ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.84322711
2	fucose catabolic process (GO:0019317)	4.40855048
3	L-fucose metabolic process (GO:0042354)	4.40855048
4	L-fucose catabolic process (GO:0042355)	4.40855048
5	sulfation (GO:0051923)	4.25628972
6	negative regulation of telomere maintenance (GO:0032205)	4.03840883
7	water-soluble vitamin biosynthetic process (GO:0042364)	4.02402078
8	kynurenine metabolic process (GO:0070189)	3.89904892
9	cell proliferation in forebrain (GO:0021846)	3.86295634
10	response to pheromone (GO:0019236)	3.73655309
11	DNA deamination (GO:0045006)	3.73052371
12	indolalkylamine catabolic process (GO:0046218)	3.66169349
13	tryptophan catabolic process (GO:0006569)	3.66169349
14	indole-containing compound catabolic process (GO:0042436)	3.66169349
15	regulation of posttranscriptional gene silencing (GO:0060147)	3.55789787
16	regulation of gene silencing by miRNA (GO:0060964)	3.55789787
17	regulation of gene silencing by RNA (GO:0060966)	3.55789787
18	cellular response to ATP (GO:0071318)	3.54262847
19	protein polyglutamylation (GO:0018095)	3.48327337
20	indolalkylamine metabolic process (GO:0006586)	3.37231089
21	somite development (GO:0061053)	3.29776466
22	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.28656779
23	negative regulation of mast cell activation (GO:0033004)	3.26463297
24	gamma-aminobutyric acid transport (GO:0015812)	3.23711377
25	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.20012010
26	NADH dehydrogenase complex assembly (GO:0010257)	3.20012010
27	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.20012010
28	kidney morphogenesis (GO:0060993)	3.11776746
29	tryptophan metabolic process (GO:0006568)	3.09146840
30	negative regulation of transcription regulatory region DNA binding (GO:2000678)	3.04095627
31	protein complex biogenesis (GO:0070271)	3.04093296
32	regulation of mesoderm development (GO:2000380)	3.00009576
33	cornea development in camera-type eye (GO:0061303)	2.93721004
34	ATP synthesis coupled proton transport (GO:0015986)	2.92435404
35	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.92435404
36	nephron tubule morphogenesis (GO:0072078)	2.90079306
37	nephron epithelium morphogenesis (GO:0072088)	2.90079306
38	3-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)	2.89530400
39	purine ribonucleoside bisphosphate metabolic process (GO:0034035)	2.89530400
40	platelet dense granule organization (GO:0060155)	2.85964265
41	indole-containing compound metabolic process (GO:0042430)	2.85732875
42	neuronal action potential (GO:0019228)	2.85214672
43	positive regulation of cAMP-mediated signaling (GO:0043950)	2.83825875
44	regulation of memory T cell differentiation (GO:0043380)	2.82736551
45	serotonin metabolic process (GO:0042428)	2.82565839
46	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.81654198
47	primary amino compound metabolic process (GO:1901160)	2.81475984
48	negative regulation of synaptic transmission, GABAergic (GO:0032229)	2.79802166
49	regulation of action potential (GO:0098900)	2.79245422
50	negative regulation of systemic arterial blood pressure (GO:0003085)	2.77477081
51	preassembly of GPI anchor in ER membrane (GO:0016254)	2.76912313
52	mitochondrial respiratory chain complex assembly (GO:0033108)	2.76443930
53	startle response (GO:0001964)	2.73895896
54	establishment of protein localization to mitochondrial membrane (GO:0090151)	2.73600712
55	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	2.73357935
56	negative regulation of multicellular organism growth (GO:0040015)	2.73309785
57	protein-cofactor linkage (GO:0018065)	2.69989572
58	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.69751512
59	transmission of nerve impulse (GO:0019226)	2.69499338
60	detection of light stimulus involved in sensory perception (GO:0050962)	2.68359474
61	detection of light stimulus involved in visual perception (GO:0050908)	2.68359474
62	hindbrain development (GO:0030902)	2.67127880
63	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	2.64995392
64	parturition (GO:0007567)	2.62911784
65	photoreceptor cell development (GO:0042461)	2.62672927
66	regulation of glomerulus development (GO:0090192)	2.62414727
67	epithelial cilium movement (GO:0003351)	2.61807148
68	protein neddylation (GO:0045116)	2.61691756
69	reflex (GO:0060004)	2.61452467
70	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.59834043
71	peristalsis (GO:0030432)	2.59678706
72	rhodopsin mediated signaling pathway (GO:0016056)	2.55831706
73	regulation of neurotransmitter uptake (GO:0051580)	2.55023346
74	GPI anchor metabolic process (GO:0006505)	2.54621320
75	regulation of telomere maintenance (GO:0032204)	2.53246965
76	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.53003379
77	otic vesicle formation (GO:0030916)	2.52489679
78	synaptic transmission, cholinergic (GO:0007271)	2.52449897
79	pyrimidine nucleobase catabolic process (GO:0006208)	2.51899796
80	endoderm formation (GO:0001706)	2.49803267
81	presynaptic membrane assembly (GO:0097105)	2.48268164
82	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.48205311
83	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.48205311
84	postsynaptic membrane organization (GO:0001941)	2.47553945
85	positive regulation of T-helper 1 type immune response (GO:0002827)	2.46083875
86	positive regulation of fatty acid oxidation (GO:0046321)	2.45564599
87	auditory behavior (GO:0031223)	2.44908081
88	regulation of hippo signaling (GO:0035330)	2.44787158
89	male meiosis I (GO:0007141)	2.44451795
90	positive regulation of defense response to virus by host (GO:0002230)	2.44158763
91	limb bud formation (GO:0060174)	2.43334019
92	positive regulation of fatty acid transport (GO:2000193)	2.43317800
93	spinal cord motor neuron differentiation (GO:0021522)	2.42097625
94	regulation of collateral sprouting (GO:0048670)	2.40178776
95	piRNA metabolic process (GO:0034587)	2.40023482
96	positive regulation of fatty acid beta-oxidation (GO:0032000)	2.39139860
97	fucosylation (GO:0036065)	2.39068738
98	amine catabolic process (GO:0009310)	2.36818742
99	cellular biogenic amine catabolic process (GO:0042402)	2.36818742
100	nonmotile primary cilium assembly (GO:0035058)	2.36620596

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.15024835
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.60239265
3	VDR_22108803_ChIP-Seq_LS180_Human	3.04815614
4	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.74883577
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.65090847
6	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.64867826
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.42551376
8	GBX2_23144817_ChIP-Seq_PC3_Human	2.37810130
9	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.30117161
10	EWS_26573619_Chip-Seq_HEK293_Human	2.02684081
11	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.01967727
12	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.01058480
13	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.00803179
14	IRF1_19129219_ChIP-ChIP_H3396_Human	1.96139515
15	FUS_26573619_Chip-Seq_HEK293_Human	1.94947932
16	IGF1R_20145208_ChIP-Seq_DFB_Human	1.93258381
17	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.92100132
18	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.90944531
19	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.86828179
20	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.86601348
21	TAF15_26573619_Chip-Seq_HEK293_Human	1.83252107
22	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.81886483
23	P300_19829295_ChIP-Seq_ESCs_Human	1.78167803
24	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.77387139
25	ER_23166858_ChIP-Seq_MCF-7_Human	1.71708131
26	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.66071772
27	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.65899931
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.65822151
29	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.64079387
30	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.61681222
31	REST_21632747_ChIP-Seq_MESCs_Mouse	1.60207764
32	MYC_18940864_ChIP-ChIP_HL60_Human	1.57846265
33	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.56502354
34	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.53151473
35	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.51608339
36	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.50361685
37	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.43635298
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.40615248
39	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.37987026
40	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.37749703
41	BCAT_22108803_ChIP-Seq_LS180_Human	1.37370779
42	CBP_20019798_ChIP-Seq_JUKART_Human	1.36498178
43	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.36498178
44	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.35824029
45	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.35751468
46	RNF2_27304074_Chip-Seq_NSC_Mouse	1.35728524
47	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.35186469
48	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.34635044
49	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.33159235
50	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.32590446
51	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.32590446
52	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.30337602
53	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.28296454
54	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.25357770
55	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.25133759
56	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.24756986
57	SMAD4_21799915_ChIP-Seq_A2780_Human	1.23739160
58	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.23259838
59	TCF4_23295773_ChIP-Seq_U87_Human	1.23256296
60	STAT3_23295773_ChIP-Seq_U87_Human	1.22811758
61	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.22456827
62	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.22107972
63	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.22107972
64	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.20277178
65	SOX2_19829295_ChIP-Seq_ESCs_Human	1.20251129
66	NANOG_19829295_ChIP-Seq_ESCs_Human	1.20251129
67	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.20176679
68	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.19759251
69	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.19492726
70	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.18694453
71	AR_25329375_ChIP-Seq_VCAP_Human	1.18454741
72	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.16779702
73	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.16570584
74	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.15352743
75	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.14730221
76	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.13704904
77	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.13455849
78	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.13370318
79	NCOR_22424771_ChIP-Seq_293T_Human	1.12952162
80	TDRD3_21172665_ChIP-Seq_MCF-7_Human	1.12807544
81	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.12733177
82	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.12620576
83	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.12144324
84	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.12114367
85	AR_21572438_ChIP-Seq_LNCaP_Human	1.09063452
86	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.08425400
87	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.08276045
88	RUNX2_22187159_ChIP-Seq_PCA_Human	1.06409189
89	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.06328005
90	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.05158130
91	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.05050235
92	TCF4_22108803_ChIP-Seq_LS180_Human	1.04803387
93	AR_20517297_ChIP-Seq_VCAP_Human	1.04092432
94	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.03519978
95	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.03218681
96	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.02062302
97	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.01614000
98	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.00465983
99	HOXB7_26014856_ChIP-Seq_BT474_Human	1.00333200
100	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.99556129

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0006292_abnormal_olfactory_placode	3.25560211
2	MP0004885_abnormal_endolymph	2.58466414
3	MP0003136_yellow_coat_color	2.55030889
4	MP0001968_abnormal_touch/_nociception	2.40773748
5	MP0002102_abnormal_ear_morphology	2.36585583
6	MP0003195_calcinosis	2.31935714
7	MP0008877_abnormal_DNA_methylation	2.30687881
8	MP0008872_abnormal_physiological_respon	2.20623303
9	MP0005551_abnormal_eye_electrophysiolog	2.10313618
10	MP0002736_abnormal_nociception_after	2.09535479
11	MP0002837_dystrophic_cardiac_calcinosis	2.08025470
12	MP0005646_abnormal_pituitary_gland	2.03621896
13	MP0001986_abnormal_taste_sensitivity	1.95707419
14	MP0003646_muscle_fatigue	1.94522341
15	MP0000569_abnormal_digit_pigmentation	1.93195502
16	MP0002638_abnormal_pupillary_reflex	1.93112671
17	MP0004142_abnormal_muscle_tone	1.92002008
18	MP0004133_heterotaxia	1.90473316
19	MP0002938_white_spotting	1.90252535
20	MP0009745_abnormal_behavioral_response	1.90181749
21	MP0004145_abnormal_muscle_electrophysio	1.89108937
22	MP0001485_abnormal_pinna_reflex	1.85033962
23	MP0006072_abnormal_retinal_apoptosis	1.84444500
24	MP0002272_abnormal_nervous_system	1.83179175
25	MP0002160_abnormal_reproductive_system	1.78512085
26	MP0005084_abnormal_gallbladder_morpholo	1.78449510
27	MP0003011_delayed_dark_adaptation	1.77609609
28	MP0002653_abnormal_ependyma_morphology	1.77507698
29	MP0002138_abnormal_hepatobiliary_system	1.73606113
30	MP0000631_abnormal_neuroendocrine_gland	1.72669604
31	MP0002876_abnormal_thyroid_physiology	1.67801807
32	MP0009046_muscle_twitch	1.67069226
33	MP0003787_abnormal_imprinting	1.62151211
34	MP0002928_abnormal_bile_duct	1.61685621
35	MP0005389_reproductive_system_phenotype	1.61102120
36	MP0002735_abnormal_chemical_nociception	1.53719346
37	MP0005645_abnormal_hypothalamus_physiol	1.50942729
38	MP0004742_abnormal_vestibular_system	1.50859816
39	MP0008875_abnormal_xenobiotic_pharmacok	1.47492137
40	MP0000049_abnormal_middle_ear	1.42448308
41	MP0001188_hyperpigmentation	1.40808775
42	MP0001919_abnormal_reproductive_system	1.40784289
43	MP0009379_abnormal_foot_pigmentation	1.40763743
44	MP0001486_abnormal_startle_reflex	1.40585141
45	MP0000372_irregular_coat_pigmentation	1.33184676
46	MP0004147_increased_porphyrin_level	1.33009383
47	MP0002064_seizures	1.32996998
48	MP0005253_abnormal_eye_physiology	1.31867839
49	MP0005377_hearing/vestibular/ear_phenot	1.29680197
50	MP0003878_abnormal_ear_physiology	1.29680197
51	MP0006276_abnormal_autonomic_nervous	1.29661256
52	MP0003880_abnormal_central_pattern	1.27463434
53	MP0002733_abnormal_thermal_nociception	1.25748091
54	MP0005174_abnormal_tail_pigmentation	1.22977325
55	MP0002277_abnormal_respiratory_mucosa	1.22336739
56	MP0001501_abnormal_sleep_pattern	1.22019541
57	MP0001970_abnormal_pain_threshold	1.21097807
58	MP0002572_abnormal_emotion/affect_behav	1.19020409
59	MP0002557_abnormal_social/conspecific_i	1.18733969
60	MP0000026_abnormal_inner_ear	1.17900522
61	MP0002734_abnormal_mechanical_nocicepti	1.10086427
62	MP0000427_abnormal_hair_cycle	1.08981476
63	MP0004043_abnormal_pH_regulation	1.08957560
64	MP0005195_abnormal_posterior_eye	1.08258172
65	MP0001905_abnormal_dopamine_level	1.04516901
66	MP0002067_abnormal_sensory_capabilities	1.02067722
67	MP0003635_abnormal_synaptic_transmissio	1.02053881
68	MP0003938_abnormal_ear_development	1.01144650
69	MP0002163_abnormal_gland_morphology	0.99922940
70	MP0001440_abnormal_grooming_behavior	0.99689373
71	MP0002752_abnormal_somatic_nervous	0.98851076
72	MP0002063_abnormal_learning/memory/cond	0.98618345
73	MP0001529_abnormal_vocalization	0.96422340
74	MP0001984_abnormal_olfaction	0.96342447
75	MP0008789_abnormal_olfactory_epithelium	0.96062670
76	MP0003252_abnormal_bile_duct	0.95721098
77	MP0001963_abnormal_hearing_physiology	0.93646802
78	MP0003937_abnormal_limbs/digits/tail_de	0.93638706
79	MP0003119_abnormal_digestive_system	0.93578831
80	MP0000778_abnormal_nervous_system	0.93184426
81	MP0002184_abnormal_innervation	0.93089205
82	MP0002751_abnormal_autonomic_nervous	0.91837521
83	MP0001293_anophthalmia	0.90962573
84	MP0003638_abnormal_response/metabolism_	0.90612933
85	MP0002234_abnormal_pharynx_morphology	0.90034754
86	MP0003283_abnormal_digestive_organ	0.87624823
87	MP0004134_abnormal_chest_morphology	0.85830530
88	MP0003567_abnormal_fetal_cardiomyocyte	0.85794752
89	MP0001502_abnormal_circadian_rhythm	0.85755310
90	MP0010386_abnormal_urinary_bladder	0.84367871
91	MP0003890_abnormal_embryonic-extraembry	0.82819103
92	MP0008995_early_reproductive_senescence	0.80208883
93	MP0005410_abnormal_fertilization	0.78885364
94	MP0004924_abnormal_behavior	0.77834162
95	MP0005386_behavior/neurological_phenoty	0.77834162
96	MP0005379_endocrine/exocrine_gland_phen	0.76498581
97	MP0009250_abnormal_appendicular_skeleto	0.75887599
98	MP0005187_abnormal_penis_morphology	0.75528361
99	MP0005423_abnormal_somatic_nervous	0.75472893
100	MP0004130_abnormal_muscle_cell	0.75411945

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.23604817
2	True hermaphroditism (HP:0010459)	3.88289220
3	Pancreatic fibrosis (HP:0100732)	3.87940566
4	Congenital stationary night blindness (HP:0007642)	3.77438036
5	Abnormality of midbrain morphology (HP:0002418)	3.68816928
6	Molar tooth sign on MRI (HP:0002419)	3.68816928
7	Pendular nystagmus (HP:0012043)	3.52707235
8	Nephronophthisis (HP:0000090)	3.37140336
9	Progressive cerebellar ataxia (HP:0002073)	3.08571720
10	Abolished electroretinogram (ERG) (HP:0000550)	3.08223128
11	Abnormality of the renal cortex (HP:0011035)	2.99540299
12	Genetic anticipation (HP:0003743)	2.96026318
13	Abnormality of the renal medulla (HP:0100957)	2.84638834
14	Type II lissencephaly (HP:0007260)	2.80098901
15	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.72405059
16	Abnormal rod and cone electroretinograms (HP:0008323)	2.71545724
17	Cystic liver disease (HP:0006706)	2.67844117
18	Keratoconus (HP:0000563)	2.67030380
19	Increased corneal curvature (HP:0100692)	2.67030380
20	Tubular atrophy (HP:0000092)	2.66771858
21	Concave nail (HP:0001598)	2.65738267
22	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.61661351
23	Septo-optic dysplasia (HP:0100842)	2.59982340
24	Congenital, generalized hypertrichosis (HP:0004540)	2.57917724
25	Decreased central vision (HP:0007663)	2.57063821
26	Sclerocornea (HP:0000647)	2.56249839
27	3-Methylglutaconic aciduria (HP:0003535)	2.43288957
28	Attenuation of retinal blood vessels (HP:0007843)	2.35904042
29	Optic nerve hypoplasia (HP:0000609)	2.34162439
30	Furrowed tongue (HP:0000221)	2.34075845
31	Chorioretinal atrophy (HP:0000533)	2.32446606
32	Methylmalonic acidemia (HP:0002912)	2.32305156
33	Chronic hepatic failure (HP:0100626)	2.32175866
34	Aplasia/hypoplasia of the uterus (HP:0008684)	2.31849406
35	Absent/shortened dynein arms (HP:0200106)	2.30743794
36	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.30743794
37	Inability to walk (HP:0002540)	2.29923385
38	Aplasia/Hypoplasia of the spleen (HP:0010451)	2.28460936
39	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.24156004
40	Medial flaring of the eyebrow (HP:0010747)	2.22696453
41	Agitation (HP:0000713)	2.22640138
42	Stomach cancer (HP:0012126)	2.22050659
43	Asplenia (HP:0001746)	2.20863409
44	Bilateral microphthalmos (HP:0007633)	2.20362278
45	Severe visual impairment (HP:0001141)	2.15860696
46	Anencephaly (HP:0002323)	2.14591049
47	Aplasia/Hypoplasia of the fovea (HP:0008060)	2.14301522
48	Hypoplasia of the fovea (HP:0007750)	2.14301522
49	Hypoplasia of the uterus (HP:0000013)	2.14267271
50	Hypoplasia of the pons (HP:0012110)	2.12158162
51	Renal cortical cysts (HP:0000803)	2.10490845
52	Abnormality of the pons (HP:0007361)	2.10301933
53	Hyperventilation (HP:0002883)	2.08738339
54	Aplasia/Hypoplasia of the patella (HP:0006498)	2.06542875
55	Abnormal number of erythroid precursors (HP:0012131)	2.05413935
56	Gaze-evoked nystagmus (HP:0000640)	2.03455161
57	Abnormal respiratory motile cilium morphology (HP:0005938)	2.01239338
58	Abnormal respiratory epithelium morphology (HP:0012253)	2.01239338
59	Polydipsia (HP:0001959)	2.00900594
60	Abnormal drinking behavior (HP:0030082)	2.00900594
61	Abnormality of the phalanges of the 2nd finger (HP:0009541)	2.00546293
62	Lissencephaly (HP:0001339)	1.99905142
63	Congenital hepatic fibrosis (HP:0002612)	1.99479992
64	Methylmalonic aciduria (HP:0012120)	1.99094599
65	Broad-based gait (HP:0002136)	1.98963091
66	Male pseudohermaphroditism (HP:0000037)	1.97659944
67	Mitochondrial inheritance (HP:0001427)	1.97112920
68	Hemiparesis (HP:0001269)	1.95093170
69	Large for gestational age (HP:0001520)	1.95068758
70	Progressive inability to walk (HP:0002505)	1.94351431
71	Decreased circulating renin level (HP:0003351)	1.92648838
72	Patellar aplasia (HP:0006443)	1.88587939
73	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.87523351
74	Confusion (HP:0001289)	1.86985563
75	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.86914186
76	Polyuria (HP:0000103)	1.85884719
77	Increased CSF lactate (HP:0002490)	1.82072066
78	Abnormality of the fovea (HP:0000493)	1.79958217
79	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.79142754
80	Acute necrotizing encephalopathy (HP:0006965)	1.77870913
81	Prostate neoplasm (HP:0100787)	1.77347902
82	Pachygyria (HP:0001302)	1.76310794
83	Bony spicule pigmentary retinopathy (HP:0007737)	1.75605104
84	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.74242598
85	Severe muscular hypotonia (HP:0006829)	1.72904500
86	Small hand (HP:0200055)	1.72743319
87	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.72522727
88	Adactyly (HP:0009776)	1.71320907
89	Absent thumb (HP:0009777)	1.70352662
90	Congenital sensorineural hearing impairment (HP:0008527)	1.69659986
91	Optic disc pallor (HP:0000543)	1.69500410
92	Abnormality of cells of the erythroid lineage (HP:0012130)	1.68889613
93	Abnormality of the phalanges of the 5th finger (HP:0004213)	1.68198665
94	Abnormality of the proximal phalanges of the hand (HP:0009834)	1.67797890
95	Abnormality of the middle phalanges of the toes (HP:0010183)	1.66018453
96	Symphalangism affecting the phalanges of the hand (HP:0009773)	1.65229535
97	Lipid accumulation in hepatocytes (HP:0006561)	1.64930309
98	Abnormality of the renal collecting system (HP:0004742)	1.64585539
99	Hepatocellular necrosis (HP:0001404)	1.64077476
100	Short hallux (HP:0010109)	1.64030464

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	4.07524694
2	ADRBK2	3.83318282
3	BMPR1B	3.61580307
4	TLK1	3.23875109
5	PINK1	3.16001660
6	GRK1	3.01078896
7	ZAK	2.99970797
8	WNK4	2.48579086
9	TAOK3	2.32656862
10	WNK3	2.28492512
11	MAP4K2	2.25931055
12	CASK	2.24974221
13	TXK	2.03860160
14	NUAK1	1.89030160
15	MAPK13	1.72307936
16	MAPK15	1.62907239
17	TAF1	1.56732837
18	ACVR1B	1.55327123
19	DYRK2	1.55307858
20	OXSR1	1.53120778
21	DAPK2	1.51137707
22	VRK1	1.40217082
23	PNCK	1.25156096
24	VRK2	1.20055600
25	TIE1	1.20025873
26	MAP3K4	1.15238034
27	STK39	1.14723052
28	INSRR	1.13963107
29	MARK1	1.12688706
30	PAK3	1.07297710
31	PRKCG	1.04964962
32	MKNK2	1.03270309
33	ADRBK1	1.03117175
34	PLK2	0.99590037
35	TGFBR1	0.96961204
36	NME1	0.92765270
37	PRKCE	0.91411232
38	CSNK1G2	0.87228298
39	PIK3CA	0.86052114
40	PHKG2	0.80817014
41	PHKG1	0.80817014
42	PRKCI	0.80615328
43	PTK2B	0.80508896
44	CSNK1G1	0.79668280
45	GRK7	0.78273723
46	TNIK	0.78212054
47	NTRK3	0.77469694
48	MUSK	0.75921959
49	NTRK2	0.75897208
50	IKBKB	0.75150920
51	CSNK1G3	0.73977826
52	STK16	0.73699498
53	AKT3	0.66656123
54	STK11	0.66450487
55	EPHB2	0.63850102
56	MAP2K2	0.63719485
57	MAPKAPK3	0.61502567
58	ERBB2	0.61085563
59	KIT	0.60514007
60	RPS6KA5	0.60353243
61	CSNK1A1L	0.60059862
62	WEE1	0.59970636
63	MAP2K7	0.58982158
64	IRAK4	0.57269130
65	EPHA3	0.56562397
66	PRKCQ	0.55811126
67	CAMK2A	0.55086639
68	GRK6	0.54678078
69	PRKACA	0.52512173
70	TRIM28	0.51983883
71	PKN1	0.51596005
72	CSNK1A1	0.50344174
73	GRK5	0.50196241
74	CAMKK2	0.50107015
75	CDK19	0.50043140
76	MAP3K9	0.49433844
77	PLK3	0.47235347
78	CDK8	0.46315107
79	PLK4	0.45860293
80	STK38L	0.45770818
81	NEK2	0.45271868
82	MAPKAPK5	0.44587257
83	CHUK	0.44225798
84	CAMK1	0.42610123
85	SGK2	0.41985359
86	PRKCZ	0.41593465
87	MAP2K6	0.40461752
88	RPS6KA6	0.40385195
89	MARK3	0.39339548
90	TEC	0.37693195
91	IRAK1	0.36953594
92	PRKCA	0.35666630
93	FGFR2	0.35113652
94	PRKD2	0.32190758
95	CSNK1D	0.31695500
96	IGF1R	0.31382020
97	MATK	0.31249822
98	ITK	0.31236075
99	TSSK6	0.30785113
100	MAP2K1	0.29703226

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Phototransduction_Homo sapiens_hsa04744	2.89019851
2	Oxidative phosphorylation_Homo sapiens_hsa00190	2.80482718
3	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.50218576
4	Nicotine addiction_Homo sapiens_hsa05033	2.41423364
5	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.36779087
6	Linoleic acid metabolism_Homo sapiens_hsa00591	2.24417761
7	Parkinsons disease_Homo sapiens_hsa05012	2.22687232
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.15686689
9	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.12846249
10	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.11518100
11	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.07535696
12	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.99509408
13	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.96110719
14	Caffeine metabolism_Homo sapiens_hsa00232	1.85737740
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.83894612
16	Butanoate metabolism_Homo sapiens_hsa00650	1.72522354
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.71159212
18	Homologous recombination_Homo sapiens_hsa03440	1.69708804
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.69610108
20	Selenocompound metabolism_Homo sapiens_hsa00450	1.64655344
21	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.59548479
22	Cardiac muscle contraction_Homo sapiens_hsa04260	1.57773195
23	Alzheimers disease_Homo sapiens_hsa05010	1.55018336
24	Morphine addiction_Homo sapiens_hsa05032	1.49611056
25	Ribosome_Homo sapiens_hsa03010	1.46763031
26	Protein export_Homo sapiens_hsa03060	1.46620345
27	Olfactory transduction_Homo sapiens_hsa04740	1.45368036
28	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.42454825
29	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.41644437
30	RNA polymerase_Homo sapiens_hsa03020	1.40552777
31	Huntingtons disease_Homo sapiens_hsa05016	1.39918044
32	Chemical carcinogenesis_Homo sapiens_hsa05204	1.39867872
33	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.37673035
34	Taste transduction_Homo sapiens_hsa04742	1.32865391
35	Sulfur metabolism_Homo sapiens_hsa00920	1.31786520
36	Ether lipid metabolism_Homo sapiens_hsa00565	1.30470155
37	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.26356232
38	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.22965515
39	Basal transcription factors_Homo sapiens_hsa03022	1.22695465
40	Fanconi anemia pathway_Homo sapiens_hsa03460	1.22010003
41	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.17509537
42	Retinol metabolism_Homo sapiens_hsa00830	1.14904721
43	Insulin secretion_Homo sapiens_hsa04911	1.11790873
44	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.11074219
45	RNA degradation_Homo sapiens_hsa03018	1.08455429
46	Asthma_Homo sapiens_hsa05310	1.01036822
47	Glutamatergic synapse_Homo sapiens_hsa04724	0.98292257
48	Circadian entrainment_Homo sapiens_hsa04713	0.96922594
49	Primary immunodeficiency_Homo sapiens_hsa05340	0.96297916
50	Serotonergic synapse_Homo sapiens_hsa04726	0.95982642
51	GABAergic synapse_Homo sapiens_hsa04727	0.94928561
52	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.93934258
53	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.93702203
54	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.91642047
55	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.91162451
56	Peroxisome_Homo sapiens_hsa04146	0.83845234
57	Basal cell carcinoma_Homo sapiens_hsa05217	0.82785906
58	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.82659460
59	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.82072843
60	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.79912422
61	Glycerolipid metabolism_Homo sapiens_hsa00561	0.79895015
62	Histidine metabolism_Homo sapiens_hsa00340	0.78442082
63	ABC transporters_Homo sapiens_hsa02010	0.74120986
64	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.69589775
65	Fat digestion and absorption_Homo sapiens_hsa04975	0.68377527
66	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.67416933
67	Calcium signaling pathway_Homo sapiens_hsa04020	0.66602983
68	beta-Alanine metabolism_Homo sapiens_hsa00410	0.66050020
69	Propanoate metabolism_Homo sapiens_hsa00640	0.65251358
70	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.64060329
71	Regulation of autophagy_Homo sapiens_hsa04140	0.63607621
72	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.62944057
73	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.59509317
74	Salivary secretion_Homo sapiens_hsa04970	0.59337205
75	One carbon pool by folate_Homo sapiens_hsa00670	0.58249621
76	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.57795985
77	Cocaine addiction_Homo sapiens_hsa05030	0.56711632
78	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.54735567
79	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.53917551
80	Purine metabolism_Homo sapiens_hsa00230	0.52161234
81	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.48530896
82	Metabolic pathways_Homo sapiens_hsa01100	0.48412598
83	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.48180317
84	Dopaminergic synapse_Homo sapiens_hsa04728	0.47976993
85	Steroid biosynthesis_Homo sapiens_hsa00100	0.47598721
86	Type I diabetes mellitus_Homo sapiens_hsa04940	0.46047327
87	Mineral absorption_Homo sapiens_hsa04978	0.43260681
88	Collecting duct acid secretion_Homo sapiens_hsa04966	0.43057920
89	Allograft rejection_Homo sapiens_hsa05330	0.43015826
90	Cholinergic synapse_Homo sapiens_hsa04725	0.41792282
91	Graft-versus-host disease_Homo sapiens_hsa05332	0.41669767
92	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.41406586
93	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.38922686
94	Fatty acid elongation_Homo sapiens_hsa00062	0.38855836
95	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.36974778
96	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.36820347
97	cAMP signaling pathway_Homo sapiens_hsa04024	0.36700658
98	Long-term depression_Homo sapiens_hsa04730	0.36268517
99	Circadian rhythm_Homo sapiens_hsa04710	0.35718073
100	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.35688696

NIFKP4

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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