NIP7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)4.98979744
2DNA deamination (GO:0045006)4.85841532
3maturation of SSU-rRNA (GO:0030490)4.83325285
4ribosomal small subunit biogenesis (GO:0042274)4.60967964
5ribosomal small subunit assembly (GO:0000028)4.45244774
6ribosomal large subunit biogenesis (GO:0042273)4.42842201
7nucleobase biosynthetic process (GO:0046112)4.42711928
8ribonucleoprotein complex biogenesis (GO:0022613)4.42213954
9DNA strand elongation involved in DNA replication (GO:0006271)4.41580456
10ribosome biogenesis (GO:0042254)4.41500661
11purine nucleobase biosynthetic process (GO:0009113)4.39657070
12transcription elongation from RNA polymerase III promoter (GO:0006385)4.39473742
13termination of RNA polymerase III transcription (GO:0006386)4.39473742
14DNA replication initiation (GO:0006270)4.38792337
15telomere maintenance via semi-conservative replication (GO:0032201)4.34223397
16rRNA modification (GO:0000154)4.31411482
17DNA replication checkpoint (GO:0000076)4.25631968
18DNA strand elongation (GO:0022616)4.20472322
19formation of translation preinitiation complex (GO:0001731)4.05712191
20mitotic metaphase plate congression (GO:0007080)4.02293122
21rRNA processing (GO:0006364)3.95944636
22spliceosomal snRNP assembly (GO:0000387)3.95306617
237-methylguanosine mRNA capping (GO:0006370)3.91179084
24negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.90494500
25viral transcription (GO:0019083)3.89013515
26telomere maintenance via recombination (GO:0000722)3.88414913
27mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.88306709
28translational termination (GO:0006415)3.87296854
29pseudouridine synthesis (GO:0001522)3.85943699
307-methylguanosine RNA capping (GO:0009452)3.85456638
31RNA capping (GO:0036260)3.85456638
32CENP-A containing nucleosome assembly (GO:0034080)3.83444739
33rRNA metabolic process (GO:0016072)3.82926228
34termination of RNA polymerase I transcription (GO:0006363)3.79377622
35positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.78510214
36anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.77511827
37transcription elongation from RNA polymerase I promoter (GO:0006362)3.75412487
38regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.75181867
39* ribosome assembly (GO:0042255)3.73796847
40transcription from RNA polymerase I promoter (GO:0006360)3.73412608
41transcription-coupled nucleotide-excision repair (GO:0006283)3.72274339
42chromatin remodeling at centromere (GO:0031055)3.71666793
43translational initiation (GO:0006413)3.60706777
44regulation of mitochondrial translation (GO:0070129)3.60610618
45chaperone-mediated protein transport (GO:0072321)3.60285269
46telomere maintenance via telomere lengthening (GO:0010833)3.59387604
47IMP metabolic process (GO:0046040)3.58812705
48negative regulation of ligase activity (GO:0051352)3.56989451
49negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.56989451
50regulation of nuclear cell cycle DNA replication (GO:0033262)3.56893130
51folic acid-containing compound biosynthetic process (GO:0009396)3.55832008
52establishment of integrated proviral latency (GO:0075713)3.55658906
53mitotic recombination (GO:0006312)3.53095029
54establishment of viral latency (GO:0019043)3.51842830
55cellular component biogenesis (GO:0044085)3.49265510
56translational elongation (GO:0006414)3.48827024
57maturation of 5.8S rRNA (GO:0000460)3.47209627
58protein localization to kinetochore (GO:0034501)3.45501234
59spliceosomal complex assembly (GO:0000245)3.43069068
60IMP biosynthetic process (GO:0006188)3.39513562
61metaphase plate congression (GO:0051310)3.39075766
62signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.39056434
63signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.39056434
64signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.39056434
65rRNA methylation (GO:0031167)3.37778327
66DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.36226435
67DNA catabolic process, exonucleolytic (GO:0000738)3.35737358
68kinetochore assembly (GO:0051382)3.35136904
69signal transduction involved in DNA integrity checkpoint (GO:0072401)3.34628434
70signal transduction involved in DNA damage checkpoint (GO:0072422)3.34628434
71translation (GO:0006412)3.33694606
72DNA replication-independent nucleosome assembly (GO:0006336)3.33251213
73DNA replication-independent nucleosome organization (GO:0034724)3.33251213
74nucleotide-excision repair, DNA gap filling (GO:0006297)3.32717498
75SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.32678226
76positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.32520681
77transcription initiation from RNA polymerase I promoter (GO:0006361)3.32153988
78regulation of cellular amino acid metabolic process (GO:0006521)3.31890908
79signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.31387823
80intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.31387823
81regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.30627536
82signal transduction involved in cell cycle checkpoint (GO:0072395)3.30226371
83energy coupled proton transport, down electrochemical gradient (GO:0015985)3.28999359
84ATP synthesis coupled proton transport (GO:0015986)3.28999359
85exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.28458478
86cotranslational protein targeting to membrane (GO:0006613)3.27575911
87DNA replication-dependent nucleosome organization (GO:0034723)3.25509505
88DNA replication-dependent nucleosome assembly (GO:0006335)3.25509505
89protein targeting to ER (GO:0045047)3.24030583
90regulation of ubiquitin-protein transferase activity (GO:0051438)3.23827788
91deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.23756402
92cell cycle G1/S phase transition (GO:0044843)3.23676578
93G1/S transition of mitotic cell cycle (GO:0000082)3.23676578
94mitochondrial RNA metabolic process (GO:0000959)3.23305659
95protein targeting to mitochondrion (GO:0006626)3.23303440
96DNA double-strand break processing (GO:0000729)3.22910576
97establishment of protein localization to mitochondrial membrane (GO:0090151)3.22652914
98protein localization to chromosome, centromeric region (GO:0071459)3.21555942
99L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.21228327
100kinetochore organization (GO:0051383)3.20770954
101nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.18509871
102positive regulation of ligase activity (GO:0051351)3.18431215
103deoxyribonucleotide biosynthetic process (GO:0009263)3.18165996
104mitotic sister chromatid segregation (GO:0000070)3.17492915
105regulation of double-strand break repair via homologous recombination (GO:0010569)3.16641655
106nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.16246922
107histone exchange (GO:0043486)3.14288351
108regulation of ligase activity (GO:0051340)3.14152628
109DNA damage response, detection of DNA damage (GO:0042769)3.14068044
110transcription from mitochondrial promoter (GO:0006390)3.13227374
111mitotic nuclear envelope disassembly (GO:0007077)3.12020675
112ncRNA processing (GO:0034470)3.10811617
113nuclear pore complex assembly (GO:0051292)3.10592985
114viral mRNA export from host cell nucleus (GO:0046784)3.10165717
115cellular protein complex disassembly (GO:0043624)3.09618532
116protein localization to endoplasmic reticulum (GO:0070972)3.07714146
117histone mRNA metabolic process (GO:0008334)3.07290916
118ncRNA metabolic process (GO:0034660)3.06550411
119establishment of protein localization to endoplasmic reticulum (GO:0072599)3.06100401
120DNA-templated transcription, termination (GO:0006353)3.05706476
121cullin deneddylation (GO:0010388)3.05626826
122DNA unwinding involved in DNA replication (GO:0006268)3.03737585
123amino acid activation (GO:0043038)3.02598999
124tRNA aminoacylation (GO:0043039)3.02598999
125tRNA aminoacylation for protein translation (GO:0006418)3.02334231
126spindle checkpoint (GO:0031577)3.01787809
127pteridine-containing compound biosynthetic process (GO:0042559)3.01001494
128protein deneddylation (GO:0000338)2.99319467
129mitotic spindle checkpoint (GO:0071174)2.96828176
130DNA ligation (GO:0006266)2.96102756

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.80713136
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.69487472
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.22309525
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.82766251
5EST1_17652178_ChIP-ChIP_JURKAT_Human3.74606700
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.62154600
7* ETS1_20019798_ChIP-Seq_JURKAT_Human3.48897819
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.39956740
9MYC_19079543_ChIP-ChIP_MESCs_Mouse3.32436950
10E2F4_17652178_ChIP-ChIP_JURKAT_Human3.32076861
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.24004750
12CREB1_15753290_ChIP-ChIP_HEK293T_Human3.14802528
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse3.13629230
14* MYC_19030024_ChIP-ChIP_MESCs_Mouse3.12969900
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.82609216
16CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.75661196
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.73989405
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.70936827
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.62968693
20VDR_23849224_ChIP-Seq_CD4+_Human2.60803898
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.58530777
22CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.56846739
23* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.51413689
24NELFA_20434984_ChIP-Seq_ESCs_Mouse2.46901223
25XRN2_22483619_ChIP-Seq_HELA_Human2.45970339
26ELF1_17652178_ChIP-ChIP_JURKAT_Human2.28784595
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.27080187
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.21131952
29DCP1A_22483619_ChIP-Seq_HELA_Human2.15148277
30MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.12734703
31* FOXP3_21729870_ChIP-Seq_TREG_Human2.09471731
32YY1_21170310_ChIP-Seq_MESCs_Mouse2.04546678
33NANOG_18555785_ChIP-Seq_MESCs_Mouse2.02614644
34ELK1_19687146_ChIP-ChIP_HELA_Human2.01965813
35* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.01855344
36* TTF2_22483619_ChIP-Seq_HELA_Human2.00234692
37GABP_19822575_ChIP-Seq_HepG2_Human1.96740893
38* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89968596
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86754175
40SRF_21415370_ChIP-Seq_HL-1_Mouse1.83259675
41* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.75829489
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75496729
43* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.74388204
44PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73802623
45AR_21909140_ChIP-Seq_LNCAP_Human1.70340347
46POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.61188958
47SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.58379527
48* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56709208
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.56170616
50E2F1_21310950_ChIP-Seq_MCF-7_Human1.54380572
51KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.50463921
52HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48205465
53PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.44654884
54NOTCH1_21737748_ChIP-Seq_TLL_Human1.41053275
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.37050333
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.35148204
57CIITA_25753668_ChIP-Seq_RAJI_Human1.33607896
58POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.33033013
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32305656
60SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.32060553
61* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.29792355
62TP63_19390658_ChIP-ChIP_HaCaT_Human1.28144222
63KDM5A_27292631_Chip-Seq_BREAST_Human1.28064583
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26507259
65* ELK1_22589737_ChIP-Seq_MCF10A_Human1.26059322
66HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25634626
67KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25024546
68* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21710445
69DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.19451565
70STAT3_1855785_ChIP-Seq_MESCs_Mouse1.18864350
71KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.18825139
72KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.18825139
73KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.18825139
74HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.16309590
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.13801121
76* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.13237578
77TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.12329933
78MYC_18940864_ChIP-ChIP_HL60_Human1.12005278
79ERG_20887958_ChIP-Seq_HPC-7_Mouse1.11579158
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04764624
81CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03747565
82NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.01553526
83BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01145997
84SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.00665091
85RBPJ_22232070_ChIP-Seq_NCS_Mouse0.98291865
86* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.97121408
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.96569935
88* KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96478782
89NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.95253271
90TCF3_18692474_ChIP-Seq_MEFs_Mouse0.94645667
91PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.91771670
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89692579
93DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88335359
94CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.88289508
95SOX17_20123909_ChIP-Seq_XEN_Mouse0.88041658
96SOX2_18692474_ChIP-Seq_MEFs_Mouse0.87194598
97TFEB_21752829_ChIP-Seq_HELA_Human0.85793851
98SALL1_21062744_ChIP-ChIP_HESCs_Human0.84197565
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81925559
100KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.81209782
101OCT4_18692474_ChIP-Seq_MEFs_Mouse0.80738877
102ELF5_23300383_ChIP-Seq_T47D_Human0.80250529
103ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.80180916
104IRF1_19129219_ChIP-ChIP_H3396_Human0.78320672
105HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.78224260
106ZNF263_19887448_ChIP-Seq_K562_Human0.76822069
107* SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.76026415
108CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.75142710
109NANOG_16153702_ChIP-ChIP_HESCs_Human0.74774492
110CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.74536454
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.74300537
112* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.73356154
113EWS_26573619_Chip-Seq_HEK293_Human0.69854380
114SOX2_16153702_ChIP-ChIP_HESCs_Human0.69415041
115CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.66588814
116TBX5_21415370_ChIP-Seq_HL-1_Mouse0.64639220

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.87028856
2MP0003111_abnormal_nucleus_morphology4.58498098
3MP0004957_abnormal_blastocyst_morpholog4.46282444
4MP0010094_abnormal_chromosome_stability4.43897279
5MP0008057_abnormal_DNA_replication4.20436646
6MP0003077_abnormal_cell_cycle3.99618150
7MP0008058_abnormal_DNA_repair3.98543031
8MP0008932_abnormal_embryonic_tissue3.04054868
9MP0003718_maternal_effect2.99685108
10MP0008007_abnormal_cellular_replicative2.94628646
11MP0003786_premature_aging2.63338135
12MP0009697_abnormal_copulation2.38591955
13MP0008877_abnormal_DNA_methylation2.36971381
14MP0006292_abnormal_olfactory_placode2.28379330
15MP0003123_paternal_imprinting2.25595109
16MP0001730_embryonic_growth_arrest2.05745144
17MP0009379_abnormal_foot_pigmentation1.97870119
18MP0002254_reproductive_system_inflammat1.94017087
19MP0000350_abnormal_cell_proliferation1.88509758
20MP0003806_abnormal_nucleotide_metabolis1.88337043
21MP0003315_abnormal_perineum_morphology1.82952025
22MP0003136_yellow_coat_color1.64446634
23MP0004133_heterotaxia1.55217301
24MP0002210_abnormal_sex_determination1.50015284
25MP0002160_abnormal_reproductive_system1.47186771
26MP0003941_abnormal_skin_development1.43684933
27MP0002396_abnormal_hematopoietic_system1.43051756
28MP0005380_embryogenesis_phenotype1.40017311
29MP0001672_abnormal_embryogenesis/_devel1.40017311
30MP0000313_abnormal_cell_death1.39634923
31MP0001697_abnormal_embryo_size1.39130324
32MP0003186_abnormal_redox_activity1.37183582
33MP0002080_prenatal_lethality1.31439180
34MP0001145_abnormal_male_reproductive1.31003811
35MP0009333_abnormal_splenocyte_physiolog1.30200143
36MP0005389_reproductive_system_phenotype1.29109947
37MP0002085_abnormal_embryonic_tissue1.27886645
38MP0000490_abnormal_crypts_of1.19746244
39MP0000372_irregular_coat_pigmentation1.19281907
40MP0002102_abnormal_ear_morphology1.18776945
41MP0000566_synostosis1.18388586
42MP0002132_abnormal_respiratory_system1.17768735
43MP0001188_hyperpigmentation1.16023951
44MP0002796_impaired_skin_barrier1.15135382
45MP0001929_abnormal_gametogenesis1.13142557
46MP0000653_abnormal_sex_gland1.12849005
47MP0003984_embryonic_growth_retardation1.12742359
48MP0002019_abnormal_tumor_incidence1.11872626
49MP0005501_abnormal_skin_physiology1.10736939
50MP0001293_anophthalmia1.09912879
51MP0002088_abnormal_embryonic_growth/wei1.08536229
52MP0008260_abnormal_autophagy1.05609478
53MP0001853_heart_inflammation1.05086965
54MP0003567_abnormal_fetal_cardiomyocyte1.03112055
55MP0003950_abnormal_plasma_membrane1.02595706
56MP0003121_genomic_imprinting1.02509672
57MP0002084_abnormal_developmental_patter0.99643444
58MP0009672_abnormal_birth_weight0.99224664
59MP0001919_abnormal_reproductive_system0.99126944
60MP0006035_abnormal_mitochondrial_morpho0.98333100
61MP0005408_hypopigmentation0.98120364
62MP0010352_gastrointestinal_tract_polyps0.97301596
63MP0010307_abnormal_tumor_latency0.96997174
64MP0001529_abnormal_vocalization0.96952247
65MP0006072_abnormal_retinal_apoptosis0.95337937
66MP0002277_abnormal_respiratory_mucosa0.94555363
67MP0003890_abnormal_embryonic-extraembry0.93637531
68MP0002938_white_spotting0.93567559
69MP0001873_stomach_inflammation0.93040171
70MP0001119_abnormal_female_reproductive0.92849712
71MP0010030_abnormal_orbit_morphology0.92216689
72MP0003937_abnormal_limbs/digits/tail_de0.92086243
73MP0001661_extended_life_span0.90155511
74MP0001986_abnormal_taste_sensitivity0.89575964
75MP0005395_other_phenotype0.89096346
76MP0001764_abnormal_homeostasis0.88702628
77MP0004197_abnormal_fetal_growth/weight/0.86524795
78MP0000358_abnormal_cell_content/0.86281078
79MP0002086_abnormal_extraembryonic_tissu0.86259818
80MP0002877_abnormal_melanocyte_morpholog0.86100942
81MP0003938_abnormal_ear_development0.85848712
82MP0002111_abnormal_tail_morphology0.82654053
83MP0008995_early_reproductive_senescence0.80727592
84MP0000703_abnormal_thymus_morphology0.80225966
85MP0003763_abnormal_thymus_physiology0.79599424
86MP0003119_abnormal_digestive_system0.79355941
87MP0001286_abnormal_eye_development0.79217448
88MP0001881_abnormal_mammary_gland0.76801303
89MP0005384_cellular_phenotype0.76702740
90MP0005075_abnormal_melanosome_morpholog0.76450977
91MP0006036_abnormal_mitochondrial_physio0.75033550
92MP0005084_abnormal_gallbladder_morpholo0.73969052
93MP0001542_abnormal_bone_strength0.72557961
94MP0005377_hearing/vestibular/ear_phenot0.72381088
95MP0003878_abnormal_ear_physiology0.72381088
96MP0000689_abnormal_spleen_morphology0.71813463
97MP0003936_abnormal_reproductive_system0.71805749
98MP0002722_abnormal_immune_system0.71383673
99MP0002751_abnormal_autonomic_nervous0.70492398
100MP0001727_abnormal_embryo_implantation0.70041024
101MP0000049_abnormal_middle_ear0.68442780
102MP0001216_abnormal_epidermal_layer0.67702053
103MP0008789_abnormal_olfactory_epithelium0.67616607
104MP0003698_abnormal_male_reproductive0.67270282
105MP0005409_darkened_coat_color0.66519365
106MP0000627_abnormal_mammary_gland0.66465465
107MP0002006_tumorigenesis0.66241382
108MP0005621_abnormal_cell_physiology0.66091176
109MP0000579_abnormal_nail_morphology0.65602463
110MP0004808_abnormal_hematopoietic_stem0.65349749
111MP0008873_increased_physiological_sensi0.63283771
112MP0002095_abnormal_skin_pigmentation0.61716871
113MP0000015_abnormal_ear_pigmentation0.61166921
114MP0008875_abnormal_xenobiotic_pharmacok0.60725781
115MP0002398_abnormal_bone_marrow0.60525557
116MP0000647_abnormal_sebaceous_gland0.60256359
117MP0001485_abnormal_pinna_reflex0.60216510
118MP0001905_abnormal_dopamine_level0.59869309
119MP0002163_abnormal_gland_morphology0.59745867
120MP0005451_abnormal_body_composition0.59356423
121MP0003699_abnormal_female_reproductive0.58878572
122MP0010234_abnormal_vibrissa_follicle0.57941014
123MP0005266_abnormal_metabolism0.57567713
124MP0004381_abnormal_hair_follicle0.57286108
125MP0000858_altered_metastatic_potential0.56874319
126MP0002060_abnormal_skin_morphology0.56698831
127MP0000762_abnormal_tongue_morphology0.51009857
128MP0005410_abnormal_fertilization0.50432932
129MP0001186_pigmentation_phenotype0.50423611

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.82227195
2Breast hypoplasia (HP:0003187)5.02385403
3Cerebral hypomyelination (HP:0006808)4.26529166
4Reticulocytopenia (HP:0001896)4.23815139
5Abnormality of cells of the erythroid lineage (HP:0012130)3.95415362
6Abnormal number of erythroid precursors (HP:0012131)3.76316927
7Carpal bone hypoplasia (HP:0001498)3.74125679
8Rough bone trabeculation (HP:0100670)3.64758658
9Chromosomal breakage induced by crosslinking agents (HP:0003221)3.58158416
10Acute encephalopathy (HP:0006846)3.52878212
11Oral leukoplakia (HP:0002745)3.52229467
12Chromsome breakage (HP:0040012)3.46913402
13Macrocytic anemia (HP:0001972)3.27729674
14Patellar aplasia (HP:0006443)3.20238667
15Muscle abnormality related to mitochondrial dysfunction (HP:0003800)3.15816208
16Abnormality of methionine metabolism (HP:0010901)3.12602531
17Meckel diverticulum (HP:0002245)3.10852259
18Absent radius (HP:0003974)3.09133554
19Aplasia/Hypoplasia of the patella (HP:0006498)3.07263985
20Abnormality of the preputium (HP:0100587)3.05025026
21Duplicated collecting system (HP:0000081)2.94333465
22Aplasia involving forearm bones (HP:0009822)2.93068931
23Absent forearm bone (HP:0003953)2.93068931
24Progressive macrocephaly (HP:0004481)2.93006062
25Abnormality of the ileum (HP:0001549)2.92060426
26Abnormal trabecular bone morphology (HP:0100671)2.87607598
27Multiple enchondromatosis (HP:0005701)2.81536756
28Absent thumb (HP:0009777)2.80734532
29Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.75320783
30Aplastic anemia (HP:0001915)2.74284767
31Progressive external ophthalmoplegia (HP:0000590)2.73653427
32Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.73000996
333-Methylglutaconic aciduria (HP:0003535)2.71986009
34Abnormality of chromosome stability (HP:0003220)2.71417456
35Premature graying of hair (HP:0002216)2.71271336
36Supernumerary spleens (HP:0009799)2.69528346
37Reduced antithrombin III activity (HP:0001976)2.69494981
38Pallor (HP:0000980)2.68447087
39Horseshoe kidney (HP:0000085)2.61986339
40Lactic acidosis (HP:0003128)2.61872283
41Cerebral edema (HP:0002181)2.61279811
42Hepatic necrosis (HP:0002605)2.60695375
43Abnormality of the renal collecting system (HP:0004742)2.59887820
44Abnormality of the anterior horn cell (HP:0006802)2.59845815
45Degeneration of anterior horn cells (HP:0002398)2.59845815
46Bone marrow hypocellularity (HP:0005528)2.57961517
47CNS hypomyelination (HP:0003429)2.54588777
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.53507122
49Aplasia/Hypoplasia of the sacrum (HP:0008517)2.51524296
50Increased serum lactate (HP:0002151)2.51268813
51Methylmalonic acidemia (HP:0002912)2.47398979
52Amniotic constriction ring (HP:0009775)2.47006114
53Abnormality of placental membranes (HP:0011409)2.47006114
54Colon cancer (HP:0003003)2.46970838
55Secondary amenorrhea (HP:0000869)2.44103868
56Renal Fanconi syndrome (HP:0001994)2.42152432
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.41664333
58Abnormal protein N-linked glycosylation (HP:0012347)2.41664333
59Abnormal protein glycosylation (HP:0012346)2.41664333
60Abnormal glycosylation (HP:0012345)2.41664333
61Selective tooth agenesis (HP:0001592)2.40728340
62Abnormality of aspartate family amino acid metabolism (HP:0010899)2.38957458
63Abnormality of serum amino acid levels (HP:0003112)2.38827983
64Microretrognathia (HP:0000308)2.38135679
65Impulsivity (HP:0100710)2.38082063
66Triphalangeal thumb (HP:0001199)2.36649462
67Type 2 muscle fiber atrophy (HP:0003554)2.36042205
68Increased hepatocellular lipid droplets (HP:0006565)2.35983215
69Abnormality of the labia minora (HP:0012880)2.35630206
70Microvesicular hepatic steatosis (HP:0001414)2.35408882
71Premature ovarian failure (HP:0008209)2.35277657
72Acute necrotizing encephalopathy (HP:0006965)2.34460074
73Decreased activity of mitochondrial respiratory chain (HP:0008972)2.33023745
74Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.33023745
75Irregular epiphyses (HP:0010582)2.30867809
76Trismus (HP:0000211)2.28730888
77Aplasia/Hypoplasia involving the musculature (HP:0001460)2.27702295
78Type I transferrin isoform profile (HP:0003642)2.24463537
79Squamous cell carcinoma (HP:0002860)2.24233600
80Mitochondrial inheritance (HP:0001427)2.23978724
81Hypoplasia of the pons (HP:0012110)2.23909273
82Neoplasm of the pancreas (HP:0002894)2.23403046
83Abnormality of the pons (HP:0007361)2.22464260
84Muscle fiber atrophy (HP:0100295)2.20351407
85Cleft eyelid (HP:0000625)2.18594104
86Abnormality of glycolysis (HP:0004366)2.18090210
87Increased serum pyruvate (HP:0003542)2.18090210
88Methylmalonic aciduria (HP:0012120)2.17985614
89Abnormality of the duodenum (HP:0002246)2.17661990
90Cellular immunodeficiency (HP:0005374)2.17446067
91Increased CSF lactate (HP:0002490)2.17330182
92Homocystinuria (HP:0002156)2.16811314
93Abnormality of homocysteine metabolism (HP:0010919)2.16811314
94Respiratory difficulties (HP:0002880)2.16343868
95Duodenal stenosis (HP:0100867)2.15520537
96Small intestinal stenosis (HP:0012848)2.15520537
97Pancytopenia (HP:0001876)2.12925000
98Progressive muscle weakness (HP:0003323)2.12715672
99Agnosia (HP:0010524)2.12707154
100Sparse eyelashes (HP:0000653)2.12529396
101Medulloblastoma (HP:0002885)2.12073181
102Myelodysplasia (HP:0002863)2.06668202
103Respiratory failure (HP:0002878)2.03926033
104Abnormality of the carotid arteries (HP:0005344)2.03612413
105Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.03450799
106Ureteral duplication (HP:0000073)2.02998414
107Aplasia/Hypoplasia of the earlobes (HP:0009906)2.02481024
108Abnormality of alanine metabolism (HP:0010916)2.00494739
109Hyperalaninemia (HP:0003348)2.00494739
110Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.00494739
111Abnormal lung lobation (HP:0002101)2.00338093
112Hepatocellular necrosis (HP:0001404)1.99576365
113Hypoplasia of the radius (HP:0002984)1.99179287
114Aplasia/hypoplasia of the uterus (HP:0008684)1.98102847
115Tracheoesophageal fistula (HP:0002575)1.97099464
116Clubbing of toes (HP:0100760)1.95984200
11711 pairs of ribs (HP:0000878)1.95964071
118Nephroblastoma (Wilms tumor) (HP:0002667)1.95526795
119Abnormal mitochondria in muscle tissue (HP:0008316)1.95509889
120Lethargy (HP:0001254)1.95268589
121Stenosis of the external auditory canal (HP:0000402)1.95143486
122Breast aplasia (HP:0100783)1.95056211
123Leukodystrophy (HP:0002415)1.94395003
124Megaloblastic anemia (HP:0001889)1.91305976
125Abnormality of sulfur amino acid metabolism (HP:0004339)1.90441462
126Increased intramyocellular lipid droplets (HP:0012240)1.89439073
127Exercise intolerance (HP:0003546)1.89323881
128Exertional dyspnea (HP:0002875)1.89211373
129Sloping forehead (HP:0000340)1.89194764
130Asplenia (HP:0001746)1.88782091
131Aplasia/Hypoplasia of the breasts (HP:0010311)1.87604489
132Hypoplasia of the capital femoral epiphysis (HP:0003090)1.87602000
133Sensory axonal neuropathy (HP:0003390)1.86518485
134Abnormalities of placenta or umbilical cord (HP:0001194)1.86184366
135Lipid accumulation in hepatocytes (HP:0006561)1.85839164
136Glossoptosis (HP:0000162)1.85450206
137Embryonal renal neoplasm (HP:0011794)1.82668495

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.32866578
2WEE14.09674231
3PLK43.93191563
4STK163.65734880
5VRK23.49519690
6EIF2AK13.45488281
7SRPK12.94390454
8IRAK32.88858633
9CDC72.64201079
10ZAK2.63736921
11TSSK62.47060948
12EIF2AK32.34733310
13VRK12.23023810
14TTK2.19120383
15TESK22.06262338
16NME22.01576730
17EPHA21.95349953
18MKNK11.80603798
19PLK31.76399248
20PLK11.76001150
21TRIM281.73545130
22BRSK21.69142627
23TLK11.64460717
24PNCK1.61727330
25TAF11.60913477
26MKNK21.58992710
27ACVR1B1.58721091
28DYRK31.50263715
29NUAK11.46928453
30IRAK41.44829211
31MARK11.38451680
32NME11.38223829
33PBK1.38176203
34NEK21.31673361
35ATR1.29714524
36RPS6KB21.25107131
37CDK71.22920163
38AURKB1.21289215
39CHEK21.17256013
40AURKA1.16819273
41EIF2AK21.13416883
42DYRK21.05126320
43NEK11.02956315
44MST40.98200674
45SCYL20.93962875
46IRAK20.93708147
47BRSK10.93307630
48PIM20.93219232
49WNK30.92148887
50STK38L0.91686269
51KDR0.90058216
52PRKCI0.89450221
53CHEK10.87016697
54PASK0.85869586
55ERBB40.84332754
56MAP3K80.84034574
57PAK40.83197337
58AKT30.81839163
59BRAF0.80079376
60MAP3K120.78438046
61STK40.71742499
62IRAK10.71620389
63CSNK2A20.70504597
64SMG10.70115193
65RPS6KA40.70040092
66CSNK2A10.68919900
67RPS6KA50.68082354
68CCNB10.67798988
69NEK60.64425323
70STK30.64385848
71PAK10.61773061
72ATM0.59156689
73TNIK0.58394830
74MST1R0.57936233
75CDK20.55246748
76TESK10.53343235
77ABL20.52785696
78PIM10.52765260
79CDK90.51870477
80TGFBR10.50192115
81BRD40.48770352
82CDK80.47275888
83STK100.44973177
84CDK10.44519943
85LIMK10.43802876
86LATS20.42815129
87CDK40.41267682
88DAPK10.40460464
89CSNK1G30.40001721
90MUSK0.38223161
91MAP3K110.38199208
92MAP4K20.38061090
93CSNK1E0.37586248
94FGFR10.34801823
95CLK10.34400868
96BMPR1B0.33123338
97ARAF0.32946696
98IKBKB0.32480740
99ADRBK20.30453557
100BCR0.29668409
101MAP3K140.28841356
102ALK0.28266803
103ERBB30.26202369
104MELK0.25783821
105CDK30.24780730
106BLK0.24487340
107CSNK1G10.23187720
108PDK20.23087815
109MAPKAPK30.22380530
110TXK0.21897510
111YES10.21725271
112BCKDK0.21681730
113CDK60.21103247
114OXSR10.20139145
115AKT20.19925432
116TAOK20.19696835
117PRKDC0.19657111
118CSNK1A1L0.18876744
119STK240.16980213
120MARK30.15511905
121PLK20.15175288
122CDK190.14407843
123CAMK2B0.13136102
124LYN0.12979576

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.44457393
2Proteasome_Homo sapiens_hsa030504.40539623
3DNA replication_Homo sapiens_hsa030304.38721045
4Ribosome_Homo sapiens_hsa030104.12749093
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.96984661
6Mismatch repair_Homo sapiens_hsa034303.87608524
7Spliceosome_Homo sapiens_hsa030403.21878226
8Pyrimidine metabolism_Homo sapiens_hsa002402.89881449
9RNA transport_Homo sapiens_hsa030132.89527200
10Homologous recombination_Homo sapiens_hsa034402.84403612
11Nucleotide excision repair_Homo sapiens_hsa034202.81374005
12Base excision repair_Homo sapiens_hsa034102.48409383
13Fanconi anemia pathway_Homo sapiens_hsa034602.42432837
14Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.30226064
15Basal transcription factors_Homo sapiens_hsa030222.22269361
16Cell cycle_Homo sapiens_hsa041102.16903276
17One carbon pool by folate_Homo sapiens_hsa006702.12988212
18Non-homologous end-joining_Homo sapiens_hsa034501.88877020
19RNA degradation_Homo sapiens_hsa030181.84340058
20Purine metabolism_Homo sapiens_hsa002301.69602002
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.64918385
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.62694992
23Oxidative phosphorylation_Homo sapiens_hsa001901.54079537
24Parkinsons disease_Homo sapiens_hsa050121.41314719
25p53 signaling pathway_Homo sapiens_hsa041151.39126678
26Huntingtons disease_Homo sapiens_hsa050161.37926607
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.33533606
28Protein export_Homo sapiens_hsa030601.32410752
29mRNA surveillance pathway_Homo sapiens_hsa030151.29390149
30Vitamin B6 metabolism_Homo sapiens_hsa007501.28069357
31Pyruvate metabolism_Homo sapiens_hsa006201.27274638
32Epstein-Barr virus infection_Homo sapiens_hsa051691.26589403
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.21671313
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04977309
35Propanoate metabolism_Homo sapiens_hsa006401.02257842
36Fatty acid elongation_Homo sapiens_hsa000620.97650354
37Folate biosynthesis_Homo sapiens_hsa007900.93308456
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.93193966
39Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.89878218
40Cysteine and methionine metabolism_Homo sapiens_hsa002700.83479628
41Systemic lupus erythematosus_Homo sapiens_hsa053220.81496604
42Glutathione metabolism_Homo sapiens_hsa004800.79774311
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.77342241
44Sulfur metabolism_Homo sapiens_hsa009200.76966781
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.75289354
46Alzheimers disease_Homo sapiens_hsa050100.73776787
47Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72592353
48Oocyte meiosis_Homo sapiens_hsa041140.72508368
49Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71339155
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.68643327
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.66756174
52Herpes simplex infection_Homo sapiens_hsa051680.60888471
53Pentose phosphate pathway_Homo sapiens_hsa000300.59719300
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.59034211
55Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58062411
56Arachidonic acid metabolism_Homo sapiens_hsa005900.56865334
57Viral carcinogenesis_Homo sapiens_hsa052030.55705642
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.55514953
59N-Glycan biosynthesis_Homo sapiens_hsa005100.53246825
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.52191916
61Cyanoamino acid metabolism_Homo sapiens_hsa004600.49946231
62Antigen processing and presentation_Homo sapiens_hsa046120.49573590
63Metabolic pathways_Homo sapiens_hsa011000.47777401
64Biosynthesis of amino acids_Homo sapiens_hsa012300.45690203
65Regulation of autophagy_Homo sapiens_hsa041400.44507713
66Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43445567
67Sulfur relay system_Homo sapiens_hsa041220.40969115
68Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.40880486
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39046968
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.39005528
71HTLV-I infection_Homo sapiens_hsa051660.37913842
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36454674
73Primary immunodeficiency_Homo sapiens_hsa053400.33834130
74Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33769977
75Linoleic acid metabolism_Homo sapiens_hsa005910.33403523
76Peroxisome_Homo sapiens_hsa041460.31326552
77Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.31195023
78Allograft rejection_Homo sapiens_hsa053300.29468339
79Sphingolipid metabolism_Homo sapiens_hsa006000.29443900
80Arginine and proline metabolism_Homo sapiens_hsa003300.29156918
81Selenocompound metabolism_Homo sapiens_hsa004500.28030050
82NF-kappa B signaling pathway_Homo sapiens_hsa040640.27806409
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.25585880
84Legionellosis_Homo sapiens_hsa051340.25102984
85Fructose and mannose metabolism_Homo sapiens_hsa000510.24526981
86Asthma_Homo sapiens_hsa053100.21694700
87TGF-beta signaling pathway_Homo sapiens_hsa043500.21094679
88Alcoholism_Homo sapiens_hsa050340.21078475
89Autoimmune thyroid disease_Homo sapiens_hsa053200.21003264
90Graft-versus-host disease_Homo sapiens_hsa053320.19985146
91Galactose metabolism_Homo sapiens_hsa000520.19593572
92Ether lipid metabolism_Homo sapiens_hsa005650.19458455
93Phototransduction_Homo sapiens_hsa047440.19225313
94NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15600251
95Apoptosis_Homo sapiens_hsa042100.15155739
96Measles_Homo sapiens_hsa051620.14351499
97Caffeine metabolism_Homo sapiens_hsa002320.14243361
98Cardiac muscle contraction_Homo sapiens_hsa042600.14138952
99Steroid biosynthesis_Homo sapiens_hsa001000.13636515
100Tryptophan metabolism_Homo sapiens_hsa003800.13488519
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.13195040
102Shigellosis_Homo sapiens_hsa051310.12732846
103Fatty acid metabolism_Homo sapiens_hsa012120.12336758
104Carbon metabolism_Homo sapiens_hsa012000.11701909
105Hematopoietic cell lineage_Homo sapiens_hsa046400.11127063
106MicroRNAs in cancer_Homo sapiens_hsa052060.10745303
107alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.10320125
108Hippo signaling pathway_Homo sapiens_hsa043900.10056391
109Other glycan degradation_Homo sapiens_hsa005110.09689761
110Arginine biosynthesis_Homo sapiens_hsa002200.08441812
111Intestinal immune network for IgA production_Homo sapiens_hsa046720.08307618
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.07792168
113Transcriptional misregulation in cancer_Homo sapiens_hsa052020.07485523
114Butanoate metabolism_Homo sapiens_hsa006500.07471321
115Basal cell carcinoma_Homo sapiens_hsa052170.06270444
116Vitamin digestion and absorption_Homo sapiens_hsa049770.05770277
117Hedgehog signaling pathway_Homo sapiens_hsa043400.05410911
118Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.05381206
119Fatty acid degradation_Homo sapiens_hsa000710.05234414
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.05107498
121Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.04744007
122Thyroid cancer_Homo sapiens_hsa052160.04681266
123Small cell lung cancer_Homo sapiens_hsa052220.04219299
124Renin-angiotensin system_Homo sapiens_hsa046140.03476114
125Tyrosine metabolism_Homo sapiens_hsa003500.00655388
126Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.00436721
127Fat digestion and absorption_Homo sapiens_hsa049750.00204988

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