NIFKP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)9.57633983
2leukocyte aggregation (GO:0070486)8.46187626
3thrombin receptor signaling pathway (GO:0070493)8.29256726
4positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)6.16780583
5glycoprotein catabolic process (GO:0006516)6.09528372
6rRNA transcription (GO:0009303)5.57022050
7regulation of integrin-mediated signaling pathway (GO:2001044)5.46123836
8neutrophil activation involved in immune response (GO:0002283)5.25901488
9adenosine receptor signaling pathway (GO:0001973)4.95438587
10G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.94946711
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.82810167
12negative regulation of norepinephrine secretion (GO:0010700)4.81658003
13SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0031146)4.72097504
14positive regulation of signal transduction by p53 class mediator (GO:1901798)4.68499371
15regulation of platelet activation (GO:0010543)4.38068686
16blood coagulation, intrinsic pathway (GO:0007597)4.27199958
17purinergic nucleotide receptor signaling pathway (GO:0035590)4.26383121
18erythrocyte maturation (GO:0043249)4.23741668
19regulation of female receptivity (GO:0045924)4.16963591
20nucleotide-binding oligomerization domain containing signaling pathway (GO:0070423)4.10828945
21negative regulation of heart rate (GO:0010459)4.06626181
22regulation of platelet aggregation (GO:0090330)4.06264213
23homotypic cell-cell adhesion (GO:0034109)4.04634238
24myelin assembly (GO:0032288)4.04288574
25leukocyte migration involved in inflammatory response (GO:0002523)4.02607226
26platelet aggregation (GO:0070527)4.00394856
27positive regulation of systemic arterial blood pressure (GO:0003084)3.99363579
28positive regulation of vascular permeability (GO:0043117)3.98985982
29regulation of regulatory T cell differentiation (GO:0045589)3.86462428
30negative regulation of platelet activation (GO:0010544)3.80594888
31female mating behavior (GO:0060180)3.77617285
32negative regulation of appetite (GO:0032099)3.76619627
33negative regulation of response to food (GO:0032096)3.76619627
34regulation of lipoprotein metabolic process (GO:0050746)3.73491288
35induction of positive chemotaxis (GO:0050930)3.72889809
36positive regulation of endothelial cell differentiation (GO:0045603)3.69109697
37negative regulation of protein localization to cell surface (GO:2000009)3.61655388
38reciprocal meiotic recombination (GO:0007131)3.61167260
39reciprocal DNA recombination (GO:0035825)3.61167260
40meiotic chromosome segregation (GO:0045132)3.60166701
41cytoplasmic pattern recognition receptor signaling pathway (GO:0002753)3.55260785
42G-protein coupled purinergic receptor signaling pathway (GO:0035588)3.54719621
43low-density lipoprotein particle remodeling (GO:0034374)3.51970311
44positive regulation of amino acid transport (GO:0051957)3.51420075
45purinergic receptor signaling pathway (GO:0035587)3.50039292
46purine nucleotide salvage (GO:0032261)3.38629422
47platelet degranulation (GO:0002576)3.37337669
48positive regulation of defense response to virus by host (GO:0002230)3.36166218
49positive regulation of monocyte chemotaxis (GO:0090026)3.31842865
50regulation of glutamate secretion (GO:0014048)3.27913773
51positive regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030949)3.26578236
52neutrophil activation (GO:0042119)3.24423531
53negative regulation of macrophage derived foam cell differentiation (GO:0010745)3.24185846
54regulation of norepinephrine secretion (GO:0014061)3.22635269
55macroautophagy (GO:0016236)3.21214114
56membrane invagination (GO:0010324)3.20327767
57negative regulation of homotypic cell-cell adhesion (GO:0034111)3.20130539
58positive regulation of mast cell activation (GO:0033005)3.18069686
59lipoxygenase pathway (GO:0019372)3.15826439
60beta-amyloid metabolic process (GO:0050435)3.12197731
61synaptonemal complex assembly (GO:0007130)3.10859968
62negative regulation of catecholamine secretion (GO:0033604)3.10025778
63sequestering of actin monomers (GO:0042989)3.08649040
64negative regulation of focal adhesion assembly (GO:0051895)3.08011503
65negative regulation of cell junction assembly (GO:1901889)3.08011503
66negative regulation of adherens junction organization (GO:1903392)3.08011503
67fusion of sperm to egg plasma membrane (GO:0007342)3.07922838
68regulation of Golgi to plasma membrane protein transport (GO:0042996)3.01555347
69I-kappaB kinase/NF-kappaB signaling (GO:0007249)3.01326415
70negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.00783186
71autophagic vacuole fusion (GO:0000046)2.99718222
72hematopoietic stem cell differentiation (GO:0060218)2.98499802
73negative regulation of thymocyte apoptotic process (GO:0070244)2.98380359
74purine-containing compound salvage (GO:0043101)2.96479508
75regulation of immunoglobulin secretion (GO:0051023)2.96130996
76negative regulation of interleukin-17 production (GO:0032700)2.94749192
77pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.92431571
78regulation of transmission of nerve impulse (GO:0051969)2.91638195
79platelet activation (GO:0030168)2.87818224
80megakaryocyte development (GO:0035855)2.86772031
81positive regulation of cAMP-mediated signaling (GO:0043950)2.86460952
82UV protection (GO:0009650)2.86207565
83granulocyte activation (GO:0036230)2.86082904
84positive regulation of Rho protein signal transduction (GO:0035025)2.85359049
85angiogenesis involved in wound healing (GO:0060055)2.82142804
86synaptonemal complex organization (GO:0070193)2.81711515
87pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.80325620
88regulation of lymphocyte migration (GO:2000401)2.77888321
89positive regulation of immunoglobulin mediated immune response (GO:0002891)2.77409232
90positive regulation of B cell mediated immunity (GO:0002714)2.77409232
91DNA deamination (GO:0045006)2.77209572
92pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.73601310
93negative regulation of heart contraction (GO:0045822)2.73378610
94neuronal action potential propagation (GO:0019227)2.72533121
95positive regulation of isotype switching (GO:0045830)2.72285778
96forebrain morphogenesis (GO:0048853)2.71945679
97deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.71233530
98innate immune response in mucosa (GO:0002227)2.69961377
99platelet formation (GO:0030220)2.69593665
100activation of MAPKKK activity (GO:0000185)10.7528657

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1LYL1_20887958_ChIP-Seq_HPC-7_Mouse4.87787297
2SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human4.35118985
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.80688709
4EZH2_22144423_ChIP-Seq_EOC_Human3.73147885
5RUNX1_20887958_ChIP-Seq_HPC-7_Mouse3.57992241
6STAT6_21828071_ChIP-Seq_BEAS2B_Human3.25651291
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.20193530
8LMO2_20887958_ChIP-Seq_HPC-7_Mouse3.04513333
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.68247020
10GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human2.62513153
11STAT1_20625510_ChIP-Seq_HELA_Human2.60465456
12GATA1_19941826_ChIP-Seq_K562_Human2.48493184
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.41080328
14GATA2_20887958_ChIP-Seq_HPC-7_Mouse2.12640920
15GATA2_19941826_ChIP-Seq_K562_Human2.09593329
16GBX2_23144817_ChIP-Seq_PC3_Human2.07577042
17PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.07152443
18SCL_19346495_ChIP-Seq_HPC-7_Human2.05502731
19SRY_22984422_ChIP-ChIP_TESTIS_Rat2.01414537
20GATA1_19941827_ChIP-Seq_MEL_Mouse1.92047077
21HTT_18923047_ChIP-ChIP_STHdh_Human1.79178042
22SPI1_23127762_ChIP-Seq_K562_Human1.73035451
23SPI1_20517297_ChIP-Seq_HL60_Human1.71886732
24IKZF1_21737484_ChIP-ChIP_HCT116_Human1.69079467
25IRF8_21731497_ChIP-ChIP_J774_Mouse1.67885041
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.66224153
27TAF15_26573619_Chip-Seq_HEK293_Human1.57023495
28MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.52999941
29GATA1_22383799_ChIP-Seq_G1ME_Mouse1.50339446
30TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47604119
31ELF1_20517297_ChIP-Seq_JURKAT_Human1.39580925
32GATA3_21878914_ChIP-Seq_MCF-7_Human1.39549755
33BP1_19119308_ChIP-ChIP_Hs578T_Human1.39088992
34RUNX_20019798_ChIP-Seq_JUKART_Human1.38862101
35AR_20517297_ChIP-Seq_VCAP_Human1.38456539
36FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.36129992
37TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.34509513
38THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.33924053
39TP53_22573176_ChIP-Seq_HFKS_Human1.33279421
40TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.32943795
41P53_22127205_ChIP-Seq_FIBROBLAST_Human1.28542507
42ELK4_26923725_Chip-Seq_MESODERM_Mouse1.27093858
43GATA1_19941827_ChIP-Seq_MEL86_Mouse1.25920083
44IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.25824206
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.23571031
46FLI1_27457419_Chip-Seq_LIVER_Mouse1.20530627
47PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.20433029
48VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.16735850
49FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.15675684
50SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14783525
51FOXA1_27270436_Chip-Seq_PROSTATE_Human1.14510123
52FOXA1_25329375_ChIP-Seq_VCAP_Human1.14510123
53VDR_22108803_ChIP-Seq_LS180_Human1.13917992
54ERG_20517297_ChIP-Seq_VCAP_Human1.12780950
55PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12552334
56EWS_26573619_Chip-Seq_HEK293_Human1.11992398
57TAF2_19829295_ChIP-Seq_ESCs_Human1.09690424
58RUNX1_22412390_ChIP-Seq_EML_Mouse1.09193654
59IRF8_22096565_ChIP-ChIP_GC-B_Human1.07910306
60STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.07769962
61PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06966725
62HNFA_21074721_ChIP-Seq_CACO-2_Human1.06644018
63MYB_26560356_Chip-Seq_TH2_Human1.05234910
64NANOG_20526341_ChIP-Seq_ESCs_Human1.05196100
65GATA2_21666600_ChIP-Seq_HMVEC_Human1.04500524
66YY1_22570637_ChIP-Seq_MALME-3M_Human1.03029274
67MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02834778
68CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.02353023
69RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01583848
70GATA6_21074721_ChIP-Seq_CACO-2_Human1.01536664
71RBPJ_21746931_ChIP-Seq_IB4_Human1.01043632
72CRX_20693478_ChIP-Seq_RETINA_Mouse1.00920933
73FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00829504
74SPI1_23547873_ChIP-Seq_NB4_Human0.99863043
75LMO2_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.98805799
76NFE2_27457419_Chip-Seq_LIVER_Mouse0.98793987
77NANOG_19829295_ChIP-Seq_ESCs_Human0.98696604
78SOX2_19829295_ChIP-Seq_ESCs_Human0.98696604
79PHF8_20622853_ChIP-Seq_HELA_Human0.98550745
80IRF8_27001747_Chip-Seq_BMDM_Mouse0.97980873
81GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.97933568
82FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97230432
83UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.97181915
84Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.96718256
85SOX2_21211035_ChIP-Seq_LN229_Human0.95976004
86EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.95772522
87SMRT_27268052_Chip-Seq_Bcells_Human0.95179687
88CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94613859
89CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94012888
90CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.92980763
91CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.92740539
92FOXA1_21572438_ChIP-Seq_LNCaP_Human0.92251462
93GATA3_27048872_Chip-Seq_THYMUS_Human0.92099762
94GATA2_22383799_ChIP-Seq_G1ME_Mouse0.91336124
95GATA3_26560356_Chip-Seq_TH2_Human0.90597892
96AR_25329375_ChIP-Seq_VCAP_Human0.90176389
97ERG_20887958_ChIP-Seq_HPC-7_Mouse0.90174469
98EZH2_27294783_Chip-Seq_NPCs_Mouse0.88062028
99TP53_16413492_ChIP-PET_HCT116_Human0.87459996
100OCT1_27270436_Chip-Seq_PROSTATE_Human0.86342504

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005623_abnormal_meninges_morphology8.43649368
2MP0005464_abnormal_platelet_physiology7.32911220
3MP0008004_abnormal_stomach_pH3.73947724
4MP0000013_abnormal_adipose_tissue3.12941210
5MP0009384_cardiac_valve_regurgitation3.04014861
6MP0005671_abnormal_response_to2.93116887
7MP0000750_abnormal_muscle_regeneration2.80426428
8MP0005083_abnormal_biliary_tract2.78801499
9MP0000858_altered_metastatic_potential2.72587709
10MP0000343_altered_response_to2.58728781
11MP0003724_increased_susceptibility_to2.43244100
12MP0004947_skin_inflammation2.20447196
13MP0008775_abnormal_heart_ventricle2.15716434
14MP0004130_abnormal_muscle_cell2.10516378
15MP0001835_abnormal_antigen_presentation2.05706698
16MP0005410_abnormal_fertilization2.00818191
17MP0002736_abnormal_nociception_after1.85269234
18MP0000465_gastrointestinal_hemorrhage1.81644349
19MP0002638_abnormal_pupillary_reflex1.71608954
20MP0000230_abnormal_systemic_arterial1.60354752
21MP0003786_premature_aging1.60183540
22MP0008872_abnormal_physiological_respon1.58276707
23MP0005646_abnormal_pituitary_gland1.52553864
24MP0005084_abnormal_gallbladder_morpholo1.43569608
25MP0004147_increased_porphyrin_level1.42552027
26MP0003638_abnormal_response/metabolism_1.39482610
27MP0010155_abnormal_intestine_physiology1.30080778
28MP0005000_abnormal_immune_tolerance1.27993513
29MP0002938_white_spotting1.26238068
30MP0004084_abnormal_cardiac_muscle1.25343895
31MP0009764_decreased_sensitivity_to1.24617678
32MP0004215_abnormal_myocardial_fiber1.19163930
33MP0009765_abnormal_xenobiotic_induced1.18402008
34MP0004510_myositis1.18027778
35MP0003279_aneurysm1.16811790
36MP0005584_abnormal_enzyme/coenzyme_acti1.16250748
37MP0002148_abnormal_hypersensitivity_rea1.15757913
38MP0002102_abnormal_ear_morphology1.11463099
39MP0001800_abnormal_humoral_immune1.07277964
40MP0001663_abnormal_digestive_system1.06315867
41MP0001968_abnormal_touch/_nociception1.06098993
42MP0005551_abnormal_eye_electrophysiolog1.05823811
43MP0002723_abnormal_immune_serum1.05518180
44MP0009379_abnormal_foot_pigmentation1.05509143
45MP0009763_increased_sensitivity_to1.04945183
46MP0003828_pulmonary_edema1.04699976
47MP0001879_abnormal_lymphatic_vessel1.01665391
48MP0002735_abnormal_chemical_nociception1.00800913
49MP0003763_abnormal_thymus_physiology0.99334769
50MP0002132_abnormal_respiratory_system0.97900076
51MP0004036_abnormal_muscle_relaxation0.97161582
52MP0009333_abnormal_splenocyte_physiolog0.97041727
53MP0003879_abnormal_hair_cell0.96622799
54MP0002733_abnormal_thermal_nociception0.94970284
55MP0000685_abnormal_immune_system0.93419710
56MP0002452_abnormal_antigen_presenting0.93044713
57MP0002177_abnormal_outer_ear0.92482530
58MP0002398_abnormal_bone_marrow0.92104615
59MP0003866_abnormal_defecation0.91426870
60MP0005645_abnormal_hypothalamus_physiol0.91230484
61MP0006054_spinal_hemorrhage0.90633489
62MP0003303_peritoneal_inflammation0.90597723
63MP0000689_abnormal_spleen_morphology0.90458926
64MP0002420_abnormal_adaptive_immunity0.89927900
65MP0008874_decreased_physiological_sensi0.89712615
66MP0005501_abnormal_skin_physiology0.89556327
67MP0000249_abnormal_blood_vessel0.89276059
68MP0006276_abnormal_autonomic_nervous0.87351384
69MP0001819_abnormal_immune_cell0.86430742
70MP0001545_abnormal_hematopoietic_system0.85382492
71MP0005397_hematopoietic_system_phenotyp0.85382492
72MP0005025_abnormal_response_to0.80727997
73MP0000003_abnormal_adipose_tissue0.80367961
74MP0002128_abnormal_blood_circulation0.78553121
75MP0002067_abnormal_sensory_capabilities0.77271796
76MP0005387_immune_system_phenotype0.76369459
77MP0001790_abnormal_immune_system0.76369459
78MP0005167_abnormal_blood-brain_barrier0.74719896
79MP0002019_abnormal_tumor_incidence0.74107362
80MP0009642_abnormal_blood_homeostasis0.73566095
81MP0002722_abnormal_immune_system0.70956754
82MP0002429_abnormal_blood_cell0.70838507
83MP0002972_abnormal_cardiac_muscle0.70747843
84MP0003137_abnormal_impulse_conducting0.70633067
85MP0006292_abnormal_olfactory_placode0.69725947
86MP0001905_abnormal_dopamine_level0.68153001
87MP0004087_abnormal_muscle_fiber0.67919098
88MP0010329_abnormal_lipoprotein_level0.67809879
89MP0005385_cardiovascular_system_phenoty0.67181347
90MP0001544_abnormal_cardiovascular_syste0.67181347
91MP0005381_digestive/alimentary_phenotyp0.66004269
92MP0001851_eye_inflammation0.65946854
93MP0002234_abnormal_pharynx_morphology0.65615351
94MP0005375_adipose_tissue_phenotype0.64142964
95MP0000762_abnormal_tongue_morphology0.63346225
96MP0005058_abnormal_lysosome_morphology0.62441072
97MP0008873_increased_physiological_sensi0.62144231
98MP0003385_abnormal_body_wall0.61249721
99MP0000716_abnormal_immune_system0.61101506
100MP0003186_abnormal_redox_activity0.60025414

Predicted human phenotypes

RankGene SetZ-score
1Retinal atrophy (HP:0001105)9.60780279
2Cerebellar dysplasia (HP:0007033)8.78189774
3Type II lissencephaly (HP:0007260)7.53807125
4Fatigue (HP:0012378)7.45527807
5Hypoplasia of the pons (HP:0012110)6.87945976
6Retinal dysplasia (HP:0007973)6.68684719
7Prolonged bleeding time (HP:0003010)6.53270024
8Abnormality of the pons (HP:0007361)6.16097926
9Aplasia/Hypoplasia affecting the retina (HP:0008061)5.98680679
10Difficulty climbing stairs (HP:0003551)5.81588298
11Menorrhagia (HP:0000132)5.81171351
12Decreased electroretinogram (ERG) amplitude (HP:0000654)5.74253606
13Petechiae (HP:0000967)5.64341930
14Increased mean platelet volume (HP:0011877)5.54162906
15Buphthalmos (HP:0000557)5.51617084
16Abnormal platelet volume (HP:0011876)5.19008663
17Abolished electroretinogram (ERG) (HP:0000550)4.98695121
18Purpura (HP:0000979)4.95755143
19Epistaxis (HP:0000421)4.69496617
20Increased IgM level (HP:0003496)4.62313816
21Acanthocytosis (HP:0001927)3.96815647
22Gingival bleeding (HP:0000225)3.82210250
23Abnormal platelet function (HP:0011869)3.70245283
24Impaired platelet aggregation (HP:0003540)3.70245283
25Hyperlipoproteinemia (HP:0010980)3.49018252
26Spontaneous hematomas (HP:0007420)3.41740053
27IgG deficiency (HP:0004315)3.29666980
28Congenital glaucoma (HP:0001087)3.16282807
29Entropion (HP:0000621)3.14530596
30Poikilocytosis (HP:0004447)3.10975837
31Severe muscular hypotonia (HP:0006829)3.07896783
32Intellectual disability, profound (HP:0002187)3.04988721
33Conjunctival telangiectasia (HP:0000524)3.03798308
34Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.96491359
35Generalized hypotonia (HP:0001290)2.90923785
36Dyschromatopsia (HP:0007641)2.88830996
37Gowers sign (HP:0003391)2.75816988
38Abnormality of the common coagulation pathway (HP:0010990)2.66178268
39Megalocornea (HP:0000485)2.65684676
40Lissencephaly (HP:0001339)2.63674953
41Abnormality of the vasculature of the conjunctiva (HP:0008054)2.58571387
42Generalized muscle weakness (HP:0003324)2.57839491
43Paralysis (HP:0003470)2.55116239
44Severe global developmental delay (HP:0011344)2.54034180
45Abnormality of the heme biosynthetic pathway (HP:0010472)2.51053602
46Poikiloderma (HP:0001029)2.43656982
47Aplasia/Hypoplasia affecting the fundus (HP:0008057)2.39829907
48Stomatitis (HP:0010280)2.39504769
49Abnormality of vision evoked potentials (HP:0000649)2.37156859
50Decreased central vision (HP:0007663)2.31392557
51Hypoplasia of the brainstem (HP:0002365)2.31163965
52Aplasia/Hypoplasia of the brainstem (HP:0007362)2.31163965
53Papilledema (HP:0001085)2.25026925
54Abnormality of DNA repair (HP:0003254)2.24440376
55Pachygyria (HP:0001302)2.23959589
56Abnormal pupillary function (HP:0007686)2.11571987
57Eosinophilia (HP:0001880)2.09986298
58Mesangial abnormality (HP:0001966)2.06016018
59Submucous cleft hard palate (HP:0000176)2.01692858
60IgA deficiency (HP:0002720)2.01497592
61Encephalitis (HP:0002383)1.95457003
62Tinnitus (HP:0000360)1.94067240
63Fragile nails (HP:0001808)1.92091421
64Abnormality of the vitreous humor (HP:0004327)1.91186629
65Bruising susceptibility (HP:0000978)1.90220639
66Nausea (HP:0002018)1.86968662
67Decreased subcutaneous fat (HP:0001002)1.86873839
68Ileus (HP:0002595)1.86080393
69Hepatosplenomegaly (HP:0001433)1.85846447
70Abnormality of incisor morphology (HP:0011063)1.84896979
71Meningocele (HP:0002435)1.82279083
72Abnormality of macrophages (HP:0004311)1.79735758
73Joint swelling (HP:0001386)1.79429275
743-Methylglutaconic aciduria (HP:0003535)1.77952619
75Pallor (HP:0000980)1.77232560
76Joint hemorrhage (HP:0005261)1.73871138
77Granulocytopenia (HP:0001913)1.72951744
78Male infertility (HP:0003251)1.72640888
79Muscular dystrophy (HP:0003560)1.69999312
80Hypergammaglobulinemia (HP:0010702)1.69483001
81Spontaneous abortion (HP:0005268)1.66753478
82Keratitis (HP:0000491)1.64214190
83Erythroderma (HP:0001019)1.60832363
84Abnormality of iron homeostasis (HP:0011031)1.57026293
85Muscle stiffness (HP:0003552)1.54887588
86Congenital ichthyosiform erythroderma (HP:0007431)1.52802546
87Non-midline cleft lip (HP:0100335)1.51694325
88Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.49254505
89Abnormal auditory evoked potentials (HP:0006958)1.49116233
90Abnormality of eosinophils (HP:0001879)1.44898464
91Xanthomatosis (HP:0000991)1.43922169
92Abnormality of transition element cation homeostasis (HP:0011030)1.43370388
93Increased density of long bones (HP:0006392)1.42767945
94Basal ganglia calcification (HP:0002135)1.42686398
95Infertility (HP:0000789)1.41640988
96Leukocytosis (HP:0001974)1.39233788
97Death in childhood (HP:0003819)1.37871755
98Acute necrotizing encephalopathy (HP:0006965)1.35701589
99Supranuclear gaze palsy (HP:0000605)1.34627321
100Slow saccadic eye movements (HP:0000514)1.34376623

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK37.31902616
2STK106.76881368
3PTK2B3.80118337
4MST43.09358200
5RIPK42.86876803
6LMTK22.78539505
7PIM12.58013206
8TXK2.43942385
9BMX2.41008959
10TEC2.20149592
11MYLK2.15513837
12BTK2.00004057
13STK111.98362959
14CSF1R1.83665281
15PIK3CG1.57767210
16NLK1.57365198
17TESK21.47619296
18EIF2AK11.43648402
19ZAP701.39342844
20ADRBK21.38401325
21TAOK21.32123299
22SYK1.31058726
23TLK11.26737699
24IKBKB1.22776929
25GRK51.21636606
26EPHA31.20725048
27TAOK31.11445685
28BRSK21.09075198
29CAMKK21.08171623
30MAP4K11.04854565
31ILK1.03538402
32TNIK0.99309450
33GRK60.88588784
34HCK0.86360573
35MAP2K30.86239188
36BMPR20.84986270
37LYN0.80179677
38IRAK30.79554672
39IRAK10.76464086
40PKN10.76303059
41PIK3CA0.75274121
42TNK20.73967335
43PLK20.73424447
44STK30.72345283
45FRK0.69598063
46FGR0.67530398
47MAPKAPK30.63593498
48KDR0.62255145
49ITK0.61380616
50TAOK10.60834450
51MAP3K110.60108411
52DAPK30.59997565
53LCK0.59718610
54TRIM280.59391393
55MATK0.58764286
56YES10.58750947
57FER0.57817985
58MAP4K20.54350465
59PRKCH0.53631659
60MAP3K50.52638976
61FES0.52371647
62PRKD10.52297787
63GSK3A0.52292498
64ADRBK10.51585491
65ACVR1B0.47534109
66STK40.45834493
67MAP3K30.44336940
68STK240.43739797
69PRKACG0.43283536
70FYN0.42028896
71PAK10.41906658
72BMPR1B0.41278080
73CSK0.38719183
74PIM20.36919967
75PRKCE0.36484697
76PDK10.34757708
77GRK10.33782478
78IGF1R0.32513158
79VRK10.32436826
80ERBB20.32014152
81ZAK0.31967887
82MAPK110.31845879
83PRKCD0.31562579
84DAPK20.31072603
85PRKCQ0.30803864
86MELK0.28394250
87PDPK10.27540028
88TIE10.27443066
89PRKG10.27302500
90RET0.27263142
91BLK0.26698606
92CSNK1G30.26558668
93CSNK1D0.26455598
94RPS6KA50.26301838
95PRKCA0.22429250
96HIPK20.21005203
97PRKD20.21004328
98NUAK10.20919010
99DYRK1A0.20721186
100PRKG20.20483438

Predicted pathways (KEGG)

RankGene SetZ-score
1SNARE interactions in vesicular transport_Homo sapiens_hsa041305.79568625
2Platelet activation_Homo sapiens_hsa046113.63042983
3Other types of O-glycan biosynthesis_Homo sapiens_hsa005143.48621345
4NOD-like receptor signaling pathway_Homo sapiens_hsa046212.33759836
5Pathogenic Escherichia coli infection_Homo sapiens_hsa051302.18678452
6Nitrogen metabolism_Homo sapiens_hsa009102.08807834
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.06557696
8Systemic lupus erythematosus_Homo sapiens_hsa053221.95779794
9Primary immunodeficiency_Homo sapiens_hsa053401.92257816
10Mismatch repair_Homo sapiens_hsa034301.88097956
11Hematopoietic cell lineage_Homo sapiens_hsa046401.86438531
12Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.71537325
13Sulfur metabolism_Homo sapiens_hsa009201.69266379
14Toll-like receptor signaling pathway_Homo sapiens_hsa046201.56091561
15Graft-versus-host disease_Homo sapiens_hsa053321.53290341
16Alcoholism_Homo sapiens_hsa050341.52751165
17Arachidonic acid metabolism_Homo sapiens_hsa005901.48217917
18Asthma_Homo sapiens_hsa053101.46320549
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.42202780
20Chemokine signaling pathway_Homo sapiens_hsa040621.39014596
21Collecting duct acid secretion_Homo sapiens_hsa049661.37082429
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.34817750
23Allograft rejection_Homo sapiens_hsa053301.34689569
24Serotonergic synapse_Homo sapiens_hsa047261.34072863
25Leishmaniasis_Homo sapiens_hsa051401.33393146
26Autoimmune thyroid disease_Homo sapiens_hsa053201.29179034
27Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.27734287
28ECM-receptor interaction_Homo sapiens_hsa045121.26642461
29Glycosaminoglycan degradation_Homo sapiens_hsa005311.19374497
30Sulfur relay system_Homo sapiens_hsa041221.19189689
31TNF signaling pathway_Homo sapiens_hsa046681.15232389
32Regulation of autophagy_Homo sapiens_hsa041401.11974308
33Toxoplasmosis_Homo sapiens_hsa051451.10963026
34Ribosome_Homo sapiens_hsa030101.08766116
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.07756462
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.06582290
37Glycerolipid metabolism_Homo sapiens_hsa005611.03846190
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.03183454
39Olfactory transduction_Homo sapiens_hsa047401.00197970
40Osteoclast differentiation_Homo sapiens_hsa043800.96824133
41Steroid hormone biosynthesis_Homo sapiens_hsa001400.96124610
42B cell receptor signaling pathway_Homo sapiens_hsa046620.94733189
43Pancreatic secretion_Homo sapiens_hsa049720.94509343
44Phagosome_Homo sapiens_hsa041450.92536082
45Linoleic acid metabolism_Homo sapiens_hsa005910.86658403
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85921236
47Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84712074
48Gap junction_Homo sapiens_hsa045400.76364854
49Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.76319181
50Vascular smooth muscle contraction_Homo sapiens_hsa042700.74732781
51Homologous recombination_Homo sapiens_hsa034400.73461790
52Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.71550301
53Malaria_Homo sapiens_hsa051440.70203395
54Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.69823648
55Shigellosis_Homo sapiens_hsa051310.69178471
56Adipocytokine signaling pathway_Homo sapiens_hsa049200.68045126
57Rheumatoid arthritis_Homo sapiens_hsa053230.66943125
58Parkinsons disease_Homo sapiens_hsa050120.66069541
59Rap1 signaling pathway_Homo sapiens_hsa040150.65331406
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63191033
61Nucleotide excision repair_Homo sapiens_hsa034200.60674338
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.59418445
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.58313596
64Pyrimidine metabolism_Homo sapiens_hsa002400.58289148
65Oxidative phosphorylation_Homo sapiens_hsa001900.58046903
66Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57740368
67Drug metabolism - other enzymes_Homo sapiens_hsa009830.57257093
68Pancreatic cancer_Homo sapiens_hsa052120.56688053
69T cell receptor signaling pathway_Homo sapiens_hsa046600.56402584
70Endocytosis_Homo sapiens_hsa041440.52509230
71Starch and sucrose metabolism_Homo sapiens_hsa005000.51907125
72Calcium signaling pathway_Homo sapiens_hsa040200.50279175
73Ras signaling pathway_Homo sapiens_hsa040140.49940014
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.48401003
75Type I diabetes mellitus_Homo sapiens_hsa049400.48396146
76Purine metabolism_Homo sapiens_hsa002300.47902121
77Circadian entrainment_Homo sapiens_hsa047130.47662486
78Pentose phosphate pathway_Homo sapiens_hsa000300.46653949
79Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.46513271
80One carbon pool by folate_Homo sapiens_hsa006700.45800735
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.45487348
82Glutathione metabolism_Homo sapiens_hsa004800.45042645
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44133974
84Chemical carcinogenesis_Homo sapiens_hsa052040.43406831
85Fanconi anemia pathway_Homo sapiens_hsa034600.43030500
86Phospholipase D signaling pathway_Homo sapiens_hsa040720.41918075
87PPAR signaling pathway_Homo sapiens_hsa033200.41310217
88GABAergic synapse_Homo sapiens_hsa047270.40399054
89Viral myocarditis_Homo sapiens_hsa054160.39062793
90Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.38628493
91Staphylococcus aureus infection_Homo sapiens_hsa051500.37602838
92Cholinergic synapse_Homo sapiens_hsa047250.37041580
93Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.37016096
94Morphine addiction_Homo sapiens_hsa050320.35665453
95Fat digestion and absorption_Homo sapiens_hsa049750.33899630
96Gastric acid secretion_Homo sapiens_hsa049710.33687418
97Focal adhesion_Homo sapiens_hsa045100.33570115
98Antigen processing and presentation_Homo sapiens_hsa046120.33143881
99Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.33088137
100Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32991528

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