NIF3L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polyketide metabolic process (GO:0030638)7.52116515
2doxorubicin metabolic process (GO:0044598)7.52116515
3daunorubicin metabolic process (GO:0044597)7.52116515
4regulation of nuclear cell cycle DNA replication (GO:0033262)5.83076381
5rRNA modification (GO:0000154)5.02061238
6DNA replication checkpoint (GO:0000076)4.96201980
7rRNA methylation (GO:0031167)4.93657477
8protein localization to kinetochore (GO:0034501)4.90547326
9regulation of telomere maintenance via telomerase (GO:0032210)4.85759265
10cullin deneddylation (GO:0010388)4.69745017
11aminoglycoside antibiotic metabolic process (GO:0030647)4.66315541
12establishment of integrated proviral latency (GO:0075713)4.52436973
13rRNA transcription (GO:0009303)4.34822836
14negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.32008791
15protein deneddylation (GO:0000338)4.28230884
16regulation of mammary gland epithelial cell proliferation (GO:0033599)4.17546486
17negative regulation of telomere maintenance (GO:0032205)4.15762045
18ribosomal small subunit biogenesis (GO:0042274)4.12193639
19DNA damage response, detection of DNA damage (GO:0042769)4.11844926
20negative regulation of telomerase activity (GO:0051974)4.09543443
21ribosome biogenesis (GO:0042254)4.08931683
22metaphase plate congression (GO:0051310)4.08404662
23maintenance of protein location in nucleus (GO:0051457)4.05109469
24negative regulation of epidermis development (GO:0045683)4.04702383
25negative regulation of cell cycle G2/M phase transition (GO:1902750)4.00865444
26histone exchange (GO:0043486)3.98845889
27pseudouridine synthesis (GO:0001522)3.96176682
28negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.89858203
29DNA replication initiation (GO:0006270)3.86853676
30purine nucleobase biosynthetic process (GO:0009113)3.85508805
31DNA replication-independent nucleosome assembly (GO:0006336)3.83993200
32mitotic sister chromatid segregation (GO:0000070)3.83146685
33regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.82175842
34ribonucleoprotein complex biogenesis (GO:0022613)3.81657634
35protein localization to chromosome, centromeric region (GO:0071459)3.81217908
36histone H4-K5 acetylation (GO:0043981)3.79154697
37histone H4-K8 acetylation (GO:0043982)3.79154697
38anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.78401524
39histone H4-K12 acetylation (GO:0043983)3.77909243
40IMP biosynthetic process (GO:0006188)3.74772256
41DNA replication-dependent nucleosome organization (GO:0034723)3.74323186
42DNA replication-dependent nucleosome assembly (GO:0006335)3.74323186
43DNA ligation (GO:0006266)3.74095547
44somite rostral/caudal axis specification (GO:0032525)3.72997302
45positive regulation of DNA-dependent DNA replication (GO:2000105)3.69560860
46regulation of cilium movement (GO:0003352)3.68221523
47formation of translation preinitiation complex (GO:0001731)3.62097107
48ribosome assembly (GO:0042255)3.61866758
49muscle organ morphogenesis (GO:0048644)3.61825812
50establishment of protein localization to mitochondrial membrane (GO:0090151)3.61356340
51positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.58493914
52spindle checkpoint (GO:0031577)3.57411545
53negative regulation of sister chromatid segregation (GO:0033046)3.56170038
54negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.56170038
55negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.56170038
56negative regulation of mitotic sister chromatid segregation (GO:0033048)3.56170038
57negative regulation of mitotic sister chromatid separation (GO:2000816)3.56170038
58negative regulation of chromosome segregation (GO:0051985)3.55229792
59negative regulation of ligase activity (GO:0051352)3.52981277
60negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.52981277
61mitotic spindle checkpoint (GO:0071174)3.48026862
62regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.47421441
63chaperone-mediated protein transport (GO:0072321)3.46357511
64regulation of mitochondrial translation (GO:0070129)3.46183341
65regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.45314628
66regulation of mitotic spindle checkpoint (GO:1903504)3.45314628
67quinone metabolic process (GO:1901661)3.45271778
68L-serine metabolic process (GO:0006563)3.44913868
69establishment of viral latency (GO:0019043)3.44587031
70non-recombinational repair (GO:0000726)3.41131767
71double-strand break repair via nonhomologous end joining (GO:0006303)3.41131767
72mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.40725694
73negative regulation of epidermal cell differentiation (GO:0045605)3.39029149
74regulation of response to osmotic stress (GO:0047484)3.36914717
75regulation of translation in response to stress (GO:0043555)3.36802956
76establishment of chromosome localization (GO:0051303)3.35272039
77transcription from RNA polymerase I promoter (GO:0006360)3.32788155
78mitotic chromosome condensation (GO:0007076)3.31105883
79regulation of chromosome segregation (GO:0051983)3.30589514
80cellular component biogenesis (GO:0044085)3.30071472
81mitotic spindle assembly checkpoint (GO:0007094)3.29132000
82regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.28731137
83regulation of mitotic metaphase/anaphase transition (GO:0030071)3.28731137
84negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.28185948
85proteasome assembly (GO:0043248)3.28099691
86spindle assembly checkpoint (GO:0071173)3.23324300
87regulation of double-strand break repair via homologous recombination (GO:0010569)3.22143400
88regulation of MHC class I biosynthetic process (GO:0045343)3.22116358
89IMP metabolic process (GO:0046040)3.22010661
90mitotic nuclear envelope disassembly (GO:0007077)3.20693003
91DNA double-strand break processing (GO:0000729)3.20691200
92telomere maintenance via semi-conservative replication (GO:0032201)3.20147845
93regulation of mitotic sister chromatid separation (GO:0010965)3.19905748
94regulation of mitotic sister chromatid segregation (GO:0033047)3.19905748
95regulation of sister chromatid segregation (GO:0033045)3.19905748
96regulation of centriole replication (GO:0046599)3.17738623
97regulation of telomere maintenance (GO:0032204)3.17660649
98DNA catabolic process, exonucleolytic (GO:0000738)3.16761809
99nucleotide-excision repair, DNA gap filling (GO:0006297)3.16151982
100protein K6-linked ubiquitination (GO:0085020)3.15600999
101mitochondrial DNA replication (GO:0006264)3.13772694
102nuclear pore complex assembly (GO:0051292)3.12450280
103transcription elongation from RNA polymerase III promoter (GO:0006385)3.11169734
104termination of RNA polymerase III transcription (GO:0006386)3.11169734
105regulation of spindle organization (GO:0090224)3.10737276
106DNA strand elongation involved in DNA replication (GO:0006271)3.10162409
107positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.08888950
108sister chromatid segregation (GO:0000819)3.06858065
109interferon-gamma production (GO:0032609)3.06574487
110spliceosomal complex assembly (GO:0000245)3.05071778
111GDP-mannose metabolic process (GO:0019673)3.04038310
112notochord development (GO:0030903)3.02096334
113nuclear pore organization (GO:0006999)3.01778182
114rRNA processing (GO:0006364)3.01412062
115DNA strand elongation (GO:0022616)3.00814856
116negative regulation of mitosis (GO:0045839)2.99970758
117CENP-A containing nucleosome assembly (GO:0034080)2.99802087
118maturation of SSU-rRNA (GO:0030490)2.99124140
119mitotic sister chromatid cohesion (GO:0007064)2.97956840
120somatic hypermutation of immunoglobulin genes (GO:0016446)2.95954863
121somatic diversification of immune receptors via somatic mutation (GO:0002566)2.95954863
122regulation of telomerase activity (GO:0051972)2.95803966
123positive regulation of ligase activity (GO:0051351)2.95614481
124negative regulation of DNA-dependent DNA replication (GO:2000104)2.95205224
125nuclear envelope disassembly (GO:0051081)2.94836498
126membrane disassembly (GO:0030397)2.94836498
127regulation of ubiquitin-protein transferase activity (GO:0051438)2.93923585
128DNA unwinding involved in DNA replication (GO:0006268)2.92800483
129chromatin remodeling at centromere (GO:0031055)2.92459880
130cell cycle G1/S phase transition (GO:0044843)2.92254484
131G1/S transition of mitotic cell cycle (GO:0000082)2.92254484
132ribosomal large subunit biogenesis (GO:0042273)2.92198673
133mitotic recombination (GO:0006312)2.92190422
134negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.91037045
135spliceosomal snRNP assembly (GO:0000387)2.90982751
136rRNA metabolic process (GO:0016072)2.89864507
137exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.89668237
138mitotic metaphase plate congression (GO:0007080)2.89505857
139telomere maintenance via recombination (GO:0000722)2.89266824
140signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.86358212
141transcription from mitochondrial promoter (GO:0006390)2.85584866
142nucleoside transmembrane transport (GO:1901642)2.84084103
143regulation of apoptotic process involved in morphogenesis (GO:1902337)2.81250956
144kinetochore assembly (GO:0051382)2.80815419
145DNA deamination (GO:0045006)2.80043461
146nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.78697796
147regulation of DNA-dependent DNA replication (GO:0090329)2.76135162
148termination of RNA polymerase I transcription (GO:0006363)2.74508264
149attachment of spindle microtubules to kinetochore (GO:0008608)2.73543979
1507-methylguanosine mRNA capping (GO:0006370)2.70782867
151transcription elongation from RNA polymerase I promoter (GO:0006362)2.70526228
152RNA capping (GO:0036260)2.70035433
1537-methylguanosine RNA capping (GO:0009452)2.70035433
154telomere maintenance via telomere lengthening (GO:0010833)2.66879315
155maturation of 5.8S rRNA (GO:0000460)2.66337475
156regulation of double-strand break repair (GO:2000779)2.66186938
157nucleobase biosynthetic process (GO:0046112)2.65977184
158mitotic G2/M transition checkpoint (GO:0044818)2.63614619
159kinetochore organization (GO:0051383)2.63346928
160chromatin assembly (GO:0031497)2.63296434
161heterochromatin organization (GO:0070828)2.62997976
162ribosomal small subunit assembly (GO:0000028)2.62690592
163DNA duplex unwinding (GO:0032508)2.62037733
164DNA replication-independent nucleosome organization (GO:0034724)2.61831252

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.23820233
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.85241894
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.01977093
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.01977093
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.01977093
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.95602446
7BP1_19119308_ChIP-ChIP_Hs578T_Human3.90826801
8MYC_18555785_ChIP-Seq_MESCs_Mouse3.66604675
9* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.50914118
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.22131006
11TP63_19390658_ChIP-ChIP_HaCaT_Human3.05670080
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.92793078
13* GABP_17652178_ChIP-ChIP_JURKAT_Human2.90512341
14* CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.77657046
15* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.65122516
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.61859968
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.57431647
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.57415470
19* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.55754903
20ETS1_20019798_ChIP-Seq_JURKAT_Human2.48219921
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.41610856
22YY1_21170310_ChIP-Seq_MESCs_Mouse2.31262355
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30094873
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.22745525
25EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.19588426
26NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.16190247
27IRF1_19129219_ChIP-ChIP_H3396_Human2.11016099
28FOXM1_23109430_ChIP-Seq_U2OS_Human2.07635937
29MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.05481493
30* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse2.00156960
31VDR_23849224_ChIP-Seq_CD4+_Human1.99468094
32* FOXP3_21729870_ChIP-Seq_TREG_Human1.99424502
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.96467730
34TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.87391011
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86458225
36SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.85165481
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83208822
38NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81813965
39NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.81437241
40ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.77462793
41* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.76618582
42POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.75855478
43XRN2_22483619_ChIP-Seq_HELA_Human1.75386010
44NOTCH1_21737748_ChIP-Seq_TLL_Human1.73873952
45NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73813443
46SOX2_18555785_ChIP-Seq_MESCs_Mouse1.70006577
47RBPJ_22232070_ChIP-Seq_NCS_Mouse1.67975776
48THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64998321
49DCP1A_22483619_ChIP-Seq_HELA_Human1.64161029
50MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.63543224
51* TTF2_22483619_ChIP-Seq_HELA_Human1.61557057
52PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58432659
53* TCF3_18692474_ChIP-Seq_MESCs_Mouse1.58406742
54HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58190766
55SRF_21415370_ChIP-Seq_HL-1_Mouse1.56290568
56* ELK1_19687146_ChIP-ChIP_HELA_Human1.55371505
57YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52532279
58GABP_19822575_ChIP-Seq_HepG2_Human1.50238809
59* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.49875240
60KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.47205343
61POU5F1_16153702_ChIP-ChIP_HESCs_Human1.46225041
62SALL1_21062744_ChIP-ChIP_HESCs_Human1.43265199
63NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.36903450
64MYCN_18555785_ChIP-Seq_MESCs_Mouse1.35813872
65PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.34167817
66ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.29590468
67CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.26995118
68KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25109866
69SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22475009
70DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21569984
71* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21194314
72HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.21125569
73RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18420585
74* NANOG_16153702_ChIP-ChIP_HESCs_Human1.15436439
75E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.15241241
76HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13343787
77FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12920857
78STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11858841
79EWS_26573619_Chip-Seq_HEK293_Human1.11575162
80* ELK1_22589737_ChIP-Seq_MCF10A_Human1.06397544
81PADI4_21655091_ChIP-ChIP_MCF-7_Human1.06008152
82POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.05436775
83MYC_18940864_ChIP-ChIP_HL60_Human1.04861193
84CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.04846420
85CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.02001124
86SOX17_20123909_ChIP-Seq_XEN_Mouse1.01827023
87KDM5A_27292631_Chip-Seq_BREAST_Human1.00638557
88CIITA_25753668_ChIP-Seq_RAJI_Human1.00289758
89SOX2_16153702_ChIP-ChIP_HESCs_Human0.99936958
90* KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99701279
91CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.99534003
92E2F1_21310950_ChIP-Seq_MCF-7_Human0.98426923
93ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.98300164
94NANOG_18692474_ChIP-Seq_MEFs_Mouse0.97017070
95FUS_26573619_Chip-Seq_HEK293_Human0.96656944
96ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96072598
97ZNF274_21170338_ChIP-Seq_K562_Hela0.95826983
98NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.94478991
99POU5F1_16518401_ChIP-PET_MESCs_Mouse0.94220487
100ERG_20887958_ChIP-Seq_HPC-7_Mouse0.94038446
101AR_21909140_ChIP-Seq_LNCAP_Human0.93810142
102FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93069880
103SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91903083
104OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90937192
105E2F1_17053090_ChIP-ChIP_MCF-7_Human0.90700734
106SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.90176982
107* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.89859398
108E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.88434957
109TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.88240963
110SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.87584715
111NANOG_18692474_ChIP-Seq_MESCs_Mouse0.87059329
112SOX2_18692474_ChIP-Seq_MESCs_Mouse0.86869963
113SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85067235
114NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.84368795
115BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84326713
116TFEB_21752829_ChIP-Seq_HELA_Human0.82463732
117CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.79637398
118VDR_22108803_ChIP-Seq_LS180_Human0.74932677
119HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.73640667
120* FLI1_27457419_Chip-Seq_LIVER_Mouse0.73063913
121TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.72560713
122CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.72115300
123KLF4_18555785_ChIP-Seq_MESCs_Mouse0.68898807
124* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.68133632
125ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.63915207

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode5.10430475
2MP0008057_abnormal_DNA_replication3.89707543
3MP0003011_delayed_dark_adaptation3.43082851
4MP0004957_abnormal_blastocyst_morpholog3.29625609
5MP0005394_taste/olfaction_phenotype3.09545718
6MP0005499_abnormal_olfactory_system3.09545718
7MP0005075_abnormal_melanosome_morpholog3.02214910
8MP0003890_abnormal_embryonic-extraembry2.94810305
9MP0003693_abnormal_embryo_hatching2.65190347
10MP0003111_abnormal_nucleus_morphology2.64132984
11MP0010094_abnormal_chromosome_stability2.61289441
12MP0008058_abnormal_DNA_repair2.56318148
13MP0003077_abnormal_cell_cycle2.43592949
14MP0008789_abnormal_olfactory_epithelium2.13804956
15MP0003121_genomic_imprinting2.13082021
16MP0004264_abnormal_extraembryonic_tissu2.12569185
17MP0003122_maternal_imprinting2.03661250
18MP0002254_reproductive_system_inflammat2.01644590
19MP0009697_abnormal_copulation1.98537934
20MP0008007_abnormal_cellular_replicative1.96191168
21MP0002277_abnormal_respiratory_mucosa1.94781201
22MP0003786_premature_aging1.93340857
23MP0008932_abnormal_embryonic_tissue1.90674570
24MP0010030_abnormal_orbit_morphology1.79953806
25MP0002332_abnormal_exercise_endurance1.77234266
26MP0006035_abnormal_mitochondrial_morpho1.77018399
27MP0003806_abnormal_nucleotide_metabolis1.76661943
28MP0003938_abnormal_ear_development1.73402512
29MP0000049_abnormal_middle_ear1.63582147
30MP0003123_paternal_imprinting1.60738187
31MP0000678_abnormal_parathyroid_gland1.60343397
32MP0004381_abnormal_hair_follicle1.59176163
33MP0001293_anophthalmia1.56654170
34MP0003315_abnormal_perineum_morphology1.55006827
35MP0001529_abnormal_vocalization1.54856064
36MP0003136_yellow_coat_color1.54846997
37MP0002396_abnormal_hematopoietic_system1.53788469
38MP0005257_abnormal_intraocular_pressure1.49245018
39MP0002132_abnormal_respiratory_system1.44431590
40MP0004133_heterotaxia1.44129729
41MP0000566_synostosis1.43935592
42MP0001672_abnormal_embryogenesis/_devel1.41193416
43MP0005380_embryogenesis_phenotype1.41193416
44MP0009672_abnormal_birth_weight1.40603140
45MP0000350_abnormal_cell_proliferation1.38500104
46MP0002127_abnormal_cardiovascular_syste1.28344203
47MP0000490_abnormal_crypts_of1.25271484
48MP0000358_abnormal_cell_content/1.24302805
49MP0001188_hyperpigmentation1.23896125
50MP0002751_abnormal_autonomic_nervous1.22294146
51MP0002653_abnormal_ependyma_morphology1.22064850
52MP0001929_abnormal_gametogenesis1.20215772
53MP0002233_abnormal_nose_morphology1.20027132
54MP0003984_embryonic_growth_retardation1.18856998
55MP0002088_abnormal_embryonic_growth/wei1.17260373
56MP0004147_increased_porphyrin_level1.15828491
57MP0000762_abnormal_tongue_morphology1.15054423
58MP0002938_white_spotting1.14965998
59MP0002085_abnormal_embryonic_tissue1.11722541
60MP0000372_irregular_coat_pigmentation1.11244765
61MP0002697_abnormal_eye_size1.10967607
62MP0005408_hypopigmentation1.10596170
63MP0000647_abnormal_sebaceous_gland1.07653469
64MP0000313_abnormal_cell_death1.06711268
65MP0003718_maternal_effect1.05452001
66MP0003567_abnormal_fetal_cardiomyocyte1.04501853
67MP0003787_abnormal_imprinting1.04022376
68MP0005266_abnormal_metabolism1.03091673
69MP0001986_abnormal_taste_sensitivity1.03089249
70MP0003755_abnormal_palate_morphology1.02640704
71MP0003941_abnormal_skin_development1.00311087
72MP0002090_abnormal_vision0.99386059
73MP0002932_abnormal_joint_morphology0.99302584
74MP0004858_abnormal_nervous_system0.98378376
75MP0010307_abnormal_tumor_latency0.97864722
76MP0005391_vision/eye_phenotype0.96782571
77MP0002111_abnormal_tail_morphology0.95448729
78MP0002092_abnormal_eye_morphology0.94582752
79MP0009703_decreased_birth_body0.94572324
80MP0001286_abnormal_eye_development0.94530574
81MP0008877_abnormal_DNA_methylation0.94363478
82MP0002114_abnormal_axial_skeleton0.93815044
83MP0002210_abnormal_sex_determination0.91407696
84MP0005253_abnormal_eye_physiology0.90985924
85MP0001730_embryonic_growth_arrest0.89230459
86MP0004197_abnormal_fetal_growth/weight/0.89066808
87MP0001346_abnormal_lacrimal_gland0.87706901
88MP0009379_abnormal_foot_pigmentation0.87575867
89MP0003937_abnormal_limbs/digits/tail_de0.86486402
90MP0000432_abnormal_head_morphology0.85733275
91MP0002084_abnormal_developmental_patter0.85724217
92MP0001145_abnormal_male_reproductive0.85202514
93MP0002160_abnormal_reproductive_system0.84892432
94MP0002102_abnormal_ear_morphology0.82377126
95MP0002249_abnormal_larynx_morphology0.81793109
96MP0000428_abnormal_craniofacial_morphol0.80516877
97MP0001697_abnormal_embryo_size0.80418426
98MP0008995_early_reproductive_senescence0.79855821
99MP0003186_abnormal_redox_activity0.79767799
100MP0002086_abnormal_extraembryonic_tissu0.79127027
101MP0005084_abnormal_gallbladder_morpholo0.77241076
102MP0003119_abnormal_digestive_system0.76845652
103MP0002116_abnormal_craniofacial_bone0.75844517
104MP0002080_prenatal_lethality0.75136833
105MP0005395_other_phenotype0.73979198
106MP0001984_abnormal_olfaction0.73814598
107MP0000631_abnormal_neuroendocrine_gland0.73665502
108MP0002163_abnormal_gland_morphology0.72902236
109MP0003935_abnormal_craniofacial_develop0.72858439
110MP0010352_gastrointestinal_tract_polyps0.71129493
111MP0003698_abnormal_male_reproductive0.70906222
112MP0004142_abnormal_muscle_tone0.69221896
113MP0002075_abnormal_coat/hair_pigmentati0.69169387
114MP0005379_endocrine/exocrine_gland_phen0.69015913
115MP0001186_pigmentation_phenotype0.67966336
116MP0002752_abnormal_somatic_nervous0.66661716
117MP0003861_abnormal_nervous_system0.65009229
118MP0002837_dystrophic_cardiac_calcinosis0.64663768
119MP0002019_abnormal_tumor_incidence0.64371733
120MP0001119_abnormal_female_reproductive0.63858237
121MP0002098_abnormal_vibrissa_morphology0.62670575
122MP0006036_abnormal_mitochondrial_physio0.62405901
123MP0006072_abnormal_retinal_apoptosis0.61515598
124MP0001324_abnormal_eye_pigmentation0.61221809
125MP0001348_abnormal_lacrimal_gland0.61140336
126MP0005389_reproductive_system_phenotype0.61078120
127MP0001485_abnormal_pinna_reflex0.60486778
128MP0002161_abnormal_fertility/fecundity0.59378508
129MP0000653_abnormal_sex_gland0.59077432
130MP0002095_abnormal_skin_pigmentation0.57254332
131MP0001764_abnormal_homeostasis0.56998338
132MP0002177_abnormal_outer_ear0.56748959
133MP0005384_cellular_phenotype0.56391915
134MP0005332_abnormal_amino_acid0.55000237
135MP0000516_abnormal_urinary_system0.54925456
136MP0005367_renal/urinary_system_phenotyp0.54925456

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.16513661
2Chromosomal breakage induced by crosslinking agents (HP:0003221)5.01440357
3Chromsome breakage (HP:0040012)4.52692937
4Acute necrotizing encephalopathy (HP:0006965)3.68949603
5Meckel diverticulum (HP:0002245)3.54017118
6Nephroblastoma (Wilms tumor) (HP:0002667)3.53638131
7Acute encephalopathy (HP:0006846)3.50391941
8Increased hepatocellular lipid droplets (HP:0006565)3.49747181
9Hypochromic microcytic anemia (HP:0004840)3.48252795
10Microvesicular hepatic steatosis (HP:0001414)3.45819339
11Type I transferrin isoform profile (HP:0003642)3.43793900
12Abnormal lung lobation (HP:0002101)3.40517723
13Rib fusion (HP:0000902)3.38901649
14Reduced antithrombin III activity (HP:0001976)3.35009881
15Abnormality of the ileum (HP:0001549)3.34747917
16Abnormal mitochondria in muscle tissue (HP:0008316)3.33296947
17Embryonal renal neoplasm (HP:0011794)3.29222150
18Multiple enchondromatosis (HP:0005701)3.25482053
19Aplasia/Hypoplasia of the uvula (HP:0010293)3.23232135
20Aplasia/Hypoplasia of the fovea (HP:0008060)3.22919203
21Hypoplasia of the fovea (HP:0007750)3.22919203
223-Methylglutaconic aciduria (HP:0003535)3.19976741
23Hepatoblastoma (HP:0002884)3.18198757
24Lipid accumulation in hepatocytes (HP:0006561)3.15015905
25Rectal fistula (HP:0100590)3.09525222
26Rectovaginal fistula (HP:0000143)3.09525222
27Increased CSF lactate (HP:0002490)3.09248887
28Abnormality of the preputium (HP:0100587)3.00734745
29Supernumerary spleens (HP:0009799)2.99160488
30Mitochondrial inheritance (HP:0001427)2.93569114
31Progressive macrocephaly (HP:0004481)2.89777367
32Progressive external ophthalmoplegia (HP:0000590)2.87977239
33Colon cancer (HP:0003003)2.81617934
34Ependymoma (HP:0002888)2.79623659
35Aplastic anemia (HP:0001915)2.79593632
36Partial duplication of thumb phalanx (HP:0009944)2.79456792
37Cerebral edema (HP:0002181)2.78834768
38Rhabdomyosarcoma (HP:0002859)2.78799285
39Degeneration of anterior horn cells (HP:0002398)2.73725622
40Abnormality of the anterior horn cell (HP:0006802)2.73725622
41Nasolacrimal duct obstruction (HP:0000579)2.70430983
42Breast hypoplasia (HP:0003187)2.67778829
43Small intestinal stenosis (HP:0012848)2.64645073
44Duodenal stenosis (HP:0100867)2.64645073
45Intestinal fistula (HP:0100819)2.63948243
46Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.62153600
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.62153600
48Trismus (HP:0000211)2.61135821
49Birth length less than 3rd percentile (HP:0003561)2.60725132
50Increased serum pyruvate (HP:0003542)2.60021960
51Abnormality of glycolysis (HP:0004366)2.60021960
52Impulsivity (HP:0100710)2.57027571
53Bifid tongue (HP:0010297)2.54847438
54Hepatocellular necrosis (HP:0001404)2.53083919
55Anomalous pulmonary venous return (HP:0010772)2.51480932
56Neoplasm of striated muscle (HP:0009728)2.47944117
57Abnormality of methionine metabolism (HP:0010901)2.46796884
58Pendular nystagmus (HP:0012043)2.46611452
59Abnormality of the fovea (HP:0000493)2.44059492
60Vaginal fistula (HP:0004320)2.43693173
61Microretrognathia (HP:0000308)2.43567257
62Facial cleft (HP:0002006)2.43474958
63Ragged-red muscle fibers (HP:0003200)2.43376388
64Abnormality of aspartate family amino acid metabolism (HP:0010899)2.42786908
65Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.39376350
66Partial duplication of the phalanx of hand (HP:0009999)2.39065263
67Increased serum lactate (HP:0002151)2.38055712
68Triphalangeal thumb (HP:0001199)2.37219513
69Abnormality of chromosome stability (HP:0003220)2.35564902
70Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.34906602
71Intestinal atresia (HP:0011100)2.34628519
72Renal Fanconi syndrome (HP:0001994)2.34438697
73Hepatic necrosis (HP:0002605)2.33519286
74Megaloblastic anemia (HP:0001889)2.32744074
75Fused cervical vertebrae (HP:0002949)2.32611355
76Aplasia/Hypoplasia of the sacrum (HP:0008517)2.32470586
77Macrocytic anemia (HP:0001972)2.31438597
78Duplication of thumb phalanx (HP:0009942)2.29843403
79Abnormality of serum amino acid levels (HP:0003112)2.28832781
80Bone marrow hypocellularity (HP:0005528)2.28065223
81Sloping forehead (HP:0000340)2.25959370
82Hyperglycinemia (HP:0002154)2.25268910
83Aplasia/hypoplasia of the humerus (HP:0006507)2.25266276
84Lactic acidosis (HP:0003128)2.24029858
85Aplasia/Hypoplasia of the sternum (HP:0006714)2.23261730
86Horseshoe kidney (HP:0000085)2.19110847
87Testicular atrophy (HP:0000029)2.18510816
88Volvulus (HP:0002580)2.16571679
89Abnormality of the duodenum (HP:0002246)2.16456394
90Progressive muscle weakness (HP:0003323)2.16429659
91Pancreatic islet-cell hyperplasia (HP:0004510)2.16072892
92Abnormality of the lacrimal duct (HP:0011481)2.15282749
93Increased nuchal translucency (HP:0010880)2.14824045
94Stenosis of the external auditory canal (HP:0000402)2.14728964
95Patellar aplasia (HP:0006443)2.14253109
96Myelodysplasia (HP:0002863)2.13886670
97Septo-optic dysplasia (HP:0100842)2.13512055
98Abnormality of the pulmonary veins (HP:0011718)2.12394867
99Methylmalonic acidemia (HP:0002912)2.12153549
100Increased intramyocellular lipid droplets (HP:0012240)2.09582737
101Reticulocytopenia (HP:0001896)2.05706622
102Cortical dysplasia (HP:0002539)2.05647745
103Abnormality of the phalanges of the hallux (HP:0010057)2.05282790
104Sparse eyelashes (HP:0000653)2.05167598
105Medulloblastoma (HP:0002885)2.04212357
106Cleft eyelid (HP:0000625)2.03455864
107Aplasia/Hypoplasia of the patella (HP:0006498)2.02851156
108Abnormality of the labia minora (HP:0012880)1.99928421
109Leukodystrophy (HP:0002415)1.99662504
110Absent thumb (HP:0009777)1.99464024
111Abnormality of the carotid arteries (HP:0005344)1.99394822
112Ectopic kidney (HP:0000086)1.98880308
113Exercise intolerance (HP:0003546)1.95683097
114Abnormality of cells of the erythroid lineage (HP:0012130)1.94996766
115Atresia of the external auditory canal (HP:0000413)1.94576141
116Rough bone trabeculation (HP:0100670)1.94562779
117Glossoptosis (HP:0000162)1.94093149
118Abnormal protein glycosylation (HP:0012346)1.93696401
119Abnormal glycosylation (HP:0012345)1.93696401
120Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.93696401
121Abnormal protein N-linked glycosylation (HP:0012347)1.93696401
122Abnormal number of erythroid precursors (HP:0012131)1.93404754
123Absent radius (HP:0003974)1.88729416
124Neoplasm of the colon (HP:0100273)1.87452508
125Tongue fasciculations (HP:0001308)1.87285536
126Abnormality of the nasolacrimal system (HP:0000614)1.86283501
127Short humerus (HP:0005792)1.85991528
128Abnormality of the salivary glands (HP:0010286)1.84855376
129Aplasia/Hypoplasia of the macula (HP:0008059)1.84274331
130Tracheoesophageal fistula (HP:0002575)1.83971585
131Clubbing of toes (HP:0100760)1.83864700
132Pancreatic fibrosis (HP:0100732)1.83425252
133Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.83307827
134Premature ovarian failure (HP:0008209)1.83080609
135Absent septum pellucidum (HP:0001331)1.82848090
136Preauricular pit (HP:0004467)1.81097875
137Periauricular skin pits (HP:0100277)1.81097875
138Gastrointestinal atresia (HP:0002589)1.80431682
139Methylmalonic aciduria (HP:0012120)1.78663663
140Shawl scrotum (HP:0000049)1.78540924
141Horizontal nystagmus (HP:0000666)1.78134735
142Hyperinsulinemic hypoglycemia (HP:0000825)1.78081375
143Embryonal neoplasm (HP:0002898)1.77925992
144Absent forearm bone (HP:0003953)1.77799766
145Aplasia involving forearm bones (HP:0009822)1.77799766
146Respiratory difficulties (HP:0002880)1.76143803
147Cerebral hypomyelination (HP:0006808)1.76067398
148Abnormality of glycine metabolism (HP:0010895)1.75115138
149Abnormality of serine family amino acid metabolism (HP:0010894)1.75115138
150Respiratory failure (HP:0002878)1.75051909
151Hypoplastic pelvis (HP:0008839)1.74429115
152Lethargy (HP:0001254)1.74034276
153Exertional dyspnea (HP:0002875)1.72097607
154Choanal atresia (HP:0000453)1.71509461
155Median cleft lip (HP:0000161)1.69892489
156Preaxial hand polydactyly (HP:0001177)1.67685524
157Neoplasm of the adrenal gland (HP:0100631)1.67129620
158Glioma (HP:0009733)1.66273196

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK125.56014544
2GRK53.36494795
3ADRBK23.04179183
4NEK13.02219123
5BUB12.98851481
6GRK12.92909270
7TTK2.74961802
8VRK22.74534678
9STK162.61990090
10SRPK12.40752578
11GRK62.32330616
12EIF2AK12.30872932
13GRK72.30598028
14WEE12.11189298
15TRIM281.94419645
16CDK71.94198004
17CSF1R1.87898851
18CDC71.81959665
19PLK11.79902131
20MKNK21.78770527
21EIF2AK21.65385597
22MKNK11.61970774
23VRK11.61702608
24CHEK21.61574557
25ZAK1.58199787
26EIF2AK31.57045127
27NUAK11.56693071
28MAPK71.54593191
29ACVR1B1.50555260
30AKT31.50479650
31TAF11.48188656
32TGFBR21.48011876
33TLK11.45807631
34PLK41.45090128
35MATK1.36646922
36WNK31.33924078
37STK101.28766325
38DYRK31.26494022
39EPHA21.22703089
40BRSK21.22406825
41ERN11.19553013
42NME21.16804101
43DYRK21.11037535
44IRAK31.10676196
45PDK21.10134704
46MOS1.04072302
47CASK1.04021375
48IRAK41.02432199
49AURKB0.99680640
50PLK20.98635030
51PNCK0.96925544
52AURKA0.96049283
53CDK80.95648686
54CAMK40.94498129
55CHEK10.91008966
56ATR0.90059978
57STK30.89790362
58BCKDK0.89439639
59WNK10.86716600
60ADRBK10.86329821
61TSSK60.86287356
62CSNK1G10.84485214
63PRKG20.83405030
64RPS6KB20.82017071
65TNIK0.81923373
66PAK40.81628030
67ALK0.80678103
68PRKCI0.80528510
69MAP2K60.79651734
70PLK30.79308658
71PRPF4B0.78774806
72YES10.78566460
73CCNB10.78385800
74PBK0.77423979
75BCR0.74369017
76BRAF0.73430967
77STK390.71018640
78RPS6KA40.70311287
79PIM20.67890257
80NEK20.66726543
81MST40.65674937
82ERBB30.65309056
83PASK0.64954784
84TESK20.62597735
85OXSR10.62402298
86ATM0.61985040
87FGFR10.61932483
88BRD40.58093842
89ERBB40.57350963
90CSNK1G30.57334464
91CDK20.57081230
92BMPR1B0.55514273
93BRSK10.55493065
94TXK0.55285528
95CSNK1E0.54787277
96MAP3K80.54203629
97IRAK20.53545454
98HIPK20.53088350
99AKT20.52694965
100NME10.52645373
101TYRO30.52126403
102TAOK20.49410512
103STK38L0.48408512
104IKBKB0.48153681
105CSNK1G20.47967286
106TEC0.47505153
107CSNK2A10.47269412
108IRAK10.47087454
109CDK60.46337910
110CDK10.46046845
111CDK30.43779352
112CDK190.41882350
113BLK0.41566835
114SCYL20.40485881
115SIK30.39867912
116RPS6KA50.39618636
117PRKDC0.38807851
118MAP3K40.37656833
119STK40.37234704
120EPHA40.36631482
121PAK10.34568551
122CSNK2A20.33888368
123MUSK0.33867121
124MAP3K90.29800819
125MAP4K20.28786436
126MINK10.28370139
127PRKCG0.27753196
128PRKCD0.27749208
129CDK40.26058006
130PIM10.25983773
131CSNK1A1L0.25863404
132DAPK10.25299794
133MARK20.25238323
134MAP3K120.25158806
135DYRK1A0.24635274
136NEK60.24408459
137CLK10.24186616
138PRKACB0.22281752
139TGFBR10.21468385
140PINK10.20324270
141PRKCE0.20063548
142CSNK1A10.19856075

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.29717236
2DNA replication_Homo sapiens_hsa030303.76906560
3RNA polymerase_Homo sapiens_hsa030203.69923027
4Ribosome_Homo sapiens_hsa030103.66873166
5Mismatch repair_Homo sapiens_hsa034303.28921961
6Vitamin B6 metabolism_Homo sapiens_hsa007502.97786184
7Proteasome_Homo sapiens_hsa030502.96725661
8Homologous recombination_Homo sapiens_hsa034402.89228854
9Fanconi anemia pathway_Homo sapiens_hsa034602.77953977
10Spliceosome_Homo sapiens_hsa030402.74232783
11RNA transport_Homo sapiens_hsa030132.51853782
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.46192872
13Base excision repair_Homo sapiens_hsa034102.35576161
14Nucleotide excision repair_Homo sapiens_hsa034202.33714080
15Basal transcription factors_Homo sapiens_hsa030222.26715065
16Pyrimidine metabolism_Homo sapiens_hsa002402.26639381
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.06135032
18Cell cycle_Homo sapiens_hsa041102.02761431
19RNA degradation_Homo sapiens_hsa030181.96316619
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.93275306
21Arachidonic acid metabolism_Homo sapiens_hsa005901.84691568
22One carbon pool by folate_Homo sapiens_hsa006701.74281232
23Propanoate metabolism_Homo sapiens_hsa006401.70127524
24mRNA surveillance pathway_Homo sapiens_hsa030151.69830283
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.64129400
26Pyruvate metabolism_Homo sapiens_hsa006201.62856184
27Non-homologous end-joining_Homo sapiens_hsa034501.61334872
28Fructose and mannose metabolism_Homo sapiens_hsa000511.41369862
29Fatty acid elongation_Homo sapiens_hsa000621.38889598
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.38102031
31Purine metabolism_Homo sapiens_hsa002301.37791974
32Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.33958676
33Oxidative phosphorylation_Homo sapiens_hsa001901.30508065
34Steroid biosynthesis_Homo sapiens_hsa001001.29817373
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.29529262
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.27861723
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27212979
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27002846
39p53 signaling pathway_Homo sapiens_hsa041151.22241154
40Biosynthesis of amino acids_Homo sapiens_hsa012301.21697650
41Carbon metabolism_Homo sapiens_hsa012001.21658839
42Parkinsons disease_Homo sapiens_hsa050121.19524771
43Phototransduction_Homo sapiens_hsa047441.19027017
44Linoleic acid metabolism_Homo sapiens_hsa005911.18308532
45Huntingtons disease_Homo sapiens_hsa050161.18219930
46Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.08162076
47Selenocompound metabolism_Homo sapiens_hsa004501.03104634
48Galactose metabolism_Homo sapiens_hsa000520.99583362
49Protein export_Homo sapiens_hsa030600.99550553
50alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95098554
51Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.91271731
52Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88416951
53Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.86998401
54Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.86012295
55Herpes simplex infection_Homo sapiens_hsa051680.75595222
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74589083
57Ether lipid metabolism_Homo sapiens_hsa005650.69752143
58Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69320797
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.67755355
60Folate biosynthesis_Homo sapiens_hsa007900.65634652
61Epstein-Barr virus infection_Homo sapiens_hsa051690.64870518
62Basal cell carcinoma_Homo sapiens_hsa052170.64049121
63Thyroid cancer_Homo sapiens_hsa052160.63532838
64Systemic lupus erythematosus_Homo sapiens_hsa053220.63137811
65Fatty acid metabolism_Homo sapiens_hsa012120.62360483
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.61512948
67Other glycan degradation_Homo sapiens_hsa005110.60791598
68Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59831175
69Sulfur relay system_Homo sapiens_hsa041220.58246537
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.57545125
71Fatty acid degradation_Homo sapiens_hsa000710.56337458
72Alzheimers disease_Homo sapiens_hsa050100.55921205
73Cardiac muscle contraction_Homo sapiens_hsa042600.55140222
74Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.53296870
75Regulation of autophagy_Homo sapiens_hsa041400.50911824
76Arginine and proline metabolism_Homo sapiens_hsa003300.50603624
77Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.50574118
78Primary immunodeficiency_Homo sapiens_hsa053400.50411352
79Metabolic pathways_Homo sapiens_hsa011000.50179936
80Glutathione metabolism_Homo sapiens_hsa004800.50045894
81N-Glycan biosynthesis_Homo sapiens_hsa005100.49179427
82beta-Alanine metabolism_Homo sapiens_hsa004100.48888834
83Intestinal immune network for IgA production_Homo sapiens_hsa046720.48311537
84Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.48042369
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47697331
86Autoimmune thyroid disease_Homo sapiens_hsa053200.46541909
87Butanoate metabolism_Homo sapiens_hsa006500.45647843
88Sphingolipid metabolism_Homo sapiens_hsa006000.44964118
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44438795
90Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.43606033
91Sulfur metabolism_Homo sapiens_hsa009200.43263430
92Cyanoamino acid metabolism_Homo sapiens_hsa004600.43230798
93Peroxisome_Homo sapiens_hsa041460.42754522
94Asthma_Homo sapiens_hsa053100.39587474
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36432196
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.34204269
97Pentose phosphate pathway_Homo sapiens_hsa000300.33211222
98Hedgehog signaling pathway_Homo sapiens_hsa043400.32939681
99Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32856001
100HTLV-I infection_Homo sapiens_hsa051660.32795526
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32286445
102Allograft rejection_Homo sapiens_hsa053300.32257089
103Lysine degradation_Homo sapiens_hsa003100.31478996
104Pathways in cancer_Homo sapiens_hsa052000.29873327
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.28921604
106NF-kappa B signaling pathway_Homo sapiens_hsa040640.28694350
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.28044685
108Vitamin digestion and absorption_Homo sapiens_hsa049770.27897618
109Viral carcinogenesis_Homo sapiens_hsa052030.27257587
110Wnt signaling pathway_Homo sapiens_hsa043100.27044427
111Oocyte meiosis_Homo sapiens_hsa041140.26807874
112TGF-beta signaling pathway_Homo sapiens_hsa043500.26390215
113Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25936606
114Collecting duct acid secretion_Homo sapiens_hsa049660.25191585
115Chemical carcinogenesis_Homo sapiens_hsa052040.24192195
116Hippo signaling pathway_Homo sapiens_hsa043900.23833976
117Hematopoietic cell lineage_Homo sapiens_hsa046400.22400481
118MicroRNAs in cancer_Homo sapiens_hsa052060.22380164
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.21937444
120Tryptophan metabolism_Homo sapiens_hsa003800.21503123
121Primary bile acid biosynthesis_Homo sapiens_hsa001200.20607235
122Ovarian steroidogenesis_Homo sapiens_hsa049130.20349278
123Alcoholism_Homo sapiens_hsa050340.19993253
124Graft-versus-host disease_Homo sapiens_hsa053320.19394347
125Retinol metabolism_Homo sapiens_hsa008300.18983913
126Nitrogen metabolism_Homo sapiens_hsa009100.18104380
127Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.17823594
128Arginine biosynthesis_Homo sapiens_hsa002200.17589708
129Notch signaling pathway_Homo sapiens_hsa043300.17254475
130Taste transduction_Homo sapiens_hsa047420.17087069
131Serotonergic synapse_Homo sapiens_hsa047260.16803414
132Fat digestion and absorption_Homo sapiens_hsa049750.15831124
133SNARE interactions in vesicular transport_Homo sapiens_hsa041300.15013892
134Drug metabolism - other enzymes_Homo sapiens_hsa009830.13986370
135Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.12661324
136Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.12395235
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.11194593
138Caffeine metabolism_Homo sapiens_hsa002320.11095486
139Antigen processing and presentation_Homo sapiens_hsa046120.11082691
140Vibrio cholerae infection_Homo sapiens_hsa051100.09263496

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