NINJ2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene belongs to the ninjurin (for nerve injury induced) family. It is a cell surface adhesion protein that is upregulated in Schwann cells surrounding the distal segment of injured nerve, and promotes neurite outgrowth, thus may have a role in nerve regeneration after nerve injury. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fatty acid elongation (GO:0030497)7.80461974
2axon ensheathment (GO:0008366)7.54231828
3ensheathment of neurons (GO:0007272)7.54231828
4myelination (GO:0042552)7.50679705
5long-chain fatty acid biosynthetic process (GO:0042759)6.06800786
6myelin maintenance (GO:0043217)5.77039745
7apical protein localization (GO:0045176)5.58294202
8positive regulation of gamma-delta T cell activation (GO:0046645)5.57845442
9negative regulation of neurotransmitter secretion (GO:0046929)5.44740871
10glycerophospholipid catabolic process (GO:0046475)5.40529377
11neutrophil activation involved in immune response (GO:0002283)5.27607456
12oligodendrocyte differentiation (GO:0048709)5.20871182
13asymmetric protein localization (GO:0008105)5.13484413
14antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.84925296
15negative regulation of neurotransmitter transport (GO:0051589)4.75944530
16cholesterol biosynthetic process (GO:0006695)4.73548898
17regulation of B cell receptor signaling pathway (GO:0050855)4.72046273
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.65544709
19establishment of mitochondrion localization (GO:0051654)4.59050415
20eye photoreceptor cell differentiation (GO:0001754)4.58836345
21photoreceptor cell differentiation (GO:0046530)4.58836345
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.58489037
23negative regulation of cell killing (GO:0031342)4.58489037
24creatine metabolic process (GO:0006600)4.56832161
25positive regulation of oligodendrocyte differentiation (GO:0048714)4.56756476
26negative regulation of protein localization to cell surface (GO:2000009)4.55664562
27regulation of collateral sprouting (GO:0048670)4.43933972
28immunoglobulin mediated immune response (GO:0016064)4.30172398
29virion attachment to host cell (GO:0019062)4.24035216
30adhesion of symbiont to host cell (GO:0044650)4.24035216
31positive regulation of B cell differentiation (GO:0045579)4.21169003
32astrocyte development (GO:0014002)4.20741802
33sterol biosynthetic process (GO:0016126)4.12384943
34antigen processing and presentation of endogenous antigen (GO:0019883)4.11983904
35presynaptic membrane organization (GO:0097090)4.11075397
36peptidyl-tyrosine autophosphorylation (GO:0038083)4.01977628
37antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.00846414
38response to redox state (GO:0051775)3.98658157
39neutrophil activation (GO:0042119)3.97868710
40granulocyte activation (GO:0036230)3.93595410
41regulation of gamma-delta T cell activation (GO:0046643)3.90485613
42substantia nigra development (GO:0021762)3.89293086
43modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.88341596
44positive regulation by organism of defense response of other organism involved in symbiotic interact3.88341596
45modulation by symbiont of host immune response (GO:0052553)3.88341596
46positive regulation by symbiont of host defense response (GO:0052509)3.88341596
47modulation by symbiont of host defense response (GO:0052031)3.88341596
48modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.88341596
49presynaptic membrane assembly (GO:0097105)3.88229927
50negative regulation of JUN kinase activity (GO:0043508)3.85799707
51membrane tubulation (GO:0097320)3.85023988
52detection of other organism (GO:0098543)3.83180684
53regulation of regulatory T cell differentiation (GO:0045589)3.82108781
54response to peptidoglycan (GO:0032494)3.79673262
55leukocyte aggregation (GO:0070486)3.76683821
56B cell mediated immunity (GO:0019724)3.71307568
57negative regulation of interleukin-12 production (GO:0032695)3.70845335
58response to interleukin-15 (GO:0070672)3.69550591
59long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.68221425
60detection of bacterium (GO:0016045)3.67916781
61negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.67355811
62cytidine metabolic process (GO:0046087)3.66073300
63cytidine catabolic process (GO:0006216)3.66073300
64cytidine deamination (GO:0009972)3.66073300
65response to lipoprotein particle (GO:0055094)3.64432729
66regulation of gamma-delta T cell differentiation (GO:0045586)3.63662176
67isoprenoid biosynthetic process (GO:0008299)3.63246842
68macrophage activation involved in immune response (GO:0002281)3.61445841
69GPI anchor biosynthetic process (GO:0006506)3.60344080
70positive regulation of mast cell activation (GO:0033005)3.59406572
71regulation of mast cell degranulation (GO:0043304)3.58298959
72amyloid precursor protein metabolic process (GO:0042982)3.55473646
73cellular response to interleukin-15 (GO:0071350)3.53989752
74myeloid cell activation involved in immune response (GO:0002275)3.53129660
75antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.52681221
76import into cell (GO:0098657)3.49285310
77GPI anchor metabolic process (GO:0006505)3.47027224
78regulation of B cell differentiation (GO:0045577)3.45433186
79B cell receptor signaling pathway (GO:0050853)3.44716622
80positive regulation of action potential (GO:0045760)3.43984419
81protein palmitoylation (GO:0018345)3.42041818
82cellular extravasation (GO:0045123)3.39095008
83tolerance induction (GO:0002507)3.38042187
84limb bud formation (GO:0060174)3.37535089
85positive thymic T cell selection (GO:0045059)3.35337258
86leukocyte degranulation (GO:0043299)3.34475558
87long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.33899344
88regulation of T cell tolerance induction (GO:0002664)3.33818965
89respiratory burst (GO:0045730)3.30434939
90myelination in peripheral nervous system (GO:0022011)3.29511321
91peripheral nervous system axon ensheathment (GO:0032292)3.29511321
92positive regulation of mast cell degranulation (GO:0043306)3.28247307
93positive regulation of mast cell activation involved in immune response (GO:0033008)3.28247307
94microtubule polymerization or depolymerization (GO:0031109)3.27133717
95adult walking behavior (GO:0007628)3.26975180
96regulation of alpha-beta T cell proliferation (GO:0046640)3.25086257
97response to methylmercury (GO:0051597)3.23699651
98regulation of mast cell activation involved in immune response (GO:0033006)3.23546100
99detection of external biotic stimulus (GO:0098581)3.23191474
100ear development (GO:0043583)3.22434657
101negative T cell selection (GO:0043383)3.21710966
102positive regulation of glial cell differentiation (GO:0045687)3.21300643
103regulation of tolerance induction (GO:0002643)3.21011426
104Arp2/3 complex-mediated actin nucleation (GO:0034314)3.19658229
105fatty-acyl-CoA biosynthetic process (GO:0046949)3.19433054
106axon development (GO:0061564)3.17007853
107negative thymic T cell selection (GO:0045060)3.16917138
108leukocyte migration involved in inflammatory response (GO:0002523)3.16559387
109negative regulation of execution phase of apoptosis (GO:1900118)3.16307943
110negative regulation of lymphocyte mediated immunity (GO:0002707)3.16270870
111pyrimidine ribonucleoside catabolic process (GO:0046133)3.15940029
112adhesion of symbiont to host (GO:0044406)3.13499191
113regulation of myeloid leukocyte mediated immunity (GO:0002886)3.13347830
114glycosylceramide metabolic process (GO:0006677)3.13319660
115regulation of interferon-beta biosynthetic process (GO:0045357)3.11005290
116L-amino acid import (GO:0043092)3.09733729
117positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.08506552
118negative regulation of leukocyte mediated immunity (GO:0002704)3.07079807
119nucleotide transmembrane transport (GO:1901679)3.06206632
120regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.06153563
121regulation of mast cell activation (GO:0033003)3.06018900
122positive regulation of cellular amine metabolic process (GO:0033240)3.04626128
123negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)3.04336710
124negative regulation of axonogenesis (GO:0050771)3.02824689
125negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.02313232
126mast cell activation (GO:0045576)3.02071994
127positive regulation of tolerance induction (GO:0002645)3.01127537
128preassembly of GPI anchor in ER membrane (GO:0016254)3.00917505
129transmission of nerve impulse (GO:0019226)3.00274854
130detection of molecule of bacterial origin (GO:0032490)2.99984240
131negative regulation of T cell mediated immunity (GO:0002710)2.99876245
132peptidyl-cysteine modification (GO:0018198)2.98906788
133nerve growth factor signaling pathway (GO:0038180)2.98780182
134glial cell development (GO:0021782)2.98656471
135response to host immune response (GO:0052572)2.98182495
136response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.98182495
137defense response to protozoan (GO:0042832)2.98105664
138cerebral cortex radially oriented cell migration (GO:0021799)2.97209880
139organ growth (GO:0035265)2.97155067
140interferon-gamma-mediated signaling pathway (GO:0060333)2.96179206
141negative regulation of acute inflammatory response (GO:0002674)2.95932718
142T cell migration (GO:0072678)2.95480223
143magnesium ion transport (GO:0015693)2.95186583
144regulation of leukocyte degranulation (GO:0043300)2.94225494
145fatty-acyl-CoA metabolic process (GO:0035337)2.93442951
146microglial cell activation (GO:0001774)2.93142314
147regulation of lipoprotein metabolic process (GO:0050746)2.92733823
148Leydig cell differentiation (GO:0033327)2.90707808
149type I interferon signaling pathway (GO:0060337)2.89828632
150cellular response to type I interferon (GO:0071357)2.89828632
151amyloid precursor protein catabolic process (GO:0042987)2.89772437
152positive regulation of alpha-beta T cell proliferation (GO:0046641)2.88821349
153positive regulation of gliogenesis (GO:0014015)2.88432390
154lipopolysaccharide-mediated signaling pathway (GO:0031663)2.88082393
155negative regulation of T cell apoptotic process (GO:0070233)2.87788700
156regulation of somitogenesis (GO:0014807)2.87407691
157neutrophil mediated immunity (GO:0002446)2.87255325
158response to type I interferon (GO:0034340)2.86629218
159positive T cell selection (GO:0043368)2.86492465
160T cell selection (GO:0045058)2.86001979
161mature B cell differentiation involved in immune response (GO:0002313)2.84886221
162detection of biotic stimulus (GO:0009595)2.84195917
163peripheral nervous system development (GO:0007422)2.82864135
164negative regulation of cytokine production involved in immune response (GO:0002719)2.82180656
165chaperone-mediated protein transport (GO:0072321)2.81949973
166negative regulation of macroautophagy (GO:0016242)2.81287214
167macrophage activation (GO:0042116)2.80918036
168regulation of natural killer cell mediated immunity (GO:0002715)2.80804086
169regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.80804086
170positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.80151670
171membrane raft organization (GO:0031579)2.79166772
172regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.78953175
173positive regulation of granulocyte differentiation (GO:0030854)2.78834677
174antigen receptor-mediated signaling pathway (GO:0050851)2.78756663
175DNA deamination (GO:0045006)2.77885392
176regulation of antigen processing and presentation (GO:0002577)2.77847329
177regulation of interleukin-2 biosynthetic process (GO:0045076)2.77825168
178protein neddylation (GO:0045116)2.77165072
179cellular response to epinephrine stimulus (GO:0071872)2.76594793
180regulation of T-helper 2 cell differentiation (GO:0045628)2.74192502
181histone H2B ubiquitination (GO:0033523)2.73955267
182response to interferon-beta (GO:0035456)2.73279463
183interleukin-6-mediated signaling pathway (GO:0070102)2.72677842
184very long-chain fatty acid metabolic process (GO:0000038)2.67734900
185dopamine biosynthetic process (GO:0042416)2.66060720
186positive regulation of actin filament depolymerization (GO:0030836)2.65515232
187protein polyglutamylation (GO:0018095)2.65262751
188mannosylation (GO:0097502)2.63707094
189glial cell differentiation (GO:0010001)2.61584553
190regulation of dopamine metabolic process (GO:0042053)2.61286436
191regulation of catecholamine metabolic process (GO:0042069)2.61286436
192positive regulation of cell fate commitment (GO:0010455)2.57501142
193negative regulation of inclusion body assembly (GO:0090084)2.57477705
194positive regulation of interleukin-17 production (GO:0032740)2.56415629
195neural nucleus development (GO:0048857)2.49898034
196response to lead ion (GO:0010288)2.49285797
197lateral sprouting from an epithelium (GO:0060601)2.48651791
198axon ensheathment in central nervous system (GO:0032291)12.2994295
199central nervous system myelination (GO:0022010)12.2994295

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.81656715
2IRF8_22096565_ChIP-ChIP_GC-B_Human5.33630911
3IRF8_21731497_ChIP-ChIP_J774_Mouse3.87054695
4STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.85020669
5GBX2_23144817_ChIP-Seq_PC3_Human3.50833010
6MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.43741619
7* FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.27136994
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.22200083
9IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.03559842
10SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.82696447
11TAF15_26573619_Chip-Seq_HEK293_Human2.76868863
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.74670787
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.73162406
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.70889215
15* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.67357982
16SCL_19346495_ChIP-Seq_HPC-7_Human2.66937412
17IRF8_27001747_Chip-Seq_BMDM_Mouse2.62287690
18MYB_26560356_Chip-Seq_TH2_Human2.59250854
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.55280822
20SPI1_23547873_ChIP-Seq_NB4_Human2.54455628
21MYB_21317192_ChIP-Seq_ERMYB_Mouse2.48651004
22RUNX_20019798_ChIP-Seq_JUKART_Human2.47364982
23VDR_21846776_ChIP-Seq_THP-1_Human2.37939295
24NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.37409552
25SPI1_23127762_ChIP-Seq_K562_Human2.31729904
26E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.30708569
27* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.30596237
28VDR_24763502_ChIP-Seq_THP-1_Human2.30565779
29MAF_26560356_Chip-Seq_TH1_Human2.20752324
30* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.20605911
31UTX_26944678_Chip-Seq_JUKART_Human2.09161003
32ELF1_17652178_ChIP-ChIP_JURKAT_Human2.07812394
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.07676723
34RUNX1_22412390_ChIP-Seq_EML_Mouse2.05374644
35MYB_26560356_Chip-Seq_TH1_Human2.04071952
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.02169183
37E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.01254968
38GATA1_22025678_ChIP-Seq_K562_Human2.01158880
39VDR_22108803_ChIP-Seq_LS180_Human2.00959728
40SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.98159532
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.92881913
42CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.92340700
43JARID2_20064375_ChIP-Seq_MESCs_Mouse1.90882668
44LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.89666424
45ZFP57_27257070_Chip-Seq_ESCs_Mouse1.88824442
46SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.87924933
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.85999351
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.85788682
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85119047
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.84194751
51ER_23166858_ChIP-Seq_MCF-7_Human1.83676753
52MTF2_20144788_ChIP-Seq_MESCs_Mouse1.82679731
53PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.81190017
54AR_21572438_ChIP-Seq_LNCaP_Human1.78181687
55RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.77573141
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.77006572
57MAF_26560356_Chip-Seq_TH2_Human1.75330890
58EZH2_27304074_Chip-Seq_ESCs_Mouse1.75132109
59POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73155811
60SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.71344692
61* GATA3_27048872_Chip-Seq_THYMUS_Human1.70610279
62RNF2_18974828_ChIP-Seq_MESCs_Mouse1.70216343
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.70216343
64MYC_22102868_ChIP-Seq_BL_Human1.68101266
65STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.65552338
66EZH2_27294783_Chip-Seq_ESCs_Mouse1.64150769
67SUZ12_27294783_Chip-Seq_ESCs_Mouse1.63212587
68SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.63003038
69GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.56221073
70GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.55054275
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54967372
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.54362608
73Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.54126125
74EED_16625203_ChIP-ChIP_MESCs_Mouse1.52963184
75GATA1_19941827_ChIP-Seq_MEL_Mouse1.52962805
76EZH2_22144423_ChIP-Seq_EOC_Human1.51002292
77CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.50703139
78* SMAD3_21741376_ChIP-Seq_EPCs_Human1.48002472
79GATA1_19941826_ChIP-Seq_K562_Human1.46956775
80SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.46165753
81RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.46057672
82GATA1_26923725_Chip-Seq_HPCs_Mouse1.44457376
83TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44099450
84GATA2_22383799_ChIP-Seq_G1ME_Mouse1.43934073
85* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.43343714
86SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.41872981
87SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.40156069
88RNF2_27304074_Chip-Seq_ESCs_Mouse1.40093651
89FUS_26573619_Chip-Seq_HEK293_Human1.39769587
90GATA3_26560356_Chip-Seq_TH2_Human1.39643138
91EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.38602195
92CTBP1_25329375_ChIP-Seq_LNCAP_Human1.37657873
93LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37049716
94WT1_19549856_ChIP-ChIP_CCG9911_Human1.36654462
95BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35949352
96CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.31747207
97PIAS1_25552417_ChIP-Seq_VCAP_Human1.31497327
98CBX2_27304074_Chip-Seq_ESCs_Mouse1.31461047
99PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30875377
100GATA1_22383799_ChIP-Seq_G1ME_Mouse1.30461922
101RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.27800674
102VDR_24787735_ChIP-Seq_THP-1_Human1.27061852
103TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.26361015
104TCF7_22412390_ChIP-Seq_EML_Mouse1.25703752
105BCL6_27268052_Chip-Seq_Bcells_Human1.25512157
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.25231379
107SMAD_19615063_ChIP-ChIP_OVARY_Human1.25076904
108TAL1_26923725_Chip-Seq_HPCs_Mouse1.24442144
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.23618033
110JARID2_20075857_ChIP-Seq_MESCs_Mouse1.22881930
111P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22501339
112SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22061989
113PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.21952009
114TRIM28_21343339_ChIP-Seq_HEK293_Human1.21409891
115SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.21282865
116RNF2_27304074_Chip-Seq_NSC_Mouse1.20430974
117CTBP2_25329375_ChIP-Seq_LNCAP_Human1.20221061
118CMYC_18555785_Chip-Seq_ESCs_Mouse1.19625509
119CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.19447644
120ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19376728
121ELK3_25401928_ChIP-Seq_HUVEC_Human1.19158688
122MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.18997624
123NRF2_20460467_ChIP-Seq_MEFs_Mouse1.18812053
124NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.18812053
125* KDM2B_26808549_Chip-Seq_DND41_Human1.18462962
126GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17716880
127NANOG_18555785_Chip-Seq_ESCs_Mouse1.16702081
128CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16497473
129* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15973720
130* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15908507
131PU.1_20513432_ChIP-Seq_Bcells_Mouse1.15835527
132CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.15611761
133PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.14875584
134DROSHA_22980978_ChIP-Seq_HELA_Human1.14802295
135* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.14778356
136STAT3_23295773_ChIP-Seq_U87_Human1.13544509
137BCOR_27268052_Chip-Seq_Bcells_Human1.13264454
138EP300_21415370_ChIP-Seq_HL-1_Mouse1.13227046
139P300_19829295_ChIP-Seq_ESCs_Human1.13051631
140SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12752189
141SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12349612
142KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11908670
143ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.09538581
144GATA2_21666600_ChIP-Seq_HMVEC_Human1.08595596
145RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08588022
146GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.08489906
147SPI1_20517297_ChIP-Seq_HL60_Human1.07861894
148P300_18555785_Chip-Seq_ESCs_Mouse1.07641193
149TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07087949
150HTT_18923047_ChIP-ChIP_STHdh_Human1.07003718
151LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06221324
152ELF1_20517297_ChIP-Seq_JURKAT_Human1.05411986
153TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04863857
154PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04676103
155* EOMES_21245162_ChIP-Seq_HESCs_Human1.04468356
156EGR1_19374776_ChIP-ChIP_THP-1_Human1.03272985
157LXR_22292898_ChIP-Seq_THP-1_Human1.01662675
158GATA2_19941826_ChIP-Seq_K562_Human1.01369473
159* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.00196899
160PU_27001747_Chip-Seq_BMDM_Mouse1.00039126
161PCGF2_27294783_Chip-Seq_ESCs_Mouse0.99814334
162SOX2_19829295_ChIP-Seq_ESCs_Human0.99394399
163NANOG_19829295_ChIP-Seq_ESCs_Human0.99394399
164TCF4_23295773_ChIP-Seq_U87_Human0.98719387
165* PRDM14_20953172_ChIP-Seq_ESCs_Human0.98496221
166EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98142410
167THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97466911
168* TBL1_22424771_ChIP-Seq_293T_Human0.97380147
169SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.96637387
170STAT1_20625510_ChIP-Seq_HELA_Human0.96133019
171TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.95143936
172KDM2B_26808549_Chip-Seq_REH_Human0.94988712
173IRF1_19129219_ChIP-ChIP_H3396_Human0.94796439
174KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.94584776
175EWS_26573619_Chip-Seq_HEK293_Human0.94509969
176HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93961774
177VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.93606565
178KLF4_18555785_Chip-Seq_ESCs_Mouse0.93461871
179UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.93443144
180* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93442006
181EZH2_27294783_Chip-Seq_NPCs_Mouse0.92111394
182STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.91796082
183CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.91598981
184PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91304881
185FLI1_27457419_Chip-Seq_LIVER_Mouse0.90770643
186POU5F1_16153702_ChIP-ChIP_HESCs_Human0.90460632
187NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90313279
188RARB_27405468_Chip-Seq_BRAIN_Mouse0.89952191
189CTCF_27219007_Chip-Seq_ERYTHROID_Human0.89772289
190* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89233638
191* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.86227282
192P300_27268052_Chip-Seq_Bcells_Human0.84161269
193IKZF1_21737484_ChIP-ChIP_HCT116_Human0.83621568
194EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.82673001
195NCOR1_26117541_ChIP-Seq_K562_Human0.82157487
196GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79848643
197CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.79669280

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000920_abnormal_myelination5.95510772
2MP0003950_abnormal_plasma_membrane4.51511627
3MP0003724_increased_susceptibility_to3.92520735
4MP0001835_abnormal_antigen_presentation3.90427429
5MP0003880_abnormal_central_pattern3.71262626
6MP0004270_analgesia3.59612419
7MP0003436_decreased_susceptibility_to3.52570247
8MP0005671_abnormal_response_to3.47217827
9MP0005000_abnormal_immune_tolerance3.05226472
10MP0003690_abnormal_glial_cell3.00628664
11MP0003303_peritoneal_inflammation2.98240206
12MP0001529_abnormal_vocalization2.93106076
13MP0009785_altered_susceptibility_to2.87713877
14MP0002419_abnormal_innate_immunity2.86798575
15MP0005464_abnormal_platelet_physiology2.85812055
16MP0005025_abnormal_response_to2.85540348
17MP0001905_abnormal_dopamine_level2.83841980
18MP0003136_yellow_coat_color2.83267862
19MP0002148_abnormal_hypersensitivity_rea2.82459306
20MP0003329_amyloid_beta_deposits2.82227987
21MP0001800_abnormal_humoral_immune2.80146877
22MP0005387_immune_system_phenotype2.73596696
23MP0001790_abnormal_immune_system2.73596696
24MP0004885_abnormal_endolymph2.65731262
25MP0002723_abnormal_immune_serum2.61860852
26MP0004742_abnormal_vestibular_system2.54513154
27MP0005171_absent_coat_pigmentation2.52783156
28MP0002420_abnormal_adaptive_immunity2.49964427
29MP0005451_abnormal_body_composition2.46581074
30MP0002452_abnormal_antigen_presenting2.46557993
31MP0001819_abnormal_immune_cell2.46190766
32MP0003763_abnormal_thymus_physiology2.44268983
33MP0009333_abnormal_splenocyte_physiolog2.43828667
34MP0000685_abnormal_immune_system2.41303256
35MP0001485_abnormal_pinna_reflex2.40150324
36MP0003806_abnormal_nucleotide_metabolis2.39797274
37MP0003634_abnormal_glial_cell2.26212262
38MP0002272_abnormal_nervous_system2.24631182
39MP0002132_abnormal_respiratory_system2.07586923
40MP0002398_abnormal_bone_marrow2.02183705
41MP0002405_respiratory_system_inflammati2.01881857
42MP0001486_abnormal_startle_reflex2.01344902
43MP0000462_abnormal_digestive_system1.98774286
44MP0010678_abnormal_skin_adnexa1.97618307
45MP0003300_gastrointestinal_ulcer1.96247200
46MP0010155_abnormal_intestine_physiology1.94028256
47MP0005410_abnormal_fertilization1.93851309
48MP0000778_abnormal_nervous_system1.92751867
49MP0000716_abnormal_immune_system1.91892456
50MP0004142_abnormal_muscle_tone1.88198727
51MP0002229_neurodegeneration1.84834575
52MP0003632_abnormal_nervous_system1.83599347
53MP0003191_abnormal_cellular_cholesterol1.82167447
54MP0000383_abnormal_hair_follicle1.81949866
55MP0001533_abnormal_skeleton_physiology1.80771226
56MP0005409_darkened_coat_color1.79641125
57MP0001845_abnormal_inflammatory_respons1.79098944
58MP0000465_gastrointestinal_hemorrhage1.77712106
59MP0004381_abnormal_hair_follicle1.76547161
60MP0003075_altered_response_to1.69710078
61MP0002064_seizures1.69436849
62MP0004859_abnormal_synaptic_plasticity1.68058661
63MP0000689_abnormal_spleen_morphology1.67271007
64MP0002722_abnormal_immune_system1.67071954
65MP0004947_skin_inflammation1.64882896
66MP0001346_abnormal_lacrimal_gland1.64644204
67MP0009764_decreased_sensitivity_to1.60527163
68MP0002429_abnormal_blood_cell1.59914612
69MP0002734_abnormal_mechanical_nocicepti1.53812816
70MP0008260_abnormal_autophagy1.53234437
71MP0008469_abnormal_protein_level1.51365432
72MP0009278_abnormal_bone_marrow1.51310496
73MP0001873_stomach_inflammation1.50763389
74MP0004147_increased_porphyrin_level1.49969792
75MP0003866_abnormal_defecation1.48904232
76MP0004043_abnormal_pH_regulation1.48902216
77MP0001853_heart_inflammation1.48583907
78MP0001545_abnormal_hematopoietic_system1.47060085
79MP0005397_hematopoietic_system_phenotyp1.47060085
80MP0008004_abnormal_stomach_pH1.46555062
81MP0000579_abnormal_nail_morphology1.44288596
82MP0000703_abnormal_thymus_morphology1.44109498
83MP0000604_amyloidosis1.43233751
84MP0009046_muscle_twitch1.40845578
85MP0001851_eye_inflammation1.40138931
86MP0000955_abnormal_spinal_cord1.38926142
87MP0004134_abnormal_chest_morphology1.38659380
88MP0003718_maternal_effect1.36657790
89MP0003172_abnormal_lysosome_physiology1.31633969
90MP0002396_abnormal_hematopoietic_system1.31328840
91MP0002166_altered_tumor_susceptibility1.30726266
92MP0001963_abnormal_hearing_physiology1.30398749
93MP0000343_altered_response_to1.28439903
94MP0003937_abnormal_limbs/digits/tail_de1.27911243
95MP0000566_synostosis1.27149289
96MP0004185_abnormal_adipocyte_glucose1.26254339
97MP0005408_hypopigmentation1.26071634
98MP0004145_abnormal_muscle_electrophysio1.25801820
99MP0001299_abnormal_eye_distance/1.24161806
100MP0003635_abnormal_synaptic_transmissio1.23774077
101MP0003828_pulmonary_edema1.23113096
102MP0002882_abnormal_neuron_morphology1.22412831
103MP0001661_extended_life_span1.20396735
104MP0009745_abnormal_behavioral_response1.20282583
105MP0005310_abnormal_salivary_gland1.20173710
106MP0002277_abnormal_respiratory_mucosa1.19473942
107MP0005551_abnormal_eye_electrophysiolog1.18897067
108MP0000858_altered_metastatic_potential1.18400723
109MP0002998_abnormal_bone_remodeling1.17220244
110MP0003631_nervous_system_phenotype1.16813555
111MP0004510_myositis1.15274563
112MP0003938_abnormal_ear_development1.14745456
113MP0005386_behavior/neurological_phenoty1.14459016
114MP0004924_abnormal_behavior1.14459016
115MP0002752_abnormal_somatic_nervous1.13439324
116MP0005423_abnormal_somatic_nervous1.11446662
117MP0001440_abnormal_grooming_behavior1.10169951
118MP0005166_decreased_susceptibility_to1.10087021
119MP0002066_abnormal_motor_capabilities/c1.09259434
120MP0000747_muscle_weakness1.08526747
121MP0000762_abnormal_tongue_morphology1.07931100
122MP0009763_increased_sensitivity_to1.03984349
123MP0002295_abnormal_pulmonary_circulatio0.99918558
124MP0003448_altered_tumor_morphology0.97719382
125MP0003183_abnormal_peptide_metabolism0.95524839
126MP0002572_abnormal_emotion/affect_behav0.95108770
127MP0001970_abnormal_pain_threshold0.94314072
128MP0005195_abnormal_posterior_eye0.91581541
129MP0001348_abnormal_lacrimal_gland0.89746296
130MP0000647_abnormal_sebaceous_gland0.89707591
131MP0008438_abnormal_cutaneous_collagen0.88375187
132MP0005058_abnormal_lysosome_morphology0.88367795
133MP0002006_tumorigenesis0.87858054
134MP0002067_abnormal_sensory_capabilities0.87513387
135MP0008569_lethality_at_weaning0.87359429
136MP0006036_abnormal_mitochondrial_physio0.86072647
137MP0009765_abnormal_xenobiotic_induced0.85577310
138MP0000026_abnormal_inner_ear0.85476607
139MP0004808_abnormal_hematopoietic_stem0.81445017
140MP0002938_white_spotting0.81002796
141MP0005075_abnormal_melanosome_morpholog0.80474498
142MP0003633_abnormal_nervous_system0.79271385
143MP0004036_abnormal_muscle_relaxation0.78756184
144MP0000490_abnormal_crypts_of0.77489706
145MP0000249_abnormal_blood_vessel0.76544676
146MP0002063_abnormal_learning/memory/cond0.76269010
147MP0002138_abnormal_hepatobiliary_system0.75820241
148MP0001727_abnormal_embryo_implantation0.75692032
149MP0000467_abnormal_esophagus_morphology0.75366725
150MP0001663_abnormal_digestive_system0.75285217
151MP0005083_abnormal_biliary_tract0.74885317
152MP0001340_abnormal_eyelid_morphology0.74830740
153MP0005164_abnormal_response_to0.74517696
154MP0006072_abnormal_retinal_apoptosis0.73963946
155MP0002152_abnormal_brain_morphology0.72713698
156MP0003195_calcinosis0.71190163
157MP0009250_abnormal_appendicular_skeleto0.70326187
158MP0009840_abnormal_foam_cell0.70017246
159MP0004883_abnormal_blood_vessel0.69939257
160MP0005623_abnormal_meninges_morphology0.69840241
161MP0008877_abnormal_DNA_methylation0.69550358
162MP0003045_fibrosis0.69008890
163MP0005390_skeleton_phenotype0.68281254
164MP0008874_decreased_physiological_sensi0.67827815
165MP0005165_increased_susceptibility_to0.67739766
166MP0005319_abnormal_enzyme/_coenzyme0.67304965
167MP0002733_abnormal_thermal_nociception0.66774623
168MP0000639_abnormal_adrenal_gland0.65289302
169MP0002933_joint_inflammation0.64833133
170MP0000631_abnormal_neuroendocrine_gland0.64017604
171MP0006082_CNS_inflammation0.63762337
172MP0002019_abnormal_tumor_incidence0.63361832
173MP0004133_heterotaxia0.62802126
174MP0006054_spinal_hemorrhage0.60957728
175MP0003656_abnormal_erythrocyte_physiolo0.60149537
176MP0001177_atelectasis0.59134049
177MP0003795_abnormal_bone_structure0.59054467
178MP0003137_abnormal_impulse_conducting0.58398282
179MP0001986_abnormal_taste_sensitivity0.57535302
180MP0005253_abnormal_eye_physiology0.57417534
181MP0002332_abnormal_exercise_endurance0.56636149
182MP0008873_increased_physiological_sensi0.55206345
183MP0005584_abnormal_enzyme/coenzyme_acti0.54943988
184MP0005646_abnormal_pituitary_gland0.53937642
185MP0000015_abnormal_ear_pigmentation0.53672233
186MP0000609_abnormal_liver_physiology0.53103465
187MP0005167_abnormal_blood-brain_barrier0.52608205

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)7.00386100
2Degeneration of the lateral corticospinal tracts (HP:0002314)7.00386100
3Neurofibrillary tangles (HP:0002185)6.34083963
4Sensory axonal neuropathy (HP:0003390)6.08463338
5Parakeratosis (HP:0001036)5.22711683
6Elevated erythrocyte sedimentation rate (HP:0003565)5.22588970
7Abnormality of the corticospinal tract (HP:0002492)5.01769528
8Recurrent abscess formation (HP:0002722)4.85021744
9Myositis (HP:0100614)4.84595927
10Stomatitis (HP:0010280)4.80447560
11Recurrent bacterial skin infections (HP:0005406)4.74583647
12Peripheral hypomyelination (HP:0007182)4.68111597
13Abnormality of macrophages (HP:0004311)4.66044600
14Eczematoid dermatitis (HP:0000976)4.52642780
15Cerebral hypomyelination (HP:0006808)4.48164473
16Cerebral inclusion bodies (HP:0100314)4.40655681
17Orchitis (HP:0100796)4.15742410
18Obstructive lung disease (HP:0006536)4.12981744
19Chronic obstructive pulmonary disease (HP:0006510)4.12981744
20Retrobulbar optic neuritis (HP:0100654)4.03817041
21Optic neuritis (HP:0100653)4.03817041
22Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.96131886
23Spastic gait (HP:0002064)3.75361371
24Prolonged bleeding time (HP:0003010)3.72114768
25Meningitis (HP:0001287)3.71503861
26Recurrent fungal infections (HP:0002841)3.70072108
27Abnormal delayed hypersensitivity skin test (HP:0002963)3.67504838
28Abnormal auditory evoked potentials (HP:0006958)3.66775525
29Recurrent skin infections (HP:0001581)3.64497834
30Onion bulb formation (HP:0003383)3.60549471
31Petechiae (HP:0000967)3.59856138
32Mediastinal lymphadenopathy (HP:0100721)3.54871310
33Supranuclear gaze palsy (HP:0000605)3.48192525
34Recurrent gram-negative bacterial infections (HP:0005420)3.46695938
35Hypochromic microcytic anemia (HP:0004840)3.40444168
36Chronic mucocutaneous candidiasis (HP:0002728)3.40403240
37Recurrent cutaneous fungal infections (HP:0011370)3.40403240
38T lymphocytopenia (HP:0005403)3.36751805
39Abnormality of T cell number (HP:0011839)3.34833667
40Encephalitis (HP:0002383)3.34267329
41Akinesia (HP:0002304)3.33889985
42Vasculitis (HP:0002633)3.32075218
43Purpura (HP:0000979)3.29619128
44Autoimmune hemolytic anemia (HP:0001890)3.27297515
45Spastic paraparesis (HP:0002313)3.26447380
46Epistaxis (HP:0000421)3.23252237
47Alacrima (HP:0000522)3.19932019
48Granulocytopenia (HP:0001913)3.16405623
49Thickened helices (HP:0000391)3.15042595
50Hypoplastic pelvis (HP:0008839)3.14017627
51Abnormality of T cells (HP:0002843)3.11353105
52Dysmetria (HP:0001310)3.09966686
53Pulmonary infiltrates (HP:0002113)3.08278916
54Keratoconjunctivitis sicca (HP:0001097)3.07158375
55Chest pain (HP:0100749)3.06089470
56Increased IgM level (HP:0003496)3.03208683
57Intention tremor (HP:0002080)3.02109147
58Autoamputation (HP:0001218)2.99667245
59Increased IgE level (HP:0003212)2.95555122
60Gastrointestinal infarctions (HP:0005244)2.95099713
61Slow saccadic eye movements (HP:0000514)2.95006507
62Autoimmune thrombocytopenia (HP:0001973)2.91375668
63Abnormality of the heme biosynthetic pathway (HP:0010472)2.86970657
64Urticaria (HP:0001025)2.86511321
65Hemoptysis (HP:0002105)2.86300816
66Hypochromic anemia (HP:0001931)2.85946899
67IgM deficiency (HP:0002850)2.85359140
68Leukocytosis (HP:0001974)2.85201600
69Insidious onset (HP:0003587)2.84189577
70Termporal pattern (HP:0011008)2.84189577
71Increased serum pyruvate (HP:0003542)2.84043923
72Abnormality of glycolysis (HP:0004366)2.84043923
73Recurrent viral infections (HP:0004429)2.83937053
74Abnormality of liposaccharide metabolism (HP:0010968)2.81910157
75Abnormality of glycosphingolipid metabolism (HP:0004343)2.81910157
76Abnormality of glycolipid metabolism (HP:0010969)2.81910157
77Abnormality of T cell physiology (HP:0011840)2.81190994
78Eosinophilia (HP:0001880)2.80957274
79Leukodystrophy (HP:0002415)2.80631387
80Myokymia (HP:0002411)2.80523243
81Congenital ichthyosiform erythroderma (HP:0007431)2.79552261
82CNS hypomyelination (HP:0003429)2.79328094
83Pulmonary embolism (HP:0002204)2.77358430
84Keratoconjunctivitis (HP:0001096)2.76430981
85Panhypogammaglobulinemia (HP:0003139)2.73431662
86Abnormality of the phalanges of the 2nd finger (HP:0009541)2.71593936
87Spontaneous hematomas (HP:0007420)2.70958531
88Gingival bleeding (HP:0000225)2.67987320
89Abnormality of the prostate (HP:0008775)2.64641173
90Muscle fiber splitting (HP:0003555)2.64243157
91Stridor (HP:0010307)2.62192990
92Anteriorly placed anus (HP:0001545)2.62111640
93Absent septum pellucidum (HP:0001331)2.61852755
94Cerebral hemorrhage (HP:0001342)2.60794616
95Arterial thrombosis (HP:0004420)2.59477674
96Gangrene (HP:0100758)2.57209339
97Agammaglobulinemia (HP:0004432)2.54218239
98Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.51290997
99Gingivitis (HP:0000230)2.49059914
100Hypergammaglobulinemia (HP:0010702)2.48656507
101Pustule (HP:0200039)2.48643555
102Decreased lacrimation (HP:0000633)2.48540439
103Inflammation of the large intestine (HP:0002037)2.47681397
104Cellulitis (HP:0100658)2.46970740
105IgG deficiency (HP:0004315)2.43984081
106Renal Fanconi syndrome (HP:0001994)2.40319113
107Episodic fever (HP:0001954)2.39655547
108Abnormality of eosinophils (HP:0001879)2.37304299
109Morphological abnormality of the inner ear (HP:0011390)2.37025901
110Premature skin wrinkling (HP:0100678)2.36751910
111Microcytic anemia (HP:0001935)2.36500801
112Joint swelling (HP:0001386)2.35264267
113Gastrointestinal inflammation (HP:0004386)2.34808338
114Retinal dysplasia (HP:0007973)2.33207099
115Segmental peripheral demyelination/remyelination (HP:0003481)2.32765060
116Anorexia (HP:0002039)2.31832063
117Severe combined immunodeficiency (HP:0004430)2.30039329
118Abnormality of B cell number (HP:0010975)2.29619010
119Abnormality of the pleura (HP:0002103)2.29487327
120Increased cerebral lipofuscin (HP:0011813)2.25783184
121Ankle clonus (HP:0011448)2.25111075
122Scanning speech (HP:0002168)2.23739528
123Glomerulopathy (HP:0100820)2.22190182
124Abnormality of the septum pellucidum (HP:0007375)2.20561928
125Hepatosplenomegaly (HP:0001433)2.20296187
126Skin rash (HP:0000988)2.19680370
127Systemic lupus erythematosus (HP:0002725)2.19612273
128Lymphopenia (HP:0001888)2.19553832
129Amyloidosis (HP:0011034)2.17984079
130Split foot (HP:0001839)2.17925623
131Recurrent bronchitis (HP:0002837)2.17785346
132Coronal craniosynostosis (HP:0004440)2.17645649
133Loss of speech (HP:0002371)2.17535077
134B lymphocytopenia (HP:0010976)2.15219432
135Foot dorsiflexor weakness (HP:0009027)2.13323561
136Polyneuropathy (HP:0001271)2.12970087
137Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.11190565
138Abnormality of cells of the lymphoid lineage (HP:0012140)2.10092550
139Abnormality of iron homeostasis (HP:0011031)2.09778389
140Increased serum ferritin (HP:0003281)2.09510471
141Decreased motor nerve conduction velocity (HP:0003431)2.08673724
142White forelock (HP:0002211)2.08539840
143Dysostosis multiplex (HP:0000943)2.08174474
144Aplastic anemia (HP:0001915)2.06135765
145Adrenal hypoplasia (HP:0000835)2.06021465
146Increased neuronal autofluorescent lipopigment (HP:0002074)2.04792990
147Barrel-shaped chest (HP:0001552)2.04587973
148Abnormality of the pericardium (HP:0001697)2.03341587
149Aplasia involving bones of the extremities (HP:0009825)2.01683137
150Aplasia involving bones of the upper limbs (HP:0009823)2.01683137
151Aplasia of the phalanges of the hand (HP:0009802)2.01683137
152Clumsiness (HP:0002312)2.01636483
153Patchy hypopigmentation of hair (HP:0011365)2.01450592
154Poor speech (HP:0002465)2.01319679
155Colitis (HP:0002583)1.99495224
156Partial agenesis of the corpus callosum (HP:0001338)1.97956180
157Osteomyelitis (HP:0002754)1.96640420
158Premature loss of primary teeth (HP:0006323)1.95812190
159Vacuolated lymphocytes (HP:0001922)1.94372757
160Paraparesis (HP:0002385)1.94291717
161Infantile muscular hypotonia (HP:0008947)1.93863364
162Gowers sign (HP:0003391)1.93535316
163Spastic tetraparesis (HP:0001285)1.93028316
164Combined immunodeficiency (HP:0005387)1.92715326
165Abnormality of the middle phalanges of the toes (HP:0010183)1.91535316
166Humeroradial synostosis (HP:0003041)1.91233744
167Synostosis involving the elbow (HP:0003938)1.91233744
168Partial duplication of thumb phalanx (HP:0009944)1.89979559
169Abnormality of the foot musculature (HP:0001436)1.89975332
170Stenosis of the external auditory canal (HP:0000402)1.89887148
171Pheochromocytoma (HP:0002666)1.88773325
172Erythroderma (HP:0001019)1.88276385
173Cupped ear (HP:0000378)1.87830130
174Abnormal gallbladder physiology (HP:0012438)1.87291888
175Cholecystitis (HP:0001082)1.87291888
176Metabolic alkalosis (HP:0200114)1.86980834
177Diminished movement (HP:0002374)1.86183370
178Lower limb muscle weakness (HP:0007340)1.85552666
179Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.83373772
180Hypoplasia of the iris (HP:0007676)1.83112157
181Hyporeflexia of lower limbs (HP:0002600)1.79962433
182Generalized myoclonic seizures (HP:0002123)1.78966160
183Increased circulating renin level (HP:0000848)1.77484388
184Chin dimple (HP:0010751)1.76022952
185Prolonged neonatal jaundice (HP:0006579)1.74808915
186Methylmalonic acidemia (HP:0002912)1.74734368
187Megalencephaly (HP:0001355)1.72551023
188Hypokalemic alkalosis (HP:0001949)1.71666606
189Urinary incontinence (HP:0000020)1.71369672
190Esophageal atresia (HP:0002032)1.70921899
191Irregular epiphyses (HP:0010582)1.70573595
192Hypophosphatemic rickets (HP:0004912)1.68079903
193Hypomagnesemia (HP:0002917)1.67635345
194Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.67312818
195Absent epiphyses (HP:0010577)1.67312818
196Anomalous pulmonary venous return (HP:0010772)1.66797220
197Progressive inability to walk (HP:0002505)1.64450886
198Progressive neurologic deterioration (HP:0002344)1.64225941

Predicted kinase interactions (KEA)

RankGene SetZ-score
1STK396.33000985
2RIPK44.65585147
3OXSR14.58963485
4TXK4.20347460
5MAP4K13.74484445
6FES3.06621835
7BCR3.05978972
8EPHB12.94844792
9CDK192.65976236
10PBK2.60325179
11MAP2K32.59781682
12CSK2.57143029
13BLK2.56661582
14PKN12.53042257
15MET2.48112726
16WNK42.46654807
17LIMK12.31353643
18IRAK42.26656394
19SYK2.21540887
20BTK2.19849702
21TNK22.15189536
22CSNK1G32.14330252
23MAPKAPK52.11157971
24ERN12.08296086
25TBK12.07620077
26ZAP702.07097454
27TYK22.05728114
28FGFR22.01649063
29CSNK1A1L2.01640413
30GRK61.98566713
31NEK61.98389992
32WNK11.94251969
33PRPF4B1.84280405
34CSNK1G11.83700447
35IKBKE1.69308779
36CSF1R1.69014282
37JAK31.67357910
38TEC1.66090738
39MST41.60479216
40MAP3K111.59245842
41HCK1.58064291
42LYN1.54789757
43ARAF1.53689399
44CSNK1G21.53396879
45ROCK21.50508800
46TAOK21.50263301
47MAP3K131.49272122
48ERBB41.46276834
49CAMK2B1.46252647
50LCK1.44572332
51TNIK1.44075751
52MAP3K31.43861242
53KDR1.42591123
54UHMK11.39585939
55TESK21.38550399
56MARK31.38143280
57ICK1.37521173
58PNCK1.36139506
59TAOK11.35034184
60PAK61.34061492
61CLK11.33880236
62MAP3K141.33840881
63NTRK11.31829933
64JAK21.29335365
65FGR1.26582817
66IKBKB1.24207235
67KSR21.22561610
68KIT1.20058204
69TRPM71.19892608
70CAMK2D1.17062526
71MAP3K11.15877506
72MUSK1.12727698
73DYRK21.11211273
74EPHA41.09685350
75JAK11.07856290
76PIK3CG1.07780268
77PINK11.00190099
78MOS0.95238036
79MAP3K90.95068013
80SGK4940.93363927
81SGK2230.93363927
82PAK30.93343846
83CAMK2G0.92867874
84CDK140.91075418
85BCKDK0.89533854
86PRKCQ0.88395749
87MAP2K60.87107585
88BMPR1B0.86936417
89MAPK120.85155389
90MAPK150.84823119
91SIK30.84043641
92TYRO30.82309538
93MARK10.82261124
94CDK150.80281375
95MATK0.77436709
96CASK0.75870111
97EIF2AK10.75756239
98CAMK2A0.74559875
99CDK180.74336171
100MAP3K50.73110991
101CDK11A0.71121442
102SCYL20.69438371
103NME20.67854587
104MAPKAPK30.66470285
105HIPK20.65798218
106BRAF0.65600777
107CDK50.65302708
108GRK70.65238507
109IRAK30.63202676
110BMX0.62111821
111CSNK1D0.62043524
112RAF10.59384190
113PIM10.58282675
114MARK20.57467010
115RPS6KA50.56625390
116PDPK10.55478428
117PRKD10.55401100
118MAPKAPK20.54221740
119MAP3K120.53048220
120MAPK110.51859586
121PHKG20.51456566
122PHKG10.51456566
123BMPR20.51100674
124TESK10.50507848
125ITK0.49106684
126PTK2B0.48161005
127MELK0.47016525
128PRKCH0.47006133
129DAPK10.46739559
130FYN0.45595911
131PRKCE0.44678919
132PRKG10.43624967
133PAK10.42540009
134CSNK1A10.42490528
135LRRK20.42247358
136CAMKK20.42021620
137TGFBR20.41974337
138STK100.41791672
139DDR20.41614614
140VRK20.41071030
141MAP3K60.40346703
142GRK50.40178123
143PIK3CA0.39700227
144PRKCD0.37769656
145PRKACB0.36756634
146IRAK10.36311773
147BUB10.35599318
148STK110.34900264
149ILK0.34808535
150EIF2AK30.32646612
151MAP2K20.32146467
152SMG10.31384567
153MAPK70.31359876
154MYLK0.31202787
155CAMKK10.30769989
156NUAK10.28975246
157DAPK30.28783176
158IRAK20.28529772
159GSK3A0.25998089
160CSNK1E0.25976770
161MAPK40.25152923
162DAPK20.25051639
163NTRK20.24776705
164TAOK30.24172320
165PRKD20.24019987
166OBSCN0.23171902
167MAPK130.23110572
168KSR10.22862538
169ABL10.22585686
170PDK10.22182584
171ABL20.21223176
172YES10.21037816
173PRKACA0.20831611
174NME10.20055914

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.04085800
2Steroid biosynthesis_Homo sapiens_hsa001005.00745998
3Fatty acid elongation_Homo sapiens_hsa000624.40786005
4Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005633.54872449
5Primary immunodeficiency_Homo sapiens_hsa053403.43276537
6Ether lipid metabolism_Homo sapiens_hsa005653.39918384
7Allograft rejection_Homo sapiens_hsa053303.38150337
8Graft-versus-host disease_Homo sapiens_hsa053323.30865623
9Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.26063479
10Staphylococcus aureus infection_Homo sapiens_hsa051502.84028427
11Leishmaniasis_Homo sapiens_hsa051402.74629464
12Asthma_Homo sapiens_hsa053102.57631629
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.53743936
14Osteoclast differentiation_Homo sapiens_hsa043802.49275511
15Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.48522262
16Antigen processing and presentation_Homo sapiens_hsa046122.44628651
17Protein export_Homo sapiens_hsa030602.43097476
18Type I diabetes mellitus_Homo sapiens_hsa049402.37597863
19Vitamin B6 metabolism_Homo sapiens_hsa007502.34409353
20Hematopoietic cell lineage_Homo sapiens_hsa046402.31172569
21Intestinal immune network for IgA production_Homo sapiens_hsa046722.28480381
22Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.26369576
23Oxidative phosphorylation_Homo sapiens_hsa001902.16403816
24Sphingolipid metabolism_Homo sapiens_hsa006002.09255451
25Toll-like receptor signaling pathway_Homo sapiens_hsa046202.08296890
26Linoleic acid metabolism_Homo sapiens_hsa005911.98622118
27Histidine metabolism_Homo sapiens_hsa003401.96000796
28Tuberculosis_Homo sapiens_hsa051521.94023588
29Sulfur metabolism_Homo sapiens_hsa009201.93818891
30Viral myocarditis_Homo sapiens_hsa054161.90919790
31Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.87290735
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.86878167
33T cell receptor signaling pathway_Homo sapiens_hsa046601.86526439
34B cell receptor signaling pathway_Homo sapiens_hsa046621.79805922
35Measles_Homo sapiens_hsa051621.77408598
36alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.76830497
37Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.73618082
38Axon guidance_Homo sapiens_hsa043601.73355443
39NOD-like receptor signaling pathway_Homo sapiens_hsa046211.63508709
40Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.57642686
41Chemokine signaling pathway_Homo sapiens_hsa040621.50620991
42Parkinsons disease_Homo sapiens_hsa050121.41787694
43Platelet activation_Homo sapiens_hsa046111.40147300
44Influenza A_Homo sapiens_hsa051641.39823071
45Arginine and proline metabolism_Homo sapiens_hsa003301.39482117
46Toxoplasmosis_Homo sapiens_hsa051451.39051879
47Alzheimers disease_Homo sapiens_hsa050101.38426102
48RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.37832638
49Herpes simplex infection_Homo sapiens_hsa051681.37301091
50Other glycan degradation_Homo sapiens_hsa005111.35648888
51Renal cell carcinoma_Homo sapiens_hsa052111.34809613
52Legionellosis_Homo sapiens_hsa051341.34362467
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.32364437
54Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.31348443
55Ovarian steroidogenesis_Homo sapiens_hsa049131.28963744
56Salmonella infection_Homo sapiens_hsa051321.28524424
57Butanoate metabolism_Homo sapiens_hsa006501.25226893
58African trypanosomiasis_Homo sapiens_hsa051431.22616906
59Pertussis_Homo sapiens_hsa051331.21334299
60Jak-STAT signaling pathway_Homo sapiens_hsa046301.20341778
61Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.18647545
62Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.13230178
63Shigellosis_Homo sapiens_hsa051311.11495639
64Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.10363788
65Serotonergic synapse_Homo sapiens_hsa047261.05618149
66TNF signaling pathway_Homo sapiens_hsa046681.05143810
67Tight junction_Homo sapiens_hsa045301.04231175
68Acute myeloid leukemia_Homo sapiens_hsa052211.04035780
69Glutathione metabolism_Homo sapiens_hsa004801.03073955
70Long-term depression_Homo sapiens_hsa047301.00405707
71Arachidonic acid metabolism_Homo sapiens_hsa005901.00183691
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.98215567
73Apoptosis_Homo sapiens_hsa042100.97761835
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.95921723
75Leukocyte transendothelial migration_Homo sapiens_hsa046700.88846816
76Glutamatergic synapse_Homo sapiens_hsa047240.87991623
77Autoimmune thyroid disease_Homo sapiens_hsa053200.86779906
78Sphingolipid signaling pathway_Homo sapiens_hsa040710.86576682
79Dorso-ventral axis formation_Homo sapiens_hsa043200.85909246
80Vibrio cholerae infection_Homo sapiens_hsa051100.82763173
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.81109028
82Cardiac muscle contraction_Homo sapiens_hsa042600.81044058
83Folate biosynthesis_Homo sapiens_hsa007900.80989601
84Rheumatoid arthritis_Homo sapiens_hsa053230.80603063
85Collecting duct acid secretion_Homo sapiens_hsa049660.80398834
86Epstein-Barr virus infection_Homo sapiens_hsa051690.80200886
87Proteasome_Homo sapiens_hsa030500.79880051
88Huntingtons disease_Homo sapiens_hsa050160.78612444
89Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78163512
90Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77728202
91Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.77389532
92GABAergic synapse_Homo sapiens_hsa047270.73583834
93Hepatitis B_Homo sapiens_hsa051610.73024143
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.72428578
95Basal transcription factors_Homo sapiens_hsa030220.69623320
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.69502851
97Ras signaling pathway_Homo sapiens_hsa040140.69415433
98Glycerophospholipid metabolism_Homo sapiens_hsa005640.69086879
99Systemic lupus erythematosus_Homo sapiens_hsa053220.68997610
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.68210493
101Hepatitis C_Homo sapiens_hsa051600.67807332
102Malaria_Homo sapiens_hsa051440.66775601
103Vascular smooth muscle contraction_Homo sapiens_hsa042700.65469773
104Cocaine addiction_Homo sapiens_hsa050300.65439656
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.65435964
106Endocytosis_Homo sapiens_hsa041440.65084196
107Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.64851078
108Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63196189
109Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.62858345
110Non-small cell lung cancer_Homo sapiens_hsa052230.62360758
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.61717783
112ErbB signaling pathway_Homo sapiens_hsa040120.59992194
113Pancreatic cancer_Homo sapiens_hsa052120.59452838
114Peroxisome_Homo sapiens_hsa041460.58309104
115ECM-receptor interaction_Homo sapiens_hsa045120.55056865
116Propanoate metabolism_Homo sapiens_hsa006400.54694814
117Morphine addiction_Homo sapiens_hsa050320.53723457
118Chemical carcinogenesis_Homo sapiens_hsa052040.53697318
119Fatty acid metabolism_Homo sapiens_hsa012120.53283306
120Lysosome_Homo sapiens_hsa041420.51284238
121VEGF signaling pathway_Homo sapiens_hsa043700.50693195
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.49993631
123Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.49649079
124Hedgehog signaling pathway_Homo sapiens_hsa043400.49550642
125Metabolic pathways_Homo sapiens_hsa011000.48769054
126Viral carcinogenesis_Homo sapiens_hsa052030.48122779
127HTLV-I infection_Homo sapiens_hsa051660.47828858
128Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.45476313
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.44168746
130Nitrogen metabolism_Homo sapiens_hsa009100.44042934
131Tyrosine metabolism_Homo sapiens_hsa003500.43728543
132Phototransduction_Homo sapiens_hsa047440.42919810
133Mineral absorption_Homo sapiens_hsa049780.42904377
134Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42702538
135Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.42196288
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42131522
137Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.40705793
138Non-homologous end-joining_Homo sapiens_hsa034500.40447679
139Phagosome_Homo sapiens_hsa041450.39561195
140Adipocytokine signaling pathway_Homo sapiens_hsa049200.37457401
141Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.37168636
142Pentose phosphate pathway_Homo sapiens_hsa000300.35994521
143Choline metabolism in cancer_Homo sapiens_hsa052310.35473666
144Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.34567573
145Retinol metabolism_Homo sapiens_hsa008300.32065635
146Chronic myeloid leukemia_Homo sapiens_hsa052200.31999967
147RNA polymerase_Homo sapiens_hsa030200.28565653
148Pancreatic secretion_Homo sapiens_hsa049720.27562671
149Neurotrophin signaling pathway_Homo sapiens_hsa047220.26232523
150Salivary secretion_Homo sapiens_hsa049700.26205613
151PI3K-Akt signaling pathway_Homo sapiens_hsa041510.25896441
152Wnt signaling pathway_Homo sapiens_hsa043100.25253129
153Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.25036526
154Vitamin digestion and absorption_Homo sapiens_hsa049770.23904635
155Dopaminergic synapse_Homo sapiens_hsa047280.23850542
156Amoebiasis_Homo sapiens_hsa051460.23009578
157Complement and coagulation cascades_Homo sapiens_hsa046100.22905342
158Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.22528776
159Gap junction_Homo sapiens_hsa045400.21744157
160MAPK signaling pathway_Homo sapiens_hsa040100.21314801
161cAMP signaling pathway_Homo sapiens_hsa040240.20620975
162Circadian entrainment_Homo sapiens_hsa047130.20325070
163Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.20237411
164Cholinergic synapse_Homo sapiens_hsa047250.19799582
165Fatty acid biosynthesis_Homo sapiens_hsa000610.19225731
166Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.18993606
167Regulation of autophagy_Homo sapiens_hsa041400.18034093
168Carbohydrate digestion and absorption_Homo sapiens_hsa049730.17059033
169Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.14436859
170Phosphatidylinositol signaling system_Homo sapiens_hsa040700.13895498
171HIF-1 signaling pathway_Homo sapiens_hsa040660.13634353
172Drug metabolism - other enzymes_Homo sapiens_hsa009830.13559262
173FoxO signaling pathway_Homo sapiens_hsa040680.11932930
174Galactose metabolism_Homo sapiens_hsa000520.10690365
175Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.09639246
176Prolactin signaling pathway_Homo sapiens_hsa049170.09176236

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