NIN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes one of the proteins important for centrosomal function. This protein is important for positioning and anchoring the microtubules minus-ends in epithelial cells. Localization of this protein to the centrosome requires three leucine zippers in the central coiled-coil domain. Multiple alternatively spliced transcript variants that encode different isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation by symbiont of host defense response (GO:0052509)5.01579486
2modulation by symbiont of host defense response (GO:0052031)5.01579486
3modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.01579486
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.01579486
5positive regulation by organism of defense response of other organism involved in symbiotic interact5.01579486
6modulation by symbiont of host immune response (GO:0052553)5.01579486
7negative regulation of cell killing (GO:0031342)4.44686692
8negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.44686692
9positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.40170962
10protein localization to kinetochore (GO:0034501)4.36854016
11detection of molecule of bacterial origin (GO:0032490)4.36061012
12mitotic sister chromatid cohesion (GO:0007064)4.35475809
13macrophage activation involved in immune response (GO:0002281)4.26248046
14mitotic chromosome condensation (GO:0007076)4.21842071
15nuclear pore complex assembly (GO:0051292)4.13308156
16protein localization to chromosome, centromeric region (GO:0071459)3.90891381
17microglial cell activation (GO:0001774)3.88756097
18monoubiquitinated protein deubiquitination (GO:0035520)3.86454778
19detection of other organism (GO:0098543)3.85777107
20regulation of RNA export from nucleus (GO:0046831)3.81331743
21antigen processing and presentation of endogenous antigen (GO:0019883)3.76120971
22regulation of interferon-beta biosynthetic process (GO:0045357)3.75762708
23regulation of spindle organization (GO:0090224)3.73433154
24detection of external biotic stimulus (GO:0098581)3.68338622
25positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.68099350
26response to host immune response (GO:0052572)3.65221389
27response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.65221389
28phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.64020877
29positive regulation of granulocyte differentiation (GO:0030854)3.61734992
30positive regulation of gamma-delta T cell activation (GO:0046645)3.58107088
31response to host (GO:0075136)3.57070851
32response to host defenses (GO:0052200)3.57070851
33response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.57070851
34leukocyte aggregation (GO:0070486)3.55707325
35mitotic metaphase plate congression (GO:0007080)3.54049903
36sister chromatid segregation (GO:0000819)3.53935458
37response to peptidoglycan (GO:0032494)3.52494756
38negative regulation of T cell mediated immunity (GO:0002710)3.52403131
39regulation of mitotic spindle organization (GO:0060236)3.51201259
40nuclear pore organization (GO:0006999)3.51189191
41positive regulation of chromosome segregation (GO:0051984)3.49627862
42regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.48034189
43regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.46668747
44response to interleukin-15 (GO:0070672)3.43961055
45negative regulation of interleukin-12 production (GO:0032695)3.43327938
46neutrophil activation involved in immune response (GO:0002283)3.42612227
47negative regulation of lymphocyte mediated immunity (GO:0002707)3.39434202
48pore complex assembly (GO:0046931)3.39422752
49cellular extravasation (GO:0045123)3.39241170
50macrophage activation (GO:0042116)3.36882675
51detection of bacterium (GO:0016045)3.35745268
52T cell migration (GO:0072678)3.35548980
53positive regulation of mitotic sister chromatid separation (GO:1901970)3.35152951
54positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.35152951
55positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.35152951
56response to muramyl dipeptide (GO:0032495)3.31226962
57regulation of nucleobase-containing compound transport (GO:0032239)3.26814469
58detection of biotic stimulus (GO:0009595)3.23135443
59mitotic sister chromatid segregation (GO:0000070)3.20789227
60negative regulation of phagocytosis (GO:0050765)3.11825107
61myeloid cell activation involved in immune response (GO:0002275)3.11025044
62metaphase plate congression (GO:0051310)3.10773455
63activated T cell proliferation (GO:0050798)3.10134399
64regulation of B cell receptor signaling pathway (GO:0050855)3.09246897
65cellular response to interleukin-15 (GO:0071350)3.07819217
66regulation of DNA endoreduplication (GO:0032875)3.06395829
67regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.03724278
68mitotic nuclear envelope disassembly (GO:0007077)3.03559493
69neutrophil mediated immunity (GO:0002446)3.01304028
70germinal center formation (GO:0002467)3.00719868
71negative regulation of B cell proliferation (GO:0030889)2.99826824
72establishment of chromosome localization (GO:0051303)2.98521780
73B cell proliferation (GO:0042100)2.97237619
74regulation of necroptotic process (GO:0060544)2.96783836
75glucocorticoid receptor signaling pathway (GO:0042921)2.96358187
76regulation of alpha-beta T cell proliferation (GO:0046640)2.94849888
77corticosteroid receptor signaling pathway (GO:0031958)2.94813516
78regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.93591652
79positive thymic T cell selection (GO:0045059)2.93158143
80protein localization to chromosome (GO:0034502)2.92765614
81negative regulation of leukocyte mediated immunity (GO:0002704)2.91889328
82cytoplasmic mRNA processing body assembly (GO:0033962)2.90536566
83negative thymic T cell selection (GO:0045060)2.89991145
84membrane disassembly (GO:0030397)2.89198059
85nuclear envelope disassembly (GO:0051081)2.89198059
86positive regulation of interferon-alpha production (GO:0032727)2.88472322
87cellular response to ethanol (GO:0071361)2.88121602
88myeloid leukocyte mediated immunity (GO:0002444)2.87281087
89antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.87058329
90positive regulation of mast cell activation (GO:0033005)2.85964864
91negative T cell selection (GO:0043383)2.84735500
92Arp2/3 complex-mediated actin nucleation (GO:0034314)2.83762391
93neutrophil activation (GO:0042119)2.81223973
94interferon-gamma production (GO:0032609)2.81180292
95negative regulation of histone methylation (GO:0031061)2.80915657
96negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.80388554
97histone H3-K4 trimethylation (GO:0080182)2.80243456
98antigen processing and presentation via MHC class Ib (GO:0002475)2.78886172
99histone phosphorylation (GO:0016572)2.78727601
100regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.78016394
101regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.76984368
102negative regulation of erythrocyte differentiation (GO:0045647)2.76704519
103regulation of gamma-delta T cell differentiation (GO:0045586)2.76643912
104DNA replication checkpoint (GO:0000076)2.73711807
105spindle assembly involved in mitosis (GO:0090307)2.73060696
106kinetochore organization (GO:0051383)2.71322284
107response to fungus (GO:0009620)2.69153145
108negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.68532444
109negative regulation of T-helper cell differentiation (GO:0045623)2.68532444
110positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.67469456
111regulation of sister chromatid cohesion (GO:0007063)2.67372621
112antigen receptor-mediated signaling pathway (GO:0050851)2.67190954
113negative regulation of adaptive immune response (GO:0002820)2.66771268
114defense response to protozoan (GO:0042832)2.65886206
115immunoglobulin mediated immune response (GO:0016064)2.65829775
116positive regulation of B cell differentiation (GO:0045579)2.65498479
117regulation of granulocyte differentiation (GO:0030852)2.65337024
118histone H3-K36 demethylation (GO:0070544)2.65042276
119positive regulation of alpha-beta T cell proliferation (GO:0046641)2.64808785
120negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.64781269
121regulation of gamma-delta T cell activation (GO:0046643)2.64284881
122DNA unwinding involved in DNA replication (GO:0006268)2.63842378
123microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.63841396
124nuclear envelope organization (GO:0006998)2.63341587
125regulation of interferon-alpha production (GO:0032647)2.61780620
126thymic T cell selection (GO:0045061)2.61614807
127regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.61414281
128hepatocyte apoptotic process (GO:0097284)2.61340298
129regulation of mast cell degranulation (GO:0043304)2.61069362
130regulation of macrophage cytokine production (GO:0010935)2.59282975
131negative regulation of DNA-dependent DNA replication (GO:2000104)2.59045396
132regulation of interleukin-12 biosynthetic process (GO:0045075)2.58353387
133attachment of spindle microtubules to kinetochore (GO:0008608)2.58230177
134cellular response to type I interferon (GO:0071357)2.57993023
135type I interferon signaling pathway (GO:0060337)2.57993023
136response to type I interferon (GO:0034340)2.57718879
137regulation of B cell proliferation (GO:0030888)2.57099698
138B cell receptor signaling pathway (GO:0050853)2.54940707
139DNA topological change (GO:0006265)2.54170192
140positive T cell selection (GO:0043368)2.54072763
141positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.52345641
142antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.51783674
143antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.51783674
144positive regulation of histone deacetylation (GO:0031065)2.51324402
145histone mRNA catabolic process (GO:0071044)2.49086974
146dosage compensation (GO:0007549)2.48871220
147chromosome condensation (GO:0030261)2.46687824
148defense response to fungus (GO:0050832)2.45537305
149NLS-bearing protein import into nucleus (GO:0006607)2.45471759
150regulation of exit from mitosis (GO:0007096)2.43354023
151regulation of histone H3-K9 methylation (GO:0051570)2.43352358
152chromatin assembly or disassembly (GO:0006333)2.42438401
153protein localization to endosome (GO:0036010)2.42071085
154positive regulation of gene expression, epigenetic (GO:0045815)2.42060067
155histone H3-K4 methylation (GO:0051568)2.41634838
156mRNA stabilization (GO:0048255)2.40714522
157RNA stabilization (GO:0043489)2.40714522
158regulation of B cell differentiation (GO:0045577)2.40487336
159sister chromatid cohesion (GO:0007062)2.38421542
160T cell selection (GO:0045058)2.37962199
161peptidyl-lysine trimethylation (GO:0018023)2.37188270
162leukocyte migration involved in inflammatory response (GO:0002523)2.36260638
163actin nucleation (GO:0045010)2.36003322
164megakaryocyte development (GO:0035855)2.33848347
165histone-serine phosphorylation (GO:0035404)2.32115698
166chromosome segregation (GO:0007059)2.31734895
167B cell homeostasis (GO:0001782)2.31219336
168DNA duplex unwinding (GO:0032508)2.30049232
169histone H3-K9 demethylation (GO:0033169)2.29722282
170DNA geometric change (GO:0032392)2.29655728
171mannose metabolic process (GO:0006013)2.28789229
172meiotic chromosome segregation (GO:0045132)2.27206244
173histone H2A monoubiquitination (GO:0035518)2.26977925

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.00188970
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.18401137
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.22621513
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.82877303
5MYC_22102868_ChIP-Seq_BL_Human3.41270035
6* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.26140299
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.06123659
8BP1_19119308_ChIP-ChIP_Hs578T_Human2.99632324
9* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.97042214
10* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.85716220
11BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.69433518
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.62828642
13* VDR_21846776_ChIP-Seq_THP-1_Human2.60357949
14FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.48964714
15FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.25982274
16SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23103121
17STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.17974478
18TCF7_22412390_ChIP-Seq_EML_Mouse2.16772319
19E2F1_21310950_ChIP-Seq_MCF-7_Human2.11134781
20MYB_26560356_Chip-Seq_TH2_Human2.08921622
21BRD4_27068464_Chip-Seq_AML-cells_Mouse2.07832230
22GATA1_22025678_ChIP-Seq_K562_Human2.05287262
23ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.04962698
24KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.01879340
25IRF8_21731497_ChIP-ChIP_J774_Mouse1.99473862
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.99431977
27AR_21909140_ChIP-Seq_LNCAP_Human1.97381118
28MYB_26560356_Chip-Seq_TH1_Human1.96688607
29SCL_19346495_ChIP-Seq_HPC-7_Human1.96223888
30* IRF8_27001747_Chip-Seq_BMDM_Mouse1.94304305
31* UTX_26944678_Chip-Seq_JUKART_Human1.93235019
32* VDR_24787735_ChIP-Seq_THP-1_Human1.93047300
33STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.92703110
34MAF_26560356_Chip-Seq_TH1_Human1.91962318
35TP63_19390658_ChIP-ChIP_HaCaT_Human1.86834952
36SPI1_23547873_ChIP-Seq_NB4_Human1.86659604
37KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.85183991
38* VDR_24763502_ChIP-Seq_THP-1_Human1.83715723
39* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.76708875
40SPI1_23127762_ChIP-Seq_K562_Human1.72492714
41RUNX_20019798_ChIP-Seq_JUKART_Human1.69530782
42KDM2B_26808549_Chip-Seq_DND41_Human1.64248198
43SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.62865372
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.60974182
45IRF8_22096565_ChIP-ChIP_GC-B_Human1.59501489
46SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.53625513
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.53541147
48CIITA_25753668_ChIP-Seq_RAJI_Human1.47818588
49FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43036566
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.38156802
51GATA1_19941827_ChIP-Seq_MEL_Mouse1.37726301
52KDM2B_26808549_Chip-Seq_SUP-B15_Human1.37644097
53* GATA3_27048872_Chip-Seq_THYMUS_Human1.36261816
54GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32455503
55IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.30591661
56E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29254544
57RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.26791461
58IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.25942511
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25914684
60* KDM2B_26808549_Chip-Seq_JURKAT_Human1.25676001
61GATA2_21666600_ChIP-Seq_HMVEC_Human1.25462719
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.25256116
63PU_27001747_Chip-Seq_BMDM_Mouse1.23722466
64SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19043410
65MAF_26560356_Chip-Seq_TH2_Human1.15346040
66PKCTHETA_26484144_Chip-Seq_BREAST_Human1.14868233
67NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.14217629
68KDM5A_27292631_Chip-Seq_BREAST_Human1.12877769
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11618362
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.10115637
71SALL1_21062744_ChIP-ChIP_HESCs_Human1.10002262
72MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08286617
73GATA2_19941826_ChIP-Seq_K562_Human1.05054127
74TP53_16413492_ChIP-PET_HCT116_Human1.04364252
75FOXO3_23340844_ChIP-Seq_DLD1_Human1.03688997
76Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.00443729
77GATA2_22383799_ChIP-Seq_G1ME_Mouse1.00097125
78FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99582168
79* NCOR1_26117541_ChIP-Seq_K562_Human0.99437862
80TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99043666
81* GATA1_19941827_ChIP-Seq_MEL86_Mouse0.97856362
82CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97085223
83GATA1_19941826_ChIP-Seq_K562_Human0.96603759
84* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.95397266
85MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.95381856
86KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.92950950
87RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.92486415
88ESR1_20079471_ChIP-ChIP_T-47D_Human0.92178085
89CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90227485
90GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89954662
91* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.89519613
92SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88501512
93* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.88463299
94BRD4_25478319_ChIP-Seq_HGPS_Human0.87946539
95SMRT_27268052_Chip-Seq_Bcells_Human0.87385735
96AHR_22903824_ChIP-Seq_MCF-7_Human0.87355406
97* TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.86330229
98PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.86257716
99HOXB4_20404135_ChIP-ChIP_EML_Mouse0.86051079
100ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84666560
101GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.84483825
102CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83895673
103RBPJ_22232070_ChIP-Seq_NCS_Mouse0.83082143
104* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.81945230
105FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80017989
106GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78899622
107RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78899187
108* CDX2_19796622_ChIP-Seq_MESCs_Mouse0.78662543
109CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.78618718
110NOTCH1_21737748_ChIP-Seq_TLL_Human0.78396282
111TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.78375880
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.77428829
113* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77372325
114CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.76412101
115* GATA3_26560356_Chip-Seq_TH2_Human0.76405385
116CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.76395716
117* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.76366688
118* ARNT_22903824_ChIP-Seq_MCF-7_Human0.74761797
119* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.74720151
120FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.74682583
121MYCN_18555785_ChIP-Seq_MESCs_Mouse0.74446411
122PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74384197
123AR_21572438_ChIP-Seq_LNCaP_Human0.72969172
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.71576537
125UBF1/2_26484160_Chip-Seq_HMECs_Human0.70919118
126SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.70356621
127SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.70356621
128* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.69863737
129* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.69684389
130CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.69129176
131SOX9_24532713_ChIP-Seq_HFSC_Mouse0.68798742
132PRDM14_20953172_ChIP-Seq_ESCs_Human0.68234795
133POU3F2_20337985_ChIP-ChIP_501MEL_Human0.67933293
134LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.66710606

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003303_peritoneal_inflammation3.86808809
2MP0003724_increased_susceptibility_to3.39458019
3MP0002396_abnormal_hematopoietic_system3.23056423
4MP0003693_abnormal_embryo_hatching3.13902017
5MP0004808_abnormal_hematopoietic_stem2.82858090
6MP0000569_abnormal_digit_pigmentation2.74874419
7MP0009278_abnormal_bone_marrow2.59762687
8MP0003111_abnormal_nucleus_morphology2.54657510
9MP0010307_abnormal_tumor_latency2.46274108
10MP0010094_abnormal_chromosome_stability2.45066955
11MP0008260_abnormal_autophagy2.32592703
12MP0003077_abnormal_cell_cycle2.24716000
13MP0002166_altered_tumor_susceptibility2.22590091
14MP0003300_gastrointestinal_ulcer2.21881630
15MP0004381_abnormal_hair_follicle2.21072108
16MP0005397_hematopoietic_system_phenotyp2.19763668
17MP0001545_abnormal_hematopoietic_system2.19763668
18MP0008057_abnormal_DNA_replication2.09404320
19MP0002006_tumorigenesis1.97264256
20MP0005076_abnormal_cell_differentiation1.94963860
21MP0005451_abnormal_body_composition1.93549370
22MP0002398_abnormal_bone_marrow1.87061412
23MP0003436_decreased_susceptibility_to1.87010245
24MP0003763_abnormal_thymus_physiology1.82170527
25MP0001835_abnormal_antigen_presentation1.80610174
26MP0001800_abnormal_humoral_immune1.76272848
27MP0000465_gastrointestinal_hemorrhage1.75658539
28MP0003172_abnormal_lysosome_physiology1.74847854
29MP0002419_abnormal_innate_immunity1.70568774
30MP0002452_abnormal_antigen_presenting1.69698294
31MP0002877_abnormal_melanocyte_morpholog1.69368724
32MP0002420_abnormal_adaptive_immunity1.68848967
33MP0004883_abnormal_blood_vessel1.66821683
34MP0001819_abnormal_immune_cell1.65907076
35MP0010352_gastrointestinal_tract_polyps1.65386023
36MP0003787_abnormal_imprinting1.64636536
37MP0000703_abnormal_thymus_morphology1.62437585
38MP0003183_abnormal_peptide_metabolism1.60513172
39MP0000716_abnormal_immune_system1.52357207
40MP0002405_respiratory_system_inflammati1.51871663
41MP0002722_abnormal_immune_system1.49168853
42MP0000350_abnormal_cell_proliferation1.48768768
43MP0002148_abnormal_hypersensitivity_rea1.48212313
44MP0005464_abnormal_platelet_physiology1.46978087
45MP0005075_abnormal_melanosome_morpholog1.45252120
46MP0005174_abnormal_tail_pigmentation1.44166201
47MP0005671_abnormal_response_to1.43281876
48MP0004957_abnormal_blastocyst_morpholog1.43096201
49MP0002723_abnormal_immune_serum1.42963514
50MP0000689_abnormal_spleen_morphology1.40606301
51MP0001851_eye_inflammation1.40143746
52MP0005000_abnormal_immune_tolerance1.37723498
53MP0002009_preneoplasia1.36342386
54MP0000733_abnormal_muscle_development1.34871877
55MP0009333_abnormal_splenocyte_physiolog1.34764668
56MP0003191_abnormal_cellular_cholesterol1.34258864
57MP0000685_abnormal_immune_system1.33807235
58MP0003705_abnormal_hypodermis_morpholog1.33391899
59MP0003866_abnormal_defecation1.33089131
60MP0006082_CNS_inflammation1.32512114
61MP0005387_immune_system_phenotype1.31818372
62MP0001790_abnormal_immune_system1.31818372
63MP0001730_embryonic_growth_arrest1.30961773
64MP0002429_abnormal_blood_cell1.29883315
65MP0008007_abnormal_cellular_replicative1.28794485
66MP0000490_abnormal_crypts_of1.28103578
67MP0001873_stomach_inflammation1.26605138
68MP0003566_abnormal_cell_adhesion1.24834077
69MP0003656_abnormal_erythrocyte_physiolo1.23767087
70MP0000015_abnormal_ear_pigmentation1.22777791
71MP0003121_genomic_imprinting1.21026485
72MP0002998_abnormal_bone_remodeling1.17063054
73MP0001672_abnormal_embryogenesis/_devel1.16313291
74MP0005380_embryogenesis_phenotype1.16313291
75MP0003828_pulmonary_edema1.16251209
76MP0005025_abnormal_response_to1.14757018
77MP0003984_embryonic_growth_retardation1.13715951
78MP0003123_paternal_imprinting1.12365042
79MP0003448_altered_tumor_morphology1.10705616
80MP0002019_abnormal_tumor_incidence1.09502675
81MP0002088_abnormal_embryonic_growth/wei1.09173980
82MP0005164_abnormal_response_to1.07931033
83MP0005310_abnormal_salivary_gland1.06924869
84MP0003690_abnormal_glial_cell1.04797252
85MP0008058_abnormal_DNA_repair1.04452060
86MP0005409_darkened_coat_color1.02941647
87MP0003091_abnormal_cell_migration1.02871108
88MP0002086_abnormal_extraembryonic_tissu1.01430218
89MP0002095_abnormal_skin_pigmentation1.00592298
90MP0008877_abnormal_DNA_methylation0.97321707
91MP0001533_abnormal_skeleton_physiology0.96333769
92MP0005621_abnormal_cell_physiology0.94505572
93MP0001697_abnormal_embryo_size0.94377472
94MP0010155_abnormal_intestine_physiology0.93616448
95MP0003045_fibrosis0.91762059
96MP0002925_abnormal_cardiovascular_devel0.86688696
97MP0002332_abnormal_exercise_endurance0.86270358
98MP0001845_abnormal_inflammatory_respons0.85063580
99MP0002080_prenatal_lethality0.84480179
100MP0004130_abnormal_muscle_cell0.84062899
101MP0002084_abnormal_developmental_patter0.82941503
102MP0000313_abnormal_cell_death0.81892295
103MP0004947_skin_inflammation0.81705544
104MP0009764_decreased_sensitivity_to0.81537765
105MP0003567_abnormal_fetal_cardiomyocyte0.81308855
106MP0002132_abnormal_respiratory_system0.80678763
107MP0000858_altered_metastatic_potential0.78643623
108MP0001853_heart_inflammation0.78386838
109MP0002085_abnormal_embryonic_tissue0.77800617
110MP0004510_myositis0.77234794
111MP0008469_abnormal_protein_level0.77232469
112MP0000371_diluted_coat_color0.75892429
113MP0009785_altered_susceptibility_to0.75682702
114MP0005023_abnormal_wound_healing0.74529815
115MP0009703_decreased_birth_body0.74527620
116MP0005384_cellular_phenotype0.73614324
117MP0000249_abnormal_blood_vessel0.72668391
118MP0001915_intracranial_hemorrhage0.72561400
119MP0010630_abnormal_cardiac_muscle0.72448930
120MP0009115_abnormal_fat_cell0.69921608
121MP0000767_abnormal_smooth_muscle0.69569644
122MP0010386_abnormal_urinary_bladder0.68772642
123MP0004197_abnormal_fetal_growth/weight/0.67171444
124MP0004484_altered_response_of0.66441332
125MP0004185_abnormal_adipocyte_glucose0.65991188
126MP0003221_abnormal_cardiomyocyte_apopto0.65263974
127MP0001958_emphysema0.64079266
128MP0000604_amyloidosis0.62788440
129MP0002928_abnormal_bile_duct0.61854608
130MP0005408_hypopigmentation0.60711487
131MP0003453_abnormal_keratinocyte_physiol0.59961230
132MP0002133_abnormal_respiratory_system0.56491813
133MP0005388_respiratory_system_phenotype0.56491813
134MP0009763_increased_sensitivity_to0.56318637

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of T cell number (HP:0011839)4.08825635
2Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.79278676
3Recurrent abscess formation (HP:0002722)3.75510385
4Eczematoid dermatitis (HP:0000976)3.69638534
5Abnormality of the fingertips (HP:0001211)3.58025871
6Recurrent bacterial skin infections (HP:0005406)3.31240393
7Optic neuritis (HP:0100653)3.28994577
8Retrobulbar optic neuritis (HP:0100654)3.28994577
9Orchitis (HP:0100796)3.20492441
10Gastrointestinal infarctions (HP:0005244)3.09991246
11Panhypogammaglobulinemia (HP:0003139)3.00824142
12Recurrent fungal infections (HP:0002841)2.99070556
13Colitis (HP:0002583)2.89266558
14Abnormality of macrophages (HP:0004311)2.87950741
15Abnormality of T cells (HP:0002843)2.84288623
16Vasculitis (HP:0002633)2.81085772
17Obstructive lung disease (HP:0006536)2.80711128
18Chronic obstructive pulmonary disease (HP:0006510)2.80711128
19Acute myeloid leukemia (HP:0004808)2.75875307
20Gingival bleeding (HP:0000225)2.75633590
21Recurrent viral infections (HP:0004429)2.72215373
22Volvulus (HP:0002580)2.71375140
23Elevated erythrocyte sedimentation rate (HP:0003565)2.71134178
24Agammaglobulinemia (HP:0004432)2.70131244
25Cellulitis (HP:0100658)2.68273961
26Absent frontal sinuses (HP:0002688)2.67548582
27Inflammation of the large intestine (HP:0002037)2.66536456
28Encephalitis (HP:0002383)2.63498842
29Recurrent bronchitis (HP:0002837)2.60296699
30Cerebral aneurysm (HP:0004944)2.58575408
31Stomatitis (HP:0010280)2.58391996
32Gastrointestinal inflammation (HP:0004386)2.56012172
33Keratoconjunctivitis sicca (HP:0001097)2.54993180
34Lip pit (HP:0100267)2.44848287
35Epistaxis (HP:0000421)2.44842127
36Increased IgE level (HP:0003212)2.43025814
37Chromsome breakage (HP:0040012)2.41591844
38Papilledema (HP:0001085)2.39545790
39Long clavicles (HP:0000890)2.37483877
40Long eyelashes (HP:0000527)2.36210297
41Mediastinal lymphadenopathy (HP:0100721)2.33580755
42Entropion (HP:0000621)2.31595724
43Slow saccadic eye movements (HP:0000514)2.30755143
44Pulmonary infiltrates (HP:0002113)2.29258831
45Peritonitis (HP:0002586)2.28795883
46Short 4th metacarpal (HP:0010044)2.26756797
47Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.26756797
48Urticaria (HP:0001025)2.26440149
49Osteolytic defects of the hand bones (HP:0009699)2.26047383
50Osteolytic defects of the phalanges of the hand (HP:0009771)2.26047383
51Facial hemangioma (HP:0000329)2.24872559
52Syringomyelia (HP:0003396)2.24260376
53Spinal cord lesions (HP:0100561)2.24260376
54Keratoconjunctivitis (HP:0001096)2.23534824
55High pitched voice (HP:0001620)2.22781619
56IgM deficiency (HP:0002850)2.22049737
57Asymmetry of the thorax (HP:0001555)2.21661357
58Granulocytopenia (HP:0001913)2.21346367
59Autoimmune hemolytic anemia (HP:0001890)2.21096924
60Hypoplasia of the thymus (HP:0000778)2.19084141
61Sepsis (HP:0100806)2.17742624
62Increased density of long bones (HP:0006392)2.17162280
63Difficulty running (HP:0009046)2.15745176
64Hemoptysis (HP:0002105)2.14793742
65Thrombocytosis (HP:0001894)2.14597829
66Hyperacusis (HP:0010780)2.13456551
67Abnormal delayed hypersensitivity skin test (HP:0002963)2.12811346
68Abnormality of cells of the lymphoid lineage (HP:0012140)2.12219128
69Abnormal platelet volume (HP:0011876)2.12035718
70IgA deficiency (HP:0002720)2.11490953
71* Prominent nose (HP:0000448)2.10538836
72Papillary thyroid carcinoma (HP:0002895)2.09604903
73Chromosomal breakage induced by crosslinking agents (HP:0003221)2.09135274
74Abnormality of the peritoneum (HP:0002585)2.09003341
75Ulnar bowing (HP:0003031)2.05395281
76Recurrent gram-negative bacterial infections (HP:0005420)2.04567068
77Deep philtrum (HP:0002002)2.02257865
78Meningitis (HP:0001287)2.00018881
79Recurrent cutaneous fungal infections (HP:0011370)1.96589655
80Chronic mucocutaneous candidiasis (HP:0002728)1.96589655
81Abnormality of eosinophils (HP:0001879)1.95431888
82Gingivitis (HP:0000230)1.94925749
83Conjunctival telangiectasia (HP:0000524)1.94866085
84Myositis (HP:0100614)1.94750488
85Spontaneous hematomas (HP:0007420)1.94724266
86Hematochezia (HP:0002573)1.94423138
87Recurrent skin infections (HP:0001581)1.94135616
88Increased nuchal translucency (HP:0010880)1.93356122
89Gastrointestinal stroma tumor (HP:0100723)1.93080610
90Chest pain (HP:0100749)1.92449647
91Abnormality of the vasculature of the conjunctiva (HP:0008054)1.91393531
92Cutaneous melanoma (HP:0012056)1.90334991
93Thyroiditis (HP:0100646)1.90263566
94Abnormality of T cell physiology (HP:0011840)1.90091104
95Pustule (HP:0200039)1.89788620
96Acute lymphatic leukemia (HP:0006721)1.89661555
97Pulmonary embolism (HP:0002204)1.89061415
98Periodontitis (HP:0000704)1.87847272
99Myelodysplasia (HP:0002863)1.86879673
100Abnormality of chromosome stability (HP:0003220)1.84476034
101Abnormality of the prostate (HP:0008775)1.83763582
102Chronic otitis media (HP:0000389)1.82744001
103Neoplasm of the tracheobronchial system (HP:0100552)1.82444978
104Heterotopia (HP:0002282)1.82047186
105Abnormality of the thoracic spine (HP:0100711)1.82037536
106Severe combined immunodeficiency (HP:0004430)1.81158383
107Fatigue (HP:0012378)1.81096741
108Spondylolisthesis (HP:0003302)1.80776008
109Ocular albinism (HP:0001107)1.79843367
110Enlarged penis (HP:0000040)1.79517916
111Flared metaphyses (HP:0003015)1.77794586
112Disinhibition (HP:0000734)1.77265043
113Arterial thrombosis (HP:0004420)1.76999875
114B lymphocytopenia (HP:0010976)1.76997242
115Abnormality of B cell number (HP:0010975)1.76997242
116Amaurosis fugax (HP:0100576)1.76611711
117Eosinophilia (HP:0001880)1.75777359
118Narrow palate (HP:0000189)1.75567928
119Increased mean platelet volume (HP:0011877)1.75161564
120Chronic diarrhea (HP:0002028)1.74288546
121Truncal obesity (HP:0001956)1.73916515
122Recurrent sinusitis (HP:0011108)1.73832111
123Ectopic kidney (HP:0000086)1.73762536
124Prostate neoplasm (HP:0100787)1.73726530
125Osteomyelitis (HP:0002754)1.71963938
126Leukocytosis (HP:0001974)1.71839160
127Skin ulcer (HP:0200042)1.70039117
128Aplasia/Hypoplasia of the thymus (HP:0010515)1.69284162
129Recurrent pneumonia (HP:0006532)1.69220763
130Deviation of the thumb (HP:0009603)1.66956452
131Autoimmune thrombocytopenia (HP:0001973)1.66633941
132Vertebral arch anomaly (HP:0008438)1.65782098
133Verrucae (HP:0200043)1.65136529
134Papilloma (HP:0012740)1.65136529
135Wrist flexion contracture (HP:0001239)1.63074921
136Broad palm (HP:0001169)1.61894087
137T lymphocytopenia (HP:0005403)1.61856388
138Sandal gap (HP:0001852)1.61840116
139Birth length less than 3rd percentile (HP:0003561)1.61592089
140Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.60341168
141Abnormality of chromosome segregation (HP:0002916)1.58725274
142Urethral obstruction (HP:0000796)1.58395483
143Subacute progressive viral hepatitis (HP:0006572)1.57606055
144Impulsivity (HP:0100710)1.57300136
145Prolonged bleeding time (HP:0003010)1.56903297
146Transitional cell carcinoma of the bladder (HP:0006740)1.56231726
147Cutis marmorata (HP:0000965)1.55014841
148Proximal placement of thumb (HP:0009623)1.54902748
149Radial bowing (HP:0002986)1.54731799
150Lymphopenia (HP:0001888)1.52324182
151Ureteral stenosis (HP:0000071)1.52168991
152Inappropriate behavior (HP:0000719)1.51834957
153Macroorchidism (HP:0000053)1.51830245
154Limited elbow extension (HP:0001377)1.50692055
155Viral hepatitis (HP:0006562)1.50252739

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EEF2K3.27114499
2CDC73.08316554
3NEK22.90727076
4MAP4K12.83643413
5CDK122.70262746
6LATS12.62747731
7STK102.48175382
8PRPF4B2.32319722
9TRIB32.24907754
10PKN22.13843824
11TTN2.06313729
12DMPK1.89279417
13TAOK31.85711785
14IKBKE1.81813751
15SIK21.79987106
16STK31.78771909
17BMPR21.78129505
18RIPK41.75031828
19IRAK41.66989612
20FGR1.59045539
21NUAK11.54596037
22CAMK1G1.53699207
23PIK3CG1.53145195
24FES1.50791255
25CAMK1D1.45259074
26TRPM71.41655759
27GRK61.39417724
28TEC1.37190442
29PLK41.35056963
30ALK1.33607935
31TAOK11.33583827
32CDK61.30936070
33WNK11.29689027
34NEK91.29650524
35FGFR31.28424619
36STK41.27585345
37YES11.23699303
38MAP3K61.23355467
39BTK1.21840532
40CDK41.20619119
41IRAK11.20601014
42MAP3K21.19948055
43RPS6KA41.13981100
44ITK1.13893134
45HCK1.12842214
46JAK31.11905406
47LRRK21.11424771
48TYK21.10798281
49PIM11.09663076
50MARK31.07927508
51IRAK21.07656992
52TXK1.06410200
53ATR1.05701262
54MARK21.05604942
55JAK11.05112828
56TTK1.03811244
57CLK11.03733135
58WEE10.99329357
59NLK0.99226115
60MAP3K100.98250495
61MAP2K30.97807194
62CHEK10.97739927
63CSK0.96956616
64AURKB0.96806371
65MAP3K80.95683199
66CHEK20.94746700
67CAMKK20.92763719
68KSR20.91686655
69MAP3K10.90470619
70RAF10.88396026
71ZAP700.86950563
72PDGFRB0.84838299
73SCYL20.84528754
74FGFR40.83311773
75SGK30.80782003
76MAP3K70.80419181
77RIPK10.79459105
78MKNK10.78442791
79TGFBR20.78317913
80MELK0.78285286
81SYK0.77889923
82MATK0.77732484
83BRD40.77564483
84PLK10.77131807
85PLK30.77039626
86MAP3K30.74410910
87KIT0.73164031
88TBK10.72469264
89RET0.71577835
90PTK2B0.71514298
91CDK90.70975779
92SRPK10.70943994
93MKNK20.69997648
94MAPK70.68905763
95CSF1R0.68193003
96ERN10.68052726
97BRSK20.68036283
98ATM0.67958956
99KSR10.67352383
100MAP3K130.66353821
101STK110.66135408
102FRK0.65466473
103SGK4940.64566445
104SGK2230.64566445
105LATS20.64119376
106MTOR0.62738042
107MAPK120.62361049
108IKBKB0.62016600
109CDK20.61992533
110TNK20.60806175
111MAP3K50.58414763
112CDK70.57345602
113LCK0.57273294
114STK240.56511982
115BLK0.56288466
116CAMKK10.56141541
117JAK20.56092314
118ABL10.55300501
119ERBB30.55141705
120PTK60.54684803
121PRKCQ0.54309644
122ZAK0.53566836
123PRKCH0.52437429
124MAP2K40.52218160
125FYN0.52068416
126CAMK40.52032600
127CHUK0.50760151
128CDC42BPA0.48452698
129MAPK110.47868041
130SGK20.47299819
131CSNK1A1L0.45864901
132SGK10.44946237
133MAP3K140.44180779
134LYN0.44164013
135BMX0.42945550
136RPS6KA20.42184907
137PDPK10.42095977
138CDK10.42082637
139EPHB10.41678512
140RPS6KB20.41563196
141PDK10.40344417
142MAPK140.38923334
143HIPK20.38485780

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041101.77545433
2B cell receptor signaling pathway_Homo sapiens_hsa046621.76094537
3Leishmaniasis_Homo sapiens_hsa051401.67176904
4Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.59880331
5Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.59616606
6Allograft rejection_Homo sapiens_hsa053301.58799415
7Graft-versus-host disease_Homo sapiens_hsa053321.56086583
8Osteoclast differentiation_Homo sapiens_hsa043801.53635033
9Staphylococcus aureus infection_Homo sapiens_hsa051501.53335207
10Chronic myeloid leukemia_Homo sapiens_hsa052201.52740164
11Autoimmune thyroid disease_Homo sapiens_hsa053201.47521099
12RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.36606698
13Pancreatic cancer_Homo sapiens_hsa052121.34992770
14Non-small cell lung cancer_Homo sapiens_hsa052231.34801389
15Leukocyte transendothelial migration_Homo sapiens_hsa046701.30527558
16Primary immunodeficiency_Homo sapiens_hsa053401.29557816
17Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.29517414
18Small cell lung cancer_Homo sapiens_hsa052221.29423359
19Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27764893
20Platelet activation_Homo sapiens_hsa046111.25696838
21DNA replication_Homo sapiens_hsa030301.24387754
22T cell receptor signaling pathway_Homo sapiens_hsa046601.23694395
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.23163213
24Malaria_Homo sapiens_hsa051441.22710943
25Chemokine signaling pathway_Homo sapiens_hsa040621.21461865
26MicroRNAs in cancer_Homo sapiens_hsa052061.20373415
27mTOR signaling pathway_Homo sapiens_hsa041501.20105240
28RNA transport_Homo sapiens_hsa030131.19435760
29Hepatitis B_Homo sapiens_hsa051611.19162249
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.19135917
31Toxoplasmosis_Homo sapiens_hsa051451.18259845
32Viral myocarditis_Homo sapiens_hsa054161.17614467
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.15305176
34Antigen processing and presentation_Homo sapiens_hsa046121.13116989
35Colorectal cancer_Homo sapiens_hsa052101.10619000
36Neurotrophin signaling pathway_Homo sapiens_hsa047221.10540050
37p53 signaling pathway_Homo sapiens_hsa041151.10514090
38Measles_Homo sapiens_hsa051621.08157292
39mRNA surveillance pathway_Homo sapiens_hsa030151.07152551
40Herpes simplex infection_Homo sapiens_hsa051681.06693232
41Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.05615933
42Hepatitis C_Homo sapiens_hsa051601.05322963
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05181128
44VEGF signaling pathway_Homo sapiens_hsa043701.04391519
45Fanconi anemia pathway_Homo sapiens_hsa034601.03864827
46Acute myeloid leukemia_Homo sapiens_hsa052211.03495583
47Hematopoietic cell lineage_Homo sapiens_hsa046401.03279396
48Tuberculosis_Homo sapiens_hsa051521.02908429
49Shigellosis_Homo sapiens_hsa051311.02580355
50Olfactory transduction_Homo sapiens_hsa047401.01519076
51Intestinal immune network for IgA production_Homo sapiens_hsa046721.01341088
52Legionellosis_Homo sapiens_hsa051341.01016828
53Glioma_Homo sapiens_hsa052141.00618255
54HTLV-I infection_Homo sapiens_hsa051661.00569082
55Apoptosis_Homo sapiens_hsa042100.99131324
56Viral carcinogenesis_Homo sapiens_hsa052030.99012764
57Type I diabetes mellitus_Homo sapiens_hsa049400.98339430
58Jak-STAT signaling pathway_Homo sapiens_hsa046300.98302192
59Thyroid hormone signaling pathway_Homo sapiens_hsa049190.96744413
60Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.96243518
61FoxO signaling pathway_Homo sapiens_hsa040680.95679127
62ErbB signaling pathway_Homo sapiens_hsa040120.93985622
63Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.92170724
64Endometrial cancer_Homo sapiens_hsa052130.91504892
65Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.91064705
66TNF signaling pathway_Homo sapiens_hsa046680.89933080
67Spliceosome_Homo sapiens_hsa030400.89641982
68Prostate cancer_Homo sapiens_hsa052150.89624953
69Toll-like receptor signaling pathway_Homo sapiens_hsa046200.89119063
70Base excision repair_Homo sapiens_hsa034100.87774055
71Epstein-Barr virus infection_Homo sapiens_hsa051690.87424875
72Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86718094
73Renal cell carcinoma_Homo sapiens_hsa052110.86591237
74Oocyte meiosis_Homo sapiens_hsa041140.85464371
75Influenza A_Homo sapiens_hsa051640.84912812
76Dorso-ventral axis formation_Homo sapiens_hsa043200.84126255
77Prolactin signaling pathway_Homo sapiens_hsa049170.82411929
78Proteoglycans in cancer_Homo sapiens_hsa052050.81905648
79Vitamin B6 metabolism_Homo sapiens_hsa007500.81710893
80Non-homologous end-joining_Homo sapiens_hsa034500.81455776
81Homologous recombination_Homo sapiens_hsa034400.80384549
82Phagosome_Homo sapiens_hsa041450.80076591
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.79859451
84Focal adhesion_Homo sapiens_hsa045100.79260538
85GnRH signaling pathway_Homo sapiens_hsa049120.78053754
86RNA degradation_Homo sapiens_hsa030180.75212536
87Long-term potentiation_Homo sapiens_hsa047200.74426998
88HIF-1 signaling pathway_Homo sapiens_hsa040660.73711172
89Estrogen signaling pathway_Homo sapiens_hsa049150.73296138
90Inositol phosphate metabolism_Homo sapiens_hsa005620.72311885
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.71935049
92Adherens junction_Homo sapiens_hsa045200.70871929
93Salmonella infection_Homo sapiens_hsa051320.70420634
94Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.70376910
95Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.70367717
96MAPK signaling pathway_Homo sapiens_hsa040100.68797696
97Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.68743421
98Asthma_Homo sapiens_hsa053100.64903209
99Type II diabetes mellitus_Homo sapiens_hsa049300.63966089
100Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63456868
101Notch signaling pathway_Homo sapiens_hsa043300.63333532
102Longevity regulating pathway - mammal_Homo sapiens_hsa042110.63024540
103Choline metabolism in cancer_Homo sapiens_hsa052310.62755246
104Pertussis_Homo sapiens_hsa051330.62714380
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.62513505
106Rap1 signaling pathway_Homo sapiens_hsa040150.62107062
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.61780598
108Pathways in cancer_Homo sapiens_hsa052000.61548362
109African trypanosomiasis_Homo sapiens_hsa051430.60471118
110Amoebiasis_Homo sapiens_hsa051460.60400135
111Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.59675080
112Thyroid cancer_Homo sapiens_hsa052160.59521838
113Insulin resistance_Homo sapiens_hsa049310.59215793
114Phospholipase D signaling pathway_Homo sapiens_hsa040720.59144469
115Other glycan degradation_Homo sapiens_hsa005110.58899598
116Lysine degradation_Homo sapiens_hsa003100.58133105
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.57963709
118Endocytosis_Homo sapiens_hsa041440.55356176
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52451573
120Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51890602
121Ras signaling pathway_Homo sapiens_hsa040140.50227472

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