NINJ1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The ninjurin protein is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells (Araki and Milbrandt, 1996 [PubMed 8780658]). It demonstrates properties of a homophilic adhesion molecule and promotes neurite outgrowth from primary cultured dorsal root ganglion neurons. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of interleukin-12 production (GO:0032695)5.34141999
2L-phenylalanine catabolic process (GO:0006559)4.66002670
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.66002670
4L-phenylalanine metabolic process (GO:0006558)4.55777125
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.55777125
6macrophage activation involved in immune response (GO:0002281)4.39043397
7aromatic amino acid family catabolic process (GO:0009074)4.21416364
8lipopolysaccharide-mediated signaling pathway (GO:0031663)4.14396485
9negative regulation of cell killing (GO:0031342)4.05029015
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.05029015
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.03888229
12positive regulation of gamma-delta T cell activation (GO:0046645)4.03164122
13complement activation, alternative pathway (GO:0006957)3.97186174
14regulation of vitamin D biosynthetic process (GO:0060556)3.95530009
15NIK/NF-kappaB signaling (GO:0038061)3.84840090
16indole-containing compound catabolic process (GO:0042436)3.82205213
17indolalkylamine catabolic process (GO:0046218)3.82205213
18tryptophan catabolic process (GO:0006569)3.82205213
19peptidyl-glutamic acid carboxylation (GO:0017187)3.79610126
20protein carboxylation (GO:0018214)3.79610126
21glyoxylate metabolic process (GO:0046487)3.72860671
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.70326188
23negative regulation of cytokine production involved in immune response (GO:0002719)3.68750478
24tryptophan metabolic process (GO:0006568)3.66732222
25aldehyde catabolic process (GO:0046185)3.66292863
26cellular response to type I interferon (GO:0071357)3.65221405
27type I interferon signaling pathway (GO:0060337)3.65221405
28kynurenine metabolic process (GO:0070189)3.65073815
29antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.64232755
30plasma lipoprotein particle clearance (GO:0034381)3.61814570
31regulation of T-helper 1 cell differentiation (GO:0045625)3.60420777
32response to type I interferon (GO:0034340)3.60234264
33urea metabolic process (GO:0019627)3.59938269
34urea cycle (GO:0000050)3.59938269
35bile acid biosynthetic process (GO:0006699)3.58775114
36sulfur amino acid catabolic process (GO:0000098)3.56635110
37T-helper 1 type immune response (GO:0042088)3.55830395
38cysteine metabolic process (GO:0006534)3.53924036
39granulocyte activation (GO:0036230)3.53468182
40alpha-linolenic acid metabolic process (GO:0036109)3.46104898
41myeloid dendritic cell differentiation (GO:0043011)3.45649481
42germinal center formation (GO:0002467)3.45286744
43detection of molecule of bacterial origin (GO:0032490)3.43698042
44positive regulation of chemokine biosynthetic process (GO:0045080)3.43205443
45positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.41956378
46regulation of podosome assembly (GO:0071801)3.41655141
47interferon-gamma-mediated signaling pathway (GO:0060333)3.40517336
48antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.40209238
49antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.40209238
50detection of other organism (GO:0098543)3.38228154
51regulation of cytokine secretion involved in immune response (GO:0002739)3.37906588
52regulation of protein activation cascade (GO:2000257)3.37164278
53nitrogen cycle metabolic process (GO:0071941)3.36027288
54defense response to protozoan (GO:0042832)3.35237186
55regulation of mononuclear cell migration (GO:0071675)3.33947757
56high-density lipoprotein particle remodeling (GO:0034375)3.33184353
57negative regulation of fibrinolysis (GO:0051918)3.29447896
58response to protozoan (GO:0001562)3.26244393
59positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.25001108
60neutrophil activation involved in immune response (GO:0002283)3.22302559
61regulation of complement activation (GO:0030449)3.21061542
62positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.21020033
63neutrophil activation (GO:0042119)3.20390434
64response to muramyl dipeptide (GO:0032495)3.20358787
65regulation of dendritic cell antigen processing and presentation (GO:0002604)3.18298715
66phospholipid efflux (GO:0033700)3.17763142
67detection of bacterium (GO:0016045)3.17211995
68regulation of cholesterol esterification (GO:0010872)3.16865894
69response to peptidoglycan (GO:0032494)3.15879997
70positive regulation of type 2 immune response (GO:0002830)3.14575249
71regulation of chemokine biosynthetic process (GO:0045073)3.13741630
72regulation of chronic inflammatory response (GO:0002676)3.12282252
73positive regulation of NF-kappaB import into nucleus (GO:0042346)3.12165440
74detection of external biotic stimulus (GO:0098581)3.11977416
75regulation of triglyceride catabolic process (GO:0010896)3.10898052
76regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.10807492
77regulation of vitamin metabolic process (GO:0030656)3.10574206
78myeloid cell activation involved in immune response (GO:0002275)3.09601329
79regulation of T cell tolerance induction (GO:0002664)3.08637358
80reverse cholesterol transport (GO:0043691)3.08073454
81myeloid dendritic cell activation (GO:0001773)3.07791710
82regulation of fibrinolysis (GO:0051917)3.07393092
83regulation of T-helper 2 cell differentiation (GO:0045628)3.06671584
84regulation of interleukin-12 production (GO:0032655)3.06016895
85macrophage activation (GO:0042116)3.05854307
86positive regulation by organism of defense response of other organism involved in symbiotic interact3.04756857
87modulation by symbiont of host immune response (GO:0052553)3.04756857
88positive regulation by symbiont of host defense response (GO:0052509)3.04756857
89modulation by symbiont of host defense response (GO:0052031)3.04756857
90modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.04756857
91modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.04756857
92immunoglobulin mediated immune response (GO:0016064)3.04321491
93positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.03479904
94plasma lipoprotein particle remodeling (GO:0034369)3.02275303
95protein-lipid complex remodeling (GO:0034368)3.02275303
96macromolecular complex remodeling (GO:0034367)3.02275303
97aromatic amino acid family metabolic process (GO:0009072)3.01652805
98lysine catabolic process (GO:0006554)3.01562281
99lysine metabolic process (GO:0006553)3.01562281
100cofactor catabolic process (GO:0051187)3.01496384
101disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.99305244
102killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.99305244
103regulation of antigen processing and presentation (GO:0002577)2.99260247
104regulation of mast cell degranulation (GO:0043304)2.99237080
105positive regulation of antigen processing and presentation (GO:0002579)2.99038964
106amino-acid betaine metabolic process (GO:0006577)2.98612057
107B cell mediated immunity (GO:0019724)2.97312125
108bile acid metabolic process (GO:0008206)2.97234149
109negative regulation of production of molecular mediator of immune response (GO:0002701)2.96442652
110antigen processing and presentation of endogenous antigen (GO:0019883)2.95985533
111positive regulation of interferon-alpha production (GO:0032727)2.95729957
112positive regulation of heat generation (GO:0031652)2.95547466
113respiratory burst (GO:0045730)2.94023040
114positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.93907605
115regulation of gamma-delta T cell activation (GO:0046643)2.93678549
116glycosphingolipid catabolic process (GO:0046479)2.92321892
117negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.91441504
118negative regulation of myeloid cell apoptotic process (GO:0033033)2.91070916
119acute-phase response (GO:0006953)2.90815522
120positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.90170273
121detection of biotic stimulus (GO:0009595)2.86141652
122urate metabolic process (GO:0046415)2.85990190
123low-density lipoprotein particle clearance (GO:0034383)2.85858487
124leukocyte aggregation (GO:0070486)2.85221150
125cellular extravasation (GO:0045123)2.83602033
126cellular response to lipopolysaccharide (GO:0071222)2.81591061
127positive regulation of lipoprotein lipase activity (GO:0051006)2.80435448
128positive regulation of triglyceride lipase activity (GO:0061365)2.80435448
129hydrogen peroxide biosynthetic process (GO:0050665)2.80268082
130NAD biosynthetic process (GO:0009435)2.79942101
131regulation of interferon-alpha production (GO:0032647)2.79629680
132regulation of fever generation (GO:0031620)2.79566279
133cellular response to molecule of bacterial origin (GO:0071219)2.78749281
134regulation of interleukin-8 biosynthetic process (GO:0045414)2.78577321
135tyrosine metabolic process (GO:0006570)2.78138632
136regulation of cholesterol storage (GO:0010885)2.77669371
137pyridine nucleotide biosynthetic process (GO:0019363)2.77230104
138nicotinamide nucleotide biosynthetic process (GO:0019359)2.77230104
139response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.76944596
140response to host immune response (GO:0052572)2.76944596
141lymphocyte chemotaxis (GO:0048247)2.76926548
142low-density lipoprotein particle remodeling (GO:0034374)2.76866551
143triglyceride homeostasis (GO:0070328)2.76837634
144acylglycerol homeostasis (GO:0055090)2.76837634
145regulation of tolerance induction (GO:0002643)2.76498843
146complement activation (GO:0006956)2.76035510
147response to interferon-beta (GO:0035456)2.75884842
148regulation of membrane protein ectodomain proteolysis (GO:0051043)2.75767459
149fibrinolysis (GO:0042730)2.75136524
150regulation of type 2 immune response (GO:0002828)2.74336174
151dendritic cell differentiation (GO:0097028)2.74308043
152cellular response to interferon-gamma (GO:0071346)2.74276210
153positive regulation of interleukin-10 production (GO:0032733)2.74273964
154negative regulation of cholesterol transport (GO:0032375)2.72390591
155negative regulation of sterol transport (GO:0032372)2.72390591
156plasma lipoprotein particle assembly (GO:0034377)2.72100907
157negative regulation of nitric oxide biosynthetic process (GO:0045019)2.71909700
158protein activation cascade (GO:0072376)2.71613202
159monocyte chemotaxis (GO:0002548)2.70977806
160regulation of mast cell activation involved in immune response (GO:0033006)2.70970944
161homocysteine metabolic process (GO:0050667)2.70941998
162cholesterol efflux (GO:0033344)2.70938858
163regulation of interferon-beta biosynthetic process (GO:0045357)2.70339868
164cellular biogenic amine catabolic process (GO:0042402)2.69809294
165amine catabolic process (GO:0009310)2.69809294
166serine family amino acid catabolic process (GO:0009071)2.69193546
167production of molecular mediator involved in inflammatory response (GO:0002532)2.67907445
168cellular response to thyroid hormone stimulus (GO:0097067)2.67801174
169valine metabolic process (GO:0006573)2.67744174
170microglial cell activation (GO:0001774)2.67722005
171positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.67330329
172complement activation, classical pathway (GO:0006958)2.65994967
173indolalkylamine metabolic process (GO:0006586)2.65692226
174oligosaccharide catabolic process (GO:0009313)2.65687881
175positive regulation of toll-like receptor signaling pathway (GO:0034123)2.65266816
176reactive oxygen species biosynthetic process (GO:1903409)2.65079985
177response to interferon-gamma (GO:0034341)2.64760819
178negative regulation of T cell mediated immunity (GO:0002710)2.63379495
179ethanol oxidation (GO:0006069)2.62218139
180arginine metabolic process (GO:0006525)2.58418963
181blood coagulation, intrinsic pathway (GO:0007597)2.57728785
182alpha-amino acid catabolic process (GO:1901606)2.57127641
183opsonization (GO:0008228)2.56733076

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.55453937
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.69024236
3* RXR_22158963_ChIP-Seq_LIVER_Mouse4.64930856
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.54553740
5* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.08187453
6EGR1_23403033_ChIP-Seq_LIVER_Mouse3.94400931
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.93357554
8* LXR_22158963_ChIP-Seq_LIVER_Mouse3.43884862
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.31723674
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.15814490
11IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.92676394
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.79617400
13* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.62316975
14IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.59627392
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.57119395
16CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.55441664
17* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.50664707
18MYB_21317192_ChIP-Seq_ERMYB_Mouse2.37844654
19MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.36319043
20FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.31547483
21NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.28338354
22* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.13251023
23RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.12289869
24* RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.03539783
25SCL_19346495_ChIP-Seq_HPC-7_Human2.00452084
26STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.91812221
27* VDR_24787735_ChIP-Seq_THP-1_Human1.76895313
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.74869342
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.73606349
30* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.71092942
31* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.69851685
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.66484507
33SPI1_23547873_ChIP-Seq_NB4_Human1.61373264
34VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.59332303
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58577538
36FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.58353834
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52846132
38STAT4_19710469_ChIP-ChIP_TH1__Mouse1.52844268
39* MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.51342916
40NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.49380319
41* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.45114817
42STAT6_21828071_ChIP-Seq_BEAS2B_Human1.44963364
43KDM2B_26808549_Chip-Seq_DND41_Human1.41226435
44GATA1_22025678_ChIP-Seq_K562_Human1.39441832
45KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36385734
46* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.35514727
47* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.35343702
48MAF_26560356_Chip-Seq_TH2_Human1.35034431
49* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.33253527
50ESR2_21235772_ChIP-Seq_MCF-7_Human1.32936120
51HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.31837049
52* RUNX1_22412390_ChIP-Seq_EML_Mouse1.30057822
53* VDR_24763502_ChIP-Seq_THP-1_Human1.29326859
54STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.27325702
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25031090
56* VDR_21846776_ChIP-Seq_THP-1_Human1.22573259
57* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.19549968
58NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.19022751
59GATA2_22383799_ChIP-Seq_G1ME_Mouse1.18019923
60* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.16903899
61TP63_17297297_ChIP-ChIP_HaCaT_Human1.16859203
62MAF_26560356_Chip-Seq_TH1_Human1.14422646
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.14152219
64BCL6_27268052_Chip-Seq_Bcells_Human1.13543793
65* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11455727
66PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10262918
67* SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.09375230
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.08941576
69PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06885752
70ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.06566486
71* CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.06413784
72PU_27001747_Chip-Seq_BMDM_Mouse1.05838858
73GATA2_21666600_ChIP-Seq_HMVEC_Human1.04803899
74MYB_26560356_Chip-Seq_TH2_Human1.04586644
75PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04397008
76EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.04191217
77* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04035105
78SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.03408075
79STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03093985
80KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02665657
81RACK7_27058665_Chip-Seq_MCF-7_Human1.02155934
82CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.01522654
83ELF1_17652178_ChIP-ChIP_JURKAT_Human0.99785626
84SPI1_23127762_ChIP-Seq_K562_Human0.99736699
85TFEB_21752829_ChIP-Seq_HELA_Human0.97840120
86STAT1_20625510_ChIP-Seq_HELA_Human0.97195938
87* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.97154298
88RARG_19884340_ChIP-ChIP_MEFs_Mouse0.97117840
89* GATA1_19941827_ChIP-Seq_MEL_Mouse0.96993239
90NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.96911775
91MYB_26560356_Chip-Seq_TH1_Human0.96397470
92VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.95734121
93TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.95568333
94ELF1_20517297_ChIP-Seq_JURKAT_Human0.94661606
95* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.91547562
96TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89670358
97SRF_21415370_ChIP-Seq_HL-1_Mouse0.88294364
98CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.87337719
99* ELK3_25401928_ChIP-Seq_HUVEC_Human0.86884034
100STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86353051
101GATA1_19941826_ChIP-Seq_K562_Human0.86336626
102* UTX_26944678_Chip-Seq_JUKART_Human0.84147487
103* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84035841
104* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84003604
105* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.82151609
106RUNX_20019798_ChIP-Seq_JUKART_Human0.80689825
107CLOCK_20551151_ChIP-Seq_293T_Human0.80140217
108ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.79669925
109* MYC_22102868_ChIP-Seq_BL_Human0.78519397
110PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78273998
111TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.77991911
112* LXR_22292898_ChIP-Seq_THP-1_Human0.77975563
113FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.77728695
114EGR1_19374776_ChIP-ChIP_THP-1_Human0.77538090
115GATA3_26560356_Chip-Seq_TH2_Human0.77174603
116GATA3_27048872_Chip-Seq_THYMUS_Human0.77110437
117BCOR_27268052_Chip-Seq_Bcells_Human0.76713991
118* TCF7_22412390_ChIP-Seq_EML_Mouse0.76636959
119GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76413407
120SPI1_20517297_ChIP-Seq_HL60_Human0.76264666
121RXRA_24833708_ChIP-Seq_LIVER_Mouse0.76021171

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.75179097
2MP0005360_urolithiasis4.22032526
3MP0005365_abnormal_bile_salt3.53007092
4MP0009840_abnormal_foam_cell3.42513403
5MP0005085_abnormal_gallbladder_physiolo3.28945961
6MP0003436_decreased_susceptibility_to2.83236017
7MP0008875_abnormal_xenobiotic_pharmacok2.80828959
8MP0003806_abnormal_nucleotide_metabolis2.66723239
9MP0003191_abnormal_cellular_cholesterol2.60553048
10MP0001835_abnormal_antigen_presentation2.50241512
11MP0005058_abnormal_lysosome_morphology2.48493116
12MP0009785_altered_susceptibility_to2.48140237
13MP0003195_calcinosis2.42346156
14MP0003724_increased_susceptibility_to2.39878933
15MP0005083_abnormal_biliary_tract2.34327259
16MP0003252_abnormal_bile_duct2.12524627
17MP0002138_abnormal_hepatobiliary_system2.11053980
18MP0002419_abnormal_innate_immunity2.10039221
19MP0010329_abnormal_lipoprotein_level2.05731576
20MP0005025_abnormal_response_to2.00085508
21MP0006082_CNS_inflammation1.99294617
22MP0000685_abnormal_immune_system1.96436972
23MP0002148_abnormal_hypersensitivity_rea1.95193941
24MP0003186_abnormal_redox_activity1.90217827
25MP0005464_abnormal_platelet_physiology1.90041859
26MP0005000_abnormal_immune_tolerance1.79223875
27MP0005332_abnormal_amino_acid1.77455363
28MP0008469_abnormal_protein_level1.70228694
29MP0000609_abnormal_liver_physiology1.68735416
30MP0003303_peritoneal_inflammation1.66727231
31MP0001790_abnormal_immune_system1.64951192
32MP0005387_immune_system_phenotype1.64951192
33MP0005319_abnormal_enzyme/_coenzyme1.59266626
34MP0009764_decreased_sensitivity_to1.54604159
35MP0001853_heart_inflammation1.50811037
36MP0005451_abnormal_body_composition1.49922911
37MP0002452_abnormal_antigen_presenting1.49052802
38MP0004510_myositis1.48359411
39MP0002723_abnormal_immune_serum1.48264222
40MP0001800_abnormal_humoral_immune1.47688751
41MP0001666_abnormal_nutrient_absorption1.46790299
42MP0001845_abnormal_inflammatory_respons1.45714458
43MP0001533_abnormal_skeleton_physiology1.43494464
44MP0008004_abnormal_stomach_pH1.43140380
45MP0003656_abnormal_erythrocyte_physiolo1.42279670
46MP0005671_abnormal_response_to1.41037634
47MP0003172_abnormal_lysosome_physiology1.39068887
48MP0002118_abnormal_lipid_homeostasis1.38543567
49MP0001764_abnormal_homeostasis1.36238316
50MP0004019_abnormal_vitamin_homeostasis1.34528838
51MP0000604_amyloidosis1.33879426
52MP0003453_abnormal_keratinocyte_physiol1.32656583
53MP0000343_altered_response_to1.32406393
54MP0009643_abnormal_urine_homeostasis1.31079069
55MP0005584_abnormal_enzyme/coenzyme_acti1.30714515
56MP0009763_increased_sensitivity_to1.30570220
57MP0004947_skin_inflammation1.25363883
58MP0001819_abnormal_immune_cell1.24222445
59MP0002420_abnormal_adaptive_immunity1.23093544
60MP0006054_spinal_hemorrhage1.22036686
61MP0008260_abnormal_autophagy1.19016499
62MP0000598_abnormal_liver_morphology1.15666995
63MP0010155_abnormal_intestine_physiology1.15221644
64MP0003075_altered_response_to1.14962304
65MP0002332_abnormal_exercise_endurance1.10874684
66MP0002405_respiratory_system_inflammati1.08930372
67MP0009333_abnormal_splenocyte_physiolog1.08516392
68MP0005397_hematopoietic_system_phenotyp1.07875293
69MP0001545_abnormal_hematopoietic_system1.07875293
70MP0003763_abnormal_thymus_physiology1.04467094
71MP0003300_gastrointestinal_ulcer1.03078784
72MP0005164_abnormal_response_to1.02475109
73MP0002254_reproductive_system_inflammat1.00646595
74MP0009278_abnormal_bone_marrow1.00081050
75MP0002277_abnormal_respiratory_mucosa0.99009930
76MP0000689_abnormal_spleen_morphology0.96984397
77MP0000716_abnormal_immune_system0.95858032
78MP0003011_delayed_dark_adaptation0.95603043
79MP0005390_skeleton_phenotype0.95374169
80MP0005084_abnormal_gallbladder_morpholo0.95352708
81MP0003828_pulmonary_edema0.95070223
82MP0003868_abnormal_feces_composition0.92931099
83MP0006036_abnormal_mitochondrial_physio0.92708018
84MP0010368_abnormal_lymphatic_system0.91961282
85MP0005636_abnormal_mineral_homeostasis0.89405274
86MP0005310_abnormal_salivary_gland0.88985999
87MP0001663_abnormal_digestive_system0.88027160
88MP0005167_abnormal_blood-brain_barrier0.87866742
89MP0009642_abnormal_blood_homeostasis0.85522910
90MP0000465_gastrointestinal_hemorrhage0.85224258
91MP0003183_abnormal_peptide_metabolism0.85003824
92MP0004782_abnormal_surfactant_physiolog0.84701775
93MP0004883_abnormal_blood_vessel0.84671978
94MP0002398_abnormal_bone_marrow0.83452614
95MP0000920_abnormal_myelination0.83334744
96MP0002429_abnormal_blood_cell0.82842551
97MP0003646_muscle_fatigue0.82744360
98MP0005408_hypopigmentation0.82026083
99MP0001873_stomach_inflammation0.80319430
100MP0002998_abnormal_bone_remodeling0.80093530
101MP0002136_abnormal_kidney_physiology0.79739411
102MP0005166_decreased_susceptibility_to0.79192194
103MP0000249_abnormal_blood_vessel0.76496132
104MP0000858_altered_metastatic_potential0.76329416
105MP0002722_abnormal_immune_system0.75922068
106MP0009765_abnormal_xenobiotic_induced0.74975746
107MP0003329_amyloid_beta_deposits0.74918421
108MP0002928_abnormal_bile_duct0.74304585
109MP0001542_abnormal_bone_strength0.74128070
110MP0002166_altered_tumor_susceptibility0.73971712
111MP0005165_increased_susceptibility_to0.73528482
112MP0001851_eye_inflammation0.72023328
113MP0003448_altered_tumor_morphology0.71811958
114MP0003795_abnormal_bone_structure0.71624574
115MP0008873_increased_physiological_sensi0.70973420
116MP0005220_abnormal_exocrine_pancreas0.70608549
117MP0002877_abnormal_melanocyte_morpholog0.69256381
118MP0008874_decreased_physiological_sensi0.68895837
119MP0003866_abnormal_defecation0.68021696
120MP0002933_joint_inflammation0.67850727
121MP0003690_abnormal_glial_cell0.67165121
122MP0003091_abnormal_cell_migration0.66316516
123MP0009697_abnormal_copulation0.66284976
124MP0005023_abnormal_wound_healing0.61772619
125MP0002132_abnormal_respiratory_system0.60346152
126MP0005076_abnormal_cell_differentiation0.55057926
127MP0000703_abnormal_thymus_morphology0.54079057
128MP0000490_abnormal_crypts_of0.53164249
129MP0005535_abnormal_body_temperature0.52095825
130MP0005647_abnormal_sex_gland0.52012040

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)6.19966367
2Abnormality of liposaccharide metabolism (HP:0010968)6.19966367
3Abnormality of aromatic amino acid family metabolism (HP:0004338)5.08856150
4Retrobulbar optic neuritis (HP:0100654)4.92662298
5Optic neuritis (HP:0100653)4.92662298
6Stomatitis (HP:0010280)4.57886418
7Systemic lupus erythematosus (HP:0002725)4.56925712
8Deep venous thrombosis (HP:0002625)4.43580291
9Recurrent gram-negative bacterial infections (HP:0005420)4.35044600
10Intrahepatic cholestasis (HP:0001406)4.26338968
11Complement deficiency (HP:0004431)4.20361002
12Xanthomatosis (HP:0000991)4.19213103
13Prolonged partial thromboplastin time (HP:0003645)4.06809437
14Joint hemorrhage (HP:0005261)3.95736689
15Vacuolated lymphocytes (HP:0001922)3.91131235
16Abnormality of monocarboxylic acid metabolism (HP:0010996)3.90514980
17Recurrent abscess formation (HP:0002722)3.85767068
18Disinhibition (HP:0000734)3.79790848
19Recurrent bacterial skin infections (HP:0005406)3.77656251
20Abnormality of the common coagulation pathway (HP:0010990)3.53300721
21Abnormality of complement system (HP:0005339)3.50755692
22Eczematoid dermatitis (HP:0000976)3.44534267
23Glomerulonephritis (HP:0000099)3.43907999
24Hyperlipoproteinemia (HP:0010980)3.43590336
25Keratoconjunctivitis sicca (HP:0001097)3.36490182
26Mutism (HP:0002300)3.24533064
27Hypobetalipoproteinemia (HP:0003563)3.22070215
28Abnormality of macrophages (HP:0004311)3.17086899
29Elevated erythrocyte sedimentation rate (HP:0003565)3.11220707
30Keratoconjunctivitis (HP:0001096)3.06641316
31Chronic obstructive pulmonary disease (HP:0006510)3.03601444
32Obstructive lung disease (HP:0006536)3.03601444
33Pulmonary infiltrates (HP:0002113)2.94879150
34Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.93086743
35Myositis (HP:0100614)2.92355591
36Abnormality of the intrinsic pathway (HP:0010989)2.91727789
37Abnormality of fatty-acid metabolism (HP:0004359)2.91581731
38Hypoglycemic coma (HP:0001325)2.90810532
39Hyperammonemia (HP:0001987)2.88637559
40Vasculitis (HP:0002633)2.87840091
41Abnormality of glutamine family amino acid metabolism (HP:0010902)2.82148122
42Increased IgM level (HP:0003496)2.81173090
43Nuclear cataract (HP:0100018)2.79407800
44Recurrent fungal infections (HP:0002841)2.77828847
45Dysostosis multiplex (HP:0000943)2.76124513
46Ketosis (HP:0001946)2.75418956
47Generalized aminoaciduria (HP:0002909)2.73756214
48Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.70605365
49Hemoptysis (HP:0002105)2.68531986
50Mucopolysacchariduria (HP:0008155)2.68123460
51Urinary glycosaminoglycan excretion (HP:0003541)2.68123460
52Hypercholesterolemia (HP:0003124)2.65071082
53Gastrointestinal infarctions (HP:0005244)2.64595493
54Meningitis (HP:0001287)2.64310659
55Fat malabsorption (HP:0002630)2.63300167
56Myocardial infarction (HP:0001658)2.63032117
57Gangrene (HP:0100758)2.62860278
58Gingival bleeding (HP:0000225)2.61547897
59Neurofibrillary tangles (HP:0002185)2.60835207
60Increased cerebral lipofuscin (HP:0011813)2.60467897
61Recurrent skin infections (HP:0001581)2.59566975
62Axonal loss (HP:0003447)2.58299987
63Encephalitis (HP:0002383)2.57162116
64Hypolipoproteinemia (HP:0010981)2.53257387
65Autoimmune thrombocytopenia (HP:0001973)2.52855659
66Increased IgE level (HP:0003212)2.52197922
67Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.52158986
68Abnormality of mucopolysaccharide metabolism (HP:0011020)2.49729465
69Abnormality of polysaccharide metabolism (HP:0011012)2.49729465
70Abnormality of glycosaminoglycan metabolism (HP:0004371)2.49729465
71Abnormality of sulfur amino acid metabolism (HP:0004339)2.48267485
72Increased neuronal autofluorescent lipopigment (HP:0002074)2.45136842
73Progressive neurologic deterioration (HP:0002344)2.43472856
74Orchitis (HP:0100796)2.42963408
75Amyloidosis (HP:0011034)2.42911371
76Hepatosplenomegaly (HP:0001433)2.42377850
77Abnormality of aspartate family amino acid metabolism (HP:0010899)2.42124501
78Abnormality of pyrimidine metabolism (HP:0004353)2.41492590
79Abnormality of methionine metabolism (HP:0010901)2.41069027
80Hematochezia (HP:0002573)2.40221926
81Anorexia (HP:0002039)2.37342154
82Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.36722910
83T lymphocytopenia (HP:0005403)2.35527550
84Hypoalphalipoproteinemia (HP:0003233)2.34026735
85Arterial thrombosis (HP:0004420)2.33991369
86Epistaxis (HP:0000421)2.33467640
87Epidermoid cyst (HP:0200040)2.33226431
88Menorrhagia (HP:0000132)2.32549063
89Hyperbilirubinemia (HP:0002904)2.32184471
90Polyneuropathy (HP:0001271)2.31497432
91Episodic fever (HP:0001954)2.31406547
92Abnormality of nucleobase metabolism (HP:0010932)2.30789004
93Increased serum ferritin (HP:0003281)2.29480159
94Abnormality of iron homeostasis (HP:0011031)2.28848331
95Nephritis (HP:0000123)2.27895637
96Recurrent viral infections (HP:0004429)2.27879300
97Steatorrhea (HP:0002570)2.25659576
98Abnormality of purine metabolism (HP:0004352)2.25437211
99Neuronal loss in central nervous system (HP:0002529)2.22081328
100Esophageal varix (HP:0002040)2.21807409
101Apathy (HP:0000741)2.21730797
102Diminished motivation (HP:0000745)2.21711779
103Abnormality of T cell number (HP:0011839)2.20282652
104Pancreatitis (HP:0001733)2.18793867
105Nausea (HP:0002018)2.17131101
106Abnormal platelet function (HP:0011869)2.16167883
107Impaired platelet aggregation (HP:0003540)2.16167883
108Abnormality of the vasculature of the conjunctiva (HP:0008054)2.16057769
109Abnormality of transition element cation homeostasis (HP:0011030)2.15451730
110Thrombophlebitis (HP:0004418)2.15055131
111Spontaneous hematomas (HP:0007420)2.14756496
112Hyperglycinuria (HP:0003108)2.14331844
113Late onset (HP:0003584)2.13750402
114Hypergammaglobulinemia (HP:0010702)2.13441434
115Upper motor neuron abnormality (HP:0002127)2.13283553
116Urticaria (HP:0001025)2.12588088
117Ketoacidosis (HP:0001993)2.10872231
118Dicarboxylic aciduria (HP:0003215)2.10870174
119Abnormality of dicarboxylic acid metabolism (HP:0010995)2.10870174
120Agnosia (HP:0010524)2.09847976
121Leukocytosis (HP:0001974)2.08631640
122Mediastinal lymphadenopathy (HP:0100721)2.07325550
123Conjugated hyperbilirubinemia (HP:0002908)2.04619846
124Abnormality of the pleura (HP:0002103)2.04222514
125Reduced antithrombin III activity (HP:0001976)2.02666985
126Loss of speech (HP:0002371)2.01095466
127Purpura (HP:0000979)2.00656386
128Interstitial pulmonary disease (HP:0006530)2.00366735
129Acne (HP:0001061)2.00322051
130Inappropriate behavior (HP:0000719)1.99636678
131Delayed CNS myelination (HP:0002188)1.99448590
132Periodontitis (HP:0000704)1.98421338
133Pustule (HP:0200039)1.96952908
134Abnormality of the pericardium (HP:0001697)1.96848551
135Prolonged neonatal jaundice (HP:0006579)1.96690069
136Pulmonary embolism (HP:0002204)1.94770850
137Abnormality of serine family amino acid metabolism (HP:0010894)1.94481939
138Abnormality of glycine metabolism (HP:0010895)1.94481939
139Thrombocytosis (HP:0001894)1.94221790
140Vertigo (HP:0002321)1.93641407
141Metabolic acidosis (HP:0001942)1.93593436
142Hyperglycinemia (HP:0002154)1.92446531
143Glomerulopathy (HP:0100820)1.91794127
144Gingivitis (HP:0000230)1.91726152
145Tetraparesis (HP:0002273)1.90621749
146Joint swelling (HP:0001386)1.90398818
147Malnutrition (HP:0004395)1.90074209
148Spontaneous abortion (HP:0005268)1.89554867
149Pathologic fracture (HP:0002756)1.89041950
150Recurrent cutaneous fungal infections (HP:0011370)1.88090066
151Chronic mucocutaneous candidiasis (HP:0002728)1.88090066
152Petechiae (HP:0000967)1.87971444
153Arthralgia (HP:0002829)1.87803783
154Abnormal delayed hypersensitivity skin test (HP:0002963)1.87445122
155Basal ganglia calcification (HP:0002135)1.87327304
156Thoracic kyphosis (HP:0002942)1.87274520
157Personality changes (HP:0000751)1.86874017
158Mitral stenosis (HP:0001718)1.86497765
159Abnormality of glycosphingolipid metabolism (HP:0004343)1.86274008
160Chest pain (HP:0100749)1.86180576
161Cerebral inclusion bodies (HP:0100314)1.85670125

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.23737061
2TBK13.28866310
3BCKDK3.07395310
4TAOK32.81774927
5TYK22.71965447
6KIT2.65191887
7IRAK32.53736457
8TAOK22.52609765
9MAP3K142.49122364
10BLK2.40324193
11TAOK12.24208739
12TGFBR22.22866160
13NME22.22685141
14IRAK42.16747787
15FLT32.13745568
16IKBKE2.10873758
17PRPF4B2.06164384
18MAP4K11.98181907
19DDR21.92834691
20FGR1.91132787
21IKBKB1.84853186
22FGFR41.83526922
23JAK31.76204709
24MAP2K31.72392580
25ABL21.63096216
26KDR1.61058941
27MAP3K131.60167719
28PIM21.51384522
29ZAP701.48641781
30TRIB31.47658296
31PKN21.43681020
32MOS1.42956394
33EPHB11.42374372
34BTK1.35749956
35TEC1.34192347
36NEK91.33898758
37CSF1R1.32138329
38TESK21.31783689
39MST1R1.31606433
40MAP3K61.29104872
41SIK31.28955431
42ERBB41.28076445
43TNK21.26334917
44CDC42BPA1.24368906
45MAP3K111.24082107
46PBK1.22899139
47JAK11.21614945
48JAK21.20152175
49RPS6KA41.14374985
50IRAK21.10392311
51ARAF1.09195044
52MUSK1.09100378
53RIPK41.07875989
54MAP3K31.06242066
55STK101.00887262
56MATK1.00764783
57CSK0.99934259
58PIK3CG0.99855293
59TGFBR10.99107273
60CHUK0.96485143
61SYK0.94394639
62MAP3K10.93982892
63ADRBK20.93174630
64ACVR1B0.90768596
65MAPK110.90637237
66MARK30.87260966
67TIE10.86868943
68KSR20.85596038
69TXK0.83852395
70LYN0.83521056
71MAP2K20.82211650
72PIM10.80642212
73SIK10.80536770
74NLK0.77968619
75LRRK20.72322673
76PTK60.70638513
77INSRR0.70455117
78TESK10.70369372
79HCK0.69613694
80MAPKAPK30.69419565
81EPHA30.68995121
82LCK0.67371792
83BMPR20.67005191
84GRK70.66783126
85MAP3K50.64411504
86MAP2K60.59508417
87EEF2K0.56877509
88MAP3K20.55763132
89STK160.55072173
90TYRO30.54935820
91PRKG20.54628051
92PDPK10.54555799
93PDK10.53065128
94MAPK40.51835395
95RAF10.49904456
96FES0.49059373
97SIK20.48806747
98ABL10.47929212
99SCYL20.47204009
100IRAK10.46817166
101CAMKK20.46268173
102PRKD20.46003493
103PRKCD0.45485615
104RPS6KC10.44312905
105RPS6KL10.44312905
106EIF2AK30.42569753
107DAPK20.41804045
108BMX0.40770289
109MARK20.40306470
110HIPK20.39333182
111RIPK10.37326095
112MAPKAPK20.37231254
113PINK10.37086210
114GRK60.36696376
115PRKAA20.36352327
116MAPK150.36337135
117CAMK1D0.35968959
118TRPM70.35828248
119RPS6KA60.35756562
120EGFR0.34131174
121DYRK1B0.34127375
122CDK60.34101269
123CLK10.33783983
124FYN0.32629663
125MAPK70.32590584
126STK40.32508352
127ITK0.31687810
128DYRK30.31504310
129MAP3K80.30308558
130RET0.29562882
131PAK40.29220297
132SMG10.26148841
133RPS6KA20.23067950
134MAPK120.19752388

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.55568869
2Staphylococcus aureus infection_Homo sapiens_hsa051503.40836138
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.00001525
4Complement and coagulation cascades_Homo sapiens_hsa046102.85101569
5Pentose and glucuronate interconversions_Homo sapiens_hsa000402.40239955
6Graft-versus-host disease_Homo sapiens_hsa053322.39195187
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.23671334
8Autoimmune thyroid disease_Homo sapiens_hsa053202.15381585
9Arginine biosynthesis_Homo sapiens_hsa002202.15112661
10Fatty acid degradation_Homo sapiens_hsa000712.11074504
11Tryptophan metabolism_Homo sapiens_hsa003802.08874063
12Peroxisome_Homo sapiens_hsa041462.05113478
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.95302295
14Caffeine metabolism_Homo sapiens_hsa002321.94894813
15Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.88732933
16Type I diabetes mellitus_Homo sapiens_hsa049401.80638707
17Folate biosynthesis_Homo sapiens_hsa007901.76035105
18African trypanosomiasis_Homo sapiens_hsa051431.70594308
19Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.70487372
20Histidine metabolism_Homo sapiens_hsa003401.69823212
21Nitrogen metabolism_Homo sapiens_hsa009101.68560593
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.65996907
23Leishmaniasis_Homo sapiens_hsa051401.60425785
24Other glycan degradation_Homo sapiens_hsa005111.60293175
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.59892485
26Salmonella infection_Homo sapiens_hsa051321.58083847
27Maturity onset diabetes of the young_Homo sapiens_hsa049501.49288116
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.49056338
29Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.48182795
30beta-Alanine metabolism_Homo sapiens_hsa004101.46459109
31Selenocompound metabolism_Homo sapiens_hsa004501.40967143
32Chemical carcinogenesis_Homo sapiens_hsa052041.40905932
33PPAR signaling pathway_Homo sapiens_hsa033201.40387623
34Chemokine signaling pathway_Homo sapiens_hsa040621.33242398
35Lysosome_Homo sapiens_hsa041421.30856325
36Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.30646644
37Propanoate metabolism_Homo sapiens_hsa006401.30337432
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.28634189
39Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.28477874
40Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.25764775
41Viral myocarditis_Homo sapiens_hsa054161.24870506
42Fatty acid metabolism_Homo sapiens_hsa012121.24563550
43Pertussis_Homo sapiens_hsa051331.24032266
44Primary immunodeficiency_Homo sapiens_hsa053401.23361236
45Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.23114243
46Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.23021666
47Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.20864457
48Butanoate metabolism_Homo sapiens_hsa006501.19771649
49Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.19735037
50Hepatitis C_Homo sapiens_hsa051601.18215192
51Starch and sucrose metabolism_Homo sapiens_hsa005001.16709760
52Steroid hormone biosynthesis_Homo sapiens_hsa001401.16413357
53Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16207674
54Legionellosis_Homo sapiens_hsa051341.15673096
55Retinol metabolism_Homo sapiens_hsa008301.14336574
56Acute myeloid leukemia_Homo sapiens_hsa052211.14238529
57Sulfur metabolism_Homo sapiens_hsa009201.13259087
58Sulfur relay system_Homo sapiens_hsa041221.11975030
59Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.09974653
60Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.08952003
61ABC transporters_Homo sapiens_hsa020101.04633031
62Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03559980
63T cell receptor signaling pathway_Homo sapiens_hsa046601.02362463
64RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.02135524
65Hepatitis B_Homo sapiens_hsa051611.01346978
66Malaria_Homo sapiens_hsa051441.00389535
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.98620826
68Phenylalanine metabolism_Homo sapiens_hsa003600.97358348
69Fatty acid elongation_Homo sapiens_hsa000620.96044848
70Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.92215084
712-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.91489306
72NF-kappa B signaling pathway_Homo sapiens_hsa040640.91252220
73Osteoclast differentiation_Homo sapiens_hsa043800.88842344
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.87986407
75Pentose phosphate pathway_Homo sapiens_hsa000300.86705809
76Collecting duct acid secretion_Homo sapiens_hsa049660.83520102
77Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.83161938
78Bladder cancer_Homo sapiens_hsa052190.81359955
79Amoebiasis_Homo sapiens_hsa051460.80836722
80Steroid biosynthesis_Homo sapiens_hsa001000.79534894
81Arginine and proline metabolism_Homo sapiens_hsa003300.79384217
82Vitamin digestion and absorption_Homo sapiens_hsa049770.78729768
83Tyrosine metabolism_Homo sapiens_hsa003500.78276805
84Carbon metabolism_Homo sapiens_hsa012000.77659768
85Glutathione metabolism_Homo sapiens_hsa004800.73388062
86Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.73355370
87Pyruvate metabolism_Homo sapiens_hsa006200.72985979
88AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.72913524
89Biosynthesis of amino acids_Homo sapiens_hsa012300.72842749
90Fat digestion and absorption_Homo sapiens_hsa049750.72643687
91Tuberculosis_Homo sapiens_hsa051520.72312093
92Epstein-Barr virus infection_Homo sapiens_hsa051690.71188685
93Bile secretion_Homo sapiens_hsa049760.70149942
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.67956846
95VEGF signaling pathway_Homo sapiens_hsa043700.67899583
96Protein export_Homo sapiens_hsa030600.67384885
97Prolactin signaling pathway_Homo sapiens_hsa049170.66534681
98Galactose metabolism_Homo sapiens_hsa000520.66005166
99Rheumatoid arthritis_Homo sapiens_hsa053230.64581921
100Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.63578987
101Measles_Homo sapiens_hsa051620.61663189
102TNF signaling pathway_Homo sapiens_hsa046680.60410222
103Prion diseases_Homo sapiens_hsa050200.59251556
104Sphingolipid signaling pathway_Homo sapiens_hsa040710.58494322
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58466763
106Sphingolipid metabolism_Homo sapiens_hsa006000.57384709
107Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.57241115
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.56848341
109Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55873413
110Influenza A_Homo sapiens_hsa051640.55602963
111Leukocyte transendothelial migration_Homo sapiens_hsa046700.54803860
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53658584
113Phagosome_Homo sapiens_hsa041450.51257518
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51249997
115Intestinal immune network for IgA production_Homo sapiens_hsa046720.50710200
116B cell receptor signaling pathway_Homo sapiens_hsa046620.47427481
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.47123620
118Neurotrophin signaling pathway_Homo sapiens_hsa047220.46812721
119Toxoplasmosis_Homo sapiens_hsa051450.46201150
120Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45783523
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.45369489
122Glycerolipid metabolism_Homo sapiens_hsa005610.45195666
123Vibrio cholerae infection_Homo sapiens_hsa051100.44972573
124Cyanoamino acid metabolism_Homo sapiens_hsa004600.44795106
125Herpes simplex infection_Homo sapiens_hsa051680.44447499
126Antigen processing and presentation_Homo sapiens_hsa046120.44337150
127One carbon pool by folate_Homo sapiens_hsa006700.44143178
128Endocytosis_Homo sapiens_hsa041440.43943505
129Pancreatic cancer_Homo sapiens_hsa052120.43129702
130Chronic myeloid leukemia_Homo sapiens_hsa052200.43026781
131Shigellosis_Homo sapiens_hsa051310.42361917
132Allograft rejection_Homo sapiens_hsa053300.42359555
133Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41540807
134Apoptosis_Homo sapiens_hsa042100.41189520
135Asthma_Homo sapiens_hsa053100.41075486
136HTLV-I infection_Homo sapiens_hsa051660.40667284
137Hematopoietic cell lineage_Homo sapiens_hsa046400.37838200
138Mineral absorption_Homo sapiens_hsa049780.36779618
139HIF-1 signaling pathway_Homo sapiens_hsa040660.36258710
140Platelet activation_Homo sapiens_hsa046110.35568444
141Notch signaling pathway_Homo sapiens_hsa043300.35508348
142Type II diabetes mellitus_Homo sapiens_hsa049300.33890814
143Viral carcinogenesis_Homo sapiens_hsa052030.31251832
144Insulin resistance_Homo sapiens_hsa049310.31141115
145Transcriptional misregulation in cancer_Homo sapiens_hsa052020.28553730
146Fructose and mannose metabolism_Homo sapiens_hsa000510.26154112
147Renal cell carcinoma_Homo sapiens_hsa052110.25706362
148Non-small cell lung cancer_Homo sapiens_hsa052230.23300570
149Phospholipase D signaling pathway_Homo sapiens_hsa040720.21786437
150FoxO signaling pathway_Homo sapiens_hsa040680.21642320
151MAPK signaling pathway_Homo sapiens_hsa040100.18309480
152Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.15884774
153Systemic lupus erythematosus_Homo sapiens_hsa053220.14654632
154Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.12648478
155mTOR signaling pathway_Homo sapiens_hsa041500.12483520
156GnRH signaling pathway_Homo sapiens_hsa049120.09300664

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