NICN1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This protein encoded by this gene localizes to the nucleus and is expressed in numerous tissues including brain, testis, liver, and kidney. This refseq contains genomic sequence in its 3' UTR which is not supported by experimental evidence. Computer predictions indicate that this region of the 3' UTR contains hairpin-forming self-complementary sequence which is possibly excised after transcription. This gene has a pseudogene on chromosome X. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1behavioral response to nicotine (GO:0035095)5.53225952
2synaptic vesicle exocytosis (GO:0016079)5.18334697
3neuron cell-cell adhesion (GO:0007158)5.12641907
4vocalization behavior (GO:0071625)5.10235994
5regulation of short-term neuronal synaptic plasticity (GO:0048172)4.93286807
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.70566591
7glutamate secretion (GO:0014047)4.66892602
8protein localization to synapse (GO:0035418)4.59366872
9positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.45856012
10regulation of synaptic vesicle exocytosis (GO:2000300)4.42460456
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.39019816
12fucose catabolic process (GO:0019317)4.26477941
13L-fucose metabolic process (GO:0042354)4.26477941
14L-fucose catabolic process (GO:0042355)4.26477941
15regulation of glutamate receptor signaling pathway (GO:1900449)4.25524601
16neuronal action potential propagation (GO:0019227)4.14534997
17synaptic vesicle docking involved in exocytosis (GO:0016081)4.10850074
18neurotransmitter secretion (GO:0007269)4.08293221
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.00342013
20neuron recognition (GO:0008038)3.97355697
21ionotropic glutamate receptor signaling pathway (GO:0035235)3.94462108
22synaptic vesicle maturation (GO:0016188)3.90814595
23regulation of synaptic vesicle transport (GO:1902803)3.88802511
24presynaptic membrane assembly (GO:0097105)3.87928292
25epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.84003045
26neuron-neuron synaptic transmission (GO:0007270)3.81283702
27negative regulation of synaptic transmission, GABAergic (GO:0032229)3.79940397
28protein polyglutamylation (GO:0018095)3.73978223
29response to pheromone (GO:0019236)3.72640405
30synaptic transmission, glutamatergic (GO:0035249)3.72620355
31glutamate receptor signaling pathway (GO:0007215)3.71488131
32DNA deamination (GO:0045006)3.70741001
33regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.67723979
34postsynaptic membrane organization (GO:0001941)3.66598170
35presynaptic membrane organization (GO:0097090)3.64406457
36water-soluble vitamin biosynthetic process (GO:0042364)3.63866358
37locomotory exploration behavior (GO:0035641)3.60963690
38neurotransmitter-gated ion channel clustering (GO:0072578)3.59112593
39cellular ketone body metabolic process (GO:0046950)3.58342012
40gamma-aminobutyric acid signaling pathway (GO:0007214)3.57891390
41axonal fasciculation (GO:0007413)3.47924024
42gamma-aminobutyric acid transport (GO:0015812)3.45821285
43neurotransmitter transport (GO:0006836)3.44879549
44regulation of long-term neuronal synaptic plasticity (GO:0048169)3.44135693
45regulation of neuronal synaptic plasticity (GO:0048168)3.42639424
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.40451454
47exploration behavior (GO:0035640)3.39664264
48epithelial cilium movement (GO:0003351)3.34684202
49nucleobase catabolic process (GO:0046113)3.34375871
50negative regulation of telomere maintenance (GO:0032205)3.32062233
51cell migration in hindbrain (GO:0021535)3.30940888
52layer formation in cerebral cortex (GO:0021819)3.28855412
53regulation of excitatory postsynaptic membrane potential (GO:0060079)3.26874318
54protein complex biogenesis (GO:0070271)3.23867737
55negative regulation of microtubule polymerization (GO:0031115)3.21239167
56transmission of nerve impulse (GO:0019226)3.20332110
57regulation of glutamate secretion (GO:0014048)3.19539461
58negative regulation of dendrite morphogenesis (GO:0050774)3.19530322
59synaptic vesicle endocytosis (GO:0048488)3.19129936
60negative regulation of cytosolic calcium ion concentration (GO:0051481)3.18800277
61regulation of action potential (GO:0098900)3.18302957
62positive regulation of membrane potential (GO:0045838)3.18192000
63ketone body metabolic process (GO:1902224)3.17987973
64preassembly of GPI anchor in ER membrane (GO:0016254)3.17468084
65proline transport (GO:0015824)3.17231395
66regulation of postsynaptic membrane potential (GO:0060078)3.17177028
67regulation of neurotransmitter levels (GO:0001505)3.16831510
68positive regulation of synapse assembly (GO:0051965)3.15446260
69regulation of neurotransmitter secretion (GO:0046928)3.15237507
70indole-containing compound catabolic process (GO:0042436)3.15203416
71indolalkylamine catabolic process (GO:0046218)3.15203416
72tryptophan catabolic process (GO:0006569)3.15203416
73positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.14582121
74synapse assembly (GO:0007416)3.13846441
75female mating behavior (GO:0060180)3.13296235
76startle response (GO:0001964)3.12530843
77dendritic spine morphogenesis (GO:0060997)3.11698026
78regulation of cilium movement (GO:0003352)3.11610096
79regulation of vesicle fusion (GO:0031338)3.11179072
80mitochondrial respiratory chain complex I assembly (GO:0032981)3.10757838
81NADH dehydrogenase complex assembly (GO:0010257)3.10757838
82mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.10757838
83response to histamine (GO:0034776)3.10335415
84negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.08611525
85energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.06539647
86ATP hydrolysis coupled proton transport (GO:0015991)3.06539647
87neuronal action potential (GO:0019228)3.05775541
88regulation of synapse structural plasticity (GO:0051823)3.05184444
89behavioral response to cocaine (GO:0048148)3.04478915
90axoneme assembly (GO:0035082)3.04469212
91alanine transport (GO:0032328)3.04329457
92positive regulation of synapse maturation (GO:0090129)3.03448736
93kynurenine metabolic process (GO:0070189)3.03262812
94indolalkylamine metabolic process (GO:0006586)3.03032002
95regulation of synaptic transmission, glutamatergic (GO:0051966)3.02407139
96detection of light stimulus involved in sensory perception (GO:0050962)3.00030332
97detection of light stimulus involved in visual perception (GO:0050908)3.00030332
98long-term synaptic potentiation (GO:0060291)2.99569068
99positive regulation of synaptic transmission, GABAergic (GO:0032230)2.99313570
100long-term memory (GO:0007616)2.96098331
101G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.95770049
102respiratory chain complex IV assembly (GO:0008535)2.95493014
103membrane hyperpolarization (GO:0060081)2.95492682
104detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.94061776
105regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.93702948
106membrane depolarization during action potential (GO:0086010)2.93483873
107regulation of neurotransmitter transport (GO:0051588)2.93379785
108chaperone-mediated protein transport (GO:0072321)2.92213203
109neuromuscular process controlling posture (GO:0050884)2.91445998
110negative regulation of dendrite development (GO:2000171)2.91324465
111platelet dense granule organization (GO:0060155)2.91213879
112kidney morphogenesis (GO:0060993)2.89949442
113innervation (GO:0060384)2.89930685
114membrane depolarization (GO:0051899)2.89910549
115calcium ion-dependent exocytosis (GO:0017156)2.89890510
116synaptic transmission, cholinergic (GO:0007271)2.89276854
117protein localization to cilium (GO:0061512)2.89093240
118transferrin transport (GO:0033572)2.88942659
119regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.88860148
120detection of calcium ion (GO:0005513)2.88734272
121mitochondrial respiratory chain complex assembly (GO:0033108)2.88663910
122positive regulation of neurotransmitter transport (GO:0051590)2.88527493
123regulation of female receptivity (GO:0045924)2.88234734
124synaptic transmission (GO:0007268)2.87674413
125regulation of synaptic plasticity (GO:0048167)2.87544219
126cerebellar Purkinje cell differentiation (GO:0021702)2.87481254
127adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.86287338
128protein-cofactor linkage (GO:0018065)2.86250475
129synaptic vesicle transport (GO:0048489)2.85842762
130establishment of synaptic vesicle localization (GO:0097480)2.85842762
131regulation of microtubule-based movement (GO:0060632)2.85312022
132pyrimidine nucleobase catabolic process (GO:0006208)2.83568803
133mating behavior (GO:0007617)2.81678623
134cerebellar granule cell differentiation (GO:0021707)2.81618689
135mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.80480390
136regulation of synaptic transmission, GABAergic (GO:0032228)2.80442176
137positive regulation of neurotransmitter secretion (GO:0001956)2.77959327
138synapse organization (GO:0050808)2.77368050
139striatum development (GO:0021756)2.76662746
140learning (GO:0007612)2.76530167
141nephron epithelium morphogenesis (GO:0072088)2.76459522
142nephron tubule morphogenesis (GO:0072078)2.76459522
143regulation of glucokinase activity (GO:0033131)2.75322205
144regulation of hexokinase activity (GO:1903299)2.75322205
145somite rostral/caudal axis specification (GO:0032525)2.73886480
146protein K11-linked deubiquitination (GO:0035871)2.71404028
147nonmotile primary cilium assembly (GO:0035058)2.70948862
148neuromuscular synaptic transmission (GO:0007274)2.70376915
149cilium morphogenesis (GO:0060271)2.69916255
150cellular biogenic amine catabolic process (GO:0042402)2.66260449
151amine catabolic process (GO:0009310)2.66260449
152purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.66063101
1533-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.66063101
154spinal cord motor neuron differentiation (GO:0021522)2.64812618
155tryptophan metabolic process (GO:0006568)2.63860168
156negative regulation of mast cell activation (GO:0033004)2.62412203
157cilium movement (GO:0003341)2.62237915
158primary amino compound metabolic process (GO:1901160)2.62012140
159neural tube formation (GO:0001841)2.61649603
160sulfation (GO:0051923)2.60969005
161cilium organization (GO:0044782)2.60642927
162positive regulation of oligodendrocyte differentiation (GO:0048714)2.59689611
163cAMP catabolic process (GO:0006198)2.57971886
164retinal cone cell development (GO:0046549)2.57418327
165indole-containing compound metabolic process (GO:0042430)2.56559890
166cilium assembly (GO:0042384)2.56024179
167intraciliary transport (GO:0042073)2.55948210
168ubiquinone metabolic process (GO:0006743)2.55028144
169cytochrome complex assembly (GO:0017004)2.53669435
170GPI anchor metabolic process (GO:0006505)2.51426640
171rRNA catabolic process (GO:0016075)2.50427178
172regulation of respiratory system process (GO:0044065)2.49173172
173regulation of nuclear cell cycle DNA replication (GO:0033262)2.47325090
174positive regulation of action potential (GO:0045760)2.44892584
175adaptation of signaling pathway (GO:0023058)2.43681025
176ubiquinone biosynthetic process (GO:0006744)2.43220199
177piRNA metabolic process (GO:0034587)2.42564739
178auditory receptor cell stereocilium organization (GO:0060088)2.41626578
179regulation of rhodopsin mediated signaling pathway (GO:0022400)2.41490239
180arginine catabolic process (GO:0006527)2.39548673
181action potential (GO:0001508)2.39030592
182multicellular organism reproduction (GO:0032504)2.38255591
183positive regulation of meiosis (GO:0045836)2.37444169

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.89705883
2GBX2_23144817_ChIP-Seq_PC3_Human4.00723438
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.01035060
4JARID2_20064375_ChIP-Seq_MESCs_Mouse2.84240436
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.81140186
6REST_21632747_ChIP-Seq_MESCs_Mouse2.61661459
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.56644680
8TAF15_26573619_Chip-Seq_HEK293_Human2.51750817
9NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.51291420
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.48876820
11EZH2_18974828_ChIP-Seq_MESCs_Mouse2.46379273
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.46379273
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.45685597
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.39934348
15GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.38920790
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35475434
17EED_16625203_ChIP-ChIP_MESCs_Mouse2.31329589
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28740752
19CTBP2_25329375_ChIP-Seq_LNCAP_Human2.24814946
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.22989444
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.11573711
22SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08751226
23EZH2_27294783_Chip-Seq_ESCs_Mouse2.06727491
24ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03759334
25CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02362732
26HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.01546016
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.99552129
28BMI1_23680149_ChIP-Seq_NPCS_Mouse1.96512691
29RNF2_27304074_Chip-Seq_ESCs_Mouse1.95010555
30TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.91844012
31RARB_27405468_Chip-Seq_BRAIN_Mouse1.86568643
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.81043012
33P300_19829295_ChIP-Seq_ESCs_Human1.79699996
34DROSHA_22980978_ChIP-Seq_HELA_Human1.76006493
35SMAD4_21799915_ChIP-Seq_A2780_Human1.74283732
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.72945232
37TP53_22573176_ChIP-Seq_HFKS_Human1.68878097
38EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.68149674
39ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67677321
40AR_21572438_ChIP-Seq_LNCaP_Human1.64991983
41PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.64931701
42VDR_22108803_ChIP-Seq_LS180_Human1.55782129
43EWS_26573619_Chip-Seq_HEK293_Human1.55482641
44GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.54236660
45PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.52945545
46SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52085314
47POU3F2_20337985_ChIP-ChIP_501MEL_Human1.51724562
48RNF2_27304074_Chip-Seq_NSC_Mouse1.51575687
49ZNF274_21170338_ChIP-Seq_K562_Hela1.51527826
50IKZF1_21737484_ChIP-ChIP_HCT116_Human1.51475489
51TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50740911
52IGF1R_20145208_ChIP-Seq_DFB_Human1.47820762
53FUS_26573619_Chip-Seq_HEK293_Human1.43422425
54PCGF2_27294783_Chip-Seq_ESCs_Mouse1.43167464
55IRF1_19129219_ChIP-ChIP_H3396_Human1.40670946
56E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.40521683
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40521421
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39871710
59SMAD3_21741376_ChIP-Seq_EPCs_Human1.38261993
60OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37869712
61SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37547639
62ETV2_25802403_ChIP-Seq_MESCs_Mouse1.34629557
63MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.32795638
64RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.32672944
65PIAS1_25552417_ChIP-Seq_VCAP_Human1.31382480
66ER_23166858_ChIP-Seq_MCF-7_Human1.28778653
67GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.28305875
68NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27828764
69AR_25329375_ChIP-Seq_VCAP_Human1.27629086
70EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.27370545
71GATA3_21878914_ChIP-Seq_MCF-7_Human1.24613911
72UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.23790050
73SOX2_21211035_ChIP-Seq_LN229_Gbm1.23535999
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.22726779
75ERG_21242973_ChIP-ChIP_JURKAT_Human1.22347190
76GABP_17652178_ChIP-ChIP_JURKAT_Human1.20881846
77ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.20658935
78NANOG_19829295_ChIP-Seq_ESCs_Human1.17930070
79SOX2_19829295_ChIP-Seq_ESCs_Human1.17930070
80FOXA1_27270436_Chip-Seq_PROSTATE_Human1.17534348
81FOXA1_25329375_ChIP-Seq_VCAP_Human1.17534348
82STAT3_23295773_ChIP-Seq_U87_Human1.16156414
83TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.15231007
84MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14174089
85NCOR_22424771_ChIP-Seq_293T_Human1.12482690
86PCGF2_27294783_Chip-Seq_NPCs_Mouse1.11469181
87RING1B_27294783_Chip-Seq_ESCs_Mouse1.10290447
88ERA_21632823_ChIP-Seq_H3396_Human1.09667287
89MYC_19829295_ChIP-Seq_ESCs_Human1.09159801
90EST1_17652178_ChIP-ChIP_JURKAT_Human1.08871888
91TCF4_23295773_ChIP-Seq_U87_Human1.08629663
92TCF4_22108803_ChIP-Seq_LS180_Human1.08593625
93RUNX2_22187159_ChIP-Seq_PCA_Human1.08409293
94RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08058440
95MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07789665
96* JUN_21703547_ChIP-Seq_K562_Human1.07646861
97CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06647421
98RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05542704
99MYC_18940864_ChIP-ChIP_HL60_Human1.05457261
100KLF5_20875108_ChIP-Seq_MESCs_Mouse1.05416075
101AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.05283865
102TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.05255999
103FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.04911634
104PRDM14_20953172_ChIP-Seq_ESCs_Human1.02296939
105SMAD4_21741376_ChIP-Seq_EPCs_Human1.01809369
106HOXB7_26014856_ChIP-Seq_BT474_Human1.01575062
107AR_19668381_ChIP-Seq_PC3_Human1.00949236
108P53_22127205_ChIP-Seq_FIBROBLAST_Human1.00477707
109POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00372583
110TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00372583
111CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98434474
112SUZ12_27294783_Chip-Seq_NPCs_Mouse0.97856577
113NANOG_18555785_Chip-Seq_ESCs_Mouse0.97465469
114PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.97397864
115BCAT_22108803_ChIP-Seq_LS180_Human0.97126245
116NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96995925
117NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.96779011
118NFE2_27457419_Chip-Seq_LIVER_Mouse0.96743638
119TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96651392
120* TAF2_19829295_ChIP-Seq_ESCs_Human0.95846423
121FLI1_21867929_ChIP-Seq_TH2_Mouse0.95710933
122CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.95642452
123SOX9_26525672_Chip-Seq_HEART_Mouse0.94483153
124ARNT_22903824_ChIP-Seq_MCF-7_Human0.94339224
125KDM2B_26808549_Chip-Seq_REH_Human0.93091673
126* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.92865294
127RING1B_27294783_Chip-Seq_NPCs_Mouse0.91482218
128MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91213427
129YAP1_20516196_ChIP-Seq_MESCs_Mouse0.89594210
130MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.88708254
131RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88296659
132AHR_22903824_ChIP-Seq_MCF-7_Human0.87973357
133CBP_20019798_ChIP-Seq_JUKART_Human0.87724906
134IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87724906
135EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.86483462
136SMAD3_21741376_ChIP-Seq_ESCs_Human0.84137694
137EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.84129959

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.77786596
2MP0004859_abnormal_synaptic_plasticity4.64533143
3MP0003635_abnormal_synaptic_transmissio3.56166793
4MP0004270_analgesia3.43284906
5MP0001968_abnormal_touch/_nociception3.16249915
6MP0009745_abnormal_behavioral_response3.07474764
7MP0009046_muscle_twitch2.99196146
8MP0006276_abnormal_autonomic_nervous2.94109763
9MP0002063_abnormal_learning/memory/cond2.91709006
10MP0002064_seizures2.91617541
11MP0002735_abnormal_chemical_nociception2.88253633
12MP0002734_abnormal_mechanical_nocicepti2.73348679
13MP0003195_calcinosis2.73047835
14MP0002736_abnormal_nociception_after2.67270642
15MP0002572_abnormal_emotion/affect_behav2.62200258
16MP0005423_abnormal_somatic_nervous2.56011934
17MP0002272_abnormal_nervous_system2.55431461
18MP0000569_abnormal_digit_pigmentation2.40900758
19MP0002822_catalepsy2.35595737
20MP0008877_abnormal_DNA_methylation2.32766342
21MP0001486_abnormal_startle_reflex2.30771568
22MP0002733_abnormal_thermal_nociception2.17997227
23MP0000778_abnormal_nervous_system2.17756419
24MP0001440_abnormal_grooming_behavior2.13835405
25MP0001970_abnormal_pain_threshold2.06574960
26MP0002184_abnormal_innervation2.04609195
27MP0002067_abnormal_sensory_capabilities2.03435451
28MP0001529_abnormal_vocalization1.99232647
29MP0001501_abnormal_sleep_pattern1.92609672
30MP0001984_abnormal_olfaction1.86966377
31MP0003646_muscle_fatigue1.85568298
32MP0005646_abnormal_pituitary_gland1.77762254
33MP0003122_maternal_imprinting1.74344143
34MP0002557_abnormal_social/conspecific_i1.72813811
35MP0001905_abnormal_dopamine_level1.71754258
36MP0010386_abnormal_urinary_bladder1.69742079
37MP0008875_abnormal_xenobiotic_pharmacok1.68717906
38MP0004924_abnormal_behavior1.67780656
39MP0005386_behavior/neurological_phenoty1.67780656
40MP0004043_abnormal_pH_regulation1.67445204
41MP0003787_abnormal_imprinting1.65758093
42MP0004133_heterotaxia1.64029698
43MP0005084_abnormal_gallbladder_morpholo1.63280666
44MP0001188_hyperpigmentation1.56257994
45MP0005645_abnormal_hypothalamus_physiol1.54829501
46MP0004811_abnormal_neuron_physiology1.51845016
47MP0000955_abnormal_spinal_cord1.51632009
48MP0002882_abnormal_neuron_morphology1.44303132
49MP0004142_abnormal_muscle_tone1.43753067
50MP0002837_dystrophic_cardiac_calcinosis1.42977622
51MP0008569_lethality_at_weaning1.40778017
52MP0003011_delayed_dark_adaptation1.40315249
53MP0004858_abnormal_nervous_system1.38709137
54MP0003136_yellow_coat_color1.38648278
55MP0003879_abnormal_hair_cell1.37810012
56MP0002066_abnormal_motor_capabilities/c1.37427014
57MP0002653_abnormal_ependyma_morphology1.35897778
58MP0005551_abnormal_eye_electrophysiolog1.33279641
59MP0003329_amyloid_beta_deposits1.32466525
60MP0002928_abnormal_bile_duct1.31635601
61MP0001986_abnormal_taste_sensitivity1.30171294
62MP0009780_abnormal_chondrocyte_physiolo1.28859375
63MP0001502_abnormal_circadian_rhythm1.28662579
64MP0005174_abnormal_tail_pigmentation1.27063298
65MP0002938_white_spotting1.23054512
66MP0000372_irregular_coat_pigmentation1.21724415
67MP0000751_myopathy1.20110329
68MP0005394_taste/olfaction_phenotype1.14892537
69MP0005499_abnormal_olfactory_system1.14892537
70MP0002163_abnormal_gland_morphology1.13281961
71MP0003283_abnormal_digestive_organ1.13250439
72MP0002638_abnormal_pupillary_reflex1.11575373
73MP0005379_endocrine/exocrine_gland_phen1.10355801
74MP0002152_abnormal_brain_morphology1.10198883
75MP0002909_abnormal_adrenal_gland1.09942596
76MP0002229_neurodegeneration1.09757460
77MP0004742_abnormal_vestibular_system1.08658466
78MP0005365_abnormal_bile_salt1.05813618
79MP0000427_abnormal_hair_cycle1.02036738
80MP0002752_abnormal_somatic_nervous1.00974078
81MP0001963_abnormal_hearing_physiology0.98876579
82MP0008995_early_reproductive_senescence0.98355141
83MP0003633_abnormal_nervous_system0.96075761
84MP0000013_abnormal_adipose_tissue0.95407900
85MP0000631_abnormal_neuroendocrine_gland0.95108896
86MP0006072_abnormal_retinal_apoptosis0.95074717
87MP0002876_abnormal_thyroid_physiology0.94396587
88MP0010329_abnormal_lipoprotein_level0.93819627
89MP0002069_abnormal_eating/drinking_beha0.93814395
90MP0005410_abnormal_fertilization0.92934104
91MP0005167_abnormal_blood-brain_barrier0.90175331
92MP0003631_nervous_system_phenotype0.89585840
93MP0005377_hearing/vestibular/ear_phenot0.89147696
94MP0003878_abnormal_ear_physiology0.89147696
95MP0004085_abnormal_heartbeat0.88476569
96MP0005195_abnormal_posterior_eye0.88408342
97MP0004885_abnormal_endolymph0.86896590
98MP0002102_abnormal_ear_morphology0.86823866
99MP0008872_abnormal_physiological_respon0.86362832
100MP0002693_abnormal_pancreas_physiology0.85697428
101MP0002138_abnormal_hepatobiliary_system0.85171394
102MP0003634_abnormal_glial_cell0.83791378
103MP0008961_abnormal_basal_metabolism0.82751021
104MP0004147_increased_porphyrin_level0.81764949
105MP0005448_abnormal_energy_balance0.81436402
106MP0008789_abnormal_olfactory_epithelium0.81283450
107MP0003252_abnormal_bile_duct0.81077590
108MP0002751_abnormal_autonomic_nervous0.76664850
109MP0001919_abnormal_reproductive_system0.76428419
110MP0001324_abnormal_eye_pigmentation0.76050160
111MP0005332_abnormal_amino_acid0.75513953
112MP0000026_abnormal_inner_ear0.74983224
113MP0005535_abnormal_body_temperature0.73721448
114MP0004215_abnormal_myocardial_fiber0.72887287
115MP0004145_abnormal_muscle_electrophysio0.71834271
116MP0003121_genomic_imprinting0.71656733
117MP0001177_atelectasis0.71565200
118MP0006292_abnormal_olfactory_placode0.70953095
119MP0001664_abnormal_digestion0.69346639
120MP0008874_decreased_physiological_sensi0.68852042
121MP0005409_darkened_coat_color0.67486957
122MP0001485_abnormal_pinna_reflex0.66787570
123MP0005171_absent_coat_pigmentation0.66207211
124MP0005253_abnormal_eye_physiology0.66142171
125MP0003137_abnormal_impulse_conducting0.65881595
126MP0001943_abnormal_respiration0.64745917
127MP0003861_abnormal_nervous_system0.64214096
128MP0000538_abnormal_urinary_bladder0.63256451
129MP0003632_abnormal_nervous_system0.62054886
130MP0004484_altered_response_of0.58805823
131MP0006035_abnormal_mitochondrial_morpho0.56860371
132MP0004233_abnormal_muscle_weight0.56676503
133MP0000920_abnormal_myelination0.55352337
134MP0002090_abnormal_vision0.55047565
135MP0010770_preweaning_lethality0.53327078
136MP0002082_postnatal_lethality0.53327078

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.56247444
2Myokymia (HP:0002411)5.46770252
3Atonic seizures (HP:0010819)4.92389093
4Focal seizures (HP:0007359)4.87046889
5Epileptic encephalopathy (HP:0200134)4.62147564
6Febrile seizures (HP:0002373)4.51702120
7Pancreatic cysts (HP:0001737)4.42630641
8Visual hallucinations (HP:0002367)4.02173274
9Molar tooth sign on MRI (HP:0002419)3.98412371
10Abnormality of midbrain morphology (HP:0002418)3.98412371
11Absence seizures (HP:0002121)3.96006965
12Pancreatic fibrosis (HP:0100732)3.84957542
13Congenital stationary night blindness (HP:0007642)3.79954783
14Nephronophthisis (HP:0000090)3.72636800
15True hermaphroditism (HP:0010459)3.61277960
16Dialeptic seizures (HP:0011146)3.59538427
17Hyperventilation (HP:0002883)3.57496117
18Progressive cerebellar ataxia (HP:0002073)3.53955172
19Type II lissencephaly (HP:0007260)3.42556232
20Generalized tonic-clonic seizures (HP:0002069)3.40585116
21Limb dystonia (HP:0002451)3.30847346
22Gait imbalance (HP:0002141)3.28630879
23Pheochromocytoma (HP:0002666)3.19270109
24Abnormality of the renal cortex (HP:0011035)3.14688622
25Abnormality of the renal medulla (HP:0100957)3.08979368
26Polydipsia (HP:0001959)3.00877585
27Abnormal drinking behavior (HP:0030082)3.00877585
28Neuroendocrine neoplasm (HP:0100634)2.99718470
29Acute necrotizing encephalopathy (HP:0006965)2.98992515
30Amblyopia (HP:0000646)2.97595962
31Ankle clonus (HP:0011448)2.92876084
32Medial flaring of the eyebrow (HP:0010747)2.90940172
33Broad-based gait (HP:0002136)2.89952600
34Congenital primary aphakia (HP:0007707)2.88730700
35Truncal ataxia (HP:0002078)2.79876293
36Impaired vibration sensation in the lower limbs (HP:0002166)2.78198130
37Tubular atrophy (HP:0000092)2.77506622
38Attenuation of retinal blood vessels (HP:0007843)2.76499466
39Polyphagia (HP:0002591)2.75933433
40Lissencephaly (HP:0001339)2.75533836
41Abnormal mitochondria in muscle tissue (HP:0008316)2.73650638
42Progressive macrocephaly (HP:0004481)2.73393563
43Abnormal eating behavior (HP:0100738)2.70771744
44Progressive inability to walk (HP:0002505)2.70705971
45Cystic liver disease (HP:0006706)2.70306237
46Abnormality of the corticospinal tract (HP:0002492)2.69967070
47Nephrogenic diabetes insipidus (HP:0009806)2.68722912
48Gaze-evoked nystagmus (HP:0000640)2.67874637
49Abnormal hair whorl (HP:0010721)2.66802510
50Renal cortical cysts (HP:0000803)2.63767308
51Fetal akinesia sequence (HP:0001989)2.62787128
52Urinary bladder sphincter dysfunction (HP:0002839)2.61314223
53Excessive salivation (HP:0003781)2.56242578
54Drooling (HP:0002307)2.56242578
55Supranuclear gaze palsy (HP:0000605)2.55533840
56Failure to thrive in infancy (HP:0001531)2.55314307
57Genital tract atresia (HP:0001827)2.53248124
58Action tremor (HP:0002345)2.49729242
59Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.48168537
60Degeneration of the lateral corticospinal tracts (HP:0002314)2.48168537
61Vaginal atresia (HP:0000148)2.47743445
62Epileptiform EEG discharges (HP:0011182)2.47384395
63Chronic hepatic failure (HP:0100626)2.46129143
64Abolished electroretinogram (ERG) (HP:0000550)2.44740057
65Anxiety (HP:0000739)2.41964905
66Specific learning disability (HP:0001328)2.40451953
67EEG with generalized epileptiform discharges (HP:0011198)2.37681309
68Mitochondrial inheritance (HP:0001427)2.36465800
69Pachygyria (HP:0001302)2.35865903
70Hypothermia (HP:0002045)2.34735801
71Abnormal rod and cone electroretinograms (HP:0008323)2.33472254
72Inability to walk (HP:0002540)2.32855192
73Acute encephalopathy (HP:0006846)2.32565695
74Pendular nystagmus (HP:0012043)2.32081511
75Hepatocellular necrosis (HP:0001404)2.29372749
76Absent speech (HP:0001344)2.28515580
77Decreased central vision (HP:0007663)2.28469105
78Poor eye contact (HP:0000817)2.28320619
79Congenital hepatic fibrosis (HP:0002612)2.27242060
80Hepatic necrosis (HP:0002605)2.26666993
81Spastic gait (HP:0002064)2.26334168
82Polyuria (HP:0000103)2.26332102
83Dysdiadochokinesis (HP:0002075)2.26184186
84Absent/shortened dynein arms (HP:0200106)2.25169984
85Dynein arm defect of respiratory motile cilia (HP:0012255)2.25169984
86Hypsarrhythmia (HP:0002521)2.23826851
87Severe muscular hypotonia (HP:0006829)2.23515208
88Termporal pattern (HP:0011008)2.22371535
89Insidious onset (HP:0003587)2.22371535
90Poor suck (HP:0002033)2.22019277
91Decreased circulating renin level (HP:0003351)2.21658678
92Dysmetria (HP:0001310)2.17317955
93Esotropia (HP:0000565)2.15274141
94Concave nail (HP:0001598)2.13833669
95Mutism (HP:0002300)2.13443530
96Methylmalonic aciduria (HP:0012120)2.12864859
97Cerebellar dysplasia (HP:0007033)2.12486245
98Poor coordination (HP:0002370)2.11733854
99Large for gestational age (HP:0001520)2.11350618
100Abnormal ciliary motility (HP:0012262)2.10813239
101Methylmalonic acidemia (HP:0002912)2.10464845
102Delusions (HP:0000746)2.09827220
103Depression (HP:0000716)2.09601107
104Urinary urgency (HP:0000012)2.09523610
105Sclerocornea (HP:0000647)2.06617410
106Renal Fanconi syndrome (HP:0001994)2.06433415
107Impaired social interactions (HP:0000735)2.06373319
108Abnormal social behavior (HP:0012433)2.06373319
109Lipid accumulation in hepatocytes (HP:0006561)2.06329534
110Lower limb muscle weakness (HP:0007340)2.05973237
111Keratoconus (HP:0000563)2.04425505
112Increased corneal curvature (HP:0100692)2.04425505
113Anencephaly (HP:0002323)2.03853634
114Ketoacidosis (HP:0001993)2.01951224
115Scanning speech (HP:0002168)2.00945069
116Ketosis (HP:0001946)2.00146741
117Abnormality of glycolysis (HP:0004366)1.97975480
118Increased serum pyruvate (HP:0003542)1.97975480
119Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.97896547
120Abnormality of alanine metabolism (HP:0010916)1.97896547
121Hyperalaninemia (HP:0003348)1.97896547
122Furrowed tongue (HP:0000221)1.96810553
123Decreased electroretinogram (ERG) amplitude (HP:0000654)1.96784549
124Congenital, generalized hypertrichosis (HP:0004540)1.96465113
125Increased CSF lactate (HP:0002490)1.96161574
126Optic disc pallor (HP:0000543)1.95785348
127Abnormal respiratory motile cilium physiology (HP:0012261)1.95088226
128Bilateral microphthalmos (HP:0007633)1.94561733
129Focal dystonia (HP:0004373)1.92299147
1303-Methylglutaconic aciduria (HP:0003535)1.91844173
131Abnormality of the lower motor neuron (HP:0002366)1.91702699
132Torticollis (HP:0000473)1.91388051
133Genetic anticipation (HP:0003743)1.89906966
134Narrow nasal bridge (HP:0000446)1.89186217
135Hypoventilation (HP:0002791)1.88779685
136Progressive microcephaly (HP:0000253)1.88673517
137Blue irides (HP:0000635)1.87612448
138Aplasia/Hypoplasia of the brainstem (HP:0007362)1.86700737
139Hypoplasia of the brainstem (HP:0002365)1.86700737
140Hemiparesis (HP:0001269)1.86445763
141Abnormal respiratory motile cilium morphology (HP:0005938)1.85279373
142Abnormal respiratory epithelium morphology (HP:0012253)1.85279373
143Impaired vibratory sensation (HP:0002495)1.85174956
144Male pseudohermaphroditism (HP:0000037)1.85167680
145Bony spicule pigmentary retinopathy (HP:0007737)1.84895072
146Hyperthyroidism (HP:0000836)1.82898031
147Abnormal urine output (HP:0012590)1.82366391
148Retinal dysplasia (HP:0007973)1.81465764
149Agitation (HP:0000713)1.81099027
150Tachypnea (HP:0002789)1.80640946
151Sleep apnea (HP:0010535)1.80388306
152Occipital encephalocele (HP:0002085)1.79603018
153Abnormality of the labia minora (HP:0012880)1.79528742
154Abnormality of salivation (HP:0100755)1.79181154
155Psychosis (HP:0000709)1.78949448
156Postaxial foot polydactyly (HP:0001830)1.78627278
157Oligomenorrhea (HP:0000876)1.78134705
158Patellar aplasia (HP:0006443)1.77469423
159Cerebral inclusion bodies (HP:0100314)1.77184350
160Aplasia/Hypoplasia of the tongue (HP:0010295)1.76686899
161Disproportionate short-trunk short stature (HP:0003521)1.75131927
162Stomach cancer (HP:0012126)1.74678462
163Abnormal biliary tract physiology (HP:0012439)1.72651962
164Bile duct proliferation (HP:0001408)1.72651962

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.56774192
2CASK3.78038517
3NTRK33.72311682
4MARK13.35163267
5MAP3K43.28477372
6MAP2K73.23061303
7MAP3K122.79171365
8EPHA42.77683636
9MAP4K22.70976450
10PNCK2.61794691
11MINK12.50999490
12MAP3K92.48772235
13MAPK132.42686511
14ZAK2.39326429
15TAOK32.38006595
16DAPK22.12184403
17MAP2K42.05098450
18GRK12.02563626
19NTRK21.96022174
20INSRR1.87342840
21NUAK11.79143261
22PLK21.75137737
23GRK51.74453726
24PAK61.66122303
25ARAF1.63704100
26DAPK11.57017769
27PRPF4B1.56364950
28TLK11.52464291
29CDK191.51101350
30TNIK1.48913278
31NME11.43410960
32TXK1.40125365
33ACVR1B1.36218487
34UHMK11.35098537
35CDK51.32005975
36OXSR11.31855180
37NTRK11.30891006
38KSR11.28729461
39PRKCG1.22157911
40MAPKAPK51.20313026
41KSR21.18188514
42SGK2231.13868722
43SGK4941.13868722
44MAPKAPK31.12127337
45FGFR21.11923131
46CAMK2A1.10437440
47PRKD31.05040191
48BCR1.03860740
49PHKG11.02097100
50PHKG21.02097100
51CAMK2B0.98910648
52STK110.96717225
53CSNK1G20.93816862
54BCKDK0.93777532
55TIE10.93225169
56PDK40.91436893
57PDK30.91436893
58CDK140.91165507
59RIPK40.90940179
60WNK30.90747197
61GRK70.90445617
62CDK180.89706746
63TNK20.88113690
64LATS20.87500742
65TRIM280.87129688
66MAPK150.85978472
67SGK20.84479064
68CDK150.83077773
69AKT30.81266399
70DYRK20.80436365
71BMPR20.79518567
72PAK30.78400250
73PRKCE0.77503087
74SIK30.77184778
75CSNK1G30.77076787
76MAP2K60.75139572
77CDK11A0.74771988
78PRKCQ0.73491362
79MAP3K20.73067461
80STK38L0.73018169
81VRK10.72590850
82BMPR1B0.72030224
83ADRBK20.71547758
84CAMKK10.71425561
85CAMKK20.70548586
86PTK2B0.70525684
87DYRK1A0.69389225
88VRK20.68192630
89IKBKB0.67971424
90MKNK20.67140958
91STK390.66999455
92RPS6KA20.64785993
93FES0.64435984
94FLT30.64212553
95CAMK2D0.63538925
96LIMK10.62609677
97CAMK2G0.60344571
98SIK20.60134609
99BRAF0.59431681
100MAPK120.58677152
101ADRBK10.58254757
102EEF2K0.57060240
103FER0.56055616
104CCNB10.55406190
105GRK60.51440099
106TGFBR10.51287514
107ERBB30.50236081
108MUSK0.47965906
109WNK40.47962849
110PIK3CA0.47079881
111PRKCH0.46145968
112MAP2K10.45984392
113EPHA30.45962642
114ROCK20.45581989
115SYK0.45413120
116PINK10.45035850
117CSNK1A1L0.44945765
118PDK20.44497876
119ITK0.43558653
120CSNK1A10.43253033
121CAMK10.43078883
122PRKCZ0.42841965
123FGR0.42802480
124STK380.42777652
125PRKACA0.42549741
126TSSK60.42231852
127PRKG10.41827683
128OBSCN0.41620873
129DAPK30.41512696
130CSNK1D0.40982551
131CSNK1G10.40453023
132PRKCA0.40329911
133IKBKE0.39529988
134SGK10.39034948
135MYLK0.38720695
136RET0.38705980
137PKN10.38462879
138RAF10.38255104
139TESK10.37814855
140RPS6KA50.37758542
141PRKAA10.37194068
142TEC0.36287581
143KIT0.35238018
144PRKD20.34822477
145MAP4K10.33059133
146MAP3K110.32242087

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.98717803
2Synaptic vesicle cycle_Homo sapiens_hsa047213.76324330
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.80350061
4GABAergic synapse_Homo sapiens_hsa047272.77468428
5Collecting duct acid secretion_Homo sapiens_hsa049662.71714449
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.67036092
7Oxidative phosphorylation_Homo sapiens_hsa001902.58267203
8Morphine addiction_Homo sapiens_hsa050322.49613547
9Olfactory transduction_Homo sapiens_hsa047402.48887620
10Circadian entrainment_Homo sapiens_hsa047132.42244062
11Glutamatergic synapse_Homo sapiens_hsa047242.32540184
12Maturity onset diabetes of the young_Homo sapiens_hsa049502.30621466
13Nitrogen metabolism_Homo sapiens_hsa009102.30313164
14Amphetamine addiction_Homo sapiens_hsa050312.26980500
15Taste transduction_Homo sapiens_hsa047422.24860073
16Long-term potentiation_Homo sapiens_hsa047202.20727812
17Dopaminergic synapse_Homo sapiens_hsa047282.19129539
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.19038017
19Linoleic acid metabolism_Homo sapiens_hsa005912.14961968
20Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.05862419
21Parkinsons disease_Homo sapiens_hsa050122.02748111
22Serotonergic synapse_Homo sapiens_hsa047262.01424669
23Alzheimers disease_Homo sapiens_hsa050101.83398774
24Phototransduction_Homo sapiens_hsa047441.82529668
25Insulin secretion_Homo sapiens_hsa049111.80196589
26Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.79779248
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.79547676
28Salivary secretion_Homo sapiens_hsa049701.71891510
29Vibrio cholerae infection_Homo sapiens_hsa051101.68604739
30Cholinergic synapse_Homo sapiens_hsa047251.68210882
31Cardiac muscle contraction_Homo sapiens_hsa042601.66742679
32Ether lipid metabolism_Homo sapiens_hsa005651.58675009
33Long-term depression_Homo sapiens_hsa047301.58413435
34Tryptophan metabolism_Homo sapiens_hsa003801.56134534
35Cocaine addiction_Homo sapiens_hsa050301.56020410
36Renin secretion_Homo sapiens_hsa049241.51157016
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.47061724
38RNA polymerase_Homo sapiens_hsa030201.46220680
39Huntingtons disease_Homo sapiens_hsa050161.45935190
40Gastric acid secretion_Homo sapiens_hsa049711.42165602
41Selenocompound metabolism_Homo sapiens_hsa004501.40982261
42Propanoate metabolism_Homo sapiens_hsa006401.37703706
43Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37600126
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35561944
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.34186855
46Calcium signaling pathway_Homo sapiens_hsa040201.32394964
47Protein export_Homo sapiens_hsa030601.31408391
48Oxytocin signaling pathway_Homo sapiens_hsa049211.30970040
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.29238863
50ABC transporters_Homo sapiens_hsa020101.27635938
51Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.24580003
52Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.23899505
53Peroxisome_Homo sapiens_hsa041461.22957566
54Gap junction_Homo sapiens_hsa045401.20453329
55Intestinal immune network for IgA production_Homo sapiens_hsa046721.12702235
56Basal transcription factors_Homo sapiens_hsa030221.11870960
57Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.11353501
58Axon guidance_Homo sapiens_hsa043601.09912131
59GnRH signaling pathway_Homo sapiens_hsa049121.09294877
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.06262966
61Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.03906663
62Primary bile acid biosynthesis_Homo sapiens_hsa001200.98351545
63Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.91474951
64Butanoate metabolism_Homo sapiens_hsa006500.89505705
65Melanogenesis_Homo sapiens_hsa049160.86468876
66Primary immunodeficiency_Homo sapiens_hsa053400.85888963
67cAMP signaling pathway_Homo sapiens_hsa040240.85809154
68Arachidonic acid metabolism_Homo sapiens_hsa005900.84763285
69Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83906908
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.82149921
71Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81863277
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.81208242
73Sulfur relay system_Homo sapiens_hsa041220.80302747
74Caffeine metabolism_Homo sapiens_hsa002320.78590598
75Estrogen signaling pathway_Homo sapiens_hsa049150.77277063
76Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76999984
77ErbB signaling pathway_Homo sapiens_hsa040120.76878573
78Fanconi anemia pathway_Homo sapiens_hsa034600.76044964
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.75748141
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.73434706
81beta-Alanine metabolism_Homo sapiens_hsa004100.71625119
82cGMP-PKG signaling pathway_Homo sapiens_hsa040220.70973005
83RNA degradation_Homo sapiens_hsa030180.70640161
84Oocyte meiosis_Homo sapiens_hsa041140.70457952
85Pyruvate metabolism_Homo sapiens_hsa006200.69795898
86Vascular smooth muscle contraction_Homo sapiens_hsa042700.69673332
87Chemical carcinogenesis_Homo sapiens_hsa052040.68965069
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.64192775
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64124103
90Type II diabetes mellitus_Homo sapiens_hsa049300.62777671
91Homologous recombination_Homo sapiens_hsa034400.60583561
92One carbon pool by folate_Homo sapiens_hsa006700.60316257
93Fat digestion and absorption_Homo sapiens_hsa049750.59940259
94Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59847674
95Steroid biosynthesis_Homo sapiens_hsa001000.59727709
96Sulfur metabolism_Homo sapiens_hsa009200.59463405
97Glioma_Homo sapiens_hsa052140.58989072
98Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.58593576
99Rheumatoid arthritis_Homo sapiens_hsa053230.58372441
100Glycerolipid metabolism_Homo sapiens_hsa005610.58329110
101Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58049350
102Thyroid hormone synthesis_Homo sapiens_hsa049180.57307868
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57069880
104Metabolic pathways_Homo sapiens_hsa011000.55204876
105Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54796688
106Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53178574
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.52510279
108Alcoholism_Homo sapiens_hsa050340.50773437
109Retinol metabolism_Homo sapiens_hsa008300.49652964
110Dilated cardiomyopathy_Homo sapiens_hsa054140.48585958
111Ras signaling pathway_Homo sapiens_hsa040140.47501651
112Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47331474
113Glucagon signaling pathway_Homo sapiens_hsa049220.46686328
114MAPK signaling pathway_Homo sapiens_hsa040100.46522321
115Purine metabolism_Homo sapiens_hsa002300.46470708
116Pancreatic secretion_Homo sapiens_hsa049720.46447808
117Phagosome_Homo sapiens_hsa041450.45844066
118Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45667037
119Glycerophospholipid metabolism_Homo sapiens_hsa005640.45336686
120Regulation of autophagy_Homo sapiens_hsa041400.45104181
121Graft-versus-host disease_Homo sapiens_hsa053320.43570311
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.41545678
123Dorso-ventral axis formation_Homo sapiens_hsa043200.40855647
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39431953
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.38616556
126Choline metabolism in cancer_Homo sapiens_hsa052310.38519024
127Fatty acid elongation_Homo sapiens_hsa000620.37834288
128Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.37069197
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.36736557
130Asthma_Homo sapiens_hsa053100.35647851
131Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.35304345
132Prion diseases_Homo sapiens_hsa050200.33835509
133Ovarian steroidogenesis_Homo sapiens_hsa049130.33437980
134Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31508101
135Wnt signaling pathway_Homo sapiens_hsa043100.30842937
136Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30357526
137Inositol phosphate metabolism_Homo sapiens_hsa005620.27499668
138Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.26401625
139Circadian rhythm_Homo sapiens_hsa047100.25303405
140Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24526706
141Insulin signaling pathway_Homo sapiens_hsa049100.24281787
142Melanoma_Homo sapiens_hsa052180.23921976
143Rap1 signaling pathway_Homo sapiens_hsa040150.23622014
144Hedgehog signaling pathway_Homo sapiens_hsa043400.23450729
145Type I diabetes mellitus_Homo sapiens_hsa049400.23322910
146Sphingolipid signaling pathway_Homo sapiens_hsa040710.20929024
147Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20671838
148Bile secretion_Homo sapiens_hsa049760.19522184
149Neurotrophin signaling pathway_Homo sapiens_hsa047220.18597369
150Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.18010737

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