100.82762192
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82223970
92Choline metabolism in cancer_Homo sapiens_hsa052310.79156761
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.78908276
94Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.78093373
95Asthma_Homo sapiens_hsa053100.77879334
96Regulation of autophagy_Homo sapiens_hsa041400.77453738
97AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77103899
98Pertussis_Homo sapiens_hsa051330.76772867
99Apoptosis_Homo sapiens_hsa042100.75230217
100Notch signaling pathway_Homo sapiens_hsa043300.74262654
101Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.73886375
102VEGF signaling pathway_Homo sapiens_hsa043700.72826303
103Carbohydrate digestion and absorption_Homo sapiens_hsa049730.72735600
104Shigellosis_Homo sapiens_hsa051310.68659226
105Non-small cell lung cancer_Homo sapiens_hsa052230.68636514
106Salmonella infection_Homo sapiens_hsa051320.68610454
107Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.68384070
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.66055000
109Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.63983107
110SNARE interactions in vesicular transport_Homo sapiens_hsa041300.63785378
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63124107
112Sphingolipid signaling pathway_Homo sapiens_hsa040710.62741283
113Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62382752
114Rheumatoid arthritis_Homo sapiens_hsa053230.62306007
115Ras signaling pathway_Homo sapiens_hsa040140.61050969
116Amoebiasis_Homo sapiens_hsa051460.60441875
117Wnt signaling pathway_Homo sapiens_hsa043100.59318743
118Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58526183
119Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.57867875
120Endocytosis_Homo sapiens_hsa041440.57847370
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.57540135
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.56175118
123Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.55548546
124Inositol phosphate metabolism_Homo sapiens_hsa005620.55430438
125HIF-1 signaling pathway_Homo sapiens_hsa040660.55286288
126Ovarian steroidogenesis_Homo sapiens_hsa049130.55156839
127Adipocytokine signaling pathway_Homo sapiens_hsa049200.55072985
128Glucagon signaling pathway_Homo sapiens_hsa049220.54063381
129Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52893398
130mTOR signaling pathway_Homo sapiens_hsa041500.52680330
131Transcriptional misregulation in cancer_Homo sapiens_hsa052020.52401153
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.51526248
133Collecting duct acid secretion_Homo sapiens_hsa049660.51474718
134Insulin resistance_Homo sapiens_hsa049310.51313728
135Osteoclast differentiation_Homo sapiens_hsa043800.50953605
136Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49820547
137Proteoglycans in cancer_Homo sapiens_hsa052050.49634567
138Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49149410
139Prostate cancer_Homo sapiens_hsa052150.48975889
140Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48670722
141African trypanosomiasis_Homo sapiens_hsa051430.48275106
142Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47024175
143Renal cell carcinoma_Homo sapiens_hsa052110.46966718
144Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46203860
145Leishmaniasis_Homo sapiens_hsa051400.45406166
146Endometrial cancer_Homo sapiens_hsa052130.43946903
147Focal adhesion_Homo sapiens_hsa045100.42906627
148Alcoholism_Homo sapiens_hsa050340.42188123
149Tuberculosis_Homo sapiens_hsa051520.41992067
150Cardiac muscle contraction_Homo sapiens_hsa042600.41698609
151Colorectal cancer_Homo sapiens_hsa052100.40843182
152Insulin signaling pathway_Homo sapiens_hsa049100.37225252

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