NIFK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that interacts with the forkhead-associated domain of the Ki-67 antigen. The encoded protein may bind RNA and may play a role in mitosis and cell cycle progression. Multiple pseudogenes exist on chromosomes 5, 10, 12, 15, and 19. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chaperone-mediated protein transport (GO:0072321)5.74960669
2maturation of SSU-rRNA (GO:0030490)5.16451666
3ribosomal small subunit assembly (GO:0000028)5.02787449
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.83399352
5formation of translation preinitiation complex (GO:0001731)4.73200875
6activation of MAPKKK activity (GO:0000185)4.68312164
7nucleobase biosynthetic process (GO:0046112)4.64740907
8DNA strand elongation involved in DNA replication (GO:0006271)4.60163683
9purine nucleobase biosynthetic process (GO:0009113)4.52839767
10viral transcription (GO:0019083)4.51396216
11DNA deamination (GO:0045006)4.49766369
12establishment of viral latency (GO:0019043)4.49653825
13translational termination (GO:0006415)4.49619773
14positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)4.45967204
15ribosomal large subunit biogenesis (GO:0042273)4.44995345
16ribosome biogenesis (GO:0042254)4.43530668
17DNA replication initiation (GO:0006270)4.40080904
18DNA strand elongation (GO:0022616)4.39526609
19ribonucleoprotein complex biogenesis (GO:0022613)4.37204109
20establishment of protein localization to mitochondrial membrane (GO:0090151)4.37144583
21ribosomal small subunit biogenesis (GO:0042274)4.33276723
22telomere maintenance via semi-conservative replication (GO:0032201)4.30549502
23transcription from mitochondrial promoter (GO:0006390)4.29643960
24mitotic metaphase plate congression (GO:0007080)4.22390715
25ribosome assembly (GO:0042255)4.20369589
26DNA replication checkpoint (GO:0000076)4.16307459
27translational initiation (GO:0006413)4.10288845
28energy coupled proton transport, down electrochemical gradient (GO:0015985)4.08659894
29ATP synthesis coupled proton transport (GO:0015986)4.08659894
30translational elongation (GO:0006414)4.06569236
31DNA unwinding involved in DNA replication (GO:0006268)4.04448642
32protein localization to kinetochore (GO:0034501)4.01503843
33IMP biosynthetic process (GO:0006188)3.99041065
34rRNA processing (GO:0006364)3.95497540
35telomere maintenance via recombination (GO:0000722)3.92170528
36SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.86679371
37spliceosomal snRNP assembly (GO:0000387)3.86225840
38exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.85522245
39CENP-A containing nucleosome assembly (GO:0034080)3.83800560
40nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.81164204
41* rRNA metabolic process (GO:0016072)3.78980405
42chromatin remodeling at centromere (GO:0031055)3.78562867
43pseudouridine synthesis (GO:0001522)3.78026419
44cotranslational protein targeting to membrane (GO:0006613)3.77455834
45nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.76752506
46protein targeting to ER (GO:0045047)3.75416796
47mitotic recombination (GO:0006312)3.69458201
48regulation of mitotic spindle checkpoint (GO:1903504)3.67985378
49regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.67985378
50resolution of meiotic recombination intermediates (GO:0000712)3.67771165
51rRNA modification (GO:0000154)3.63952476
52mitotic nuclear envelope disassembly (GO:0007077)3.63230976
53folic acid-containing compound biosynthetic process (GO:0009396)3.60883585
54IMP metabolic process (GO:0046040)3.58757082
55transcription from RNA polymerase I promoter (GO:0006360)3.58107680
56metaphase plate congression (GO:0051310)3.57865374
57establishment of protein localization to endoplasmic reticulum (GO:0072599)3.56576977
58protein localization to endoplasmic reticulum (GO:0070972)3.54983228
59mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.53408978
60cellular protein complex disassembly (GO:0043624)3.53008419
61proteasome assembly (GO:0043248)3.52847624
62viral life cycle (GO:0019058)3.50844771
63telomere maintenance via telomere lengthening (GO:0010833)3.49812467
64mitochondrial RNA metabolic process (GO:0000959)3.46610105
65DNA replication-independent nucleosome assembly (GO:0006336)3.45878184
66DNA replication-independent nucleosome organization (GO:0034724)3.45878184
67leukocyte aggregation (GO:0070486)3.43578983
68meiotic chromosome segregation (GO:0045132)3.42313721
69negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.42296797
70protein localization to chromosome, centromeric region (GO:0071459)3.42045858
71DNA replication-dependent nucleosome assembly (GO:0006335)3.40411663
72DNA replication-dependent nucleosome organization (GO:0034723)3.40411663
73anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.38856320
74protein targeting to mitochondrion (GO:0006626)3.38321157
75termination of RNA polymerase III transcription (GO:0006386)3.37714893
76transcription elongation from RNA polymerase III promoter (GO:0006385)3.37714893
77nucleotide-excision repair, DNA gap filling (GO:0006297)3.37632057
78regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.36304915
79regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.35136463
80cellular component biogenesis (GO:0044085)3.34369589
81positive regulation of signal transduction by p53 class mediator (GO:1901798)3.34260309
82membrane disassembly (GO:0030397)3.33601501
83nuclear envelope disassembly (GO:0051081)3.33601501
84translation (GO:0006412)3.33333096
85nuclear pore organization (GO:0006999)3.32612328
86positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.32390559
87maturation of 5.8S rRNA (GO:0000460)3.29514117
88signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.26472185
89signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.26472185
90signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.26472185
91signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.23339148
92intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.23339148
93respiratory electron transport chain (GO:0022904)3.21525605
94kinetochore organization (GO:0051383)3.21256390
95regulation of spindle organization (GO:0090224)3.20676838
96histone exchange (GO:0043486)3.20148260
97folic acid metabolic process (GO:0046655)3.19955436
98DNA-templated transcription, termination (GO:0006353)3.19769989
99transcription-coupled nucleotide-excision repair (GO:0006283)3.18508995
100signal transduction involved in DNA damage checkpoint (GO:0072422)3.18320978
101signal transduction involved in DNA integrity checkpoint (GO:0072401)3.18320978
102regulation of mitochondrial translation (GO:0070129)3.17678290
103protein complex disassembly (GO:0043241)3.16352143
104mitochondrial respiratory chain complex assembly (GO:0033108)3.15753786
105spliceosomal complex assembly (GO:0000245)3.13928701
106signal transduction involved in cell cycle checkpoint (GO:0072395)3.13192262
107viral mRNA export from host cell nucleus (GO:0046784)3.12352014
108electron transport chain (GO:0022900)3.12277687
109mitochondrial respiratory chain complex I assembly (GO:0032981)3.11536499
110NADH dehydrogenase complex assembly (GO:0010257)3.11536499
111mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.11536499
112nuclear-transcribed mRNA catabolic process (GO:0000956)3.11427954
113negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.10755568
114negative regulation of ligase activity (GO:0051352)3.10755568
115cell cycle G1/S phase transition (GO:0044843)3.10576954
116G1/S transition of mitotic cell cycle (GO:0000082)3.10576954
117establishment of integrated proviral latency (GO:0075713)3.08468277
118establishment of chromosome localization (GO:0051303)3.08153430
119nuclear pore complex assembly (GO:0051292)3.07553642
120kinetochore assembly (GO:0051382)3.06809844
121attachment of spindle microtubules to kinetochore (GO:0008608)3.05709382
122termination of RNA polymerase I transcription (GO:0006363)3.04328413
123transcription elongation from RNA polymerase I promoter (GO:0006362)3.03870314
124macromolecular complex disassembly (GO:0032984)3.03218708
125ncRNA processing (GO:0034470)3.01733793
126deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.01177819
1277-methylguanosine mRNA capping (GO:0006370)3.00498923
128rRNA methylation (GO:0031167)2.97219896
1297-methylguanosine RNA capping (GO:0009452)2.96553720
130RNA capping (GO:0036260)2.96553720
131positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.95838407
132mRNA catabolic process (GO:0006402)2.95555618
133RNA splicing, via transesterification reactions (GO:0000375)2.95219689
134DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.93781796
135mRNA splicing, via spliceosome (GO:0000398)2.93482246
136RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.93482246
137RNA catabolic process (GO:0006401)2.92719689

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.68496863
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.79717898
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.91066619
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.55582663
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.45441028
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.34156417
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.30748275
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.23557001
9JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.17563419
10ETS1_20019798_ChIP-Seq_JURKAT_Human3.15138814
11FOXM1_23109430_ChIP-Seq_U2OS_Human3.14111095
12MYC_18358816_ChIP-ChIP_MESCs_Mouse3.06751711
13MYC_19030024_ChIP-ChIP_MESCs_Mouse3.04208681
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.88456350
15* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.86110962
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.60692093
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.47559260
18XRN2_22483619_ChIP-Seq_HELA_Human2.47425300
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.46520202
20VDR_23849224_ChIP-Seq_CD4+_Human2.45616137
21CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.40930494
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.29604056
23FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.21991156
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.20308915
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.17834921
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.14645360
27DCP1A_22483619_ChIP-Seq_HELA_Human2.13067929
28FOXP3_21729870_ChIP-Seq_TREG_Human2.12056140
29AR_21909140_ChIP-Seq_LNCAP_Human2.08736685
30HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03607209
31GABP_19822575_ChIP-Seq_HepG2_Human2.03013173
32TTF2_22483619_ChIP-Seq_HELA_Human1.99014487
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91993601
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.89881096
35SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89647683
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.87703450
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.87466477
38PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86522338
39E2F1_21310950_ChIP-Seq_MCF-7_Human1.82429438
40ELK1_19687146_ChIP-ChIP_HELA_Human1.79908511
41POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.78181015
42CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.75110219
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.73534660
44TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.68102857
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.65867502
46KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.65282560
47YY1_21170310_ChIP-Seq_MESCs_Mouse1.63310049
48NANOG_18555785_ChIP-Seq_MESCs_Mouse1.62574392
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62566132
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.59750628
51ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55184219
52SRF_21415370_ChIP-Seq_HL-1_Mouse1.51805841
53CIITA_25753668_ChIP-Seq_RAJI_Human1.51534552
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.49603936
55KDM5A_27292631_Chip-Seq_BREAST_Human1.47251030
56EWS_26573619_Chip-Seq_HEK293_Human1.40705389
57MYC_22102868_ChIP-Seq_BL_Human1.39490591
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.39124316
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35866836
60SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.35716338
61ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35216901
62FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33821485
63STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24928191
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22661530
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22373157
66PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.21475375
67KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19710613
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.18643126
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.18214472
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.16417592
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.15856004
72FUS_26573619_Chip-Seq_HEK293_Human1.14175433
73FLI1_27457419_Chip-Seq_LIVER_Mouse1.13885313
74RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12379027
75CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11879858
76E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11268861
77ELK1_22589737_ChIP-Seq_MCF10A_Human1.10564858
78TFEB_21752829_ChIP-Seq_HELA_Human1.10463718
79MYC_18940864_ChIP-ChIP_HL60_Human1.09217894
80KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.08738545
81DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.06229598
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.04066303
83NANOG_16153702_ChIP-ChIP_HESCs_Human1.01617542
84SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01018631
85SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.00771240
86HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00752832
87BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00402291
88NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.96936004
89SALL1_21062744_ChIP-ChIP_HESCs_Human0.96806635
90SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.96791170
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.96567857
92SOX17_20123909_ChIP-Seq_XEN_Mouse0.96159698
93POU5F1_16153702_ChIP-ChIP_HESCs_Human0.95902475
94CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95812913
95SOX2_16153702_ChIP-ChIP_HESCs_Human0.95028537
96GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93747417
97SPI1_23547873_ChIP-Seq_NB4_Human0.92093995
98CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91822819
99CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90900636
100VDR_22108803_ChIP-Seq_LS180_Human0.88220378
101CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85312288
102KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.84793814
103PCGF2_27294783_Chip-Seq_ESCs_Mouse0.84050702
104CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83921393
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.77985772
106ELF5_23300383_ChIP-Seq_T47D_Human0.77622601
107HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.77182586
108TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.76709970
109TCF3_18692474_ChIP-Seq_MEFs_Mouse0.75805007
110TP53_22573176_ChIP-Seq_HFKS_Human0.75197904
111FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75091929
112OCT4_18692474_ChIP-Seq_MEFs_Mouse0.74219431
113VDR_21846776_ChIP-Seq_THP-1_Human0.73359742
114SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.72663013
115NANOG_21062744_ChIP-ChIP_HESCs_Human0.72552176
116SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.71724321
117CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.67979072
118ZNF274_21170338_ChIP-Seq_K562_Hela0.63019452
119EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.62443092
120NFE2_27457419_Chip-Seq_LIVER_Mouse0.61341733

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.16942798
2MP0005623_abnormal_meninges_morphology5.63212627
3MP0004957_abnormal_blastocyst_morpholog4.81398494
4MP0010094_abnormal_chromosome_stability4.59029396
5MP0003111_abnormal_nucleus_morphology4.45638342
6MP0003077_abnormal_cell_cycle4.09687000
7MP0008057_abnormal_DNA_replication4.01831240
8MP0008058_abnormal_DNA_repair3.58655076
9MP0008007_abnormal_cellular_replicative3.03267235
10MP0008932_abnormal_embryonic_tissue2.86985242
11MP0002396_abnormal_hematopoietic_system2.56430065
12MP0003123_paternal_imprinting2.46591213
13MP0001730_embryonic_growth_arrest2.45216929
14MP0000350_abnormal_cell_proliferation2.28391323
15MP0003786_premature_aging2.20645716
16MP0009384_cardiac_valve_regurgitation2.03312530
17MP0003718_maternal_effect2.01037427
18MP0010352_gastrointestinal_tract_polyps1.96333772
19MP0000490_abnormal_crypts_of1.89594057
20MP0009333_abnormal_splenocyte_physiolog1.73193285
21MP0001697_abnormal_embryo_size1.73099461
22MP0010307_abnormal_tumor_latency1.68198174
23MP0008877_abnormal_DNA_methylation1.66100239
24MP0001672_abnormal_embryogenesis/_devel1.64702404
25MP0005380_embryogenesis_phenotype1.64702404
26MP0000762_abnormal_tongue_morphology1.61339091
27MP0002080_prenatal_lethality1.60622393
28MP0003806_abnormal_nucleotide_metabolis1.54755758
29MP0004808_abnormal_hematopoietic_stem1.52144497
30MP0000313_abnormal_cell_death1.50097746
31MP0002019_abnormal_tumor_incidence1.48349257
32MP0003984_embryonic_growth_retardation1.44935278
33MP0002088_abnormal_embryonic_growth/wei1.41183986
34MP0002085_abnormal_embryonic_tissue1.39999788
35MP0003567_abnormal_fetal_cardiomyocyte1.39885671
36MP0003385_abnormal_body_wall1.37645988
37MP0005397_hematopoietic_system_phenotyp1.36731184
38MP0001545_abnormal_hematopoietic_system1.36731184
39MP0009379_abnormal_foot_pigmentation1.34585487
40MP0000013_abnormal_adipose_tissue1.34523024
41MP0004147_increased_porphyrin_level1.33430555
42MP0002084_abnormal_developmental_patter1.30127314
43MP0003186_abnormal_redox_activity1.29093450
44MP0003763_abnormal_thymus_physiology1.28941489
45MP0006072_abnormal_retinal_apoptosis1.27313384
46MP0002086_abnormal_extraembryonic_tissu1.27301438
47MP0004197_abnormal_fetal_growth/weight/1.26135967
48MP0003315_abnormal_perineum_morphology1.24446051
49MP0002210_abnormal_sex_determination1.20381522
50MP0006292_abnormal_olfactory_placode1.19172853
51MP0002277_abnormal_respiratory_mucosa1.15413622
52MP0000703_abnormal_thymus_morphology1.08522477
53MP0001293_anophthalmia1.07584589
54MP0000358_abnormal_cell_content/1.07224224
55MP0002638_abnormal_pupillary_reflex1.06992676
56MP0002177_abnormal_outer_ear1.06719006
57MP0002722_abnormal_immune_system1.05614446
58MP0001145_abnormal_male_reproductive1.05482325
59MP0002398_abnormal_bone_marrow1.04790523
60MP0000689_abnormal_spleen_morphology1.04285039
61MP0010030_abnormal_orbit_morphology1.04023532
62MP0002160_abnormal_reproductive_system1.03690349
63MP0003890_abnormal_embryonic-extraembry1.01350792
64MP0003136_yellow_coat_color0.95846211
65MP0002163_abnormal_gland_morphology0.95768668
66MP0003221_abnormal_cardiomyocyte_apopto0.94131447
67MP0006036_abnormal_mitochondrial_physio0.92635908
68MP0001529_abnormal_vocalization0.92276871
69MP0000653_abnormal_sex_gland0.92200536
70MP0002132_abnormal_respiratory_system0.91948853
71MP0001853_heart_inflammation0.91544092
72MP0005389_reproductive_system_phenotype0.89836420
73MP0001929_abnormal_gametogenesis0.87508842
74MP0003121_genomic_imprinting0.86226366
75MP0001119_abnormal_female_reproductive0.86109327
76MP0002429_abnormal_blood_cell0.83891179
77MP0003119_abnormal_digestive_system0.83729729
78MP0001881_abnormal_mammary_gland0.82325940
79MP0008873_increased_physiological_sensi0.81853406
80MP0005501_abnormal_skin_physiology0.81695148
81MP0003755_abnormal_palate_morphology0.81594929
82MP0005551_abnormal_eye_electrophysiolog0.79943151
83MP0005410_abnormal_fertilization0.79842002
84MP0006035_abnormal_mitochondrial_morpho0.79605135
85MP0002269_muscular_atrophy0.79565808
86MP0008770_decreased_survivor_rate0.79009626
87MP0000372_irregular_coat_pigmentation0.78981599
88MP0003698_abnormal_male_reproductive0.78278476
89MP0002111_abnormal_tail_morphology0.77819895
90MP0005408_hypopigmentation0.76221312
91MP0005671_abnormal_response_to0.75870657
92MP0006054_spinal_hemorrhage0.75320097
93MP0000858_altered_metastatic_potential0.75218164
94MP0008789_abnormal_olfactory_epithelium0.75021608
95MP0005384_cellular_phenotype0.74328250
96MP0002095_abnormal_skin_pigmentation0.73940167
97MP0004133_heterotaxia0.72385314
98MP0001919_abnormal_reproductive_system0.71718557
99MP0009250_abnormal_appendicular_skeleto0.70590734
100MP0003656_abnormal_erythrocyte_physiolo0.69947194
101MP0005075_abnormal_melanosome_morpholog0.69857787
102MP0005023_abnormal_wound_healing0.68951315
103MP0009672_abnormal_birth_weight0.68151297
104MP0000716_abnormal_immune_system0.68013837
105MP0005084_abnormal_gallbladder_morpholo0.65522187
106MP0009697_abnormal_copulation0.64541751
107MP0002736_abnormal_nociception_after0.64487543
108MP0005379_endocrine/exocrine_gland_phen0.64354897
109MP0000465_gastrointestinal_hemorrhage0.64240172
110MP0000537_abnormal_urethra_morphology0.63962591
111MP0009053_abnormal_anal_canal0.63783811
112MP0005621_abnormal_cell_physiology0.62826610
113MP0002938_white_spotting0.62601661
114MP0003936_abnormal_reproductive_system0.62525271
115MP0000477_abnormal_intestine_morphology0.61474926
116MP0002161_abnormal_fertility/fecundity0.61430229
117MP0001286_abnormal_eye_development0.61247598
118MP0002233_abnormal_nose_morphology0.61156383
119MP0002102_abnormal_ear_morphology0.59805340
120MP0000647_abnormal_sebaceous_gland0.58745028
121MP0004215_abnormal_myocardial_fiber0.58669547
122MP0003115_abnormal_respiratory_system0.58066864
123MP0005395_other_phenotype0.57888068
124MP0001764_abnormal_homeostasis0.56880336
125MP0000049_abnormal_middle_ear0.56753130
126MP0002697_abnormal_eye_size0.56474577
127MP0005266_abnormal_metabolism0.55213531
128MP0008260_abnormal_autophagy0.54312206
129MP0005076_abnormal_cell_differentiation0.53692060
130MP0003941_abnormal_skin_development0.53665070
131MP0002751_abnormal_autonomic_nervous0.50588927
132MP0000750_abnormal_muscle_regeneration0.50298252
133MP0001800_abnormal_humoral_immune0.49736719
134MP0002282_abnormal_trachea_morphology0.49653069
135MP0002092_abnormal_eye_morphology0.48952914
136MP0003937_abnormal_limbs/digits/tail_de0.48935140
137MP0001542_abnormal_bone_strength0.48057158
138MP0001915_intracranial_hemorrhage0.48014772
139MP0003699_abnormal_female_reproductive0.48014179

Predicted human phenotypes

RankGene SetZ-score
1Cerebellar dysplasia (HP:0007033)7.19109241
2Hypoplasia of the pons (HP:0012110)7.14570940
3Abnormality of the pons (HP:0007361)6.66571887
4Type II lissencephaly (HP:0007260)6.41615296
5Retinal atrophy (HP:0001105)6.36440316
6Retinal dysplasia (HP:0007973)5.67802577
7Birth length less than 3rd percentile (HP:0003561)5.43872938
8Abnormality of cells of the erythroid lineage (HP:0012130)5.00185895
9Fatigue (HP:0012378)4.93430527
10Abnormal number of erythroid precursors (HP:0012131)4.74638282
11Decreased electroretinogram (ERG) amplitude (HP:0000654)4.73257719
12Reticulocytopenia (HP:0001896)4.63261973
13Breast hypoplasia (HP:0003187)4.16440354
14Oral leukoplakia (HP:0002745)4.00514783
15Aplasia/Hypoplasia affecting the retina (HP:0008061)3.95345898
16Acute necrotizing encephalopathy (HP:0006965)3.77006509
17Abolished electroretinogram (ERG) (HP:0000550)3.75407829
18Macrocytic anemia (HP:0001972)3.63172035
19Colon cancer (HP:0003003)3.61211861
20Rough bone trabeculation (HP:0100670)3.52741421
21Degeneration of anterior horn cells (HP:0002398)3.48867691
22Abnormality of the anterior horn cell (HP:0006802)3.48867691
23Aplastic anemia (HP:0001915)3.47498984
24Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.39823728
25Carpal bone hypoplasia (HP:0001498)3.39741512
26Buphthalmos (HP:0000557)3.38373244
27Difficulty climbing stairs (HP:0003551)3.34769034
28Abnormal mitochondria in muscle tissue (HP:0008316)3.34451026
29Cerebral hypomyelination (HP:0006808)3.32578902
30Pallor (HP:0000980)3.26842434
31Acute encephalopathy (HP:0006846)3.24089585
32Increased hepatocellular lipid droplets (HP:0006565)3.22961970
33Lipid accumulation in hepatocytes (HP:0006561)3.22496536
34Patellar aplasia (HP:0006443)3.15684876
35Mitochondrial inheritance (HP:0001427)3.04443299
36Increased CSF lactate (HP:0002490)3.02266438
37Progressive macrocephaly (HP:0004481)3.00816996
38Aplasia/Hypoplasia of the patella (HP:0006498)2.97057735
39Selective tooth agenesis (HP:0001592)2.93187918
40Microretrognathia (HP:0000308)2.90265068
41Abnormality of the preputium (HP:0100587)2.76369712
42Glossoptosis (HP:0000162)2.69977059
43Irregular epiphyses (HP:0010582)2.68567201
44Multiple enchondromatosis (HP:0005701)2.67728706
45Meckel diverticulum (HP:0002245)2.66865052
46Poikiloderma (HP:0001029)2.66688664
47IgG deficiency (HP:0004315)2.66602359
4811 pairs of ribs (HP:0000878)2.65914286
49Trismus (HP:0000211)2.63026257
50Abnormality of DNA repair (HP:0003254)2.62339338
51Generalized hypotonia (HP:0001290)2.62125597
52Premature graying of hair (HP:0002216)2.57962485
53Chromsome breakage (HP:0040012)2.57795107
54Absent thumb (HP:0009777)2.57495469
55Abnormality of the ileum (HP:0001549)2.57008908
56Severe muscular hypotonia (HP:0006829)2.55876222
57Myelodysplasia (HP:0002863)2.53636606
58Thrombocytosis (HP:0001894)2.53507263
59Abnormal trabecular bone morphology (HP:0100671)2.51535693
60Cerebral edema (HP:0002181)2.49756098
61Increased serum pyruvate (HP:0003542)2.49645612
62Impulsivity (HP:0100710)2.49568741
63Abnormality of chromosome stability (HP:0003220)2.49392035
64Neoplasm of the pancreas (HP:0002894)2.46519171
65Medulloblastoma (HP:0002885)2.43803598
66Hepatocellular necrosis (HP:0001404)2.40606868
67Secondary amenorrhea (HP:0000869)2.39002851
68Chromosomal breakage induced by crosslinking agents (HP:0003221)2.35988199
69Progressive muscle weakness (HP:0003323)2.34708310
70Premature ovarian failure (HP:0008209)2.31066891
71Horseshoe kidney (HP:0000085)2.29865652
72Severe global developmental delay (HP:0011344)2.29686047
73Absent radius (HP:0003974)2.27206454
74Bone marrow hypocellularity (HP:0005528)2.26736580
75Non-midline cleft lip (HP:0100335)2.25779382
76Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.25381776
77Agnosia (HP:0010524)2.24909420
78Renal Fanconi syndrome (HP:0001994)2.24583311
79Sparse eyelashes (HP:0000653)2.22260816
80Cellular immunodeficiency (HP:0005374)2.22251028
813-Methylglutaconic aciduria (HP:0003535)2.21264203
82Congenital ichthyosiform erythroderma (HP:0007431)2.20158454
83Aplasia/Hypoplasia of the uvula (HP:0010293)2.19888819
84CNS hypomyelination (HP:0003429)2.17249686
85Lissencephaly (HP:0001339)2.16849311
86Increased serum lactate (HP:0002151)2.15449746
87Methylmalonic acidemia (HP:0002912)2.13389411
88Fragile nails (HP:0001808)2.09573565
89Pancytopenia (HP:0001876)2.09443315
90Abnormality of methionine metabolism (HP:0010901)2.09306158
91Hepatic necrosis (HP:0002605)2.08724990
92Congenital, generalized hypertrichosis (HP:0004540)2.08432648
93Duodenal stenosis (HP:0100867)2.08264528
94Small intestinal stenosis (HP:0012848)2.08264528
95Ependymoma (HP:0002888)2.08178036
96Megaloblastic anemia (HP:0001889)2.07941139
97Entropion (HP:0000621)2.07477508
98Aplasia/Hypoplasia of the sacrum (HP:0008517)2.07449593
99Microvesicular hepatic steatosis (HP:0001414)2.06380054
100Abnormality of glycolysis (HP:0004366)2.06134258
101Aplasia involving forearm bones (HP:0009822)2.05812223
102Absent forearm bone (HP:0003953)2.05812223
103Decreased activity of mitochondrial respiratory chain (HP:0008972)2.04957287
104Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.04957287
105Cleft eyelid (HP:0000625)2.04881130
106Basal cell carcinoma (HP:0002671)2.03862683
107Supernumerary spleens (HP:0009799)2.03089992
108Megalocornea (HP:0000485)2.02034822
109Atresia of the external auditory canal (HP:0000413)2.01890498
110Decreased subcutaneous fat (HP:0001002)1.99366396
111Intellectual disability, profound (HP:0002187)1.99187292
112Squamous cell carcinoma (HP:0002860)1.99111164
113Abnormal number of incisors (HP:0011064)1.97760546
114Rhabdomyosarcoma (HP:0002859)1.97569597
115Erythroderma (HP:0001019)1.96352754
116Abnormality of the labia minora (HP:0012880)1.95971424
117Slender long bone (HP:0003100)1.95799487
118Sloping forehead (HP:0000340)1.95537375
119Type I transferrin isoform profile (HP:0003642)1.95462338
120Atrophy/Degeneration involving motor neurons (HP:0007373)1.94906329
121Prominent metopic ridge (HP:0005487)1.94445198
122Triphalangeal thumb (HP:0001199)1.94315200
123Meningocele (HP:0002435)1.94260317
124Abnormality of alanine metabolism (HP:0010916)1.93532664
125Hyperalaninemia (HP:0003348)1.93532664
126Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.93532664
127Tongue fasciculations (HP:0001308)1.92690203
128Aplasia/Hypoplasia involving the musculature (HP:0001460)1.91738972
129Tracheoesophageal fistula (HP:0002575)1.91245653
130Respiratory failure (HP:0002878)1.90617447
131Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.90291018
132Lactic acidosis (HP:0003128)1.89975521
133Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.88927724
134Abnormal lung lobation (HP:0002101)1.88702419
135Leukodystrophy (HP:0002415)1.88238225
136Abnormality of the umbilical cord (HP:0010881)1.87713649
137Brittle hair (HP:0002299)1.87554507
138Reduced antithrombin III activity (HP:0001976)1.87011936
139Abnormal spermatogenesis (HP:0008669)1.86068715
140Postnatal microcephaly (HP:0005484)1.84671260
141Exertional dyspnea (HP:0002875)1.81001609
142Hypoplasia of the radius (HP:0002984)1.80989977
143Lymphoma (HP:0002665)1.80941690
144Hypoplasia of the capital femoral epiphysis (HP:0003090)1.80565238
145Absent epiphyses (HP:0010577)1.80437480
146Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.80437480
147Exercise intolerance (HP:0003546)1.80012696
148Abnormality of serum amino acid levels (HP:0003112)1.79313897
149Amaurosis fugax (HP:0100576)1.79004359
150Proximal placement of thumb (HP:0009623)1.78034377
151Muscle fiber atrophy (HP:0100295)1.77611819
152Poor head control (HP:0002421)1.77611642
153CNS demyelination (HP:0007305)1.77470184
154Short thumb (HP:0009778)1.76800652
155Facial hemangioma (HP:0000329)1.76758722
156Neoplasm of the colon (HP:0100273)1.76104138
157Abnormal protein glycosylation (HP:0012346)1.75637141
158Abnormal glycosylation (HP:0012345)1.75637141
159Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.75637141
160Abnormal protein N-linked glycosylation (HP:0012347)1.75637141
161Abnormality of the duodenum (HP:0002246)1.74463637
162Stenosis of the external auditory canal (HP:0000402)1.74364412
163Increased intramyocellular lipid droplets (HP:0012240)1.74122317
164IgM deficiency (HP:0002850)1.74107414
165Congenital glaucoma (HP:0001087)1.73994879

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.57969102
2WEE14.45883666
3CDC73.68421692
4EIF2AK13.61270710
5NME23.40933407
6VRK23.08321123
7STK162.99070590
8SRPK12.86520721
9ACVR1B2.54059728
10EIF2AK32.51543097
11TSSK62.40910015
12BRSK22.22871976
13NEK22.21721533
14MKNK12.16674399
15PLK42.01085750
16VRK11.88995065
17DYRK31.88860769
18PLK11.87703115
19TTK1.85486149
20TLK11.83620571
21MKNK21.77365151
22PASK1.75598655
23NEK11.70520757
24TESK21.69927691
25CDK71.69539828
26NUAK11.68738646
27RPS6KA41.64804852
28AURKB1.62453771
29PIM21.61548713
30TAF11.52594752
31PLK31.51839365
32TGFBR11.51093991
33RPS6KB21.45494636
34ATR1.41625887
35AURKA1.33060305
36TRIM281.29808656
37BRSK11.28100909
38TXK1.25794026
39CHEK21.22373555
40SCYL21.21671692
41EPHA21.16295595
42MAP3K121.12937971
43BMPR1B1.11174963
44MAP3K81.09578785
45CLK11.09138796
46CDK41.08487226
47TNIK1.06231565
48CHEK11.04887738
49CCNB11.04400809
50NME10.96868044
51PAK40.92276032
52CDK80.88058382
53PIM10.87148019
54EIF2AK20.84739160
55ZAK0.84491908
56WNK30.83667555
57STK110.82598310
58CSNK2A20.80633340
59EEF2K0.80300213
60CSNK2A10.75805392
61FLT30.75392018
62PTK2B0.73437811
63ERBB40.71576872
64MAP4K20.71109558
65MAP3K110.70811351
66STK100.70733054
67PBK0.70327709
68CDK20.70138999
69MAP3K30.69920100
70ATM0.69116080
71BCKDK0.67320250
72KDR0.66565138
73MAP2K30.64859708
74MELK0.62538198
75PAK10.59702523
76ERBB30.57480047
77MAP4K10.57260976
78PDK20.56759163
79CDK120.56672921
80STK40.55396453
81BRAF0.54891988
82RPS6KA50.54068393
83ALK0.51237756
84TEC0.50698495
85ZAP700.50472695
86CSNK1G20.50196080
87PRKCI0.49750253
88TESK10.49012443
89CDK10.48785097
90DYRK20.48238781
91MAPKAPK30.47820214
92LRRK20.46316062
93CDK60.44822666
94INSRR0.43585003
95LATS10.43335401
96TAOK20.43046546
97CSNK1A1L0.42347342
98STK38L0.40567345
99BTK0.39271730
100RAF10.38438043
101BCR0.38316547
102KIT0.36346755
103PLK20.35909824
104CSNK1E0.34012674
105CDK30.31766163
106PNCK0.31051296
107STK30.30516034
108CSNK1G30.30335387
109ILK0.29356898
110AKT20.27501666
111LMTK20.27361758
112ABL20.27134576
113MAP3K50.26772149
114MST40.26657311
115BRD40.25408907
116CDK190.24844774
117BLK0.24702357
118STK390.24593673
119NEK90.24226310
120JAK30.23289680
121MAP2K70.22688607
122GRK10.22338879
123NLK0.21932279
124OXSR10.21271804
125CSNK1G10.20546000
126LYN0.20421223
127MARK30.20064550
128WNK40.20033115
129CSNK1A10.19910925
130PRKDC0.19381709
131STK240.19143647

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.73978990
2Ribosome_Homo sapiens_hsa030104.16589972
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.12356344
4Mismatch repair_Homo sapiens_hsa034303.98132082
5Proteasome_Homo sapiens_hsa030503.86342918
6RNA polymerase_Homo sapiens_hsa030203.75015420
7Spliceosome_Homo sapiens_hsa030403.43195230
8RNA transport_Homo sapiens_hsa030133.24261944
9Nucleotide excision repair_Homo sapiens_hsa034202.83218531
10Base excision repair_Homo sapiens_hsa034102.82503174
11Homologous recombination_Homo sapiens_hsa034402.80311223
12Pyrimidine metabolism_Homo sapiens_hsa002402.71279069
13One carbon pool by folate_Homo sapiens_hsa006702.57999318
14Cell cycle_Homo sapiens_hsa041102.49142139
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.45495295
16Basal transcription factors_Homo sapiens_hsa030221.97045393
17Fanconi anemia pathway_Homo sapiens_hsa034601.92160398
18RNA degradation_Homo sapiens_hsa030181.90011978
19Non-homologous end-joining_Homo sapiens_hsa034501.71334316
20Alzheimers disease_Homo sapiens_hsa050101.68195293
21mRNA surveillance pathway_Homo sapiens_hsa030151.56659166
22Purine metabolism_Homo sapiens_hsa002301.48136806
23p53 signaling pathway_Homo sapiens_hsa041151.45105343
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31428651
25Protein export_Homo sapiens_hsa030601.23833909
26Epstein-Barr virus infection_Homo sapiens_hsa051691.19675714
27SNARE interactions in vesicular transport_Homo sapiens_hsa041301.10727063
28Folate biosynthesis_Homo sapiens_hsa007901.09583230
29Vitamin B6 metabolism_Homo sapiens_hsa007501.09532442
30Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.07567874
31Systemic lupus erythematosus_Homo sapiens_hsa053221.07062897
32Cysteine and methionine metabolism_Homo sapiens_hsa002701.03531080
33Sulfur relay system_Homo sapiens_hsa041220.99624097
34Pentose phosphate pathway_Homo sapiens_hsa000300.96843512
35Pyruvate metabolism_Homo sapiens_hsa006200.96724721
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.95607233
37Propanoate metabolism_Homo sapiens_hsa006400.95144014
38Cardiac muscle contraction_Homo sapiens_hsa042600.94295012
39Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.93982213
40Antigen processing and presentation_Homo sapiens_hsa046120.92144558
41Biosynthesis of amino acids_Homo sapiens_hsa012300.87716908
42Sulfur metabolism_Homo sapiens_hsa009200.85397718
43Cyanoamino acid metabolism_Homo sapiens_hsa004600.83945003
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.83647682
45Herpes simplex infection_Homo sapiens_hsa051680.83350421
46Selenocompound metabolism_Homo sapiens_hsa004500.82967282
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.82335165
48Viral carcinogenesis_Homo sapiens_hsa052030.77880042
49Oocyte meiosis_Homo sapiens_hsa041140.73300512
50Huntingtons disease_Homo sapiens_hsa050160.65134760
51Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.64392665
52Steroid biosynthesis_Homo sapiens_hsa001000.62680513
53Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.61384316
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60100226
55Parkinsons disease_Homo sapiens_hsa050120.57647275
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57533882
57Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.56859540
58Thyroid cancer_Homo sapiens_hsa052160.56684416
59Glutathione metabolism_Homo sapiens_hsa004800.56066484
60HTLV-I infection_Homo sapiens_hsa051660.55470839
61Legionellosis_Homo sapiens_hsa051340.54650899
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53571325
63Fatty acid elongation_Homo sapiens_hsa000620.50113184
64Carbon metabolism_Homo sapiens_hsa012000.49693359
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.49073090
66Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47399913
67N-Glycan biosynthesis_Homo sapiens_hsa005100.45141214
68Peroxisome_Homo sapiens_hsa041460.42002524
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41007915
70Fructose and mannose metabolism_Homo sapiens_hsa000510.37950301
71Oxidative phosphorylation_Homo sapiens_hsa001900.37845106
72Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.37258536
73Primary immunodeficiency_Homo sapiens_hsa053400.36645841
74Small cell lung cancer_Homo sapiens_hsa052220.33844131
752-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.33113364
76Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.32981563
77Metabolic pathways_Homo sapiens_hsa011000.32809154
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.32492143
79TGF-beta signaling pathway_Homo sapiens_hsa043500.28998172
80MicroRNAs in cancer_Homo sapiens_hsa052060.28900508
81Regulation of autophagy_Homo sapiens_hsa041400.28709893
82Apoptosis_Homo sapiens_hsa042100.28499893
83Galactose metabolism_Homo sapiens_hsa000520.28067313
84Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26950910
85Alcoholism_Homo sapiens_hsa050340.26781907
86Collecting duct acid secretion_Homo sapiens_hsa049660.25496028
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24983090
88Measles_Homo sapiens_hsa051620.24439633
89Fatty acid metabolism_Homo sapiens_hsa012120.23426942
90Hepatitis B_Homo sapiens_hsa051610.23077148
91Phototransduction_Homo sapiens_hsa047440.22930235
92Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22761469
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.21913998
94Fatty acid degradation_Homo sapiens_hsa000710.19821256
95Shigellosis_Homo sapiens_hsa051310.19458435
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.19217790
97Arachidonic acid metabolism_Homo sapiens_hsa005900.16748377
98Hematopoietic cell lineage_Homo sapiens_hsa046400.16610712
99Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16308394
100Butanoate metabolism_Homo sapiens_hsa006500.15816342
101Colorectal cancer_Homo sapiens_hsa052100.15700649
102Arginine and proline metabolism_Homo sapiens_hsa003300.15098965
103Vitamin digestion and absorption_Homo sapiens_hsa049770.15062320
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.14502261
105Renin-angiotensin system_Homo sapiens_hsa046140.14445614
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.13916324
107RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.13318236
108Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.12946103
109Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.12823532
110Asthma_Homo sapiens_hsa053100.12810669
111Hippo signaling pathway_Homo sapiens_hsa043900.11524202
112Bladder cancer_Homo sapiens_hsa052190.11339948
113Allograft rejection_Homo sapiens_hsa053300.10895820
114HIF-1 signaling pathway_Homo sapiens_hsa040660.09509161
115Influenza A_Homo sapiens_hsa051640.08544600
116Intestinal immune network for IgA production_Homo sapiens_hsa046720.08471395
117Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.05757996
118Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.05573626
119Autoimmune thyroid disease_Homo sapiens_hsa053200.05493444
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.05081323
121Pathways in cancer_Homo sapiens_hsa052000.05064506
122Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.04819910
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.04703531
124Chemical carcinogenesis_Homo sapiens_hsa052040.04625325
125Caffeine metabolism_Homo sapiens_hsa002320.04390436
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.03458670
127Tryptophan metabolism_Homo sapiens_hsa003800.03152752
128Graft-versus-host disease_Homo sapiens_hsa053320.01875782

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