NID1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the nidogen family of basement membrane glycoproteins. The protein interacts with several other components of basement membranes, and may play a role in cell interactions with the extracellular matrix. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)6.01799637
2collagen fibril organization (GO:0030199)5.65298022
3retina vasculature morphogenesis in camera-type eye (GO:0061299)5.55119473
4chondrocyte proliferation (GO:0035988)5.02336183
5endodermal cell differentiation (GO:0035987)4.76494106
6bone trabecula formation (GO:0060346)4.57556593
7vascular endothelial growth factor signaling pathway (GO:0038084)4.51608163
8regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)4.48585718
9sequestering of extracellular ligand from receptor (GO:0035581)4.14001179
10collagen metabolic process (GO:0032963)4.05119300
11neuron projection extension involved in neuron projection guidance (GO:1902284)4.01539093
12axon extension involved in axon guidance (GO:0048846)4.01539093
13* basement membrane organization (GO:0071711)4.01374771
14negative regulation of fibrinolysis (GO:0051918)3.93664810
15collagen catabolic process (GO:0030574)3.92499753
16polarized epithelial cell differentiation (GO:0030859)3.90157753
17glomerular filtration (GO:0003094)3.86442400
18multicellular organismal macromolecule metabolic process (GO:0044259)3.85093786
19hippo signaling (GO:0035329)3.80941478
20peptidyl-glutamic acid carboxylation (GO:0017187)3.77039317
21protein carboxylation (GO:0018214)3.77039317
22renal filtration (GO:0097205)3.76649173
23cell adhesion mediated by integrin (GO:0033627)3.71820927
24multicellular organismal metabolic process (GO:0044236)3.67118108
25regulation of plasminogen activation (GO:0010755)3.66332654
26skin morphogenesis (GO:0043589)3.63835844
27positive regulation of endothelial cell apoptotic process (GO:2000353)3.63187126
28multicellular organismal catabolic process (GO:0044243)3.62678713
29substrate adhesion-dependent cell spreading (GO:0034446)3.59502384
30lymph vessel development (GO:0001945)3.59292116
31blood vessel maturation (GO:0001955)3.57174177
32negative regulation of chondrocyte differentiation (GO:0032331)3.55019267
33lymphangiogenesis (GO:0001946)3.53077715
34plasma membrane repair (GO:0001778)3.51750403
35* extracellular matrix disassembly (GO:0022617)3.49187618
36extracellular fibril organization (GO:0043206)3.44773111
37branching involved in salivary gland morphogenesis (GO:0060445)3.43789520
38cell migration involved in sprouting angiogenesis (GO:0002042)3.41847675
39regulation of fibrinolysis (GO:0051917)3.40946049
40mesenchymal-epithelial cell signaling (GO:0060638)3.39425936
41dermatan sulfate biosynthetic process (GO:0030208)3.36936458
42apoptotic cell clearance (GO:0043277)3.36225167
43cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.36034061
44wound healing, spreading of epidermal cells (GO:0035313)3.31515558
45insulin-like growth factor receptor signaling pathway (GO:0048009)3.31110986
46endothelial cell morphogenesis (GO:0001886)3.30746081
47negative regulation of cartilage development (GO:0061037)3.29093304
48regulation of protein activation cascade (GO:2000257)3.27095217
49endothelium development (GO:0003158)3.25815197
50regulation of complement activation (GO:0030449)3.25677741
51regulation of apoptotic cell clearance (GO:2000425)3.24673654
52negative regulation of catenin import into nucleus (GO:0035414)3.21369055
53endocardial cushion development (GO:0003197)3.21240397
54regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.16785365
55epithelial cell-cell adhesion (GO:0090136)3.16709034
56paraxial mesoderm development (GO:0048339)3.10664380
57positive regulation of extracellular matrix organization (GO:1903055)3.09854377
58negative regulation of fatty acid transport (GO:2000192)3.09725581
59regulation of extracellular matrix disassembly (GO:0010715)3.09673527
60protein localization to cell surface (GO:0034394)3.05899783
61fibril organization (GO:0097435)3.05128981
62trabecula formation (GO:0060343)3.04884782
63cellular response to vitamin (GO:0071295)3.02982792
64low-density lipoprotein particle clearance (GO:0034383)3.01685801
65dermatan sulfate metabolic process (GO:0030205)3.00959322
66positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.00401918
67negative regulation of smooth muscle cell migration (GO:0014912)2.99862201
68craniofacial suture morphogenesis (GO:0097094)2.96797702
69cell-substrate junction assembly (GO:0007044)2.95698354
70regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.94684914
71regulation of SMAD protein import into nucleus (GO:0060390)2.94594688
72stress fiber assembly (GO:0043149)2.91604915
73extracellular matrix assembly (GO:0085029)2.90640022
74positive regulation of epithelial to mesenchymal transition (GO:0010718)2.90544246
75blood vessel endothelial cell migration (GO:0043534)2.89538191
76cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.89423903
77hemidesmosome assembly (GO:0031581)2.87570019
78regulation of tight junction assembly (GO:2000810)2.87468140
79metanephric mesenchyme development (GO:0072075)2.87439328
80atrioventricular valve morphogenesis (GO:0003181)2.85638005
81* extracellular matrix organization (GO:0030198)2.83568834
82* extracellular structure organization (GO:0043062)2.82610508
83planar cell polarity pathway involved in neural tube closure (GO:0090179)2.81049410
84peptidyl-proline hydroxylation (GO:0019511)2.81048829
85cell proliferation involved in metanephros development (GO:0072203)2.80795429
86adherens junction assembly (GO:0034333)2.77738019
87focal adhesion assembly (GO:0048041)2.77338670
88cell-substrate adherens junction assembly (GO:0007045)2.77338670
89cardiac myofibril assembly (GO:0055003)2.75490997
90regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.75275400
91endothelial cell proliferation (GO:0001935)2.74095700
92kidney mesenchyme development (GO:0072074)2.73333315
93regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.73270655
94complement activation, alternative pathway (GO:0006957)2.72829824
95protein retention in ER lumen (GO:0006621)2.72647674
96establishment of apical/basal cell polarity (GO:0035089)2.72304382
97protein hydroxylation (GO:0018126)2.72072453
98maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.68720029
99regulation of cartilage development (GO:0061035)2.65980102
100cell migration involved in heart development (GO:0060973)2.65602373
101vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.63512514
102blood coagulation, intrinsic pathway (GO:0007597)2.63063629
103peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.62872785
104chondrocyte development (GO:0002063)2.62660937
105substrate-dependent cell migration (GO:0006929)2.60132934
106keratan sulfate catabolic process (GO:0042340)2.59416665
107regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.59222560
108tooth mineralization (GO:0034505)2.57960045
109venous blood vessel morphogenesis (GO:0048845)2.56420562
110positive regulation of collagen biosynthetic process (GO:0032967)2.56084566
111ovulation from ovarian follicle (GO:0001542)2.55842939
112blood vessel morphogenesis (GO:0048514)2.55773008
113Golgi transport vesicle coating (GO:0048200)2.54809470
114COPI coating of Golgi vesicle (GO:0048205)2.54809470
115regulation of chondrocyte differentiation (GO:0032330)2.54784481
116negative regulation of protein activation cascade (GO:2000258)2.53726468
117artery morphogenesis (GO:0048844)2.53054387
118regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.52862819
119regulation of cholesterol esterification (GO:0010872)2.52165553
120very-low-density lipoprotein particle assembly (GO:0034379)2.52122627
121positive regulation of blood vessel endothelial cell migration (GO:0043536)2.51976665
122positive regulation of osteoblast proliferation (GO:0033690)2.50690382
123* cell-substrate adhesion (GO:0031589)2.50478489
124patterning of blood vessels (GO:0001569)2.49591425
125low-density lipoprotein particle remodeling (GO:0034374)2.49036989
126regulation of endothelial cell apoptotic process (GO:2000351)2.49026676
127heart trabecula formation (GO:0060347)2.47403290
128wound healing, spreading of cells (GO:0044319)2.47247615
129positive regulation of fatty acid beta-oxidation (GO:0032000)2.45719709
130glial cell migration (GO:0008347)2.45081414
131positive regulation of glycogen biosynthetic process (GO:0045725)2.44870344
132mesodermal cell differentiation (GO:0048333)2.44149647
133smooth muscle tissue development (GO:0048745)2.43611672
134protein-lipid complex assembly (GO:0065005)2.43470470
135hyaluronan catabolic process (GO:0030214)2.43238747
136anatomical structure regression (GO:0060033)2.43160592
137cell proliferation involved in kidney development (GO:0072111)2.43034514
138pinocytosis (GO:0006907)2.42289977
139regulation of extracellular matrix organization (GO:1903053)2.42267053
140plasma lipoprotein particle assembly (GO:0034377)2.40746331

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.25414473
2TP63_17297297_ChIP-ChIP_HaCaT_Human5.16106791
3* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.95063982
4CLOCK_20551151_ChIP-Seq_293T_Human3.63279071
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.42672692
6ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.41521478
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.12454664
8PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.89022937
9ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.63164022
10* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.61681616
11RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.51032463
12CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.43294819
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.40588895
14TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.38734139
15THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.37004901
16* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.32412966
17* CJUN_26792858_Chip-Seq_BT549_Human2.28249765
18EP300_21415370_ChIP-Seq_HL-1_Mouse2.27599283
19EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.26648410
20WT1_19549856_ChIP-ChIP_CCG9911_Human2.20658546
21RXR_22158963_ChIP-Seq_LIVER_Mouse2.09508257
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.08763725
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.08499255
24* BRD4_25478319_ChIP-Seq_HGPS_Human2.07839750
25* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.97102522
26* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.93369507
27LXR_22158963_ChIP-Seq_LIVER_Mouse1.91797225
28* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.91171780
29ELK3_25401928_ChIP-Seq_HUVEC_Human1.86524571
30EGR1_19374776_ChIP-ChIP_THP-1_Human1.81441325
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.68332402
32ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.64231438
33NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.63731938
34NRF2_20460467_ChIP-Seq_MEFs_Mouse1.63731938
35RNF2_18974828_ChIP-Seq_MESCs_Mouse1.63514481
36EZH2_18974828_ChIP-Seq_MESCs_Mouse1.63514481
37HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.63271128
38STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62164592
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.61441240
40PPARA_22158963_ChIP-Seq_LIVER_Mouse1.61342658
41* FOXA2_19822575_ChIP-Seq_HepG2_Human1.60664968
42ESR2_21235772_ChIP-Seq_MCF-7_Human1.60548384
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.59907689
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.57133165
45ZNF263_19887448_ChIP-Seq_K562_Human1.55237902
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.53887453
47P300_27058665_Chip-Seq_ZR-75-30cells_Human1.52861183
48SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.52682661
49SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.52682661
50TBX20_22328084_ChIP-Seq_HEART_Mouse1.51652849
51TBX20_22080862_ChIP-Seq_HEART_Mouse1.51652849
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.50390038
53KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.45514997
54UBF1/2_26484160_Chip-Seq_HMECs_Human1.43100479
55FOXO3_23340844_ChIP-Seq_DLD1_Human1.42375316
56SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.41694466
57SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38470671
58SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.37284242
59TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.37211821
60TP53_16413492_ChIP-PET_HCT116_Human1.35644143
61SMAD_19615063_ChIP-ChIP_OVARY_Human1.34729195
62TP53_20018659_ChIP-ChIP_R1E_Mouse1.34005336
63ISL1_27105846_Chip-Seq_CPCs_Mouse1.32951692
64ZNF217_24962896_ChIP-Seq_MCF-7_Human1.32849876
65JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32759981
66SOX9_24532713_ChIP-Seq_HFSC_Mouse1.32597409
67SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.30204364
68KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.29140876
69KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.29140876
70KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.29140876
71SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.26945827
72TCF3_18692474_ChIP-Seq_MEFs_Mouse1.26199937
73JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.25875398
74* LXR_22292898_ChIP-Seq_THP-1_Human1.25414135
75POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24249590
76EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23554085
77SMC1_22415368_ChIP-Seq_MEFs_Mouse1.23320250
78CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.22202912
79KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22048448
80NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21130714
81SMC3_22415368_ChIP-Seq_MEFs_Mouse1.20772503
82ZFP281_18757296_ChIP-ChIP_E14_Mouse1.20689822
83MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.19807912
84TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.19405473
85* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.18920578
86FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.18035656
87ATF3_27146783_Chip-Seq_COLON_Human1.18007375
88DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.17929199
89* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.16474537
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.16363115
91PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16141020
92NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.13904000
93PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.13426627
94TP53_22127205_ChIP-Seq_IMR90_Human1.12741134
95SA1_22415368_ChIP-Seq_MEFs_Mouse1.12469574
96* SOX2_20726797_ChIP-Seq_SW620_Human1.12208012
97NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.12048375
98FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.08761652
99ESR1_20079471_ChIP-ChIP_T-47D_Human1.08221693
100RACK7_27058665_Chip-Seq_MCF-7_Human1.07650677
101* TP53_18474530_ChIP-ChIP_U2OS_Human1.06845912
102CTNNB1_20460455_ChIP-Seq_HCT116_Human1.06813851
103ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.06749663
104SALL1_21062744_ChIP-ChIP_HESCs_Human1.06699738
105BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.05594818
106ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03902028
107TP53_23651856_ChIP-Seq_MEFs_Mouse1.03352696
108AR_21909140_ChIP-Seq_LNCAP_Human1.03338637
109MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02551096
110* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse1.02321653
111WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01735522
112KDM2B_26808549_Chip-Seq_K562_Human1.01382514
113UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.99990150
114RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99813130
115EED_16625203_ChIP-ChIP_MESCs_Mouse0.98365099
116TCF4_18268006_ChIP-ChIP_LS174T_Human0.97929707
117KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.97351932
118EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96978364
119ESR1_15608294_ChIP-ChIP_MCF-7_Human0.96771282
120TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.95774180
121RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95325386
122TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.95076456
123FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.95048419
124SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.94746416
125SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.93084951
126FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.92907540
127JARID2_20075857_ChIP-Seq_MESCs_Mouse0.92230936
128NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.92126980

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.52251740
2MP0005275_abnormal_skin_tensile4.79799308
3MP0005503_abnormal_tendon_morphology4.61170812
4* MP0004272_abnormal_basement_membrane4.25791968
5MP0003705_abnormal_hypodermis_morpholog3.85105555
6MP0005623_abnormal_meninges_morphology3.12819783
7MP0003279_aneurysm3.00499620
8MP0010368_abnormal_lymphatic_system2.69474920
9MP0006054_spinal_hemorrhage2.60882897
10MP0001958_emphysema2.58460834
11MP0009384_cardiac_valve_regurgitation2.08616853
12MP0003566_abnormal_cell_adhesion2.07910588
13MP0005508_abnormal_skeleton_morphology1.87501877
14MP0001879_abnormal_lymphatic_vessel1.84815646
15MP0002108_abnormal_muscle_morphology1.84068811
16MP0000013_abnormal_adipose_tissue1.77797520
17MP0002060_abnormal_skin_morphology1.73671426
18MP0010352_gastrointestinal_tract_polyps1.62629113
19MP0000751_myopathy1.62601360
20MP0003091_abnormal_cell_migration1.58299862
21MP0005360_urolithiasis1.56960272
22MP0005023_abnormal_wound_healing1.54057020
23MP0003385_abnormal_body_wall1.50202399
24MP0005670_abnormal_white_adipose1.49811693
25MP0000733_abnormal_muscle_development1.49219610
26MP0005257_abnormal_intraocular_pressure1.47849000
27MP0002295_abnormal_pulmonary_circulatio1.45071695
28MP0010030_abnormal_orbit_morphology1.44011467
29MP0004858_abnormal_nervous_system1.42193570
30MP0000767_abnormal_smooth_muscle1.41699993
31MP0000003_abnormal_adipose_tissue1.34316968
32MP0009250_abnormal_appendicular_skeleto1.27221580
33MP0003283_abnormal_digestive_organ1.26999508
34MP0005409_darkened_coat_color1.26933816
35MP0003045_fibrosis1.25789549
36MP0000750_abnormal_muscle_regeneration1.24007181
37MP0004084_abnormal_cardiac_muscle1.23557720
38MP0009053_abnormal_anal_canal1.21506471
39MP0002896_abnormal_bone_mineralization1.20872049
40MP0001243_abnormal_dermal_layer1.20064254
41MP0009780_abnormal_chondrocyte_physiolo1.19054841
42MP0003941_abnormal_skin_development1.18817425
43MP0006138_congestive_heart_failure1.15591775
44MP0003828_pulmonary_edema1.14491790
45MP0003115_abnormal_respiratory_system1.14485969
46MP0000534_abnormal_ureter_morphology1.12217403
47MP0005076_abnormal_cell_differentiation1.12184746
48MP0005375_adipose_tissue_phenotype1.11296005
49MP0000428_abnormal_craniofacial_morphol1.09723870
50MP0003942_abnormal_urinary_system1.07895218
51MP0002933_joint_inflammation1.06403597
52MP0002168_other_aberrant_phenotype1.05881124
53MP0002128_abnormal_blood_circulation1.03235144
54MP0005666_abnormal_adipose_tissue1.02801999
55MP0001849_ear_inflammation1.02645779
56MP0003950_abnormal_plasma_membrane1.01382041
57MP0001915_intracranial_hemorrhage1.01365505
58MP0002282_abnormal_trachea_morphology1.00989991
59MP0002925_abnormal_cardiovascular_devel1.00302679
60MP0002932_abnormal_joint_morphology1.00235985
61MP0001299_abnormal_eye_distance/0.99470954
62MP0004087_abnormal_muscle_fiber0.98390093
63* MP0001614_abnormal_blood_vessel0.97426707
64MP0000163_abnormal_cartilage_morphology0.96636120
65MP0002139_abnormal_hepatobiliary_system0.96395170
66MP0003567_abnormal_fetal_cardiomyocyte0.96310428
67MP0002697_abnormal_eye_size0.96061675
68MP0002877_abnormal_melanocyte_morpholog0.95582431
69MP0004185_abnormal_adipocyte_glucose0.95130361
70MP0003122_maternal_imprinting0.93893753
71MP0010630_abnormal_cardiac_muscle0.92848386
72MP0001661_extended_life_span0.92392206
73MP0003868_abnormal_feces_composition0.91779844
74MP0005171_absent_coat_pigmentation0.90175536
75MP0000537_abnormal_urethra_morphology0.89708402
76MP0004134_abnormal_chest_morphology0.89566775
77MP0003935_abnormal_craniofacial_develop0.88797643
78MP0008775_abnormal_heart_ventricle0.88725617
79MP0002115_abnormal_skeleton_extremities0.86081930
80MP0005595_abnormal_vascular_smooth0.85680306
81MP0005390_skeleton_phenotype0.84843186
82MP0004130_abnormal_muscle_cell0.83793406
83MP0005058_abnormal_lysosome_morphology0.82889386
84MP0004197_abnormal_fetal_growth/weight/0.82235011
85MP0000749_muscle_degeneration0.80893081
86MP0003755_abnormal_palate_morphology0.80501069
87MP0001544_abnormal_cardiovascular_syste0.79954016
88MP0005385_cardiovascular_system_phenoty0.79954016
89MP0003300_gastrointestinal_ulcer0.79578369
90MP0004036_abnormal_muscle_relaxation0.79570769
91MP0000759_abnormal_skeletal_muscle0.79455187
92MP0005330_cardiomyopathy0.78779954
93MP0001542_abnormal_bone_strength0.78479089
94MP0000516_abnormal_urinary_system0.78221866
95MP0005367_renal/urinary_system_phenotyp0.78221866
96MP0005164_abnormal_response_to0.77238966
97MP0000266_abnormal_heart_morphology0.76875850
98MP0005365_abnormal_bile_salt0.76736151
99MP0005165_increased_susceptibility_to0.76140107
100MP0000432_abnormal_head_morphology0.74709170
101MP0004233_abnormal_muscle_weight0.74434783
102MP0002837_dystrophic_cardiac_calcinosis0.74187256
103MP0002113_abnormal_skeleton_development0.74144447
104MP0000762_abnormal_tongue_morphology0.73840921
105MP0000462_abnormal_digestive_system0.73361624
106MP0008004_abnormal_stomach_pH0.71948944
107MP0001175_abnormal_lung_morphology0.71646579
108MP0002086_abnormal_extraembryonic_tissu0.70533966
109MP0002088_abnormal_embryonic_growth/wei0.69660563
110MP0002127_abnormal_cardiovascular_syste0.69043641
111MP0009840_abnormal_foam_cell0.69029364
112MP0003984_embryonic_growth_retardation0.68646208
113MP0002089_abnormal_postnatal_growth/wei0.68627231
114MP0005197_abnormal_uvea_morphology0.68273892
115* MP0005369_muscle_phenotype0.68129910
116MP0002249_abnormal_larynx_morphology0.68097436
117MP0000049_abnormal_middle_ear0.67971849
118MP0002998_abnormal_bone_remodeling0.67503435
119MP0000249_abnormal_blood_vessel0.66001767
120MP0005620_abnormal_muscle_contractility0.65980918
121MP0010329_abnormal_lipoprotein_level0.65386542
122MP0002254_reproductive_system_inflammat0.60897432

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)7.84686233
2Premature rupture of membranes (HP:0001788)6.97347508
3Ankle contracture (HP:0006466)5.46099673
4Broad metatarsal (HP:0001783)5.14157974
5Shallow orbits (HP:0000586)4.88932642
6Aortic dissection (HP:0002647)4.55351245
7Cerebral aneurysm (HP:0004944)4.55164148
8Soft skin (HP:0000977)3.98811751
9Increased connective tissue (HP:0009025)3.87808425
10Atrophic scars (HP:0001075)3.76111910
11Cervical subluxation (HP:0003308)3.75971053
12Type 1 muscle fiber predominance (HP:0003803)3.72497300
13Aortic aneurysm (HP:0004942)3.68254581
14Bladder diverticulum (HP:0000015)3.67913567
15Spinal rigidity (HP:0003306)3.66949388
16Follicular hyperkeratosis (HP:0007502)3.64360654
17Deep venous thrombosis (HP:0002625)3.55327644
18Wrist flexion contracture (HP:0001239)3.38065431
19Dilatation of the ascending aorta (HP:0005111)3.34579496
20Fragile skin (HP:0001030)3.34366399
21Peritonitis (HP:0002586)3.32013443
22Mitral valve prolapse (HP:0001634)3.23865198
23Abnormality of dentin (HP:0010299)2.98889463
24Genu recurvatum (HP:0002816)2.98277110
25Blue sclerae (HP:0000592)2.97031783
26Increased variability in muscle fiber diameter (HP:0003557)2.95339802
27Wormian bones (HP:0002645)2.92781546
28Complement deficiency (HP:0004431)2.85417501
29Slender build (HP:0001533)2.79339564
30Abnormality of complement system (HP:0005339)2.71522603
31Neonatal short-limb short stature (HP:0008921)2.69727682
32Aneurysm (HP:0002617)2.65235284
33Short 4th metacarpal (HP:0010044)2.61991472
34Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.61991472
35Vertebral compression fractures (HP:0002953)2.60826028
36Hyperextensible skin (HP:0000974)2.58420833
37Mildly elevated creatine phosphokinase (HP:0008180)2.57842983
38Abnormality of skeletal muscle fiber size (HP:0012084)2.57604704
39Mitral stenosis (HP:0001718)2.45705499
40Overgrowth (HP:0001548)2.41534359
41Joint laxity (HP:0001388)2.38293197
42Biconcave vertebral bodies (HP:0004586)2.33820374
43Bowel diverticulosis (HP:0005222)2.32439605
44Muscle fiber splitting (HP:0003555)2.30515646
45Thin bony cortex (HP:0002753)2.29346352
46Wide anterior fontanel (HP:0000260)2.27813172
47Camptodactyly of toe (HP:0001836)2.25854889
48Lymphangioma (HP:0100764)2.24735512
49Abnormality of the 4th metacarpal (HP:0010012)2.23387368
50Abnormal delivery (HP:0001787)2.22304705
51Vascular tortuosity (HP:0004948)2.21975976
52Osteolytic defects of the phalanges of the hand (HP:0009771)2.21879478
53Osteolytic defects of the hand bones (HP:0009699)2.21879478
54Abnormality of the acetabulum (HP:0003170)2.21282643
55Round ear (HP:0100830)2.20150983
56Buphthalmos (HP:0000557)2.19254380
57Nonimmune hydrops fetalis (HP:0001790)2.18747929
58Elbow flexion contracture (HP:0002987)2.17326313
59Hemorrhage of the eye (HP:0011885)2.16013409
60Venous abnormality (HP:0002624)2.14074625
61Asymmetry of the thorax (HP:0001555)2.14035006
62Abnormality of carpal bone ossification (HP:0006257)2.12410156
63Striae distensae (HP:0001065)2.07995792
64Venous insufficiency (HP:0005293)2.07971424
65Deviation of the hallux (HP:0010051)2.01856909
66Broad ribs (HP:0000885)2.00392313
67Hypoplasia of the iris (HP:0007676)1.99796837
68Aortic regurgitation (HP:0001659)1.99583619
69Ectopia lentis (HP:0001083)1.99545152
70Coxa vara (HP:0002812)1.98322434
71Abnormal ossification of hand bones (HP:0005921)1.96279651
72Cupped ribs (HP:0000887)1.95723484
73Knee flexion contracture (HP:0006380)1.95247306
74Infantile muscular hypotonia (HP:0008947)1.94759713
75Coronal craniosynostosis (HP:0004440)1.94736552
76Mitral regurgitation (HP:0001653)1.94171469
77Hip contracture (HP:0003273)1.94039172
78Short hallux (HP:0010109)1.90132920
79Hallux valgus (HP:0001822)1.89046443
80Bell-shaped thorax (HP:0001591)1.87701307
81Joint hemorrhage (HP:0005261)1.86060682
82Hypoventilation (HP:0002791)1.85722913
83Arterial tortuosity (HP:0005116)1.85451760
84Hypoplastic ischia (HP:0003175)1.85312622
85Systemic lupus erythematosus (HP:0002725)1.85133466
86Cardiovascular calcification (HP:0011915)1.84942069
87Broad long bones (HP:0005622)1.84894663
88Scapular winging (HP:0003691)1.84739842
89Spinal cord lesions (HP:0100561)1.84320075
90Syringomyelia (HP:0003396)1.84320075
91Spondylolisthesis (HP:0003302)1.84111487
92Myocardial infarction (HP:0001658)1.84094019
93Abnormality of the peritoneum (HP:0002585)1.83031012
94Renal duplication (HP:0000075)1.82707050
95Limited hip movement (HP:0008800)1.82456980
96Mesomelia (HP:0003027)1.81992258
97Inguinal hernia (HP:0000023)1.81132436
98Aortic valve stenosis (HP:0001650)1.79670475
99Protruding ear (HP:0000411)1.79586822
100Enlarged penis (HP:0000040)1.79198908
101Generalized amyotrophy (HP:0003700)1.78636942
102Hyporeflexia of lower limbs (HP:0002600)1.77541203
103Rectal prolapse (HP:0002035)1.76351845
104Premature skin wrinkling (HP:0100678)1.76237933
105Joint contractures involving the joints of the feet (HP:0100492)1.76236687
106Flexion contracture of toe (HP:0005830)1.76236687
107Broad palm (HP:0001169)1.76203202
108Delayed closure of the anterior fontanelle (HP:0001476)1.75140860
109Mild short stature (HP:0003502)1.74941497
110Difficulty climbing stairs (HP:0003551)1.74786299
111Aplasia/Hypoplasia of the hallux (HP:0008362)1.74567248
112Pulmonary artery stenosis (HP:0004415)1.74487521
113Ovoid vertebral bodies (HP:0003300)1.74468604
114Right ventricular cardiomyopathy (HP:0011663)1.74074381
115Delayed cranial suture closure (HP:0000270)1.73853790
116Flared iliac wings (HP:0002869)1.72230943
117Abnormality of the ischium (HP:0003174)1.72144769
118Tibial bowing (HP:0002982)1.71196808
119Arachnodactyly (HP:0001166)1.71004759
120Disproportionate tall stature (HP:0001519)1.70766697
121Ulnar bowing (HP:0003031)1.70708295
122Short nail (HP:0001799)1.70403014
123Tarsal synostosis (HP:0008368)1.69853699
124Abnormality of the anterior chamber (HP:0000593)1.69547104
125Osteoarthritis (HP:0002758)1.68723166
126Breech presentation (HP:0001623)1.68646947
127Joint stiffness (HP:0001387)1.67476911
128Osteopenia (HP:0000938)1.67067031
129Prolonged partial thromboplastin time (HP:0003645)1.66256387
130Ulnar deviation of the wrist (HP:0003049)1.65246059
131Abnormal hand bone ossification (HP:0010660)1.65185469
132Skin nodule (HP:0200036)1.64071158

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR23.91171972
2TRIB33.83498622
3PDGFRA3.69856016
4TTN3.43933968
5LATS13.34773464
6KDR2.73960998
7SIK12.51244068
8TIE12.50704898
9LATS22.49650997
10PKN22.31210409
11EPHB22.30330490
12RIPK12.23294841
13TGFBR22.09564299
14ERN12.08691447
15PAK21.92361144
16CAMK1D1.85119686
17AKT31.81801828
18DMPK1.76403657
19FER1.68222793
20BMX1.63003806
21PTK21.60817822
22MET1.50298905
23STK31.48830302
24PTK61.48665750
25TGFBR11.46249973
26PTK2B1.45736046
27PDGFRB1.41443060
28CAMK1G1.32343126
29FGFR21.31782543
30CDK121.31227442
31PAK41.28628629
32LRRK21.26944268
33MTOR1.25689652
34SMG11.25201789
35FGFR11.23702357
36FRK1.20760312
37TRPM71.17098970
38PAK31.16974615
39EPHA21.15402498
40MYLK1.12128160
41NEK91.09423519
42PIK3CG1.02404901
43ROCK11.01185470
44EPHA30.96285786
45KIT0.92638487
46EEF2K0.92189071
47MOS0.92091255
48ERBB40.91223510
49PRKD30.90552331
50EPHB10.89969095
51ILK0.85453048
52PIK3CA0.84901238
53STK38L0.82324206
54MAPK70.81715685
55MAP3K100.81463825
56ICK0.80656829
57CDK60.80468838
58FGFR30.76558450
59MAP3K60.76178759
60MAP2K10.75173901
61PRKD20.74878028
62PRKD10.74652569
63RPS6KA40.73894305
64RPS6KA20.73749537
65TYRO30.72347567
66MAP3K70.71422007
67INSR0.66737813
68SCYL20.66674246
69LIMK10.65839985
70ROCK20.65596722
71STK380.65579277
72LMTK20.65139423
73STK100.64645452
74GSK3A0.62727880
75PDK20.62391567
76PRKG20.62351309
77FGFR40.61933702
78PDPK10.61099642
79IRAK30.60512516
80PRPF4B0.60506521
81RET0.60150220
82DYRK1B0.59411548
83NLK0.58522674
84PRKCH0.57073282
85WNK10.56546836
86KSR20.55649721
87CDC42BPA0.55498702
88MELK0.54568275
89ERBB30.53568416
90MARK20.53062905
91PDK40.52509406
92PDK30.52509406
93MAP3K30.52373076
94TESK10.50625780
95NUAK10.50065828
96MAPKAPK30.46528240
97PLK20.46514823
98FLT30.45217859
99SRC0.43321942
100IGF1R0.42874671
101JAK10.40802843
102CSK0.40186658
103MAPK110.39645802
104DAPK30.39642029
105TYK20.39183116
106PRKAA20.37322797
107PAK60.36120460
108MAP2K30.35953455
109NTRK10.35519093
110SGK30.35415729
111PIM20.35300320
112RPS6KC10.34622214
113RPS6KL10.34622214
114NEK10.34506867
115CDK90.33526372
116PAK10.33347217
117MAP3K80.32053962
118ZAP700.31851072
119MAP3K130.30587861
120* MAPK10.30391202
121WNK40.29920272
122MAPK120.28950504
123CDK40.27988235
124CDK70.26984743
125CHUK0.26899421
126ERBB20.26714743
127ABL20.26286684
128MAPKAPK20.25472724

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.89294672
2Focal adhesion_Homo sapiens_hsa045103.41507860
3Small cell lung cancer_Homo sapiens_hsa052222.72383302
4Protein digestion and absorption_Homo sapiens_hsa049742.61850270
5Adherens junction_Homo sapiens_hsa045202.51356154
6Amoebiasis_Homo sapiens_hsa051462.47099251
7Proteoglycans in cancer_Homo sapiens_hsa052052.38790930
8Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.23304631
9Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.12871633
10Dilated cardiomyopathy_Homo sapiens_hsa054142.08568318
11Glycosaminoglycan degradation_Homo sapiens_hsa005312.07754167
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.06843254
13Bacterial invasion of epithelial cells_Homo sapiens_hsa051002.01299610
14Hippo signaling pathway_Homo sapiens_hsa043901.87486780
15Basal cell carcinoma_Homo sapiens_hsa052171.86885880
16TGF-beta signaling pathway_Homo sapiens_hsa043501.85823771
17PI3K-Akt signaling pathway_Homo sapiens_hsa041511.85470120
18Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.79049118
19Bladder cancer_Homo sapiens_hsa052191.77873145
20Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.74757551
21MicroRNAs in cancer_Homo sapiens_hsa052061.74109580
22Viral myocarditis_Homo sapiens_hsa054161.70595906
23Hedgehog signaling pathway_Homo sapiens_hsa043401.61796156
24Other glycan degradation_Homo sapiens_hsa005111.43683157
25Pathways in cancer_Homo sapiens_hsa052001.38959486
26Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.38366425
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.37489795
28Melanoma_Homo sapiens_hsa052181.36811880
29Chronic myeloid leukemia_Homo sapiens_hsa052201.35879460
30Leukocyte transendothelial migration_Homo sapiens_hsa046701.33372701
31Regulation of actin cytoskeleton_Homo sapiens_hsa048101.32043082
32Tight junction_Homo sapiens_hsa045301.31660071
33Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.30818336
34Malaria_Homo sapiens_hsa051441.29190992
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.25431923
36Prostate cancer_Homo sapiens_hsa052151.24281489
37Toxoplasmosis_Homo sapiens_hsa051451.21561207
38PPAR signaling pathway_Homo sapiens_hsa033201.18670665
39Arginine biosynthesis_Homo sapiens_hsa002201.16624585
40p53 signaling pathway_Homo sapiens_hsa041151.13827455
41Rap1 signaling pathway_Homo sapiens_hsa040151.13008503
42AMPK signaling pathway_Homo sapiens_hsa041521.11006156
43Phenylalanine metabolism_Homo sapiens_hsa003601.09329832
44Fat digestion and absorption_Homo sapiens_hsa049751.07033322
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.04783533
46Central carbon metabolism in cancer_Homo sapiens_hsa052300.99175940
47Platelet activation_Homo sapiens_hsa046110.99054351
48Bile secretion_Homo sapiens_hsa049760.96870052
49Wnt signaling pathway_Homo sapiens_hsa043100.96665614
50Glioma_Homo sapiens_hsa052140.96211031
51Insulin resistance_Homo sapiens_hsa049310.94976612
52Notch signaling pathway_Homo sapiens_hsa043300.94932191
53Pancreatic cancer_Homo sapiens_hsa052120.94358931
54Lysine degradation_Homo sapiens_hsa003100.93988515
55Axon guidance_Homo sapiens_hsa043600.89527655
56Fatty acid biosynthesis_Homo sapiens_hsa000610.88084891
57Tyrosine metabolism_Homo sapiens_hsa003500.87277371
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.87164744
59Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86518269
60Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85955297
61Longevity regulating pathway - mammal_Homo sapiens_hsa042110.85529815
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.84025959
63HIF-1 signaling pathway_Homo sapiens_hsa040660.82767425
64HTLV-I infection_Homo sapiens_hsa051660.82465396
65Histidine metabolism_Homo sapiens_hsa003400.82080276
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80343727
67Endometrial cancer_Homo sapiens_hsa052130.79917230
68Renal cell carcinoma_Homo sapiens_hsa052110.79738899
69Colorectal cancer_Homo sapiens_hsa052100.79711262
70mTOR signaling pathway_Homo sapiens_hsa041500.78717674
71Thyroid cancer_Homo sapiens_hsa052160.78065719
72Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76772731
73Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76115517
74Pertussis_Homo sapiens_hsa051330.75539986
75Starch and sucrose metabolism_Homo sapiens_hsa005000.73782585
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.69857818
77Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.67857687
78Complement and coagulation cascades_Homo sapiens_hsa046100.67057137
79Shigellosis_Homo sapiens_hsa051310.65892648
80Fatty acid metabolism_Homo sapiens_hsa012120.64239780
81Insulin signaling pathway_Homo sapiens_hsa049100.64147997
82Melanogenesis_Homo sapiens_hsa049160.62740430
83Galactose metabolism_Homo sapiens_hsa000520.62269925
84Staphylococcus aureus infection_Homo sapiens_hsa051500.62037981
85N-Glycan biosynthesis_Homo sapiens_hsa005100.61946993
86Renin-angiotensin system_Homo sapiens_hsa046140.61597507
87Estrogen signaling pathway_Homo sapiens_hsa049150.60907193
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60303124
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59250961
90Ras signaling pathway_Homo sapiens_hsa040140.58112104
91Ovarian steroidogenesis_Homo sapiens_hsa049130.57182125
92Primary bile acid biosynthesis_Homo sapiens_hsa001200.56307856
93Vitamin digestion and absorption_Homo sapiens_hsa049770.56170445
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.55454708
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55255398
96FoxO signaling pathway_Homo sapiens_hsa040680.54932211
97Vascular smooth muscle contraction_Homo sapiens_hsa042700.54536250
98Viral carcinogenesis_Homo sapiens_hsa052030.54485928
99Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.53293924
100Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.53167090
101Gap junction_Homo sapiens_hsa045400.51939561
102TNF signaling pathway_Homo sapiens_hsa046680.50742551
103Endocytosis_Homo sapiens_hsa041440.49330613
104VEGF signaling pathway_Homo sapiens_hsa043700.49313850
105Dorso-ventral axis formation_Homo sapiens_hsa043200.48863055
106Choline metabolism in cancer_Homo sapiens_hsa052310.48778074
107Biosynthesis of amino acids_Homo sapiens_hsa012300.48037951
108Arginine and proline metabolism_Homo sapiens_hsa003300.47622323
109Retinol metabolism_Homo sapiens_hsa008300.47390020
110Steroid hormone biosynthesis_Homo sapiens_hsa001400.47296251
111Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.47073036
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46411951
113Nitrogen metabolism_Homo sapiens_hsa009100.46098652
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.45728124
115Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.45682943
116GnRH signaling pathway_Homo sapiens_hsa049120.45063267
117Prion diseases_Homo sapiens_hsa050200.43117136
118Hepatitis B_Homo sapiens_hsa051610.42248093
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.41291037
120Acute myeloid leukemia_Homo sapiens_hsa052210.41147783
121Glucagon signaling pathway_Homo sapiens_hsa049220.39348205
122Thyroid hormone synthesis_Homo sapiens_hsa049180.38798526
123Cell cycle_Homo sapiens_hsa041100.35366973
124Fatty acid degradation_Homo sapiens_hsa000710.34434147
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34368902
126Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.33358699
127Propanoate metabolism_Homo sapiens_hsa006400.33057771
128Salmonella infection_Homo sapiens_hsa051320.31122596
129Apoptosis_Homo sapiens_hsa042100.30661091
130MAPK signaling pathway_Homo sapiens_hsa040100.27383713
131Non-small cell lung cancer_Homo sapiens_hsa052230.26962357

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