

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | proteasome assembly (GO:0043248) | 4.98979744 |
| 2 | DNA deamination (GO:0045006) | 4.85841532 |
| 3 | maturation of SSU-rRNA (GO:0030490) | 4.83325285 |
| 4 | ribosomal small subunit biogenesis (GO:0042274) | 4.60967964 |
| 5 | ribosomal small subunit assembly (GO:0000028) | 4.45244774 |
| 6 | ribosomal large subunit biogenesis (GO:0042273) | 4.42842201 |
| 7 | nucleobase biosynthetic process (GO:0046112) | 4.42711928 |
| 8 | ribonucleoprotein complex biogenesis (GO:0022613) | 4.42213954 |
| 9 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.41580456 |
| 10 | ribosome biogenesis (GO:0042254) | 4.41500661 |
| 11 | purine nucleobase biosynthetic process (GO:0009113) | 4.39657070 |
| 12 | transcription elongation from RNA polymerase III promoter (GO:0006385) | 4.39473742 |
| 13 | termination of RNA polymerase III transcription (GO:0006386) | 4.39473742 |
| 14 | DNA replication initiation (GO:0006270) | 4.38792337 |
| 15 | telomere maintenance via semi-conservative replication (GO:0032201) | 4.34223397 |
| 16 | rRNA modification (GO:0000154) | 4.31411482 |
| 17 | DNA replication checkpoint (GO:0000076) | 4.25631968 |
| 18 | DNA strand elongation (GO:0022616) | 4.20472322 |
| 19 | formation of translation preinitiation complex (GO:0001731) | 4.05712191 |
| 20 | mitotic metaphase plate congression (GO:0007080) | 4.02293122 |
| 21 | rRNA processing (GO:0006364) | 3.95944636 |
| 22 | spliceosomal snRNP assembly (GO:0000387) | 3.95306617 |
| 23 | 7-methylguanosine mRNA capping (GO:0006370) | 3.91179084 |
| 24 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.90494500 |
| 25 | viral transcription (GO:0019083) | 3.89013515 |
| 26 | telomere maintenance via recombination (GO:0000722) | 3.88414913 |
| 27 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.88306709 |
| 28 | translational termination (GO:0006415) | 3.87296854 |
| 29 | pseudouridine synthesis (GO:0001522) | 3.85943699 |
| 30 | 7-methylguanosine RNA capping (GO:0009452) | 3.85456638 |
| 31 | RNA capping (GO:0036260) | 3.85456638 |
| 32 | CENP-A containing nucleosome assembly (GO:0034080) | 3.83444739 |
| 33 | rRNA metabolic process (GO:0016072) | 3.82926228 |
| 34 | termination of RNA polymerase I transcription (GO:0006363) | 3.79377622 |
| 35 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.78510214 |
| 36 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.77511827 |
| 37 | transcription elongation from RNA polymerase I promoter (GO:0006362) | 3.75412487 |
| 38 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.75181867 |
| 39 | * ribosome assembly (GO:0042255) | 3.73796847 |
| 40 | transcription from RNA polymerase I promoter (GO:0006360) | 3.73412608 |
| 41 | transcription-coupled nucleotide-excision repair (GO:0006283) | 3.72274339 |
| 42 | chromatin remodeling at centromere (GO:0031055) | 3.71666793 |
| 43 | translational initiation (GO:0006413) | 3.60706777 |
| 44 | regulation of mitochondrial translation (GO:0070129) | 3.60610618 |
| 45 | chaperone-mediated protein transport (GO:0072321) | 3.60285269 |
| 46 | telomere maintenance via telomere lengthening (GO:0010833) | 3.59387604 |
| 47 | IMP metabolic process (GO:0046040) | 3.58812705 |
| 48 | negative regulation of ligase activity (GO:0051352) | 3.56989451 |
| 49 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.56989451 |
| 50 | regulation of nuclear cell cycle DNA replication (GO:0033262) | 3.56893130 |
| 51 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.55832008 |
| 52 | establishment of integrated proviral latency (GO:0075713) | 3.55658906 |
| 53 | mitotic recombination (GO:0006312) | 3.53095029 |
| 54 | establishment of viral latency (GO:0019043) | 3.51842830 |
| 55 | cellular component biogenesis (GO:0044085) | 3.49265510 |
| 56 | translational elongation (GO:0006414) | 3.48827024 |
| 57 | maturation of 5.8S rRNA (GO:0000460) | 3.47209627 |
| 58 | protein localization to kinetochore (GO:0034501) | 3.45501234 |
| 59 | spliceosomal complex assembly (GO:0000245) | 3.43069068 |
| 60 | IMP biosynthetic process (GO:0006188) | 3.39513562 |
| 61 | metaphase plate congression (GO:0051310) | 3.39075766 |
| 62 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.39056434 |
| 63 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.39056434 |
| 64 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.39056434 |
| 65 | rRNA methylation (GO:0031167) | 3.37778327 |
| 66 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.36226435 |
| 67 | DNA catabolic process, exonucleolytic (GO:0000738) | 3.35737358 |
| 68 | kinetochore assembly (GO:0051382) | 3.35136904 |
| 69 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.34628434 |
| 70 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.34628434 |
| 71 | translation (GO:0006412) | 3.33694606 |
| 72 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.33251213 |
| 73 | DNA replication-independent nucleosome organization (GO:0034724) | 3.33251213 |
| 74 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 3.32717498 |
| 75 | SRP-dependent cotranslational protein targeting to membrane (GO:0006614) | 3.32678226 |
| 76 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.32520681 |
| 77 | transcription initiation from RNA polymerase I promoter (GO:0006361) | 3.32153988 |
| 78 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.31890908 |
| 79 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.31387823 |
| 80 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.31387823 |
| 81 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.30627536 |
| 82 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.30226371 |
| 83 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 3.28999359 |
| 84 | ATP synthesis coupled proton transport (GO:0015986) | 3.28999359 |
| 85 | exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay | 3.28458478 |
| 86 | cotranslational protein targeting to membrane (GO:0006613) | 3.27575911 |
| 87 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.25509505 |
| 88 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.25509505 |
| 89 | protein targeting to ER (GO:0045047) | 3.24030583 |
| 90 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 3.23827788 |
| 91 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.23756402 |
| 92 | cell cycle G1/S phase transition (GO:0044843) | 3.23676578 |
| 93 | G1/S transition of mitotic cell cycle (GO:0000082) | 3.23676578 |
| 94 | mitochondrial RNA metabolic process (GO:0000959) | 3.23305659 |
| 95 | protein targeting to mitochondrion (GO:0006626) | 3.23303440 |
| 96 | DNA double-strand break processing (GO:0000729) | 3.22910576 |
| 97 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.22652914 |
| 98 | protein localization to chromosome, centromeric region (GO:0071459) | 3.21555942 |
| 99 | L-methionine biosynthetic process from methylthioadenosine (GO:0019509) | 3.21228327 |
| 100 | kinetochore organization (GO:0051383) | 3.20770954 |
| 101 | nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291) | 3.18509871 |
| 102 | positive regulation of ligase activity (GO:0051351) | 3.18431215 |
| 103 | deoxyribonucleotide biosynthetic process (GO:0009263) | 3.18165996 |
| 104 | mitotic sister chromatid segregation (GO:0000070) | 3.17492915 |
| 105 | regulation of double-strand break repair via homologous recombination (GO:0010569) | 3.16641655 |
| 106 | nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184) | 3.16246922 |
| 107 | histone exchange (GO:0043486) | 3.14288351 |
| 108 | regulation of ligase activity (GO:0051340) | 3.14152628 |
| 109 | DNA damage response, detection of DNA damage (GO:0042769) | 3.14068044 |
| 110 | transcription from mitochondrial promoter (GO:0006390) | 3.13227374 |
| 111 | mitotic nuclear envelope disassembly (GO:0007077) | 3.12020675 |
| 112 | ncRNA processing (GO:0034470) | 3.10811617 |
| 113 | nuclear pore complex assembly (GO:0051292) | 3.10592985 |
| 114 | viral mRNA export from host cell nucleus (GO:0046784) | 3.10165717 |
| 115 | cellular protein complex disassembly (GO:0043624) | 3.09618532 |
| 116 | protein localization to endoplasmic reticulum (GO:0070972) | 3.07714146 |
| 117 | histone mRNA metabolic process (GO:0008334) | 3.07290916 |
| 118 | ncRNA metabolic process (GO:0034660) | 3.06550411 |
| 119 | establishment of protein localization to endoplasmic reticulum (GO:0072599) | 3.06100401 |
| 120 | DNA-templated transcription, termination (GO:0006353) | 3.05706476 |
| 121 | cullin deneddylation (GO:0010388) | 3.05626826 |
| 122 | DNA unwinding involved in DNA replication (GO:0006268) | 3.03737585 |
| 123 | amino acid activation (GO:0043038) | 3.02598999 |
| 124 | tRNA aminoacylation (GO:0043039) | 3.02598999 |
| 125 | tRNA aminoacylation for protein translation (GO:0006418) | 3.02334231 |
| 126 | spindle checkpoint (GO:0031577) | 3.01787809 |
| 127 | pteridine-containing compound biosynthetic process (GO:0042559) | 3.01001494 |
| 128 | protein deneddylation (GO:0000338) | 2.99319467 |
| 129 | mitotic spindle checkpoint (GO:0071174) | 2.96828176 |
| 130 | DNA ligation (GO:0006266) | 2.96102756 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.80713136 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.69487472 |
| 3 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 4.22309525 |
| 4 | GABP_17652178_ChIP-ChIP_JURKAT_Human | 3.82766251 |
| 5 | EST1_17652178_ChIP-ChIP_JURKAT_Human | 3.74606700 |
| 6 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 3.62154600 |
| 7 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 3.48897819 |
| 8 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.39956740 |
| 9 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.32436950 |
| 10 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 3.32076861 |
| 11 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 3.24004750 |
| 12 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 3.14802528 |
| 13 | * MYC_18358816_ChIP-ChIP_MESCs_Mouse | 3.13629230 |
| 14 | * MYC_19030024_ChIP-ChIP_MESCs_Mouse | 3.12969900 |
| 15 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.82609216 |
| 16 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 2.75661196 |
| 17 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 2.73989405 |
| 18 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.70936827 |
| 19 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 2.62968693 |
| 20 | VDR_23849224_ChIP-Seq_CD4+_Human | 2.60803898 |
| 21 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 2.58530777 |
| 22 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 2.56846739 |
| 23 | * HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 2.51413689 |
| 24 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.46901223 |
| 25 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.45970339 |
| 26 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 2.28784595 |
| 27 | E2F1_18555785_ChIP-Seq_MESCs_Mouse | 2.27080187 |
| 28 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.21131952 |
| 29 | DCP1A_22483619_ChIP-Seq_HELA_Human | 2.15148277 |
| 30 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 2.12734703 |
| 31 | * FOXP3_21729870_ChIP-Seq_TREG_Human | 2.09471731 |
| 32 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 2.04546678 |
| 33 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 2.02614644 |
| 34 | ELK1_19687146_ChIP-ChIP_HELA_Human | 2.01965813 |
| 35 | * THAP11_20581084_ChIP-Seq_MESCs_Mouse | 2.01855344 |
| 36 | * TTF2_22483619_ChIP-Seq_HELA_Human | 2.00234692 |
| 37 | GABP_19822575_ChIP-Seq_HepG2_Human | 1.96740893 |
| 38 | * MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.89968596 |
| 39 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.86754175 |
| 40 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.83259675 |
| 41 | * ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.75829489 |
| 42 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.75496729 |
| 43 | * FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.74388204 |
| 44 | PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.73802623 |
| 45 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.70340347 |
| 46 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.61188958 |
| 47 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.58379527 |
| 48 | * MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.56709208 |
| 49 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.56170616 |
| 50 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.54380572 |
| 51 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.50463921 |
| 52 | HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.48205465 |
| 53 | PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 1.44654884 |
| 54 | NOTCH1_21737748_ChIP-Seq_TLL_Human | 1.41053275 |
| 55 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.37050333 |
| 56 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.35148204 |
| 57 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.33607896 |
| 58 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.33033013 |
| 59 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.32305656 |
| 60 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.32060553 |
| 61 | * ASH2L_23239880_ChIP-Seq_MESCs_Mouse | 1.29792355 |
| 62 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.28144222 |
| 63 | KDM5A_27292631_Chip-Seq_BREAST_Human | 1.28064583 |
| 64 | PADI4_21655091_ChIP-ChIP_MCF-7_Human | 1.26507259 |
| 65 | * ELK1_22589737_ChIP-Seq_MCF10A_Human | 1.26059322 |
| 66 | HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.25634626 |
| 67 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.25024546 |
| 68 | * FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.21710445 |
| 69 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 1.19451565 |
| 70 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.18864350 |
| 71 | KLF2_18264089_ChIP-ChIP_MESCs_Mouse | 1.18825139 |
| 72 | KLF5_18264089_ChIP-ChIP_MESCs_Mouse | 1.18825139 |
| 73 | KLF4_18264089_ChIP-ChIP_MESCs_Mouse | 1.18825139 |
| 74 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.16309590 |
| 75 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.13801121 |
| 76 | * SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.13237578 |
| 77 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.12329933 |
| 78 | MYC_18940864_ChIP-ChIP_HL60_Human | 1.12005278 |
| 79 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 1.11579158 |
| 80 | CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.04764624 |
| 81 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.03747565 |
| 82 | NANOG_18358816_ChIP-ChIP_MESCs_Mouse | 1.01553526 |
| 83 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.01145997 |
| 84 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 1.00665091 |
| 85 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 0.98291865 |
| 86 | * E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 0.97121408 |
| 87 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.96569935 |
| 88 | * KLF4_18555785_ChIP-Seq_MESCs_Mouse | 0.96478782 |
| 89 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 0.95253271 |
| 90 | TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.94645667 |
| 91 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 0.91771670 |
| 92 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 0.89692579 |
| 93 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 0.88335359 |
| 94 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.88289508 |
| 95 | SOX17_20123909_ChIP-Seq_XEN_Mouse | 0.88041658 |
| 96 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.87194598 |
| 97 | TFEB_21752829_ChIP-Seq_HELA_Human | 0.85793851 |
| 98 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 0.84197565 |
| 99 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.81925559 |
| 100 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 0.81209782 |
| 101 | OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.80738877 |
| 102 | ELF5_23300383_ChIP-Seq_T47D_Human | 0.80250529 |
| 103 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 0.80180916 |
| 104 | IRF1_19129219_ChIP-ChIP_H3396_Human | 0.78320672 |
| 105 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.78224260 |
| 106 | ZNF263_19887448_ChIP-Seq_K562_Human | 0.76822069 |
| 107 | * SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 0.76026415 |
| 108 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.75142710 |
| 109 | NANOG_16153702_ChIP-ChIP_HESCs_Human | 0.74774492 |
| 110 | CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 0.74536454 |
| 111 | CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human | 0.74300537 |
| 112 | * FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.73356154 |
| 113 | EWS_26573619_Chip-Seq_HEK293_Human | 0.69854380 |
| 114 | SOX2_16153702_ChIP-ChIP_HESCs_Human | 0.69415041 |
| 115 | CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 0.66588814 |
| 116 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.64639220 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.87028856 |
| 2 | MP0003111_abnormal_nucleus_morphology | 4.58498098 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 4.46282444 |
| 4 | MP0010094_abnormal_chromosome_stability | 4.43897279 |
| 5 | MP0008057_abnormal_DNA_replication | 4.20436646 |
| 6 | MP0003077_abnormal_cell_cycle | 3.99618150 |
| 7 | MP0008058_abnormal_DNA_repair | 3.98543031 |
| 8 | MP0008932_abnormal_embryonic_tissue | 3.04054868 |
| 9 | MP0003718_maternal_effect | 2.99685108 |
| 10 | MP0008007_abnormal_cellular_replicative | 2.94628646 |
| 11 | MP0003786_premature_aging | 2.63338135 |
| 12 | MP0009697_abnormal_copulation | 2.38591955 |
| 13 | MP0008877_abnormal_DNA_methylation | 2.36971381 |
| 14 | MP0006292_abnormal_olfactory_placode | 2.28379330 |
| 15 | MP0003123_paternal_imprinting | 2.25595109 |
| 16 | MP0001730_embryonic_growth_arrest | 2.05745144 |
| 17 | MP0009379_abnormal_foot_pigmentation | 1.97870119 |
| 18 | MP0002254_reproductive_system_inflammat | 1.94017087 |
| 19 | MP0000350_abnormal_cell_proliferation | 1.88509758 |
| 20 | MP0003806_abnormal_nucleotide_metabolis | 1.88337043 |
| 21 | MP0003315_abnormal_perineum_morphology | 1.82952025 |
| 22 | MP0003136_yellow_coat_color | 1.64446634 |
| 23 | MP0004133_heterotaxia | 1.55217301 |
| 24 | MP0002210_abnormal_sex_determination | 1.50015284 |
| 25 | MP0002160_abnormal_reproductive_system | 1.47186771 |
| 26 | MP0003941_abnormal_skin_development | 1.43684933 |
| 27 | MP0002396_abnormal_hematopoietic_system | 1.43051756 |
| 28 | MP0005380_embryogenesis_phenotype | 1.40017311 |
| 29 | MP0001672_abnormal_embryogenesis/_devel | 1.40017311 |
| 30 | MP0000313_abnormal_cell_death | 1.39634923 |
| 31 | MP0001697_abnormal_embryo_size | 1.39130324 |
| 32 | MP0003186_abnormal_redox_activity | 1.37183582 |
| 33 | MP0002080_prenatal_lethality | 1.31439180 |
| 34 | MP0001145_abnormal_male_reproductive | 1.31003811 |
| 35 | MP0009333_abnormal_splenocyte_physiolog | 1.30200143 |
| 36 | MP0005389_reproductive_system_phenotype | 1.29109947 |
| 37 | MP0002085_abnormal_embryonic_tissue | 1.27886645 |
| 38 | MP0000490_abnormal_crypts_of | 1.19746244 |
| 39 | MP0000372_irregular_coat_pigmentation | 1.19281907 |
| 40 | MP0002102_abnormal_ear_morphology | 1.18776945 |
| 41 | MP0000566_synostosis | 1.18388586 |
| 42 | MP0002132_abnormal_respiratory_system | 1.17768735 |
| 43 | MP0001188_hyperpigmentation | 1.16023951 |
| 44 | MP0002796_impaired_skin_barrier | 1.15135382 |
| 45 | MP0001929_abnormal_gametogenesis | 1.13142557 |
| 46 | MP0000653_abnormal_sex_gland | 1.12849005 |
| 47 | MP0003984_embryonic_growth_retardation | 1.12742359 |
| 48 | MP0002019_abnormal_tumor_incidence | 1.11872626 |
| 49 | MP0005501_abnormal_skin_physiology | 1.10736939 |
| 50 | MP0001293_anophthalmia | 1.09912879 |
| 51 | MP0002088_abnormal_embryonic_growth/wei | 1.08536229 |
| 52 | MP0008260_abnormal_autophagy | 1.05609478 |
| 53 | MP0001853_heart_inflammation | 1.05086965 |
| 54 | MP0003567_abnormal_fetal_cardiomyocyte | 1.03112055 |
| 55 | MP0003950_abnormal_plasma_membrane | 1.02595706 |
| 56 | MP0003121_genomic_imprinting | 1.02509672 |
| 57 | MP0002084_abnormal_developmental_patter | 0.99643444 |
| 58 | MP0009672_abnormal_birth_weight | 0.99224664 |
| 59 | MP0001919_abnormal_reproductive_system | 0.99126944 |
| 60 | MP0006035_abnormal_mitochondrial_morpho | 0.98333100 |
| 61 | MP0005408_hypopigmentation | 0.98120364 |
| 62 | MP0010352_gastrointestinal_tract_polyps | 0.97301596 |
| 63 | MP0010307_abnormal_tumor_latency | 0.96997174 |
| 64 | MP0001529_abnormal_vocalization | 0.96952247 |
| 65 | MP0006072_abnormal_retinal_apoptosis | 0.95337937 |
| 66 | MP0002277_abnormal_respiratory_mucosa | 0.94555363 |
| 67 | MP0003890_abnormal_embryonic-extraembry | 0.93637531 |
| 68 | MP0002938_white_spotting | 0.93567559 |
| 69 | MP0001873_stomach_inflammation | 0.93040171 |
| 70 | MP0001119_abnormal_female_reproductive | 0.92849712 |
| 71 | MP0010030_abnormal_orbit_morphology | 0.92216689 |
| 72 | MP0003937_abnormal_limbs/digits/tail_de | 0.92086243 |
| 73 | MP0001661_extended_life_span | 0.90155511 |
| 74 | MP0001986_abnormal_taste_sensitivity | 0.89575964 |
| 75 | MP0005395_other_phenotype | 0.89096346 |
| 76 | MP0001764_abnormal_homeostasis | 0.88702628 |
| 77 | MP0004197_abnormal_fetal_growth/weight/ | 0.86524795 |
| 78 | MP0000358_abnormal_cell_content/ | 0.86281078 |
| 79 | MP0002086_abnormal_extraembryonic_tissu | 0.86259818 |
| 80 | MP0002877_abnormal_melanocyte_morpholog | 0.86100942 |
| 81 | MP0003938_abnormal_ear_development | 0.85848712 |
| 82 | MP0002111_abnormal_tail_morphology | 0.82654053 |
| 83 | MP0008995_early_reproductive_senescence | 0.80727592 |
| 84 | MP0000703_abnormal_thymus_morphology | 0.80225966 |
| 85 | MP0003763_abnormal_thymus_physiology | 0.79599424 |
| 86 | MP0003119_abnormal_digestive_system | 0.79355941 |
| 87 | MP0001286_abnormal_eye_development | 0.79217448 |
| 88 | MP0001881_abnormal_mammary_gland | 0.76801303 |
| 89 | MP0005384_cellular_phenotype | 0.76702740 |
| 90 | MP0005075_abnormal_melanosome_morpholog | 0.76450977 |
| 91 | MP0006036_abnormal_mitochondrial_physio | 0.75033550 |
| 92 | MP0005084_abnormal_gallbladder_morpholo | 0.73969052 |
| 93 | MP0001542_abnormal_bone_strength | 0.72557961 |
| 94 | MP0005377_hearing/vestibular/ear_phenot | 0.72381088 |
| 95 | MP0003878_abnormal_ear_physiology | 0.72381088 |
| 96 | MP0000689_abnormal_spleen_morphology | 0.71813463 |
| 97 | MP0003936_abnormal_reproductive_system | 0.71805749 |
| 98 | MP0002722_abnormal_immune_system | 0.71383673 |
| 99 | MP0002751_abnormal_autonomic_nervous | 0.70492398 |
| 100 | MP0001727_abnormal_embryo_implantation | 0.70041024 |
| 101 | MP0000049_abnormal_middle_ear | 0.68442780 |
| 102 | MP0001216_abnormal_epidermal_layer | 0.67702053 |
| 103 | MP0008789_abnormal_olfactory_epithelium | 0.67616607 |
| 104 | MP0003698_abnormal_male_reproductive | 0.67270282 |
| 105 | MP0005409_darkened_coat_color | 0.66519365 |
| 106 | MP0000627_abnormal_mammary_gland | 0.66465465 |
| 107 | MP0002006_tumorigenesis | 0.66241382 |
| 108 | MP0005621_abnormal_cell_physiology | 0.66091176 |
| 109 | MP0000579_abnormal_nail_morphology | 0.65602463 |
| 110 | MP0004808_abnormal_hematopoietic_stem | 0.65349749 |
| 111 | MP0008873_increased_physiological_sensi | 0.63283771 |
| 112 | MP0002095_abnormal_skin_pigmentation | 0.61716871 |
| 113 | MP0000015_abnormal_ear_pigmentation | 0.61166921 |
| 114 | MP0008875_abnormal_xenobiotic_pharmacok | 0.60725781 |
| 115 | MP0002398_abnormal_bone_marrow | 0.60525557 |
| 116 | MP0000647_abnormal_sebaceous_gland | 0.60256359 |
| 117 | MP0001485_abnormal_pinna_reflex | 0.60216510 |
| 118 | MP0001905_abnormal_dopamine_level | 0.59869309 |
| 119 | MP0002163_abnormal_gland_morphology | 0.59745867 |
| 120 | MP0005451_abnormal_body_composition | 0.59356423 |
| 121 | MP0003699_abnormal_female_reproductive | 0.58878572 |
| 122 | MP0010234_abnormal_vibrissa_follicle | 0.57941014 |
| 123 | MP0005266_abnormal_metabolism | 0.57567713 |
| 124 | MP0004381_abnormal_hair_follicle | 0.57286108 |
| 125 | MP0000858_altered_metastatic_potential | 0.56874319 |
| 126 | MP0002060_abnormal_skin_morphology | 0.56698831 |
| 127 | MP0000762_abnormal_tongue_morphology | 0.51009857 |
| 128 | MP0005410_abnormal_fertilization | 0.50432932 |
| 129 | MP0001186_pigmentation_phenotype | 0.50423611 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Birth length less than 3rd percentile (HP:0003561) | 5.82227195 |
| 2 | Breast hypoplasia (HP:0003187) | 5.02385403 |
| 3 | Cerebral hypomyelination (HP:0006808) | 4.26529166 |
| 4 | Reticulocytopenia (HP:0001896) | 4.23815139 |
| 5 | Abnormality of cells of the erythroid lineage (HP:0012130) | 3.95415362 |
| 6 | Abnormal number of erythroid precursors (HP:0012131) | 3.76316927 |
| 7 | Carpal bone hypoplasia (HP:0001498) | 3.74125679 |
| 8 | Rough bone trabeculation (HP:0100670) | 3.64758658 |
| 9 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 3.58158416 |
| 10 | Acute encephalopathy (HP:0006846) | 3.52878212 |
| 11 | Oral leukoplakia (HP:0002745) | 3.52229467 |
| 12 | Chromsome breakage (HP:0040012) | 3.46913402 |
| 13 | Macrocytic anemia (HP:0001972) | 3.27729674 |
| 14 | Patellar aplasia (HP:0006443) | 3.20238667 |
| 15 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 3.15816208 |
| 16 | Abnormality of methionine metabolism (HP:0010901) | 3.12602531 |
| 17 | Meckel diverticulum (HP:0002245) | 3.10852259 |
| 18 | Absent radius (HP:0003974) | 3.09133554 |
| 19 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.07263985 |
| 20 | Abnormality of the preputium (HP:0100587) | 3.05025026 |
| 21 | Duplicated collecting system (HP:0000081) | 2.94333465 |
| 22 | Aplasia involving forearm bones (HP:0009822) | 2.93068931 |
| 23 | Absent forearm bone (HP:0003953) | 2.93068931 |
| 24 | Progressive macrocephaly (HP:0004481) | 2.93006062 |
| 25 | Abnormality of the ileum (HP:0001549) | 2.92060426 |
| 26 | Abnormal trabecular bone morphology (HP:0100671) | 2.87607598 |
| 27 | Multiple enchondromatosis (HP:0005701) | 2.81536756 |
| 28 | Absent thumb (HP:0009777) | 2.80734532 |
| 29 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.75320783 |
| 30 | Aplastic anemia (HP:0001915) | 2.74284767 |
| 31 | Progressive external ophthalmoplegia (HP:0000590) | 2.73653427 |
| 32 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.73000996 |
| 33 | 3-Methylglutaconic aciduria (HP:0003535) | 2.71986009 |
| 34 | Abnormality of chromosome stability (HP:0003220) | 2.71417456 |
| 35 | Premature graying of hair (HP:0002216) | 2.71271336 |
| 36 | Supernumerary spleens (HP:0009799) | 2.69528346 |
| 37 | Reduced antithrombin III activity (HP:0001976) | 2.69494981 |
| 38 | Pallor (HP:0000980) | 2.68447087 |
| 39 | Horseshoe kidney (HP:0000085) | 2.61986339 |
| 40 | Lactic acidosis (HP:0003128) | 2.61872283 |
| 41 | Cerebral edema (HP:0002181) | 2.61279811 |
| 42 | Hepatic necrosis (HP:0002605) | 2.60695375 |
| 43 | Abnormality of the renal collecting system (HP:0004742) | 2.59887820 |
| 44 | Abnormality of the anterior horn cell (HP:0006802) | 2.59845815 |
| 45 | Degeneration of anterior horn cells (HP:0002398) | 2.59845815 |
| 46 | Bone marrow hypocellularity (HP:0005528) | 2.57961517 |
| 47 | CNS hypomyelination (HP:0003429) | 2.54588777 |
| 48 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.53507122 |
| 49 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 2.51524296 |
| 50 | Increased serum lactate (HP:0002151) | 2.51268813 |
| 51 | Methylmalonic acidemia (HP:0002912) | 2.47398979 |
| 52 | Amniotic constriction ring (HP:0009775) | 2.47006114 |
| 53 | Abnormality of placental membranes (HP:0011409) | 2.47006114 |
| 54 | Colon cancer (HP:0003003) | 2.46970838 |
| 55 | Secondary amenorrhea (HP:0000869) | 2.44103868 |
| 56 | Renal Fanconi syndrome (HP:0001994) | 2.42152432 |
| 57 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.41664333 |
| 58 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.41664333 |
| 59 | Abnormal protein glycosylation (HP:0012346) | 2.41664333 |
| 60 | Abnormal glycosylation (HP:0012345) | 2.41664333 |
| 61 | Selective tooth agenesis (HP:0001592) | 2.40728340 |
| 62 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.38957458 |
| 63 | Abnormality of serum amino acid levels (HP:0003112) | 2.38827983 |
| 64 | Microretrognathia (HP:0000308) | 2.38135679 |
| 65 | Impulsivity (HP:0100710) | 2.38082063 |
| 66 | Triphalangeal thumb (HP:0001199) | 2.36649462 |
| 67 | Type 2 muscle fiber atrophy (HP:0003554) | 2.36042205 |
| 68 | Increased hepatocellular lipid droplets (HP:0006565) | 2.35983215 |
| 69 | Abnormality of the labia minora (HP:0012880) | 2.35630206 |
| 70 | Microvesicular hepatic steatosis (HP:0001414) | 2.35408882 |
| 71 | Premature ovarian failure (HP:0008209) | 2.35277657 |
| 72 | Acute necrotizing encephalopathy (HP:0006965) | 2.34460074 |
| 73 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 2.33023745 |
| 74 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 2.33023745 |
| 75 | Irregular epiphyses (HP:0010582) | 2.30867809 |
| 76 | Trismus (HP:0000211) | 2.28730888 |
| 77 | Aplasia/Hypoplasia involving the musculature (HP:0001460) | 2.27702295 |
| 78 | Type I transferrin isoform profile (HP:0003642) | 2.24463537 |
| 79 | Squamous cell carcinoma (HP:0002860) | 2.24233600 |
| 80 | Mitochondrial inheritance (HP:0001427) | 2.23978724 |
| 81 | Hypoplasia of the pons (HP:0012110) | 2.23909273 |
| 82 | Neoplasm of the pancreas (HP:0002894) | 2.23403046 |
| 83 | Abnormality of the pons (HP:0007361) | 2.22464260 |
| 84 | Muscle fiber atrophy (HP:0100295) | 2.20351407 |
| 85 | Cleft eyelid (HP:0000625) | 2.18594104 |
| 86 | Abnormality of glycolysis (HP:0004366) | 2.18090210 |
| 87 | Increased serum pyruvate (HP:0003542) | 2.18090210 |
| 88 | Methylmalonic aciduria (HP:0012120) | 2.17985614 |
| 89 | Abnormality of the duodenum (HP:0002246) | 2.17661990 |
| 90 | Cellular immunodeficiency (HP:0005374) | 2.17446067 |
| 91 | Increased CSF lactate (HP:0002490) | 2.17330182 |
| 92 | Homocystinuria (HP:0002156) | 2.16811314 |
| 93 | Abnormality of homocysteine metabolism (HP:0010919) | 2.16811314 |
| 94 | Respiratory difficulties (HP:0002880) | 2.16343868 |
| 95 | Duodenal stenosis (HP:0100867) | 2.15520537 |
| 96 | Small intestinal stenosis (HP:0012848) | 2.15520537 |
| 97 | Pancytopenia (HP:0001876) | 2.12925000 |
| 98 | Progressive muscle weakness (HP:0003323) | 2.12715672 |
| 99 | Agnosia (HP:0010524) | 2.12707154 |
| 100 | Sparse eyelashes (HP:0000653) | 2.12529396 |
| 101 | Medulloblastoma (HP:0002885) | 2.12073181 |
| 102 | Myelodysplasia (HP:0002863) | 2.06668202 |
| 103 | Respiratory failure (HP:0002878) | 2.03926033 |
| 104 | Abnormality of the carotid arteries (HP:0005344) | 2.03612413 |
| 105 | Congenital nonbullous ichthyosiform erythroderma (HP:0007479) | 2.03450799 |
| 106 | Ureteral duplication (HP:0000073) | 2.02998414 |
| 107 | Aplasia/Hypoplasia of the earlobes (HP:0009906) | 2.02481024 |
| 108 | Abnormality of alanine metabolism (HP:0010916) | 2.00494739 |
| 109 | Hyperalaninemia (HP:0003348) | 2.00494739 |
| 110 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.00494739 |
| 111 | Abnormal lung lobation (HP:0002101) | 2.00338093 |
| 112 | Hepatocellular necrosis (HP:0001404) | 1.99576365 |
| 113 | Hypoplasia of the radius (HP:0002984) | 1.99179287 |
| 114 | Aplasia/hypoplasia of the uterus (HP:0008684) | 1.98102847 |
| 115 | Tracheoesophageal fistula (HP:0002575) | 1.97099464 |
| 116 | Clubbing of toes (HP:0100760) | 1.95984200 |
| 117 | 11 pairs of ribs (HP:0000878) | 1.95964071 |
| 118 | Nephroblastoma (Wilms tumor) (HP:0002667) | 1.95526795 |
| 119 | Abnormal mitochondria in muscle tissue (HP:0008316) | 1.95509889 |
| 120 | Lethargy (HP:0001254) | 1.95268589 |
| 121 | Stenosis of the external auditory canal (HP:0000402) | 1.95143486 |
| 122 | Breast aplasia (HP:0100783) | 1.95056211 |
| 123 | Leukodystrophy (HP:0002415) | 1.94395003 |
| 124 | Megaloblastic anemia (HP:0001889) | 1.91305976 |
| 125 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 1.90441462 |
| 126 | Increased intramyocellular lipid droplets (HP:0012240) | 1.89439073 |
| 127 | Exercise intolerance (HP:0003546) | 1.89323881 |
| 128 | Exertional dyspnea (HP:0002875) | 1.89211373 |
| 129 | Sloping forehead (HP:0000340) | 1.89194764 |
| 130 | Asplenia (HP:0001746) | 1.88782091 |
| 131 | Aplasia/Hypoplasia of the breasts (HP:0010311) | 1.87604489 |
| 132 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 1.87602000 |
| 133 | Sensory axonal neuropathy (HP:0003390) | 1.86518485 |
| 134 | Abnormalities of placenta or umbilical cord (HP:0001194) | 1.86184366 |
| 135 | Lipid accumulation in hepatocytes (HP:0006561) | 1.85839164 |
| 136 | Glossoptosis (HP:0000162) | 1.85450206 |
| 137 | Embryonal renal neoplasm (HP:0011794) | 1.82668495 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 5.32866578 |
| 2 | WEE1 | 4.09674231 |
| 3 | PLK4 | 3.93191563 |
| 4 | STK16 | 3.65734880 |
| 5 | VRK2 | 3.49519690 |
| 6 | EIF2AK1 | 3.45488281 |
| 7 | SRPK1 | 2.94390454 |
| 8 | IRAK3 | 2.88858633 |
| 9 | CDC7 | 2.64201079 |
| 10 | ZAK | 2.63736921 |
| 11 | TSSK6 | 2.47060948 |
| 12 | EIF2AK3 | 2.34733310 |
| 13 | VRK1 | 2.23023810 |
| 14 | TTK | 2.19120383 |
| 15 | TESK2 | 2.06262338 |
| 16 | NME2 | 2.01576730 |
| 17 | EPHA2 | 1.95349953 |
| 18 | MKNK1 | 1.80603798 |
| 19 | PLK3 | 1.76399248 |
| 20 | PLK1 | 1.76001150 |
| 21 | TRIM28 | 1.73545130 |
| 22 | BRSK2 | 1.69142627 |
| 23 | TLK1 | 1.64460717 |
| 24 | PNCK | 1.61727330 |
| 25 | TAF1 | 1.60913477 |
| 26 | MKNK2 | 1.58992710 |
| 27 | ACVR1B | 1.58721091 |
| 28 | DYRK3 | 1.50263715 |
| 29 | NUAK1 | 1.46928453 |
| 30 | IRAK4 | 1.44829211 |
| 31 | MARK1 | 1.38451680 |
| 32 | NME1 | 1.38223829 |
| 33 | PBK | 1.38176203 |
| 34 | NEK2 | 1.31673361 |
| 35 | ATR | 1.29714524 |
| 36 | RPS6KB2 | 1.25107131 |
| 37 | CDK7 | 1.22920163 |
| 38 | AURKB | 1.21289215 |
| 39 | CHEK2 | 1.17256013 |
| 40 | AURKA | 1.16819273 |
| 41 | EIF2AK2 | 1.13416883 |
| 42 | DYRK2 | 1.05126320 |
| 43 | NEK1 | 1.02956315 |
| 44 | MST4 | 0.98200674 |
| 45 | SCYL2 | 0.93962875 |
| 46 | IRAK2 | 0.93708147 |
| 47 | BRSK1 | 0.93307630 |
| 48 | PIM2 | 0.93219232 |
| 49 | WNK3 | 0.92148887 |
| 50 | STK38L | 0.91686269 |
| 51 | KDR | 0.90058216 |
| 52 | PRKCI | 0.89450221 |
| 53 | CHEK1 | 0.87016697 |
| 54 | PASK | 0.85869586 |
| 55 | ERBB4 | 0.84332754 |
| 56 | MAP3K8 | 0.84034574 |
| 57 | PAK4 | 0.83197337 |
| 58 | AKT3 | 0.81839163 |
| 59 | BRAF | 0.80079376 |
| 60 | MAP3K12 | 0.78438046 |
| 61 | STK4 | 0.71742499 |
| 62 | IRAK1 | 0.71620389 |
| 63 | CSNK2A2 | 0.70504597 |
| 64 | SMG1 | 0.70115193 |
| 65 | RPS6KA4 | 0.70040092 |
| 66 | CSNK2A1 | 0.68919900 |
| 67 | RPS6KA5 | 0.68082354 |
| 68 | CCNB1 | 0.67798988 |
| 69 | NEK6 | 0.64425323 |
| 70 | STK3 | 0.64385848 |
| 71 | PAK1 | 0.61773061 |
| 72 | ATM | 0.59156689 |
| 73 | TNIK | 0.58394830 |
| 74 | MST1R | 0.57936233 |
| 75 | CDK2 | 0.55246748 |
| 76 | TESK1 | 0.53343235 |
| 77 | ABL2 | 0.52785696 |
| 78 | PIM1 | 0.52765260 |
| 79 | CDK9 | 0.51870477 |
| 80 | TGFBR1 | 0.50192115 |
| 81 | BRD4 | 0.48770352 |
| 82 | CDK8 | 0.47275888 |
| 83 | STK10 | 0.44973177 |
| 84 | CDK1 | 0.44519943 |
| 85 | LIMK1 | 0.43802876 |
| 86 | LATS2 | 0.42815129 |
| 87 | CDK4 | 0.41267682 |
| 88 | DAPK1 | 0.40460464 |
| 89 | CSNK1G3 | 0.40001721 |
| 90 | MUSK | 0.38223161 |
| 91 | MAP3K11 | 0.38199208 |
| 92 | MAP4K2 | 0.38061090 |
| 93 | CSNK1E | 0.37586248 |
| 94 | FGFR1 | 0.34801823 |
| 95 | CLK1 | 0.34400868 |
| 96 | BMPR1B | 0.33123338 |
| 97 | ARAF | 0.32946696 |
| 98 | IKBKB | 0.32480740 |
| 99 | ADRBK2 | 0.30453557 |
| 100 | BCR | 0.29668409 |
| 101 | MAP3K14 | 0.28841356 |
| 102 | ALK | 0.28266803 |
| 103 | ERBB3 | 0.26202369 |
| 104 | MELK | 0.25783821 |
| 105 | CDK3 | 0.24780730 |
| 106 | BLK | 0.24487340 |
| 107 | CSNK1G1 | 0.23187720 |
| 108 | PDK2 | 0.23087815 |
| 109 | MAPKAPK3 | 0.22380530 |
| 110 | TXK | 0.21897510 |
| 111 | YES1 | 0.21725271 |
| 112 | BCKDK | 0.21681730 |
| 113 | CDK6 | 0.21103247 |
| 114 | OXSR1 | 0.20139145 |
| 115 | AKT2 | 0.19925432 |
| 116 | TAOK2 | 0.19696835 |
| 117 | PRKDC | 0.19657111 |
| 118 | CSNK1A1L | 0.18876744 |
| 119 | STK24 | 0.16980213 |
| 120 | MARK3 | 0.15511905 |
| 121 | PLK2 | 0.15175288 |
| 122 | CDK19 | 0.14407843 |
| 123 | CAMK2B | 0.13136102 |
| 124 | LYN | 0.12979576 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | RNA polymerase_Homo sapiens_hsa03020 | 4.44457393 |
| 2 | Proteasome_Homo sapiens_hsa03050 | 4.40539623 |
| 3 | DNA replication_Homo sapiens_hsa03030 | 4.38721045 |
| 4 | Ribosome_Homo sapiens_hsa03010 | 4.12749093 |
| 5 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.96984661 |
| 6 | Mismatch repair_Homo sapiens_hsa03430 | 3.87608524 |
| 7 | Spliceosome_Homo sapiens_hsa03040 | 3.21878226 |
| 8 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.89881449 |
| 9 | RNA transport_Homo sapiens_hsa03013 | 2.89527200 |
| 10 | Homologous recombination_Homo sapiens_hsa03440 | 2.84403612 |
| 11 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.81374005 |
| 12 | Base excision repair_Homo sapiens_hsa03410 | 2.48409383 |
| 13 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 2.42432837 |
| 14 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.30226064 |
| 15 | Basal transcription factors_Homo sapiens_hsa03022 | 2.22269361 |
| 16 | Cell cycle_Homo sapiens_hsa04110 | 2.16903276 |
| 17 | One carbon pool by folate_Homo sapiens_hsa00670 | 2.12988212 |
| 18 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.88877020 |
| 19 | RNA degradation_Homo sapiens_hsa03018 | 1.84340058 |
| 20 | Purine metabolism_Homo sapiens_hsa00230 | 1.69602002 |
| 21 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.64918385 |
| 22 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 1.62694992 |
| 23 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.54079537 |
| 24 | Parkinsons disease_Homo sapiens_hsa05012 | 1.41314719 |
| 25 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.39126678 |
| 26 | Huntingtons disease_Homo sapiens_hsa05016 | 1.37926607 |
| 27 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.33533606 |
| 28 | Protein export_Homo sapiens_hsa03060 | 1.32410752 |
| 29 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 1.29390149 |
| 30 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.28069357 |
| 31 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.27274638 |
| 32 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.26589403 |
| 33 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.21671313 |
| 34 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.04977309 |
| 35 | Propanoate metabolism_Homo sapiens_hsa00640 | 1.02257842 |
| 36 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.97650354 |
| 37 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.93308456 |
| 38 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.93193966 |
| 39 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.89878218 |
| 40 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.83479628 |
| 41 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.81496604 |
| 42 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.79774311 |
| 43 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.77342241 |
| 44 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.76966781 |
| 45 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.75289354 |
| 46 | Alzheimers disease_Homo sapiens_hsa05010 | 0.73776787 |
| 47 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 0.72592353 |
| 48 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.72508368 |
| 49 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.71339155 |
| 50 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.68643327 |
| 51 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.66756174 |
| 52 | Herpes simplex infection_Homo sapiens_hsa05168 | 0.60888471 |
| 53 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.59719300 |
| 54 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.59034211 |
| 55 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.58062411 |
| 56 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.56865334 |
| 57 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.55705642 |
| 58 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.55514953 |
| 59 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.53246825 |
| 60 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 0.52191916 |
| 61 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.49946231 |
| 62 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.49573590 |
| 63 | Metabolic pathways_Homo sapiens_hsa01100 | 0.47777401 |
| 64 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 0.45690203 |
| 65 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.44507713 |
| 66 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.43445567 |
| 67 | Sulfur relay system_Homo sapiens_hsa04122 | 0.40969115 |
| 68 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.40880486 |
| 69 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 0.39046968 |
| 70 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.39005528 |
| 71 | HTLV-I infection_Homo sapiens_hsa05166 | 0.37913842 |
| 72 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.36454674 |
| 73 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.33834130 |
| 74 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.33769977 |
| 75 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.33403523 |
| 76 | Peroxisome_Homo sapiens_hsa04146 | 0.31326552 |
| 77 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.31195023 |
| 78 | Allograft rejection_Homo sapiens_hsa05330 | 0.29468339 |
| 79 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.29443900 |
| 80 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.29156918 |
| 81 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.28030050 |
| 82 | NF-kappa B signaling pathway_Homo sapiens_hsa04064 | 0.27806409 |
| 83 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.25585880 |
| 84 | Legionellosis_Homo sapiens_hsa05134 | 0.25102984 |
| 85 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.24526981 |
| 86 | Asthma_Homo sapiens_hsa05310 | 0.21694700 |
| 87 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.21094679 |
| 88 | Alcoholism_Homo sapiens_hsa05034 | 0.21078475 |
| 89 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.21003264 |
| 90 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.19985146 |
| 91 | Galactose metabolism_Homo sapiens_hsa00052 | 0.19593572 |
| 92 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.19458455 |
| 93 | Phototransduction_Homo sapiens_hsa04744 | 0.19225313 |
| 94 | NOD-like receptor signaling pathway_Homo sapiens_hsa04621 | 0.15600251 |
| 95 | Apoptosis_Homo sapiens_hsa04210 | 0.15155739 |
| 96 | Measles_Homo sapiens_hsa05162 | 0.14351499 |
| 97 | Caffeine metabolism_Homo sapiens_hsa00232 | 0.14243361 |
| 98 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.14138952 |
| 99 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.13636515 |
| 100 | Tryptophan metabolism_Homo sapiens_hsa00380 | 0.13488519 |
| 101 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.13195040 |
| 102 | Shigellosis_Homo sapiens_hsa05131 | 0.12732846 |
| 103 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.12336758 |
| 104 | Carbon metabolism_Homo sapiens_hsa01200 | 0.11701909 |
| 105 | Hematopoietic cell lineage_Homo sapiens_hsa04640 | 0.11127063 |
| 106 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.10745303 |
| 107 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.10320125 |
| 108 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.10056391 |
| 109 | Other glycan degradation_Homo sapiens_hsa00511 | 0.09689761 |
| 110 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.08441812 |
| 111 | Intestinal immune network for IgA production_Homo sapiens_hsa04672 | 0.08307618 |
| 112 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.07792168 |
| 113 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.07485523 |
| 114 | Butanoate metabolism_Homo sapiens_hsa00650 | 0.07471321 |
| 115 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.06270444 |
| 116 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.05770277 |
| 117 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.05410911 |
| 118 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.05381206 |
| 119 | Fatty acid degradation_Homo sapiens_hsa00071 | 0.05234414 |
| 120 | RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622 | 0.05107498 |
| 121 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 0.04744007 |
| 122 | Thyroid cancer_Homo sapiens_hsa05216 | 0.04681266 |
| 123 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.04219299 |
| 124 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.03476114 |
| 125 | Tyrosine metabolism_Homo sapiens_hsa00350 | 0.00655388 |
| 126 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.00436721 |
| 127 | Fat digestion and absorption_Homo sapiens_hsa04975 | 0.00204988 |

