NIFKP6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.61435209
2somatic diversification of immunoglobulins involved in immune response (GO:0002208)4.49057262
3isotype switching (GO:0045190)4.49057262
4somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)4.49057262
5regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.40248961
6regulation of mitotic spindle checkpoint (GO:1903504)4.40248961
7purine nucleobase biosynthetic process (GO:0009113)4.16696854
8DNA replication checkpoint (GO:0000076)4.14058440
9nucleobase biosynthetic process (GO:0046112)4.04544515
10regulation of immunoglobulin secretion (GO:0051023)3.90035003
11telomere maintenance via semi-conservative replication (GO:0032201)3.87084661
12CENP-A containing nucleosome assembly (GO:0034080)3.82244554
13chromatin remodeling at centromere (GO:0031055)3.80653801
14telomere maintenance via recombination (GO:0000722)3.80098316
15mitotic recombination (GO:0006312)3.69428236
16regulation of DNA endoreduplication (GO:0032875)3.67688942
17IMP biosynthetic process (GO:0006188)3.65900556
18positive regulation of isotype switching (GO:0045830)3.64165460
19protein-cofactor linkage (GO:0018065)3.62036706
20ribosomal small subunit assembly (GO:0000028)3.61264202
21kinetochore assembly (GO:0051382)3.59917002
22mitochondrial respiratory chain complex I assembly (GO:0032981)3.57827096
23NADH dehydrogenase complex assembly (GO:0010257)3.57827096
24mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.57827096
25somatic recombination of immunoglobulin gene segments (GO:0016447)3.56275345
26DNA strand elongation involved in DNA replication (GO:0006271)3.50912841
27ribosomal large subunit biogenesis (GO:0042273)3.50828123
28positive regulation of DNA recombination (GO:0045911)3.50619522
29kinetochore organization (GO:0051383)3.45940639
30respiratory chain complex IV assembly (GO:0008535)3.40474005
31DNA strand elongation (GO:0022616)3.33831137
32histone exchange (GO:0043486)3.32127811
33DNA replication-dependent nucleosome organization (GO:0034723)3.27021907
34DNA replication-dependent nucleosome assembly (GO:0006335)3.27021907
35ribosome biogenesis (GO:0042254)3.25649055
36IMP metabolic process (GO:0046040)3.25041509
37protein complex biogenesis (GO:0070271)3.20955362
38mitochondrial RNA metabolic process (GO:0000959)3.20477777
39pseudouridine synthesis (GO:0001522)3.18256395
40regulation of double-strand break repair via homologous recombination (GO:0010569)3.15977832
41ribonucleoprotein complex biogenesis (GO:0022613)3.15550703
42DNA catabolic process, exonucleolytic (GO:0000738)3.13653031
43somatic diversification of immunoglobulins (GO:0016445)3.12512056
44mitochondrial respiratory chain complex assembly (GO:0033108)3.11904974
45formation of translation preinitiation complex (GO:0001731)3.10099877
46positive regulation of histone H3-K4 methylation (GO:0051571)3.08068834
47cell wall macromolecule catabolic process (GO:0016998)3.05361120
48purine nucleotide salvage (GO:0032261)3.04081728
49somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.01736099
50somatic cell DNA recombination (GO:0016444)3.01736099
51DNA topological change (GO:0006265)3.01182180
52rRNA processing (GO:0006364)3.00919900
53negative regulation of phagocytosis (GO:0050765)3.00641994
54positive regulation of granulocyte differentiation (GO:0030854)2.99703578
55synapsis (GO:0007129)2.97588569
56cellular component biogenesis (GO:0044085)2.96167519
57telomere maintenance via telomere lengthening (GO:0010833)2.95782675
58mitotic G2/M transition checkpoint (GO:0044818)2.94809010
59rRNA metabolic process (GO:0016072)2.93303914
60regulation of spindle checkpoint (GO:0090231)2.92576892
61negative regulation of DNA recombination (GO:0045910)2.91716596
62rRNA modification (GO:0000154)2.90427337
63melanin biosynthetic process (GO:0042438)2.88289948
64meiotic chromosome segregation (GO:0045132)2.88204315
65DNA deamination (GO:0045006)2.88022395
66recombinational repair (GO:0000725)2.87982874
67protein targeting to mitochondrion (GO:0006626)2.87145612
68maturation of 5.8S rRNA (GO:0000460)2.85201110
69positive regulation of cell cycle checkpoint (GO:1901978)2.85186995
70double-strand break repair via homologous recombination (GO:0000724)2.84485996
71somatic hypermutation of immunoglobulin genes (GO:0016446)2.84268817
72somatic diversification of immune receptors via somatic mutation (GO:0002566)2.84268817
73secondary metabolite biosynthetic process (GO:0044550)2.84153265
74DNA replication-independent nucleosome assembly (GO:0006336)2.82333253
75DNA replication-independent nucleosome organization (GO:0034724)2.82333253
76translation (GO:0006412)2.82003596
77chaperone-mediated protein transport (GO:0072321)2.80090985
78motile cilium assembly (GO:0044458)2.79608436
79protein localization to kinetochore (GO:0034501)2.78958136
80regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.78391055
81GTP biosynthetic process (GO:0006183)2.78385838
82B cell activation involved in immune response (GO:0002312)2.77406979
83negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.77285440
84negative regulation of DNA-dependent DNA replication (GO:2000104)2.76991521
85negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.76651275
86negative regulation of T-helper cell differentiation (GO:0045623)2.76651275
87SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.75958790
88somatic diversification of immune receptors (GO:0002200)2.74674217
89nucleotide-excision repair, DNA gap filling (GO:0006297)2.74459473
90positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.74200099
91ribosomal small subunit biogenesis (GO:0042274)2.73483636
92regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.73342050
93cotranslational protein targeting to membrane (GO:0006613)2.72649913
94mannosylation (GO:0097502)2.71491566
95anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.69847377
96positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.68743608
97mitotic chromosome condensation (GO:0007076)2.68326809
98translational termination (GO:0006415)2.67781680
99protein targeting to ER (GO:0045047)2.67381315
100viral transcription (GO:0019083)2.66853363

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.09489930
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.98549972
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.50135480
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.29977178
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.09849612
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.03744161
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.87196019
8JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.83846179
9ELF1_17652178_ChIP-ChIP_JURKAT_Human2.63219937
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.56229344
11EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.54874213
12HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.49852755
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.49676551
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.44409742
15PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.36486815
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.34586027
17ETS1_20019798_ChIP-Seq_JURKAT_Human2.34270050
18FOXP3_21729870_ChIP-Seq_TREG_Human2.31529948
19SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.30635809
20VDR_23849224_ChIP-Seq_CD4+_Human2.26296705
21ELK1_19687146_ChIP-ChIP_HELA_Human2.15459971
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.14746627
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.06343957
24E2F1_21310950_ChIP-Seq_MCF-7_Human2.03147784
25E2F7_22180533_ChIP-Seq_HELA_Human11.5112212
26FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.99609476
27HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.96268147
28SRF_21415370_ChIP-Seq_HL-1_Mouse1.89535528
29TTF2_22483619_ChIP-Seq_HELA_Human1.87836124
30DCP1A_22483619_ChIP-Seq_HELA_Human1.86944676
31SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74488317
32XRN2_22483619_ChIP-Seq_HELA_Human1.72770420
33HOXB4_20404135_ChIP-ChIP_EML_Mouse1.70238935
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62306880
35MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.58908511
36CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.55962682
37GABP_19822575_ChIP-Seq_HepG2_Human1.51765684
38KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.51719298
39PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.48714406
40KDM5A_27292631_Chip-Seq_BREAST_Human1.48544329
41CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.47849491
42NOTCH1_21737748_ChIP-Seq_TLL_Human1.43498869
43E2F1_18555785_ChIP-Seq_MESCs_Mouse1.42120446
44NELFA_20434984_ChIP-Seq_ESCs_Mouse1.39566168
45TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.37511050
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.36528295
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.33578161
48PADI4_21655091_ChIP-ChIP_MCF-7_Human1.32510539
49FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31176991
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.30770736
51FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.29520570
52MYC_18940864_ChIP-ChIP_HL60_Human1.27551840
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.25955892
54MYB_26560356_Chip-Seq_TH2_Human1.23179006
55MYCN_18555785_ChIP-Seq_MESCs_Mouse1.23168544
56EWS_26573619_Chip-Seq_HEK293_Human1.22286579
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.21678473
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.16927592
59AR_21909140_ChIP-Seq_LNCAP_Human1.15032131
60E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.13645176
61GATA1_22025678_ChIP-Seq_K562_Human1.12748625
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.11479880
63SPI1_23547873_ChIP-Seq_NB4_Human1.08869070
64ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04688510
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.04033412
66ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03762794
67ERG_20887958_ChIP-Seq_HPC-7_Mouse1.03415496
68MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.03185229
69GATA3_26560356_Chip-Seq_TH2_Human0.98988277
70FUS_26573619_Chip-Seq_HEK293_Human0.95662238
71TP53_22573176_ChIP-Seq_HFKS_Human0.93938950
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93701300
73ZFX_18555785_ChIP-Seq_MESCs_Mouse0.92934005
74CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91801239
75GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.86794052
76IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.86055434
77FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80884989
78MYB_26560356_Chip-Seq_TH1_Human0.80187018
79IRF1_19129219_ChIP-ChIP_H3396_Human0.78267857
80ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.77581003
81EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.75858268
82NANOG_18555785_ChIP-Seq_MESCs_Mouse0.74897867
83VDR_21846776_ChIP-Seq_THP-1_Human0.74709828
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.74647602
85CIITA_25753668_ChIP-Seq_RAJI_Human0.72856265
86BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.71042718
87CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.70537407
88CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.70428172
89STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.70042074
90SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.67878577
91TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.66040210
92GATA3_27048872_Chip-Seq_THYMUS_Human0.65725951
93NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.65309952
94MAF_26560356_Chip-Seq_TH2_Human0.63490062
95CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.63428667
96STAT4_19710469_ChIP-ChIP_TH1__Mouse0.61828481
97NANOG_16153702_ChIP-ChIP_HESCs_Human0.61521992
98CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.58977492
99ELF5_23300383_ChIP-Seq_T47D_Human0.57457759
100MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.56831348

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000372_irregular_coat_pigmentation5.10098881
2MP0008057_abnormal_DNA_replication4.10306140
3MP0010094_abnormal_chromosome_stability4.09299367
4MP0008058_abnormal_DNA_repair3.90437133
5MP0003693_abnormal_embryo_hatching3.45879323
6MP0005171_absent_coat_pigmentation3.11242882
7MP0003806_abnormal_nucleotide_metabolis3.10903695
8MP0003077_abnormal_cell_cycle2.53502424
9MP0003111_abnormal_nucleus_morphology2.52012461
10MP0002163_abnormal_gland_morphology2.46827479
11MP0004957_abnormal_blastocyst_morpholog2.40835342
12MP0005075_abnormal_melanosome_morpholog2.26684603
13MP0001835_abnormal_antigen_presentation2.14525898
14MP0005408_hypopigmentation2.12386229
15MP0003136_yellow_coat_color2.11170990
16MP0002396_abnormal_hematopoietic_system2.11147918
17MP0001529_abnormal_vocalization1.89109424
18MP0002095_abnormal_skin_pigmentation1.88225067
19MP0001293_anophthalmia1.86801941
20MP0000015_abnormal_ear_pigmentation1.86381272
21MP0005671_abnormal_response_to1.82363736
22MP0003786_premature_aging1.80820034
23MP0002938_white_spotting1.76429754
24MP0006292_abnormal_olfactory_placode1.73191985
25MP0002102_abnormal_ear_morphology1.72747563
26MP0008007_abnormal_cellular_replicative1.72460632
27MP0009333_abnormal_splenocyte_physiolog1.68474077
28MP0003763_abnormal_thymus_physiology1.63357191
29MP0003950_abnormal_plasma_membrane1.61041534
30MP0005174_abnormal_tail_pigmentation1.56757782
31MP0005360_urolithiasis1.55992176
32MP0008932_abnormal_embryonic_tissue1.53007356
33MP0006036_abnormal_mitochondrial_physio1.51432486
34MP0003718_maternal_effect1.47605520
35MP0000685_abnormal_immune_system1.46595124
36MP0008789_abnormal_olfactory_epithelium1.34789320
37MP0001800_abnormal_humoral_immune1.34459121
38MP0004381_abnormal_hair_follicle1.31866253
39MP0002398_abnormal_bone_marrow1.24460240
40MP0000703_abnormal_thymus_morphology1.23846283
41MP0004147_increased_porphyrin_level1.23547412
42MP0000371_diluted_coat_color1.22508338
43MP0000689_abnormal_spleen_morphology1.22412006
44MP0005000_abnormal_immune_tolerance1.18564698
45MP0002019_abnormal_tumor_incidence1.18146795
46MP0003656_abnormal_erythrocyte_physiolo1.16395959
47MP0000569_abnormal_digit_pigmentation1.15024000
48MP0002877_abnormal_melanocyte_morpholog1.14818631
49MP0006082_CNS_inflammation1.14291538
50MP0002420_abnormal_adaptive_immunity1.13141836
51MP0001819_abnormal_immune_cell1.12029861
52MP0001790_abnormal_immune_system1.10348667
53MP0005387_immune_system_phenotype1.10348667
54MP0002006_tumorigenesis1.08413105
55MP0002722_abnormal_immune_system1.07917726
56MP0002166_altered_tumor_susceptibility1.07495982
57MP0008872_abnormal_physiological_respon1.05984366
58MP0002210_abnormal_sex_determination1.04892718
59MP0005025_abnormal_response_to1.02645537
60MP0000490_abnormal_crypts_of1.01212143
61MP0008877_abnormal_DNA_methylation1.01180236
62MP0001929_abnormal_gametogenesis1.00308664
63MP0005379_endocrine/exocrine_gland_phen0.99056947
64MP0008875_abnormal_xenobiotic_pharmacok0.98786085
65MP0005551_abnormal_eye_electrophysiolog0.98225974
66MP0002429_abnormal_blood_cell0.97675610
67MP0004185_abnormal_adipocyte_glucose0.94979559
68MP0002009_preneoplasia0.94864341
69MP0010307_abnormal_tumor_latency0.94456123
70MP0002723_abnormal_immune_serum0.94150167
71MP0002233_abnormal_nose_morphology0.94049996
72MP0000716_abnormal_immune_system0.93508403
73MP0001764_abnormal_homeostasis0.91121194
74MP0006072_abnormal_retinal_apoptosis0.90881184
75MP0005645_abnormal_hypothalamus_physiol0.89324362
76MP0000313_abnormal_cell_death0.89023546
77MP0005499_abnormal_olfactory_system0.88350760
78MP0005394_taste/olfaction_phenotype0.88350760
79MP0001485_abnormal_pinna_reflex0.87403700
80MP0008873_increased_physiological_sensi0.86502651
81MP0002452_abnormal_antigen_presenting0.84717623
82MP0003567_abnormal_fetal_cardiomyocyte0.84054486
83MP0000350_abnormal_cell_proliferation0.83378255
84MP0000358_abnormal_cell_content/0.82997130
85MP0008995_early_reproductive_senescence0.80332882
86MP0001697_abnormal_embryo_size0.78502300
87MP0003943_abnormal_hepatobiliary_system0.77905631
88MP0001119_abnormal_female_reproductive0.77568322
89MP0006035_abnormal_mitochondrial_morpho0.76241063
90MP0009785_altered_susceptibility_to0.73683535
91MP0001986_abnormal_taste_sensitivity0.72784145
92MP0002419_abnormal_innate_immunity0.71897478
93MP0001324_abnormal_eye_pigmentation0.69979444
94MP0001545_abnormal_hematopoietic_system0.69763172
95MP0005397_hematopoietic_system_phenotyp0.69763172
96MP0004808_abnormal_hematopoietic_stem0.69609348
97MP0002075_abnormal_coat/hair_pigmentati0.69048364
98MP0001145_abnormal_male_reproductive0.67339261
99MP0001186_pigmentation_phenotype0.65689595
100MP0000653_abnormal_sex_gland0.64835397

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.74719699
2Chromsome breakage (HP:0040012)5.17879414
3Stomatitis (HP:0010280)4.89089023
4Duplicated collecting system (HP:0000081)4.45361916
5Abnormality of the renal collecting system (HP:0004742)3.94094786
6Reticulocytopenia (HP:0001896)3.52755251
7Aplasia/Hypoplasia of the uvula (HP:0010293)3.45264800
8Meckel diverticulum (HP:0002245)3.26661040
9Abnormality of the preputium (HP:0100587)3.23348323
10Abnormality of the prostate (HP:0008775)3.15425178
11Microvesicular hepatic steatosis (HP:0001414)3.09681232
12Abnormality of chromosome stability (HP:0003220)3.05224799
13Abnormality of the ileum (HP:0001549)2.98165442
14Increased serum pyruvate (HP:0003542)2.96545427
15Progressive muscle weakness (HP:0003323)2.92634869
16Increased IgM level (HP:0003496)2.92246598
17Abnormality of the pons (HP:0007361)2.90683329
18Abnormal gallbladder physiology (HP:0012438)2.88697367
19Cholecystitis (HP:0001082)2.88697367
20Tubulointerstitial nephritis (HP:0001970)2.86426702
21IgG deficiency (HP:0004315)2.84289433
22Abnormality of glycolysis (HP:0004366)2.83600436
23Rhabdomyosarcoma (HP:0002859)2.83479138
24Thrombocytosis (HP:0001894)2.65308967
25Aplasia/Hypoplasia of the fovea (HP:0008060)2.63632507
26Hypoplasia of the fovea (HP:0007750)2.63632507
27Abnormality of T cell physiology (HP:0011840)2.62528341
28Duodenal stenosis (HP:0100867)2.57323235
29Small intestinal stenosis (HP:0012848)2.57323235
30Absent thumb (HP:0009777)2.55634429
31Colon cancer (HP:0003003)2.52754304
32Abnormality of cells of the erythroid lineage (HP:0012130)2.51762482
33Elevated erythrocyte sedimentation rate (HP:0003565)2.51020242
34Ureteral duplication (HP:0000073)2.50830497
35Abnormality of the labia minora (HP:0012880)2.48706444
36Abnormality of DNA repair (HP:0003254)2.41514333
37Clubbing of toes (HP:0100760)2.36251763
38Sloping forehead (HP:0000340)2.35091080
39Abnormal number of erythroid precursors (HP:0012131)2.34055407
40Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.33525301
41Myelodysplasia (HP:0002863)2.31793089
42Oligodactyly (hands) (HP:0001180)2.31056674
43Ependymoma (HP:0002888)2.30492370
44Hepatocellular necrosis (HP:0001404)2.30206147
45Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.29369787
46Increased serum lactate (HP:0002151)2.26574019
47Irregular epiphyses (HP:0010582)2.25012189
48Ectopic kidney (HP:0000086)2.24278163
49B lymphocytopenia (HP:0010976)2.23421468
50Abnormality of B cell number (HP:0010975)2.14354813
51Impulsivity (HP:0100710)2.12431189
52Aplastic anemia (HP:0001915)2.10120323
53Premature graying of hair (HP:0002216)2.09500553
54Neutropenia (HP:0001875)2.08960734
55Increased CSF lactate (HP:0002490)2.07256077
56Fatigue (HP:0012378)2.07154186
57Postnatal microcephaly (HP:0005484)2.06387954
58Absent radius (HP:0003974)2.04032279
59Abnormality of the duodenum (HP:0002246)2.02884843
60Abnormality of the fovea (HP:0000493)2.02544357
613-Methylglutaconic aciduria (HP:0003535)1.99480667
62Pancytopenia (HP:0001876)1.98655528
63Mitochondrial inheritance (HP:0001427)1.98545032
64Hepatic necrosis (HP:0002605)1.95996990
65Birth length less than 3rd percentile (HP:0003561)1.94783952
66Abnormality of T cells (HP:0002843)1.94164288
67Short thumb (HP:0009778)1.94150715
68Aplasia/Hypoplasia of the macula (HP:0008059)1.93886114
69Absent forearm bone (HP:0003953)1.93572489
70Aplasia involving forearm bones (HP:0009822)1.93572489
71IgA deficiency (HP:0002720)1.92358990
72Pancreatic fibrosis (HP:0100732)1.91180306
73Poor head control (HP:0002421)1.90953371
74Cleft eyelid (HP:0000625)1.87511465
75Hypoplasia of the pons (HP:0012110)1.87315579
76Type 2 muscle fiber atrophy (HP:0003554)1.86229477
77Neoplasm of striated muscle (HP:0009728)1.86163428
78Abnormality of the carotid arteries (HP:0005344)1.85932610
79Abnormality of male internal genitalia (HP:0000022)1.85737580
80Lipid accumulation in hepatocytes (HP:0006561)1.85171241
81Pancreatic cysts (HP:0001737)1.84202005
82Asplenia (HP:0001746)1.84066708
83Bone marrow hypocellularity (HP:0005528)1.84024461
84Exercise intolerance (HP:0003546)1.83748181
85Abnormality of pyrimidine metabolism (HP:0004353)1.82269572
86Nephroblastoma (Wilms tumor) (HP:0002667)1.81126623
87Supernumerary spleens (HP:0009799)1.81022314
88Lissencephaly (HP:0001339)1.79328929
89Enlarged kidneys (HP:0000105)1.78813823
90Severe combined immunodeficiency (HP:0004430)1.78382904
91Granulocytopenia (HP:0001913)1.77585793
92Triphalangeal thumb (HP:0001199)1.77101392
93Basal cell carcinoma (HP:0002671)1.76412613
94Aplasia/Hypoplasia affecting the retina (HP:0008061)1.76291233
95Acute necrotizing encephalopathy (HP:0006965)1.75229254
96Progressive microcephaly (HP:0000253)1.73203710
97Carpal bone hypoplasia (HP:0001498)1.72131580
98Type II lissencephaly (HP:0007260)1.71379460
99Poor speech (HP:0002465)1.71013636
100Acute myeloid leukemia (HP:0004808)1.70757401

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRSK24.29196403
2TRIM283.76378110
3PBK3.63775965
4CDK193.31854289
5ZAK3.28964215
6CDC73.26481200
7VRK23.08280737
8WNK42.66226583
9EIF2AK12.56541608
10TSSK62.52986884
11BRSK12.40323622
12TTK2.25411789
13VRK12.17040281
14MARK32.11785287
15WEE12.07020986
16BUB12.07019032
17PIK3CG1.99944480
18PLK31.94556347
19STK391.91519149
20NUAK11.83995749
21MKNK21.81891479
22BCKDK1.67451718
23ATR1.66357152
24OXSR11.65046587
25MAP4K21.64461709
26SRPK11.58541720
27EIF2AK31.56577557
28MST41.43554152
29TLK11.39639937
30CHEK21.37990220
31PLK41.36103090
32NME11.27222183
33PLK11.14268614
34MAP4K11.13093188
35NEK11.11142366
36SIK31.08839890
37STK41.08783045
38STK161.08327644
39MKNK11.06226507
40WNK10.92253171
41CHEK10.91829249
42TAF10.91780490
43WNK30.89317276
44EIF2AK20.87211095
45ALK0.85307712
46BRD40.84982088
47INSRR0.81372339
48FGFR10.81323559
49CDK40.78837410
50PDK20.77504270
51AURKB0.77191315
52BMPR1B0.74770501
53CLK10.72010256
54ATM0.69543382
55ACVR1B0.67870974
56FES0.66909363
57TEC0.61471970
58PRKCQ0.58265235
59PIM10.58012894
60PTK2B0.57611596
61ITK0.57404535
62TNIK0.55046466
63TXK0.54013298
64ADRBK20.53547721
65RPS6KA40.53213524
66CDK30.50642107
67TAOK30.47265616
68SYK0.45527560
69PASK0.45261152
70SIK20.45127131
71STK30.45123782
72DYRK20.45022743
73RPS6KB20.44228047
74CSNK2A20.42008434
75NEK20.41392096
76SCYL20.40990124
77CDK10.40986768
78CAMKK20.40435861
79MELK0.39884008
80BMPR20.36627104
81AURKA0.35889840
82CSNK2A10.35727474
83MAP3K80.35241999
84MAPK130.34795447
85CDK60.34463750
86CCNB10.32208790
87LYN0.31811628
88RIPK40.29749957
89CDK20.29353696
90LCK0.29245936
91MINK10.28916734
92RPS6KA10.28272478
93TYK20.27406003
94GRK60.26664547
95CDK70.25660357
96RPS6KA50.25096180
97KDR0.24575336
98BTK0.23283589
99TNK20.22422030
100ABL20.20825012

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.91023168
2Mismatch repair_Homo sapiens_hsa034303.74590357
3Protein export_Homo sapiens_hsa030603.35178709
4Proteasome_Homo sapiens_hsa030503.26604257
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.19659821
6Ribosome_Homo sapiens_hsa030103.16797791
7Vitamin B6 metabolism_Homo sapiens_hsa007503.13923223
8Homologous recombination_Homo sapiens_hsa034403.08834532
9Fanconi anemia pathway_Homo sapiens_hsa034602.94960668
10Asthma_Homo sapiens_hsa053102.68223615
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.65694087
12Base excision repair_Homo sapiens_hsa034102.55942720
13Non-homologous end-joining_Homo sapiens_hsa034502.49061158
14Nucleotide excision repair_Homo sapiens_hsa034202.26096327
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.08022399
16RNA polymerase_Homo sapiens_hsa030202.05126555
17RNA transport_Homo sapiens_hsa030132.04622645
18Primary immunodeficiency_Homo sapiens_hsa053402.03091793
19Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.94278600
20Allograft rejection_Homo sapiens_hsa053301.94094435
21Intestinal immune network for IgA production_Homo sapiens_hsa046721.93796355
22Autoimmune thyroid disease_Homo sapiens_hsa053201.88812126
23Cell cycle_Homo sapiens_hsa041101.88425017
24Spliceosome_Homo sapiens_hsa030401.86126059
25Pyrimidine metabolism_Homo sapiens_hsa002401.80958780
26One carbon pool by folate_Homo sapiens_hsa006701.80726646
27RNA degradation_Homo sapiens_hsa030181.74288399
28Basal transcription factors_Homo sapiens_hsa030221.70655495
29Oxidative phosphorylation_Homo sapiens_hsa001901.66066729
30Parkinsons disease_Homo sapiens_hsa050121.37792266
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.17442984
32Purine metabolism_Homo sapiens_hsa002301.12723543
33Folate biosynthesis_Homo sapiens_hsa007901.09075623
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07898969
35T cell receptor signaling pathway_Homo sapiens_hsa046601.03159200
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.00565246
37Butanoate metabolism_Homo sapiens_hsa006500.99624054
38Huntingtons disease_Homo sapiens_hsa050160.94962237
39Pyruvate metabolism_Homo sapiens_hsa006200.92293178
40Systemic lupus erythematosus_Homo sapiens_hsa053220.88486865
41mRNA surveillance pathway_Homo sapiens_hsa030150.81593754
42Cardiac muscle contraction_Homo sapiens_hsa042600.79862064
43Propanoate metabolism_Homo sapiens_hsa006400.72358238
44Measles_Homo sapiens_hsa051620.69627763
45Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.66525782
46Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66340906
47Alzheimers disease_Homo sapiens_hsa050100.66244565
48p53 signaling pathway_Homo sapiens_hsa041150.64935289
49Oocyte meiosis_Homo sapiens_hsa041140.62837658
50Sulfur relay system_Homo sapiens_hsa041220.61239778
51Cyanoamino acid metabolism_Homo sapiens_hsa004600.61028475
52Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59680985
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.59006869
54Selenocompound metabolism_Homo sapiens_hsa004500.56567909
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.56001404
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.54995411
57Drug metabolism - other enzymes_Homo sapiens_hsa009830.54927697
58Epstein-Barr virus infection_Homo sapiens_hsa051690.53182728
59Metabolic pathways_Homo sapiens_hsa011000.51628815
60Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51240429
61Hematopoietic cell lineage_Homo sapiens_hsa046400.48603228
62Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.48458786
63Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45727478
64Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44918652
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44395524
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44327219
67Linoleic acid metabolism_Homo sapiens_hsa005910.43968290
68Graft-versus-host disease_Homo sapiens_hsa053320.41978109
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.41815166
70Carbon metabolism_Homo sapiens_hsa012000.40278199
71Phototransduction_Homo sapiens_hsa047440.38894056
72Biosynthesis of amino acids_Homo sapiens_hsa012300.38139321
73N-Glycan biosynthesis_Homo sapiens_hsa005100.37931026
74Viral myocarditis_Homo sapiens_hsa054160.37811229
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36927601
76Caffeine metabolism_Homo sapiens_hsa002320.36287526
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.35381663
78NOD-like receptor signaling pathway_Homo sapiens_hsa046210.34073868
79Steroid biosynthesis_Homo sapiens_hsa001000.32141237
80Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.28640127
81Retinol metabolism_Homo sapiens_hsa008300.27284531
82Antigen processing and presentation_Homo sapiens_hsa046120.26986621
83Fatty acid elongation_Homo sapiens_hsa000620.24682217
84Herpes simplex infection_Homo sapiens_hsa051680.24230166
85HTLV-I infection_Homo sapiens_hsa051660.23748679
86Rheumatoid arthritis_Homo sapiens_hsa053230.21525136
87Olfactory transduction_Homo sapiens_hsa047400.21174558
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.20883611
89Regulation of autophagy_Homo sapiens_hsa041400.20140242
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.19584354
91Tryptophan metabolism_Homo sapiens_hsa003800.17018495
92Peroxisome_Homo sapiens_hsa041460.16769238
93Carbohydrate digestion and absorption_Homo sapiens_hsa049730.15805974
94Viral carcinogenesis_Homo sapiens_hsa052030.15625475
95Apoptosis_Homo sapiens_hsa042100.13949896
96SNARE interactions in vesicular transport_Homo sapiens_hsa041300.13254527
97Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.10936455
98Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.09875107
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.08355455
100Glutathione metabolism_Homo sapiens_hsa004800.06661740

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